Document aZV650ZGep2dLqqEO0zbMN29

URL 15965 CHEMICAL MA April 1, 1980 APR? 1980 fl*rrMryi| DErt 'n\ l To: Subjects: Vinyl Chloride Project Panel I . Additional Histopathologic Examination of Brains from the IBT/vc Study II. Validation of Exposure Chamber Concentrations During IBT/VC Study by Means of G. C. Strip Chart Examinations. Gentlemen: As a result of Panel action on March 18, 1980, (please refer to page 2, item 3.0 of the Record of Meeting), Dr. William Busey will per form additional histopathologic examinations of brains from the IBT/VC study. Dr. Busey's work will involve: Five trained histology personnel on his staff On-location tissue accountability, search and retrieval at IBT facilities at Northbrook, Illinois. All material requiring histologic preparation (wet tissues and/or paraffin blocks) will be processed in Dr. Busey's laboratories. Experimental Pathology Laboratories, Inc. (EPL), Herndon, Virginia, onto microscopic slides. At least three sections will be processed from each brain retrieved from IBT/Northbrook. A detailed reading of each slide will be performed by Dr. Busey, and a final report will be prepared by Dr. Busey detailing his findings. .: EPL charges for the work described above will be $16,460. Pursuit of the validation of chamber concentrations during the last six months of exposure will involve random studies of at least 10% of all G. C. strip charts. The Audit Task Group advises CMA that third Formerly Manufacturing Chemists Association--Serving the Chemical Industry Since 1872. 1825 Connecticut Avenue, NW Washington. DC 20009 Telephone 202/328-4200 - Telex 89617 (CMA WSH)