Document b5j4LNyQmd8xG38K1beZjrKV6

ii-/4Dio: suDcnromc toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations TRADE SECRET Study Title H-24516: Subchronic Toxicity with One9-G0-eDnearyaGtioanvaRgeepSrotudduyctiinonREatvsaluations Volume 3 of 5 Laboratory Project ID: DuPont-5386 DuPont-5368 AR226-3199 Test G u id elin es: U.S. EPA Health Effects OPPTS 870.3100 (1998) Test Guidelines Author: Gregory S. Ladies, Ph.D., D.A.B.T. Study Com pleted o n : December 3, 2001 Perform ing L aboratory: HE.aI.skdeullPLoanbtodreatNoreymfoourrTsoaxnidcoCloogmypaanndy Industrial Medicine Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 W o r k R equest Num ber:' Service Code Number: Sponsor Study Number: CompanySanitized. Does not contato TSCACBF Page 629 of 1500 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX E INDIVIDUAL CLINICALAANNDDMOOPRHTTAHLAITLYMDOALTOAGICAL OBSERVATIONS 630 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA EXPLANATORY NOTES Critical Dates Day 74 Male and female rats designated for reproduction evaluations were co-housed aOnbdsearrvearteiopnosrtreedcaosrd"erdemduorviendgftrhoemcoshtuadbyit"atiinonthaisndapppoesntd-mixa.tiCnglinpiecraiol ds are reported in the Reproductive Toxicology section. Day 80 dOapyhethxaplomsourloegpyereixoadmainndattihoensonwee-rmeocnotnhdruecctoevdeorynpraetrsiodde.signated for the 90Day 91 Male rats designated for the 90-day exposure period were sacrificed. Day 93 Female rats designated for the 90-day exposure period were sacrificed. Day 122 Ophthalmology examinations were conducted on rats designated for the one- month recovery period. Day 125 Msacarliefiacnedd.female rats designated for the one-month recovery period were Day 181 Male and female rats designated for the 3-month recovery period were sacrificed. Any clinical sign observed on consecutive data collection days is assumed to have been present dpuerriiondg fthroeminttheerimfirbste-tlwasetednayobosbesrevravteiodn. dOapyhs,thaanldmwoliollgbyeErveaplouratetidonasohbasverinvagtiboenesnaonbdseCrlviendicoalver the Pclainthicoalol goybsEevrvaalutiaotinosn. sAarlleodpohctuhmalemnotelodgays oCblsinericvaaltiOonbssefrrvoamtiotensst adnadysin8t0erorrup1t2t2hearceotnhtoinseuionbgserved during the examination by the veterinary ophthalmologist. CompanySanRfced. Does nntCn,,*aS,, r e * 631 SanRled, Does no contain TSCCBS # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________ INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MI MI MI 643241 643300 643143 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Wound, Superficial, Shoulder, Right Sacrificed by design Right 0-42,49-77,84-91 91 44 80 91 0-42,49-77,84-91 44,91 80 91 0-28 44,91 80 35-42,49-77,84-91 91 MI 643205 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643235 General observation, No Abnormality Detected - Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643288 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643150 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 MI 643189 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 MI 643185 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-77,84-91 91 44 80 91 632 # DuPont-5386 # H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations DuPont-5386 Sex Group Animal MI 643210 MI 643268 MI 643232 MI 643265 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Eye right. Black Sacrificed by design 0,7,14-28,35-49,84,90,98,105,112,119, 140-154,161-181 55,101 9,96,108,139,160,181 0-3,21,34,76,89,92,115,125 56-70,77,126-133 181 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right. Black Sacrificed by design 0,7,14-28,35-49,63-70,112,147-154, 161-181 34 9,55,76,89,92-96,101,108,139,160,181 0-3,21,115,125 56,77-84,90,98,105,119,126-133,140 181 Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forepaw, Bilateral Feces, Present, Brown Sacrificed by design 3,9,21,101 55,96,139,160,181 0,34,76,89,92,108,115,125 0,7,14-28,35-49,56-70,77-84,90, 98,105,112,119,126-133,140-154,161-181 21 181 General observation. No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Bilateral, no blood Eye Observations, Bled via Orbital for Clin Path, Bilateral, bled by tail vein Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Left Eye Observations, tail vein Discharge, Nose, Black Discharge, Eye left, Black Hair Loss, Face, Left Sacrificed by design 0,21-28,35-49 119,126-133,140-154,161-181 77-84,90,98,105,112,119,126-133, 140-154,161-181 56-70 9,21,55 101 108,115,125 0-3,34,76,89,92-96,139,160,181 147-154,161-181 70,77-84,90,98,105,112,119,126-133, 140 160 7,14 56-63 70 181 CompanySanitized. Does notcontain TSCACBI 633 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal MI 643239 MI MI Mi MI MI MI MI MI 643270 643148 643284 643229 643196 643176 643218 643207 MI MI MI MI MI MI 643280 643271 643211 643163 643197 643242 Observation General observation, No Abnormality Detected Hair.Loss, Shoulder, Left Wound, Superficial, Shoulder, Left Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation. No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study .General observation. No Abnormality Detected Removed from study General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation. NO Abnormality Detected Removed from study General observation, NO Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study SanFSfied Dees rco eomasrs TSCA CBS 634 OBSERVATIONS AND MORTALITY DATA Days 0,21-74 14 7 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-35 42-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 m 90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Sex Group Animal MI 643251 MI MI 643155 643147 MI 643276 MI 643237 MI 643226 MI 643195 MI 643246 MI 643253 MI 643262 MI 643172 MI 643303 MI 643304 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Observation General observation. No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected Hyperreactive No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design Company no? nncnnta'nTSCACB1 635 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-74 74 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-112 119,125 80,122 125 0-77,84-119,125 80,122 125 DuPont-5386 O O m 4 0 1 1 3 5 /> ft H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations # DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation MI S431S2 General observation, No Abnormality Detected General Teeth Observations, Clipped Hyperreactive No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design MI MI 643254 643145 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Eye Observations, Closed, Left Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left MI 643204 Eye Observations, Eye Observations, Eye Observations, Eye Observations, unable to bleed Eye Observations, Exophthalmus, Left Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Corneal Opacity, Left Left Right Right, Eye Observations, tail vein Discharge, Nose, Black Discharge, Eye left, Black Discharge, Eye right, Black Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-35 58-77,84-119,125 112-119,125 80,122 42-77,84-105 125 125 0-74 74 0. 181 84.90.98.105.112.119.126161-175 133,140-154, 14-28,35-49,56-70,77-84,90,98, 105.112.119.1266-7 133,140-154,161-175 3,92,125 0,21,34,55,76,89,96,101,108,115,139,160,181 9 14-28,35-49,56-70,77-84,90,98, 105.112.119.126- 133,140-154,161-175 160 35 7,56 77-84,90 181 0-42,49-77,84-91 91 44 80 91 tsccb 636 CompanySanNteed. Does noteoata'nYSCAC8I H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________________________ Sex Group Animal M III 643173 M III 643290 M III 643272 M III 643292 M III 643228 M III 643308 M III 643264 M III 643240 M III 643180 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-77,84-91 91 44 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Sacrificed by design Bilateral Right 0-42,49-77,84-91 91 44 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 0-42,49-70 44,91 80 77,84-91 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77, 84-91 44,91 80 91 637 # DuPont-5386 A ^ n -2 4 5 16: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation 643179 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 643202 General observation. No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left Discharge, Nose, Black Sacrificed by design Days 0-42,49-77,84-91 44,91 80 91 0,7,14-28,35,70 56,140-154,161 34,55,89,92,115,125 9,21,96,139,160,181 0-3,76,101,108 77-84,90,98,105,112,119,126-133, 140-154,161-181 42-49,56-63 181 643310 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Discharge, Ear left, Black Discharge, Eye bilateral, Black Discharge, Nose, Black Stain Fur/Skin, Face, Black Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right 643306 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Ear left, Black Discharge, Eye left, Black Discharge, Eye right, Black Hair Loss, Forepaw, Left Wound, Superficial, Face Wound, Superficial, Nose Sacrificed by design 0,7,14-28,35-49,56-70,77-84,90, 98,105,147,181 3,55,139 9,21,92-96,115,125,160,181 0,34,76,89,101,108 126 133,140 112,119,126-133,140,154,161-175 119,126 181 0,7,14,28,35-42,56,70,77-84,90,98,105, 112 119,126-133,140-154,161 3,34 9,55,96,115,139,160,181 0,21,76,89,92,101,108,125 126 133,140-147 63 140-154,161-181 21 49 181 CompanySanftteed. Pos 638  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Sex Group Animal M III 643305 M III 643293 M III 643287 M III 643188 M III 643230 M III 643170 M III 643144 M III 643277 M III 643214 M III 643261 M III 643166 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Breathing Observations, Noise Discharge, Eye left, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,90, 98,105,112 160,181 9,21,55,96,101,108,115,125,139 0-3,34,76,89,92 119,126-133,140-154,161-175 147-154,161-181 126 181 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right, Black Hair Loss, Forelimb, Bilateral Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,90, 98,105,112,119,133,140-154,161-168 9,21,55,96,108,139,160,181 0-3,34,76,89,92,101,115,125 126 181 181 175 181 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study 0-14,56-74 21-49 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Hair Loss, Forepaw, Right Removed from study 0-21 28-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation. No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 # DuPont-5386 AtitiM5^ i16^ ^ w ss 639 f _ 9H0--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation M III 643153 General observation, No Abnormality Detected Removed from study M III 643177 General observation, No Abnormality Detected Removed from study M III 643198 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Wound, Superficial, Tail Removed from study M III 643291 General observation. No Abnormality Detected Removed from study M III 643184 General observation, No Abnormality Detected Removed from study M III 643167 General observation, No Abnormality Detected Removed from study M III 643223 General observation, No Abnormality Detected Removed from study M III 643233 .General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Removed from study M III 643183 General observation, No Abnormality Detected Removed from study M III 643219 General observation, No Abnormality Detected Removed from study M III 643263 General observation, No Abnormality Detected Removed from study pSijJjWSS /A5dffi@g) 640 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-14 21-49 56-74 21-74 74 6-74 74 0-74 74 0-74 74 0-74 74 0-49,74 56-63 58-70 74 0-74 74 0-74 74 0-74 74 i DuPont-5386 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Sex Group Animal 643250 643243 643311 643318 MV 643247 MV 643175 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Hair Loss, Thoracic, Ventral Mass Thoracic, Lateral,Mass #1, Ulcerated, 1.5 cm Mass Thoracic, Lateral,Mass #1, Not Ulcerated, 2.0 CM Mass Thoracic, Lateral,Mass #1, Not Ulcerated, 1.5 CM Sacrificed by design 0-42,49-56 44,91 80 91 84-90 77 58-70 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Breathing Observations, Fast Breathing Observations, Labored Discharge, Mouth, Red Discharge, Nose, Black Muscle Tone, Decreased Pale Comments, excessive toe nail bleed Comments, 2ml blood Stain Fur/Skin, Inguen, Brown Stain Fur/Skin, Perineum, Brown Stained Cageboard, Red, alot ofred from toe nail Accidentally Killed 0-42,49-56 44 77 77 66-76 63-76 73-77 73-77 76 66 77 73-77 73-77 77 DuPont-5386 CompanySanitized. Does notcontain TSCACBI 641 # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations # DuPont-5386 Sex Group Animal MV 643314 MV 64327S MV 643257 MV 643224 MV 643169 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Absent No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77 44,91 84-91 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 91 44 80 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44,91 80 91 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Partially Closed Eye Observations, Enophthalmus, Left Eye Observations, Eye Observations, Eye Observations, Eye Observations, Eye Observations, by tail vein Eye Observations, Exophthalmus, Left Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Corneal Opacity, Left Bilateral Left Right Right, bled Discharge, Eye left, Black Hair Loss, Face, Left Swollen Observations, Face Sacrificed by design 0,7,14-28,35-49 133,140-154,161-181 119,126 77-84,90,98,105,112,119,126-133, 140-154,161-175 56-70 55 9,21,115 0-3,34,76,89,92-96,101,125,139,160,181 108 77-84,90,98,105,112,119,126-133, 140-154,161-175 56-63 70,77-84,90,98,105 56-70,77-84 181 SsnMzed. Does neeonSafjsTSCCBS 642 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days MV 643159 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbitalfor Clin Path, Left Eye Observations, Bled via Orbitalfor Clin Path, Right Eye Observations, Corneal Opacity, Bilateral Eye Observations, Corneal Opacity, Right General Teeth Observations, Maloccluded General Teeth Observations, Clipped Hyperreactive Discharge, Eye left, Black Discharge, Eye right, Black Sacrificed by design 0 161-181 9,21,55,96,108,139,160,181 0-3,34,76,89,92,101,115,125 175-181 7,14-28,35-49,56-70,77-84,90, 98.105.112.119.126- 133,140-154,161-168 119.126- 133,140-154,161-181 77-84,90,98,105,112,119,126-133, 140-154,161-175 126-133,140-154,161-175 126-133,140-154,161-168,181 35 181 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye left, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84,90, 98,105,112,119,133,140-154,161-181 126 3,21,55,96,108,115,125,139,160,181 0,9,34,76,89,92,101 126 181 643181 General observation, No Abnormality Detected 0,7,14-28,35-49,56-70,77,82-84, 90 Eye Observations, Bled via Orbital for Clin Path, Bilateral 0 Eye Observations, Bledvia Orbital for Clin Path, Left 9,21,55,76,89,92-96,101,108,115,139,160, 181 Eye Observations, Bled via Orbital for Clin Path, Right 3,34,125 Eye Observations, Corneal Opacity, Right Comments, compound evident on lips 98,105,112,119,126-133,140-154,161-181 81 Sacrificed by design &*m 643206 General observation, No Abnormality Detected 181 0,7,14-28,42-49,56-70,77-84,90, g Eye Observations, Exophthalmus, Right 98,105,112,119,126-133,140-154,161-181 35 Eye Observations, Bledvia Orbital for Clin Path, Bilateral 76,108,115,125,139 Eye Observations, Bledvia Orbital for Clin Path, Left 3,9,21,55,96,160,181 v3 Eye Observations, Bledvia Orbital for Clin Path, Right Discharge, Eye right, Black 0,34,89,92,101 35 Sacrificed by design 3 181 O MV 643313 General observation No Abnormality Detected 0-74 o Removed from study 33 MV 643182 General observation, No Abnormality Detected 3 Removed from study 74 0-74 74 Hi CO 643 # H90--2D45ay16G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations_______ Sex Group Animal MV 643146 MV MV MV MV MV 643312 643199 643267 643216 643244 MV MV 643245 643301 MV MV MV 643200 643255 643157 MV MV MV 643238 643227 643164 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Observation General observation, No Abnormality Detected Hair Loss, Forepaw, Right Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Hyperreact ive Removed from study General observation, NO Abnormality Detected Removed from study General observation, No Abnormality Detected Hair Loss, Forelimb, Left Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation. No Abnormality Detected Hyperreactive Removed from study General observation, No Abnormality Detected Removed from study General observation. No Abnormality Detected Removed from study General observation. No Abnormality Detected Removed from study SanWzed. Does jW -*"><ts<*a om 644 OBSERVATIONS AND MORTALITY DATA Days 0-70 74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-14,63-74 21-56 74 0-74 74 0-70 74 74 0-74 74 0-74 74 0-49 56-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations Sex Group Animal MV 643154 MV 643156 MV 643208 MV 643190 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation General observation. No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study Days 0-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal M VII 643194 M VII 643252 Observation General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-42,49-77,84-91 44,91 80 91 0-42,49-70 44,91 77,84-91 80 91 643260 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Wound, Superficial, Shoulder, Left Sacrificed by design 0,42,49-77,84-91 44,91 80 7-35 91 643315 Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Sacrificed by design 44,91 84-91 80 42,49-77,84-91 0-35 91 643215 'General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Stain Fur/Skin, Forepaw, Left, Red Stain Fur/Skin, Perineum, Red Stain Fur/Skin, Face, Red Sacrificed by design 0-42,49-63 44,91 77,84-91 80 70 70 70 91 643193 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Comments, compound present on mouth Sacrificed by design 0-42,49-56 44,91 57-77,84-91 80 57 91 VII 643298 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Swollen Observations, Nose Sacrificed by design 0-42,49-77 44,91 84-91 80 84 91 DuPont-5386 sopany ga7?j7s>#s. a TSCA CBI 646 [-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations % DuPont-5386 Sex Group Animal M VII 643201 M VII 643259 M VII 643174 M VII 643283 M VII 643149 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Misshapen Observations, Tail Sacrificed by design 0 44,91 84-91 80 7-42,49-77,84-91 91 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-56 91 44 57-77,84-91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91 44 91 80 91 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Broken General Teeth Observations, Maloccluded General Teeth Observations, Clipped Discharge, Nose, Black Sacrificed by design 0,7,14-28,35-49,56 76,160 9,21,55,96,108,139,181 0-3,34,89,92,101,115,125 70 58-70,77-84,90,98:105,112,119,126-133, 140-154,161-181 58-70,77-84,90,98,105,112,119,126-133, 140-154,161-175 112,119 181 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right General Teeth Observations, Clipped Hyperreactive Discharge, Nose, Black Hair Loss, Forepaw, Bilateral < Sacrificed by design 0,7,14,181 101 3,21,55,96,108,115,125,139,160,181 0,9,34,76,89,92 119,126-133,140-154,161-175 133,140-154,161-175 112,119,126 21-28,35-49,56-70;77-84,90,98, 105 181 j q g ^fOS.- W I S J W 9 JSHl S30f '0*lSU 647 -tflSPfc. --. H-24516: Subchronic Toxicity 90-Day Gavage Study in:--Rat-s--w--i-t-h--O--n--e---G---e-n-e--r-a-t-i-o-n--R--e-p--r-o-d--u-c--t-io--n--E-v--a-l--uat-i-o--n-s----------:_______________ _____________________________ DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal M VII 643178 Observation General observation, No Abnormality Detected Eye Observations, Partially Closed, Right Eye Observations, Enophthalmus, Right Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Bled via Orbital for Clin Path, unable to bleed Eye Observations, Corneal Opacity, Right General Teeth Observations, Clipped M VII 643152 Discharge, Nose, Brown Wound, Superficial, Mouth Sacrificed by design General observation. No Abnormality Detected M VII 643295 Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Discharge, Eye right, Black Comments, compound evident on mouth Sacrificed by design General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped M VII M VII 643289 643171 Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Discharge, Nose, Red Discharge, Eye right, Red Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Left Stain Fur/Skin, Perineum, Red Stain Fur/Skin, Periocular, Right, Brown Removed from study Days 0,7,14-21 119.126- 133,140-154,161-181 77-84,90,98,105,112,119,126-133, 140-154,161-181 28.35- 54,56-70 9,55,76,89,92-96,108,115,125,139,160,181 0-3,34,101 ' 21 28.35- 54,56-70,77-84,90,98,105,112, 119.126- 133,140-154,161-181 54,56-70,77-84,90,98,105,112,119, 126-133,140-154,161-175 28 28,35 181 0*7,14-28,35-49,63-70,77-84,90, 98.105.181 55,76,89,92 9.21.96.101.108.115.125.139.160.181 0-3,34 112,119,126-133,140-154,161-175 56 10 181 0,7,14-28,35-49,56,181 9.21.55.96.108.139.160.181 0-3,34,76,89,92,101,115,125 57-70,77-84,90,98,105,112,119,126-133, 140-154,161-175 181 0-49,74 54-70 74 0 70-74 70 70 70 14-74 7 70 74 74 CompanySanitized. Does notcontain toca cftt 648 H-24516: Subchronic Toxicity # 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation M VII 643158 General observation, No Abnormality Detected Removed from study M VII 643249 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Discharge, Nose, Black Diarrhea, Brown Stain Fur/Skin, Forepaw, Bilateral, Red Removed from study M VII 643161 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study M VII 643309 General observation. No Abnormality Detected General Teeth Observations, Clipped Breathing Observations, Labored Breathing Observations, Noise Discharge, Mouth, Red Discharge, Nose, Red Stain Fur/Skin, Forepaw, Bilateral, Red Stain Fur/Skin, Perineum, Yellow Accidentally Killed M VII 643248 General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Removed from study M VII 643285 General observation, No Abnormality Detected Abnormal Gait, Hindlimb, Left Swollen Observations, Hindlimb, Left Removed from study M VII 643278 General observation, No Abnormality Detected Discharge, Mouth, Clear Removed from study M VII 643299 General observation, No Abnormality Detected Removed from study M VII 643274 General observation. No Abnormality Detected Hyperreactive Removed from study ceiffpaRSarsixedLDees no contain TSCAOBI 649 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-63 70-74 70 70 70 70 74 0-63,74 '70 74 0-49 54-70 70 69 69-70 70 70 70 70 0-63,74 70 70 74 0-56,74 63-70 63-70 74 0-28,56-74 31-49 74 0-74 74 0-14,56-74 21-49 74 DuPont-5386 A H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation M VII 643192 General observation, No Abnormality Detected Comments, teeth loose General Teeth Observations, Broken General Teeth Observations, Clipped Comments, teeth loose Removed from study M VII 643222 General observation, No Abnormality Detected Removed from study M VII 643160 General observation. No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Removed from study M VII 643191 General observation. No Abnormality Detected Removed from study M VII 643203 General observation. No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Discharge, Mouth, Clear Removed from study M VII 643282 General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Removed from study M VII 643302 General observation, No Abnormality Detected General Teeth Observations, Clipped Discharge, Eye right, Red Stain Fur/Skin, Periocular, Bilateral, Black Removed from study M VII 643317 General observation. No Abnormality Detected Removed from study M VII 643225 General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 483 tfOSl iBuoacs&oq 'peziguss usdtogj 650 OBSERVATIONS AND MORTALITY DATA Days 0-63 67 70-74 70 67 74 0-74 74 0-63 74 70 74 0-74 74 0-28,56-70 74 74 34-49 74 0-63 70-74 70 74 0-63 74 70 74 74 0-74 74 0-49 54-77,84-119,125 80,122 125 % DuPont-5386 H90-2-D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation M VII 643296 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Diarrhea, Brown Stain Fur/Skin, Tail, Brown Stain Fur/Skin, Chin, Red Sacrificed by design M VII 643258 General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Comments, animal did not receive whole dose Stain Fur/Skin, Perineum, Red Sacrificed by design M VII 643316 General observation. No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design M VII 643220 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Right General Teeth Observations, Absent General Teeth Observations, Broken General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design M VII 643236 General observation. No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Broken General Teeth Observations, Clipped Discharge, Mouth, Clear No Ophthalmological Abnormalities Detected Sacrificed by design {>f;v tSi M VII 643165 General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Si Sacrificed by design o M VII 643266 General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected O' Sacrificed by design 9o 651 OBSERVATIONS AND MORTALITY DATA Days 0-63 70-77,84-90 98-119,125 80,122 70 119,125 70 125 0-35,42-63,84-119,125 80,122 41 70-77 125 0-77,84-105 112-119,125 80,122 125 0-28 35-77,84-119,125 63 70-77,84-119,125 63-77,84-119,125 80,122 125 0-21,35-56 63-70 70 63-77,84-119,125 28-34 80,122 125 0-70 76-77,84-90 87-119,125 80,122 125 0-70 77,84-119,125 80,122 125 % DuPont-5386 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal M VII 643151 M VII 643234 M VII 643281 Observation General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Left Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Broken General Teeth Observations, Clipped Aggressive Behavior Hyperreactive No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design General observation, No Abnormality Detected Removed from study, rat physically removed 2/24/01 Days 0-77,84-90 98-119,125 80,122 125 125 0 80-90 70-119,125 119,125 90-119,125 80,122 7-119,125 125 0-74 80 Sanitized. Does notcontain TSCACP' n oaaN 33 ;)30 *iiIt 652 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 643477 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91,93 45,92 93 80 93 F II 643374 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91,93 45,92-93 80 93 F II 643406 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F II 643486 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F II 643361 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F II 643463 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F II 643398 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45, 93 80 93 F II 643436 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F II 643362 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45, 93 80 93 # DuPont-5386 Ifa B u s a " M m u s |ea s o q p e ^ u s t o d a s o Q 653 1 H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F II 643354 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F II F II F II 643402 General observation. No Abnormality Detected Eye Observations, Closed, Left Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left Discharge, Nose, Black Hair Loss, Face, Left Sacrificed by design 643383 General observation, No Abnormality Detected Eye Observations, Bled via Orbital - Eye Observations, Bled via Orbital Eye Observations, Bled via Orbital Breathing Observations, Noise Discharge, Eye bilateral, Black Discharge, Eye bilateral, Brown Discharge, Nose, Black Discharge, Eye right, Black Discharge, Eye right, Brown Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right 643465 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Eye Observations, Bledvia Orbital Discharge, Eye bilateral, Black Discharge, Eye right, Black Hair Loss, Face, Right Sacrificed by design for Clin Path, Bilateral for Clin Path, Left for Clin Path, Right 0,7,14-28,35-49 175-181 112,119,126-133,140-154,161-168 77-84,91,98,105,112,119,126-133, 140-154,161-181 56-70 9,21 0-3,34,55,76,89,92-96,101,108,115,125, 139,160,181 70,77-84,91,98,105,112,119,126-133, 140-154,161-181 105 70 181 0,7,14-28,35-49,56-70,77-84,91, 147-154 55 9,21,96,108,160,181 0-3,34,76,89,92,101,115,125,139 140 98,105,112,119,126-133 161 98,105,112 140 168-181 181 0,7,14-28,35-49,56-70,77-84,91, 98,119,147-154,161-181 0 9,21,96,139,160,181 3,34,55,76,89,92,101,108,115,125 133,140 105,126 112 181 -a pD O 654 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation F II 643484 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Bled via Orbital for Clin Path, Eye Observations, Corneal Opacity, Bilateral Bilateral Left Right Eye Observations, Corneal Opacity, Breathing Observations, Noise Discharge, Eye bilateral, Black Discharge, Eye right. Black Sacrificed by design Left F II 643384 General observation, No Abnormality Detected F XI 643352 Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design General observation, No Abnormality Detected Removed from study F II F II 643343 643459 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study F II 643394 General observation, No Abnormality Detected Removed from study F II 643480 General observation, No Abnormality Detected Removed from study F II 643319 General observation. No Abnormality Detected Removed from study F II 643350 General observation, No Abnormality Detected Removed from study F II 643363 General observation, No Abnormality Detected Removed from study F II 643397 General observation. No Abnormality Detected Removed from study Days 0,7,14-21 35-49 3,9,21,34,55,76,160 96,139,181 0,89,92,101,108,115,125 35-49,56-70,77-84,91,98,105,112, 119,126-133,140-154,161-181 28 140-154,161-181 77 35-42,56 181 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,147-154,161-181 119,126-133,140 9,21,96,108,115,125,139,181 0-3,34,55,76,89,92,101,160 181 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 Santzed, Sees m i contain TSCCEI' 655 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F II 643421 General observation, No Abnormality Detected Removed from study F il 643420 General observation. No Abnormality Detected Removed from study F II 643419 General observation, No Abnormality Detected Removed from study F il 643414 General observation. No Abnormality Detected Removed from study F II 643401 General observation, No Abnormality Detected Removed from study F II 643455 General observation, NO Abnormality Detected Removed from study F II 643378 General observation, NO Abnormality Detected Removed from study F II 643393 General observation, NO Abnormality Detected Removed from study F II 643447 General observation, No Abnormality Detected Removed from study F II 643478 General observation, No Abnormality Detected Removed from study if F II 643386 General observation, No Abnormality Detected Removed from study -7 'ce" F II 643405 General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Hair Loss, Forelimb, Bilateral Hair Loss, Forelimb, Left Sacrificed by design so F II 643425 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643448 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Hair Loss, Forepaw, Bilateral Sacrificed by design 183 V9SJ. 656 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-21 60,122 28-77,84-112 119,125 125 0-77,84-119,125 80,122 125 0-56,112-119,125 80,122 63-77,84-105 125 DuPont-5386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F II 643426 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643415 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643453 General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643330 General observation. No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643336 General observation, No Abnormality Detected Discharge, Vulva, Red No Ophthalmological Abnormalities Detected Mass Perineum, Mass #1, Ulcerated, 1.0 cm Sacrificed in extremis F II 643387 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design F II 643377 General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design 657 OBSERVATIONS AND MORTALITY DATA Days 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-77,84-98 105 80 105 105 0-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 DuPont-5386 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F IV F IV 643390 643396 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, No Ophthalmological Abnormalities Detected Hair Loss, Side, Left Sacrificed by design Right 0-42,49-77,84-91,93 45,92-93 80 93 0-42,49-77 45,92-93 80 84-91,93 93 F IV 643380 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45, 93 80 93 F IV 643433 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F IV 643389 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Discharge, Eye right, Black No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-56 45,93 58-77,84-93 63-70 80 93 F IV 643410 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F IV 643321 General observation, No Abnormality Detected Abnormal Vocalization Convulsions, Clonic, went stiff Breathing Observations, Fast Prostrate Diarrhea, Brown Sacrificed in extremis 0-28 29 29 29 29 29 29 F IV 643324 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Hyperactive No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49 45,93 56-77,84-93 80 93 DuPont-5386 658 H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F IV 643458 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F IV 643364 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F IV 643483 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, .98,105,112,119,126-133,140-154,161-181 0-3 9,21,96,108,139,160,181 34,55,76,89,92,101,115,125 181 F IV F IV 643411 Eye Observations, Bled via Orbital for Clin Path, Right Comments, ak during bleed Accidentally killed 643379 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral ' Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Discharge, Eye right, Black Discharge, Eye right, Brown Sacrificed by design 0 0 0 0,7,14-28,35-49,56-70,77-84,91, 98,105,126,147-154,161-181 101,108,115,125 3,9,21,96,139,160,181 0,34,55,76,89,92 112,119 133,140 181 F IV 643391 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Nose Wound, Superficial, Nose Sacrificed by design 0,7,49,56-70,77-84,91,98,105,112,119, 126-133,140-154,161-181 3,9,21,96,108,139,160,181 0,34,55,76,89,92,101,115,125 21-28,35-42 14 181 F IV F IV 643437 643399 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design General observation, No Abnormality Detected Removed from study 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154,161-181 3,9,21,96,108,139,160,181 0,34,55,76,89,92,101,115,125 181 0-74 74 Sanitized. Does note''"*'* 659 it H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F XV F IV 643334 643464 General observation, No Abnormality Detected Removed from study General observation. No Abnormality Detected Removed from study F IV 643369 General observation, No Abnormality Detected Removed from study F IV 643490 General observation, No Abnormality Detected Removed from study F IV 643342 General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Hair Loss, Forepaw, Right Removed from study F IV F IV F IV 643438 643445 643418 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Comments, compound evident on mouth Removed from study General observation, No Abnormality Detected Removed from study F IV 643325 General observation, No Abnormality Detected Removed from study F IV 643479 General observation, No Abnormality Detected Removed from study F IV F IV 643403 643376 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study F IV F IV F IV 643422 643452 643475 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study SanHIzed. Does not contain TSCCBi 660 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-74 74 0-14 21-56 63-74 74 0-74 74 0-70,74 73 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Sex Group Animal F IV 643372 F IV 643400 F IV 643395 F IV 643457 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study Days 0-74 74 0-74 74 0-74 74 0-74 74 DuPont-5386 SHpaniSaRHfeed. Sees neSeerstenTSCCil 661 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 643322 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-91,93 45,92-93 80 93 F VI 643489 General observation, No Abnormality.Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F VI 643409 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 .45,93 80 93 F VI 643366 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F VI 643367 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77,84-93 45,93 80 93 F VI 643461 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Bilateral 0-42,49-77,84-93 93 p Eye Observations, Bled via Orbital for Clin Path, Right 45 1] (170,-07;, Retina, Retinal Degeneration Diffuse, Left Sacrificed by design 80 93 rrVvm.'/jOn w F VI 643462 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected 0-42,49-77,84-93 45,93 80 Kb Sacrificed by design 93 S' F VI 643392 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right 0-42,49-77,84-93 45,93 fi No Ophthalmological Abnormalities Detected 80 Sacrificed by design i 93 0 OHT-;iC 1 F VI 643472 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected 0-42,49-77,84-93 45,93 80 3 Sacrificed by design 93 r-4; m > a S 662 DuPont-5386 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________ DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal Observation Days F VI 643323 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Comments, protective gavage ball fell off predose Sacrificed by design 0-28,35-42,49-77,84-93 45,93 80 34 93 F VI 643412 General observation, No Abnormality Detected Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Sacrificed by design 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154,161-181 181 3,9,21,96,108,139,160 0,34,55,76,89,92,101,115,125 181 F VI F VI 643382 General observation, No Abnormality Detected Eye Observations, Partially Closed, Left Eye Observations, Enophthalmus, Left Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left . General Teeth Observations, Clipped Discharge, Eye left, Black Wound, Superficial, Mouth Sacrificed by design 643381 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Sacrificed by design 0,7,14-21 112.119.126-133,140-154,161-181 49,56-70,77-84,91,98,105,112,119, 126-133,140-154,161-181 28,35-42 3,9,21,115 0,34,55,76,89,92-96,101,108,125,139,160, 181 35-4 9,56-70,77-84,91,98,105, 112, 119.126- 133,140-154,161-181 126-133,140-154,161-181 28,35 63 181 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154,161-181 3,9,21,96,108,139,160,181 0,34,55,76,89,92,101,115,125 181 F VI 643360 General observation. No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Exophthalmus, Right Eye Observations, Bledvia Orbital for Clin Path, Bilateral Eye Observations, Bledvia Orbital for Clin Path, Left Eye Observations, Bledvia Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Discharge, Nose, Black Discharge, Eye left, Black Sacrificed by design 0,7,14-28,35-49,56-70,77-84 98,105,112,119,126 91 89,92,108,115 3,9,21,96,139,160,181 0,34,55,76,101,125 98,105,112,119,126-133,140-154,161-181 161-181 119 98,105,112 181 Company Sanded. Does no! cnota'n tsCCB 663 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Gneration Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal F VI 643373 Observation General observation, No Abnormality Detected Eye Observations, Exophthalmus, Bilateral Eye Observations, Exophthalmus, Left Eye Observations, Eye Observations, Eye Observations, Eye Observations, Eye Observations, Exophthalmus, Right Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Bled via Orbital for Clin Path, Corneal Opacity, Bilateral Bilateral Left Right Eye Observations, Corneal Opacity, Right Discharge, Eye right, Black Sacrificed by design F VI 643320 General observation, No Abnormality Detected Removed from study F VI F VI F VI F VI F VI 643488 General observation, No Abnormality Detected Removed from study 643428 General observation, No Abnormality Detected Removed from study 643439 General observation, No Abnormality Detected Removed from study 643353 General observation, No Abnormality Detected Removed from study 643385 General observation, No Abnormality Detected Removed from study F VI F VI 643339 643473 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study F VI 643337 General observation, No Abnormality Detected Removed from study F VI 643416 General observation, No Abnormality Detected Removed from study F VI 643407 General observation, No Abnormality Detected Hair Loss, Forelimb, Right Comments, compound evident on lips Removed from study Days 0,7,14-28 56-70 77-84,91,98,105,112,119,126-133, 140-154,161-181 35-49 0,55,76,89,92,108,115 3,9,21,96,139 34,101,125,160,181 56-70,77-84,91,98,105,112,119,126-133, 140-154,161-181 35-49 35 181 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-74 74 0-28,36 664 #* H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 Sex Group Animal F VI 643357 F VI- 643331 F VI 643427 F VI 643470 F VI 643434 F VI 643349 F VI F VI F VI 643454 643333 643460 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study 0-74 74 0-74 74 General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Hair Loss, Forepaw, Bilateral Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study General observation, No Abnormality Detected Removed from study- 0-74 74 0-74 74 0-21,74 28-70 74 0-74 74 0-74 74 0-74 l i s ^ 3 S i ujgjusa JM m-Q'pez]j|y8g 665 0' 0 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Sex Group Animal P VIII 643341 F Vili 643370 F Vili 643446 F Vili 643435 F Vili 643466 F Vili 643332 F Vili 643404 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-70 45,92-93 76-77,84-91,93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-63 45,93 65-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-56 45,93 63-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped Hyperactive Hyperreactive No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-63 45, 93 84-93 70-77,84-93 70-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-77 45,93 84-93 80 93 General observation. No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design 0-42,49-56 45, 93 63-77,84-93 80 93 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Right 0-42,49-77 45,93 84-93 80 93 DuPont-5386 CompanySanitized. Does not eonta'n TSCCBI 666 H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations DuPont-5386 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal F VIII 643408 Observation General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 643359 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 643340 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Right Hair Loss, Forepaw, Bilateral Found dead in cage. F VIII 643487 General observation, No Abnormality Detected Eye Observations, Exophthalmus, Right Eye Observations, Bled via Orbital for Clin Path, Bilateral Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Right General Teeth Observations, Clipped Sacrificed by design F Vili 643356 General observation, No Abnormality Detected Observations, Partially Closed, Left iye Observations, Enophthalmus, Bilateral 5ye Observations, Exophthalmus, Left ye Observations, Exophthalmus, Right 5ye Observations, Bled via Orbital for Clin Path, Bilateral Sye Observations, Bled via Orbital for Clin Path, Left ve Observations. Bled via Orbital for Clin Path, Right Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Breathing Observations, Noise Discharge, Eye left. Black Discharge, Eye right. Black Hair Loss, Face, Right Comments, compound evident on mouth Sacrificed by design Days 0-42,49-63 45,93 70-77,84-93 80 93 0-42,49-77,84-93 45,93 80 93 0-14 45 21-42,49-69 69 0,7,14-28,35-49,56-70 77-84 76,89,92 3,9,21,96,108,139,160,181 0,34,55,101,115,125 77-84,91,98,105,112,119,126-133, 140-154,161-181 80,119,126-133,140-154,161-181 181 0,7,14-28 112.119.126- 133,140-154,161-175 181 35-49 161-175 21,34 3,9 0,55,76,89,92-96,101,108,115,125,139,160, 181 35-49,56-84,91,98,105, 112 105.112.119.126- 133,140-154,161-181 140-154,161-175 35,98,105,112,119 161-175 49 76 181 Company Sanitized. Does not contain TSCAC: I 667  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations Sex Group Animal F VIII 643329 F VIII 643368 F VIII 643450 p VIII 643467 F VIII 643443 F VIII 643417 F VIII 643413 F VIII 643338 INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Observation Days General observation. No Abnormality Detected Eye Observations, Bled viaOrbital for Clin Path, Bilateral Eye Observations, Bled viaOrbital for Clin Path, Left Eye Observations, Bled viaOrbital for Clin Path, Right General Teeth Observations, Clipped Hair Loss, Neck, Dorsal Hair Loss, Nose Sacrificed by design 0,7,42-49,56-70,77-84,91,98 101 3,9,21,96,108,139,160,181 0,34,55,76,89,92,115,125 105.112.119.126-133,140-154,161-181 14-28,35 14.119.126- 133 181 General observation, No Abnormality Detected Eye Observations, Bled via Orbital for Clin Path, Left Eye Observations, Bled via Orbital for Clin Path, Right General Teeth Observations, Clipped Sacrificed by design 0,7,14-28,35-49 3,9,21,96,108,139,160,181 0,34,55,76,89,92,101,115,125 54,56-70,77-84,91,98,105,112,119, 126-133,140-154,161-181 181 General observation. No Abnormality Detected Eye Observations, Exophthalmus, Left Eye Observations, Bled via Orbital for Clin Eye Observations, Bled via Orbital for Clin Eye Observations, Bled via Orbital for Clin Eye Observations, Corneal Opacity, Left General Teeth Observations, Clipped Discharge, Eye left, Black Comments, growth on left eye Sacrificed by design Path, Bilateral Path, Left Path, Right 0,7,14-28,35-49,56-70,77-84,91, 98,105,112,119,126-133,140-154 161-181 108,115 3,9,21,96,139,160 0,34,55,76,89,92,101,125,181 168-181 161-181 161 181 181 General observation, No Abnormality Detected General Teeth Observations, Clipped Hair Loss, Hindlimb, Left Hair Loss, Side, Right Removed from study 0-63 70 74 74 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study 0-63,74 70 74 General observation, No Abnormality Detected Removed from study 0-74 74 General observation, No Abnormality Detected Removed from study 0-74 74 DuPont-5386 CompanySanitized. Bees notcontain TSCACB1 668 ## -24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F VIII 643335 General observation. No Abnormality Detected Removed from study F VIII 643468 General observation, No Abnormality Detected General Teeth Observations, Clipped Discharge, Nose, Red Diarrhea, Black Stain Fur/Skin, Face, Brown Removed from study F VIII 643440 General observation, No Abnormality Detected General Teeth Observations, Clipped Stain Fur/Skin, Inguen, Yellow Stain Fur/Skin, Face, Brown Removed from study F VIII 643430 General observation, No Abnormality Detected Comments, teeth loose General Teeth Observations, Absent General Teeth Observations, Broken Removed from study F VIII 643431 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study F VIII 643368 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Bilateral Discharge, Mouth, Tan Dehydrated. Stain Fur/Skin, Perineum, Yellow Wet Fur, Perineum Accidentally Killed F VIII 643326 General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped Discharge, Eye bilateral, Black Discharge, Mouth, Clear Removed from study F VIII 643365 General observation, No Abnormality Detected Removed from study F VIII 643375 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study Sanlized. Does no contain TSCACB! 669 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-63,74 70 70 70 70 74 0-56,74 63-70 70 63-70 74 0-70 71 71-74 71-74 74 0-63 70-74 74 0-42 49-53 47-53 47-53 47-53 47-53 53 0-56,74 63-70 63-70 63 63 74 0-74 74 0-70 74 74 DuPont-5386 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL Sex Group Animal Observation F VIII 643328 General observation, No Abnormality Detected Removed from study F VIII 643348 General observation, No Abnormality Detected Removed from study F VIII 643346 General observation, No Abnormality Detected Removed from study F VIII 643449 General observation, No Abnormality Detected General Teeth Observations, Clipped Removed from study F VIII 643429 General observation, No Abnormality Detected General Teeth Observations, Clipped Hair Loss, Forelimb, Bilateral Hair Loss, Hindlimb, Bilateral Hair Loss, Hindlimb, Right Hair Loss, Side, Bilateral Hair Loss, Side, Right Removed from study F VIII 643424 General observation, No Abnormality Detected General Teeth Observations, Clipped - Removed from study F VIII 643347 General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 643456 General observation, No Abnormality Detected General Teeth Observations, Maloccluded General Teeth Observations, Clipped Discharge, Eye right. Red No Ophthalmological Abnormalities Detected Sacrificed by design F VIII 643423 General observation, No Abnormality Detected Eye Observations, Enophthalmus, Right General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Mass Abdomen, Mass #2, Not Ulcerated, 1.0 cm Mass Side, Left, Mass #1, Not Ulcerated, 1.5 cm Mass Side, Left, Mass #1, Not Ulcerated, 1 cm. Sacrificed by design 670 OBSERVATIONS AND MORTALITY DATA Days 0-74 74 0-74 74 0-74 74 0-56,74 63- 70 74 0-28 70 42-74 42-74 35 56-74 49 74 0-70 74 74 0-77,84-112 119.125 80,122 125 0-49 119.125 54-77,84-119,125 119.125 80,122 125 0-14 21-77,84-119,125 84-119,125 80,122 119.125 112-119,125 64- 77,84-105 125 % DuPont-5386 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproduction Evaluations INDIVIDUAL CLINICAL AND OPHTHALMOLOGICAL OBSERVATIONS AND MORTALITY DATA Sex Group Animal F VIII 643345 F VIII 643351 F VIII 643358 F VIII 643444 iF VIII 643474 F VIII 643441 F VIII 643481 Observation General observation. No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Absent General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Clipped General Teeth Observations, Clipped, teeth caught in cage No Ophthalmological Abnormalities Detected Stain Fur/Skin, Shoulder, Right, Brown Sacrificed by design General observation, No Abnormality Detected .No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design General observation, No Abnormality Detected General Teeth Observations, Clipped No Ophthalmological Abnormalities Detected Sacrificed by design Days 0-49 54-77,84-119,125 80,122 125 0-56 63-65 65-77,84-119,125 80,122 125 0-77,84-119,125 80,122 125 0-14 105-119,125 73 80,122 21-77,84-112 125 0-77,84-119,125 80,122 125 0-56 63-77,84-119,125 80,122 125 0-77,84-98 105-119,125 80,122 125 DuPont-5386 IS O V O S I UiBuoo JO 671 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX F OPHTHALMOLOGY EXAMINATION REPORTS 672 ftesi ii-ATjiu. ouL/cuiuiuc ioxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLOG(TIECSATLDEAXYAM80I)NATION REPORT DuPont-5386 NAN<EC1YY1BE9MEMCT.LABHIRSENSOSIACDMCAFBH,OEMURRSDEGATN,2VT0IM8SJ1tAf6JVL>ES.,MJS. STUDYINFORMATION: SSSttpuuedddyyDN:ioRreacttor:GregLadira 1 OPHTHALMOExLaOmGinIaCtAioLnDEXatAe:MMINarAchTI2O,2N00S1UMMARY SMexETHODS: IGnrdoiurepc#tOphthCaalmgeo#scopyfoAllonwiminagl#1%TrOobpsicearmvaitdioenmydriasis 60186 606 643461 DiffuseretinaldegenerationOS COMMENTS/DISCUSSION ooprhhitthaalmoascopic^lesiBonn.'"sd.eenvNtro`fbcr^ot"m'^pounrdebtirtneeaelalddtienedg8e-anb^enraotroimothnawwlithieicshwmeraeyeibxdaeemndtniinfeieetddo.htraadunmoavtiosibthlee 673 @mpany Sanitized. Does not contain TSCA CBI n-/4Dio: subcromc Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations OPHTHALMOLO(GTIECSATLDEAXYA1M22IN) ATION REPORT DuPont-5386 NANCYM6.E1BY1RBE9OEMCTMLAHBISENESSIARCDCGAFH,O,VUMR.SMDEA.TDN2T0.I,M8SM1AA6.SVL.SE, DA.C.V.O. STUDYINFORMATION: SSStptuueddciyyesDN:oiKr|eicttor: ) GregLadics OPHTHALMEOxLaOmGinIaCtAioLnEDXatAe:MAIpNrAilT1I3O,2N00S1UMMARY METHODS: Indirect Ophthalmoscopyfollowing1%Tropicamidemydriasis COMMAEllNaTniSm/DaIlsSCexUaSmSiInOedNhadnovisibleophthalmoscopiclesions. 674 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations m DuPont-5386 APPENDIX G INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH 675 Sesnpany Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group I 0 mg/kg/day NAunmimbaelr 643162 643172 643195 643226 643237 643246 643253 643262 643303 ' 643304 Forelimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.52 0.51 0.59 0.54 0.51 0.83 0.55 0.63 0.60 0.57 0.35 0.51 0.56 0.65 0.60 0.60 0.36 0.29 0.48 0.38 0.39 0.48 0.48 0.45 0.52 0.48 0.58 0.53 0.52 0.60 0.59 0.57 0.49 0.56 0.51 0.52 0.40 0.44 0.38 0.41 Hindlimb Grip Strength Ike-) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.45 0.37 0.43 0.42 0.31 0.39 0.45 0.38 0.40 0.38 0.42 0.40 0.36 0.39 0.28 0.34 0.58 0.34 0.51 0.32 0.53 0.30 0.48 0.38 0.34 0.39 0.52 0.42 0.51 0.47 0.59 0.52 0.37 0.39 0.33 0.36 0.23 0.43 0.30 0.32 DuPont-5386 676 Company Sanitized. Does not contain TSCA CB1 # #H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group III 25 mg/kg/day NAunmimbaelr 643173 643179 Forelimb GriioStreneth fkel Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.60 0.53 0.43 0.52000 0.42 0.33 0.64 0.46333 643180 643228 643240 643264 643272 643290 643292 ' 643308 0.45 0.48 0.56 0.49667 0.83 0.77 0.72 0.77333 0.52 0.46 0.67 0.55000 0.59 0.66 0.41 0.55333 0.38 0.36 0.55 0.43000 0.31 0.60 0.45 0.45333 0.50 0.63 0.63 0.58667 0.46 0.38 0.39 0.41000 Hindlimb Grin Strength (kg') Trial Trial 2 Trial 3 ThMreeeanTroiafls 0.48 0.42 0.42 0.44000 0.43 0.40 0.50 0.44333 0.37 0.47 0.56 0.46667 0.27 0.26 0.39 0.30667 0.27 0.26 0.24 0.25667 0.32 0.39 0.37 0.36000 0.37 0.42 0.39 0.39333 0.40 0.39 0.45 0.41333 0.31 0.30 0.31 0.30667 0.59 0.38 0.33 0.43333 DuPont-5386 677 Company Sanitized. Does not contain TSCA CB1 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group V 100 mg/kg/day NAunmimbaelr 643175 643224 643243 643247 643250 643257 643275 643311 643314 ' 643318 Forelimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.50 0.65 0.41 0.52 0.57 0.42 0.44 0.48 0.47 0.37 0.37 0.40 0.71 0.50 0.80 0.67 0.64 0.51 0.46 0.54 0.56 0.48 0.48 0.51 0.59 0.70 0.54 0.61 0.74 0.47 0.55 0.59 0.64 0.60 0.56 0.60 0.53 0.41 0.38 0.44 Hindlimb Grin Strength (kg! Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.43 0.30 0.35 0.36 0.23 0.47 0.28 0.33 0.32 0.39 0.30 0.34 0.26 0.29 0.39 0.31 0.32 0.26 0.39 0.32 0.38 0.32 0.43 0.38 0.42 0.32 0.40 0.38 0.30 0.37 0.35 0.34 0.37 0.43 0.46 0.42 0.35 0.45 0.32 0.37 DuPont-5386 678 Company Sanitized. Does nun cuaia>n TSCA CB1 0 H-24516: Subchronic Toxicity .^^j^j^Gawjgcjtudyrin with One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Male Rats/Group VII 250 mg/kg/day NAunmimbaelr 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 Forelimb Grip, Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.66 0.55 0.76 0.66 0.48 0.54 0.46 0.50 0.70 0.67 0.53 0.63 0.56 0.46 0.56 0.53 0.60 0.47 0.54 0.54 0.54 0.48 0.51 0.51 0.53 0.58 0.46 0.52 0.33 0.38 0.44 0.38 0.66 0.76 0.61 0.68 0.56 0.46 0.46 0.49 Hindlimh Grin Strength fkgl Trial 1 Trial 2 0.49 0.31 Trial 3 0.46 ThMreeeaTnroiafls 0.42 0.33 0.34 0.30 0.32 0.50 0.40 0.29 0.43 0.33 0.43 0.27 0.66 0.34 0.39 0.46 0.37 0.31 0.38 0.60 0.49 0.30 0.43 0.43 0.41 0.36 0.44 0.44 0.41 0.59 0.41 0.26 0.27 0.45 0.38 0.48 0.30 # DuPont-5386 679 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group II 0 mg/kg/day NAunmimbaelr 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Forelimb Grip Strength CkeD Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.28 0.71 0.57 0.52 0.60 0.46 0.45 0.50 0.47 0.77 0.67 0.64 0.51 0.62 0.88 0.67 0.51 0.76 0.55 0.61 0.54 0.68 0.55 0.59 0.47 0.47 0.61 0.52 0.37 0.47 0.54 0.46 0.59 0.80 0.61 0.67 0.62 0.76 0.63 0.67 Hindlimb Grin Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.42 0.33 0.32 0.36 0.34 0.43 0.53 0.43 0.45 0.42 0.37 0.41 0.38 0.41 0.37 0.39 0.27 0.32 0.23 0.27 0.31 0.48 0.30 0.36 0.37 0.40 0.38 0.38 0.38 0.40 0.35 0.38 0.41 0.41 0.31 0.38 0.34 0.34 0.41 0.36 # DuPont-5386 680 Company Sanitized. Does not contain TSCA CBI # #H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group IV 25 mg/kg/day NAunmimbaelr 643321 643324 643364 643380 643389 643390 643396 643410 643433 ' 643458 Forelimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.74 0.60 0.51 0.62 0.46 0.63 0.56 0.55 0.37 0.40 0.53 0.43 0.43 0.56 0.56 0.52 0.43 0.31 0.43 0.39 0.74 0.76 0.73 0.74 0.47 0.66 0.72 0.62 0.33 0.30 0.50 0.38 0.42 0.65 0.47 0.51 0.62 0.74 0.56 0.64 Hindlimb Grip Strength fleet Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.35 0.38 0.26 0.33 0.33 0.40 0.38 0.37 0.44 0.43 0.50 0.46 0.44 0.61 0.43 0.49 0.35 0.39 0.30 0.35 0.57 0.37 0.37 0.44 0.34 0.45 0.36 0.38 0.33 0.32 0.27 0.31 0.44 0.35 0.40 0.40 0.39 0.29 0.35 0.34 # DuPont-5386 681 Company Sanitized. Does not contain TSCACBt H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group VI 100 mg/kg/day Forelimb Grin Strength (kg') NAunmimbaelr 643322 643323 643366 643367 643392 Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.59 0.65 0.79 0.68 0.31 0.43 0.52 0.42 0.80 0.70 0.68 0.73 0.30 0.38 0.28 0.32 0.48 0.37 0.62 0.49 643409 643461 643462 643472 ' 643489 0.51 0.61 0.77 0.61 0.44 0.40 0.36 0.63 0.71 0.50 0.42 0.51 0.56 0.55 0.60 0.63 0.48 0.57 0.48 0.57 Hindlimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.43 0.41 0.30 0.38 0.29 . 0.32 0.30 0.30 0.49 0.36 0.42 0.42 0.34 0.27 0.35 0.32 0.41 0.32 0.27 0.33 0.36 0.30 0.31 0.32 0.35 0.36 0.27 0.33 0.32 0.30 0.41 0.34 0.33 0.37 0.36 0.35 0.49 0.50 0.37 0.45 DuPont-5386 682 Company Sanitized. Does not contain TSCA CBt  H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Baseline Female Rats/Group VIII 250 mg/kg/day Forelimb Grip Strength (kg) NAunmimbaelr 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.39 0.56 0.60 0.52 0.76 0.86 0.77 0.80 0.87 0.77 0.76 0.80 0.56 0.41 0.56 0.51 0.33 0.48 0.37 0.39 0.66 0.42 0.43 0.50 0.57 0.67 0.53 0.59 0.59 0.77 0.88 0.75 0.45 0.52 0.46 0.48 0.56 0.86 0.42 0.61 Hindlimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.28 0.40 0.35 0.34 0.45 0.51 0.27: 0.41 0.26 0.36 0.39 0.34 0.42 0.34 0.31 0.36 0.33 0.36 0.41 0.37 0.30 0.37 0.37 0.35 0.44 0.32 0.41 0.39 0.29 0.25 0.31 0.28 0.34 0.41 0.37 0.37 0.30 0.35 0.38 0.34 DuPont-5386 683 Company Sanitized. Does not contain TSCA CBI  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group I 0 mg/kg/day Forelimb Grip Strength (kel NAunmimbaelr 643162 643172 Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 1.44 0.99 0.99 1.14 1.39 1.73 1.63 1.58 643195 643226 643237 643246 643253 643262 643303 ' 643304 1.60 1.18 1.51 2.29 1.33 1.64 0.87 1.05 0.94 0.80 0.96 0.69 1.48 1.46 2.10 1.43 2.32 1.20 1.65 1.69 1.59 0.84 1.54 1.17 1.43 1.75 0.95 0.82 1.68 1.65 1.64 1.18 Hindlimb Grip Strength flee! Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.89 0.71 0.86 0.82 1.01 0.65 0.78 0.81 0.95 0.80 0.98 0.91 0.90 1.01 0.90 0.94 0.61 0.85 0.83 0.76 0.69 0.59 0.51 0.60 0.83 1.14 0.87 0.95 1.04 1.20 0.91 1.05 1.04 0.96 0.80 0.93 0.63 0.61 0.62 0.62 # DuPont-5386 684 .Company Sanitized. Does not contain TSCA CB1  H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group III 25 mg/kg/day Forelimb Grin Strength (kg~) NAunmimbaelr 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 1.98 1.44 1.78 1.73 0.64 1.01 1.09 0.91 1.49 1.64 1.28 1.47 1.76 1.92 1.14 1.61 1.60 1.35 1.03 1.33 0.74 1.48 0.97 1.06 1.50 1.05 1.01 1.19 1.35 0.92 1.24 1.17 1.15 1.12 1.40 1.22 1.54 2.09 1.72 1.78 Hindlimb Grip Strength flcel Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.68 0.78 0.68 0.71 1.00 0.95 0.79 0.91 0.71 0.71 0.86 0.76 0.94 0.67 0.86 0.82 0.70 0.75 0.82 0.76 0.90 0.75 0.77 0.81 0.80 0.61 0.70 0.70 0.88 0.69 0.97 0.85 0.74 0.97 0.93 0.88 0.99 0.69 0.82 0.83 DuPont-5386 685 Company Sanitized. Does not contain TSCA CB4 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group V 100 mg/kg/day NAunmimbaelr Forelimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 643175 a 643224 1.24 0.70 0.57 643243 0.76 1.03 1.25 643247 1.43 1.48 1.18 643250 1.64 1.54 1.98 643257 1.33 1.49 1.03 643275 1.99 0.92 1.05 643311 1.64 1.95 0.82 643314 ' 1.99 1.73 1.81 643318 1.77 1.43 1.39 ... 0.84 1.01 1.36 1.72 1.28 1.32 1.47 1.84 . 1.53 Hindlimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.67 0.80 0.66 0.80 0.75 0.61 0.76 0.97 0.87 0.87 1.07 1.29 0.63 1.17 0.63 0.77 0.76 0.95 0.67 0.51 0.65 0.77 0.81 0.76 0.74 0.74 0.89 0.71 0.72 0.87 1.08 0.81 0.83 0.61 0.78 0.79 DuPont-5386 "Sacrificed inextremisprior to evaluation. 686 Company Sanitized. Does not contain TSCACflf #0 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Male Rats/Group VII 250 mg/kg/day NAunmimbaelr 643151 643165 643220 643225 643234 643236 643258 643266 643296' 643316 Forelimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 1.32 1.31 1.33 1.32 0.75 1.62 1.59 1.32 1.15 1.01 0.63 0.93 1.73 1.63 1.86 1.74 1.42 1.34 1.25 1.34 1.54 1.22 1.03 1.26 0.91 1.65 1.21 1.26 0.98 1.00 1.04 1.01 1.49 . 1.33 1.85 1.56 1.58 1,22 1.21 1.34 Hindlimb Grin Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.56 0.74 0.81 0.70 0.56 0.61 0.50 0.56 0.84 0.70 0.76 0.77 0.70 0.70 0.76 0.72 0.61 0.78 0.78 0.72 0.61 0.74 0.65 0.67 0.69 0.92 1.10 0.90 0.71 0.53 0.61 0.62 0.97 0.77 0.73 0.85 0.99 0.74 0.82 0.86 # DuPont-5386 687 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group II 0 mg/kg/day NAunmimbaelr 643330 643336 643377 643387 643405 643415 643425 643426 643448 ' 643453 Forelimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.93 1.00 0.94 0.96 1.12 1.37 1.27 1.25 1.16 1.63 1.45 1.41 1.17 0.69 0.96 0.94 1.05 1.31 1.19 1.18 1.13 0.97 0.64 0.91 1.42 1.23 1.20 1.28 1.10 0.90 1.05 1.02 1.16 1.41 0.92 1.16 1.84 1.48 1.80 1.71 Hindlimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.66 0.91 0.85 0.81 0.55 0.66 0.50 0.57 0.58 0.91 0.86 0.78 0.88 0.74 0.80 0.81 0.58 0.53 0.74 0.62 0.77 0.65 0.69 0.70 0.62 0.62 0.63 0.62 0.82 0.92 0.80 0.85 0.80 0.83 0.74 0.79 0.69 0.79 0.85 0.78 # DuPont-5386 688 Company Sanitized. Does not contain TSCA CStf ## H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________ # DuPont-5386 INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group IV 25 mg/kg/day NAunmimbaelr 643321 a 643324 643364 643380 643389 643390 643396 643410 643433 ' 643458 Forelimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.77 0.95 1.07 0.71 0.57 1.39 1.45 1.44 0.90 1.27 1.13 1.36 1.64 1.68 1.21 1.25 1.17 1.05 1.58 1.48 1.12 1.12 1.10 1.15 1.13 1.61 1.53 0.93 0.89 1.26 1.25 1.51 1.16 1.39 1.12 1.42 Hindlimb Grip Strength Ikel Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.59 0.45 0.53 0.71 0.74 0.71 0.62 0.70 0.76 0.73 0.82 0.67 0.73 0.79 0.81 0.85 1.10 0.81 0.71 0.90 0.81 0.50 0.61 0.56 0.72 0.69 0.76 0.52 0.72 0.69 0.74 0.78 0.92 0.81 0.56 0.72 Sacrificed inextremisprior to evaluation. 689 Company Sanitized. Does not contain TSCA CBI 00 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group VI 100 mg/kg/day Forelimb Grip Strength (kg') NAunmimbaelr 643322 643323 643366 643367 643392 643409 643461 643462 643472 ' 643489 Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.74 0.52 0.53 0.60 1.12 0.93 0.64 0.90 1.00 1.62 1.22 1.28 1.19 0.95 0.74 0.96 0.87 1.06 0.75 0.89 1.05 1.31 1.56 1.31 1.02 1.23 1.38 1.21 0.72 1.11 1.50 1.11 1.02 1.36 0.90 1.09 1.05 1.18 0.80 1.01 Hindlimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.42 0.57 0.46 0.48 0.56 0.59 0.62 0.59 0.75 0.77 0.81 0.78 0.69 0.69 0.56 0.65 0.45 0.69 0.59 0.58 0.50 0.51 0.71 0.57 0.62 0.80 0.67 0.70 0.75 0.81 0.82 0.79 0.55 0.81 0.50 0.62 0.70 0.70 0.71 0.70 # DuPont-5386 690 Company Sanitized. Does not contain TSC CBI # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Week 13 Female Rats/Group VIII 250 mg/kg/day NAunmimbaelr 643345 643347 643351 643358 643423 643441 643444 643456 643474' 643481 Forelimb Grip Strength Ike) Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.77 0.65 0.56 0.66 0.84 0.91 0.66 0.80 0.66 1.22 0.77 0.88 0.88 0.89 0.65 0.81 1.08 1.00 1.27 1.12 0.90 1.53 0.89 1.11 1.02 1.58 1.34 1.31 0.77 0.94 0.99 0.90 1.21 1.33 1.02 1.19 1.37 1.46 1.01 1.28 Hindlimb Grip Strength (ke) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.75 0.66 0.59 0.67 0.64 0.54 0.71 0.63 0.69 0.51 0.57 0.59 0.67 0.45 0.53 0.55 0.58 0.67 0.64 0.63 0.66 0.71 0.71 0.69 0.84 0.88 0.92 0.88 0.34 0.35 0.36 0.35 0.54 0.72 0.67 0.64 0.98 0.75 0.63 0.79 DuPont-5386 691 ante!. D0S * cofflaimsCA CBl Company # H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Male Rats/Group I 0 mg/kg/day Forelimb Grip Strength (kg-) NAunmimbaelr 643162 643172 643195 643226 643237 643246 643253 643262 643303 ' 643304 Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 1.09 0.78 1.30 1.06 1.26 1.37 1.66 1.43 1.42 1.16 1.67 1.42 1.31 0.82 1.51 1.21 0.69 0.73 0.79 0.74 0.99 0.76 0.81 0.85 1.10 1.22 1.34 1.22 1.83 1.86 1.21 1.63 1.16 1.62 2.08 1.62 1.89 1.04 1.56 1.50 Hindlimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.74 0.65 0.62 0.67 0.65 0.92 0.78 0.78 0.61 0.76 0.76 0.71 0.64 0.58 0.61 0.61 0.64 0.61 0.65 0.63 0.66 0.77 0.62 0.68 1.47 0.76 1.05 1.09 0.72 1.01 0.81 0.85 0.70 0.70 0.58 0.66 0.67 0.71 0.76 0.71 DuPont-5386 692 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Male Rats/Group VII 250 mg/kg/day NAunmimbaelr 643151 643165 643220 643225 643234 643236 643258 643266 643296 ' 643316 Forelimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 1.34 0.80 1.30 1.15 2.05 1.85 1.45 1.78 0.75 0.62 0.73 0.70 0.91 0.94 1.22 1.02 1.58 0.60 0.55 0.91 0.81 0.93 0.75 0.83 0.99 1.01 0.86 0.95 1.21 0.89 0.77 0.96 1.14 1.27 1.55 1.32 0.86 0.70 0.55 0.70 Hindlimb Grip Strength (kel Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.71 0.52 0.66 0.75 0.59 0.61 0.61 0.67 0.90 0.82 0.86 0.86 0.89 0.80 0.76 0.82 0.65 0.64 0.63 0.64 0.85 0.87 0.74 0.82 0.63 0.63 0.71 0.66 0.84 0.87 0.59 0.77 0.97 0.80 0.80 0.86 0.77 0.71 0.86 0.78 DuPont-5386 693 Company Sanitized. Does not contain TSCA CBl # H-24516: Subchronic Toxicity Rats with One-Generation Reproductive Evaluations INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Female Rats/Group II 0 mg/kg/day NAunmimbaelr 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 a Forelimb Grip Strength (kg) Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.65 0.64 0.55 0.61 0.93 0.86 0.98 1.27 1.43 1.19 0.98 0.94 1.01 1.11 1.63 1.61 1.15 1.51 1.34 0.93 1.21 1.16 0.83 0.75 0.73 1.15 0.97 1.35 0.92 1.30 0.98 1.45 1.33 1.10 0.77 1.16 Hindlimh Grin Strength CkPt Trial 1 Trial 2 0.46 0.58 Trial 3 0.54 ThMreeeanTroiafls 0.53 0.76 0.67 0.78 0.80 0.72 0.76 0.55 0.59 0.63 0.73 0.73 0.61 0.65 0.67 0.70 0.82 0.90 0.79 0.59 0.73 0.58 0.93 0.59 0.69 0.74 0.76 0.59 0.67 0.69 0.84 0.63 0.74 # DuPont-5386 Sacrificed inextremisprior to evaluation. 694 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________________________ INDIVIDUAL FORELIMB GRIP STRENGTH AND HINDLIMB GRIP STRENGTH Recovery Female Rats/Group VIII 250 mg/kg/day NAunmimbaelr 643345 643347 643351 643358 643423 643441 643444 643456 643474. ' 643481 Forelimb Grip Strength (kel Trial 1 Trial 2 Trial 3 ThMreeeanTroiafls 0.86 0.72 0.89 0.82 0.65 0.71 0.94 0.77 1.56 1.38 0.93 1.29 0.93 1.30 1.16 1.13 0.73 1.30 0.64 0.89 1.49 1.83 1.68 1.67 1.83 1.46 1.64 1.64 0.86 0.71 1.08 0.88 0.66 0.76 1.12 0.85 1.35 1.73 1.11 1.40 Hindlimb Grip Strength (kg') Trial 1 Trial 2 Trial 3 ThMreeeaTnroiafls 0.68 0.72 0.72 0.71 0.64 0.50 0.57 0.57 0.57 0.62 0.54 0.58 0.53 0.66 0.68 0.62 0.68 0.79 0.89 0.79 0.66 0.75 0.71 0.71 0.79 0.78 0.81 0.79 0.61 0.55 0.53 0.56 0.48 0.56 0.46 0.50 0.70 0.75 0.87 0.77 DuPont-5386 695 Company Sanitized. Does not contain TSCA C Bf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX H INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT 696 ompany Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY SCORING SYSTEM APPROACH & TOUCH: AUDITORY STIMULUS: TAIL PINCH: DEFECATION: URINATION: PUPILLARY RESPONSE: MANIPULATIONS INOPENFIELDARENA(TREE ROAMINGSPACE! -101 === nninoocrrmreeaaaslcetidorneaction (jumps awayor attacks) -101 === ennxooarmrgegaaeclrtraieotaencdtrioeanc(triaotnf(lirnacthjuems oprs,flfilcipkss)ear) -101 === nenxooarmrgegaseplro(atntuesrdenrsetsopwoanrsdes(ivteo)calizations, rapidturning) IN MOTOR ACTIVITY MONITOR D01 === pdabriaesrserenhnteta 01 == pabresseenntt 01 == pabresseenntt 697 Sanitized. Does not contain TSCA C ttf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group I: 0 mg/kg/day MANIPULATIONS IN MA MONITOR 643162 Baseline Week 13 X uSC tz> < 9tu ohQ O OJ H 2< hCO U5OJ3Xu H 0r2i a53Hd,, ooZcOe^ouosi OZ UbwQ<wi .,n 1sySKiw ,o.. 0 ( S WSXtSgflKm' T 0 00 O2 H< '.i'mF0i* Recovery 000 0 10 643172 Baseline Week 13 I I M i IMSIIBB M P M 000 0 1 0 S- S P -1K!_n Recovery 000 0 10 643195 Baseline Week 13 IBilM H U M < -- 000 0 0 0 Bi Recovery 000 01i 643226 Baseline Week 13 Slii laliSi0ii 0 SiH l i l B i g 0 l l l 00 000 Recovery 000 01i 643237 Baseline Week 13 ,0- b I8MMM 000 H 0 ttS1i B0 Recovery 000 011 643246 Baseline Week 13 M im iiW a 0 imiM 0 M 0 lI M M0M l' 1 i 0 Recovery 000 000 643253 Baseline iWBSBIlMPiWBBMIliaim i H i g i i g i 1 i! Week 13 000 000 Recovery 000 011 ` 643262 Baseline i g p B I M M j l l l l | | j Week 13 000 M itM P If 000 Recovery 000 00 i 643303 Baseline Week 13 WBSB&0 0 I1HMM8 0 0. i 000 Recovery 0 .0 011 643304 Baseline M I W 0 W B B B i 1 -'C m Week 13 000 01i Recovery 000 01i 698 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group DI: 25 mg/kg/day 643173 Baseline Week 13 643179 Baseline Week 13 643180 Baseline Week 13 643228 Baseline Week 13 643240 Baseline Week 13 6432(4 Baseline Week 13 643272 Baseline Week 13 643290 Baseline Week 13 6432 Baseline Week 13 (43DS Baseline Week 13 MANIPULATIONS IN MA MONITOR S u co <o 3H OH 3 C5 < CO uCELc H< PREUSPIPLOLNASREY uwWQoH<zHH oZ HH < P iftiilMW lIW 0 I I 0 I WiBBLi B B ijiill 0 ' 1m 1 i 0 . 0 118111ittiM B B l n m i l l 0 000 011 mm1 1 1 I 1 liM lii l l l g l i l l i IB illB B i 000 0 0 0 w 1 H8M 0 0 Ig lli-K 0 m a 0m ill 0 0 1 1B88M 000 W S S0 i n 1 m i% i WBIBiMIII I 1 B I iB B IB H mi l l Ifillf n u m i ai0 0 0 010 iBiM fii}m m IliflB liS i H i lii ili lt0 0 ifllli 0 lillU B B I I I B 0 Ba illgi tm li 0 iliiMBMIHI B 0 B i i 0 a i i i llSiii0lft i l 1 l! ili lIHIII0ltiBS0 i0 IjMfciBHiiilll iim0 ii ( i 0 l l m i0 000 00 1 699 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group V: 100 mg/kg/day MANIPULATIONS IN MA MONITOR <uX oOu3C >- CO SH 35 Oh Q << e5 lH uX 5Oh <H o' W <s p5OHh 22CwO foUWOWQH<Ch OH2 c 5 643175 Baseline . - w m . 0 H M H U H i m B B l Week 13 a 643224- Baseline^ ' ' ' ' ^ 0 fSI B M l 9 H 3 B S . ! Week 13 000 000 643243 Baseline gallili _0 a l i i i l i B I B i l 1 1 1 1 1 B i i i i n s -m Week 13 -i 0 0 0i i 643247 Bastimi. s m ^ 0, i l M H i s m b iU B I M 0 Week 13 -643250;,, JBasclinc Week 13 - 0 B flilB il 0 0 JajB^g!S!ft!B0SB| O l I l l i B l M 0 fg i f l W 0 M I 000 0i 000% 643257 Baseline Week 13 643275 1Baseline ' 1 1 1 1 B 00 , -0r- * 0 0 mO&mmmUKm00mBM1-VBumpSS*i$HB:1i*liwSr-Wpk11S3i mmWeek 13 000 000 m i--643311 Baseliia. Week 13 H A H0 B iltB B i 0 0 0 m ilM B K Iilig l i H ill 0i l 643314 Baseluu. WWIWIilMIliWii Week 13 00 0 numin i ' 0 0 000 643318 Baseline Week 13 i u n 0 ilB B M i o' gB IB ilillilB B 00 0 T i n0 baASadcdriitfiiocnedalionbesxetrrveamtiiosnpnriootretdo-eSvoarlue,atriiognh.t axilla. H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Male Rats/Group VII: 250mg/kg/day MANIPULATIONS IN MA MONITOR STIMULU TAIL PINCH 1 |j1PRUEPSIPLOLNASI 33 U33 <SS ho q !* aOi CO H %% < b O ZOMH s 2wUQh H < Z2D 643151 643165 643220 643225 643234 Baseline , Week 13 Recovery Baseline ' > Week 13 Recovery Baseline Week 13 Recovery a Baseline -. ' Week 13 Recovery Baseline .7 Week 13 ' . '`0 0 0 B M im 0 0 i l l i l0i 0 "- 0 0 0 1/, 0 0 `-~a- 0- U ftg : 00 00 sj0jjBp i l0 l 00 00 00 00 00 00 00 j|jr t g m u 00 M i i i t e a i 0 0 0 0 iia 0 0 0 0 0 i i B il 1 1 ft iai 0 1 llIp iB 1 0 SSSBlSI 1 1 fltfftiBiS; 0 0 0 1 1 1 0 0 1 1 ;;o 0 11 Recovery 000 000 643236 Baselii i Week 13 llSBlfti 0 0. 0 0 piBiHs(li 0 _ 0 0 010 Recovery 000 000 643258 Baseline Week 13 Recovery 643266 Basinc' ni.IIS IIot 0 0 0 0 0 0 0 0 iilBSSl0lli1iii 01 0 . 'o . M a i hiaM 0 1 1 Week 13 Recovery 000 00 0 000 011 '643296i Baseline' Week 13 Recovery iilIiiriBii 0 iiisiMr.ifc,i"*CVariEli"Vi*i;igijlci-irirlijfetSSi-' 10 0 0 0 0 10 , 0 0 1 0 643316 Baseline Week 13 Recovery lBBlfj 0 0 sttilfi 0 0 0 iiiwiBiiliffiaiiBia 0 0 0 00 0: 1 1 1Additional observation noted - Ptosis. 701 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generationjcproductivej5valuations^ DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group II: 0 mg/kg/day MANIPULATIONS IN MA MONITOR AAPNPDRTOOAUCCHH SATUIDMITULOURSY TAIL PINCH PRUEPSIPLOLNASREY DEFECATION URINATION 643330 Baseline Week 13 Recovery 6v4/iS3Si3v'ir3^6?^-. Baseline Week 13 ,M 0 -, o. 0 0m 0 000 l i t t f l l i i MBlMiiBWl i t e 000 B 0 0 O O* 0 '0 00 1 0 0 b. ......01If$5 643377 643387 Recovery Baseline Week 13 Recovery Baseline Week 13 a iH l i 0 l U B 0 S l S 0B il 0 000 0 .. ^ ll 0 lifclll iiit 0 0 0 ..... 0 Recovery 000 0 0 t-_yHin'iiT1s: 00 11 0 iM ii 1l 01 643405 643415 643425 ' 643426 643448 643453 Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline Week 13 Recovery Baseline' . Week 13 Recovery Baselin Week 13 Recovery Baseline Week 13 Recovery ipM lit ftf 0 il# 000 011 000 011 I l i i B IB M ll 0 i l l i n i l 000 0 0 g ii| 10 000 00 1 IliiillSiiiil S lililil 0 llBMiBItlllfllK m m 0 000 000 000 000 a i t i l i --i l ffc lM ii l lfcIIttilMlrtftifflM i g jjg j 000 000 000 000 illiil mm 01 000 000 0 .0 0 M l0 00 iB B 01.X* ..... 0 0 0 000 000 000 aSacrificed inextremisprior to evaluation. 702 ompany Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group IV: 25 mg/kg/day MANIPULATIONS IN MA MONITOR 643321 Baseline uX U 0$ UD) <o & < z< P< 1&Ho XuzJ<H ' wKSBKs 1 1 1 <7 dDxu,gC/5 oz %uw Ut ih zoH< E CL. Oh Q flBBSiiiB llllf o; ; Week 13 a 643324 Baseline Week 13 643364 'Baseline Week 13 643380 - Baseline Week 13 643389 BWaeseeklin1--e3..... 643390 Baselin Week 13 643396 Baseline Week 13 643410 Baseline Week 13 643,433 Baseline Week 13 643458 Baseline Week 13 " , ',, -.-'ga,,i.IBlli-arilaIl'itiIB:FlmfiMHcil^'lo0Bi00on0000i000utiitW1MfiliBlaWI-lIBi0000000Si0l00ililigiIfliimIijBBiIifB00000H0I0lW00m8imS8iai1MpnB1Bihil1iIliig1lltMlU#liBlr8i'tiTjg.Mf'rSiifn;=clir00r0i000r00j0ir0B0iaM'iljaiS'iliijMfiiffjaisitlgiMAiSiaisj00W00i0lf00j0i0alffiBraclBltSttggleilti.S8M0I0101.01B50100100i;` Sacrificed in extremis prior to evaluation. 703 Company Sanitized. Does not contain TSCA C Bf H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group VI: 100 mg/kg/day MANIPULATIONS IN MA MONITOR AAPNPDRTOOAUCCHH SATUIDMITULOURSY TAIL PINCH PRUEPSIPLOLNASREY DEFECATION URINATION 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Bast line Week 13 Baseline. Week 13 Bastiin. Week 13 Basi Im. Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13 Baseline Week 13 - ' , H B B im 0 m 0 B B iM B 0 0 o0 0 V -'o 0 0 0 0 MSt 0 M1il 10 :h'k-k:Ui? -0i i l l 00 WStm i t 00 m b s 0 IB S iM 0 I W t0 |i | 0 00 lalB iliillj | 0 WfBBS g 0 jM M B 0 1 _ i m 0M i a i s0 m g j^ 0 lIJ 0 0 "O . 0 0 0 lllill ' *01'I 0 l f 1c BB 0 w -. ' H fi .. 1 0 1 . "'m001m. 0 m00i' IB IlB iiiB iIjflKHllliffiM BK p i i lifc m lih l 0 -l 0 J l i i l U t t fiBBSHIa m 000 n 0 aghffliiig 0 00 0 a'vi-i+a>"a.-insis 0 lillS lI I bliiiB illl lliliiS .. 8 000 000 704 Company Sanitized. Does not contain TSCA CBi H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY ASSESSMENT Female Rats/Group VI: 250mg/kg/day MANIPULATIONS 643345 Bastimi Week 13 Recovery 643347 Baseline Week 13 Recovery 643351 Baseline Week 13 Recovery `r643358V:Baseline Week 13 Recovery 643423 Baseline - Week 13 Recovery 643441 Baseline Week 13 Recovery 643444 Baseline Week 13 Recovery 33 U< Q UXOPQH >"oo gH PPO 2 3 5 3< CHO 33 u5 04 J--( < H 0" ^ o . o 00u 000 aillME 'o 00 0 000 i||i||( b 0 000 000 HH 0 ' 0 000 000 . .a p a a i aMfe 0 00 000 000 000 0 00 000 000 IN MA MONITOR I " H Z O <H Q l U< BJ h C/3 tu, os W Pu, Pi fc iilB Wm 1 0i 1 000 BMMi 0 , 0 000 000 i m i (1 l i 000 00 1 .'Vm0JS-4.-' - j p l 8 0 10 000 onm 000 000 m m 0 18111 00 1 000 1IB8I1jj 1 011 00 1 S a S sS t ' ....... Week 13 0 0 Recovery a,c 0 643474 Baseline H M H K " Week 13 0 Recovery 643481 Baseline -- 0 IS Week 13 0 Recovery 0 I) 0 0 1ssa0aosE: 01 0 00 afflai^B ttB iiiiifflWHMl 00 0 0 00 01 iss M s w B liS 00 01 00 00 u 1 1; 0 0 1 1 0 *Additional observation noted - Scratch, right comer of eye. bAdditional observation noted - Ptosis. cAdditional observation noted - Chromodacryorrhea. 705 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX I INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: DURATION OF MOVEMENTS 706 Company Sanitized. Does not contain TSCA CBi H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Male Rats/Group I: Omg/kg/day Animal Number Successive 10-Minute Intervals 1 2 345 643162 643172 643195 666444333222234676 643253 643262 664433330034 553 338997 492 500 440413 365 432359 442800159 436 229992 287 204 161 359 447 310936 408 286 241 221493734 194 8100 239610 319 321026 66 156 70 19 446 127 235 179 41 341 17 6 Total 27 1611 01 1840470 8140 11873233 34 1453 161550 1893339544 0 1065 Male Rats/Group HI: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 12 345 643173 666444333121782098 643240 664433226742 664433229902 643308 391 429 339611 388 486 434088377 464 252 332208262 306 468 245 268 382 454 69 331 296 299 41875154 172 305 386 23 56 5 3354 259 1060 160 189 02 5 5 451 121 9 26 6 Total 60 1714410 9 1012 0 982 1 901 81 1775110 1 940 20 1363 3 1522 707 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Male Rats/Group V: 100mg/kg/day Animal Number 1 Successive 23 10-Minu4te Interval5s 643175 643224 643243 664433224570 643257 643275 664433331114 643318 454 444234 336289 438686 433722 353 386 385 222749189 262 430064 366 292 370 344 257 115335 53 76 217173 185 122 319519 17 775 3 113 4294 5 260 29 0 1 3302 37 17 6 6 Total 25834 2 60 1340 2089 1814339 789 716 183 53 11 17 11911885886 877 Male Rats/Group VH: 250 mg/kg/day Animal Number I 2Successiv3e 10-Minu4te Interva5ls 664433115615 643220 643225 643234 666444333222536866 643296 643316 357 445344 415 405 331052 437354 433 267 366 271 233630769 159 255 361 280 213 36960 232 298 147 129 25110 41 33 2132941 195 1 12 1076 11 0 256 0 1430928 1 0 26 0 6 Total 0 120 204 870 1801 796 1164 60 238 6 2 2 5 11630441352 990 839 770 708 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Female Rats/Group IT. 0 mg/kg/day Animal Number 643330 664433333767 643387 643405 666444333444122556 643448 643453 I 2Successiv3e 10-Minu4te Interva5ls 6 Total 389 384 316 334010 374 459 381 430614 440 217894 236 260 272 421597 388 305 249 289 10 215334 47 119 222820 26 27 212811 196 2577 301 214 24096 0 9131 220 116680 189 208 23250 1 1106 3 1187 9 2402 1719035 1314 27 7 1930 1849954 1475 1303 11 982 Female Rats/Group IV: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 1 234 5 643321 643324 643364 666444333333889090 643396 643410 643433 643458 361 437319 388 384 382 444101572 438 290 335 287 231027 160 278 366 289 331 261 313950 189 221288142 376 263 193 222 298 53 29 22678837 111 185 2 27116 0 237 162 1648 2155 8 6 Total 5 110 1028 32 1 50 07 1150 1720 982 11135374 1204 1112 1273 1371 7 979 709 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generationjcproductive^Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Baseline Female Rats/Group VI: 100 mg/kg/day Animal Number Successive 10-Minute Intervals I 2345 643322 664433332636 643367 643392 643409 664433446612 664433447829 506 351 443528857 443392182 334682 455 294 369 326984 329611 324927 198 454 74 13 221004 232 23 26682 153 494 0 215192 209 257 3 3158 133 438 10 4912 125 72 12 3190 85 6 Total 420 2767 37 16 19 2 115 11721607666 1221 1388 708 12 2626 1714118 1193 Female Rats/Group Vffl: 250 mg/kg/day Animal Number Successive 10-Minute Intervals 643345 643347 643351 664433345283 643441 643444 643457 643474 643481 416 278 339 333825006 331 413 382 428 324 251 290 361 214894 77 276 284 318 320 311852 120 245 314122 276 63 248 390 48 3635 162 10 268 1485 238 348 346187 209 7 40 5 0 18 Total 351 1 2251 2174790 1870 935 73 3 0 754 1719382 1058 1193 738 2 1252 m ---------------------------------------------------------------- 7 fjtewpawgaaiWiafl. Poonot contain TSCACB1 H90--2D45ay16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Male Rats/Group I: Omg/kg/day Animal Number I Successive 23 10-Minute 4 Interva5ls 643162 643172 664433129256 643237 643246 664433225632 643303 643304 485 419 378 443304 384 432594 383 370 417 268 263 316 265 239054 277 239116 231 225620 297 231 223914 185 131 214 56 190 187 310713 156 210319 133 203 55 205 212216 171 83 14 5715 155 6 Total 19 153 209 222707 9 12722 1 1263 1487 1523 1687 11514598 1369 1008 11021559 Male Rats/Group IH: 25 mg/kg/day / Animal Number 1 Successive 10-Minute Intervals 2345 6 Total 643173 643179 643180 643228 643240 664433226742 643290 643292 643308 433206116 329 369 435988 368 430 478 260 316 301 215733 363 287 260 361 397 226 224 336 118920 207 126 127 326 237 114 206 329 211186178 15 4 165 322 4 176 133 155 112884 11 7 10 183 32 937 56 88 171 11060132 4 54 47 11535939 1227 1222 1482 1973074006 1664 711 mkd.DoseiraoeomSataTS 0t H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Male Rats/Group V: 100mg/kg/day Animal Number I Successive 10-Minute Intervals .2 3 4 5 6 Total 643175 a 666444333222442374 643250 643257 643275 664433331114 643318 333568114 340 434015 306 395 431 322012389 260 269 316889 274 345 252 270 22104157 313 129 317 353 234 249 2129 154 321 15157 267 147 183 0 182 230317 125 242 123 9. .8. 141 8 186 1457 25 665 186 1387 0 1180 178 1922 91 955 187 1472 265 1784 Male Rats/Group VH: 250 mg/kg/day Animal Number 1 2Successiv3e 10-Minu4te Interva5ls 664433115615 643220 643225 643234 664433225386 643266 643296 643316 238858 440 296 299 339054 357 438 482 147 340 289 22713 298 300 236 399 345 45 340 2245906 230 156 177 369 279 24 221 228 183 3 113550 115 305 105 4 138 155 21634 138 92 120 240 288 6 Total 1323 508 1559 29 66 13 21282 11423359160 1224 1214 16 1021 160 1911 269 1768 a Sacrificed in extremis prior to evaluation. 712 Company Sanffizdd. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Female Rats/Group H: 0 mg/kg/day NAunmimbaelr 643330 664433333767 643387 666444333444012555 643426 643448 643453 1 2Successiv3e 10-Minu4te Interva5ls 6 Total 433 430152 321 402 399 453 237788 340 296 270 204 221655 332 370 192 220860 197 321 242 277 220 231552592 63 172 189 116277 217 205 283 148 214 115 77 191 66 114910 126302 123 103 50 226894 1242 1620 1238 152 12 152 0 30 242 11327452 1581 1332 673794 1252 Female Rats/Group IV: 25 mg/kg/day Animal Number I 2Successiv3e 10-Minu4te Interval5s 643321 a 664433332644 664433338809 643390 643396 643410 643433 643458 499 427 396 428 358220 420 336 476 4304..76. 231 376 278 429 372 313353 ,,, 306 247 202 306 246 226 304 29 282 315 252 196 148 8270 249 199 29 361 18 11205224 64 138 11 37 6 Total 258 114 102 111514 21048655 1229 1391 1301 136 1395 222 1705 8 716 270 1429 aSacrificed inextremisprior to evaluation. 713 (aaapamSanRIs@dL0esffssa TSCClf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Week 13 Female Rats/Group VI: 100mg/kg/day NAunmimbaelr 643322 643323 643366 664433336972 643409 666444333444667122 643489 I Successive 10-Minute Intervals 2345 6 Total 521 312 412 456 288 434886 393 239540 376 315804 314776 300 265 312587 178 401 30197 241 106 233310 226 130 27 380 1 245 22417570 177 3712 1 660 245 297 79 1187 245 158 211 5 1749 115 256 4322 161 181 112115 11685219978 11743225886 1339 931 82 849 Female Rats/Group VIH: 250 mg/kg/day Animal Number I 2Successiv3e 10-Minu4te Interva5ls 643345 664433335417 643358 666444333444424134 643457 643474 643481 426 234942 335607 308 471 434857 321 212777 347 263 223 420476 249 261 277 15 118 248 112339 97 267 298 28 148 116380 83 185 87 111174 296 4 207 232 111 81 8115 145 45 21153382 6 Total 25256 1323 806 237 9 14 962 11830831879 912 1403 63 1504 149 867 54 1219 714 COBipany Sanitized. Does not contain TSC4 (Sf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproducti.ve Evaluat.ion____________________ nunuPrormntt-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Recovery Male Rats/Group I: Omg/kg/day Number 643162 643172 643195 643226 643237 664433225436 643262 664433330034 Successive 10-Minute Intervals. ! 2. 2. - - 279 423 321916 236 333229 384 268 382 211387374 154 187 217587 249 158 246 123 154 130 15029 160 164 111919489 77 111 131 113087 111 212972 129 222 1897502 91 92 115447 126 58 192 6 Total 82 833 173 1264 110317 983698 64 795 98 1133 221155 11230990 108 839 205 1446 Male Rats/Group VII: 250 mg/kg/day NAunmimbaelr 2Successiv3e 10-Minu4te Interva5ls 643151 643165 666444333222223504 664433223568 664433226966 643316 278 321 310 213927 302 388 289 328 304 193 220 210912 168 177 272 153 142 126 174 211337 202 99 133 137 15898 132 150 211104 193 53 82 169 113207 85 117 117354 139 67 207 99 14049 113 6 Total 111 1023 192 1254 168 1141 1103 1056887 54 955 193 1258 70 745 137 1031 125 885 715 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: DURATION OF MOVEMENTS (sec) Recovery Female Rats/Group II: 0 mg/kg/day Animal Number 643330 664433337376 a 643387 643405 643415 664433442256 643448 643453 I 2Successiv3e 10-Minu4te Interva5ls 6 Total 307 381 321058 384 322 330 333837 160 214865 137 316 226228 204 267 146 20..1. 119617 221 127 160 177 166 132 16..8. 109 65 26712 198 171 234 74 16..9. 79 110 17197 76 72 174 201 1020 12..8. 15157 129..3. 1034 704 1 1263 90 989 113190 11103617 90 1318 m Female Rats/Group VIII: 250 mg/kg/day NAunmimbaelr Successive 10-Minute Intervals I 2345 6 Total 643345 643347 643351 664433342538 643441 643444 643456 643474 643481 223692984 267 379 254 345 312855 327 25 146 220 215646 110 216 56 185 152 13994 132 38 233 2387 21219 112 0 95 55 215204 6796 0 61 127 0 50 31 641097 73 1 18 113 97 13932 430 812 958 22 673 187 1356 1711275 578639 348 114 914 75 906 Sacrificed inextremisprior to evaluation. 716 JSpfflpajss?Sanitized. Doesoofeenfatn mem e? H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 APPENDIX J INDIVIDUAL MOTOR ACTIVITY ASSESSMENT: NUMBER OF MOVEMENTS 717 H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluation^ DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Male Rats/Group I: Omg/kg/day NAunmimbaelr I 2Successiv3e 10-Minu4te Interva5ls 643162 643172 643195 664433222367 664433225436 643262 664433330034 57 124 124 88 96 112338 161 114464 68 113130 93 103 135 113306 121 117 81 141 111401309 112 142 114404 116 23 12164 109 115 112304 6988 72 3 4123 79 133 11511 342 21 6 Total 4 2 4 10 5317 76 4 130 245325660 466741937 666 551534 470 Male Rats/Group HI: 25 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2345 643173 664433117890 643228 643240 643264 643272 664433229902 643308 128 122 110 114416 66 136 119 91 109 143 134 128 120 12672 135 147 102 114 11740557 137 121 6552 118 140 112 14 378 3213 5164 19096 116 0 35 6 3 102 18 8 32 6 Total 9 0 103 5 4 6 116 369 443 434690 420 263 345 507 458 3 486 718 empaira? S a m S to io @s n o t ssitalmi T i C A C M H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVHY: NUMBER OF MOVEMENTS Baseline Male Rats/Group V: 100mg/kg/day Animal Number Successive 10-Minute Intervals 1 643175 643224 643243 664433224570 643257 643275 643311 664433331184 93 107 135 121 111124157 141 111420 19217 145 130 109 115117 154 151 154 142 134 111411568 57 58 14809 112 81 19154 2622 9 8 9300 39 6 12387 41 28 26 3189 12 Total 11 430 1165 752594 2 13 781 439313 391 398 2164 19 541859 476 [ale Rats/Group VII: 250 mg/kg/day Animal Number 1 Successive 23 10-Minu4te Interva5ls 643151 664433126250 643225 643234 643236 643258 664433226966 643316 156 113204 141 152 114442 114232 125 181 139 121 114317 137 124 138 155 130 134 171 54 111332024 93 145 12 25 15647 4 65 110 237 95 9 7 1551 1 78 48 213 4 11 1 6 Total 0 90 0 6154 526 852 304 570 643 145 6 5 9 8 539718 530 318 296 719 CoopanySanitized. DoeenotcontainTSCA C8I H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Female Rats/Group H: 0 mg/kg/day Animal Number 1 Successive 10-Minute Intervals 234 5 6 Total 643330 664433333767 664433340857 643415 643425 664433444286 643453 121 112316 153 142 145 110515 125 137 124 147 145 111325159 109 115215 150 130 125 15 110288 47 11744902 24 12287 143 132 126 11154 100 125 37 2 1130505 139 142 94 12306 155 4 117 28 431070 125 4 15 409 547 535 668977 547 585140132 518 Female Rats/Group IV: 25 mg/kg/day Animal Number I Successive 23 10-Minute 4 Interval5s 664433332214 643364 643380 643389 643390 666444333344913360 643458 161 141 106 112209 136 122 146 120 121 113687 124 106 149 114184 151 149 122 115596 100 130 111324899 122 152 117 114784 32 38 158 161 72 182846 16189 2 106 128 99 119 92 8 6 Total 7 104 728 693120 372 572 28 721 3 31 655311 2 12 12 655210 384 m _________720___ :_____________ gempang BenoteonalnTS6& H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Baseline Female Rats/Group VI: 100mg/kg/day NAunmimbaelr 1 2Successiv3e 10-Minu4te Interva5ls 643322 643323 643366 664433336972 664433446019 643462 643472 643489 72 136 109 80 114198 132 139 115452 67 125 155 111263247 124 131 112174 73 7113 122 127 10177 11530 103 75 98521 147 1317 3119 75 69 5155 34 115 50 21585 63 6 Total 78 434 23 371 14 441 16 458 1393 735005132 18 457 15102 637487 Female Rats/Group VEI: 250 mg/kg/day Animal Number 1 2Successiv3e 10-Minu4te Interva5ls 643345 643347 664433335518 643423 643441 643444 664433445774 643481 136 129 147 115450 152 125 112312 118 161 134 154 114339 163 46 105 135 144 152 157 172 19249 107 131 133 15384 146 51 1386 14131 149 124 6 129 166 9 15264 146 3156 11 0 25 6 Total 1634 942853 1446 485832 77 778 51 445874 597 536247 4 554 721 eompM Sanitized. Does not contain TSCA H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Male Rats/Group I: 0 mg/kg/day Animal Number 1 Successive 23 10-Minu4te Intervals 5 643162 664433117952 643226 643237 643246 643253 666444333233600324 58 134 111520107 124 112524 172 142 66 125 127 113 112 111399 111635634 11430296 104 102 110398 135 94 121 14 113 1937197 84 107 110036 114 9 115 125 5864 53 21 4787 97 6 Total 3 95 138 19159 192 721 745 620 601 11 70 78 2 550907 616 660089 Male Rats/Group DI: 25 mg/kg/day NAunmimbaelr I Successive 23 1C1-Min4ute Intervals 5 643173 664433117890 643228 643240 664433226724 643290 643292 643308 111212788 160 141 19483 114289 97 126 81 110 19207 111322 111256 126 126 109 99 110213 89 72 101 142 94 60 82 105 998568 6 .5 98 84 8 10616 100 65 819 8 15 64 6 Total 3224 479 515 51 559 88 83 4581 4 663336 516 431932 32 531 24 489 722 mpatj SsKlzed. Dees oteonflraTTSCB H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Male Rats/Group V: 100mg/kg/day NAunmimbaelr Successive 10-Minute Intervals 12345 664433127254 643243 643247 643250 664433227557 643311 643314 643318 133 161 139 210584 123 167 113378 144 142 111237104 115 127 123 147 113632 34 119 11390287 135 153 110614 2 11182127 110 33 136 111432 2 109 111125104 126 91 6 Total 63 687 151 12136 922 372432 851 752 672 75 99 140 687 685035 Male Rats/Group VR 250 mg/kg/day Animal Number Successive 10-Minute Intervals i 2245 643151 643165 664433222250 643234 643236 643258 664433226966 643316 162 112309 114342 155 143 113110 109 97 127 139 16180 144 150 114111 128 47 129 124 138 1269 111000312 96 28 19251 1145 92 123 16051 59 170362 132 54 93 74 69 106 146 6 Total 786 39 56 14 13212 346 662624 702 271 644 715 181964 517 661552 *Sacrificed inextremisprior to evaluation. 723 Com pany Sanitized. Doss not contain TSCA CBf H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Female Rats/Group H: 0 mg/kg/day NAunmimbaelr Successive 10-Minute Intervals I 2345 643330 643336 643377 643387 643405 664433441255 666444333444452836 139 113510 161 147 157 111676 122 141 124 127 113 114174 158 115 114310 149 69 137 113416 128 111351397 66 111 84 81 80 114122 154 97 25 938 52 8887 113 95 135 5 3713 31 6 Total 36 135 140 12131 504 699 701 832 607 142 5 61 145 490752 475 461710 Female Rats/Group IV: 25 mg/kg/day NAunmimbaelr 2Successiv3e 10-Minu4te 643321 a 664433332644 664433338809 643390 643396 643410 643433 643458 125 122 113552 153 49 123 139 113 111331404 162 127 67 19228 133 112099 19584 15313 151 18 115 146 119 110097 65 4 112337 26 5 134 14 2876 121 8 105 12 26 6 Total 12577 795 551 58 81 12204 660812 713893 1238 767 392 128 541 aSacrificed inextremisprior to evaluation. Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Week 13 Female Rats/Group VI: 100 mg/kg/day NAunmimbaelr 643322 643323 643366 664433336972 664433446019 643462 664433447829 I Successive 10-Minute Intervals 2345 6 Total 65 161 132 115033 112 146 111643329 56 112130 130 129 128 114454 107 108 2514 141 129 86 112086 125 87 33 53 1 137 15068 105 128 23 563 13 1272 118 83 2103 123 121 147 1 82 141 34 11310784 596527 239 380 801 652424 575 678 663019 495 Female Rats/Group VI: 250 mg/kg/day Animal Number I 2Successiv3e 10-Minu4te Interva5ls 643345 643347 666444333343525138 664433444414 664433445774 643481 116 112318 152 156 11806139 134 143 112 123 136 132 127 113262 101 123 138 14 77 135 19160 100 134 112 25 110 101 8735 122 93 95 54 1135328 127 76 79 951309 24 83 21 127 6 Total 101 12335 571 503 698 18 587 25 516 587 4936 459913 561 407 48 718 725 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Recovery Male Rats/Group I: 0 mg/kg/day Animal Number 1 Successive 10-Minute Intervals 2345 6 Total 643162 643172 643195 643226 643237 643246 664433225632 664433330034 134 12828 115330 146 140 152 112412 17309 91 17329 136 19280 90 109 105 5727 21 78 99 1098126 89 64 52 79 81 7718 117 99 7877 61 67 60 54 1870182 89 16136 65 56 77 86 1471580 100 16157 568 350910 451 652640 666496 524 634 Male Rats/Group VU: 250 mg/kg/day NAunmimbaelr I Successive 10-Minute Intervals 2345 643151 643165 666444333222232540 643236 643258 643266 643296 643316 111354604 131 96 112126 164 128 124 131 111029 16064 95 102 87 85 68 123 18056 98 965326 35 81 75 100 18326 126 42 6736 67 74 36 77 102 499546 100 50 33 66 61 6 Total 87 662 118 687 181587 660 631412 39 505 90 503 49 435 93 527 72 436 726 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL MOTOR ACTIVITY: NUMBER OF MOVEMENTS Recovery Female Rats/Group D: 0 mg/kg/day Animal Number Successive 10-Minute Intervals 1 2 345 664433333306 643377 643387 643405 664433441255 643426 643448 643453 134 123 101 100 58 126 115226 135 139 111543750 111310286 152 132 130 115219 98 111332 129 108 18247 105 110114 69 155 76 112296 119 116 17002 6962 62 64 87 Total 155 671 102 12164 845 110044 55 688 659390 642 667361167 625 Female Rats/Group VHI: 250 mg/kg/day Animal Number Successive 10-Minute Intervals i 21- - 643345 643347 643351 664433342538 643441 643444 664433445764 643481 153 113574 142 117 111442295 149 136 18 110338 126 118 18454 45 112059 30 19192 56 117 38 55 12296 82 0 7483 101 122 5602 661 93 0 47 42 4522 22 89 3 28 85 Total 69 43 12392 121 84 34 4997 87 257200 605 560397 452313 252 591 592 8Sacrificed inextremisprior to evaluation. 727 Company Sanitized. Does not contain TSCA C 8i H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 APPENDIX K INDIVIDUAL CLINICAL PATHOLOGY DATA 728 Company Sanitized. Does not contain TSCA C8f H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES ABBREVIATIONS : General: ADEQ - adequate CLOT - sample clotted DECR - decreased NSR - no sample received for testing NT - not taken or not performed NT-HEMOL - not taken due to hemolysis greater than or equal to moderate OK - sample condition OK for testing QNS - quantity not sufficient RNV - result not valid UTD - unable to determine > " greater than < - less than Individual Hematology Values: COND - sample condition RBC - red blood cell count HGB - hemoglobin HCT - hematocrit MCV - mean corpuscular volume MCH - mean corpuscular hemoglobin MCHC - mean corpuscular hemoglobin concentration RDW - red cell distribution width ARET - absolute reticulocyte count WBC - white blood cell count ANEU - absolute neutrophil (all forms) ANPR - absolute neutrophil precursor ALYM - absolute lymphocyte AMON - absolute monocyte AEOS - absolute eosinophil ABAS - absolute basophil ALUC - absolute large unstained cell ABLT - absolute blast leukocyte AMSC - absolute miscellaneous leukocyte PLT - platelet count SPEC - special observations AL - atypical lymphocyte HSN - hypersegmented neutrophil 729 Company Sanitized. Does not contain TSCA C B t H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) ABBREVIATIONS : (Continued) Individual Red Blood Cell Morphology Values: NORM - normal ANIS - anisocytosis MIC - microcytes MAC - macrocytes POLY - polychromas ia HYPO - hypochromasia ECHI - echinocytes ACAN " acanthocytes TARG - target cells RX - rouleaux HJB - Howell-Jolly body SPEC - special observations -- " not observed or not examined; see whole blood sample condition Individual White Blood Cell /. Platelet Morphology Values: NORM - normal SM - smudge white blood cells DB - Dohle bodies PC - platelet clumps (graded as 1 if present at any level) GP - giant platelets BP - bizarre platelets TOX - toxic neutrophils VC - vacuolated cytoplasm SPEC - special observations -- - not observed or not examined; see whole blood sample condition Individual Coagulation Values: PHEM " plasma hemolysis PLIP plasma lipemia PICT - plasma icterus PT - prothrombin time APTT - activated partial thromboplastin time 730 Company Sanitized. Does not contain TSCA Crf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) ABBREVIATIONS : (Continued) Individual Serum and Plasma Chemistry Values: SHEM - serum hemolysis SLIP - serum lipemia SICT - serum icterus AST - aspartate aminotransferase ALT - alanine aminotransferase SDH - sorbitol dehydrogenase ALKP - alkaline phosphatase BILI - total bilirubin BUN - urea nitrogen CREA - creatinine CHOL - cholesterol TRIG - triglycerides GLUC - glucose TP - total protein ALB - albumin ' GLOB - globulin CALC - calcium IPHS - inorganic phosphorous NA - sodium K - potassium CL - chloride ., PHEM - plasma hemolysis from blood sample for fluoride determination PLIP _ plasma lipemia from blood sample for fluoride determination PICT - plasma icterus from blood sample for fluoride determination PFLU - plasma fluoride SPEC - special observations Individual Urinalysis Values: QUAL - quality (modifies color) COL - color CLAR - clarity VOL - volume UOSM - urine osmolality SG - specific gravity , PH - the logarithm of the reciprocal of the hydrogen ion concentration UGLU - urine glucose KET - ketone UBIL - urine bilirubin BLD - blood URO - urobilinogen UFLU - urine fluoride UMTP - urine protein SPEC - special observations Individual Urine Microscopic Examination Values: EPIT - epithelial cells UWBC - urine white blood cells URBC -- urine red blood cells NCRY - normal crystals MICR - microorganisms SPER - sperm SPEC - special observations _ ' 731 Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA EXPLANATORY NOTES (Continued) KEY: Red Blood Cell Morphology Values, White Blood Cell / Platelet Morphology Values exception of Platelet Clumps), and Special Observations: 1 - trace 2 - few 3 - moderate 4 . - many (with the Urine Microscopic Values : EPIT NCRY/MICR SPERM/MUCUS per high power field (4Ox)______ per high power field (40x)________per low power field (lOx) few - 1-10 moderate - 11-50 many - >50 few - 1-25%/field moderate - 26-50%/field many - >50%/field 1 - 1-5 2 - 6-20 3 - >20 NOTES : When individual animal data are not reported, it may be due to one of the following reasons or other reasons, all of which are explained in the study records: the sample was clotted (for hematology or coagulation data) there was insufficient sample for analysis (QNS) a valid result could not be obtained (RNV) the sample was not suitable for evaluation the animal died prior to sample collection no sample was available for analysis (NSR) (CLOT) When an individual observation was recorded as being less than a certain value, calculations were performed on half the recorded value. For example, if bilirubin was reported as <0.1, 0.05 was used for any calculations performed with that bilirubin data. 732 ptapmi Sanitized. Does not contain TSCA CBf 9H0--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number COND RBC xlO a6/u L HGB g/dL Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 OK 7.72 14 ,.4 OK 7.77 15,.i OK 8.21 14,.7 OK 8.64 15,.2 OK 8.18 15,.1 OK 7.79 14 ,.9 OK 8.04 14 ,.9 OK 8.37 15,.8 OK 8.51 15,.1 OK 8.96 16 ,.0 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 OK 8.38 15,.7 OK 8.48 15,.6 OK 7.97 14 ,.6 OK 8.09 15,.0 OK 8.38 15 .5 OK 8.16 15,.2 OK 8.67 15-,.6 OK 8.62 15,.7 OK 8.42 14..8 OK 8.18 15,.6 Individual Hematology Values HCT MCV MCH MCHC % fli pg g/dL 44,.3 44 .9 45..2 46,.4 46,.4 45,.9 43 ,.7 48,.0 45,.8 49,.6 49..0 46..9 44 ,.2 46..3 46..3 44,.2 47,.2 47 ,.9 46,,1 47,.4 57..3 57.,7 55.,0 53 ,,7 56..7 58 .9 54 .4 57..4 53 .,8 55.,4 58 .,5 55..4 55.,5 57. 2 55. 2 54 .2 54 .5 55. 6 54 .,8 57.,9 18.,7 19..4 18.,0 17.,6 18.,5 1 9 .,1 18.,5 18. 8 17 .,7 17.,9 18.,7 18..4 18..3 18..6 18 .,5 18..6 18..0 18. 2 17..6 19..0 32 ,.6 33 ,.7 32..7 32 .8 32,.6 32,.4 34..0 32..9 32 ,.9 32 ,.3 32..0 33..2 33..0 32 ,.5 33 ,.4 34 ,.3 33 .1 32 ,.8 32..1 32 ,.9 RDW ARET WBC ANEU % x 10a 3/u L XlOA3/uL xl0*3/uL 12,.4 11,.8 12..0 12 .2 12 .1 13 ,.2 li,.9 12 .3 11 .5 12 ,.3 11,.9 11,.6 12 .4 12,.0 li,.2 12 .6 11,.7 11 .7 12..7 12..7 195. 161. 199. 205. 177. 299. 199. 157. 189. 215. 17 .56 17 .58 16 ,.96 20,.09 18 ,.01 19 ,.39 17 ,.08 12 ,.22 16 .01 18 ,.65 198. 188. 201. 177. 146. 216. 141. 163 . 176. 248. 10 ,.72 14 .36 11,.81 20 .04 14 .73 22 .72 21 .83 16 ,.64 13,.63 16..95 4..31 1..86 1..09 3..02 1 .,32 2.,73 2 .,88 1..10 2..57 2..30 2.73 l.,97 2.,88 4 .03 1..43 1..62 2..26 l. 79 2. 13 2 .,29 733 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number COND RBC xlO*6/uL HGB g/dL Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 OK 8.02 15.1 OK 8.24 14.7 OK 8.05 15.2 OK 7.76 14.7 OK 8.09 15.6 OK 7.76 15.0 OK 8.65 16.1 OK 7.33 14.2 OK 7.69 14.4 OK 8.01 15.6 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 64 32*60 643298 643315 OK 8.40 14.9 OK 8.13 14.9 OK 7.85 14.7 OK 8.31 14.9 OK 8.30 14.6 OK 8.03 14.6 OK 7.59 14.7 OK 8.27 15.1 OK 7.46 13.9 OK 8.26 15.3 Individual Hematology Values HCT MCV MCH MCHC % fL pg g/dL 46.1 45.2 47.1 43.3 47.7 45.7 49.1 42.4 44.4 47.2 45.9 44.6 44.8 46.3 45.4 44.7 43.9 45.7 42.7 48.0 57.5 54.8 58.5 55.8 58.9 59.0 56.8 57.8 57.7 58.9 54.6 54.9 57.1 55.7 54.6 55.7 57.8 55.2 57.2 58.1 18.9 17.9 18.9 19.0 19.3 19.3 18.7 19.4 18.8 19.5 17.7 18.3 18.7 18.0 17.6 18.2 19.4 18.2 18.6 18.6 32.8 32.6 32.3 34.0 32.8 32.7 32.9 33.5 32.5 33.1 32.4 33.3 32.8 32.3 32.1 32.7 33.5 33.0 32.5 31.9 # DuPont-5386 RDW ARET WBC AN ELI % xlO*3/uL xlOA3/uL xlO*3/uL 10.8 11.7 11.7 11.4 12.1 11.5 12.5 12.6 12.5 12.1 13.0 12.4 13.3 12.3 12.7 12.4 12.9 11.8 12.7 12.6 186. 154 . 203. 141. 164 . 180 . 204 . 196. 181. 179 . 17.39 13.60 21.89 15.34 23.11 14.52 16.25 24.17 14.81 18.65 202 . 154 . 169. 188 . 121. 207. 184. 185. 164 . 191. 20.43 21.85 25.34 20.48 14.70 20.74 18.75 16.92 16.73 16.93 3.09 2.04 3.21 3.53 2.07 2.00 1.31 2.11 3.45 2.21 3.35 4.80 2.66 2.14 1.45 2.52 2.19 2.09 1.83 1.77 734 Does not contain TSCA e n i ## H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations________________________ Animal ANPR ALYM Number x 10a 3/u L x 10a 3/u L AMON a 3/u L Individual Hematology Values AEOS ABAS ALUC ABLT x 10a 3/u L x 10a 3/u L x 10a 3/u L x 10a 3/u L AMSC x 10a 3/u L PLT x 10a 3/u L o i--! X Male, Group: I - 0 mg/kg - Day 44 643143 NT 12.33 0.34 0.20 0.10 0.28 NT NT 1070 643150 NT 14.86 0.36 0.11 0.17 0.22 NT NT 1229 643185 NT 15.11 0.21 0.19 0.08 0.29 NT NT 1028 643189 NT 16.05 0.57 0.20 0.08 0.17 NT NT RNV 643204 NT 15.87 0.30 0.14 0.12 0.25 NT NT 1242 643205 NT 15.84 0.23 0.11 0.16 0.33 NT NT 1190 643235 NT 13.44 0.30 0.12 0.10 0.24 NT NT 1179 643241 NT 10.41 0.30 0.19 0.08 0.14 NT NT 947 643288 NT 12.56 0.44 0.11 0.11 0.22 NT NT 1232 643300 NT 15.47 0.31 0.19 0.09 0.29 NT NT 1149 Male, Group: III - 25 mg/kg - Day 44 643173 NT 7.30 0.33 0.22 0.03 0.11 NT NT 940 643179 NT 11.53 0.43 0.19 0.09 0.15 NT NT 1171 643180 NT 7.94 0.45 0.31 0.07 0.16 NT NT 992 643228 NT 14.39 0.62 0.16 0.09 0.75 NT NT 1161 643240 NT 12.52 0.32 0.19 0.08 0.20 NT NT 1133 643264 NT' 20.17 0.37 0.19 0.11 0.26 NT NT 1102 643272 NT 18.39 0.41 0.22 0.17 0.38 NT NT 1119 643290 NT 13.66 0.50 0.23 0.11 0.35 NT NT 1128 643292 NT 10.65 0.30 0.26 0.11 0.18 NT NT 943 643308 NT 13.74 0.31 0.30 0.13 0.18 NT NT RNV # DuPont-5386 SPEC 735 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal ANPR ALYM AMON Number xlOA3/uL xl0^3/uL xl0^3/uL Individual Hematology Values AEOS ABAS ALUC ABLT AMSC xlO*3/uL xl0^3/uL xlO~3/uL xlOA3/uL xl03/uL PLT xlO3/uL SPEC Male, Group: V - 100 mg/kg - Day 44 643175 NT 13.19 0.64 0.18 0.10 0.19 NT NT 1384 643224 NT 11.42 0.00 0.14 0.00 0.00 NT NT 1012 643243 NT 17.83 0.41 0.10 0.14 0.21 NT NT RNV 643247 NT 11.20 0.46 0.15 0.00 0.00 NT NT RNV 5%-AL, absolute AL = 0.77; 2%-HSN, absolute HSN = 0.31 643250 NT 20.07 0.28 0.25 0.20 0.25 NT NT 762 643257 NT 11.57 0.50 0.11 0.12 0.22 NT NT 977 643275 NT 14.14 0.40 0.13 0.06 0.21 NT NT 920 643311 NT 20.97 0.53 0.11 0.19 0.27 NT NT 1271 643314 NT 10.57 0.29 0.17 0.14 0.18 NT NT 1315 643318 NT 15.57 0.42 0.11 0.11 0.23 NT NT 913 Male, Group: VII - 250 mg/kg - Day 44 643174 NT 15.84 0.74 0.23 0.10 0.17 NT NT RNV 643193 NT 16.61 0.44 0.00 0.00 0.00 NT NT 963 1%-AL, absolute AL = 0.22; 2%-HSN, absolute HSN = 0.44 643194 NT 21.54 0.45 0.13 0.15 0.41 NT NT 1032 643201 NT 17.41 0.34 0.21 0.12 0.27 NT NT 1163 643215 NT 12.45 0.32 0.18 0.06 0.24 NT NT 861 643252 NT 17.25 0.42 0.18 0.11 0.26 NT NT RNV 643259 NT 15.15 0.61 0.15 0.13 0.52 NT NT 1122 643260 NT 14.00 0.39 0.13 0.07 0.23 NT NT 1049 643298 NT 14.07 0.34 0.16 0.16 0.17 NT NT 941 643315 NT 14.31 0.39 0.08 0.08 0.30 NT NT 936 736 Company Sanitized. Does not contain TSCA C Bt ## H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations__________________________________________ DuPont-5386 Animal Number COND RBC xlO a 6/u L HGB g/dL Male, Group : I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643268 643300 OK OK CLOT OK OK OK OK OK OK OK 8.26 8.55 NT 9.10 8.76 7.86 9.16 9.49 9.30 9.43 14.5 15.3 NT 14.9 15.5 14.3 15.5 16.6 15.5 15.8 Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 OK OK OK OK OK K CLOT OK OK OK 9.22 8.47 8.59 7.81 8.70 8.29 NT 8.80 8.62 8.64 16.8 14.8 14.9 14.0 15.4 14.7 NT 15.2 14.7 15.8 Individual Hematology Values pgHCT MCV MCH % fL NCHC g/dL 46.9 48.4 NT 46.7 50.1 45.4 49.4 54.6 49.8 49.0 53.6 45.6 46.0 43.3 47.7 46.3 NT 47.8 46.7 49.9 56.8 56.6 NT 51.4 57.2 57.9 54.0 57.5 53.5 52.0 58.1 53.8 53.6 55.4 54.8 55.8 NT 54.3 54.2 57.8 17.5 17.9 NT 16.4 17.6 18.3 16.9 17.5 16.7 16.7 18.2 17.4 17.3 17.9 17.6 17.8 NT 17.3 17.1 18.3 30.9 31.6 NT 31.9 30.9 31.6 31.3 30.4 31.2 32.2 31.3 32.4 32.4 32.3 32.2 31.8 NT 31.8 31.5 31.7 RDW ARET WBC ANEU % xlO*3/uL X10A3/UL x 10a 3/u L 13.5 12.3 NT 13.7 13.2 14.7 13.1 12.8 12.7 12.7 12.5 13.5 13.1 12.8 12.4 13.0 NT 13.0 12.9 12.8 188. 125. NT 186. 213 . 274. 187. 183. 102. 168. 16.37 12.57 NT 17.83 14.95 12.84 15.69 13.88 14.13 11.10 163 . 162 . 173. 175. 175. 227. NT 180. 153. 206. 9.76 10.74 9.21 15.30 12.61 19.00 NT 11.14 10.07 11.56 2.62 1.26 NT 2.56 2.05 2.31 2.24 2.09 2.54 1.55 2.05 1.71 2.24 2.91 2.08 1.71 NT 1.36 1.56 1.62 737 Company Sanitized. Does not contain TSCA C 8 t H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number COND RBC x 10a 6/u L HGB g/dL Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR NT NT OK 8.23 14.3 OK 8.33 15.2 OK 7.67 14.2 OK 8.15 15.1 OK 8.27 15.1 OK 9.03 15.9 OK 8.29 15.1 OK 0.29 14.8 OK 8.15 15.0 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 OK 8.64 14.6 OK 7.67 14.0 OK 8.12 14.5 OK 8.04 13.8 OK 8.18 14.5 OK 7.82 14.1 OK 8.20 15.3 OK 8.41 15.2 OK 7.12 12.5 OK 7.70 14.0 Individual Hematology Values HOT MCV MCH MCHC % fL P9 g/dL NT ' 45.1 47.4 44.1 46.1 47.5 51.3 48.8 46.7 47.4 NT 54.8 56.9 57.5 56.5 57.4 56.8 58.8 56.3 58.2 45.6 44.0 46.2 43.7 46.6 45.9 49.1 48.4 40.2 44.2 52.7 57.3 56.9 54.4 57.0 58.7 60.0 57.6 56.4 57.4 NT 17.4 18.2 18.5 18.5 18.2 17.6 18.2 17.9 18.4 16.9 18.2 17.9 17.2 17.8 18.0 18.6 18.0 17.5 18.2 NT 31.7 32.0 32.2 32.8 31.7 31.0 30.9 31.8 31.5 32.1 31.9 31.5 31.6 31.2 30.7 31.1 31.3 31.1 31.8 DuPont-5386 RDW ARET WBC ANEU % x 10a 3/u L xlO*3/uL xl0^3/uL NT 13.4 13.1 12.8 13.5 13.3 13.0 14.0 14.2 13.8 15.0 15.9 15.0 14.1 15.1 17.8 15.9 12.9 14.2 14.9 NT 153. 220. 238. 159. 185. 147. 237. 203. 222. NT 11.07 16.28 11.52 14.98 14.70 11.25 20.47 12.04 14.09 237. 185. 229. 177. 187. 280. 296. 156 . 194 . 240. 14.74 13.94 22.55 17.74 12.04 16.27 15.77 12.07 13.01 14.41 NT 1.66 2.21 2.00 1.69 1.03 0.56 1.23 2.97 2.44 3.10 1.68 3.02 2.70 1.66 2.47 1.26 3.14 2.21 2.17 738 Company Sanitized. Does not contain TSCA CBf ## H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations_________________________________________ Animal Number ANPR x l 0 A3/uL ALYM x 10a 3/u L AMON xlO a 3/u L Individual Hematology Values AEOS ABAS ALUC ABLT x 10a 3/u L x 10a 3/u L xlOA3/uL x 10a 3/u L AMSC x 10a 3/u L PLT Xl0A3/uL Male, Group:: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 0.00 0.00 NT NT NT 0.00 NT NT 0.00 0.00 13.10 10.43 NT 14.20 12.29 10.40 12.36 11.03 11.02 8.99 0.49 0.75 NT 0.69 0.30 0.13 0.55 0.37 0.42 0.33 Male, Group : III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 0.00 NT NT 0.00 NT 0.00' NT NT NT 0.00 7.22 8.43 6.32 11.17 9.78 17.10 NT 9.19 8.03 8.90 0.20 0.35 0.32 0.77 0.38 0.19 NT 0.30 0.24 0.69 0.16 0.13 NT 0.21 0.14 0.00 0.21 0.18 0.14 0.22 0.29 0.10 0.23 0.46 0.13 0.00 NT 0.09 0.12 0.35 0.00 0.00 NT 0.07 0.07 0.00 0.07 0.09 0.00 0.00 0.00 0.05 0.03 0.00 0.07 0.00 NT 0.05 0.04 0.00 0.00 0.00 NT 0.10 0.11 0.00 0.26 0.12 0.00 0.00 0.00 0.11 0.08 0.00 0.18 0.00 NT 0.15 0.09 0.00 0.00 0.00 NT NT NT O.OO NT NT 0.00 0.00 0.00 NT NT 0.00 NT 0.00 NT NT NT 0.00 0.00 0.00 NT NT NT 0.00 NT NT 0.00 0.00 0.00 NT NT 0.00 NT 0.00 NT NT NT 0.00 1251 1145 NT 854 1330 1216 1225 RNV 1227 RNV 925 1160 952 1157 1186 1055 NT 1175 861 1025 # DuPont-5386 t 739 Company sanitized. Does not contain TSCA CB Animal ANPR ALYM Number x 10a 3/u L xlOA3/uL Individual Hematology Values ^AMON AEOS ABAS ALUC ABLT XlO 3/uL xlO 3/uL x 10a 3/u L x 10a 3/u L x 10a 3/u L Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NT NT NT NT 0.00 0.00 NT NT NT NT 9.10 13.09 8.72 12.20 12.64 10.01 18.83 8.43 11.05 NT 0.14 0.51 0.47 0.18 0.74 0.56 0.21 0.25 0.27 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 0.00 NT NT NT NT NT 0.00 0.00 0.00 NT 10.76 11.60 18.36 14.26 9.36 12.81 13.40 8.69 10.28 11.70 0.44 0.28 0.49 0.34 0.34 0.48 0.79 0.24 0.39 0.23 NT 0.05 0.08 0.19 0.32 0.29 0.11 0.21 0.20 0.07 0.44 0.23 0.24 0.21 0.34 0.15 0.32 0.00 0.13 0.08 NT 0.04 0.12 0.05 0.06 0.00 0.00 0.00 0.05 0.05 0.00 0.06 0.10 0.07 0.08 0.08 0.00 0.00 0.00 0.05 NT 0.08 0.27 0.08 0.53 0.00 00.. 0000 00.. 2124 0.00 0.08 0.34 0.15 0.26 0.28 0.00 0.00 0.00 0.18 NT NT NT NT NT 0.00 0.00 0.00 NT NT 0.00 NT NT NT NT NT 00.. 0000 0.00 NT AMSC x 10a 3/u L NT NT NT NT NT 0.00 0.00 0.00 NT NT 0.00 NT NT NT NT NT 0.00 0.00 0.00 NT PLT x 10a 3/u L NT 1037 1272 1172 928 RNV 885 1228 1246 970 RNV 1015 RNV 1245 1047 1177 RNV 1131 1153 1008 SPEC 740 .Company Sanitized. Does not contain TSCA CBI # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO^e/uL HGB g/dL Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 OK 9.18 15.4 OK 8.85 14.8 OK 8.99 15.4 OK 8.87 16.0 OK 8.57 15.3 OK 9.63 16.2 OK 8.42 15.3 OK 8.57 15.5 OK 9.39 16.2 OK 8.84 15.9 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 OK 7.68 OK 8.01 OK 8.09 OK 8.01 OK 8.00 .OK- 7.49 OK 7.94 OK 7.71 OK 8.60 OK 8.17 14.5 14.8 14.0 14.4 14.4 13.5 14.3 13.1 16.2 13.9 Individual Hematology Values pgHCT MCV MCH % fL MCHC g/dL 47.8 46.3 46.4 49.9 47.5 51.0 47.6 47.0 51.0 48.9 44.2 44.4 43.3 44.4 44.3 41.1 44.4 39.7 50.1 42.7 52.0 52.3 51.7 56.3 55.4 52.9 56.6 54.9 54.3 55.3 57.6 55.4 53.5 55.3 55.4 54.9 56.0 51.5 58.2 52.2 16,.8 16,.7 17,,i 18,.0 17,.8 16,.8 18 ,.2 18..1 17..2 17,.9 18.9 18.4 17.3 17.9 18.0 18.1 18.0 17.0 18.8 17.0 32 .3 31,.9 33 ,.1 32,.0 32 ,.2 31..8 32.,2 32..9 31..7 32,.4 32.8 33.2 32.3 32.4 32.6 33.0 32.1 32.9 32.3 32.6 # DuPont-5386 RDW ARET WBC ANEU % X10A3/UL xlO*3/uL xlO*3/uL 14 .5 15 .2 13 .3 12 .6 13..4 12 ,.9 14 .0 13..4 14.,i 12 ,.8 11.5 12.4 12.9 13.4 10.8 14.9 12.3 14.3 11.7 13.1 224. 216. 167. 188. 171. 190. 231. 142. 205. 147. 10 .14 15 .17 10..25 15..43 10..50 22 .,15 12 .,06 11.,33 14 .,34 9..75 132 . 174 . 180. 153 . 132 . 176. 124 . 153 . 119. 159. 14.61 10.52 11.88 16.84 16.97 11.62 8.94 9.06 12.94 18.72 3 .52 2 .88 1,.12 1,.26 0..67 2 ,.67 1..25 2 .34 1..01 1..17 3.29 1.52 1.83 1.08 2.71 2.54 1.06 1.31 1.83 2.18 741 Company Sanitized. Does not contain TSCA C * H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR x l O A3/uL ALYM x 10 A3/uL AMON x 10a 3/u L Individual Hematology Values AEOS x 10a 3/u L ABAS xlOA3/uL ALUC x l O A3/uL ABLT xlOA3/uL AMSC PLT xlOA3/uL xlOa3/u L Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 NT 5 .90 NT 11 .52 NT 8 .71 NT 13 .24 NT 9 .50 NT 17 .83 NT 10 .32 NT 8 .47 NT 12,.48 NT 8 ,.06 0.30 0.38 0.20 0.57 0.11 0.74 0.15 0.26 0.41 0.32 0.17 0.13 0.08 0.16 0.06 0.33 0.10 0.10 0.15 0.07 0.13 0.09 0.05 0.05 0.04 0.09 0.09 0.06 0.07 0.05 0.11 0.17 0.09 0.15 0.11 0.49 0.15 0.10 0.23 0.08 NT NT 1185 NT NT 1154 NT NT 1075 NT NT RNV NT NT 1044 .NT NT 872 NT NT 1172 NT NT 910 NT NT RNV NT NT RNV Male, Group: VII - 250 mg/kg - Day 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 NT 11..05 NT 8..45 NT 9. 41 NT 15. 07 NT 13 .30 NT' 8 .50 NT 7 .47 NT 7 .22 NT 10. 59 NT 15. 13 0.18 0.26 0.24 0.27 0.45 0.25 0.22 0.23 0.20 0.53 0.06 0.09 0.08 0.10 0.19 0.08 0.06 0.11 0.09 0.48 0.08 0.05 0.09 0.12 0.19 0.06 0.04 0.03 0.07 0.10 0.16 0.16 0.22 0.20 0.13 0.19 0.08 0.17 0.15 0.30 NT NT NT NT NT NT NT NT NT NT NT 1058 NT 1167 NT 1181 NT 1016 NT 1099 NT RNV NT 940 NT 1148 NT 1088 NT 1035 DuPont-5386 SPEC 742 Company Sanitized. Does notcontain TSCA CBI H90--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number COND RBC x 10a 6/u L HGB g/dL Female, Group: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 OK 8.16 15.4 OK 8.39 15.4 OK 8.32 16.2 OK 8.39 15.3 OK 7.85 14.8 OK 8.32 16.2 OK 8.26 15.4 OK 8.12 15.1 OK 8.41 15.0 OK 8.37 15.4 Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR OK OK OK OK OK' OK OK OK OK NT 7.34 7.89 7.65 7.81 8.35 8.24 7.70 7.86 7.85 NT 14.6 14.9 14.8 14.6 15.4 14.8 14.4 14.7 14.9 Individual Hematology Values pgHCT MCV MCH % fL MCHC g/dL 46.2 48.3 47.4 46.3 45.0 48.5 46.6 47.5 47.1 46.0 NT 44.6 44.9 44.0 43.9 49.0 46.2 43.7 44.4 43.3 56.6 57.5 57.0 55.2 57.4 58.3 56.4 58.5 56.0 55.0 NT 60.7 57.0 57.6 56.2 58.7 56.1 56.8 56.5 55.1 18.9 18.4 19.4 18.2 18.9 19.5 18.6 18.6 17.8 18.5 NT 20.1 18.8 19.3 18.7 18.5 18.0 18.7 18.7 19.0 33.4 32.0 34.1 33.0 33.0 33.4 33.0 31.9 31.8 33.6 NT 33.2 33.1 33.6 33.2 31.4 32.0 33.0 33.2 34.5 DuPont-5386 RDW ARET WBC ANEU % xlO~3/uL xlOA3/uL xlO"3/uL 11.7 12.2 11.2 12.0 11.1 12.2 11.3 11.5 12.4 11.6 NT 12.1 11.4 11.8 11.9 12.6 11.4 12.6 11.4 11.8 220. 222 . 198. 217. 199. 226. 148. 208 . 240. 203 . 12.21 15.77 10.57 9.80 12.17 16.31 12.64 18.68 11.02 17.52 NT 251. 173 . 194 . 225. 265. 196. 248 . 168 . 228 . NT 11.44 15.43 9.71 10.05 15.67 14.41 17.08 8.74 12.93 2.01 2.02 1.43 0.92 1.32 1.82 2.11 3.08 0.71 2.25 NT 0.78 1.71 1.81 2.00 1.25 1.85 2.31 1.14 1.76 743 Company Saniitlzed. Doesnoicorta TSCACa H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number COND RBC x l O A6/uL HGG g/dL Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 OK 7.93 14.9 OK 8.68 15.5 OK 7.86 14.9 OK 8.38 15.1 OK 9.03 15.9 OK 7.88 15.1 OK 7.65 14.9 OK 8.37 15.3 OK 7.85 14.5 OK 7.76 14.5 Female, Group : VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 OK 7.38 OK 7.72 OK 7.00 OK 7.58 OK 8.61 OK" 7.84 OK 7.97 OK 7.62 OK 8.25 OK 7.56 14.0 15.3 13.1 14.1 15.0 15.2 14.7 14.3 14.7 14.5 Individual Hematology Values HCT MCV MCH MCHC % fL P9 g/dL 45.5 46.5 45.2 46.3 48.8 46.0 43.7 46.4 42.9 44.2 42.4 45.1 40.1 43.3 46.9 45.3 44.5 43.6 47.3 44.0 57.4 53.6 57.4 55.2 54.1 58.3 57.1 55.4 54.7 56.9 57.5 58.4 57.3 57.1 54.5 57.8 55.8 57.3 57.3 58.2 18.7 17.8 18.9 18.0 17.6 19.2 19.5 18.3 18.4 18.7 18.9 19.8 18.7 18.6 17.4 19.4 18.5 18.8 17.8 19.2 32.6 33.3 33.0 32.6 32.6 32.8 34.1 33.0 33.7 32.8 32.9 33.9 32.6 32.5 31.9 33.6 33.1 32.8 31.0 32.9 DuPont-5386 RDW ARET WBC ANEU % xlO"*3/uL xlOA3/uL x 10a 3/u L 11.5 11.7 12.4 11.2 11.9 11.9 10.8 11.3 11.4 13.3 12.0 12.4 12.4 12.6 12.0 11.6 11.6 12.0 12.7 12.2 203. 197. 229. 179. 198. 239. 146. 156. 192 . 267. 10.40 16.42 12.35 12.34 13.56 8.85 14.80 18.99 15.81 10.69 177 . 263 . 223. 191. 249. 189. 174 . 247. 241. 150 . 11.54 16.07 13.91 11.60 11.27 14.20 16.91 12.61 14.72 13.09 1.68 2.00 1.09 1.66 2.15 0.43 2.06 2.14 1.93 1.72 1.47 2.34 2.03 1.17 2.45 1.41 3.13 1.03 1.34 1.75 744 Company Sanitized. Docs not contain TSCA C8f +# H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlO^ 3 / u h ALYM xlO*3/uL AMON XlO A3/uL Individual Hematology Values AEOS ABAS ALUC ABLT x 10a 3/u L x 10a 3/u L x 10a 3/u L x 10a 3/u L AMSC x 10a 3/u L PLT x 10a 3/u L Female, Group : IX - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NT 9.36 NT 12.77 NT 8.39 NT 8.37 NT 10.25 NT 13.33 NT 9.76 NT 14.71 NT 9.76 NT 14.31 0.21 0.29 0.32 0.29 0.33 0.44 0.20 0.41 0.18 0.32 Female, Group : IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT NT NT NT NT 0.00' NT NT NT NT NT 9.55 12.94 7.20 7.56 14.26 11.67 14.03 7.08 10.38 NT 0.16 0.33 0.26 0.22 0.16 0.40 0.28 0.23 0.24 0.33 0.24 0.19 0.11 0.10 0.23 0.24 0.15 0.16 0.16 NT 0.16 0.17 0.12 0.06 0.00 0.07 0.10 0.10 0.15 0.06 0.16 0.06 0.02 0.06 0.19 0.07 0.11 0.07 0.22 NT 0.12 0.11 0.09 0.09 0.00 0.15 0.11 0.04 0.13 0.24 0.29 0.17 0.09 0.11 0.30 0.26 0.22 0.14 0.27 NT 0.67 0.16 0.23 0.12 0.00 0.27 0.25 0.15 0.27 NT NT NT NT NT -NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 0.00 NT NT NT NT 1173 1158 1060 1339 1092 RNV 1294 RNV RNV RNV NT 990 1090 878 1171 953 1514 994 903 1239 DuPont-5386 745 Company Sanitized. Does not contain TSCA Cffli # 4P H90--2D45ay16G: aSvaugbechSrtouadiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number ANPR xl0A3/uL ALYM xlOa 3/u L AMON xlOa 3/u L Individual Hematology Values AEOS ABAS ALUC ABLT xlOA3/uL xl0A3/uL xl0A3/uL x 10a 3/u L AMSC xlOa 3/u L PLT x 10a 3/u L Female, Group : VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NT 8.05 NT 13.25 NT 10.39 NT 9.77 NT 10.59 NT 7.99 NT 11.96 NT 15.65 NT 13.16 NT 8.26 0.31 0.40 0.25 0.32 0.32 0.14 0.40 0.40 0.25 0.30 Female, Group : VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NT 9.51 NT 12.93 NT 10.89 NT 9.62 NT 7.93 NT 12.10 `NT 12.92 NT 10.81 NT 12.63 NT 10.54 0.17 0.39 0.44 0.41 0.34 0.22 0.28 0.21 0.17 0.29 0.13 0.36 0.08 0.26 0.18 0.10 0.19 0.22 0.19 0.10 0.16 0.13 0.21 0.13 0.16 0.22 0.21 0.14 0.18 0.23 0.05 0.14 0.18 0.13 0.14 0.05 0.06 0.19 0.09 0.11 0.08 0.12 0.08 0.07 0.11 0.08 0.12 0.15 0.10 0.07 0.17 0.26 0.36 0.21 0.17 0.14 0.13 0.38 0.19 0.20 0.13 0.16 0.28 0.21 0.28 0.16 0.25 0.26 0.29 0.21 NT NT NT NT NT .NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 1098 NT 1100 NT 1047 NT 1253 NT 867 NT RNV NT RNV NT 1147 NT 1076 NT 1083 NT 1141 NT 1019 NT RNV NT 1143 NT 1157 NT 955 NT 999 NT 1090 NT 894 NT 1211 DuPont-5386 746 San^.Doesno.oon.ainTSCAC Company *m H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________ # DuPont-5386 Animal Number COND RBC x 10a 6/u L HGB g/dL Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 OK 8.56 16.1 OK 8.45 15.5 OK 7.90 15.1 OK 8.00 14.4 OK 8.39 15.8 OK 8.34 15.8 OK 8.53 15.8 OK 8.73 15.9 OK 8.46 15.1 OK 8.71 15.9 Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR OK OK OK OK OK' K OK OK OK NT 7.78 8.31 8.16 7.84 8.66 8.02 7.85 7.96 8.15 NT 15.4 16.4 15.3 14.7 15.6 14.5 14.6 15.2 14.7 Individual Hematology Values pgHCT MCV MCH % fL MCHC g/dL 48.0 47.5 45.2 43.8 49.5 48.8 49.4 48.7 46.6 48.8 NT 46.6 45.2 46.8 44.7 50.2 45.0 43.4 45.5 44.0 56.0 56.2 57.3 54.7 59.1 58.5 57.9 55.7 55.0 56.0 NT 59.9 54.4 57.4 57.0 58.0 56.1 55.3 57.1 54.0 18.8 18.4 19.1 18.1 18.9 19.0 18.5 18.2 17.9 18.2 NT 19.9 19.7 18.8 18.7 18.1 18.1 18.6 19.1 18.0 33.6 32.8 33.4 33.0 31.9 32.5 32.0 32.7 32.5 32.5 NT 33.2 36.3 32.7 32.8 31.2 32.3 33.6 33.4 33.4 RDW ARET WBC ANEU % x 10a 3/u L xlO~3/uL x 10a 3/u L 11.1 11.8 11.0 11.6 10.7 11.8 11.3 11.2 11.8 10.2 NT 11.1 10.7 11.5 11.2 11.9 10.9 11.2 11.7 11.5 115. 180. 144 . 144 . 207. 166. 148. 147. 174 . 80. 10.38 11.59 7.82 6.65 9.21 11.70 9.64 11.28 10.60 10.71 NT 188. 121. 127. 116. 173 . 117. 173. 201. 193. NT 9.38 8.88 8.05 8.47 11.66 9.72 12.64 8.03 11.89 1.21 1.31 1.40 0.67 1.32 1.09 1.32 1.62 0.93 0.64 NT 0.68 2.08 1.56 1.47 0.83 1.75 1.64 1.10 1.99 747 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number COND RBC xlO^e/uL HGB g/dL Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 OK 7.87 14.7 OK 7.18 14.5 OK 7.94 14.7 OK 8.51 15.2 OK 9.48 16.3 OK 7.81 14.7 OK 7.74 14.9 OK 8.41 15.2 OK 8.56 15.3 OK 8.16 15.0 Female, Group : VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 OK NSR OK OK OK OK' OK OK OK OK 7.30 NT 7.78 8.02 8.19 7.66 8.13 8.16 7.61 7.50 13.6 NT 14.1 14.6 14.3 14.4 14.6 14.9 13.4 13.9 Individual Hematology Values HCT MCV MCH % fL pg MCHC g/dL 45.3' 48.6 44.7 46.6 51.5 43.6 44.0 46.4 46.6 45.1 42.2 NT 44.4 44.7 45.1 43.7 45.4 46.1 41.6 43.0 57.5 67.6 56.3 54.8 54.3 55.9 56.8 55.1 54.5 55.3 . 18.6 20.2 18.5 17.9 17.2 18.9 19.2 18.0 17.9 18.4 57.8 NT 57.2 55.7 55.1 57.0 55.8 56.5 54.7 57.3 18.7 NT 18.2 18.2 17.5 18.8 17.9 18.3 17.6 18.5 32.4 29.8 32.8 32.6 31.7 33.8 33.8 32.7 32.9 33.2 32.3 NT 31.8 32.6 31.8 32.9 32.1 32.4 32.1 32.4 DuPont-5386 RDW ARET WBC % Xl0~3/uL Xl0^3/uL ANEU 3/uL 11.9 19.2 11.6 11.0 11.4 11.7 11.0 11.3 11.0 12.4 12.5 NT 12.5 12.6 14.8 11.5 11.4 11.5 11.9 12.1 173 . 725. 171. 122. 161. 206. 145. 119. 150. 220. 7.40 12.84 10.55 7.91 7.57 9.24 10.05 12.36 13.02 12.67 161. NT 197. 157. 229. 165. 155. 187. 140. 156. 8.68 NT 10.17 11.50 7.74 12.72 12.43 8.44 12.97 9.89 2.74 2.12 2.05 1.25 2.13 1.99 3.71 1.80 1.22 4.04 1.01 NT 1.73 2.07 1.66 1.55 3.41 0.69 1.49 1.25 748 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number ANPR xlO|A3/uL ALYM x 10a 3/u L AMON XlO a 3/u L Individual Hematology Values AEOS ABAS ALUC ABLT xlOA3/uL xl0A3/uL xl0^3/uL xl0^3/uL AMSC xlO*3/uL PLT xlOA3/uL Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NT 8.38 0.19 NT 9.60 0.18 NT 5.97 0.26 NT 5.55 0.19 NT 7.47 0.19 NT 9.69 0.38 NT 7.82 0.19 NT 9.06 0.19 NT 9.14 0.19 NT 9.53 0.15 Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT NT NT 8.15 NT 6.26 NT 5.91 NT 6.63 NT' 9.85 NT 7.34 NT 10.54 NT 6.49 NT 9.26 NT 0.13 0.23 0.27 0.19 0.45 0.30 0.17 0.16 0.23 0.40 0.26 0.11 0.13 0.09 0.22 0.14 0.15 0.18 0.14 NT 0.16 0.23 0.14 0.06 0.14 0.07 0.12 0.16 0.21 0.07 0.10 0.04 0.06 0.06 0.09 0.06 0.12 0.06 0.09 NT 0.12 0.03 0.07 0.03 0.07 0.12 0.08 0.04 0.11 0.12 0.14 0.05 0.05 0.08 0.23 0.11 0.13 0.09 0.16 NT 0.15 0.06 0.10 0.09 0.31 0.15 0.09 0.08 0.09 NT NT NT NT NT .N T NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 1044 NT 1047 NT 1052 NT 1320 NT 967 NT 1054 NT 1129 NT 979 NT 787 NT 867 NT NT NT 958 NT RNV NT 872 NT 1159 NT 861 NT 1077 NT 1034 NT 1054 NT 1018 DuPont-5386 SPEC 749 Company Sanitized. Does not contain TSCA Cttf ## H90--2D4a5y16G:avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations_____________________ Animal Number ANPR xlO*3/uL ALYM xl0A3/uL AMON x l 0 A3/uL Individual Hematology Values AEOS ABAS ALUC ABLT xl0A3/uL xl0^3/uL xl0^3/uL xlOA3/uL AMSC xlOA3/uL PLT x !0a 3/u L Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NT 4.28 0.15 0.14 0.05 0.04 NT NT RNV NT 9.80 0.32 0.40 0.06 0.14 NT NT RNV NT 7.96 0.22 0.10 0.10 0.12 NT NT 1083 NT 6.03 0.22 0.23 0.07 0.12 NT NT 1134 NT 4.92 0.22 0.20 0.04 0.06 NT NT RNV NT 6.58 0.23 0.26 0.10 0.08 .NT NT 1132 NT 5.72 0.20 0.32 0.04 0.07 NT NT RNV NT 9.65 0.38 0.18 0.10 0.25 NT NT 1060 NT 11.24 0.24 0.12 0.09 0.11 NT NT 1305 NT 7.71 0.40 0.23 0.09 0.20 NT NT 996 Female, Group : VIII - 250 mg/kg - Day 93 643332 NT 7.35 0.14 0.08 0.05 0.06 NT NT 1045 643340 NT NT NT NT NT NT NT NT NT 643341 NT 7.71 0.35 0.26 0.04 0.08 NT NT 1143 643359 NT 8.24 0.69 0.16 0.05 0.29 NT NT 904 643370 NT 5.56 0.17 0.25 0.02 0.09 NT NT RNV 643404 NT' 10.58 0.25 0.16 0.05 0.13 NT NT RNV 643408 NT 8.31 0.32 0.20 0.06 0.12 NT NT 1000 643435 NT 7.23 0.21 0.15 0.03 0.12 NT NT RNV 643446 NT 10.90 0.16 0.16 0.12 0.14 NT NT 849 643466 NT 7.86 0.29 0.24 0.04 0.20 NT NT 1231 # DuPont-5386 750 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number COND RBC XlOA6/uL HGB g/dL Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 OK NSR OK OK OK OK OK OK OK OK 7.97 NT 7.80 8.33 7.87 7.57 8.00 7.28 8.49 8.25 14.9 NT 14.9 15.7 15.2 14.4 15.3 14.0 15.9 16.0 Female, Group : VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 OK OK OK OK OK CLOT OK OK OK OK 7.91 7.83 8.10 8.58 7.12 NT 8.58 7.38 8.34 8.13 14.6 14.1 15.5 14.9 14.0 NT 15.7 13.5 15.6 15.4 Individual Hematology Values HCT MCV % fL MCH MCHC pg g/dL 45.3 NT 44.6 47.0 48.2 43.6 46.4 42.0 47.9 46.3 44.0 43.0 46.6 44.6 42.2 NT 47.3 39.9 45.3 46.1 56.8 NT 57.2 56.4 61.2 57.7 58.0 57.6 56.5 56.1 55.6 54.9 57.6 52.0 59.2 NT 55.1 54.1 54.3 56.6 18.7 NT 19.2 18.8 19.4 19.1 19.1 19.3 18.7 19.4 18.4 18.0 19.1 17.3 19.6 NT 18.3 18.3 18.8 19.0 33.0 NT 33.5 33.3 31.6 33.0 33.0 33.5 33.1 34.5 33.1 32.7 33.1 33 .4 33.2 NT 33.1 33.7 34.5 33.5 RDW ARET WBC ANEU % xlOA3/uL x 10a 3/u L x 10a 3/u L 13.3 NT 12.6 12.6 12.5 12.8 12.3 12.8 11.3 11.2 11.5 11.8 11.8 11.9 11.7 NT 12.0 11.8 11.9 11.0 157. NT 206 . 174 . 179. 162. 205. 178. 133. 148 . 7.17 NT 6.44 6.91 10.41 7.69 7.19 6.53 8.04 11.41 106. 145. 159 . 149. 235. NT 152. 120. 130 . 110. 6.94 8.55 8.95 6.44 11.22 NT 8.02 8.59 7.70 6.63 1.08 NT 1.31 0.70 0.84 1.61 1.34 1.04 1.11 1.10 1.50 1.07 1.55 0.90 1.31 NT 2.48 2.24 1.95 1.25 Company Sanitized. Does notcontain TSCACBf ## H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number ANPR xlO a 3/u L ALYM x 10a 3/u L AMON x 10a 3/u L Individual Hematology Values AEOS ABAS ALUC ABLT x 10a 3/u L Xl0A3/uL x 10a 3/u L x 10a 3/u L AMSC x 10a 3/u L PUT x 10a 3/u L Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 6434X5 643425 643426 643448 643453 NT 5.80 0.12 NT NT NT NT 4.62 0.20 NT 5.88 0.14 NT 9.04 0.30 NT 5.55 0.27 NT 5.45 0.15 NT 5.07 0.25 NT 6.52 0.17 NT 9.72 0.31 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 NT 4.95 NT 7.08 NT 6.95 NT 4.94 NT* 9.16 NT NT NT 4.58 NT 5.72 NT 5.24 NT 4.88 0.20 0.16 0.14 0.26 0.43 NT 0.58 0.30 0.27 0.23 0.09 NT 0.12 0.06 0.07 0.16 0.10 0.05 0.06 0.16 0.10 0.11 0.21 0.14 0.16 NT 0.17 0.16 0.15 0.17 0.01 NT 0.06 0.03 0.02 0.04 0.07 0.03 0.10 0.04 0.05 0.06 0.03 0.02 0.03 NT 0.02 0.07 0.03 0.01 0.06 NT 0.13 0.08 0.14 0.06 0.09 0.08 0.08 0.09 0.13 0.07 0.08 0.18 0.12 NT 0.19 0.09 0.08 0.09 NT NT NT NT NT .NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT NT 958 NT NT NT 985 NT 1376 NT 1158 NT 1256 NT 797 NT 1050 NT 1128 NT 682 NT 1212 NT 1431 NT RNV NT RNV NT RNV NT NT NT 1088 NT 1034 NT RNV NT 1095 # DuPont-5386 752 Company Sanitized. Does not contain TSCA CB H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 ' 23 11 11 11 12 14 1 '3 13 11 12 13 11 11 11 12 13 13 13 1 1 22 ACAN 1 1 1 2 2 3 2 2 1 1 1 1 2 1 2 2 2 2 1 2 TARO DuPont-5386 RX HJB 753 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 -- 1 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 -- 1 1 1 ACAN DuPont-5386 HJB 754 Company Sanitized. Does not contain TSCA CBl  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations____________ ______________________ ____________________DuPont-5386 Animal Number SPEC Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 Individual Red Blood Cell Morphology Values 755 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 1-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 Individual Red Blood Cell Morphology Values DuPont-5386 756 Company Santf'Ted. Does not conta'nTSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - 0 mg/kg - Day 91 643143 -- -- -- 643150 -- 1 -- 3 1 -- 2 643185 643189 643204 __ 11 1 -- 3 1 -- 3 643205 32 643235 -- _ _ -- 643241 1 1 2 -- .3 1 -- 3 1 1 -- 3 643288 13 643300 -~ 1 3 Male, Group: III - 25 mg/kg - Day 91 643173 -- 643179 643180 643228 643240 643264 643272 643290 __ 643292 -- 643308 -- -"-" "- 1 -1 -1 -1 -1 -2 -- 1 -1 -1 -- 3 1 3 3 3 3 3 3 2 ACAN 3 1 3 3 4 3 3 3 2 1 1 2 3 2 3 3 3 3 TARG DuPont-5386 RX HJB CompanSaniUd. Does notcontainTSCACBI #' # # H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations_____________________________________________________ __D__u_P_o_n_t-_5_3_8_ Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: V - 100 mg/kg - Day 91 643175 -- 643224 -- -- 643243 -- 643247 -- 643250 643257 -- 643275 643311 -- 643314 643318 -" Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 -- -- __ -- -- ------ 2 2 1 2 2 1 "" -" -" " -" """ 1 -** 1 1 -2 1 -1 "~ 3 3 21 .3 1 3 3 3 3 2 3 2 2 3 2 3 2 3 ACAN 3 3 2 3 1 3 3 3 3 3 3 3 3 3 3 3 3 3 TARG RX HJB 758 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 1-POIKILOCYTOSIS 1-HEMOGLOBIN CRYSTAL 1-SPHEROCYTE Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 1-POIKILOCYTOSIS Individual Red Blood Cell Morphology Values DuPont-5386 759 Company Sanitized. Does not contain TSCA CSf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 1-POIKILOCYTOSIS Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 1-POIKILOCYTOSIS 1-POIKILOCYTOSIS 1-POIKILOCYTOSIS Individual Red Blood Cell Morphology Values DuPont-5386 760 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Male, Group: I - 0 mg/kg - Day 125 643162 643172 -* " 11 643195 -- 643226 -- 1 1 643237 -- 1 1 643246 -- 11 643253 11 643262 643303 "" 11 643304 -- Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 11 11 21 11 11 1 .1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 11 1 1 11 1 1 1 1 1 2 2 1 1 1 1 1 2 1 1 1 2 2 ACAN 1 2 1 1 1 3 1 1 1 1 3 1 3 1 3 1 2 TARO DuPont-5386 RX HJB 761 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 1-SPHEROCYTE Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 1 -POI'KILOCYTOSIS Individual Red Blood Cell Morphology Values DuPont-5386 762 Company S a n itiz e d . Does not contain tscacbi H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 -- 1 Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 ACAN TARG DuPont-5386 RX HJB 763. Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 -- Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 -- 1 1 1 1 __ 1 1 1 1 1 1 1 1 1 __ __ 1 1 1 1 __ 1 1 1 3 2 1 2 2 -4 3 3 2 3 1 2 3 2 3 3 3 3 4 3 ACAN 1 1 2 2 2 2 1 2 1 1 1 2 1 2 3 1 2 1 TARG ------- 2 .. ------ ---- DuPont-5386 RX --- ---- ~- -- -- __ -- -- ~-- -- _-" -- "~ -- -- ~" 764 Company Sanitized. Does not contain TSCA CBI ## H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Female, Group: II - 0 mg/kg - Day 45 643354 643362 643361 643374 643398 643406 643436 643463 643477 643486 2-HEMOGLOBIN CRYSTAL Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 1-HEMOGLOBIN CRYSTAL Individual Red Blood Cell Morphology Values # DuPont-5386 765 Company Sanitized. Does not contain TSCA CBI H90--2D45a1y6G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643469 2-HEMOGLOBIN CRYSTAL 1-HEMOGLOBIN CRYSTAL 2-HEMOGLOBIN CRYSTAL Female, Group: VIII - 250 mg/kg - Day 45 43332 643340 643341 643359 643370 643404 643408 643435 643446 643466 1-IEMOGLOBIN CRYSTAL DuPont-5386 766 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 93 643354 -- 643361 -- -- 643362 -- -- 643374 -- 643398 -- 643406 -- -- 643436 -- 643463 643477 643486 Female, Group : IV - 25 mg/kg * ] 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 -- -- -- -- ---- ---- --- --- ACAN DuPont-5386 HJB 767 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: VI - 100 mg/kg - Day 93 643322 -- 643323 -- 1 1 643366 -- -- 643367 643392 -- ~ 643409 643461 -- -- 643462 -- 643472 -- 643489 -- Female, Group : VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 -- --- . ---- -- -- -- -- -" ---"--- "- 1 2 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 ACAN TARG DuPont-5386 RX HJB 768 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtpundiyc iTnoRxiatistywith One-Generation Reproductive Evaluations Animal Number SPEC Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 1-POIKlLOCYTOSIS Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 Individual Red Blood Cell Morphology Values DuPont-5386 Company Sanitized. Does not contain TSCA CBl #0 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 '' 1-S PHEROCYTE # DuPont-5386 770 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM ANIS Individual Red Blood Cell Morphology Values MIC MAC POLY HYPO ECHI Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 1I Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 ACAN TARG DuPont-5386 RX HJB 771 Company Sanitized. Does not contain TSCA CBI  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SPEC Individual Red Blood Cell Morphology Values Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 -- DuPont-5386 772 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NORMAL NORMAL NORMAL -NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL ---- ---- Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL NORMAL -- --"" -"" -- -- "- "" "" "" ""-" 1 "- -- "" -~ "" "" 1 DuPont-5386 SPEC DECR PLATELET ADEQ PLATELET 773 Company Sanitized. Does no!confa'n TSCA CBl H90--2D45a1y6G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: V - 100 mg/kg - Day 44 643175 NORMAL -- -- -- 643224 NORMAL -- "- 643243 __ -- -- 1 643247 -- "- 1 643250 NORMAL -* -- 643257 NORMAL -- "" 643275 NORMAL -- -- -" 643311 NORMAL __ -- -" 643314 NORMAL -- "" 643318 NORMAL -" Male, Group: 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 VII - 250 __ NORMAL NORMAL NORMAL NORMAL - -- NORMAL NORMAL NORMAL NORMAL mg/kg - Day 44 ---- -* __ -- *--- , 1 "" "" -- 1 "- -"- "" "" -" "-- DuPont-5386 SPEC UTD PLATELET DECR PLATELET DECR PLATELET UTD PLATELET 774 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: I - 0 mg/kg - Day 91 643143 NORMAL -- -- -- -- -- -- -- 643150 NORMAL -- -- -- "- 643185 -- -- -- "" 643189 NORMAL -- -- -- -- 643204 NORMAL -- -- -- -" ~* -- 643205 NORMAL -- -- -- -- "" 643235 NORMAL -- -- -- -- 643241 __ -- -- 1 -- "- 643288 NORMAL -- -- -~ -" 643300 -- 1 -_ Male, Group : III - 25 mg/kg - Day 91 643173 NORMAL -- -- -- -- -- -- -- 643179 NORMAL -- -- -- ~~ 643180 NORMAL -- "" -- -- 643228 NORMAL -- -- -- *" -- "- 643240 NORMAL "" "- -~ 643264 NORMAL -- -- -- 643272 -- -- -- -- -~ 643290 NORMAL -- -- -~ " 643292 NORMAL -- -- -~ 643308 NORMAL -- " -- SPEC UTD PLATELET DECR PLATELET 775 Company Sanitized. Does not contain tsca cbi H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: V - 100 m g / k g - Day 91 643175 643224 NORMAL -- -- -- "" _- 643243 NORMAL -- -- "- "-- 643247 NORMAL -- -- -- 643250 NORMAL -- -- -- -" "" 643257 -- -- -- 1 "- "" 643275 NORMAL -" 643311 NORMAL -- -- -- -- "- -- "" 643314 NORMAL -- -- -- -~ "" 643318 NORMAL -" Male, Group: VII - 250 mg/kg - Day 91 643174 1 _ _ __ 643193 NORMAL -" "" -- 643194 -- -- -- 1 "- "" 643201 NORMAL -- -" 643215 NORMAL . -- _ - "" 643252 NORMAL -- "" "" 643259 -- -- 1 643260 NORMAL -- -- "- 643298 NORMAL -- -- "- 643315 NORMAL -- SPEC DECR PLATELET DECR PLATELET UTD PLATELET DECR PLATELET 776 Company Sanitized. Does not contain TSCA CBi H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Male, Group: I - 0 mg/kg - Day 125 643162 NORMAL -- -- -- 643172 NORMAL -- -- -- 643195 NORMAL -- -- -- -- 643226 -- -- 1 -- -- -- -- 643237 NORMAL -- -- -- -- -- -- -- 643246 NORMAL -- -- -- -- 643253 NORMAL -- -- 643262 NORMAL -- -- -- -- 643303 1 643304 -- -- 1 -- Male, Group: VII - 250 mg/kg - Day 125 643151 NORMAL -- -- -- -- -- -- -- 643165 NORMAL -- -- -- -- -- 643220 NORMAL -- -- -- 643225 NORMAL -- -- -- 643234 643236 NORMAL __ -- 1 -- -- -- -- 643258 NORMAL -- -- -- -- -- 643266 NORMAL -- -- -- 643296 NORMAL -- -- 643316 NORMAL -- -- -- -- SPEC ADEQ PLATELET UTD PLATELET DECR PLATELET ADEQ PLATELET 777 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX Female, Group:: II - 0 mg/kg - Day 45 643354 NORMAL 643361 NORMAL "" -- 643362 NORMAL -- -- -- 643374 NORMAL -- -- 643398 NORMAL -- -" 643406 -- -- -- 1 643436 NORMAL -- -- -- 643463 -- -- -- 1 -- -- -" 643477 -- 1 -~ 643486 -- 1 "" Female, Group : IV - 25 mg/kg - Day 45 643321 643324 NORMAL 643364 NORMAL -- -- -- -" "- "" 643380 NORMAL -- -- -- "" 643389 643390 643396 643410 NORMAL . NORMAL NORMAL NORMAL --- -- ~" -" """ 643433 NORMAL 643458 NORMAL -- DuPont-5386 SPEC ADEQ PLATELET UTD PLATELET DECR PLATELET ADEQ PLATELET 778. Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group: VI - 100 mg/kg - Day 45 643322 NORMAL -- -- -- -- "* " 643323 NORMAL -- -- "- ~* 643366 NORMAL -- -- -- 643367 NORMAL -- -- -- ~- -- 643392 643409 NORMAL --- l -- -- -- -~ 643461 -- 1 -- -~ - 643462 643472 NORMAL NORMAL -- "-- "~ -- 643489 NORMAL -- " Female, Group : VIII - 250 mg/kg - Day 45 643332 NORMAL __ -- -- -- -- -- 643340 NORMAL -- -- - 643341 -- -- 1 -- -- *~ 643359 NORMAL -- -- -- -- -- -- 643370 NORMAL . -- -- -- -* 643404 NORMAL -- -- 643408 NORMAL -- -- -- -- 643435 NORMAL -- -- -- -- 643446 NORMAL -- -- -- 643466 NORMAL -- -- --~ ~- SPEC ADEQ PLATELET ADEQ PLATELET ADEQ PLATELET 779 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations_________________________ Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group : II - 0 mg/kg Day 93 643354 NORMAL -- -- -- -- -- -- 643361 NORMAL -- -- -- -- _ _ -- - - 643362 NORMAL -- -- -- -- -- -- - - 643374 NORMAL -- -- -- -- -- 643398 NORMAL -- -- -- -- 643406 NORMAL -- -- -- -- r- - - 643436 NORMAL -- -- -- -- -- -- 643463 NORMAL -- -- __ -- -- -- -- 643477 NORMAL -- -- -- -- -- - - 643486 NORMAL -- -- -- -- -- -- Female, Group : IV - 25 mg/kg - Day 93 643321 _ _ _ _ _ _ __ __ 643324 NORMAL -- -- -- -- -- -- 643364 -- -- -- 1 -- -- 643380 NORMAL -- -- -- -- -- 643389 NORMAL -- -- -- -- -- 643390 NORMAL -- -- -- -- -- 643396 NORMAL -- -- 643410 NORMAL -- -- -- -- -- -- 643433 NORMAL -- -- -- 643458 NORMAL -- -- -- -- -- ----- -- DuPont-5386 SPEC UTD PLATELET 780 COmpa" y Sani,b '- Dow not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM Individual white Blood Cell / Platelet Morphology Values DB PC GP BP TOX VC Female, Group: VI - 100 mg/kg - Day 93 643322 -- -- -- 643323 -- 643366 NORMAL -- 643367 NORMAL -- -- 643392 -- 643409 NORMAL -- 643461 -- 643462 NORMAL 643472 NORMAL 643489 NORMAL -- -" Female, Group : VIII - 250 mg/kg - Day 93 643332 NORMAL -- -- 643340 -- 643341 NORMAL -- 643359 NORMAL -- 643370 -- -- 643404 -- -- 643408 NORMAL -- -- 643435 -- -- 643446 NORMAL -- 643466 NORMAL -- 1 1 -1 1 -" --- 1 1 1 DuPont-5386 SPEC UTD PLATELET UTD PLATELET UTD PLATELET UTD PLATELET UTD PLATELET ADEQ PLATELET UTD PLATELET 781 Con'Pany Sanitized. Does no!contain TSCAm i H90--2D45a1y6G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number NORM Individual White Blood Cell / Platelet Morphology Values SM DB PC GP BP TOX VC Female, Group: II - 0 mg/kg - Day 125 643330 NORMAL -- 643336 -- -- -- 643377 NORMAL -- -- 643387 NORMAL 643405 NORMAL 643415 NORMAL -- 643425 NORMAL -- 643426 NORMAL 643448 NORMAL 643453 NORMAL -" Female, Group : VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 NORMAL NORMAL *- . NORMAL NORMAL NORMAL -- -------- ---- -- "- _- -"" "- ~-- -- -~- _~1 -" 1 "" 1 ""- ~- -" 1 "" "" DuPont-5386 SPEC DECR PLATELET DECR PLATELET UTD PLATELET UTD PLATELET 782 Company Sanitized. Does not contain TSCA CBI  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT Male, Group : I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec 14.7 15.6 15.2 16.2 15.7 14.4 14.6 15.1 14.3 16.5 14.8 14.5 15.2 14.3 14.6 14.8 14.5 15.3 14.5 14.1 17.5 17.9 16.8 21.9 18.0 15.0 20.2 22.7 16.5 20.0 13.6 13.1 19.4 17.0 18.4 15.7 16.3 18.7 14.3 16.1 DuPont-5386 783 , Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE NONE NONE NONE . TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec NT 14.7 14.3 14.7 16.6 15.2 16.5 15.5 15.0 14.1 15.6 15.2 14.7 15.0 16.7 15.8 15.5 16.4 14.9 14.9 NT 14.5 13.5 15.7 18.7 13.2 18.7 15.7 17.5 14.8 18.6 17.3 16.1 17.0 16.4 17.4 16.2 16.2 16.0 16.4 DuPont-5386 784 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT Female, Group: XI - 0 mg/kg - Day 93 6433S4 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE SMALL NONE NONE NONE NONE TRACE NONE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE TRACE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec 14.7 NT 14.2 13.4 14.8 14.9 13.9 13.7 15.0 16.0 NT 14.2 14.3 14.3 14.7 14.0 14.0 14.4 14.7 14.8 17.9 NT 16.6 15.0 17.8 16.5 15.9 16.3 18.2 19.6 NT 16.6 15.9 12.9 15.9 17.1 17.7 15.3 14.8 16.3 DuPont-5386 785 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PHEM PLIP PICT Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE TRACE NONE NONE NONE NONE Individual Coagulation Values PT APTT sec sec 13.8 14.4 14.1 14.7 14.6 15.3 14.4 15.2 13.6 14.5 13.7 NT 13.9 14.1 13.4 14.0 13.6 14.6 15.0 14.6 13.8 17.3 17.3 17.1 14.4 15.9 14.3 14.3 17.1 12.9 14.7 NT 15.3 16.2 14.6 14.1 16.7 13.7 12.8 17.5 DuPont-5386 786 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 TRACE SMALL NONE NONE NONE SMALL TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 97 84 82 79 69 70 66 71 74 90 72 81 71 104 79 94 90 74 70 100 37 33 28 27 30 31 23 30 28 31 40 31 33 24 32 26 36 35 38 34 787 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 13.3 19.4 17.3 26.0 20.3 15.6 15.4 25.0 15.6 20.0 21.1 16.2 14.3 20.6 12.3 11.9 17.6 27.4 18.4 18.9 128 <0.10 184 0.10 113 <0.10 144 <0.10 87 0.12 123 0.11 153 0.10 157 0.12 91 <0.10 158 0.13 144 <0.10 165 0.11 109 <0.10 104 0.15 125 <0.10 100 0.10 176 <0.10 204 0.12 175 <0.10 139 0.15 15 0.34 13 0.33 14 0.38 16 0.29 13 0.34 12 0.27 15 0.34 12 0.43 17 0.29 14 0.36 12 0.24 16 0.26 15 0.29 15 0.32 15 0.31 12 0.36 16 0.35 14 0.40 14 0.29 12 0.28 56 74 85 72 71 107 134 82 80 77 70 56 71 80 64 52 47 76 69 67 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group:: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 MODERATE TRACE MODERATE NONE TRACE NONE SMALL TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group:: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE TRACE MODERATE NONE NONE TRACE NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NT-HEMOL 80 NT-HEMOL 85 75 80 65 76 67 76 'NT-HEMOL 32 NT-HEMOL 16 33 35 29 26 24 31 74 99 78 NT-HEMOL 86 86 104 63 64 88 31 31 46 NT-HEMOL 23 35 46 27 26 32 788 . DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 15.7 14.3 20.9 18.2 22.9 16.9 17.5 17.5 16.9 21.0 NT-HEMOL 141 NT-HEMOL 134 157 141 202 153 162 159 NT-HEMOL <0.10 NT-HEMOL <0.10 <0.10 0.12 <0.10 0.12 0.12 <0.10 28.4 11.6 20.8 6.2 16.1 20.1 20.9 13.9 14.0 22.1 187 185 225 NT-HEMOL 191 157 240 166 165 152 0.10 <0.10 <0.10 NT-HEMOL <0.10 <0.10 <0.10 <0.10 <0.10 <0.10 14 0.33 15 0.29 16 0.27 19 0.30 13 0.27 17 0.36 14 0.26 14 0.31 14 0.33 15 0.24 14 0.45 17 0.36 14 0.42 16 0.28 13 0.30 12 0.36 13 0.29 13 0.25 14 0.39 13 0.31 62 39 61 72 22 65 45 54 61 76 91 64 39 67 52 28 48 55 55 36 Company Sanitized. Does not contain TSCA CBf St H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Pla TP g/dL ALB g/dL GLOB g/dL Male, Group: I - 0 mg/kg - Day 44 643143 65 104 6.4 3.9 2.5 643150 78 93 6.0 3.9 2.1 643185 41 111 6.5 4.1 2.4 643189 113 145 6.4 4.0 2.4 643204 177 106 6.6 4.3 2.3 643205 41 97 6.8 4.2 2.6 643235 89 109 6.5 4.0 2.5 643241 217 99 6.9 4.4 2.5 643288 79 105 6.7 4.0 2.7 643300 65 135 6.7 4.4 2.3 Male, Group: III - 25 mg/kg - Day 44 643173 126 96 6.5 4.3 2.2 643179 81 96 6.4 4.0 2.4 643180 124 120 6.4 3.9 2.5 643228 122 129 6.6 4.1 2.5 643240 56 89 6.1 4.0 2.1 643264 56 101 6.8 4.2 2.6 643272 46 96 6.7 4.3 2.4 643290 101 98 7.1 4.6 2.5 643292 97 107 6.8 4.5 2.3 643308 94 109 6.5 4.2 2.3 789 DuPont-5386 3ma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L SPEC 10.2 10.4 10.5 10.9 11.0 10.8 10.8 11.5 10.8 11.0 11.2 10.5 11.1 11.1 10.4 10.4 10.5 11.2 11.6 10.6 8.8 8.2 8.2 9.4 8.4 8.4 7.9 9.1 7.7 10.0 9.0 9.6 9.2 9.6 8.9 8.1 9.2 9.3 9.1 8.6 143.3 144.3 147.0 145.9 141.7 144.4 142.1 147.7 143.8 144.5 144.6 145.2 141.7 143.3 143.7 143.7 143.7 142.4 144.1 143.0 6.30 6.55 6.43 5.65 5.95 6.15 5.34 6.16 5.54 6.13 5.82 6.45 5.88 6.29 5.86 5.89 6.31 5.97 5.88 6.15 101.7 101.5 103.6 101.6 98.2 98.9 98.0 99.7 101.2 100.4 95.6 101.8 99.3 98.6 101.9 101.9 100.5 97.6 97.6 99.2 COmpany Sa""'2*- Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and TP g/dL ALB g/dL GLOB g/dL Male, Group : V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT-HEMOL 35 NT-HEMOL 122 28 65 52 86 85 130 104 NT-HEMOL 110 6.1 123 NT-HEMOL 112 6.6 88 6.5 109 7.2 126 6.8 103 6.8 103 6.7 106 7.0 Male, Group : VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 152 39 42 NT-HEMOL 57 16 35 55 47 37 147 7.8 103 7.6 95 7.5 107 NT-HEMOL 101 6.8 116 6.9 107 7.4 106 7.1 106 7.6 133 6.7 NT-HEMOL 4.1 NT-HEMOL 3.2 4.4 4.6 4.5 4.3 4.4 4.6 5.1 5.2 5.2 NT-HEMOL 4.7 4.8 5.1 4.9 5.2 4.5 NT-HEMOL 2.0 NT-HEMOL 3.4 2.1 2.6 2.3 2.5 2.3 2.4 2.7 2.4 2.3 NT-HEMOL 2.1 2.1 2.3 2.2 2.4 2.2 DuPont-5386 ma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L SPEC 10.7 9.9 11.2 11.1 10.4 11.5 11.1 10.7 10.9 10.9 NT-HEMOL 9.0 NT-HEMOL 10.4 8.8 9 ;5 10.9 9.5 9.0 9.0 142.4 145.0 144.3 144.9 144.5 145.0 144.2 145.6 144.2 143.6 11.6 11.1 11.4 11.1 10.7 11.2 11.0 11.1 11.4 11.4 10.3 9.2 9.5 NT-HEMOL 8.3 10.2 8.4 9.2 8.5 11.0 144.5 145.7 143.8 144.9 143.1 141.6 143.8 143.7 145.1 143.2 RNV 6.47 RNV 5.65 5.92 6.19 6.95 6.52 6.14 6.11 97.6 104.8 99.3 99.3 98.8 96.8 99.5 102.0 98.9 98.4 6.09 5.43 5.78 RNV 6.06 6.89 6.26 6.08 5.90 5.30 98.3 99.8 96.1 100.4 100.1 97.6 100.2 101.5 99.5 99.9 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 SMALL TRACE NONE NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 87 99 110 74 86 166 80 93 66 126 121 84 62 79 93 74 109 95 73 82 33 37 55 28 34 44 30 35 31 36 48 42 26 22 40 28 41 38 38 40 791 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 20.5 32.2 35.5 30.6 26.4 35.8 28.4 40.6 22.4 13.8 32.6 23.4 14.1 21.3 18.7 22.5 33.6 18.7 21.2 27.2 81 <0.10 131 <0.10 91 <0.10 103 <0.10 66 <0.10 84 <0.10 116 <0.10 116 0.12 71 <0.10 111 0.14 90 0.11 95 <0.10 76 <0.10 67 <0.10 93 <0.10 81 0.10 109 <0.10 138 <0.10 104 <0.10 98 <0.10 16 0.43 15 0.39 13 0.42 14 0.42 14 0.50 13 0.37 19 0.45 15 0.55 18 0.35 17 0.34 14 0.47 14 0.30 14 0.38 16 0.27 16 0.39 12 0.42 19 0.55 19 0.49 14 0.35 14 0.36 45 64 74 73 72 99 146 70 67 74 70 55 67 84 60 49 46 80 76 63 Company Sanitized. Does notcontain YSCA^31 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictsitywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR NONE TRACE SMALL SMALL NONE SMALL SMALL NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE NONE NONE SMALL . NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NT 64 71 80 104 103 76 79 63 77 97 85 174 98 81 85 110 81 71 73 NT 29 37 30 32 44 30 37 26 31 26 32 92 23 31 48 71 44 33 30 792 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL NT 16.5 28.8 18.8 13.9 26.7 26.6 29.8 21.9 27.2 16.3 24.1 28.1 13.7 25.0 39.2 41.9 28.3 19.7 21.6 NT NT 161 <0.10 174 <0.10 125 <0.10 112 <0.10 129 <0.10 136 <0.10 154 <0.10 135 <0.10 126 <0.10 201 <0.10 183 <0.10 174 <0.10 162 <0.10 230 <0.10 166 <0.10 243 <0.10 192 <0.10 176 <0.10 135 <0.10 NT NT 15 0.35 17 0.40 15 0.31 16 0.40 18 0.49 13 0.37 17 0.43 15 0.38 14 0.42 13 0.42 15 0.49 17 0.44 17 0.41 17 0.38 15 0.47 15 0.58 16 0.41 14 0.37 15 0.50 NT 37 71 37 23 67 39 49 54 55 82 44 33 54 58 34 34 46 38 42 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plas TP g/dL ALB g/dL GLOB g/dL Male, Group: I - 0 mg/kg - Day 91 643143 67 131 6.5 3.9 2.6 643150 99 80 6.1 4.0 2.1 643185 84 196 6.8 4.2 2.6 643189 200 110 6.8 4.4 2.4 643204 121 179 6.9 4.4 2.5 643205 52 90 6.7 4.0 2.7 643235 160 106 7.4 4.5 2.9 643241 145 151 7.6 4.7 2.9 643288 191 109 7.0 4.3 2.7 643300 153 102 6.8 4.3 2.5 Male, Group: III - 25 mg/kg - Day 91 643173 91 96 7.3 4.7 2.6 643179 97 87 6.2 4.2 2.0 643180 107 93 6.7 4.0 2.7 643228 161 105 6.6 4.3 2.3 643240 58 74 6.7 4.4 2.3 643264 127 104 6.8 4.4 2.4 643272 39 123 7.1 4.5 2.6 643290 76 117 7.2 4.6 2.6 643292 74 108 6.7 4.4 2.3 643308 149 109 6.7 4.4 2.3 793 DuPont-5386 ma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 10.5 10.1 11.7 10.7 11.8 10.5 11.2 12.0 10.9 10.2 10.7 9.9 10.6 10.5 10.2 10.8 11.2 10.8 10.7 10.8 8.6 8.1 12.0 7.4 12.9 7.8 7.5 11.7 6.9 8.6 145.2 147.7 150.8 146.1 149.3 147.2 147.1 149.3 146.5 143.0 7.4 7.9 8.6 7.9 8.0 7.8 12.4 10.0 8.5 8.2 146.2 147.0 144.1 144.7 145.2 147.3 148.5 145.1 144.9 145.8 6.36 6.89 7.35 5.54 6.52 6.10 6.01 6.88 5.43 6.25 100.7 101.9 103.6 100.1 103.2 98.9 99.4 100.3 98.9 100.0 6.25 6.08 6.54 5.85 5.66 5.38 6.64 6.07 6.49 5.69 97.5 102.6 99.4 99.3 101.9 99.2 102.2 100.3 100.5 97.6 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plas TP g/dL ALB g/dL GLOB g/dL Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NT NT NT NT 38 103 6.8 4.7 2.1 73 102 7.6 4.8 2.8 36 87 6.7 4.3 2.4 23 80 6.5 4.4 2.1 73 132 7.5 4.8 2.7 24 113 7.2 4.8 2.4 27 164 7.4 4.8 2.6 63 96 7.4 5.1 2.3 81 133 6.8 4.7 2.1 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 98 116 8.1 5.6 2.5 37 89 7.8 5.5 2.3 20 143 7.4 5.1 2.3 75 93 7.7 5.4 2.3 3.9 95 7.5 5.3 2.2 10 138 7.6 5.3 2.3 34 162 8.3 6.0 2.3 19 149 7.3 5.1 2.2 36 90 7.8 5.3 2.5 22 83 7.0 4.9 2.1 794 DuPont-5386 ima Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM NT 10.2 10.9 9.9 9.9 11.3 10.3 11.3 10.5 10.6 11.1 10.7 10.4 10.9 10.5 11.5 11.9 11.0 11.0 10.3 NT 7.7 8.6 8.8 8.3 9.7 9.6 10.8 8.1 8.9 NT 147.5 147.4 143.9 144.5 146.4 148.0 145.3 146.8 144.8 8.7 8.2 9.4 7.9 8.0 10.6 12.2 9.8 7.9 8.0 144.9 146.2 140.6 145.5 145.0 145.0 148.2 144.1 146.6 145.7 NT 5.79 6.13 6.25 6.24 6.09 6.85 6.89 6.04 5.86 NT 101.8 99.7 100.3 101.3 101.0 102.1 100.6 98.1 99.5 NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE 6.16 5.73 6.80 6.66 6.50 7.13 6.19 6.32 5.27 5.75 100.3 97.3 98.6 99.0 98.1 98.2 101.9 99.0 99.2 97.8 NONE NONE NONE NONE NONE TRACE NONE NONE NONE NONE Company Sanitized. Does not contain TSCA C B t H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU Ug/mL Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 DuPont-5386 795 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations______________________________ Animal Number FLIP PICT Individual Serum and Plasma Chemistry Values PFLU Vig/mL Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NSR 0.3 0.4 0.6 0.4 0.5 0.3 0.3 0.6 0.4 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE NONE NONE NONE NONE ' NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.7 0.6 0.7 0.6 0.9 0.5 0.6 0.6 0.7 0.7 DuPont-5386 796 Company Sanitized. Does not contain TSCA CBf 9H0--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plas SICT AST IU/L ALT IU/L Male, Group: I - 0 mg/kg - Day 125 643162 NONE NONE NONE 84 43 643172 NONE NONE NONE 68 28 643195 NONE NONE NONE 78 39 643226 TRACE NONE NONE 93 40 643237 NONE NONE NONE 71 22 643246 NONE NONE NONE 77 29 643253 TRACE NONE NONE 78 30 643262 TRACE NONE NONE 71 31 643303 NONE NONE NONE 81 38 643304 NONE NONE NONE 77 27 Male, Group: VII - 250 mg/kg - Day 125 643151 NONE NONE NONE 62 27 643165 NONE NONE NONE 91 74 643220 TRACE NONE NONE 77 33 643225 SMALL NONE NONE 93 34 643234 NONE NONE NONE 70 36 643236 NONE ' NONE NONE 76 31 643258 NONE NONE NONE 67 33 643266 NONE NONE NONE 84 29 643296 NONE NONE NONE 88 26 643316 NONE NONE NONE 78 41 797 DuPont-5386 ima Chemiatry Values SDH IU/L ALKP IU/L BILX mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 11.4 16.8 21.5 25.3 20.1 33.7 17.0 17.1 25.1 27.3 12.0 17.7 15.5 9.9 10.5 13.5 16.8 9.3 15.9 18.5 108 <0.10 71 <0.10 85 <0.10 48 0.11 73 <0.10 68 0.10 '96 <0.10 85 <0.10 101 <0.10 72 <0.10 92 <0.10 96 <0.10 75 <0.10 59 <0.10 60 <0.10 71 <0.10 95 <0.10 75 <0.10 62 <0.10 81 <0.10 15 0.30 15 0.37 13 0.40 16 0.46 15 0.51 17 0.36 17 0.43 14 0.39 16 0.40 13 0.34 19 0.42 19 0.35 19 0.41 20 0.41 14 0.36 18 0.41 19 0.42 17 0.32 18 0.52 16 0.34 56 76 70 55 76 91 75 88 73 89 58 63 50 71 44 72 58 52 44 50 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Male, Group: I - 0 mg/kg - Day 125 643162 41 92 6.9 4.2 2.7 10.4 7.4 146.2 643172 122 118 7.4 4.4 3.0 10.4 6.8 146.4 643195 124 103 6.6 4.4 2.2 10.2 6.7 146.5 643226 56 201 6.7 4.1 2.6 10.8 8.5 146.2 643237 64 113 6.5 4.2 2.3 10.7 7.9 146.6 643246 167 111 6.9 4.3 2.6 10.6 9.1 148.1 643253 91 102 7.3 4.4 2.9 10.7 7.8 146.3 643262 102 104 6.8 4.3 2.5 10.4 7.8 145.3 643303 . 98 180 7.5 4.6 2.9 11.2 11.6 146.9 643304 81 146 7.0 4.8 2.2 10.9 7.0 145.3 Male, Group: VII - 250 mg/kg - Day 125 643151 28 88 6.6 4.5 2.1 9.9 7.6 146.9 643165 66 99 6.5 4.4 2.1 9.9 7.7 147.3 643220 29 97 6.4 4.1 2.3 10.0 7.5 149.7 643225 58 102 7.0 4.5 2.5 10.1 7.6 145.5 643234 45 95 6.6 4.1 2.5 10.3 7.5 146.5 643236 57 106 7.2 4.3 2.9 10.4 7.4 146.4 643258 32 101 7.0 4.6 2.4 10.3 7.2 146.1 643266 43 119 6.4 3.9 2.5 9.9 8.3 143.7 643296 39 146 6.7 4.3 2.4 10.8 10.0 146.8 643316 154 107 7.0 4.7 2.3 10.2 7.4 146.9 K mmol/L 5.70 6.00 6.22 5.59 7.07 7.07 6.71 7.35 6.60 5.81 5.67 5.75 5.90 6.78 5.71 6.18 5.84 5.98 6.76 5.96 CL mmol/L 104.7 102.8 103.6 103.6 103.4 103.8 101.6 103.5 104.5 102.7 102.1 104.7 105.4 102.3 102.5 103.0 101.2 105.2 102.2 105.2 PHEM NONE TRACE NONE NONE NONE NONE NONE NT TRACE NONE NONE TRACE NONE NONE TRACE NT NONE NONE NONE NONE 798 Company Souzed. D s TM > n ^ TSCA061 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU pg/mL SPEC Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 NONE TRACE NONE NONE NONE NONE NONE NT NONE TRACE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 TRACE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE ' 0.2 0.2 0.1 0.1 QNS 0.2 0.1 0.1 0.1 0.1 Accidental spillage of serum DuPont-5386 799 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE TRACE NONE NONE NONE NONE NONE SMALL NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE 95 69 99 92 84 76 73 73 101 107 NT 60 73 73 106 73 59 93 65 82 36 28 44 45 37 39 33 33 46 33 NT 22 42 31 23 35 32 27 37 34 800 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 13.9 15.2 15.1 26.8 14.7 18.9 14.4 21.1 28.1 13.6 NT 12.8 13.5 19.3 20.9 27.4 20.5 19.6 17.3 13.7 98 0.10 45 0.14 80 0.14 67 0.15 64 0.12 .56 0.17 37 <0.10 60 0.13 67 0.13 81 0.17 NT NT 86 0.15 52 <0.10 61 0.11 108 <0.10 98 0.13 56 0.13 46 <0.10 54 0.15 74 0.15 16 0.40 14 0.36 16 0.37 18 0.43 15 0.36 17 0.48 15 0.40 15 0.41 20 0.42 17 0.40 NT NT 13 0.35 19 0.35 13 0.34 16 0.34 14 0.34 14 0.41 16 0.35 15 0.35 17 0.30 78 71 101 91 83 74 83 102 74 71 NT 91 84 73 82 98 102 64 128 82 Company Sanitized. Does not contain TSCA CBf ## H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number : SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643469 TRACE TRACE SMALL NONE NONE TRACE TRACE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE TRACE TRACE TRACE TRACE TRA'C NONE NONE TRACE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 91 ' 66 72 60 77 105 66 58 102 73 64 66 69 52 70 81 63 78 75 72 29 31 28 30 37 28 24 29 40 37 29 26 48 22 35 29 27 27 23 22 801 0 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 14.0 10.5 13.7 15.1 16.3 21.9 13.9 15.5 20.4 21.6 14.0 13.0 19.9 9.4 19.1 16.4 14.7 15.1 25.1 11.2 81 0.13 93 0.15 67 0.13 58 0.10 95 <0.10 114 0.12 61 0.10 80 0.17 102 <0.10 78 <0.10 87 <0.10 73 0.10 73 <0.10 87 0.12 75 <0.10 71 0.12 102 <0.10 61 0.14 118 0.13 61 <0.10 16 0.39 15 0.31 12 0.28 16 0.41 19 0.33 19 0.42 13 0.34 17 0.34 14 0.32 16 0.33 15 0.43 15 0.26 15 0.31 16 0.36 19 0.36 16 0.35 17 0.37 13 0.31 14 0.51 17 0.39 82 94 74 81 63 70 107 85 77 89 72 68 108 87 89 88 102 100 91 117 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations # DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group : II - 0 mg/kg - Day 45 643354 41 104 7.1 4.5 2.6 10.5 6.8 142.8 643361 82 98 7.1 4.9 2.2 11.1 7.7 143.0 643362 42 101 6.9 4.5 2.4 10.7 6.8 141.3 643374 43 92 7.1 5.0 2.1 11.4 7.4 145.5 643398 78 97 6.6 4.7 1.9 10.7 8.0 142.2 643406 63 84 7.4 5.1 2.3 11.0 7.4 142.1 643436 95 94 7.8 5.5 2.3 11.0 7.4 142.1 643463 107 117 8.3 5.9 2.4 11.8 8.8 146.1 643477 41 98 7.7 5.5 2.2 li.i 8.0 148.5 643486 35 87 6.6 4.5 2.1 10.6 6.6 141.4 Female, Group : IV - 25 mg/kg - Day 45 643321 NT NT NT NT NT NT NT NT 643324 43 119 7.6 5.3 2.3 11.2 6.7 145.7 643364 34 95 6.9 4.7 2.2 11.1 7.5 144.0 643380 110 107 7.6 5.1 2.5 11.0 5.8 142.8 643389 124 133 6.7 4.2 2.5 11.3 10.0 148.1 643390 50 98 8.1 5.2 2.9 11.8 8.1 146.0 643396 128 109 7.7 5.4 2.3 12.0 8.6 142.1 643410 70 113 7.4 5.2 2.2 11.0 7.3 140.0 643433 114 115 7.4 5.3 2.1 11.2 7.4 141.8 643458 25 90 7.0 4.7 2.3 10.5 7.1 140.8 K mmol/L 5.59 5.71 5.60 6.11 5.56 5.75 5.55 5.53 5.87 5.37 NT 5.29 5.99 5.27 6.52 5.82 5.90 5.58 5.42 5.81 CL mmol/L 101.5 100.2 100.8 100.6 101.6 100.6 100.4 99.0 102.2 100.6 NT 100.8 101.7 100.1 102.6 99.4 97.2 98.6 99.8 99.1 SPEC 802 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group.: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 23 96 8.2 5.8 2.4 11.4 8.0 143.5 28 99 7.5 5.3 2.2 11.1 7.5 141.6 54 109 7.4 5.3 2.1 11.0 7.5 142.4 84 99 8.2 5.5 2.7 11.9 7.4 142.9 36 96 7.8 5.4 2.4 11.4 8.3 142.8 34 89 7.1 4.9 2.2 10.6 8.6 143.6 53 98 7.7 5.5 2.2 11.3 7.6 139.8 47 94 7.6 5.2 2.4 11.4 7.9 141.9 31 98 7.7 5.4 2.3 11.2 9.0 141.0 53 98 7.6 5.4 2.2 11.1 7.2 145.6 Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 26 101 8.4 5.9 2.5 11.8 7.9 142.6 45 113 8.1 5.7 2.4 12.0 7.2 142.7 52 95 8.1 5.6 2.5 11.8 8.6 143.4 43 100 8.2 5.9 2.3 12.0 8.7 142.4 58 96 8.9 6.0 2.9 12.2 8.0 144.1 34 112 8.3 5.9 2.4 11.7 7.9 142.8 35 98 7.9 5.4 2.5 11.4 7.7 142.8 65 100 7.5 5.5 2.0 11.2 7.5 142.9 33 101 8.6 6.0 2.6 12.1 7.6 146.7 30 94 7.5 5.3 2.2 11.1 7.1 142.6 K mmol/L 5.91 5.40 6.12 5.91 6.26 5.77 5.95 6.17 5.83 5.45 5.94 5.88 6.33 6.05 6.57 6.41 6.32 6.32 6.98 6.42 CL mmol/L 101.5 100.8 99.6 97.9 98.2 100.7 99.8 98.3 100.3 100.0 99.6 100.2 97.8 98.5 98.4 100.7 99.7 99.7 100.0 100.4 SPEC 803 Company Sanitized. Does not contain TSCA CBl # H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE SMALL NONE NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE 106 76 92 160 88 72 67 76 77 89 NT 67 116 71 86 71 60 78 75 85 37 39 29 52 28 25 26 28 35 28 NT 26 40 28 46 32 34 29 27 32 804 # DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 11.0 20.5 9.3 36.9 19.8 18.4 19.0 19.0 20.5 14.8 NT 18.0 8.3 17.3 16.5 20.7 17.8 20.3 13.4 15.1 60 <0.10 38 0.11 49 0.11 32 0.22 52 0.12 38 0.16 29 <0.10 34 0.15 47 0.20 36 0.17 NT NT 52 0.10 28 <0.10 36 0.13 65 <0.10 47 <0.10 25 0.13 27 0.12 44 0.17 72 0.13 20 0.41 18 0.48 16 0.41 16 0.46 15 0.54 18 0.56 15 0.46 13 0.52 17 0.42 17 0.48 NT NT 13 0.45 18 0.41 14 0.39 20 0.40 15 0.48 16 0.44 17 0.42 17 0.46 15 0.52 65 78 92 108 66 73 70 91 74 77 NT 88 83 73 94 92 125 60 109 86 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number SHEM SLIP Individual Serum and Plasma SICT AST IU/L ALT IU/L Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NONE TRACE SMALL NONE NONE NONE SMALL NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE 99 93 70 91 83 90 100 88 100 76 126 NT 97 59 98 82 73 84 88 77 28 34 28 41 30 31 36 34 35 36 57 NT 71 28 29 39 40 26 28 28 805 DuPont-5386 Chemistry Values SDH IU/L ALKP IU/L BILI mg/dL BUN mg/dL CREA mg/dL CHOL mg/dL 10.2 20.9 13.3 17.5 23.3 16.0 23.3 18.4 21.3 18.5 21.7 NT 25.1 12.6 9.7 22.5 17.5 15.6 15.4 14.6 63 0.14 62 <0.10 40 0.20 34 <0.10 72 <0.10 58 0.10 40 <0.10 44 0.10 75 0.11 64 0.10 76 <0.10 NT NT 50 <0.10 58 0.13 39 0.14 37 0.14 53 <0.10 42 0.15 84 0.13 29 0.12 17 0.60 13 0.51 12 0.50 15 0.44 17 0.53 21 0.38 13 0.57 17 0.48 17 0.64 14 0.44 16 0.47 NT NT 15 0.49 14 0.42 15 0.59 15 0.59 16 0.47 16 0.50 19 0.51 17 0.44 71 73 64 85 57 73 93 71 73 101 68 NT 101 96 110 92 105 104 59 120 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number TRIG mg/dL GLUC . mg/dL Individual Serum and Plas TP g/dL ALB g/dL GLOB g/dL Female, Group: II - 0 mg/kg - Day 93 643354 61 84 7.1 643361 453 101 7.9 643362 92 92 6.7 643374 122 87 8.4 643398 63 99 6.9 643406 75 76 7.5 643436 363 96 7.8 643463 158 100 8.1 643477 113 89 7.5 643486 95 91 7.4 Female, Group : IV - 25i mg/kg - Day 93 643321 NT NT NT 643324 74 101 7.8 643364 52 92 7.6 643380 166 99 7.9 643389 32 91 7.6 643390 76 96 8.2 643396 151 96 8.7 643410 64 105 7.8 643433 110 101 7.5 643458 42 95 7.4 4.5 2.6 5.4 2.5 4.5 2.2 6.1 2.3 4.7 2.2 5.1 2.4 5.4 2.4 5.8 2.3 5.6 1.9 5.0 2.4 NT 5.4 5.2 5.5 4.9 5.6 6.3 5.6 5.2 5.0 NT 2.4 2.4 2.4 2.7 2.6 2.4 2.2 2.3 2.4 806 # DuPont-5386 ma Chemistry Values CALC mg/dL IPHS mg/dL NA mmol/L K mmol/L CL mmol/L PHEM 10.5 11.0 10.6 11.4 10.4 10.7 10.9 11.0 10.9 10.5 NT 10.7 10.9 11.0 10.5 11.4 12.0 11.0 10.7 10.5 6.4 142.8 5.6 140.9 6.1 143.2 4.9 143.1 6.1 146.1 5.6 142.8 6.3 143.4 4.5 144.4 5.3 146.0 4.9 144.0 NT NT 5.8 143.6 5.8 142.4 6.0 141.2 6.7 141.2 5.7 146.0 6.4 143.0 5.0 143.8 6.5 141.3 5.9 143.1 5.76 4.68 5.33 5.06 5.29 5.59 5.32 4.93 5.84 5.14 102.8 98.4 100.6 95.9 101.9 97.6 99.0 97.8 97.6 100.3 NONE SMALL NONE NONE NONE NONE TRACE NONE NONE TRACE NT 5.21 5.75 5.18 5.48 5.63 5.15 5.01 5.22 5.02 NT 97.1 103.8 97.7 98.8 98.7 95.3 100.1 99.2 99.1 NSR NONE NONE NONE NONE NONE NONE NONE NONE NONE Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations # DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: VI - 100 mg/kg - Day 93 643322 41 84 8.3 643323 29 129 8.4 643366 74 108 8.1 643367 100 87 8.3 643392 32 98 8.7 643409 37 93 7.5 643461 40 128 8.5 643462 49 84 8.0 643472 44 84 9.1 643489 81 101 8.3 Female, Group : VIII - 250 mg/kg Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 56 97 8 . 8 NT NT NT 61 98 8.7 69 92 8.5 88. 99 9.1 27 97 8.9 57 90 7.9 . 26 85 8.6 28 93 8.3 72 91 8.7 6.0' 6.0 6.0 5.8 6.1 5.4 5.9 5.9 6.5 5.9 6.2 NT 6.0 6.0 6.1 6.2 5.4 6.3 6.0 6.2 2.3 2.4 2.1 2.5 2.6 2.1 2.6 2.1 2.6 2.4 2.6 NT 2.7 2.5 3.0 2.7 2.5 2.3 2.3 2.5 11.3 12.0 11.4 11.2 11.4 10.6 11.6 11.2 11.4 11.1 11.6 NT 11.4 12.0 11.9 11.7 10.9 11.6 11.3 11.4 6.4 141.4 9.5 147.0 5.4 143.7 5.2 142.0 6.8 145.5 5.8 142.2 8.4 147.6 6.8 142.8 6.7 145.3 6.1 143.3 6.8 144.1 NT NT 6.2 142.0 7.2 144.4 7.7 141.6 6.5 145.0 6.4 144.1 7.3 143.2 5.6 141.9 5.6 142.3 K mmol/L 5.35 5.54 5.74 5.16 6.17 5.06 6.22 5.92 5.61 5.41 5.86 NT 5.86 6.22 5.95 5.87 5.91 6.95 5.53 6.27 CL mmol/L 99.1 103.6 99.3 96.4 99.4 97.7 101.5 100.0 98.5 97.7 98.8 NT 95.0 97.8 97.4 99.4 99.2 98.3 96.7 98.5 PHEM NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NSR NONE NONE NONE NONE NONE NONE NONE NONE 807 C0mpanySanMied. Does noiconiali, TSCACBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU jig/mL Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.3 0.1 0.2 0.1 0.1 Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT NONE NONE NONE NONE NONE" NONE NONE NONE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE NONE NSR 0.2 0.2 0.2 0.4 0.2 0.2 0.2 0.2 0.2 DuPont-5386 808 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU ug/mL Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.5 0.3 0.4 0.5 0.4 0.2 0.4 0.4 0.4 0.2 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NT NONE NONE NONE NONE ' NONE NONE NONE NONE NONE NT NONE NONE NONE TRACE NONE NONE NONE NONE 1.1 NSR 1.0 0.6 1.0 0.6 0.7 1.0 0.6 0.6 DuPont-5386 809 Company Sanitized. Does not contain TSCA C B f H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations # DuPont-5386 Animal Number SHEM SLIP Individual Serum and Plasma Chemistry Values SICT AST IU/L ALT IU/L SDH IU/L ALKP IU/L Female, Group : II - 0 mg/kg - Day 125 643330 NONE NONE NONE 90 42 16.9 643336 NSR NT NT NT NT NT 643377 NONE NONE NONE 132 83 25.8 643387 NONE NONE NONE 74 26 14.0 643405 NONE NONE NONE 223 129 49.6 643415 NONE NONE NONE 224 126 39.0 643425 TRACE NONE NONE 138 72 31.6 643426 NONE NONE NONE 80 31 18.7 643448 NONE NONE NONE 87 46 19.4 643453 NONE NONE NONE 70 34 17.6 Female, Group: VIII - 250 mg/kg - Day 125 643345 NONE NONE NONE 75 31 15.1 643347 NONE NONE NONE 72 40 16.9 643351 NONE NONE NONE 84 25 17.2 643358 NONE NONE NONE 95 48 17.4 643423 NONE. NONE NONE 131 42 16.9 643441 NONE TRACE NONE 81 34 18.1 643444 NONE NONE NONE 712 264 103.2 643456 NONE NONE NONE 70 29 14.4 643474 NONE NONE NONE 119 48 12.0 643481 NONE NONE NONE 82 60 18.4 24 NT 21 31 46 .18 58 35 33 34 28 43 41 32 72 39 36 24 40 24 BILI mg/dL 0.16 NT 0.14 <0.10 0.12 <0.10 <0.10 0.14 0.12 0.11 <0.10 0.11 <0.10 0.10 0.12 0.11 0.24 <0.10 <0.10 <0.10 BUN mg/dL 17 NT 12 18 17 13 17 13 21 16 15 17 16 18 17 15 16 12 19 18 CREA mg/dL 0.58 NT 0.48 0.45 0.56 0.44 0.44 0.49 0.43 0.43 0.45 0.50 0.56 0.49 0.51 0.44 0.48 0.41 0.46 0.52 CHOL mg/dL 115 NT 127 75 83 172 83 136 55 108 58 65 64 140 85 87 224 107 62 92 810 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number TRIG mg/dL GLUC mg/dL Individual Serum and Plasma Chemistry Values TP g/dL ALB g/dL GLOB g/dL CALC mg/dL IPHS mg/dL NA mmol/L Female, Group: II - 0 mg/kg - Day 125 643330 85 116 8.9 6.0 2.9 11.3 6.3 145.1 643336 NT NT NT NT NT NT NT NT 643377 127 92 8.8 6.1 2.7 11.4 4.8 145.8 643387 81 103 8.1 5.5 2.6 10.9 5.2 144.8 643405 219 155 8.1 5.6 2.5 11.9 7.8 147.5 643415 271 92 8.8 5.8 3.0 11.3 5..0 146.0 643425 58 108 7.5 5.3 2.2 10.3 4.9 146.5 643426 162 99 8.1 5.7 2.4 11.0 5.6 145.7 643448 71 97 7.5 5.5 2.0 10.5 5.9 145.2 643453 14 8 99 8.1 5.5 2.6 11.0 5.9 142.7 Female, Group: VIII - 250 mg/kg - Day 125 643345 36 99 7.7 5.3 2.4 10.6 6.0 145.3 643347 46 94 8.5 5.6 2.9 10.8 5.3 146.6 643351 71 117 7.4 5.2 2.2 10.9 7.4 144.1 643358 248 100 8.8 6.1 2.7 11.3 7.5 142.4 643423 37. 110 8.2 5.2 3.0 10.9 8.1 143.4 643441 306 135 7.8 5.4 2.4 10.7 5.7 145.0 643444 74 97 8.7 5.6 3.1 11.3 5.8 142.6 643456 56 85 B.l 5.3 2.8 10.5 6.2 142.6 643474 34 99 8.2 5.6 2.6 10.6 6.1 140.8 643481 114 106 8.5 5.8 2.7 11.4 5.6 145.8 K mmol/L 5.17 NT 4.90 5.86 5.86 4.98 5.59 4.78 4.91 5.70 5.36 5.51 6.10 5.38 4.76 4.85 5.92 5.28 5.18 6.11 CL mmol/L 103.1 NT 100.9 104.3 103.3 101.7 104.7 101.2 103.0 101.1 102.7 102.2 105.0 100.5 105.3 105.5 102.0 101.2 104.1 103.8 PHEM NONE NT NONE TRACE NONE NONE NONE TRACE TRACE NONE NONE NONE NONE TRACE NONE NONE NONE NONE TRACE NONE 811 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number PLIP PICT Individual Serum and Plasma Chemistry Values PFLU Hg/mL Female, Group : II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 43426 643448 643453 NONE NT NONE NONE NONE TRACE NONE NONE NONE TRACE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE 0.1 NT 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 NONE NONE NONE TRACE NONE NONE .NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE NONE 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 # DuPont-5386 \ 812 Company Sanitized. Does nt contain TSCACBf H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Male, Group: I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 LIGHT LIGHT LIGHT LIGHT LIGHT MEDIUM LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR HAZY HAZY CLOUDY CLOUDY CLOUDY HAZY HAZY HAZY Male, Group : III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 LIGHT LIGHT LIGHT LIGHT LIGHT. LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLOUDY HAZY HAZY CLEAR HAZY CLEAR CLOUDY CLOUDY CLOUDY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG PH UGLU mg/dL KET mg/dL UBIL BLD 10.4 3.9 6.9 8.6 10.8 3.6 12.4 21.4 4.4 3.2 16.8 4.6 19.0 7.0 4.6 14.2 5.8 11.0 5.6 11.0 782 1373 1179 1363 1083 1631 967 526 1519 1404 1.024 1.043 1.036 1.042 1.031 1.052 1.029 1.017 1.047 1.044 547 1724 684 1003 1625 618 1689 844 659 799 1.018 1.053 1.021 1.033 1.049 1.020 1.051 1.027 1.021 1.026 7.0 NEGATIVE 15 NEGATIVE SMALL 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE TRACE 6.5 NEGATIVE 5 SMALL SMALL 8.0 NEGATIVE NEGATIVE NEGATIVE SMALL 8.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 6.5 NEGATIVE 8.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 7.5 NEGATIVE 8.5 NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 15 SMALL MODERATE 5 NEGATIVE NEGATIVE 5 NEGATIVE LARGE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE MODERATE 15 NEGATIVE MODERATE 5 NEGATIVE MODERATE 813 C0MMny S" * 1-0 - "Oicoman TSCACBl  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Qeneration Reproductive Evaluations # DuPont-5386 Animal Number QUAL COL CLAR Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 LIGHT LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY HAZY CLEAR CLOUDY HAZY CLOUDY HAZY Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643296 643315 LIGHT MEDIUM LIGHT LIGHT LIGHT. LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY HAZY HAZY CLEAR HAZY CLEAR HAZY HAZY CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 17.8 3.3 3.3 4.0 3.9 4.8 13.4 6.0 16.2 7.4 5.5 3.2 9.6 5.6 23.5 7.8 25.0 11.8 59.0 20.4 611 1924 QNS 2334 1663 1394 820 1352 591 1305 1219 2502 848 1609 419 838 505 743 217 475 1.020 1.058 1.075 1.068 1.051 1.044 1.025 1.043 1.019 1.042 1.039 1.068 1.026 1.050 1.014 1.027 1.016 1.024 1.007 1.016 7.0 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 6.5 NEGATIVE 7.0 NEGATIVE 6.5 NEGATIVE 8.5 NEGATIVE 7.0 NEGATIVE 7.5 NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 15 NEGATIVE NEGATIVE 5 NEGATIVE TRACE 5 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 8.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 8.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE SMALL 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE MODERATE 814 Company Sanitized. D oe, ,,otcontom T S C A C B , H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Male, Group: I - 0 mg/kg - Day 44 643143 0.2 45 643150 0.2 84 643185 0.2 75 643189 0.2 149 643204 0.2 51 643205 0.2 119 643235 0.2 78 643241 0.2 20 643288 0.2 57 643300 0.2 93 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 0.2 1.0 0.2 0.2 0.2 . 0.2 0.2 0.2 0.2 0.2 19 175 24 50 61 21 104 50 58 63 FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED DuPont-5386 815 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL Le, Group: V - 100 mg/kg - Day 44 643175 0.2 24 643224 0.2 163 643243 0.2 144 643247 0.2 152 643250 0.2 142 643257 0.2 151 643275 0.2 47 643311 0.2 81 643314 0.2 59 643318 0.2 63 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 81 198 51 133 16 45 22 73 10 26 Individual Urinalysis Values DuPont-5386 816 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 MEDIUM MEDIUM MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR CLEAR HAZY HAZY CLEAR HAZY CLOUDY CLEAR CLEAR Male, Group: III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 MEDIUM MEDIUM LIGHT MEDIUM MEDIUM LIGrfT MEDIUM MEDIUM MEDIUM MEDIUM YELLOW YELLOW YELLOW BROWN YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY CLEAR CLOUDY CLEAR HAZY CLOUDY HAZY HAZY CLOUDY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG PH UGLU mg/dL KET mg/dL UBIL BLD 3.5 ' 1.4 9.0 10.0 6.4 5.4 12.0 19.0 1.8 2.2 2200 UTD 1440 1289 1077 1367 1322 614 UTD UTD 1.064 1.076 1.044 1.040 1.035 1.045 1.044 1.022 >1.083 1.065 RNV 12.0 8.3 4.2 5.7 26.0 13.0 6.6 10.0 4.5 1134 744 851 1924 1366 560 784 1154 1119 1947 1.035 1.028 1.026 1.059 1.041 1.020 1.024 1.036 1.033 1.058 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE SMALL NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 SMALL NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE LARGE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 MODERATE LARGE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE SMALL 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 817 Company Sanitized. Does not contain TSCA C 8 00 9H0--2D4a5y16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations__________________ 0 DuPont-5386 Animal Number QUAL COL CLAR Male, Group: V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NT MEDIUM MEDIUM LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT MEDIUM NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT HAZY HAZY HAZY CLOUDY CLEAR CLOUDY CLEAR HAZY HAZY Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM' LIGHT LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY CLEAR CLOUDY CLEAR CLEAR CLEAR CLOUDY HAZY CLOUDY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD NSR 4.2 5.4 23.0 3.3 6.7 7.7 7.5 28.0 4.0 18.0 8.6 12.0 8.0 14.0 12.0 27.0 18.0 27.0 9.2 NT 1666 1948 642 2020 1414 1167 1088 376 1510 NT 1.049 1.058 1.021 1.061 1.043 1.036 1.035 1.014 1.047 535 1181 892 1221 717 909 540 452 443 1037 1.020 1.037 1.031 1.039 1.024 1.029 1.019 1.015 1.017 1.034 NT NT NT NT NT 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE SMALL 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE 15 SMALL NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE TRACE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 818 Company Sanitized. Does not contain TSCA CB #; * H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations______________________ Animal Number URO EU/dL UFLU pg UMTP mg/dL Male, Group: I - 0 mg/kg - Day 91 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 0.2 15.9 0.2 QNS 0.2 28.7 0.2 22.6 0.2 15.1 0.2 16.0 0.2 25.1 0.2 18.0 0.2 QNS 0.2 QNS Male, Group : III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 0.2 0.2 0.2 1.0 0.2 . 0.2 0.2 0.2 0.2 0.2 QNS 185.6 263.3 197.0 173.8 251.4 197.9 192.0 267.7 188.2 147 149 74 102 76 86 74 25 177 276 51 34 40 184 49 15 23 113 81 187 Individual Urinalysis Values SPEC Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: PARTIAL VOLUME / ACCIDIDENTAL SPILLAGE # DuPont-5386 819 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU ug UMTP mg/dL Male, Group: V - 100 mg/kg - Day 91 643175 43224 643243 643247 643250 643257 643275 643311 643314 643318 NT NSR 0.2 379.3 0.2 761.9 0.2 988.9 0.2 710.4 0.2 839.7 0.2 540.2 0.2 587.6 0.2 676.5 0.2 480.0 NT 95 151 23 168 115 64 63 32 104 Male, Group: VII - 250 mg/kg - Day 91 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 0.2 0.2 0.2 0.2 0.2 0: 2 ' 0.2 0.2 0.2 0.2 1911.3 1537.7 1378.9 1093.7 1259.4 1595.8 1947.2 992.5 1592.1 1427.1 24 56 63 71 27 30 17 21 35 56 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED DuPont-5386 820 Company Sanitized. Does not contain TSCA C Bl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Male, Group : I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 LIGHT LIGHT LIGHT LIGHT MEDIUM MEDIUM MEDIUM LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR CLEAR CLEAR HAZY HAZY HAZY CLEAR HAZY CLEAR Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 LIGHT MEDIUM MEDIUM MEDIUM MEDIUM LIGHT' MEDIUM LIGHT LIGHT MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY HAZY HAZY HAZY HAZY HAZY CLEAR HAZY Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 13.4 8.7 17.8 14.2 10.4 5.9 7.9 11.8 6.7 23.2 6.5 3.5 4.2 2.0 4.1 13.4 3.2 21.0 11.2 3.1 803 984 501 744 853 1450 1391 1033 1357 404 1048 1971 1714 3194 2244 723 2743 642 744 2569 1.026 1.031 1.017 1.025 1.027 1.046 1.043 1.034 1.043 1.014 1.034 1.059 1.051 1.082 1.064 1.025 1.074 1.021 1.025 1.073 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE 5 NEGATIVE NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 7.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 SMALL NEGATIVE 7.0 NEGATIVE 15 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 15 SMALL NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE 6.5 NEGATIVE 15 SMALL NEGATIVE 821 Company Sanitized. Does not contain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU ug UMTP mg/dL Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 0.2 11.9 0.2 10.3 0.2 16.0 0.2 16.9 0.2 12.6 0.2 10.0 0.2 15.7 0.2 18.3 0.2 15.0 0.2 15.7 74 45 41 29 30 116 88 52 176 13 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 0.2 0.2 0.2 0.2 0.2. O'.2 0.2 0.2 0.2 0.2 76.9 55.0 96.0 78.1 103.7 109.1 85.7 131.3 71.2 66.6 41 134 86 234 121 57 197 73 44 220 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED DuPont-5386 822 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations_______________________________________________________ DuPont-5386 Animal Number UFLU U9 Male , Group : I - 0 mg/kg - Day 181 643145 643210 643232 643265 643268 9.7 9.8 20.7 9.5 10.7 Male , Group : III - 25 mg/kg - Day 181 643202 643293 643305 643306 643310 21.4 25.0 26.7 18.6 22.4 Male , Group : V - 100 mg/kg - Day 181 643159 643169 643181 643206 643286 52.2 34.7. 41.0 21.9 45.6 Male , Group : VII - 250 mg/kg - Day 181 643149 643152 643178 643283 643295 64.4 64.2 71.0 79.9 66.0 Individual Urinalysis Values 823 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Female, Group:: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 LIGHT LIGHT MEDIUM LIGHT NT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW CLOUDY CLEAR HAZY CLOUDY NT HAZY CLOUDY CLOUDY HAZY CLEAR Female, Group:: IV - 2Si mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT LIGHT LIGHT LIGHT LIGHT. LIGHT LIGHT LIGHT LIGHT LIGHT NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT HAZY CLEAR HAZY CLEAR HAZY HAZY CLEAR HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG PH UGLU mg/dL KET mg/dL UBIL BLD 9.0 11.2 1.3 5.4 QNS 12.0 6.2 2.8 1.0 2.9 NSR 10.0 3.2 12.0 3.6 5.0 9.8 7.5 1.6 9.2 583 705 3203 779 NT 578 681 2172 QNS 1468 1.018 1.022 1.068 1.023 NT 1.017 1.022 1.062 >1.083 1.044 NT 782 847 802 1461 1085 650 915 2888 620 NT 1.024 1.026 1.024 1.044 1.034 1.020 1.028 1.074 1.019 8.5 NEGATIVE NEGATIVE NEGATIVE MODERATE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE TRACE NT NT NT NT NT 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE TRACE 7.0 NEGATIVE NEGATIVE SMALL TRACE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE SMALL 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 SMALL NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 824 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAL COL CLAR Female, Group : VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY CLEAR CLEAR CLEAR HAZY CLEAR HAZY Female, Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT LIGHT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY HAZY HAZY HAZY HAZY CLEAR CLEAR CLOUDY HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 12.0 12.4 11.2 8.8 4.0 2.1 5.6 7.8 6.2 11.4 16.0 17.0 20.4 11.2 6.4 15.6 12.2 8.2 7.0 12.2 482 470 633 843 1036 1265 907 840 775 608 1.015 1.015 1.019 1.025 1.031 1.038 1.027 1.025 1.024 1.019 414 471 377 680 1011 427 507 683 760 555 1.013 1.015 1.012 1.021 1.030 1.014 1.016 1.021 1.023 1.017 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 8.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 825 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Female, Group: II - 0 mg/kg - Day 45 643354 0.2 24 FECAL CONTAMINATION OBSERVED 643361 0.2 12 643362 0.2 72 Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME 643374 0.2 12 643398 NT QNS 643406 0.2 12 643436 0.2 29 FECAL CONTAMINATION OBSERVED 643463 0.2 88 FECAL CONTAMINATION OBSERVED 643477 0.2 94 Sample status : URINALYSIS TO BE RUN MANUALLY - LOW VOLUME 643486 0.2 25 Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT 0.2 0.2 0.2 0.2 . 0:2' 0.2 0.2 0.2 0.2 NT 14 16 15 30 21 13 16 80 9 FECAL CONTAMINATION OBSERVED # DuPont-5386 826 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number URO EU/dL UMTP mg/dL SPEC Individual Urinalysis Values Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 13 12 FECAL CONTAMINATION OBSERVED 12 18 20 26 24 22 17 11 lale. Group: VIII - 250 mg/kg Day 45 643332 0.2 14 643340 0.2 11 643341 0.2 9 643359 0.2 41 643370 0.2. 37 643404 0:2 11 643408 0.2 28 643435 0.2 20 f e c a l Co n t a m i n a t i o n o b s e r v e d 643446 0.2 26 643466 0.2 17 DuPont-5386 827 Company Sanitized. Does not contain TSCA CbI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number QUAD COL CLAR Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 LIGHT DARK MEDIUM DARK NT NT MEDIUM DARK DARK NT YELLOW YELLOW YELLOW YELLOW NT NT YELLOW YELLOW YELLOW NT CLOUDY CLOUDY CLEAR HAZY NT NT HAZY HAZY HAZY NT Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT LIGHT MEDIUM MEDIUM MEDIUM MEDIUM MEDIUM NT MEDIUM DARK NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW NT YELLOW YELLOW NT HAZY HAZY HAZY CLEAR CLEAR CLEAR NT HAZY CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 9.4 771 1.023 4.8 1080 1.034 3.0 1684 1.049 0.6 NT QNS QNS NT NT QNS NT NT 1.5 UTD 1.071 0.9 UTD >1.083 1.5 QNS >1.083 QNS NT NT NSR NT NT 6.6 1030 1.029 5.4 1096 1.034 8.6 760 1.023 2.2 1722 1.051 3.0 1610 1.049 4.0 1368 1.043 QNS NT NT 7.5 843 1.026 1.6 UTD 1.081 7.5 NEGATIVE NEGATIVE NEGATIVE MODERATE 8.0 NEGATIVE NEGATIVE SMALL MODERATE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE SMALL TRACE NT NT NT NT NT NT NT NT NT NT 6.0 NEGATIVE NEGATIVE SMALL NEGATIVE 6.5 NEGATIVE TRACE SMALL NEGATIVE 5.5 NEGATIVE 5 SMALL TRACE NT NT NT NT NT NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE MODERATE 7.5 NEGATIVE NEGATIVE NEGATIVE SMALL 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE SMALL 6.5 NEGATIVE 5 SMALL NEGATIVE 828 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations_______________________________________ DuPont-5386 Animal Number QUAL COL CLAR Female, Group : VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 DARK MEDIUM LIGHT MEDIUM MEDIUM DARK DARK DARK MEDIUM MEDIUM YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR CLEAR HAZY CLEAR CLEAR CLOUDY HAZY CLEAR CLEAR CLEAR Female, Group:: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 LIGHT NT LIGHT MEDIUM LIGHT LIGHT MEDIUM LIGHT MEDIUM MEDIUM YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW HAZY NT CLEAR HAZY CLEAR HAZY CLEAR CLEAR CLEAR CLEAR Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 1.8 8.3 9.4 1.5 2.0 2.5 2.6 3.4 1.7 7.0 12.4 NSR 7.9 24.0 23.4 3.5 6.3 5.3 6.5 7.0 UTD 759 579 2411 1513 2065 1715 1750 2013 1067 1.068 1.025 1.019 1.066 1.047 1.059 1.054 1.053 1.057 1.031 539 NT 815 429 403 812 1033 816 1216 812 1.019 NT 1.024 1.015 1.013 1.026 1.030 1.026 1.039 1.024 6.0 NEGATIVE NEGATIVE SMALL NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE TRACE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE SMALL SMALL 5.5 NEGATIVE 5 NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 7.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 829 Company Sanitized, Does not contain TSCA CBl 0 H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU ug UMTP mg/dL Female, Group: II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 0.2 14.0 0.2 19.4 0.2 QNS 0.2 QNS NT QNS NT QNS 0.2 QNS 0.2 QNS 0.2 QNS QNS 19 61 30 QNS QNS QNS 152 140 99 QNS Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NT 0.2 0.2 0.2 0.2 0,2 ' 0.2 NT 0.2 0.2 NSR 100.5 107.9 52.2 QNS 84.2 99.7 QNS 150.5 QNS NT 14 26 25 38 41 145 QNS 25 75 Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME Sample status: URINALYSIS TO BE RUN MANUALLY - LOW VOLUME FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED FECAL CONTAMINATION OBSERVED # DuPont-5386 830 --r Company Sanitized. Does notcontain tsgacbi ## H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU pg UMTP mg/dL Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 0.2 QNS 0.2 513.2 0.2 349.2 0.2 QNS 0.2 QNS 0.2 QNS 0.2 QNS 0.2 363.9 0.2 QNS 0.2 615.0 92 16 13 80 48 90 79 75 52 20 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 0.2 NT 0.2 0.2 0.2 0..2 ' 0.2 0.2 0.2 0.2 711.2 NSR 500.1 1902.8 2039.6 519.8 679.6 454.7 931.7 493.0 47 NT 21 57 50 48 114 29 67 54 Individual Urinalysis Values DuPont-5386 831 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations___________________________ DuPont-5386 Animal Number QUAL COL CLAR Female, Group : II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 LIGHT NT LIGHT MEDIUM LIGHT MEDIUM LIGHT MEDIUM MEDIUM LIGHT YELLOW NT YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW YELLOW CLEAR NT CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR CLEAR Female, Group ;: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 LIGHT LIGHT LIGHT NT LIGHT MEDIUM ' NT LIGHT MEDIUM NT YELLOW YELLOW YELLOW NT YELLOW YELLOW NT YELLOW YELLOW NT CLEAR CLEAR CLEAR NT CLEAR HAZY NT HAZY CLEAR NT Individual Urinalysis Values VOL UOSM mL mOsm/kg SG pH UGLU mg/dL KET mg/dL UBIL BLD 2.8 NT 3.5 2.6 7.9 3.2 15.4 1.0 1.2 9.0 11.0 4.8 4.9 QNS 7.9 3.3 QNS 9.0 2.8 QNS 1123 NT 1073 1589 894 1094 369 QNS QNS 668 1.036 NT 1.035 1.049 1.027 1.036 1.014 1.076 1.070 1.021 495 951 1042 QNS 594 1704 QNS 476 1617 QNS 1.018 1.029 1.033 NT 1.019 1.052 NT 1.017 1.048 NT 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE NT NT NT NT NT 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE NT NT NT NT NT 5.5 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.5 NEGATIVE 5 NEGATIVE NEGATIVE NT NT NT NT NT 6.0 NEGATIVE NEGATIVE NEGATIVE NEGATIVE 6.0 NEGATIVE 5 NEGATIVE NEGATIVE NT NT NT NT NT 832. Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number URO EU/dL UFLU ug UMTP mg/dL Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 0.2 3.6 NT NT 0.2 5.6 0.2 5.5 0.2 11.6 0.2 6.4 0.2 18.4 0.2 QNS 0.2 QNS 0.2 8.9 81 NT 29 57 26 428 7 185 80 90 Female, Group : VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 0.2 0.2 0.2 NT 0.2 0.2 ' NT 0.2 0.2 NT 30.3 30.0 49.7 QNS 40.0 38.9 QNS 73.6 44.2 QNS 12 100 25 QNS 23 49 QNS 228 48 QNS Individual Urinalysis Values SPEC FECAL CONTAMINATION OBSERVED Sample status: URINALYSIS TO BE RUN MANUALLY Sample status: URINALYSIS TO BE RUN MANUALLY VOLUME VOLUME DuPont-5386 833 Company Sanitized, Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations Animal Number UFLU ug Female, Group: II - 0 mg/kg - Day 181 643383 643384 643402 643465 643484 12.7 8.6 6.1 12.3 4.1 Female, Group: IV - 25 mg/kg - Day 181 643379 643391 643411 643437 643483 12.9 11.1 NT 23.8 QNS Female, Group: VI - 100 mg/kg - Day 181 643360 643373 643381 643382 643412 24.6 23.1 18 .-2 23.1 11.0 Female, Group: VIII - 250 mg/kg - Day 181 643329 643356 643388 643450 643487 17.2 28.7 QNS 47.7 23.6 Individual Urinalysis Values # DuPont-5386 834 Company Sanitized. Does not contain TSCA CBi H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group : I - 0 mg/kg - Day 44 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 NONE NONE NONE NONE NONE PEW NONE NONE FEW NONE 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 1-10 0 1-10 0 0 0 Male, Group: III - 25 mg/kg - Day 44 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE FEW FEW NONE NONE. NONE NONE NONE NONE NONE 00 00 00 0 >50 00 00 00 00 00 00 FEW FEW FEW FEW MODERATE FEW FEW FEW FEW MANY MODERATE FEW FEW NONE FEW FEW FEW MODERATE NONE MODERATE MANY MODERATE MODERATE MODERATE MANY MANY MANY MODERATE MANY MANY MODERATE MANY MANY MODERATE MODERATE MODERATE FEW MANY MANY MANY 3 2 1 2 0 1 1 0 3 0 2 1 2 2 1 2 0 1 1 1 # DuPont-5386 835 Company Sanitized. Does not contain TSCA CSf PI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations______________________________ Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: V - 100 mg/kg - Day 44 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NONE NONE FEW NONE NONE NONE FEW NONE NONE NONE 0 0 0 0 1-10 0 0 0 0 0 0 0 0 1-10 0 0 0 0 0 0 Male, Group: VII - 250 mg/kg - Day 44 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 NONE NONE FEW NONE NONE . NONE NONE FEW NONE FEW 0 1-10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 1-10 NONE FEW FEW FEW NONE FEW FEW FEW FEW MODERATE FEW MODERATE FEW FEW MODERATE NONE FEW NONE FEW FEW MANY MODERATE FEW MODERATE FEW FEW MANY MANY MANY MODERATE MANY FEW MODERATE FEW MODERATE MODERATE MODERATE MANY MODERATE MODERATE 0 1 1 1 1 0 1 0 1 2 2 2 1 FEW COARSELY GRANULAR CASTS 2 2 1 2 0 1 2 0 DuPont-5386 836 Company Saniti2ed. Doe5 nolc0,,(ain tsca ^ H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations # DuPont-5386 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: I - 0 mg/kg - Day 91 643143 FEW 0 0 few' FEW 643150 643165 643189 643204 643205 643235 643241 643288 643300 NONE FEW FEW FEW NONE FEW NONE NONE FEW 0 0 MODERATE FEW 0 1-10 FEW MANY 0 1-10 FEW MODERATE 0 0 FEW FEW 0 0 FEW FEW 0 0 FEW FEW 0 0 FEW FEW 0 0 FEW FEW 0 0 FEW FEW Male, Group : III - 25 mg/kg - Day 91 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 NONE NONE NONE FEW . NONE NONE NONE NONE NONE NONE 1-10 0 0 0 0 0 0 0 0 6 0 FEW 1-10 NONE 0 NONE >50 NONE 0 FEW o . FEW 0 FEW 0 FEW 0 FEW 0 MODERATE NONE MANY FEW FEW FEW MODERATE MODERATE MODERATE MODERATE FEW 2 Sample status : BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS 1 Sample status: BELOW RECOMMENDED VOLUME 2 1-MUCUS 3 1 1 Sample status: BELOW RECOMMENDED VOLUME 2 1 1 Sample status : BELOW RECOMMENDED VOLUME 1 Sample status : BELOW RECOMMENDED VOLUME 2 Sample status : BELOW RECOMMENDED VOLUME 3 3 1 Sample status: BELOW RECOMMENDED VOLUME 1 3 1 2 2 3 Sample status: BELOW RECOMMENDED VOLUME 837 Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations_____________________________ # DuPont-5386 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group : V - 100 mg/kg - Day 91 643175 643224 643243 643247 643250 643257 643275 643311 643314 643318 NSR FEW NONE FEW FEW FEW MODERATE FEW NONE NONE NT NT 0 1-10 00 00 00 0 1-10 00 00 00 00 Male, Group: VII - 250 mg/kg - Day 91 H 1 H O 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 FEW FEW FEW NONE NONE . NONE FEW NONE NONE NONE 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 NT NONE FEW FEW FEW FEW FEW FEW FEW FEW NONE NONE FEW FEW FEW FEW NONE FEW FEW MODERATE NT MANY MODERATE FEW MODERATE MANY MANY MODERATE MANY FEW MANY MANY FEW MODERATE FEW MODERATE MANY FEW MANY MODERATE NT 2 Sample status: BELOW RECOMMENDED VOLUME 2 2 1 Sample status : BELOW RECOMMENDED VOLUME 3 1-MUCUS 1 1 1 1 Sample status: BELOW RECOMMENDED VOLUME 3 1-MUCUS 1 2 3 1 2 3 1-MUCUS 1 2 2 838 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-<3eneration Reproductive Evaluations DuPont-5386 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Male, Group: I - 0 mg/kg - Day 125 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 FEW NONE FEW NONE FEW NONE FEW FEW FEW FEW 1-10 0 0 0 0 0 0 0 1-10 0 0 0 0 0 0 0 0 0 0 0 Male, Group: VII - 250 mg/kg - Day 125 643151 643165 643220 643225 NONE FEW FEW NONE 0 1-10 0 0 0 0 1-10 0 643234 643236 643258 643266 643296 643316 NONE ' FEW NONE NONE NONE NONE 0 1-10 1-10 0 0 0 1-10 1-10 0 0 0 0 NONE NONE NONE NONE NONE FEW FEW NONE FEW NONE NONE FEW MODERATE FEW MODERATE NONE FEW NONE NONE FEW MODERATE FEW MODERATE FEW MODERATE MODERATE MODERATE FEW MODERATE FEW MODERATE MODERATE MODERATE MODERATE MODERATE FEW MODERATE FEW FEW MANY 3 2 3 3 1-MUCUS 3 1-MUCUS 3 1 -MUCUS 2 3 3 1 -MUCUS 3 3 3 Sample status BELOW RECOMMENDED VOLUME 0 Sample status BELOW RECOMMENDED VOLUME 3 Sample status BELOW RECOMMENDED VOLUME; 2 -MUCUS; FEW COARSELY GRANULAR CASTS 2 Sample status BELOW RECOMMENDED VOLUME 3 1-MUCUS; MODERATE NUMBER OF RENAL EPITHELIAL CELLS 1 Sample status BELOW RECOMMENDED VOLUME 3 1 -MUCUS 2 2 Sample status BELOW RECOMMENDED VOLUME; 1-MUCUS 839 Company Sanitized. Does not contain TSCA CBi H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Female, Group: II - 0 mg/kg - Day 45 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 NONE FEW FEW FEW QNS FEW NONE FEW FEW FEW 0 0 1-10 0 NT 0 0 1-10 0 1-10 Female, Group: IV - 25 mg/kg - Day 45 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR NONE NONE FEW FEW FEW FEW NONE FEW NONE NT 0 0 0 0 1-10 0 0 1-10 0 0 MODERATE 0 NONE 0 FEW 0 NONE NT NT 0 FEW 0 MODERATE 0 MODERATE 0 NONE 0 FEW NT NT 0 FEW 0 MODERATE 0 FEW 0 FEW 0 NONE 0 MODERATE 0 FEW 0 FEW 0 MODERATE MANY FEW FEW MODERATE NT MODERATE MANY FEW FEW FEW NT MODERATE MODERATE MODERATE FEW FEW MODERATE MODERATE FEW MANY 0 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 NT 0 0 0 0 Sample status : BELOW RECOMMENDED VOLUME 1 -MUCUS 0 Sample status : BELOW RECOMMENDED VOLUME NT 0 0 0 0 0 0 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 840 Company Sanitized. Does not contain TSCA CBI # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations________________________ # DuPont-5386 Animal Number EPIT UWBC URBC Individual Urine Microscopic Values NCRY MICR SPER SPEC Female, Group: VI - 100 mg/kg - Day 45 643322 643323 643366 643367 643392 643409 643461 ,643462 643472 643489 FEW FEW FEW FEW NONE FEW NONE FEW NONE NONE 0 0 0 0 0 1-10 0 0 0 1-10 0 0 0 0 0 0 0 0 0 0 male. Group: VIII - 250 mg/kg - Day 45 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 NONE NONE FEW FEW NONE NONE NONE FEW NONE FEW 0 0 0 0 0 0 0 1-10 0 1-10 0 0 0 0 0 0 0 0 0 0 FEW NONE FEW MODERATE NONE FEW MODERATE NONE FEW FEW MODERATE MODERATE FEW MODERATE FEW MODERATE FEW FEW MODERATE NONE MODERATE MANY MODERATE MODERATE FEW NONE MODERATE MANY FEW FEW MODERATE MODERATE MODERATE MANY MODERATE MODERATE MANY MODERATE MODERATE FEW 0 0 0 0 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 0 0 0 0 0 0 0 0 0 0 0 0 841 Company Sanitized. Does not contain TSCA CBf 90-2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproductive Evaluations DuPont-5386 Animal Number EPIT UWBC URBC Female, Group : II - 0 mg/kg - Day 93 643354 643361 643362 643374 643398 643406 643436 643463 FEW FEW FEW FEW QNS QNS NONE FEW 00 00 0 1-10 00 NT NT NT NT 00 00 643477 FEW 0 0 643486 QNS NT NT Female, Group: IV - 25 mg/kg - Day 93 643321 643324 643364 643380 643389 643390 643396 643410 643433 643458 NSR FEW FEW FEW NONE * NONE FEW QNS FEW FEW NT 0 0 0 0 0 0 NT 0 0 NT 0 0 0 0 0 0 NT 0 0 Individual Urine Microscopic Values NCRY MICR SPER SPEC FEW MANY FEW MANY NONE MODERATE NONE MANY NT NT NT NT NONE MODERATE FEW FEW NONE MODERATE NT NT NT FEW FEW FEW NONE NONE NONE NT FEW NONE NT FEW MODERATE MANY FEW MODERATE MODERATE NT MODERATE MODERATE 0 0 1-MUCUS 0 1 -MUCUS 0 Sample status : BELOW RECOMMENDED VOLUME; 1-MUCUS NT NT 0 Sample status BELOW RECOMMENDED VOLUME 0 Sample status BELOW RECOMMENDED VOLUME; FEW COARSELY GRANULAR CASTS 0 Sample status: BELOW RECOMMENDED VOLUME NT NT 0 0 1 -MUCUS 0 2 -MUCUS 0 Sample status: BELOW RECOMMENDED VOLUME 0 Sample status: BELOW RECOMMENDED VOLUME; 1-MUCUS 0 Sample status: BELOW RECOMMENDED VOLUME; 1 -MUCUS NT 0 1 -MUCUS 0 Sample status: BELOW RECOMMENDED VOLUME 842 Company Sanitized. Does not contain TSCA CBt H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number EPIT UWBC URBC Female, Group: VI - 100 mg/kg - Day 93 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 FEW FEW FEW FEW FEW FEW FEW FEW FEW NONE 00 00 00 00 0 1-10 00 00 00 00 0 1-10 Female, Group: VIII - 250 mg/kg - Day 93 643332 643340 643341 643359 643370 643404 643408 643435 643446 643466 FEW NSR NONE FEW FEW FEW ' FEW FEW NONE FEW 0 NT 0 0 0 0 0 0 0 0 0 NT 0 0 0 0 0 0 0 0 Individual Urine Microscopic Values NCRY MICR SPER SPEC NONE NONE NONE NONE NONE NONE NONE FEW NONE NONE FEW MODERATE MODERATE MODERATE FEW MANY MODERATE MODERATE FEW MODERATE NONE NT NONE NONE NONE NONE NONE NONE NONE NONE FEW NT MODERATE MODERATE FEW FEW FEW MANY MODERATE MODERATE 0 Sample status: BELOW RECOMMENDED VOLUME ; 1-MUCUS 0 2 -MUCUS 0 1-MUCUS 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status: BELOW RECOMMENDED VOLUME 0 Sample status: BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status: BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME ; 1-MUCUS 0 1 -MUCUS 0 1 -MUCUS NT 0 2 -MUCUS 0 1-MUCUS 0 1-MUCUS 0 1-MUCUS 0 0 1-MUCUS 0 0 1-MUCUS 843 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproductive Evaluations DuPont-5386 Animal Number EPIT UWBC URBC Female, Group: II - 0 mg/kg - Day 125 643330 643336 643377 643387 643405 643415 643425 643426 643448 643453 FEW NSR FEW FEW FEW NONE NONE FEW FEW NONE 1-10 NT 1-10 0 1-10 0 0 1-10 1-10 1-10 0 NT 0 0 0 0 0 0 0 0 Female, Group: VIII - 250 mg/kg - Day 125 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 FEW FEW FEW QNS FEW FEW ' QNS NONE FEW QNS 0 1-10 1-10 NT 1-10 1-10 NT 0 1-10 NT 0 0 0 NT 0 0 NT 0 0 NT Individual Urine Microscopic Values NCRY MICR SPER SPEC FEW NT FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW NT FEW FEW NT FEW FEW NT FEW NT FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW FEW NT FEW FEW NT FEW FEW NT 0 Sample status : BELOW RECOMMENDED VOLUME NT 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 Sample status : BELOW RECOMMENDED VOLUME 0 Sample status : BELOW RECOMMENDED VOLUME 0 0 0 0 NT 0 0 Sample status : BELOW RECOMMENDED VOLUME NT 0 0 Sample status : BELOW RECOMMENDED VOLUME NT 844 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX L INDIVIDUAL HEPATIC BETA-OXIDATION ACTIVITY 845 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 10-Day Time Point Group NAunmimbaelr (nBmetoai-/Omxinid/matgiopnroRtaetien) I 645904 645905 645906 645907 645908 6.8 4.6 3.3 6.1 2.8 m 645909 645910 645911 645912 645913 7.1 8.2 7.5 11.1 10.6 V 645914 645915 645916 645917 645918 9.1 12.3 8.7 8.2 14.3 VII 645919 17.7 645920 645921 17.1 9.3 645922 - 17.4 645923 20.5 846 Company Sanitized. Does not contain TSCA CB1 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 90-Day Time Point Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRtaetien) I 643241 643300 643143 643205 643235 6.0 5.8 2.9 6.4 4.6 m 643173 643290 643272 643292 643228 15.7 9.1 6.7 16.2 17.2 V 643250 643243 643311 643318 643247 20.8 20.9 18.4 20.9 22.5 VII 643194 643252 643260 643315 643215 32.2 35.7 54.5 51.6 48.5 847 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 36-Day Recovery Time Point Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRtaetien) I 643237 643226 643195 643246 643253 12.4 9.1 6.0 9.7 5.5 vn 643225 643296 643258 643316 643220 27.8 26.8 34.5 34.4 26.4 848 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Male Rats At The 92-Day Recovery Time Point Group NAunmimbaelr Beta-Oxidation Rate (nmol/min/mg protein) I 643145 643210 643232 643265 643268 8.7 10.0 7.9 8.6 6.4 vn 643149 643152 643178 643283 643295 32.5 15.8 25.7 25.0 26.7 849 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 10-Day Time Point Group NAunmimbaelr (nBmeotal-/mOxinid/matgiopnroRtaetien) n 645926 645927 645928 645929 645930 6.6 7.2 7.7 7.0 12.0 IV 645931 645932 645933 645934 645935 9.9 8.6 4.7 6.0 9.4 VI 645936 645937 645938 645939 645940 13.6 13.4 11.9 17.8 12.3 vm 645941 645942 645943 645944 645945 18.7 21.8 20.9 18.7 25.4 850 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 90-Day Time Point Animal Group______ Number H 643477 643374 643406 643486 643361 IV 643390 643396 643380 643433 643389 VI 643322 . 643489 643409 643366 643367 VIE 643341 643370 643446 643435 643466 (nBmetoal-/Omxinid/matgiopnroRtaetien) 5.1 7.1 9.4 7.7 9.9 7.4 12.3 9.0 17.2 15.5 29.3 25.2 32.2 24.4 23.3 39.3 24.5 30.4 32.9 * 21.4 851 Company Sanitized. Does not contain TSCACBi H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 36-Day Recovery Time Point Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRtaetien) n 643405 643425 643448 643426 643415 10.5 11.5 9.5 8.4 8.3 Vffl 643347 643456 643423 643345 645551 18.9 14.8 20.2 21.1 24.6 852 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5386 Individual Hepatic Beta-Oxidation Activity In Female Rats At The 92-Day Recovery Time Point Group NAunmimbaelr (nBmetoal-/Omxinid/matgiopnroRtaetien) n 643383 643384 643402 643465 643484 19.2 15.2 19.0 19.3 19.4 Vffl 643329 643365 643388 643450 643487 35.9 34.3 27.9 31.2 29.1 853 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: avSaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations DuPont-5386 APPENDIX M INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS % % ------------------------------------------------------------------------- 854 Company Sanitized. Does not contain TSCA CBI H90-2-D45a1y6G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS o n . m v E X P O S U R E EVALUATION DuPont-5386 ANIMAL 1 FBW 1 BRAIN I ADRENAL GLANDS 1(Gms) (Gms) %FBW 1 (Gms) %FBW %BRAIN 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 512.40 470.00 586.60 601.50 570.80 563.80 622.00 612 90 584.20 575.00 2.079 0.4057 2.080 0.4426 2.155 0.3674 2.165 0.3599 2.089 0.3660 2.142 0.3799 2.223 0.3574 2.145 0.3500 2.121 0.3631 1.982 0.3447 0.053 0.0103 2.5493 0.049 0.0104 2.3558 0.048 0.0082 2.2274 0.061 0.0101 2.8176 0.068 0.0119 3.2551 0.072 0.0128 3.3613 0.047 0.0076 2.1143 0.045 0.0073 2.0979 0.050 0.0086 2.3574 0.061 0.0106 3.0777 Mean 569.92 2.118 0.3737 __S_.__D_.______ --46.423 -- 0.065 0.0296 0.055 0.0098 2.6214 0.009 0.0018 0.4747 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.368 0.2670 65.801 1.442 0.3068 69.327 1.793 0.3057 83.202 1.487 0.2472 68.684 1.687 0.2956 80.756 1.698 0.3012 79.272 1.756 0.2823 78.992 1.804 0.2943 84.103 1.545 0.2645 72.843 1.477 0.2569 74.521 1.606 0.2821 75.750 0.160 0.0217 6.4413 HEART (Gms) %FBW %BRAIN 1.491 0.2910 71.717 1.455 0.3096 69.952 1.804 0.3075 83.712 1.797 0.2988 83.002 1.967 0.3446 94.160 1.764 0.3129 82.353 1.830 0.2942 82.321 1.663 0.2713 77.529 1.701 0.2912 80.198 1.668 0.2901 84.157 1.714 0.3011 80.910 0.155 0.0195 6.8226 KIDNEYS (Gms) %FBW %BRAIN 3.529 0.6887 169.75 3.684 0.7838 177.12 4.020 0.6853 186.54 4.200 0.6983 194.00 3.443 0.6032 164.82 4.429 0.7856 206.77 4.172 0.6707 187.67 3.804 0.6207 177.34 3.667 0.6277 172.89 3.765 0.6548 189.96 3.871 0.6819 182.69 0.321 0.0625 12.662 Group : III - 25 mg/kg/day Sex :MALES ANIMAL FBW I BRAIN (Gms) I(Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 504.40 516.40 543.80 677.90 485.90 628.90 518.20 548.90 526.70 611.20 2.042 0.4048 2.086 0.4040 2.110 0.3880 2.319 0.3421 2.147 0.4419 2.312 0.3676 2.123 0.4097 1.986 0.3618 2.278 0.4325 2.210 0.3616 0.064 0.0127 3.1342 0.059 0.0114 2.8284 0.058 0.0107 2.7488 0.065 0.0096 2.8029 0.056 0.0115 2.6083 0.064 0.0102 2.7682 0.072 0.0139 3.3914 0.049 0.0089 2.4673 0.044 0.0084 1.9315 0.070 0.0115 3.1674 S.D. 556.23 2.161 0.3914 62.229 0.115 0.0328 0.060 0.0109 2.7848 0.009 0.0017 0.4083 EPIDIDYMIDES I HEART (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN 1.460 0.2895 71.499 1.461 0.2829 70.038 1.332 0.2449 63.128 1.527 0.2253 65.847 1.697 0.3492 79.041 1.771 0.2816 76.600 1.434 0.2767 67.546 1.400 0.2551 70.493 1.499 0.2846 65.803 1.496 0.2448 67.692 1.508 0.2735 69.769 1 0.133 0.0343 4.9518 1.536 0.3045 75.220 1.951 0.3778 93.528 1.515 0.2786 71.801 1.955 0.2884 84.304 1.692 0.3482 78.808 1.779 0.2829 76.946 1.545 0.2981 72.774 1.845 0.3361 92.900 1.628 0.3091 71.466 1.665 0.2724 75.339 1.711 0.3096 79.309 0.165 0.0342 8.2378 KIDNEYS (Gms) %FBW %BRAIN 3.920 0.7772 191.97 3.892 0.7537 186.58 4.435 0.8156 210.19 4.830 0.7125 208.28 3.761 0.7740 175.17 4.623 0.7351 199.96 3.627 0.6999 170.84 3.968 0.7229 199.80 4.474 0.8494 196.40 4.077 0.6670 184.48 4.161 0.7507 192.37 0.402 0.0550 13.143 FBW - Final Body Weight 855 Company Sanitized. Does not contain TSCA CEH dSt> H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations______________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION DuPont-5386 -oup : V - 100 mg/kg/day Sex :MALES ANIMAL FBW I BRAIN (Gms) (Gms) %FBW ADRE (Gms) UIDS %BRAIN 643224 643243 643247 643250 643257 643275 643311 643314 643318 478.10 533.20 544.30 470.60 499.60 532.90 506.70 498.60 567.00 2.080 0.4351 2.065 0.3873 2.054 0.3774 1.991 0.4231 2.076 0.4155 1.948 0.3655 1.999 0.3945 2.191 0.4394 2.239 0.3949 0.049 0.0102 2.3558 0.051 0.0096 2.4697 0.066 0.0121 3.2132 0.041 0.0087 2.0593 0.043 0.0086 2.0713 0.058 0.0109 2.9774 0.045 0.0089 2.2511 0.055 0.0110 2.5103 0.057 0.0101 2.5458 Mean S.D. 514.56 2.071 0.4036 31.860 0.093 0.0259 0.052 0.008 2.4949 0.3873 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.517 0.3173 72.933 1.346 0.2524 65.182 1.499 0.2754 72.980 1.382 0.2937 69.412 1.424 0.2850 68.593 1.293 0.2426 66.376 1.523 0.3006 76.188 1.557 0.3123 71.063 1.338 0.2360 59.759 1.431 0.2795 69.165 0.096 0.0300 4.9268 HEART 1 KIDNEYS (Gms) %FBW %BRAIN (Gms) %FBW %BRAIN 1.552 0.3246 74.615 1.473 0.2763 71.332 1.746 0.3208 85.005 1.341 0.2850 67.353 1.423 0.2848 68.545 1.659 0.3113 85.164 1.576 0.3110 78.839 1.413 0.2834 64.491 1.654 0.2917 73.872 3.840 0.8032 184.62 4.361 0.8179 211.19 4.304 0.7907 209.54 4.137 0.8791 207.79 3.672 0.7350 176.88 4.430 0.8313 227.41 4.279 0.8445 214.06 - 4.203 0.8430 191.83 4.463 0.7871 199.33 1.537 0.2988 74.358 0.135 0.0182 7.4153 4.188 0.268 Group : VII - 250 mg/kg/day Sex :MALES ANIMAL 1 FBW I BRAIN (Gms) (Gms) %FBW ADRE (Gms) 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 566.60 527.80 510.80 546.00 510.50 498.60 490.10 441.10 516.10 474.80 2.046 0.3611 2,178 0.4127 2.069 0.4051 2.170 0.3974 2.000 0.3918 2.193 0.4398 2.080 0.4244 1.930 0.4375 2.175 0.4214 2.139 0.4505 0.059 0.0104 0.055 0.0104 0.051 0.0100 0.050 0.00920.057 0.0112 0.052 0.0104 0.049 0.0100 0.040 0.0091 0.065 0.0126 0.067 0.0141 .8837 .5253 .4650 .3041 .8500 .3712 .3558 .0725 .9885 .1323 Mean S .D. 508.24 2.098 0.4142 35.490 0.088 0.0266 0.055 0.008 2.5948 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.468 0.2591 71.750 1.422 0.2694 65.289 1.448 0.2835 69.985 1.542 0.2824 71.060 1.686 0.3303 84.300 1.431 0.2870 65.253 1.484 0.3028 71.346 1.271 0.2881 65.855 1.540 0.2984 70.805 1.383 0.2913 64.656 1.468 0.2892 70.030 0.110 0.0193 5.7887 (Gms) HEART %FBW %BRAIN 1.716 0.3029 83.871 1.440 0.2728 66.116 1.468 0.2874 70.952 1.710 0.3132 78.802 1.421 0.2784 71.050 1.578 0.3165 71.956 1.515 0.3091 72.837 1.352 0.3065 70.052 1.430 0.2771 65.747 1.478 0.3113 69.098 1.511 0.2975 72.048 0.122 0.0168 5.5358 KIDNEYS (Gms) %FBW %BRAIN 5.024 0.8867 245.55 4.847 0.9183 222.54 4.156 0.8136 200.87 4.806 0.8802 221.47 5.102 0.9994 255.10 4.572 0.9170 208.48 4.824 0.9843 231.92 3.841 0.8708 199.02 5.006 0.9700 230.16 4.082 0.8597 190.84 4.626 0.9100 220.60 0.445 0.0596 20.883 FBW - Final Body Weight 856 Company Sanitized Does not contain TSCA CBI  H90-2-D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : I - 0 mg/kg/day Sex :MALES I ANIMAL (Gms) LIVER 1 SPLEEN %FBW %BRAIN |(Gms) %FBW %BRAIN 643143 643150 643185 643189 643204 643205 643235 643241 643288 643300 Mean S.D. 12.027 2.3472 578.50 12.058 2.5655 579.71 15.885 2.7080 737.12 17.971 2.9877 830.07 14.869 2.6049 711.78 16.314 2.8936 761.62 19.863 3.1934 893.52 16.844 2.7482 785.27 14.978 2.5638 706.18 15.334 2.6668 773.66 15.614 2.7279 735.74 2.409 0.2426 99.373 0.763 0.1489 36.700 0.771 0.1640 37.067 0.788 0.1343 36.566 0.857 0.1425 39.584 0.938 0.1643 44.902 1.002 0.1777 46.779 0.969 0.1558 43.590 0.720 0.1175 33.566 0.745 0.1275 35.125 0.703 0.1223 35.469 0.826 0.1455 38.935 0.109 0.0201 4.5784 TESTES I THYMUS (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 3.281 0.6403 157.82 3.861 0.8215 185.63 3.654 0.6229 169.56 3.693 0.6140 170.58 3.704 0.6489 177.31 3.624 0.6428 169.19 4.302 0.6916 193.52 3.675 0.5996 171.33 3.307 0.5661 155.92 3.187 0.5543 160.80 0.505 0.0986 24.291 0.390 0.0830 18.750 0.508 0.0866 23.573 0.597 0.0993 27.575 0.352 0.0617 16.850 0.277 0.0491 12.932 0.594 0.0955 26.721 0.512 0.0835 23.869 0.539 0.0923 25.413 0.206 0.0358 10.394 3.629 0.6402 171.16 0.323 0.0754 11.887 0.448 0.0785 21.037 0.135 0.0221 5.9719 Group : III - 25 mg/kg/day Sex :MALES ANIMAL j (Gms) LIVER I SPLEEN %FBW %BRAIN |(Gms) %FBW %BRAIN 643173 643179 643180 643228 643240 643264 643272 643290 643292 643308 14.493 2.8733 709.75 15.519 3.0052 743.96 16.875 3.1032 799.76 20.448 3.0164 881.76 13.780 2.8360 641.83 19.596 3.1159 847.58 15.966 3.0810 752.05 17.459 3.1807 879.10 15.715 2.9837 689.86 18.920 3.0955 856.11 0.510 0.1011 24.976 0.685 0.1326 32.838 0.569 0.1046 26.967 0.779 0.1149 33.592 0.712 0.1465 33.163 1.071 0.1703 46.324 0.769 0.1484 36.222 0.820 0.1494 41.289 0.525 0.0997 23.047 0.900 0.1473 40.724 Mean S .D. 16.877 3.0291 780.18 2.210 0.1093 85.088 0.734 0.1315 33.914 0.175 0.0248 7.5143 TESTES (Gms) %FBW %BRAIN 3.142 0.6229 153.87 3.714 0.7192 178.04 3.168 0.5826 150.14 3.651 0.5386 157.44 3.591 0.7390 167.26 3.761 0.5980 162.67 2.928 0.5650 137.92 2.860 0.5210 144.01 3.989 0.7574 175.11 3.165 0.5178 143.21 3.397 0.6162 156.97 0.389 0.0910 13.696 THYMUS (Gms) %FBW %BRAIN 0.233 0.0462 11.410 0.443 0.0858 21.237 0.307 0.0565 14.550 0.514 0.0758 22.165 0.448 0.0922 20.866 0.281 0.0447 12.154 0.391 0.0755 18.417 0.453 0.0825 22.810 0.251 0.0477 11.018 0.408 0.0668 18.462 0.373 0.0674 17.309 0.098 0.0176 4.6311 FBW - Final Body Weight # DuPont-5386 857 COmpany Sarl,t 20di Des not contain TSCA CBl H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction E v a l u a t i o n s ______________ ___________________ _________________D__u_P_o_n_t-_5_3_8_6 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS cnD on.rav EXPOSURE EVALUATION Group : V - 100 mg/kg/day Sex :MALES ANIMAL j (Gms) LIVER I SPLEEN %FBW %BRAIN | (Gms) %FBW %BRAIN 643224 643243 643247 643250 643257 643275 643311 643314 643318 S.D. 18.368 3.8419 883.08 23.501 4.4075 1138.1 23.174 4.2576 1128.2 17.434 3.7046 875.64 19.589 3.9209 943.59 22.561 4.2336 1158.2 22.345 4.4099 1117.8 20.904 4.1925 954.08 21.877 3.8584 977.09 21.084 4.0919 1019.5 2.167 0.2633 115.06 0.687 0.1437 33.029 0.843 0.1581 40.823 0.919 0.1688 44.742 0.677 0.1439 34.003 0.754 0.1509 36.320 0.743 0.1394 38.142 0.887 0.1751 44.372 0.857 0.1719 39.115 0.818 0.1443 36.534 0.798 0.1551 38.564 0.087 0.0138 4.1546 (Gms) TESTES %FBW %BRAIN I |(Gms) THYMUS %FBW %BRAIN 3.605 0.7540 173.32 3.331 0.6247 161.31 3.793 0.6969 184.66 3.386 0.7195 170.07 3.497 0.7000 168.45 3.526 0.6617 181.01 3.499 0.6905 175.04 3.653 0.7327 166.73 3.693 0.6513 164.94 0.242 0.0506 11.635 0.500 0.0938 24.213 0.429 0.0788 20.886 0.367 0.0780 18.433 0.383 0.0767 18.449 0.309 0.0580 15.862 0.443. 0.0874 22.161 0.217 0.0435 9.9042 0.459 0.0810 20.500 3.554 0.6924 171.72 0.147 0.0410 7.5837 0.372 0.0720 18.005 0.098 0.0172 4.7634 Group : VII - 250 mg/kg/day Sex :MALES ANIMAL I __ ________1--(Gms) LIVER %FBW %BRAIN --;-- - - 643174 643193 643194 643201 643215 643252 643259 643260 643298 643315 28.144 4.9672 1375.6 24.347 4.6129 1117.9 24.229 4.7433 1171.0 26.508 4.8549 1221.6 27.373 5.3620 1368.7 27.181 5.4515 1239.4 25.986 5.3022 1249.3 23.001 5.2145 1191.8 26.542 5.1428 1220.3 22.063 4.6468 1031.5 Mean S.D. 25.537 5.0298 1218.7 2.018 0.3066 103.65 SPLEEN (Gms) %FBW 0.737 0.1301 36.022 0.627 0.1188 28.788 0.698 0.1366 33.736 0.884 0.1619 40.737 0.691 0.1354 34.550 0.705 0.1414 32.148 0.616 0.1257 29.615 0.683 0.1548 35.389 0.790 0.1531 36.322 0.703 0.1481 32.866 0.713 0.1406 34.017 0.078 0.0138 3.4685 TESTES (Gms) %FBW %BRAIN THYMUS (Gms) %FBW %BRAIN 3.576 0.6311 174.78 3.692 0.6995 169.51 3.386 0.6629 163.65 3.975 0.7280 183.18 3.517 0.6889 175.85 3.522 0.7064 160.60 3.709 0.7568 178.32 3.021 0.6849 156.53 3.925 0.7605 180.46 3.168 0.6672 148.11 NW 0.392 0.0743 17.998 0.463 0.0906 22.378 0.455 0.0833 20.968 0.331 0.0648 16.550 0.270 0.0542 12.312 0.445 0.0908 21.394 0.310 0.0703 16.062 0.295 0.0572 13.563 0.276 0.0581 12.903 3.549 0.6986 169.10 0.360 0.0715 17.125 0.302 0.0411 11.503 I 0.080 0.0142 3.8158 FBW - Final Body Weight Company Sanitized. Does not contain TSCA CBI #; # # H90-2-D45a1y6G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction E v a l u a t i o n s __________________________________________________DuPont --5^: INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : I - 0 mg/kg/day Sex :MALES I ANIMAL FBW I BRAIN I ADRENAL GLANDS (Gms) I(Gms) %FBW | (Gms) %FBW %BRAIN 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 419.20 648.90 597.40 590.10 516.00 677.20 635.30 650.30 656.10 516.00 Mean S.D. 590.65 82.533 2.104 0.5019 2.210 0.3406 2.204 0.3689 2.082 0.3528 1.996 0.3868 2.216 0.3272 2.066 0.3252 2.369 0.3643 2.158 0.3289 2.105 0.4079 2.151 0.3705 0.105 0.0536 0.053 0.0126 2.5190 0.062 0.0096 2.8054 0.056 0.0094 2.5408 0.046 0.0078 2.2094 0.039 0.0076 1.9539 0.065 0.0096 2.9332 0.053 0.0083 2.5653 0.068 0.0105 2.8704 0.046 0.0070 2.1316 0.062 0.0120 2.9454 0.055 0.0094 2.5475 0.009 0.0019 0.3526 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.332 0.3177 63.308 1.617 0.2492 73.167 1.551 0.2596 70.372 1.204 0.2040 57.829 1.539 0.2983 77.104 1.843 0.2722 83.168 1.171 0.1843 56.680 1.506 0.2316 63.571 1.683 0.2565 77.989 1.659 0.3215 78.812 1.511 0.2595 70.200 0.215 0.0454 9.3499 (Gms) HEART %FBW %BRAIN 1.463 0.3490 69.534 1.749 0.2695 79.140 1.986 0.3324 90.109 1.592 0.2698 76.465 2.236 0.4333 112.02 1.803 0.2662 81.363 1.787 0.2813 86.496 1.95Q 0.2999 82.313 1.756 0.2676 81.372 1.547 0.2998 73.492 1.787 .3069 83.231 0.229 .0528 11.737 KIDNEYS (Gms) %FBW %BRAIN 3.616 0.8626 171.86 4.075 0.6280 184.39 3.509 0.5874 159.21 3.752 0.6358 180.21 3.582 0.6942 179.46 4.190 0.6187 189.08 4.268 0.6718 206.58 4.300 0.6612 181.51 4.642 0.7075 215.11 3.284 0.6364 156.01 3.922 0.6704 182.34 0.434 0.0765 18.447 Group mq/kq/day Sex MALES ANIMAL FBW BRAIN (Gms) %FBW ADRENAL GLANDS (Gms) %FBW %BRAIN 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 472.60 533.80 490.80 558.10 541.30 542.00 515.70 562.60 602.20 560.70 Mean S.D. 537.98 37.554 2.188 0.4630 2.081 0.3898 2.048 0.4173 2.154 0.3860 2.208 0.4079 2.101 0.3876 2.230 0.4324 2.202 0.3914 2.175 0.3612 2.096 0.3738 2.148 0.4010 0.062 0.0300 0.051 0.0108 2.3309 0.054 0.0101 2.5949 0.054 0.0110 2.6367 0.035 0.0063 1.6249 0.060 0.0111 2.7174 0.061 0.0113 2.9034 0.053 0.0103 2.3767 0.052 0.0092 2.3615 0.062 0.0103 2.8506 0.057 0.0102 2.7195 0.054 0.0101 2.5116 0.008 0.0015 0.3706 EPIDIDYMIDES (Gms) %FBW %BRAIN 1.592 0.3369 72.761 1.555 0.2913 74.724 0.998 0.2033 48.730 5.417 0.9706 251.49 1.551 0.2865 70.245 1.563 0.2884 74.393 1.296 0.2513 58.117 1.812 0.3221 82.289 1.519 0.2522 69.839 1.683 0.3002 80.296 1.899 0.3503 88.288 1.256 0.2213 58.207 (Gms) HEART %FBW %BRAIN 1.507 0.3189 68 .876 1.830 0.3428 87 .938 1.671 0.3405 81 .592 1 751 0.3137 81 .291 1.734 0.3203 78 .533 1.696 0.3129 80 .723 1.622 0.3145 72 .735 1.690 0.3004 76 .748 1.713 0.2845 78 .759 1.817 0.3241 86 .689 1.703 0.094 0.0172 5.7690 KIDNEYS (Gms) %FBW %BRAIN 4.220 0.8929 192.87 4.466 0.8366 214.61 3.747 0.7634 182.96 5.110 0.9156 237.23 4.870 0.8997 220.56 4.634 0.8550 220.56 3.869 0.7502 173.50 4.715 0.8381 214.12 4.923 0.8175 226.34 4.706 0.8393 224.52 4.526 0.8408 210.73 0.451 0.0545 20.637 FBW - Final Body Weight 859 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations________ ______________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION J IGroup : I - 0 mg/kg/day Sex :MALES ANIMAL LIVER (Gms) %FBW %BRAIN |(Gms) SPLEEN %FBW %BRAIN I | (Gms) TESTES %FBW %BRAIN 1 |(Gms) THYMUS %FBW %BRAIN 1 | 643162 643172 643195 643226 643237 643246 643253 643262 643303 643304 10.852 2.5887 515.78 16.681 2.5707 754.80 15.905 2.6624 721.64 14.428 2.4450 692.99 15.272 2.9597 765.13 17.881 2.6404 806.90 16.290 2.5641 788.48 16.405 2.5227 692.49 16.410 2.5011 760.43 12.941 2.5079 614.77 0.462 0.1102 21.958 0.800 0.1233 36.199 0.728 0.1219 33.031 0.841 0.1425 40.394 0.819 0.1587 41.032 1.063 0.1570 47.969 0.897 0.1412 43.417 0.770 0.1184 32.503 0.738 0.1125 34.198 0.788 0.1527 37.435 3.272 0.7805 155.51 3.515 0.5417 159.05 3.395 0.5683 154.04 2.870 0.4864 137.85 3.690 0.7151 184.87 4.391 0.6484 198.15 3.141 0.4944 152.03 3.762 0.5785 158.80 2.994 0.4563 138.74 3.009 0.5831 142.95 0.277 0.0661 13.165 0.502 0.0774 22.715 0.367 0.0614 16.652 0.247 0.0419 11.864 0.204 0.0395 10.220 0.283 0.0418 12.771 0.253 0.0398 12.246 0.371 0.0571 15.661 0.373 0.0569 17.285 0.160 0.0310 7.6009 S.D. 15.307 2.5963 711.34 2.068 0.1435 88.595 0.791 0.1338 36.814 0.151 0.0187 7.1480 3.404 0.5853 158.20 0.459 0.1032 19.427 0.304 0.0513 14.018 0.100 0.0146 4.2375 Group : VII - 250 mg/kg/day Sex J ANIMAL LIVER (Gms) %FBW %BRAIN MALES (Gms) SPLEEN %FBW %BRAIN 643151 643165 643220 643225 643234 643236 643258 643266 643296 643316 15.674 3.3165 716.36 18.089 3.3887 869.25 15.720 3.2029 767.58 20.721 3.7128 961.98 20.334 3.7565 920.92 19.595 3.6153 932.6516.997 3.2959 762.20 18.904 3.3601 858.49 20.729 3.4422 953.06 23.195 4.1368 1106.6 0.893 0.1890 40.814 0.763 0.1429 36.665 0.820 0.1671 40.039 1.063 0.1905 49.350 0.873 0.1613 39.538 0.722 0.1332 34.365 0.706 0.1369 31.659 0.664 0.1180 30.154 0.815 0.1353 37.471 0.956 0.1705 45.611 S.D. 18.996 3.5228 884.91 2.412 0.2835 116.19 0.828 0.1545 38.567 0.123 0.0248 5.9162 TESTES (Gms) %FBW %BRAIN 3.897 0.8246 178.11 3.749 0.7023 180.15 1.983 0.4040 96.826 3.798 0.6805 176.32 3.434 0.6344 155.53 3.553 0.6555 169.11 3.002 0.5821 134.62 3.636 0.6463 165.12 3.027 0.5027 139.17 .3.457 0.6166 164.93 3.354 0.6249 155.99 0.567 0.1136 25.953 THYMUS 1 (Gms) %FBW %BRAIN | 0.226 0.0478 10.329 0.219 0.0410 10.524 0.346 0.0705 16.895 0.318 0.0570 14.763 0.344 0.0636 15.580 0.139 0.0256 6.6159 0.372 0.0721 16.682 0.271 0.0482 12.307 0.317 0.0526 14.575 0.398 0.0710 18.989 0.295 0.0549 13.726 0.080 0.0150 3.7426 FBW - Final Body Weight DuPont-5386 860 Company Sanitized. Does not contain TSCA C8 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS pno t'u o e 't?-MONTH RECOVERY EVALUATION Group : I - 0 mg/kg/day Sex :MALES ANIMAL j FBW KIDNEYS (Gms) (Gms) %FBW 643145 643210 643232 643265 643268 557.80 606.20 617.50 576.90 687.80 3.665 0.6570 4.696 0.7747 4.159 0.6735 4.148 0.7190 4.453 0.6474 Mean S.D. 609.24 49.853 4.224 0.6943 0.387 0.0526 1 LIVER (Gms) %FBW 15.836 2.8390 16.402 2.7057 16.538 2.6782 16.530 2.8653 19.012 2.7642 16.864 2.7705 1.235 0.0813 TESTES (Gras) %FBW 3.207 0.5749 4.177 0.6890 3.512 0.5687 3.643 0.6315 4.148 0.6031 3.737 0.6135 0.419 0.0491 THYROID GLAND (Gms) %FBW 0.023 0.0041 0.022 0.0036 0.026 0.0042 0.029 0.0050 0.023 0.0033 0.025 0.0041 0.003 0.0006 Group : III - 25 mg/kg/day Sex :MALES ANIMAL j FBW KIDNEYS (Gms) (Gms) %FBW 643202 643293 643305 643306 643310 523.60 620.20 644.70 514.80 618.70 4.108 0.7846 4.571 0.7370 4.531 0.7028 3.090 0.6002 4.-329 0.6997 S.D. 584.40 60.488 4.126 0.7049 0.608 0.0678 LIVER (Gms) %FBW 14.756 2.8182 15.455 2.4919 16.640 2.5810 13.123 2.5491 14.482 2.3407 14.891 2.5562 1.293= 0.1731 TESTES (Gms) %FBW 4.385 0.8375 3.564 0.5747 3.967 0.6153 3.244 0.6301 3.412 0.5515 3.714 0.6418 0.461 0.1138 THYROID GLAND (Gms) %FBW 0.018 0.0034 0.026 0.0042 0.023 0.0036 0.015 0.0029 0.024 0.0039 0.021 0.0036 0.005 0.0005 FBW - Final Body Weight O DuPont-5386 861 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR MALE RATS nucTr.mTcn FOR THREE-MONTH RECOVERY EVALUATION Group : V - 100 mg/kg/day Sex :MALES ANIMAL j FBW I KIDNEYS (Gms) (Gms) %FBW 643159 643169 643181 643206 643286 608.80 555.30 729.90 534.30 558.50 Mean S.D. 597.36 78.983 4.267 0.7009 4.278 0.7704 4.386 0.6009 4.186 0.7835 3.895 0.6974 4.202 0.7106 0.186 0.0728 (Gms) LIVER %FBW 18.278 3.0023 15.727 2.8322 19.257 2.6383 17.415 3.2594 15.356 2.7495 17.207 2.8963 1.659 0.2425 Group : VII - 250 mg/kg/day Sex :MALES I ANIMAL FBW KIDNEYS (Gms) (Gms) %FBW 643149 643152 643178 643283 643295 619.10 770.50 457.70 575.20 522.50 4.260 0.6881 5.835 0.7573 4.031 0.8807 4(092 0.7114 4.236 0.8107 Mean S.D. 589.00 118.00 4.491 0.7696 0.758 0.0778 LIVER (Gms) %FBW 20.372 3.2906 23.913 3.1036 14.293 3.1228 18.797 3.2679 15.313 2.9307 18.538 3.1431 3.897 0.1453 TESTES (Gms) %FBW 4.082 0.6705 3.187 0.5739 4.697 0.6435 3.756 0.7030 3.081 0.5517 3.761 0.6285 0.665 0.0641 TESTES (Gms) %FBW 3.958 0. 4.128 0. 3.183 0. 3.459 0. 3.805 0 3.707 0 0.383 0 THYROID GLAND (Gms) %FBW 0.022 0.0036 0.026 0.0047 0.019 0.0026 0.028 0.0052 0.029 0.0052 0.025 0.0043 0.004 0.0011 THYROID GLAND (Gms) %FBW 0.021 0.0034 0.026 0.0034 0.020 0.0044 0.023 0.0040 0.028 0.0054 0.024 0.0041 0.003 0.0008 FBW - Final Body Weight DuPont-5386 862 corta'n T S C A C B I CompanySa**!**?? H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-GenCration Reproduction Evaluations DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES I ANIMAL FBW BRAIN (Gms) (Gms) %FBW ._-- ------ -- ------ 643354 280.00 643361 373.00 1.777 .6346 1.911 .5123 643362 303.50 1.906 .6280 643374 643398 643406 643436 643463 301.20 290.20 260.40 304.20 331.30 1.799 2.032 1.871 1.811 1.946 .5973 .7002 .7185 .5953 .5874 643477 285.40 1.871 .6556 643486 245.30 1.915 .7807 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.061 Q.080 0.056 0.055 0.079 0.055 0.065 0.079 0.062 0.057 0218 3 .4328 0214 4.1863 0185 2.9381 ,0183 3.0573 ,0272 3.8878 .0211 2.9396 .0214 3.5892 .0238 4.0596 .0217 3.3137 .0232 2.9765 Mean S.D. 297.45 35.815 1.884 0.6410 0.076 0.0766 0.065 0.0218 3.4381 0.010 0.0026 0.4765 HEART (Gms) %FBW %BRAIN 0.865 0.3089 48.678 1.137 0.3048 59.498 1.085 0.3575 56.925 1.036 0.3440 57.588 1.103 0.3801 54.281 0.887 0.3406 47.408 1.033 0.3396 57.040 1.098 0.3314 56.423 0.960 0.3364 51.309 0.831 0.3388 43.394 1.004 0.3382 53.255 0.110 0.0216 5.2999 KIDNEYS (Gms) %FBW %BRAIN 2.005 0.7161 112.83 2.400 0.6434 125.59 1.979 0.6521 103.83 2.068 0.6866 114.95 2.107 0.7261 103.69 1.778 0.6828 95.029 2.098 0.6897 115.85 2.342 0.7069 120.35 2.171 0.7607 116.03 1.740 0.7093 90.862 2.069 0.6974 109.90 0.211 0.0346 11.163 (Gms) LIVER %FBW %BRAIN 7.697 2.7489 433.15 9.431 2.5284 493.51 8.409 2.7707 441.19 9.159 3.0408 509.12 8.431 2.9052 414.91 7.670 2.9455 409.94 9.145 3.0062 504.97 9.612 2.9013 493.94 7.794 2.7309 416.57 6.941 2.8296 362.45 8.429 2.8408 447.97 0.893 0.1525 49.753 Group : IV - 25 mg 1I ANIMAL FBW I BRAIN (Gms) 1(Gms). %FBW I ADRENAL GLANDS I (Gms) %FBW %BRAIN 643324 643364 643380 643389 643390 643396 643410 643433 643458 290.60 288.70 321.10 280.50 274.30 340.40 312.50 337.10 287.80 2.136 0.7350 1.848 0.6401 2.078 0.6472 2.061 0.7348 1.934 0.7051 1.989 0.5843 2.039 0.6525 1.829 0.5426 1.953 0.6786 0.057 0.0196 0.070 0.0242 0.061 0.0190 0.073 0.0260 0.060 0.0219 0.085 0.0250 0.065 0.0208 0.057 0.0169 0.063 0.0219 .6685 .7879 .9355 .5420 .1024 .2735 .1878 .1165 .2258 Mean S.D. 303.67 1.985 0.6578 24.735 0.104 0.0649 0.066 0.0217 3.3155 0.009 0.0030 0.4828 (Gms) HEART %FBW %BRAIN 1.047 0.3603 49.017 0.883 0.3059 47.781 1.058 0.3295 50.914 1.062 0.3786 51.528 1.088 0.3966 56.256 1.276 0.3749 64.153 1.069 0.3421 52.428 1.716 0.5090 93.822 1.048 0.3641 53.661 1.139 0.3734 57.729 0.238 0.0578 14.364 KIDNEYS (Gms) %FBW %BRAIN 2.267 0.7801 106.13 1.828 0.6332 98.918 2.513 0.7826 120.93 2.315 0.8253 112.32 2.276 0.8297 117.68 2.758 0.8102 138.66 2.639 0.8445 129.43 2.058 0.6105 112.52 2.439 0.8475 124.88 2.344 0.7737 117.94 0.286 0.0895 12.149 LIVER (Gms) %FBW %BRAIN 8.814 3.0330 412.64 8.713 3.0180 471.48 9.167 2.8549 441.15 9.652 3.4410 468.32 8.436 3.0755 436.19 12.620 3.7074 634.49 8.619 2.7581 422.71 8.877 2.6333 485.35 8.711 3.0268 446.03 9.290 3.0609 468.71 1.298 0.3323 66.482 FBW - Final Body Weight 863 Company Sanitized. Does not contain TSCA CBI 00 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________ 0 DuPont-5386 INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : VJ - 100 mg/kg/day Sex :FEMALES I ANIMAL 1 FBW (Gms) 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 282.00 270.40 303.80 289.50 259.00 272.30 313.20 311.80 254.60 307.50 BRAIN (Gms) %FBW 1.887 0.6691 1.936 0.7160 1.977 0.6508 1.919 0.6629 1.895 0.7317 1.877 0.6893 1.982 0.6328 1.918 0.6151 1.716 0.6740 2.035 0.6618 Mean S.D. 286.41 22.003 1.914 0.6703 0.085 0.0353 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.053 0.0188 2.8087 0.080 0.0296 4.1322 0.063 0.0207 3.1866 0.074 0.0256 3.8562 0.070 0.0270 3.6939 0.049 0.0180 2.6105 0.072 0.0230 3.6327 0.065 0.0208 3.3889 0.069 0.0271 4.0210 0.060 0.0195 2.9484 0.066 0.0230 3.4279 0.010 0.0041 0.5255 (Gms) HEART %FBW %BRAIN 1.035 0.3670 54.849 1.015 0.3754 52.428 0.995 0.3275 50.329 1.046 0.3613 54.508 0.894 0.3452 47.177 1.031 0.3786 54.928 1.094 0.3493 55.197 1.058 0.3393 55.162 0.919 0.3610 53.555 1.031 0.3353 50.663 1.012 0.3540 52.879 0.062 0.0173 2.7060 KIDNEYS (Gms) %FBW %BRAIN 2.257 0.8004 119.61 2.321 0.8584 119.89 2.226 0.7327 112.59 2.348 0.8111 122.36 2.008 0.7753 105.96 2.250 0.8263 119.87 2.782 0.8883 140.36 2.603 0.8348 135.71 2.136 0.8390 124.48 2.359 0.7672 115.92 2.329 0.8133 121.68 0.222 0.0462 10.153 (Gms) LIVER I %FBW %BRAIN 1 10.226 3.6262 541.92 9.397 3.4752 485.38 10.124 3.3325 512.09 10.624 3.6698 553.62 8.750 3.3784 461.74 10.217 3.7521 544.33 11.802 3.7682 595.46 11.178 3.5850 582.79 9.439 3.7074 550.06 11.184 3.6371 549.58 10.294 3.5932 537.70 0.938 0.1513 41.017 Group : VIII - 250 mg/kg/day Sex :FEMALES I ANIMAL 1 643332 643341 643359 643370 643404 643408 643435 643446 643466 FBW (Gms) 263.50 287.20 335.10 317.30 249.30 290.10 233.90 295.80 279.20 BRAIN (Gms) %FBW 1.904 0.7226 1.888 0.6574 1.978 0.5903 1.930 0.6083 2.026 0.8127 1.859 0.6408 1.797 0.7683 2.001 0.6765 2.111 0.7561 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.064 0.0243 3.3613 0.061 0.0212 3.2309 0.071 0.0212 3.5895 0.071 0.0224 3.6788 0.078 0.0313 3.8500 0.051 0.0176 2.7434 0.064 0.0274 3.5615 0.060 0.0203 2.9985 0.073 0.0261 3.4581 Mean S.D. 283.49 1.944 0.6925 31.745 0.095 0.0765 0.066 0.0235 3.3858 0.008 0.0042 0.3475 (Gms) HEART %FBW %BRAIN 1.000 0.3795 52.521 0.885 0.3081 46.875 1.193 0.3560 60.313 1.089 0.3432 56.425 1.017 0.4079 50.197 1.016 0.3502 54.653 0.877 0.3749 48.804 1.059 0.3580 52.924 1.130 0.4047 53.529 1.030 0.3647 52.916 0.104 0.0312 4.0525 KIDNEYS (Gms) %FBW %BRAIN 2.313 0.8778 121.48 2.474 0.8614 131.04 2.878 0.8588 145.50 2.689 0.8475 139.33 3.075 1.2335 151.78 2.404 0.8287 129.32 2.329 0.9957 129.60 2.736 0.9249 136.73 2.550 0.9133 120.80 2.605 0.9269 133.95 0.260 0.1256 10.399 (Gms) LIVER 1 %FBW %BRAIN 1 12.742 4.8357 669.22 12.486 4.3475 661.33 14.952 4.4620 755.92 14.597 4.6004 756.32 12.396 4.9723 611.85 11.243 3.8756 604.79 10.064 4.3027 560.04 12.746 4.3090 636.98 12.022 4.3059 569.49 12.583 4.4457 647.33 1.509 0.3254 71.762 FBW - Final Body Weight 864 Company Sanitized. Does not contain TSCACBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES ANIMAL 1 OVARIES I (Gms) %FBW %BRAIN |(Gms) SPLEEN %FBW %BRAIN 643354 643361 643362 643374 643398 643406 643436 643463 643477 643486 S.D. 0.133 0.0475 7.4845 0.127 0.0340 6.6457 0.117 0.0386 6.1385 0.071 0.0236 3.9466 0.157 0.0541 7.7264 0.118 0.0453 6.3068 0.141 0.0464 7.7858 0.132 0.0398 6.7831 0.076 0.0266 4.0620 0.083 0.0338 4.3342 0.116 0.0390 6.1214 0.029 0.0096 1.4950 0.534 0.1907 30.051 0.640 0.1716 33.490 0.515 0.1697 27.020 0.557 0.1849 30.962 0.605 0.2085 29.774 0.457 0.1755 24.425 0.384 0.1262 21.204 0.611 0.1844 31.398 0.421 0.1475 22.501 0.336 0.1370 17.546 0.506 0.1696 26.837 0.103 0.0256 5.2041 THYMUS (Gms) %FBW %BRAIN 0.188 0.0671 10.580 0.511 0.1370 26.740 0.398 0.1311 20.881 0.333 0.1106 18.510 0.329 0.1134 16.191 0.243 0.0933 12.988 0.256 0.0842 14.136 0.256 0.0773 13.155 0.320 0.1121 17.103 0.144 0.0587 7.5196 0.298 0.0985 15.780 0.106 0.0266 5.4588 UTERUS (Gms) %FBW %BRAIN 0.484 0.1729 27.237 0.634 0.1700 33.176 0.514 0.1694 26.967 0.675 0.2241 37.521 0.516 0.1778 25.394 0.570 0.2189 30.465 0.588 0.1933 32.468 0.557 0.1681 28.623 0.551 0.1931 29.449 0.693 0.2825 36.188 0.578 0.1970 30.749 0.070 0.0363 4.0262 Group : IV - 25 mg/kg/day Sex :FEMALES IANIMAL OVARIES I (Gms) %FBW %BRAIN (Gms) SPLEEN %FBW %BRAIN 643324 643364 643380 643389 643390 643396 643410 643433 643458 0.118 0.0406 5.5243 0.105 0.0364 5.6818 0.146 0.0455 7.0260 0.135 0.0481 6.5502 0.109 0.0397 5.6360 0.098 0.0288 4.9271 0.151 0.0483 7.4056 0.117 0.0347 6.3969 0.120 0.0417 6.1444 0.537 0.1848 25.140 0.496 0.1718 26.840 0.473 0.1473 22.762 0.493 0.1758 23.920 0.445 0.1622 23.009 0.615 0.1807 30.920 0.565 0.1808 27.710 0.486 0.1442 26.572 0.445 0.1546 22.785 Mean S.D. 0.122 0.0404 6.1436 0.018 0.0065 0.7854 0.506 0.1669 25.518 0.056 0.0153 2.7589 THYMUS (Gms) %FBW %BRAIN 0.269 0.0926 12.594 0.171 0.0592 9.2532 0.347 0.1081 16.699 0.306 0.1091 14.847 0.309 0.1127 15.977 0.231 0.0679 11.614 0.388 0.1242 19.029 0.441 0.1308 24.112 0.348 0.1209 17.819 0.312 0.1028 15.771 0.082 0.0249 4.4157 UTERUS (Gms) %FBW %BRAIN 0.959 0.3300 44.897 0.503 0.1742 27.219 0.549 0.1710 26.420 0.413 0.1472 20.039 0.929 0.3387 48.035 0.653 0.1918 32.831 0.978 0.3130 47.965 0.454 0.1347 24.822 0.513 0.1782 26.267 0.661 0.2199 33.166 0.230 0.0825 10.887 DuPont-5386 FBW - Final Body weight 865 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR 90-DAY EXPOSURE EVALUATION Group : VI - 100 mg/kg/day Sex :FEMALES ANIMAL J OVARIES (Gms) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN 643322 643323 643366 643367 643392 643409 643461 643462 643472 643489 Mean S.D. 0.113 0.0401 5.9883 0.149 0.0551 7.6963 0.157 0.0517 7.9413 0.103 0.0356 5.3674 0.128 0.0494 6.7546 0.133 0.0488 7.0858 0.150 0.0479 7.5681 0.120 0.0385 6.2565 0.121 0.0475 7.0513 0.113 0.0367 5.5528 0.129 0.0451 6.7262 0.018 0.0068 0.9037 0.436 0.1546 23.105 0.662 0.2448 34.194 0.507 0.1669 25.645 0.427 0.1475 22.251 0.398 0.1537 21.003 0.423 0.1553 22.536 0.642 0.2050 32.392 0.652 0.2091 33.994 0.445 0.1748 25.932 0.479 0.1558 23.538 0.507 0.1767 26.459 0.104 0.0322 5.1141 THYMUS 1 UTERUS (Gms) %FBW %BRAIN |(Gras) %FBW %BRAIN 0.344 0.1220 18.230 . 0.288 0.1065 14.876 0.249 0.0820 12.595 0.395 0.1364 20.584 0.201 0.0776 10.607 0.329 0.1208 17.528 0.304 0.0971 15.338 0.314 0.1007 16.371 0.211 0.0829 12.296 0.215 0.0699 10.565 0.539 0.1911 28 .564 0.743 0.2748 38 .378 0.604 0.1988 30 .551 0.647 0.2235 33 .715 0.498 0.1923 26 .280 0.386 0.1418 20 .565 0.639 0.2040 32 .240 0.657 .2107 34 .254 0.603 0.2368 35 .140 0.491 0.1597 24 .128 0.285 0.0996 14.899 0.065 0.0219 3.3660 0.581 0.2034 30.382 0.103 0.0375 5.4954 Group : VIII - 250 mg/kg/day Sex FEMALES ANIMAL OVARIES (Gms) %FBW %BRAIN SPLEEN (Gms) %FBW %BRAIN 643332 643341 643359 643370 643404 643408 643435 643446 643466 0.102 0.0387 5.3571 0.103 0.0359 5.4555 0.140 0.0418 7.0779 0.093 0.0293 4.8187 0.139 0.0558 6.8608. 0.117 0.0403 6.2937 0.103 0.0440 5.7318 0.104 0.0352 5.1974 0.100 0.0358 4.7371 0.424 0.1609 22.269 0.424 0.1476'22.458 0.645 0.1925 32.609 0.540 0.1702 27.979 0.528 0.2118 26.061 0.555 0.1913 29.855 0.470 0.2009 26.155 0.617 0.2086 30.835 0.528 0.1891 25.012 Mean S.D. 0.111 0.0396 5.7256 0.017 0.0074 0.8461 0.526 0.1859 27.026 0.077 0.0219 3.6026 THYMUS I UTERUS (Gms) %FBW %BRAIN |(Gms) %FBW %BRAIN 0.209 0.0793 10.977 0.258 0.0898 13.665 0.505 0.1507 25.531 0.284 0.0895 14.715 0.221 0.0886 10.908 0.302 0.1041 16.245 0.298 0.1274 16.583 0.202 0.0683 10.095 0.281 0.1006 13.311 0.917 0.3480 48.162 0.850 0.2960 45.021 0.702 0.2095 35.490 0.429 0.1352 22.228 0.367 0.1472 18.115 0.486 0.1675 26.143 0.828 0.3540 46.077 0.656 0.2218 32.784 0.745 0.2668 35.291 0.284 0.0998 14.670 0.091 0.0253 4.6861 0.664 0.2384 34.368 0.196 0.0826 10.751 FBW - Final Body Weight # DuPont-5386 866 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex FEMALES I ANIMAL 1 FBW (Gms) 643330 643377 643387 643405 643415 643425 643426 643448 643453 278 80 356.00 334.20 375.20 414.90 365.00 376.00 329.20 348.70 BRAIN (Gms) %FBW 1.784 0.6399 1.893 0.5317 2.004 0.5996 1.915 0.5104 1.940 0.4676 1.982 0.5430 1.870 0.4973 2.009 0.6103 1.955 0.5607 Mean S.D. 353.11 1.928 0.5512 37.832 0.072 0.0568 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.053 0.0190 2.9709 0.066 0.0185 3.4865 0.077 0.0230 3.8423 0.085 0.0227 4.4386 0.087 0.0210 4.4845 0.055 0.0151 2.7750 0.055 0.0146 2.9412 0.062 0.0188 3.0861 0.059 0.0169 3.0179 0.067 0.0189 3.4492 0.013 0.0030 0.6582 (Gms) HEART %FBW %BRAIN 1.207 0.4329 67.657 1.151 0.3233 60.803 1.125 0.3366 56.138 1.117 0.2977 58.329 1.331 0.3208 68.608 1.202 0.3293 60.646 1.331 0.3540 71.176 1.026 0.3117 51.070 1.079 0.3094 55.192 1.174 0.3351 61.069 0.105 0.0402 6.7915 KIDNEYS (Gms) %FBW %BRAIN 2.209 0.7923 123.82 2.706 0.7601 142.95 2.396 0.7169 119.56 2.264 0.6034 118.22 2.843 0.6852 146.55 2.429 0.6655 122.55 2.243 0.5965 119.95 2.187 0.6643 108.86 2.654 0.7611 135.75 2.437 0.6939 126.47 0.242 0.0694 12.508 DuPont-5386 (Gms) LIVER I %FBW %BRAIN 1 8.689 3.1166 487.05 11.099 3.1177 586.32 8.682 2.5978 433.23 10.447 2.7844 545.54 13.441 3.2396 692.84 9.244 2.5326 466.40 10.833 2.8811 579.30 7.944 2.4131 395.42 10.507 3.0132 537.44 10.098 2.8551 524.84 1.672 0.2918 90.512 Group : VIII - 250 mg/kg/day Sex :FEMALES I ANIMAL 1 FBW (Gms) 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 313.00 263.40 286.30 352.20 294.70 365.40 312.70 326.60 272.00 299.50 BRAIN (Gms) %FBW 1.892 0.6045 1.839 0.6982 1.53 0.6472 1.782 0.5060 1.932 0.6556 1.891 0.5175 2.024 0.6473 2.114 0.6473 1.879 0.6908 1.912 0.6384 ADRENAL GLANDS (Gms) %FBW %BRAIN 0.091 0.0291 4.8097 0.074 0.0281 4.0239 0.075 0.0262 4.0475 0.065 0.0185 3.6476 0.094 0.0319 4.8654 0.061 0.0167 3.2258 . 0.072 0.0230 3.5573 0.075 0.0230 3.5478 0.069 0.0254 3.6722 0.068 0.0227 3.5565 Mean S.D. 308.58 32.733 1.912 0.6253 0.095 0.0653 0.074 0.0244 3.8954 0.011 0.0047 0.5504 (Gms) HEART %FBW %BRAIN 1.145 0.3658 60.518 0.948 0.3599 51.550 1.028 0.3591 55.478 l.iii 0.3154 62.346 1.165 0.3953 60.300 1.058 0.2895 55.949 1.209 0.3866 59.733 1.122 0.3435 53.075 1.090 0.4007 58.010 0.951 0.3175 49.738 1.083 0.3534 56.670 0.087 0.0369 4.2230 KIDNEYS (Gms) %FBW %BRAIN 2.393 0.7645 126.48 2.320 0.8808 126.16 2.282 0.7971 123.15 2.222 0.6309 124.69 2.311 0.7842 119.62 2.699 0.7386 142.73 3.458 1.1059 170.85 2.888 0.8843 136.61 2.092 0.7691 111.34 2.408 0.8040 125.94 2.507 0.8159 130.76 0.406 0.1245 16.478 (Gms) LIVER 1 %FBW %BRAIN 1 9.195 2.9377 485.99 8.942 3.3948 486.24 8.176 2.8557 441.23 10.438 2.9637 585.75 11.520 3.9091 596.27 10.501 2.8738 555.31 11.910 3.8088 588.44 11.658 3.5695 551.47 8.467 3.1129 450.61 9.126 3.0471 477.30 9.993 3.2473 521.86 1.389 0.3953 59.782 FBW - Final Body Weight 867 Company SanHteed. Does noicontain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction E v a l u a t i o n s ________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR ONE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES ANIMAL OVARIES (Gms) %FBW BRAIN SPLEEN (Gms) %FBW %BRAIN 643330 643377 643387 643405 643415 643425 643426 643448 643453 0.067 0.0240 3.7556 0.078 0.0219 4.1204 0.127 0.0380 6.3373 0.134 0.0357 6.9974 0.108 0.0260 5.5670 0.127 0.0348 6.4077 0.100 0.0266 5.3476 0.148 0.0450 7.3668 0.150 0.0430 7.6726 0.575 0.2062 32.231 0.581 0.1632 30.692 0.474 0.1418 23.653 0.744 0.1983 38.851 0.608 0.1465 31.340 0.460 0.1260 23.209 0.545 0.1449 29.144 0.524 0.1592 26.083 0.595 0.1706 30.435 Mean S.D. 0.115 0.0328 5.9525 0.029 0.0085 1.3740 0.567 0.1619 29.515 0.084 0.0264 4.8238 THYMUS (Gms) %FBW 0.232 0.0832 13.004 0.280 0.0787 14.791 0.164 0.0491 8.1836 0.404 0.1077 21.097 0.382 0.0921 19.691 0.244 0.0668 12.311 0.263 0.0699 14.064 0.207 0.0629 10.304 0.239 0.0685 12.225 0.268 0.0754 0.078 0.0173 UTERUS (Gms) %FBW %BRAIN 0.612 0.2195 34.305 0.689 0.1935 36.397 1.025 0.3067 51.148 0.505 0.1346 26.371 0.805 0.1940 41.495 0.669 0.1833 33.754 0.736 0.1957 39.358 0.625 0.1899 31.110 0.569 0.1632 29.105 0.693 0.1978 35.894 0.153 0.0472 7.4421 Group : VIII - 250 mg/kg/day Sex :FEMALES ANIMAL I OVARIES I SPLEEN (Gms) %FBW %BRAIN | (Gms) %FBW %BRAIN 643345 643347 643351 643358 643423 643441 643444 643456 643474 643481 Mean S.D. 0.135 0.0431 7.1353 0.114 0.0433 6.1990 0.095 0.0332 5.1268 0.109 0.0309 6.1167 0.078 0.0265 4.0373 0.132 0.0361 6.9804 0.116 0.0371 5.7312 0.135 0.0413 6.3860 0.134 0.0493 7.1315 0.129 0.0431 6.7469 0.118 0.0384 6.1591 0.019 0.0069 0.9846 0.505 0.1613 26.691 0.449 0.1705 24.415 0.394 0.1376 21.263 0.451 0.1281 25.309 0.882 0.2993 45.652 0.611 0.1672 32.311 0.516 0.1650 25.494 0.593 0.1816 28.051 0.503 0.1849 26.770 0.470 0.1569 24.582 0.537 0.1752 28.054 0.138 0.0470 6.8055 THYMUS (Gms) %FBW %BRAIN 0.283 0.0904 14.958 0.143 0.0543 7.7760 0 176 0.0615 9.4981 0.187 0.0531 10.494 0.298 0.1011 15.424 0.227 0.0621 12.004 0.238 0.0761 11.759 0.259 0.0793 12.252 0.260 0.0956 13.837 0.208 0.0694 10.879 0.228 0.049 UTERUS (Gms) %FBW %BRAIN 0.592 0.1891 31 .290 0.710 0.2696 38 .608 0.643 0.2246 34 .700 0.639 0.1814 35 .859 0.719 0.2440 37 .215 1.224 0.3350 64 .728 0.700 0.2239 34 .585 0.615 0.1883 29 .092 0.586 0.2154 31 .187 0.463 0.1546 24 .215 0.689 0.2226 36.148 0.202 0.0516 10.899 FBW - Final Body Weight DuPont-5386 868 Company Sanitized. Does not contain TSCA CBf ## H90--2D4a5y16G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____________________________________________________ INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Group : II - 0 mg/kg/day Sex :FEMALES J ANIMAL FBW KIDNEYS (Gms) (Gms) %FBW LIVER (Gms) %FBW THYROID GLAND (Gms) %FBW 643383 643384 643402 643465 643484 312.70 315.00 294.90 345.90 294.60 2.305 0.7371 2.085 0.6619 2.222 0.7535 2.541 0.7346 2.451 0.8320 10.212 3.2657 8.456 2.6844 7.891 2.6758 10.237 2.9595 8.697 2.9521 0.018 0.0058 0.016 0.0051 0.017 0.0058 0.017 0.0049 0.015 0.0051 Mean S.D. 312.62 20.928 2.321 0.7438 0.181 0.0606 9.099 2.9075 1.069 0.2431 0.017 0.0053 0.001 0.0004 # DuPont-5386 Group : IV - 25 mg/kg/day Sex :FEMALES J ANIMAL FBW KIDNEYS (Gms) (Gms) %FBW. LIVER (Gms) %FBW 643379 643391 643437 643483 368.10 326.80 343.10 299.70 2.367 0.6430 2.262 0.6922 2.505 0.7301 2.614 0.8722 10.036 2.7264 9.563 2.9263 9.046 2.6365 8.265 2.7578 Mean S.D. 334.43 28.713 2.437 0.7344 0.-154 0.0986 9.228 2.7617 0.758 0.1211 THYROID GLAND (Gms) %FBW 0.014 0.0038 0.017 0.0052 0.018 0.0052 0.024 0.0080 0.018 0.0056 0.004 0.0018 I 1 FBW - Final Body Weight 869 Company Sanitized. Does not contain TSCA CBi ## H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL FINAL BODY AND ORGAN WEIGHTS FOR FEMALE RATS DESIGNATED FOR THREE-MONTH RECOVERY EVALUATION Group : VI I1 ANIMAL - 100 mg/kg/day Sex :FEMALES FBW KIDNEYS (Gms) (Gms) %FBW (Gms) LIVER %FBW 643360 643373 6433B1 643382 643412 277.70 356.80 328.10. 286.10 327.20 2.342 0.8434 2.963 0.8304 2.302 0.7016 2.511 0.8777 2.221 0.6788 8.488 3.0565 11.626 3.2584 9.562 2.9144 9.100 3.1807 9.309 2.8450 Mean S.D. 315.10 32.764 2.468 0.7664 0.296 0.0898 9.617 3.0510 1.191 0.1739 THYROID GLAND (Gms) %FBW 0.019 0.0068 0.019 0.0053 0.016 0.0049 0.025 0.0087 0.017 0.0052 0.019 0.0062 0.003 0.0016 I 1 Group : VIII - 250 mg/kg/day Sex :FEMALES I ANIMAL 1 643329 643356 643388 643450 643487 FBW (Gms) 368.90 341.10 286.10 429.70 312.00 KIDNEYS (Gms) %FBW 3.198 0.8669 2.497 0.7320 2.248 0.7857 3,379 0.7864 2.200 0.7051 LIVER (Gms) %FBW 11.876 3.2193 11.657 3.4175 9.323 3.2587 12.632 2.9397 9.954 3.1904 Mean S.D. 347.56 55.421 2.704 0.7752 0.549 0.0621 11.088 3.2051 1.390 0.1723 THYROID GLAND (Gms) %FBW 0.017 0.0046 0.015 0.0044 0.021 0.0073 0.020 0.0047 0.024 0.0077 0.019 0.0057 0.004 0.0016 1 1 FBW - Final Body Weight # DuPont-5386 870 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations DuPont-5386 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS 871 CompanySanitized. Does notcontain TSCACBl # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643143 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, 'SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, 643143 Continued on the next page .... # DuPont-5386 872 Company Sanitized. Does not contain TSCA CBI # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643143 Continued from previous page Histopathology : No Microscopic Abnormality Observed : TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643145 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. 643145 Continued on the next page .... # DuPont-5386 873 Company Sanitized. Does not contain TSCA CBf # H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643145 Continued from previous page Histopathology : KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, mild. EPITHELIUM, 643150 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643150 Continued on the next page .... # DuPont-5386 874 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref 643150 Microscopic & Macroscopic Findings Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 643162 No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC ' NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, 'BONE MARROW, NOSE, MANDIBLE Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643162 Continued on the next page .... # DuPont-5386 875 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations____________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643162 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : ODONTODYSPLASIA, moderate. minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643172 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643172 Continued on the next page .... 876 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643172 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. . No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643185 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643185 Continued on the next page .... # DuPont-5386 877 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref 643185 Microscopic & Macroscopic Findings Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE m DuPont-5386 878. Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643189 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. 643189 Continued on the next page .... DuPont-5386 879 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AITO MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643189 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643195 ' Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643195 Continued on the next page .... 880 Company Sanitized. Does not contain TSCA CBf ' 9H0--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations______________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643195 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643204 . Terminal Sacrifice Killed on Day : 91 . Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643204 Continued on the next page .... DuPont-5386 881 Company Sanitized. Does not contain TSCA CBl # H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643204 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 882 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643205 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. EYE(S) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. 643205 Continued on the next page .... DuPont-5386 883 Company Sanitized. Does not oontain TSCA CBl H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643205 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643210 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643210 Continued on the next page .... DuPont-5386 884 Company Sanitized. Does not contain TSCA CB H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643210 Continued from previous page Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE 643226 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal, is signed off from necropsy Gross Pathology : TESTES : DEFORMITY, RIGHT. EPIDIDYMIDES : SMALL, RIGHT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND 643226 Continued on the next page .... DuPont-5386 885 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643226 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL, mild. No Microscopic Abnormality Observed : EPIDIDYMIDES, NOSE, MANDIBLE # DuPont-5386 886 Company Sanitized. Does not contain TSCA CBl H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643232 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, . 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE DuPont-5386 887 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations ___________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643235 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ALTERATION, COLLOID, minimal. 643235 Continued on the next page .... 888 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643235 Continued from previous page Histopathology : No Microscopic Abnormality Observed : KIDNEYS, LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643237 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643237 Continued on the next page .... DuPont-5386 889 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643237 Continued from previous page Histopathology : ' LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643241 'Terminal Sacrifice Killed on Day : .91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643241 Continued on the next page .... DuPont-5386 890 Company Sanitized Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643241 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE DuPont-5386 891 Company Sanitized. Does not contain TSCA CBl H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643246 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 892 Company Sanitized. Does not contain TSCA CBf H90--2D45a1y6G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males AAnniimmaall RReeff Microscopic & Macroscopic Findings 643253 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : TESTES : SMALL, LEFT. EPIDIDYMIDES : SMALL, LEFT. No Macroscopic Abnormality Observed : -LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : ., NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643253 Continued on the next page .... DuPont-5386 893 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643253 Continued from previous page Histopathology : TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL, severe. EPIDIDYMIDES : OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL, severe. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643262 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643262 Continued on the next page .... 894 Company Sanitized. Does not contain TSCA CB H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643262 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643265 Terminal Sacrifice Killed on Day : 181 ' Exposure Group : THREE-MONTH RECOVERY Animal is signed offfrom necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643265 Continued on the next page .... 895 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643265 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. No Microscopic Abnormality Observed : KIDNEYS, NOSE 643268 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, t t .17.t t m , PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643268 Continued on the next page .... t DuPont-5386 896 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643268 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM, mild. 643288 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643288 Continued on the next page .... DuPont-5386 897 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643288 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. PARATHYROID GLANDS : NOT PRESENT. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM,.COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 898 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvuagbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations _____________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643300 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, . PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. 643300 Continued on the next page .... DuPont-5386 8 " Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643300 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW, NOSE, MANDIBLE 643303 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643303 Continued on the next page .... DuPont-5386 900 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643303 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 643304 Terminal Sacrifice Killed on Day : 125 . Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : SPLEEN : DEFORMITY. MANDIBULAR LYMPH NODE : DISCOLORATION, RED. THYMUS : SMALL. DuPont-5386 643304 Continued on the next page .... 901 Company Sanitized. Does not contain TSCA CBl # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : I - 0 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643304 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. MANDIBULAR LYMPH NODE : ERYTHROCYTOSIS/ERYTHROPHAGOCYTOSIS, SINUS, mild. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, SPLEEN, THYMUS, NOSE, MANDIBLE # DuPont-5386 902 Company Sanitized. Does not contain TSCA CBf H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_______________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643173 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 903 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643179 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. No Microscopic Abnormality Observed : KIDNEYS, THYROID GLAND, NOSE, MANDIBLE DuPont-5386 904 company Sanltbed. Does noconiato TSCACBI #. # H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643180 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE t DuPont-5386 CompanySaniiteed. Does no,contain tsca cbi  H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643202 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : TESTES : SMALL, SOFT, RIGHT. No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH 'NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM, minimal. SCHWANNOMA [B]. [B]=BENIGN, [M]=MALIGNANT DuPont-5386 906 Company Sanfiized. Does no!co n ta in TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643228 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE, MANDIBLE DuPont-5386 907 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643240 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 908 Company Sanitized. Does not contain TSCA CBI  H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643264 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE 909 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25. mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643272 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, - PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : LIVER, KIDNEYS, NOSE, MANDIBLE # DuPont-5386 910 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643290 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. . THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 911 Company Sanitized. Does no! contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643292 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, . 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE 912 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643293 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, . 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. DuPont-5386 913 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_____________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643305 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, .ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, severe.. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT, mild. DuPont-5386 914 feompany Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643306 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, - -PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE DuPont-5386 915 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxictistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643308 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 916 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : III - 25 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643310 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, "PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, mild. DuPont-5386 917 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643159 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ''PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION, AMELOBLASTS, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, minimal. FRACTURE/CALLUS, TOOTH. EPITHELIUM, 918 Company Sanitized. Does not contain TSCA CBI #/ # H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations_________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643169 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, .URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE # DuPont-5386 919 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations______________________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643175 Accidentally Killed Duration of dosing-days: 77 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, TAN, LEFT. No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, "SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. LUNGS : INFLAMMATION, GRANULOMATOUS, severe. HEART : INFLAMMATION, SUBACUTE/CHRONIC, moderate. THYMUS : NOT PRESENT. 643175 Continued on the next page .... DuPont-5386 920 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643175 Continued from previous page Histopathology : PARATHYROID GLANDS : NOT PRESENT. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, moderate. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. TESTES : SPERMATID RETENTION, SEMINIFEROUS TUBULES, minimal. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, moderate. NOSE' : DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM, minimal. INFLAMMATION, SUBACUTE/CHRONIC, mild. NON-PROTOCOL TISSUE : Moderate, ABSCESS, SUBCUTIS. No Microscopic Abnormality Observed : SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, PITUITARY GLAND, THYROID GLAND, TRACHEA, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES, URINARY BLADDER, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM DuPont-5386 921 ComnanySabred. Does no!contain TSCACB! H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643181 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, EPITHELIUM, mild. INFLAMMATION, SUBACUTE/CHRONIC, NASOLACRIMAL DUCT, mild. DuPont-5386 922 Company Sanitized. Does not contain TSCA CBI # # #H90-2-D45a1y6G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643206 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE 923 mpmywmz&a. s'*eonfafn TSCACBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations__________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref 643224 Microscopic & Macroscopic Findings Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, .'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 TSCASanitized. Does not contain cat H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643243 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 925 Company Sanitized. Does notcontain TSCA CBI H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643247 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND,THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, `'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 926 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643250 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Hi stopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : KIDNEYS, NOSE, MANDIBLE DuPont-5386 927 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643257 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, -'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. FATTY CHANGE, MEDIAN CLEFT, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE # DuPont-5386 928 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643275 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. DuPont-5386 929 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643286 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, .'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. No Microscopic Abnormality Observed : NOSE DuPont-5386 930 Company Sanitized. Does not contain TSCA CBI 24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 rag/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643311 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. 643311 Continued on the next page .... DuPont-5386 931 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643311 Continued from previous page Histopathology : No Microscopic Abnormality Observed : MANDIBLE 643314 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No- Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. 643314 Continued on the next page .... DuPont-5386 932 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations___________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Rf Microscopic & Macroscopic Findings 643314 Continued from previous page Histopathology : THYROID GLAND : ALTERATION, COLLOID, mild. No Microscopic Abnormality Observed : NOSE, MANDIBLE 643318 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. 643318 Continued on the next page .... DuPont-5386 933 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtondiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : V - 100 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643318 Continued from previous page Histopathology : LIVER : FATTY CHANGE, CENTRILOBULAR,.minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. HYPERTROPHY, FOLLICULAR, minimal. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 934 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations_____________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643149 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' -PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. FATTY CHANGE, MEDIAN CLEFT, mild. KIDNEYS : CALCULUS\CALCULI, minimal. HYPERPLASIA, TRANSITIONAL CELL, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/SQUAMOUS METAPLASIA, RESPIRATORY, minimal. EPITHELIUM, DuPont-5386 935 Company Sanitized. Does not contain TSCA CBf H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643151 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ''PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FOCUS OF CELLULAR ALTERATION, BASOPHILIC, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 936 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643152 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, moderate. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. DuPont-5386 937 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250. mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643165 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE DuPont-5386 & f*m' -H*,n y CBr H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250. mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643174 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, CENTRILOBULAR, minimal. INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : HYDRONEPHROSIS, BILATERAL, minimal. HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. 643174 Continued on the next page .... DuPont-5386 939 Company SanWred. Does notcontain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc TinoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643174 Continued from previous page Histopathology MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, "PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643178 it Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643178 Continued on the next page DuPont-5386 940 Company Sanitized. Does not contato TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643178 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : . NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. 643193 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643193 Continued on the next page .... 941 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643193 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : . INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. LUNGS : INFLAMMATION, GRANULOMATOUS, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. EYE(S ) WITH OPTIC NERVE : FOLD/ROSETTE, RETINAL, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643193 Continued on the next page .... DuPont-5386 942 Company Sanitized. Does notcontain TSCA CBI m H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic Sc Macroscopic Findings 643193 Continued from previous page Histopathology : No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643194 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643194 Continued on the next page .... 943 DuPont-5386 m H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643194 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CNTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : .ALTERATION, COLLOID, severe. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW DuPont-5386 944 Company Sanitized. Does not contain TSCA CBf H90--2D4a5y16G: aSvuagbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643201 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, moderate. KIDNEYS : HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643201 Continued on the next page .... 945 tm * " e""w " TSC H90--2D4a5y16G: aSvuagbechSrtoundiyc iTnoRxiatistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643201 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643215 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643215 Continued on the next page .... DuPont-5386 946 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643215 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, mild. HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, mild. NOSE : . DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW # DuPont-5386 947 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643220 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : SEMINAL VESICLES : SMALL, LEFT. TESTES : SOFT, BILATERAL. EPIDIDYMIDES : DEFORMITY, LEFT. No" Macroscopic Abnormality Observed : LIVER, KIDNEYS,. LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, URINARY BLADDER, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. 643220 Continued on the next page # DuPont-5386 948 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250. mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643220 Continued from previous page Histopathology : TESTES : DEGENERATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, moderate. EPIDIDYMIDES : OLIGOSPERMIA/GERM CELL DEBRIS, UNILATERAL, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. 643225 No Microscopic Abnormality Observed : KIDNEYS, SEMINAL VESICLES, MANDIBLE Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643225 Continued on the next page .... DuPont-5386 949 Company Sanitized. Does not contain TSCA CBI H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643225 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. 643234 No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643234 Continued on the next page .... 950 Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations___________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643234 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal. NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : MANDIBLE 643236 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : THYMUS : SMALL. 643236 Continued on the next page .... 951 DuPont-5386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250. mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643236 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : THYMUS, MANDIBLE DuPont-5386 952 Company Sanitized. Does not contain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643252 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. PANCREAS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, mild. E Y E (S ) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. 643252 Continued on the next page .... 953 Company Sanitized. Does not contain TSCACBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643252 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, ''PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643258 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643258 Continued on the next page .... DuPont-5386 954 Company Sanitized. D oes not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643258 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 643259 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND 643259 Continued on the next page .... 955 Companysani**. D .no.containTSCAc a H90--2D4a5y16G:aSvaugbechSrtoundiyc iTnoRxiaciistywith One-Generation Reproduction Evaluations_________________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS DuPont-5386 Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings Animal Ref Microscopic & Macroscopic Findings 643259 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER' : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS', FOCAL, minimal. KIDNEYS : HYDRONEPHROSIS, UNILATERAL, minimal. HYPERTROPHY, TUBULAR, minimal. HEART : CARDIOMYOPATHY, minimal. PANCREAS : ATROPHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, minimal. ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643259 Continued on the next page .... 956 Company Sanitized. Does not contain TSCA CBJ H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations__________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643259 Continued from previous page Histopathology : No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643260 'Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE 643260 Continued on the next page .... DuPont-5386 957 Company Sanitized. Does notcontain TSCACBI #H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643260 Continued from previous page Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. NECROSIS, FOCAL, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, minimal. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. - 'HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW DuPont-5386 958. Company Sanitized. Does not contain TSCA CBI H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643266 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, "THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. No Microscopic Abnormality Observed : NOSE, MANDIBLE # DuPont-5386 959 Company Sanitized. Does notcontain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643283 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. NECROSIS, FOCAL, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, minimal. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. # DuPont-5386 Does no* contain TSCA C H H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations________________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643295 Terminal Sacrifice Killed on Day : 181 Exposure Group : THREE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : INFLAMMATION, SUBACUTE/CHRONIC, mild. DEGENERATION/NECROSIS, RESPIRATORY, EPITHELIUM, mild. DEGENERATION, AMELOBLASTS, minimal. 961 Company Sanitized. Does notcontain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations _______________________ _____________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643296 Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' 'PHARYNX/LARYNX, E Y E (S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. NOSE : DEGENERATION, AMELOBLASTS, minimal. No Microscopic Abnormality Observed : KIDNEYS, MANDIBLE 962 Company Sanitized. Does notcontain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643298 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy . Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, 'PHARYNX/LARYNX, EYE(S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, tJRINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE; minimal. HYPERTROPHY, TUBULAR, mild. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. NOSE : DEGENERATION, AMELOBLASTS, mild. MANDIBLE : DEGENERATION, AMELOBLASTS, mild. 643298 Continued on the next page .... # DuPont-5386 963 Company Sanitized. Does notcontain TSCA CBJ H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643298 Continued from previous page Histopathology No Microscopic Abnormality Observed : LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW 643309 Accidentally Killed Duration of dosing-days: 70 Exposure Group : REPRODUCTION Animal is signed off from necropsy Gross Pathology : LIVER : DISCOLORATION, MOTTLED, TAN. SMALL INTESTINE : DISTENDED WITH GAS, moderate. SALIVARY GLANDS : EDEMA. SKIN : STAIN, RED, FACE. PLEURAL CAVITY : FLUID, CLEAR, severe. 643309 Continued on the next page DuPont-5386 964 Company Sanitized. Does notcontain TSCA CBI H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations____________________________________________________ DuPont-5386 INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643309 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology : LIVER : HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. FATTY CHANGE, CENTRILOBULAR, minimal. NECROSIS, FOCAL, mild. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. HYPERTROPHY, TUBULAR, mild. LUNGS : INFLAMMATION, SUBACUTE/CHRONIC, minimal. THYMUS : ATROPHY, mild. THYROID GLAND : ALTERATION, COLLOID, moderate. HYPERTROPHY, FOLLICULAR, minimal. PARATHYROID GLANDS : NOT PRESENT. 643309 Continued on the next page .... 965 Company Sanitized*Do8 H90--2D45ay16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643309 Continued from previous page Histopathology : ESOPHAGUS : INFLAMMATION, SUBACUTE/CHRONIC, mild. EDEMA, mild. PHARYNX/LARYNX : HEMORRHAGE, mild. EYE(S) WITH OPTIC NERVE : OPTIC NERVE NOT PRESENT. BONE MARROW : HYPERPLASIA, GRANULOCYTIC, mild. NOSE : De g e n e r a t i o n , a m e l o b l a s t s , mild. INFLAMMATION, SUBACUTE/CHRONIC, mild. HYPERPLASIA/HYPERTROPHY, t r a n s i t i o n a l c e l l , e p i t h e l i u m , mild. MANDIBLE : NOT PRESENT. No Microscopic Abnormality Observed : HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, TRACHEA, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM 966 DuPont-5386 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxiactistywith One-Gnration Reproduction Evaluations_____________________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopie & Macroscopie Findings 643315 Terminal Sacrifice Killed on Day : 91 Exposure Group : 90-DAY EXPOSURE Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, ' PHARYNX/LARYNX, E Y E (S ) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, minimal. KIDNEYS : HYPERTROPHY, TUBULAR, mild. HEART : CARDIOMYOPATHY, minimal. THYROID GLAND : ALTERATION, COLLOID, mild. HYPERTROPHY, FOLLICULAR, mild. PROSTATE : INFLAMMATION, SUBACUTE/CHRONIC, moderate. 643315 Continued on the next page .... 967 Company Sanl DuPont-5386 H90--2D4a5y16G: aSvaugbechSrtoundiyc iTnoRxaictistywith One-Generation Reproduction Evaluations INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643315 Continued from previous page Histopathology : NOSE : DEGENERATION, AMELOBLASTS, mild. HYPERPLASIA/HYPERTROPHY, TRANSITIONAL CELL, EPITHELIUM, minimal. MANDIBLE : DEGENERATION, AMELOBLASTS, minimal. 643316 No Microscopic Abnormality Observed : LUNGS, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, SEMINAL VESICLES; URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, BONE MARROW Terminal Sacrifice Killed on Day : 125 Exposure Group : ONE-MONTH RECOVERY Animal is signed off from necropsy Gross Pathology : No Macroscopic Abnormality Observed : LIVER, KIDNEYS, LUNGS, HEART, SKELETAL MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CORD, STOMACH, DUODENUM, JEJUNUM, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC LYMPH NODE, SALIVARY GLANDS, MANDIBULAR LYMPH NODE, THYMUS, ADRENAL GLANDS, SCIATIC NERVE, PITUITARY GLAND, 643316 Continued on the next page .... 968 DuPont-5386 H-24516: Subchronic Toxicity 90-Day Gavage Study in Rats with One-Generation Reproduction Evaluations____________________ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS Dose Group : VII - 250 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 643316 Continued from previous page Gross Pathology : No Macroscopic Abnormality Observed : THYROID GLAND, PARATHYROID GLANDS, TRACHEA, ESOPHAGUS, PHARYNX/LARYNX, EYE(S) WITH OPTIC NERVE, SKIN, PROSTATE, SEMINAL VESICLES, URINARY BLADDER, TESTES, EPIDIDYMIDES, FEMUR/KNEE JOINT, STERNUM, NOSE, MANDIBLE Histopathology : LIVER : INFLAMMATION, SUBACUTE/CHRONIC, minimal. .HYPERTROPHY, HEPATOCYTE, CENTRILOBULAR, mild. FATTY CHANGE, MEDIAN CLEFT, minimal. NECROSIS, FOCAL, minimal. KIDNEYS : NEPHROPATHY, CHRONIC PROGRESSIVE, minimal. THYROID GLAND : ALTERATION, COLLOID, severe. NOSE : DEGENERATION, AMELOBLASTS, mild. No Microscopic Abnormality Observed : MANDIBLE DuPont-5386 969 Company Sanitized. Dow notcontain TSCA CBI