Document bB1O7RbOqB15onGNv26g3ZeR3

AR226 _ 3465 w" 125231One-GeoerationReprodotionSy nats ~ Dens AR226 _ 3265 `TRADE SECRET Study Title H-25231: One-Generation Reproduction Study in Rats Volume 3 of 3 Laboratory Project ID: DuPont-9763 - AUTHOR: Eve Mylchreest, Ph.D. STUDY COMPLETED ON: January 31, 2003 PERFORMING LABORATORY: EL du Pont de Nemours and Company `Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 `Newark, Delaware 19714-0050 WORK REQUEST Nome} Seavice Cone ovens (Uy | ~~ | || | r-------- FTaTg-- s Co-- -- mpany--Sa-- ni-- zsd. D-- o-- ss ot-- con-- tain TSCA CBI H-25231: OneGeneration Reproduction Study in Rats --~ DuPont.9763 APPENDIX FF INDIVIDUAL ANIMAL PATHOLOGY DATA - P; ADULTS ~~ -- 7 - Company Sanitized. Does not containTSCA CBI 25231: OneGeneration Reproduction Study in Rats Dupont9763 ~ INDIVIDUAL ANIMAL PATHOLOGY DATA ~ Py ADULTS EXPLANATORY NOTES Note Microscopic Observations For male rats, the study database reports testes and epididymides (plural); however, only one testis and one epididymidis per rat was available for examination. --~ --~ 5 -- Company Sr~t"ad. Does not contain TSCACBI B~ 2 1:Ei i2 ii Fo ii 3 i i8 i Bai : iEK:iE : ] d bil ii i i i B | l | : i4 | Hi ia ighl i i Bi i : | i '] , :3 i I Ei iii i lip uf l i ig | i li B h Hd i i45 g l | g : i a iIi= ioi rid iellinljii fe 1 iTF al fh iE - | i4 : i HE 3 .i ; eq 13 c:io:i i gi | ig i1d Fl k g hiHE , EER LHgy Fbpalnd hi2B HE : i i pin 3 8 fled Li TH i gpg id : FL Bini | pod I ~ g i i : Pi i i pd : 1 io. i i Eg dl hi o5 l ouf d i hog dri ; 3 dosig B3;r8 B arraiad i: d rGiiflf 3i Mish Pyof t dfilleoaul : Thy HH : : z ep~ d2 inE } sq,EHTS ;8 RH i gs iff ss I~ & PF are b4 } ii i ;1 pod i] dey bb sPyd ippiodd i Hl ph! ie 22 dl J BE itil i Iii: Lidl Bin HERE] Po RH : iy Pid se i1 ACEI Hi = i !i i i i ,: i : oR! : ~ Py id] ig i j! ; ; Bod i :1 ] i; ! ifo : iiHIE i aHiH g itPid! Lc HH fIaig: B8E3TRE Boi iit Bgiie:rl00 ii Wilh : : Lyg B1188 12]1 2i BBoa p gi iiln 4 : ll iiihih 3 PEE reed 3 ERE i8 hr i i i |i|pli ii iPofd Hi T i3 Eoin if:rp if: Hl CRREIEEY Hoggd 5 g IE jill Pon 3 fi fig; 1 8 s EE i Lal I iBiyiite 8 S rp BL RE i poi Foil IolRH Po hit NEE ibtog pflsedb Hi: grid gas Hild Ii vy: dpiapni : IRIN {id bh ii ii i 2 : TE i Ha i , :| i1o . Pp | opiin } iHyl L gial | oy d| if1: h ifit t :i IE EAH i B80l5: | i ir Bi g 8 iITEy i] ppg i i i5 3 G0 hi ie fil 5 sio:f CliREO iptF EEiEgE i1"43s Big EE I brani ] s Bg pied 2z dpi 8 Bgp3ipip I~ gl 3 2 ] ii { pi: onPPdo|g | iiolioe iHI giyid! ;! Pos ty Liilglh i ; fas g Galle 8boi Pe fy gil din i id Hin | 81 3iy Hib Hild ; ~ ; i {i i po i 1 qd | :[I { ijit ii gz g by il 3g:io hl SEE ' JbA EER 51 ifi:. gldali q Hi poi [BhEhE yoo sghn diy | I pr ELE ~ fl :i i iy i po jiu 3] g Pl hwooih| i 1s Poi pBiitl Hil LHI ir, ii: P] aiPlo j i: 2 iis HE EEE g | 8 z 5 Pou ood g3 To i Pon i i 58 8 Pi oipg fF Ii TEI ia (ad 5 Ll igqt i lli {it 1s $88 58 dgoid,: n ifphal 4 ii ii i pg tiin dl . 1 CH 1ivggBE da BnErn Ed0Rb. |. i 2 ib ! i bi i F2I I 58 j3 i 3ob ia1gl1y8 iH ob nil gloat if, if s 3H3. 3 I i 5 g 5 ii fEah i 1 ciH rErilee ~ 1 8 Po i i tf Pon 1 i ipo a i i8 ig il I ior8 ai ly bg pil = 2 iy a2 LE ER ib in : ii ! 1I i"5g: HsoL ff iiigas 8 I ir iiipip Pooq]) :3 pf i C1& H 1 Popo bi } L59o00 HiiE : H LY EE 3 41 iyiin in 1i ] Fititg b I ofeuLt l  Ch Pol ; gi ] 3: 2i 2 i is | TEER 3 % ti E % it i | bol gH. ed 1 i jy 1! Phin Hh 1 deli ~& : { 3 & i i ii | 3 gx ; Pon io py i |: ii | i: g 11 . EE Ha P [Hpioh iIA; pHi)y it i If a 5 S i E LiL ; gHEf pHieH d oS o, ] BR old : io Ie fut i PEA i do pi ohunl : di gH. hl iFo Pog hbiiEe nod ) of i rpiadil ; : po | ||| 3 ili:i = iyPofy bEifYtl i iLfea wlihi iRENEnE. H HilH ly 1 ii bin oe lt] 1] : ogy 1H g : FEE gz: 3I cirh [HelM1s154p0 y 3 ai i3z Pioe Ioy ;5 7 ip i 2 gz 8 cod j i Pag ot io: thst i Po EB FE PEELE si, : Psitgea2d, . bir gia 3f:yos2 P PRi E gdt 3 LH I Pit 3 5; fF f3iEoi; poring 4 yu yIp, P f8og 1p 1hE1El 4a4s ELH 0 8 ol z gi : i Po iad i rf Ip of i ly hii i iii ! P bryepipilh 8 2% 3538 5 73 i3 i H 00E JHE | by 5 l28 S i cPH n idggs g id g PF Fee bd ] | i ;| i 3 ii 3 Poonl i : i ji 8 i ed [EE Lio all pb 4 | JH : gH 4g PHEEE HL ni | Po 4 ;i i | Pog | : ! 2g Ef lLA ifiPill H oii ld bot) g 1Po H Hn f3o8rsi, B ii | iLL . ipi| i: EfoH reI f i i gp:popo1f Bgiiiihtpny }: fprep aBipnid : PLsEdE[aidy PEE 2: P5 E o1g Hi3g:; BF : : joing dE: EB E sp 8 1g ipEf Hinlgbg i ~ g SE foal ip Cod i ii Hl i odot iythd e IF pbribl | ti Bi ib | f o a1 h f 1111 Salih PF aed ] ~ | i ii i i i | i Ti |2 7 2 i : id if fos , 11: i CH firy bfill i EH. i asihe; ii ] fil LI HEH : Ml HE i i ig Ed ~4 |3 | Pog : . i = | . ii 8 3 LE i 2 ;& 3 gpIxo 8bo EBitiRddE i I i i frig [EIE nai i fy ly 3 hy Hist 1 th 33 ffogc 1i FifHr if BE 4 iy BE i EEE Pir ME I~ |2 |1 i Pod eq] : i ii :[I jHE ul i3 Cd Lyd fg % Pst bEog. H ailied = J iD t oiE e p oioemim hi b 1 h oyp n 1 pia Ia i0r bEd 1i10n53 oe 2 3 3 P i i pd 3# 2: 8 aol i 1 [I TipRoLd ii i2 SERE53 ig $HPe giq, difgff 4 inh] HERE Loui i1%1.: mSliit hy 10 wig | IH I1g sgqP,ii orHrl niid 1i 1HEL ER di 8 i i: 1gi i| : Cid i Py pt TN :. ii fi :2 ig Byid reid gga! d JL;Ti i PoEP dsfRritEid difgpf kgyi.lfpeda PsER -!Lif H Mii | j Bigg ; :: ] ] } | a EL | Fool : | 3 = Co 5 : i : i PEG g Po fii I icgi ii IPi:t ir Hh . HyPoHeili g i Hiihe T: oii: gill ilg:e i": Eig : g2 Fy i2iiEnE 1 fgg 7 ; # Hilhiy |g FF Meer bd Cd x | g ;ILPod i iif i dopo | po 1 ii fIye i iHg Hif ;! JE5 5 $88 3 a ERE ot] c! oaS diHliHn Pboi hi boosie ~ 2 Po. 1 i pd 3 ie bi sd {i i| iy [I pipeo 0 ig 3 fy ihlll ig ig 5% g alin 23 i2 IsFlESl] Poi dg 3 ; tii ld : Palio J off JHE i { i i | : : oe i - .1 g Pon 1 i if i i io i 3 Eg 7 a id ig : 3 3z 1 8 gi atl fy EEE ie ii : 1 hth IPr 1dlHEnT : Fil 8 sisi gg P3s:ro gidfgis "oe | i i: fi iTifi PPorl ouHto if gg 1 peo hn iol 1d it H if $80 5 J ii HE 2 : HH biting 3 5 HH i TE] | i ir lini : |3 ! | a i . 8 oa] [IIE I i: CorTo dd ! itoe iy f dg ij IE |3 8 5g iif : EZ 8 it iil 3 it io i ii || i HE 2 : [0 i: gli ees i ip iatin } 1 Pog | oq i 1 hg 11 2 E 3 a : it i i Pog Hio t ii 501 abi HE gif 8 i: ERE ihe g gf 1:b2d Pony ggtf:f fiyly HEREsell i : bytiigg f g 8 FRE2E1 B AEH | I : mE dh Ci EE in| iH Ie HR iiE:EEt1iT8l1 yh: hiEG i tH Al i i : aHI | Prati || || ! | BE 5 sd 8 iJ t 3i id iE 2 i 1 Gol ha i : : B sf ii ys3 i i g PE Sg i : | g23id H8 E8 | ER gif 1: b 4 "5o: ohn pi : 1 i RFiIfi Ibl ] g Elin i i | 3: s dr liHni i : - {1 i i! i 1: i i SY i g il i Hi HE cif fi j P od i i Fring : SEH | | | g f ; 2 5 od ! 3 ii 1 [I i LoF3 og| figy 1df 3] LH) fos I I" Ey Ha} 8 HEis H aiEidRE SE desi: hi dhe PERERA. FEE ih With p UDoEn # ) EE IR :oo B lg E HEGT |g PE ad a: : ii 8 Lo phil 1 Pt 2I 5n8oi iE i yf ifzp 18f }3 iPteog01gg, MaHHEhI] :I Hi La J i! i W did i1! e06 I b1s: gailg idu es : BET 0 . pooh digg i cFaoil, ogHiEitEe P 1 oiop hFrHa n id 2 i Pl i [I 3 : if i 3 PPE ot Ijpi ii i0to 1 idnh : fBoigrd0 oggiidido g pFEL hy cLiipl i35 iFFE: E5ox [H:ifSsE st bo H HI e ibe ni | 1 iF Bik ~ g5 ;i 8| HEi HE ; } ii ifyyadi i Fol omni zsfo g eo ; fFiyr EH gfi , fy id Al iil gHisEt iLE LgOs EE ARH | Php lig : FI Ed i ilef HBEHE 8 SH ows i g} cl HE | gl fel 5, Po 1 Hl Wy hrc IE HIN J fFR p HH EEYE ote i | HI | : ) i al HIi B88 53 PE 4 jplEliingn 2 i | . i: i pi i: 7Po fiodl iI 8 bg fy 2 omg iF Hl Colby dy fy 2 3I:% giIg EiElEa Hy Lda 44 G.3 i me dr ih 1 10 BHE al ] 2Phy sai#8 i cei, HE a i PL i 3 ; i Mellin ~8 Le adi i i Po Pog id 18 rod ju i fF al Pleogfgde i $dy giE g]E ee i 2 Efid Hgieitll i un Hl fu iy 1: & Fl HE PE oes fEo S Hn L ;i i i i : i "og : 5 i j| : Ly dad i rg i H: f5 : io } 5TPodgg i i3 g 1f1t : I gi 11 il pF i iif = i 252 3 if : 8 fipr RI 3I2 EEiiEdd MaEH L HH H Ba Eg3Hi ol : BEE 23 gj lebih ibo Pi l | i iro ; IN TH i Pod ji Hl Lc eo bWf i i bse Dore fl : i will Io, Mh 1opeli iP88 2: olan |8 iigEs ! R FLH :i poPo i : i: iif ]i HI 111 i iol if, 53 iid i: fife pore ly I.i 1ilHl Palm or, Hh : fd IR 3 fa igt te dh r FEF peril i ~ yg |g . 3 i. Ei o 5i Poon ; i iz ; 3: SE | EPo 01 jt iil i s$0 h oBwg eEgiid 2 pHrl. H EEN aItE :iy g Lharaid l gose d fi Blige: 0: poi HEH 2 i bouE pPg my 88d2:2 dad Hh |g LP FPeedil ; o id gi CPl oE | ii io ji i fob dl I HEHE FIREi:hr i a h : 5: hd Io HH :EE3ooR aiiE i dl * | ER HH E ~3g 2| : . gi : i i4 5 Hr E fFI i] od i i i io pil i f2e 1 hiil :t ro gid ig: gif it J Pit iBil] T g1 o4sil Hgiindtl : i fh gen gn 2 PoE og 33 3 Pp liinip : . i; f4 P 1 oiyd Pod Li i TiPEopRo8 i i gf i bill HN EE hal 4h gj; if Fsoogdiilriid ig cp jg E | 1{40 psirahiniRensE 8: i 5 i 5i : i r= g| g 1i hiidl 5 ] Pon i 3i o3 gf111 iz i, Hhi H :. b2gon si 3% ic i] EiE s a yh l 4 ii 3oor8 e[dBiiEtE : | Agin 18F 22 IdEo R chHiEnEa i PE laid f TM gi 8 iol i . 1 id 8i : ;i i 7 Hd $ fo Ep g Tigb iig td i SELH i |H g5 PbiioEgE i HE ~ i gFiH] F J| L ii:fs oHcay gE}BH 41: Lifal z i ji Ef : Foiiing ggf S EsEiefSib HigiBf 3 oA o, i :i8 nL pPybcoogiqhp ii: BF ata I~ inFy Hjiis 8 ) gH, ial C ooi: ngoinn? | hill 3 E 32 2 gd g ` i BBE 23 RE RNIRE 1 ir fEinl ; i 8 pol i 8k ip i FE io i de di LEOpf ai if i if, ERY fi . Eo id 54 ' He = ipo HFiHn i dShriidnok .1 { 3 BE ; i 1: ] Po! oipon i Cl pot piotahhl . EHH i! EE ji, i pH : iid :diffl hiii alh ] 8 ipo ]i Big: ji iPoo[d| i i dPoobg id|g| ial iiz IHEe Hyi : loin gL, Linh 5z ig iii gIif 2: on i ip oiik g C0 1 | [I 1 | fo OR Hih yd i || | ih ie| ; HH : fly ei o| qRiyE MitJigii | Pir BE Cog : Poi | Pso o1 g dl 2i 1 18%! ! pH sop Thin |i do Th | ERE ioe piri 5 Hr gia i: J qi ill Pg BE { dyn 3 gE EE gx iBERE i % Pslp lEhdiLaeps ] Po : : ol | BH HH SE Po fil i gob ii | LGle fHolire | IIjh m1ai Het Pad o5 i leg J fi BEf 5: fishin | 31 3popc: REEE E JiE gs | "og P. or, i :; La EH P1tooaHiE pegd Ji Hi phi Hgln ee poi dni s gd EI 2: ;oFoaiddaepit:l : 2 hk fp RiRlp - z sd 8 3i i!i 12 Pb : ydi 1 i ii 3 ef, 3 iyi |2bog Ht ERE ii I fPpe foaiB,lpl ' 1 pte Jd (isPE gEii] af o =p:be Bein gel 2 e: l HELL hia . 3 Fl ggig i ir leigh i1 ts pif tEmERhE "3 3 j : i Pd Po : Eo ot I 3: 1gs i 35 i io ] 32 jiu iff g oo fgfy, 1iHis Hd a jBEp:4 LBiiagiii idl i :i38 : 4 fHdEhiEeig]igl geef FI eto 1 i hy rngEOE j cE, ili pooh ; Cl P Po pp i | i eiy g: g: hifo] ;$ Fl gill tHIn Wdahlll ]Lo g f3, HELD |Poiiiy, l Hh h EH is 3I oE se, L HL23 a |3 1 i HER i 3} H[I E 8; bRioIEda fi iis d fEHgi 2IffRlEgt P1 d ofdpe, l BEnE HF j Py i Pigg: 3z F ip i len liai gp  5 2 : i | i po : : i! i 3 i 3 iLE ol ii[I a i Pi g LE g 5 F H SEeE RE 3 ! Lili Ii, hin fgi ipd` diaBeloreis g8 f] 5 fpreroemr i gio ir m Bh h ig i mH ] 1 dp in 5i ER E 3E i; I oee 5 Pe feet i 8 Poy coi ; gpPPLlo1 ogaidnnyl : e pi pi i : EH ; 18%; ! ER P43o1fi:F, dCtdrnpisotl 1 Print ' 2 j 8 E82 | I d: SE E hR eiI R lE ee I~ gl 3 3 .! Ppli 1 1 ; vol ig ig 8 i i 3 HHF111 JEN PLEr BHyate HH J i: aiebe 1o3 dFeR 1, MiE u ghar ch) sd } i fhe aiiie 3 gait - ii : 1 i i : : : Po {i i i pl i ir og 2 3i 1 i i irk peti 2 g sl 311 i Lt hb : L HL E b nial gLiL h1 a E iid l h51 odin {TM EH : 3i : Cas nBidda J sErbg i po pig i ld ; gi ; Eh i: BERER 3 : g he i iI1py, fii TINE ig Pid 5: | 3 lirgfied Hhin : 8 i 3 [HI i ipo BELio ii Codd i gP Pro boa oan i 5, gif de 8 EHEE HIH P0E , gi ig oi Had | : ; BEF 2: i El 1 ir linie