Document bB2z3odqxKJ88zaV1zEqzreBD

Industrial HvRlcne Digest Aufluh ;y CHEMICAL HAZARDS 740 Plastics, The Toxicology of Synthetic Resins. R. H. Wilson and W. E. MeCormic}, Pr*h. Ind, Health lt 536*546 (June i960). \. THU presentation ! tho Third revision of a paper originally written in '.ml, Med, h Surg. 23. 479 (1934)). It represents a compilation of the Utorature ... Corning the toxicological properties of eynthetic ratine. While not all-inclusive, th<- i.. Uography can be used at a reference for the investigator of the toxicology of plastics, second revision was presented in November, 1953 (Ind. Med. It Surg. 34 , 491 The authors discuss the subject under the following headings: acrylic resins, alkyd r-. amino (urea and melamine) resins, cellulose plastic materials, coumarone-indene r:.* epoxies, fluorocarbons, nylon, phenolic resins, polyethylene, polyester rosins, sl'i-r*. polystyrene, vinyl resins, and polyurethanes. There are 114 references to the the bibliography. f f t 751 Toxicity of Piboranc In High Concentrations. A. R* Stumpe. _____ A.M.A. Arch. Ind. Health 2J_. $19-524 (June I960). Toxic signs and pathological evidence of severe pulmonary damage were ob*cr... In golden hamsters after Inhalation of relatively high concentrations of dlborane. As the eentration of diborane was increased from 50 ppm (58 mg. per cu. m.) to 600 ppm (ti>t, n A per cu. m.), the mean survival time for exposed hamsters decreased. Also noted n progressiva narrowing of the time interval for all exposed animals to die. However, cur., S4 * V A centrations in excess of 600 ppm (696 mg. per cu. m.) elicited no further reduction in il.~ minimum, maximum, or mean exposure times for death, Additional toxicopsthologkal studies are necessary for a complete understanding of the mechanism of action of dibwik:>, In view of diborane's extrome toxicity it becomes imperative that future aircraft and roc#: utilising the boranes as high-energy fuel* be designed to provide tho utmost protection' kg't* i accidental cabin air contamination. *, -- Author's sunmi-m R h e. r 752 The Toxicology of Do ran Hydrides. C. J. Levinekas, CWL-TM-27-7. Chemical 1 Warefare Labs,, Army Chemical Center, Md. 28 pp. (Dec. 1956). i A subacute and chronic inhalation study wae conducted with pentaborane, Th. : > mer, at 1.0 ppm, resulted in the death of several animals within 4 weeks <20 exposure*). i The chronic study was conducted at 0.2 ppm of pentaborane for approximately 6 nmnvb*. During this period, the animals showed a loss of appetite, weight !os, apathy, Uocllif/, creased physical activity, and muscle tromore. Less frequently observed wore an to pain, impaired mobility of the limbs, and signs uf eye and nasal irritation. The rats showed un elevated homatndrlt. The txposed dogs showed signs of liver damage I ured by the hromoulfaleln test. While no marked impairment of excretory ability w* !*. the exposed dogs frequently showed blood levels of the dye in excess of 10^' and 5ft for - 45 minutes respectively. All of the other toots gave values within normal limits, U is that, where the possibility of prolonged and repeated exposure to this chemical cx'.hti. . quote ventilation be provided to keep the concentration of pentaboranu below 0.2 ppm. - Nuclear Sci, AWm*. T$5 T O tb A. bi Wt lo in w A: iI ch cb i cl3, i 3>> ,j 12 i .?