Document b1GKpbOZyoXb7L3awyyzyZY1

Submitted to: BIOSEARCH, INC. p.o.box 8598 philadelphiap,ennsylvania19101 t e Ie p h o n e f2 1 5 846-4499 Project Number: 78-1161A 3M Company 3M Center St. Paul, Minnesota 55101 material: 3M Company - T-2038COC Sample Received: Date of Report: Test: Object of Test: Procedure: Results: Conclusion: 1/5/78 Study Initiated: 1/9/78 Study Completed: 1/23/78 2/2/78 Acute Oral Toxicity - Rats To study the acute oral toxicity in rats of the subject material. One group of 5 male and 5 female albino rats of the Sherman-Wistar Strain weighing between 200 and 300 gm were employed in this study. The rats were deprived of food but not water for 24 hours prior to dosing. Each animal was weighed and placed in an isolation cage with sufficient ground experimental material mixed with oatmeal to achieve a 5.0 gm portion of experimental material. The rats were allowed to eat the mixture during the next 24 hours. All of the mixture was consumed in all cases. The cage bottoms were examined to be certain all experimental material had been eaten. Following administration the animals were allowed food and water ad libitum for the 14 day observation period during which time the rats were observed for signs of toxicity and mortalities. See Table 1. The subject material when studied in male and female albino rats has an acute oral LD50 of greater than 5.0 gm/kg. z iz,@ eL"-t Karl L. Gabriel,V.M.D.,Ph.D. Director TABLE I Acute Oral Toxicity Material: 3M Company T-2038COC, as directed. Dosage Level gm/kg 5.0 5.0 Number of Animals Dosed 5 males 5 females Mortalities Days 1 2 3 4 5 6 7 8 9 10 11 12 13 14 0 0oIooo o 0 0 0 0 0 0 0 0 ooooo 0 0 0 0 0 0 0 The LD50 is greater than 5.0 gm/kg. There were no unusual behavioral signs noted. Gross pathologic examination revealed nothing remarkable. Total Dead ]A Days 1 0 Total Survi 14-Da 4 5