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VISIT OF THE MANUFACTURING CHEMISTS ASSOCIATION PRESENTATIONS - JUNE 14, 1978 C'or'Y Chemical carcinogenesis multidisciplinary research group: Overview p. 1-5 2e Analysis and synthesis of chemicals and their use in bioassays for the identification of carcinogenic potential: o 1 A. Chemical systems of detection of vinyl monomer toxicity p. 6-12 3.z B. Reactivity of chemicals and their metabolites in various bacterial assays p. 13-17 ^ o Use of biochemical enzymatic systems for detection of chemical toxicity : -r< A. The characterization of biochemical enzymatic changes occurring with prolonged vinyl chloride exposure in animal and man p. 18-24 B. Vin}Tl chloride oxidation and detoxification p. 25-34 Carlo H. Tamburro, M.D. Professor of Medicine John Wong, Ph.D. Professor of Chemistry Uldis N. Streips, Ph.D. Associate Professor Microbiology and Immunology C.H. Tamburro, M.'D. Julie T. Du, Ph.D. Research Associate _6 Immunological and histopathological studies in chemical injury ; Si A. Immunopathology of vinyl chloride- induced liver angiosarcoma and effects on antigen antibodies p. 35-37 S' i. B. Search for evidence of vinyl chloride induced tumor antigen p. 38-41 S3 C. HLA frequencies in vinyl chloride workers p. 42-45 D. Evaluation of immunocompetence of humans chronically exposed to vinyl chloride p. 46-50 5.$ E. Tissue and urinary glycosaminoglycans in hepatic fibrosis and hepatic cancer p. 51-58 Enrique Espinosa, M.D. Professor of Pathology C.H. Tamburro, M.D. H.P. Fortwengler, M.S. Research Associate Charles E. Kupchella, Ph.D. Associate Director Cancer Center CMA 002782 %Hepatic cell identification technique p. 59-61 5.7 Medical surveillance system for industrial environments p- 62-89 5# Bioassay of chemical monomers in isolated mammalian liver cells p. 90-93 Summary overview p. 94-108 H.P. Fortwengler, M.S. Carlo H. Tainburro, M.D. Carlo H. Tamburro, M.D. Richard C. Feldhoff, Ph.D. Assistant Professor of Biochemistry Carlo H. Tamburro, M.D. Professor of Medicine MCA Project Director CMA,, 002783