Document b8qpX9DVZqM7xGrgGZK26Ydk
mie, M ath Physics
3M Medical Depariment
pgsaeese ec, Building 20.25
S6t12Pa7l5, M11N1055133-3220
R2)6-000Y4
Radiolabel Oral Absorption and Intravenous Pharmacokinetic Studies
Aadbmsionripsttieorne:d tAottwleoasgtr9ou5p%s o(2fa4 hsoiungrleanodra4l8dohsoeuravsaecrraigfiinceg)4o.2f3mgm/alkeg C[hCarJlPeFsORiSver CD rats (248-315 g, mean = 285 g) was absorbed within 24 hours (Johnson and Ober, 1979). `lTishteedrabdeiloocwhewmiacsa>l9p9ur%it(yJoofhtnhseon['an*dC)BPeFhOr,S u19s7e9d).in this and the other radiolabel studies
DCihsatrrliebsuRtiivone:r CBDy m8a9ldearyastsaf(tienritaiaslinbgoldeyiwvediogshetosf26P2F-O3S03-"g,Cm(emaenan=d2o8s8e,g)4.e2xcmrge/tkegd)asix m12e.a6n%.ofA3t08.92%doafyts,hemetoatnaltcisasrubeocno-n1c4envtiraautriionneo.ftMoetaalnccaurmbuolna-t1i4veexfpecraelsseexdcraestipogn PwFasOSbYoCneeqmuairvraloewn,ts0/.5g. weLreo:werlivceorn,c2e0n.t6r;atpiloanssma(,<02..52); wkeirdenemy,ea1s.u1;reldunign, a1d.r1e;nsapllse,esnk,in0,.5t;esatneds, mliuvsecrlaen,dfaptlaansdmaeyree.preNsoenrtasdi2o5acatnidvi3type(r<c0e.n0t5o)fwatsheddeotseec,terdesipnecbrtaiivne.lyT(hJeohcnasrobnone-ta1l4, in 1979).
Mhaevteabboeleinsdmo:seAdnawliytshispebryflLuCor/oMoScotafnseseurlufomnaatnedhlaivveernsoatmrpelveesalferdomansytuedviiedsewnhceeroefanimals
metabolism. There is no known perfluorooctanesulfonate.
mechanism
for
the
metabolic
conversion
of
Excretion: In the previously mentioned study (Johnson etal, 1979) single intravenous
d8o9sdeasy(smaefatenr4d.o2simngg/,k3g0).o2f%o[f't/hCJePaFdOmSininis0t.e9re%dN'aCClhawderbeeeandmeixncirsetteerdedinttohmeaulreinreatsa.ndBy
12.6% had been excreted in the feces.
`Whole body elimination in the male rat appeared to be biphasic. Initial redistribution
from the plasma yielded a plasma elimination half-life of /C of 7.5 days following single
o1r9a7l9)a.dmiInnitshteraatfioorneomfe[n't`ioCnJePdFiOnStr(amveeannoudsossteud4y.,2 emlgi/mkinga)titoonmaofleonrlayts4(2J.o8h%nsoonf athneddOobseer,
through body is
urine and > 89 days
feces in the
after male
$9 days rat.
indicates
that
the
half-lifeof
elimination
from
the
1
000017
..
3MIneMdduiMscteirdniieac,laHHleyDaglietephnaePr,hmyTesoinxcitsc:ology
730M Cbeonxte3r3,2B2u0ilding 220-28.02 S6t12P7a3l5 M11N1055133-3220
cFheocallesatnydratmoitanlee(x~cr2e.t7igo/nkogf/d)'*iCntwheeriredimaertkfeodlllyowiinncgresaisnegdleininmtarlaevernaotsusaddmoisneissotfered
P['FCOISPF(JOoSh.nsTohneanredsuGlitbsssoung,ge1s9t80t,hat19t8h4e)r.e
wCahoslseisgtnyirfiacmainnteenatdemrionhiesptaetriecd
circulation of
at 4% by weight
cienllfseeadndtoimnaclreearsaetdstdheecreeliamsiendatthieonroeftecnatribonono-f1c4arvbiaonf-e1c4esinafltievreri,vpdloassimnag,waintdh rPeFdObSl-oo1dC.,
`Groups of five rats (twelve-week old Charles River CD averaging 320 g) were dosed
idnotsreadvesniomuilsalrylywibtuht PwFeOrSe-n'o*tCtr(emaetaednwdiotshe,ch3o.l4emsgt/ykrgam)i.neG.roRuaptssowfefrievesaccornitfriocledraatts2w1edraeys
post dose. The mean liver,
urinary excretion of C for
plasma, and red
cholestyramine-
blood cell
treated rat
c
s
oncen
were
tration as
compared
well as f
to mean
ecal and
control
r(a0t.9vualgu/emsl.),Maenadnrecdhoblleosotdyrcaemlilsne(-0t.3rega/tegd)rartep'r*eCsecnotnacdeenctrraetaisoensfirnolmivmeera(n9.c4oungt/rgo)l, rpaltasma
concentrationsof3.8, 7.7, and 6.0 fold, respectively. Fecal elimination (75.9% with
cholestyramine treatment) asa resultofthe relatively
was increased 9.5 high rate of fecal
fold. The extent of urinary "*C eliminationof ""C was lower in
elimination,
chhioglheesrtiynratmhienceh-otlreesattyerdamraitnse.-tTrheeateexdteranttso.ftSoitnacle eclhiomliensattyiroanmoifne""iCs a(purpirnoevpeldusfofreucsese)iwnas
chhuomlaensstyarsamaicnheolineshtuermoalnlsowteorpirnogmaogteente,xctrheetsieorneosufltPsFiOnSat(sJoshunpspoonrtetthael,c1o9n8c0e)p.t of esting
2
000018