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FILE NAME Talc TALC DATE 1972 Apr 25 DOC TALC065 DOCUMENT DESCRIPTION Letter to FDA from Barry Castleman VII April 25 1972 Gou M.rGodury dy M.D. Assistant Director for Medical Affairs Division of Colors & Commatics Technology Office of Product Technology - DepartofmHeeanltth Educaat nd i Welofan re Food and Drug Administration WashingtDo.Cn. 20204 for my to coPnucresrunanatbout yourprleestetenrt owfidAepsrpirelad19aIvwailil lofafebtroianalneiuxnptvlaayrnyation public of asbestos containpriodnucgts - Asbestos is a generic term applied to a group of hydrated silicata silicata minerals that separate readily into fibers They fall into two groups Herpentine crecidolit amoesite anthrophylite tremolite and satinelite About 95 of the world output is chrysotile Mortality studies of asbestos workers in mining processing and application of insulation materials have established that sccupational exposure to each of the mujer types of asbestos is associated with very high incidence of certain forms of cancer and asbestosis threshold only level these exposure are occupationally exposed asbestosis and the a strong cocarcinogenic rish mesothelioma affect was found among cigarette population in 0.01 to 0.1 of all deaths in a Lastly gastrointestinal cancer has relatively frequent occurrence mong sebestos workers and their familien and neighbors of asbestos plants and mines been found to occur in three to fourfold excess among some groups of asbestos workers studied Among the insulation workers studied by Solikoff 40 of these dead by 1971 died of the above causes in excess of the mortality experience which would be expected in this group based on specific U.S. death rates mortality experience is a measure of conditions effects of today's preventive manures will not biviensivbilesi1b9l4e0'usntailntdhe and of large quantity mesotheliom processing families sebeston workers The existing literature is able to provide us with curve for exposure of human populations to asbestos The safe laval response so low that it hasn't the been identifieodof formesmesoothetliomhesleiroiomuselyngueasssebdeassbesttos oAsnd woworrkkeresrs ailnarsmhinigpayreardsusaaereus reports of is and neighbors of asbestos mines processing plante aanndd By 1965 it was well established that cuberton especially asbestos inculating materials vere very basardous Tat sprayed asbestos fireproofing insulation was used from 1958 til 1971 in the metruction industry before Chicago and Boston boname the first cities to ban its use This materiails no pperrokbaarbalyccaarparntpareantawrheereMeMectcriciants rMectiricicansicaonusntreytct.odwaoyrkebduti3n,0t0h0e,s0e0s0trbuucitludriensg etvreardyesyear and there is every reason to expect a resulting epidemic of asbestos cancer mong these workers starting in the 1990's Stuilarly hanerde exist in sono consumer products where asbestos could be deleted or replaced with substitute materials Exspla six pordare for making puppets and manka in schools champ eigars as a binder to augment cohesiveness of the ash , imported women's costs y 19o 71ufrros m e Itl ahlmf ymm8baiclherrysionstuillaetifoinltenrusmawraodm to prepare fonde and building products in drugs hardware sterow filler in highway construction and sprayed automobile undercoating For a more emaplats list I mfer you to Professor I.J. Salikeoff Mount Sinai School of Medicine 100th St. and 5th Avenua New York New Mount Ansobnesatolsisits iufsedonienetxhtoautseands of produictts and I'd a gibveepe dao y'sssataloas rpyroa tveorthy at each of these applications Oibsvhiaozuasrldyous should beforebefore tnaokting any setion Treselite one of the least emmes and least commercially useful forma New York have been found to experience axconnive ratus ooff lung cancer Kleinsf zae l l ARd GS DIV HRALZH 14 663 1967 ventilatore packaging are dusted with tale If so is this mecousery or could a less suspect material corn starch for example be med instead I understand that contraceptive diaphragma are also tale dusted by usnufacturers Several papers have appeared suggesting literature literature a cause cervical ovarian cancer I ayidantolgy in the process reviewing a . literature on cervical ayidantology would contraceptives controls who process known performing or even publishing such a study now The prowib thlthe is ime there is good reason to suspect it is a carcinogen but the subject has received very little attention in the past In the dim light of our present imowledge unnecessary applications of this suspected careinegen en tissues which are prime mer sites abould | come undar federal scrutiny and regulation Enclosed are Criteria for a kecommended Standard .. Occupational Exposure to Asbestos by the U.S. Public Health Service a recent paper en dfsense basards associated with community asbestes air pollution by Selikoff dfsense Insulation 1912-1971 Korkers and by Selikoff . Mortality Experience Asbestos Insulation Korkers 1912-1971 I hope these references provide a more complete picture of the asbestos problem and answer some questions which my latter may have raised Inaddition I hope you will write or call 301-494-3i7f 7yo5u or your workers have questions which I might be able to help find the savers to There is a great deal more in the literature then I have been able to cover here I would be glad to spend an afternoon with you either hare or in Washington discussing the problems of nebestes and tale BC tank.