Document b5KajxYBvDxeQBgE74qDkV4xg

ce: . A. 3app, v'r. JUn* 9, 1975 .HacmrocM TOt TXMt S. M. XSCXK30, P1LMBT8 HOT. r.C. SK5SUBT ASD L P. IAS, HUQU LAJ3, CAa:JccggiciT? or unsay* rvxm 3sf.: Latter X. M. luclcriac to J-. A. Zapp, -t. 5-13-75. We vlll mtzmmpt to unu tba cjaaatlaoa you poaed la tba rafUraoea lattar la. tba ardaT pxeaanted. Tint, job eatod for oar Minin aa tba CJroaa at al. poblieatiaa co DscMted Hiaural Tiber* attached to yoor letter. It indieataa that tba lacaatioa by rata of a diet aa much aa 5% eabeetoe arar aoet at their Ufa did act prratica oaaear. 2sa, 1a addition to other ilxUsr experlaaBte reported la tba uhm artlala, ladleataa tlt lacaatad mineral fiber*, laaladin* aabaataa, do aot present tba baxard that baa baaa aaaodatad with tba inhalation of saee aiaural fibera. Aa Alt aa a know, tbara la no ln*le report tailaa tin* tuaor daitlrry--it la tba *aatroiataatinel tract raeultin* ftto feedin* aabaatea daat to axparlaaatal aalmla. Srpliaa to tba four additional, qaaatiena 70a raiaad ara m fallowst 1. St a natlaarlda ready of 2066 aea-d^ratta aaofcim aabaataa worker*, 73 daatba occurred but only tao vara daa to lane oaaear (^=nond ad MUfeoff 1975). Cba of tba tare mb waa a a*ar aad pipe Motor, aad tba ether bad aestar ranted rKuljerly. Tram, tbia obearmtlan, cm oaa rtata that 2aa( owner la uBeoasaa sarr< aabaatea aortas* aba bars no blatery af- dLauratte --nblnc aad that if tbara la a rlab laroltad, it la aot eraat. 2. As Initial atody of 205 aabaataa inaulatiai rarter* who bad a Matory of reculsr dtaretto "nnf rroalad that 2b bad dlad of 10x4 eanoar (BalUwff at al. 1968). Sowrrwr, dm tbair raratina babita, only 2.98 cash daatba would bar* baaa expected is tba control ^"t populatlai. tJalsc tbaaa flcurae tbara la about aa eishtfbld lneswuee la-Ian* nanner daatba la aabaataa wotaar* who nan to ci^xrtta* railarly nma ocn-aabaataa wortara who ara raxuler al^ratta Motors. )<^21 3UP 0903572 PLAINTIFFS I EXHIBIT DUP-158 9. M. Incrring - 2_ - 'uae 9, lq75 3. Of deaths that occurred aarag 532 nMftai sorters exposed to - ubattot dait 20 7Mrt or longer, 29 *" due to ^strointartiaal cancer, vftlla' 9.i would bare been expected la the control population (Beilinff at al. 19&.). Altbough tie data suggest that as seatos dust exposure increasad tba isddasoa of sastrolataatisal canear, tba naber of such daatba la too 11 to draw say definite ecueluaioa*. A recast surrey of daatba earwig 17,300 C.a. aad aabastoa insulation sextan sheared that l daatba vara due to tana.cn cancer Tarsua 6.62 expected deatha fraa tba control population; 26 obaarrad Tarsus 17.51 expactad deaths froa nuicar of tba colm>raetua; aad 13 obaarrad versus 3.51 expected, deaths from cancer of tba esophagus (Ihanmd aad Sellteff, 1573) Because of tba snail mother of expected and obaarrad daatba ftoai cancer at thasa sites among vortars vltb so bistory of dmratrta snaking, no eon- elusira itstenant can be aada that indicates a possible interaction between cigarette end asbestos exposure as tbay sight relate to gaatro- intastlnal cancers. However, other turreye indicate a high degree of asaaeiatica between cigarette niHwg and tba oceaxranea of cancar of tba eaophagns. lb spita of tba apparent relationship between exposure to asbestos dust and gastrointestinal cancer, the uniformly negative anlaal feeding etudes cast sons doubt on such a relationship. b. Of 9b deaths obaarrad among 370 aabastoa sorters, tee vara due to aasetbeliam, three vara pleural aasothellaans aad saves peritoneal (Selitoff at jil. 1968). Bis tumor la such a rare type that if tbs 770 subjects had been selected readonly Boa the general population, one would not expact any of than to dia of aseothalicaa. Pleural aad peritoneal assethall, rasa are fait to behavw differently la that the peritoneal type have Halted or no astaetasaa (TTvreon, 1969). aseerrar, glenraj seeor be Vt rail bare a range or ellpencr where rpreed by blood and lyapb can occur. Mora aigsifiaaat is tba direct spread to tba lung, liver, rertabral bodies, aezoae sag, parieaidian and otbar plea ml sacs. va hope this information vill be balpfal to yea aad if 70U wish to dispass any of tba shore points, plaaaa give oa a call. L. Bemad# I. C. aad X. J. Bali toff: Pv reading of a Mortise Cnaftesnee bald at tba International Agency far Btsaarcb m Cancer, Lyea, nenoa. IAK Selaatllle PuhlloatioB wo. 3., pp-512 (1973). 2. SalilDff, X. J., I. C. awm and J. Qnrg: JUA JObil06 (1968). 3- SeUboff, X. J., J. Cburg and I. C. Baralt <ZDA lg2a (19^). b. Boaaaa, J. 9.; PsecaoocnloaiJ. yrmaaUng of tba Btaastlanal Conference, Johannesburg, 150 (1969). CTBtDLilja DUP 0903573 I tBfgga"11""' T'^wfTrairiiriaraBK"^ ^ugaam-B' 'jiatj-jiMtejignw