Document b8x0vqMnxdb8y1b1EdO5kjko

EXLTROXMEXTAL HEALTH nailer Than Screen Siiei into Graded tnduiir. Hyg. & Toxicol. 11:2-15-236 ,E. B.: Cotorimeiric Determination Metals, Ed. 1 New York, Inter hen, Inc., 1950 nn, H. .1, and Grogan. C. H.: L'ni, National Cancer Institute. I Encyclopedia of Organic Chemby E. Joseph}- and F. Radt, New am, Elseiver Press. Inc., Vol. 14, p- 45". nn, I, and Schoental. R.: The ' 3,4-Benapyrene in Mice and Rats, Hydroxy and Ouinone Derivatives tion of Their Biological Significance, 1:145-158 (March) I94J. Falk, H. L.; Lijiruky, W, and -: Inhibition of Scene Carcinogens wtially H>-drogenaied Derivatives. S (Jan. 20) 1956. . T.: Stangtr. D. W.; Pino, A.; buhik, P, and Wartman, W. B.: 9,10-Dimethyl-1,2-Beruanthracene *is in Mice by Polycyclic Hydror Res. 11:892-897 (Nov.) 1951. C Asbestosis and Carcinoma of the Lung !! Case Report and Review of the Literature lOSSN AfSOttSOSS, IU, m4 flAMCIf A. CAMPAOS4A, M.O~ Sm grandee* I'ueumonoconiosii and, in particular, as- la-smsis have been the subject of many >>>ni|>lrte re]rts as to etiology, prevalence, vti-.1 However, the coexistence and possible relationship of asbestosis and carcinoma of die lung has been re|X>rted rather infre- iiuently.'-11 In particular, there are only 23 ciscs of asbestosis and lung carcinoma with I'muplete autopsy re|x>rts that have been documented in the literature: Is>elbacher 11 r<-|irtcd 21 cases, TntM! rc|<orted 1 case, and Lynch1 re]iorted 1 case. Lynch relirted two cases but only one with autopsy hndinfs. Doll* rc|*orttd necriipsies on 105 -i-liestos workers, in which 18 had lung carcinomas, 15 of which were associated with asbestosis: complete autopsy data was ""I given. Kare reports, as the one by Cartier,12 attempt to disprove any relationship bet'vvvii the two conditions, but not enough '-'"relation is presented in this report for evaluation. Report of Cate -'year-old white man of Italian extraction -linitied to St. Mary's Hoepital on May 8. " His chief complaints were shortness of 1 un exertion anil loss of appetite of four >e months' duration. He rlenied noriunesl ca or ankle edema. He admitted, however, to vtinte cough for approximately six months - h was productive oi yellow mucus. Tltere : also two bouts of hemoptysis of minor degree and six months prior to entry. On each ' "ii they lasted two days and were intermit*1 t,T. '(veived for publication Sept. 17, 1959. "dstant Resilient in Medicine. Second Medical *'*'**. St. Mary's Hospital (Dr. Anderson); 'ending Physician, St Mary's Hospital (Dr. Lnnpagna). There was a JO lb. weight loss over a six-month period .iiul considerable fatigue. He also noted clubbing of his lingers for "some years." For JO years the patient Itad worked actively as an asbestos insulator, working both inside and out and in new and old buildings. Tins entailed cutting, molding, and applying asbestos insulation tu pipes, boilers, etc. At no time liad lie or ills associates worn any protective mask. He had worked full-time until one week prior to hos pitalisation. He also had considerable contact with l-'iherglas. He had not smoked in the past five }<ars. lut prior to tltat he had smoked three lvk:icc* of cigarettes daily tor many years. There wa. a moderately heavy alcohol intake, primarily wine, in the past six months Family history was negative ior malignancy There was contact 20 years previous with a brother who had tuberculous. - I'liv Meal examination revealed an extremelv vm.iviaicd and dyspncic whitc man. appearing ilironically ill. The blood pressure was 140.100 In Ivth arms, pulse 84 and regular, temperature IU04 rcctally, respiration 24. height - ft 10 in., weight I22b$ lb. There was marked clubbing of the fingers and trx> liut no cyanosis. There was I-laiera I arcus senilis. No abnormalities were noted in the neck. The chest showed rerlueesl excursion in l->th lunc held*. Dullness arxl loth ileeteased hrraili >uuipU and fremitus were noted on tlie right involving the entire lower halt of the lung field Medium dry rales which did not clear seerc heard anteriorly and posteriorly in the interior areas of loth lung>. The heart was not enlarged to percussion or palpation, ami no murmurs were present. There was a split first staind at the apex Complete examination otherwise was within normal limits. Laboratory studies on entry showed a Hg of IJ Rficgrrv; 4.58XKF; WBC 8.850. with poly, morphonuclears 78. nonsegmemers 7. lymphocytes l1), monocytes 2, and eosinophils 1; FBS 112 nig.; RL'N 16 mg.; serum albumin J.5 cm ; globulin J.l gm.; thymol turbidity, arid phospliatase. direct ami indirect bilirubin, amylase, ami clccirolyte panel -were normal. The alkaline phoapliatase was 6.5 and 5.9 Boilantky units 1X1 two occasions. Urines shewed persistent 1+-24- albuminuria. I.E.-cell preparation, Kalin and Kolmer, ami bloat J9/27 SCF-FA-4865 PQ8004 0030 HFM -011691