Document aJpzOd6ba4pVnjV6Jqy7r2pQX

3M General Offices 3M Center St.Paul,N4N 55144-1000 651 733 1110 August 31, 2000 VIA OVERNIGHT DELIVERY Dr. Charles Auer Director Chemical ControlDivision OfficeOf PollutionPreventionAnd Toxics United States EnvironmentalProtectionAgency 401 M Street,Southwest Room 403 East Tower (MailCode 7405) Washington, D. C. 20460 Re: Information On Perfluorooctane Sulfonates And Related Compounds Dear Charlie: Pursuant toour recentcommunications,3M isenclosingadditional informationon perfluorooctanesulfonatesand relatedcompounds. The enclosed informationsupplements informationsubmittedto you previouslyi,ncludingour letterdsated April21, May 4, May 18,May 25, and June 28, 2000. Again, we are providingthisinformationon a voluntarybasisas partofour continuing discussionswithEPA regardingfluorochemistry. We are enclosinginformationon perfluorooctanesulfonatesand related compounds thateitherpost-datesour most recentsubmission or has been locatedas partof our continuingfilseearch.The enclosed informationincludes: Copies of post-1976 studiesand certainotherinformationrelatintgo the followinghealtheffectasreas: (i)acutetoxicit(yi;ig)enotoxicity(;iirie)peateddose toxicit(yi;v)pharmacokinetics(;v)teratologya;nd (vi)medical surveillancaend epidemiology.We have organizedthisinformationinlabeled filefoldersforeach compound, and provideda detailedindex,toaid EPA's review. Some acute studiesare enclosed,whilelesssignificanatcute studies appear onlyas bibliographiecntrieson the index. The index also notes a few minor correctiontso earlieirndices. Copies of post-1976 studiesand certainotherinformationrelatintgo the followingenvironmentalscienceareas: (i)environmentalfateand transport and (iie)nvironmentalmonitoring.These materialsare containedina separatefilfeolderwithan index intableform. One enclosed environmentaldocument containsinformationthatqualifieass confidentiablusinessinformation(CBI);we have enclosed a sanitizedversionof thatdocument, and are submittingthe unredactedversionina sealed envelope. As inour priorsubmissions,many ofthe studiesreferto thetest substance onlyby a 3M productidentificatinounmber witha "T","L"or "FC" prefix.Althoughanalysisofthe testsubstance has been includedwhere availablei,tisoftennot possibletodeterminefrom the study reportitseltfhe identitoyfthe testsubstance. Thus, we have 3M's historicarlecordskeyed tothe 3M productnumber to determinethe compositionofthe testsubstance. Where availablet,he index providescompositioninformationsuch as percent composition,solventcontext,saltform and puritygrade forcompounds not so describedinpriorsubmissions. Please note thatthe term "narrowrange" refers to a higherpuritygrade of a compound. Finallyi,tshouldbe recognizedthat productformulationshave evolvedover the years;compositioninformationmay not be contemporaneous withthe toxicologystudies,and some of the test substances do not constitutceurrentproducts. 3M iscontinuingitsfilereviewand willsupplement the enclosed informationas appropriate.3M looksforwardtodiscussingthe enclosed informationwithyou and otherEPA staff.Inthe meantime, please do not hesitateto contactme withany questions. Very trulyyours Enclosures WilliamA. Weppner, Ph.D DirectorofEnvironmental,Health, SafetyAnd RegulatoryAffairs SpecialtyMaterialsMarkets 3M Bldg 236-lB-10 3M Center St.Paul,MN 55144 (651)733-6374 (phone) (651)733-1958 (fax) E-mail:waweppnerpmmm.com ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION TOXICOLOGY AND MEDICAL SURVEILLANCE PFOS -Tperfluorooctanesulfonate MedicaSlurveillaanncdeEpidemiologic I . InterimReport#1,Determinationof Serum Half-LivesofSeveralFluorochemicals, June 8,2000 (previouslsvubmittedtoTSCA 8(e)docket,iitcludehderefor cotivenietice) 2. Data regardinggeneralpopulationblood samples from severalcountriesanalyzedby ')M's EnvironmentalLaboratoryin 1999 (noreportwas prepared). Acute Toxic The followingpre-1976 studywas listeidnthebibliographoyf acutestudieswith a pn*or submission,but a copy isnow beingsubmittedforEPA's convenience: 1. Reportby WARF InstitutIen,c.and accompanying documentation,Pn*marySkin Irritatiaonnd Pn*maryEye IrritatiionnAlbinoRabbits,Sample T-1117 (FC-95), November 7, 1974 Acute Toxicity(Biblio,@,),Ornalpvhy- Copy Not Submitted) 1. FinalReport,AcuteOcularIrritatiToenstwithT-2997CoC inAlbinoRabbits,Safety EvaluationLaboratory,RikerLaboratoriesI,nc.,StudyNo. 0882EB0009, 3M ReferenceNo. T-2997 (perfluoroethylcylclohexylsulfDoEnAatesalt)J,anuary25, 1982. Genotoxicit I. FinalReport,revisedI,nVitroMicrobiologicaMlutagenicityAssays of 3M Company Compound T-2816CoC, SRI InternationaSlR,I StudyNo. LSC-8958, 3M Reference No. T-2816CoC (PFOS DEA salt)M,arch 1980. 2. FinalReport,InVitroMicrobiologicaMlutagenicityAssaysof -')MCompany's Compound T-2997 CoC (perfluoroethylcylclohexylsulfDoEnAatesalt)S,RI InternationaSlR,I Study No. LSC-8958, January198 1. Teratolog CorrectiontoMay 25 Index:Materialsprovidedwere incorrectliyndexedasLetterfrom E.MarshallJohnsontoWilliamC. McCon-nick. IndexshouldreadLetterfrom E. MarshallJohnson toDr. FranklinD. Gn*ffithr,egardingRikerteratologystudieson PFOS and ethylFOSE, November 12, 1982. ATTACHMENT TO LETTER TO C. AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION Repeat Dose 1. AdditionalData on 26-Week CapsuleToxicityStudywith PerfluorooctanSeulfonic Acid PotassiumSalt(PFOS, 3M ReferenceT-6295): a) DraftPathologyReport(AncillarSytudy),ElectronMicroscopicEvaluationof LiverinCynomolg,,uMsonkeys (RecoveryAnimals),StudyNo. 6329-223, PathologyAssociatesInternationaPlA,I Study Number EM 99.76,May 30,2000. b) Data on TSH and LipidsinCynomolgus Monkeys, AnilyticsIncorporated, reportedMay 2,2000,withaccompanying correspondenceincludinglettefrrom Andrew Seacat,Ph.D.to PeterJ.Thomford, Ph.D. datedMarch 6,2000, and letter from SaroiR. Das,Ph.D. toAndrew Seacat,Ph.D.datedApril5,2000 regarding methodology Phannacokl'netic I. The followingstudywas previouslyidentifieidnthelisotfpublishedliteraturae; copy now beingsubmittedforconvenience: An InvestigationftheEffectsofFluorocarbonson LiverFattyAcid-Binding Protein,thesissubmittedtotheGraduate Schoolof theUniversityof Minnesota,by Deanna J.Nabbefeld,April1998. Legend: FC I FC2 FC3 FC4 perfluorooctanesulfonicacid animonium perfluorooctanoate N-Ethyl FOSE N-ethylperfluorooctanseulfonamide 2. Final Report, 28 Day Percutaneous Absorption Study with FC-98 in Albino Rabbits, Safety Evaluation Laboratory, Riker Laboratories,Inc.,3M Reference No. T-4980, (perfluoroethylcylclohexylsulfonateE)x,periment No. 0979ABO630, March 15, 1981. 3. Final Report, Single-Dose Intravenous Phan-nacokinctic Study of T-6684 in Rabbits, Coming Hazleton, Study No. CHW 6329-199, 3M Reference No. T-6684 (didecyldlmethyl ammonium saltof PFOS), December 31, 1997. 4. Final Report, 5-Daily Dose Den-nal Absorption/Toxi cityPharmacokinctic Study of T6684 in Rabbits, Covance Laboratory, Study No. 6329-200, 3M Reference No. T6684 (didecyldimethyl ammonium saltof PFOS), December 31, 1997. [Draftof this reportwas submitted to EPA with letterdated May 18, 2000.] 2 ATTACHMENT TO LETTER TO C. AUER DATED AUGUST SUPPLEMENTAL SUBMISSION 31,2000 PFOS Mixtures Acute Toxicity(BibliogrqphOynly) I . FinalReport, Primary Eye IrritatioSntudy in Rabbits,Hazelton Laboratories America, Inc.,3M Reference No. T-4016, January 28, 1987. 2. FinalReport,Acute Oral ToxicityStudy in Rats,Hazelton LaboratoriesAmerica, Inc.,3M Reference No. T-4016, February 9, 1987. 3. Final Report, Primary Dermal lm'tatioSntudy in Rabbits, Hazelton Laboratories America, Inc.,3M Reference No. T-4016, February 27, 1987. POSF Perfluorooctanesulfonyl fluoride On,going Studie 1. Study Outlinedated June 22, 2000 and Protocoldated December 30, 1998 for Phannacokinetic Study of POSF in Rats,3M Reference No. T-7098. I. N-ETFOSE alcoh( lylperfluorooetane sulfonamidoethanol Acute Toxicit 1. FinalReport,Acute Oral Toxicity(LD50) Study inRats,FM-3422, International Research and Development Corporation,3M Reference No. T-2253, Study No. 137084, June 7, 1978 Phannacokinetic 1. Blotransfon-natioonf 14C-N-Ethyl FOSE in Rats AfterAdministrationin Feed for One Week, Riker Laboratories,Inc.,January 28, 1983. The copy of the following item issubmitted under PFOS: An Investigationof the Effectsof Fluorocarbons on Liver FattyAcid-Binding Protein,thesissubmitted to the Graduate School of theUniversityof Minnesota, by Deanna J.Nabbefeld, April 1998. 3 ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION TeratoLogy 1. Teratology Studieson FM 3422, 3M Reference T-3352: a) FinalReport,PilotRat Teratology Study, T-3352, Hazleton Laboratories America, Inc.,ProjectNo. 154-159, May 11, 1983. b) FinalReport,Rat Teratology Study,T-3352, Hazleton LaboratoriesAmerica, Inc., ProjectNo. 154-16 1,March 21, 1984. c) Protocol,Rat Teratology Study (Segment 11),T-3352, Hazleton Laboratories America, Inc.,June 2, 1983. CorrectionTo May 25 Index: Materialsprovided were incorrectlyindexed as Letter from E. Marshall Johnson to William C. McCormick. Index should read Letterfrom E. Marshall Johnson to Dr. FranklinD. Griffithr,egardingRiker teratologystudieson PFOS and ethylFOSE, November 12, 1982 Ongoin Note: Mechanisticresearchonn-ethyl FOSE, 3M Reference Nos. T-3616.10, FM 3923, isongoing atthe Universityof Minnesota under the directionof Kendall Wallace. Documents regardingthisresearchwere submitted with the May 4, 2000 submission on PFOS (seeMechanistic 1)(a)-(f)b)ut were not indexed under N-ethyl FOSE. N-Etl @i-ethylpernuorooctanesulfonamide Acute Toxicit 1. FinalReport,Acute Oral ToxicityScreen with T-3067CoC in Albino Rats,Safety EvaluationLaboratory,Riker Laboratories,Inc.,Experiment No. 0981AR0147, 3M Reference No. T-3067 (narrow range ethylFOSA), May 15, 1987. Correctionto May 18 Submission: Three studiesconducted by Coming Hazelton (CHW 61101149, CHW 61101150, and CHW 6110115 1) were erroneously listedon theMay 18,2000 bibliographyunder N-ETFOSA (Acute Toxicitybibliographyonly items I - 3). These studiesshould not have been listedthere.They did correctlyappear on theMay 18 bibliographyunder PFOS and were provided under PFOS Acute ToxicityI(a)-(c). 4 ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION Phannacokinetic 1. FinalReport, Single-Dose IntravenousPharmacokinetic Study of T-5904 in Rabbits, Hazleton Wisconsin, 3M Reference No. T-5904 (95-99%), Study No. HWI 6329-117, October 14, 1994. Submitted above under PFOS: An Investigationof the Effectsof Fluorocarbons on Liver FattyAcid-Binding Protein,thesissubmitted to the Graduate School of the Universityof Minnesota, by Deanna J.Nabbefeld, April 1998. Ongoing Mechanistic researchatthe Universityof Minnesota under the directionof Kendall Wallace includesN-Et FOSA, 3M Reference No. T-6868. 1. Documents regardin1-c@ t,his research have been previously submitted with the May 4, 2000 submission on PFOS (see Mechanistic 1)(a)-(f)). PFHS Perfluorohexane sulfonate .Medical Surveillance and Epidemiologic See item I under PFOS: InterimReport #1, Determination of Serum Half-Livesof Several Fluorochemicals,June 8,2000. FOSAorPFOSA orooctanesulfonamide Medical Surveillanceand Epidemiologic See item I under PFOS: InterimReport #1, Determination of Serum Half-Livesof SeveralFluorochemicals,June 8, 2000. Ongoing - Pharrnacokinetic I . ProtocolforStudy No. T-7132.2; ST-39, Phannacokinetic Study of Perfluorooctane Sulfonamide in Rats,3M Medical Department, Corporate Toxicology Laboratory, In-LifeEnd Date November 2, 1999, reporton in-lifsetudy pending. We are providinga copy of the Laboratory Report,AnalyticalReport of Data forPFOSA Phan-nacokincticStudy in Rats (Sera and Liver),3M Environmental Laboratory, Laboratory Report No. FACT-TOX- 145 (W2814), 3M Reference No. T-7132.2, December 6, 1999. 5 ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION PFOSAA Perfluorooctanesulfonylamido(ethyl)acetate MedicalSurveillancaend Epidemiologic See item I under PFOS: InterimReport #1, Determination of Serum Half-Livesof SeveralFluorochemicals,June 8, 2000. Acute Toxicity(BibliographyOnly) I. FinalReport,Acute Oral ToxicityStudy in Rats,Hazleton LaboratoriesAmerica, Inc.,Study No. 70905392, 3M Reference No. T-4101, FC-109 (19-23% PFOSAA Potassium saltin water),January 21, 1988. 2. FinalReport,Acute Dermal ToxicityStudy inRabbits (OECD Guidelines),Hazleton Laboraton*esAmerica, Inc.,Study No. 70905393, 3M Reference No. T-4101, FC-109 (19-23% PFOSAA Potassium saltin water),January 18, 1988. 3. FinalReport, Pn*mary Derrnal lm*tation/CorrosionStudy in Rabbits,Hazleton LaboratoriesAmen'ca, Inc.,Study No. 70905394, 3M Reference No. T-4101, FC-109 (19-23% PFOSAA Potassium saltin water),January 18, 1988. 4. FinalReport,Primary Eye Irritation/CorrosiSotnudy in Rabbits,Hazleton Laboraton'esAmen'ca, Inc.,Study No. 70905395, 3M Reference No. T-4101, FC-109 (19-23% PFOSAA Potassium saltin water),January 18, 1988. Ongoin Mechanistic researchat theUniversityof Minnesota under thedirectionof Kendall Wallace includesPFOSAA, 3M Reference No. T-6896. 1. Documents regarding this researchhave been previouslysubmitted with theMay 4, 2000 submission on PFOS (see Mechanistic 1)(a)-(f)). PFOA Perfluorooetanoic acid Medical Surveillanceand Epidemiologic See item 1 under PFOS: Interim Report #1, Determination of Serum Half-Lives of Several Fluorochemicals,June 8, 2000. 6 ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION Acute Toxicit 1. Final Report, Acute Oral Toxicity Study in Rats, Hazleton LaboratoriesAmerica, Study No. HLA 91201739, 3M Reference No. T-4416 (approximately 45% FC-143 solid-sC7H I5COO-NH4+, 2.2% homologs, 50% water, 2.5% inerts),April 2, 1990. 2. Final Report, Primary Dermal lm*tation/CorrosionStudy in Rabbits (OECD Guidelines),Hazleton Laboratories America, Study No. HLA 91201740, 3M Reference No. T-4416, February 14, 1990. 3. Final Report, Primary Eye Irritation/CorrosioSntudy in Rabbits (OECD Guidelines), Hazleton LaboratoriesAmerica, Study No. HLA 91201740, 3M Reference No. T4416, February 28, 1990. Genotoxicit I. Final Report, Mutagenicity Test on T-6358 Measuring Chromosomal Aberrations in Chinese Hamster Ovary (CHO) Cells,Coming Hazelton Inc.,Study No. 17388-0437, 3M Reference No. T-6358, FC-143, Lot 33-@)A,pril 25, 1996, with protocol. 2. Final Report, Mutagenicity Test on T-6358 in an In Vivo Mouse Micronucleus Assay, Coming Hazleton Inc.,Study No. 17388-0-455, 3M Reference No. T-6358, FC-143, Lot 332, May 14, 1996, with protocol and protocol amendments. Phan-nacokinetics Submitted above under PFOS: An Investigationof the Effectsof Fluorocarbons on Liver Fatty Acid-Binding Protein,thesissubmitted to the Graduate School of the University of Minnesota, by Deanna J.Nabbefeld, April 1998 Ongoin 1. Mechanistic research atthe University of Minnesota under the directionof Kendall Wallace includes PFOA, 3M Reference No. T-6889. 1. Documents regarding this research have been previously submitted with the May 4, 2000 submission on PFOS (see Mechanistic 1)(a)-(f)). ATTACHMENT TO LETTER TO C. AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION ENVIRONMENTAL Title FluorochemicalCharacteri@ationo@Surfa-ce Water Samples Columbus.GA (W2336) FluorochemicalCharacterizationf Surface Water Samples Cleveland,TN (W1973) -@luoroc-hemicaClharacterizationf Surface Water Samples Decatur,AL (W 1979) FluorochemicalCharacterizationf Surface Water Samples Mobile,AL (W215 1) FluorochemicalCharacterizationf Surface Water Samples PensacolaF,L (W2176) FluorochemicalCharacterizationf Surface Water Samples PortSt.Lucie,FL (W2363) FluorochemicalCharacterizatiofn Surface Water Samples PortSt.Lucie,FL (W2363) FinalMulti-CityStudy. FieldReportfor Mobile Alabama and PensacolaFloridaBattellDeuxbury Activities Laboratoryor Author Centr.A-nalytical LaboratoriesI,nc. CentreAnalytical LaboratoriesI,nc. CentreAnalytical LaboratoriesI,nc. CentreAnalytical LaboratoriesI,nc. CentreAnalytical LaboratoriesI,nc. CentreAnalytical LaboratoriesI,nc. CentreAnalytical LaboratoriesI,nc. BattellMeemorial Institute FinalMulti-CityStudy. FieldRepor-tfor ClevelandTennessee and DecaturAlabama BattellDeuxbury Activities BattellMeemorial Institute FinalMulti-CitSytudy.FieldRepoiiforColumbus Georgiaand PortSt.LucieFlorida - BattellDeuxbury Activities BattellMeemorial Institute PortSt.LucieFloridaWater and Sediment Resample fortheEmpiricalHuman Exposure Assessment Multi-CityStudy SulfonatedPerfluorochen-licaUl.sS:. Release Estimation- 1997 Part1:Life-CycleWaste Stream Estimates- ExecutiveSummary Pace Analytical Services,Inc. BattelleMemorial Institute Completion Date -@i241@00 5/24/00 5/24/00 5/24/00 5/24/00 5/24/00 August,2000 9/29/99 (Addendum signedon 10/13/99) 7/9/99 (Addendum signedon 12/6/99) 10//26/99 (Addendum signedon 12/6/99) 8/15/00 4/21/2000 Type FinalReport FinalRepor-t FinalReport FinalReport FinalReport Report FinalReport FinalReport FinalReport FinalReport Report FinalReport 8 ATTACHMENT TO LETTER TO C. AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION TOXICOLOGY AND MEDICAL SURVEILLANCE PFOS Perfluorooctanseulfonate Medical Surveillanceand Epidemiologic I . Interim Report #1, Determination of Serum June 8, 2000 (previous4, submitted to TSCA convenience) Half-Lives of Several Fluorochemicals, 8(e) docket, included herefor 2. Data regarding general population blood samples from several countriesanalyzed by 3M's Environmental Laboratory in 1999 (no reportwas prepared). Acute Toxicit The following pre-1976 study was listedin the bibliography of acute studieswith a prior submission, but a copy isnow being submitted for EPA's convenience: 1. Report by WARF InstituteI,nc.and accompanying documentation, Primary Skin Irritatioannd Primary Eye Irritatioinn Albino Rabbits, Sample T-1 117 (FC-95), November 7, 1974 Acute Toxicity (Bibliographv Only - Copy Not Submitted) 1. Final Report, Acute Ocular IrritatioTnest with T-2997CoC in Albino Rabbits, Safety Evaluation Laboratory, Riker Laboratories,Inc.,Study No. 0882EB0009, 3M Reference No. T-2997 (perfluoroethylcyiclohexylsulfonatDeEA salt),January 25, 1982. Genotoxicit I . Final Report, revised,In Vitro Microbiological Mutagenicity Assays of 3M Company Compound T-2816CoC, SRI International,SRI Study No. LSC-8958, 3M Reference No. T-2816CoC (PFOS DEA salt),March 1980. 2. FinalReport. In Vitro Microbiological Mutagenicity Assays of 3M Company's Compound T-2997 CoC (perfluoroethylcylclohexylsulfonatDeEA salt),SRI International,SRI Study No. LSC-895 8, January 198 1. Teratolpgy Correction to May 25 Index: Materials provided were incorrectlyindexed as Letterftom E. Marshall Johnson to William C. McCormick. Index should read Letterfrom E. Marshall Johnson to Dr. Franklin D. Gn'ffith,regarding Riker teratologystudieson PFOS and ethyl FOSE, November 12, 1982. ATTACHMENT TO LETTER TO C.AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION Repeat Dose 1. AdditionalData on 26-Week Capsule ToxicityStudy with PerfluorooctaneSulfonic Acid PotassiumSalt(PFOS, 3M ReferenceT-6295): a) DraftPathologyReport (AncillarSytudy),ElectronMicroscopicEvaluationof Liverin Cynomolgus Monkeys (Recovery Animals),Study No. 6329-223, PathologyAssociatesInternationaPlA,I Study Number EM 99.76,May 30, 2000. b) Data on TSH and Lipidsin Cynomolgus Monkeys, AnilyticsIncorporated, reportedMay 2, 2000, with accompanying correspondenceincludinglettefrrom Andrew Seacat,Ph.D. to PeterJ.Thomford, Ph.D. datedMarch 6,2000, and letter from SaroiR. Das, Ph.D. toAndrew Seacat,Ph.D. datedApril5,2000 regarding methodology Pharmacokinetic I. The followingstudywas previouslyidentifieidnthelistofpublishedliteraturae; copy now being submittedforconvenience: An Investigatioonf theEffectsof Fluorocarbonson LiverFattyAcid-Binding Protein,thesissubmittedtothe Graduate School of the Universityof Minnesota,by Deanna J.Nabbefeld,April 1998. Legend: FC I perfluorooctanseulfoniaccid FC2 ammonium perfluorooctanoate FC3 N-EthylFOSE FC4 N-ethylperfluorooctasnuelfonamide 2. FinalReport,28 Day PercutaneousAbsorptionStudy with FC-98 in Albino Rabbits, SafetyEvaluationLaboratory,Riker LaboratoriesI,nc.,3M Reference No. T-4980, (perfluoreothylcylclohexyslulfonate)E,xperiment No. 0979ABO630, March 15, 198 1. 3. FinalReport,Single-DoseIntravenousPharmacokineticStudy of T-6684 in Rabbits, Coming Hazleton,Study No. CHW 6329-199,3M ReferenceNo. T-6684 (didecyldimethyalmmonium saltof PFOS), December 31, 1997. 4. FinalReport,5-DallyDose Den-nalAbsorption/ToxicitPyhan-nacokinetiSctudy of T6684 inRabbits,Covance Laboratory,Study No. 6329-200, 3M ReferenceNo. T6684 (didecyldimethyalmmonium saltof PFOS), December 31, 1997.[Draftof this reportwas submittedtoEPA with lettedratedMay 18,2000.] 2 ATTACHMENT TO LETTER TO C. AUER DATED AUGUST 31,2000 SUPPLEMENTAL SUBMISSION PFOS Mwiixxttuurreess Acute Toxicity (Bibliography Only) I . FinalReport, Primary Eye IrritatioSntudy in Rabbits,Hazelton Laboratories Amen'ca, Inc.,3M Reference No. T-4016, January 28, 1987. 2. FinalReport, Acute Oral ToxicityStudy in Rats,Hazelton Laboraton'esAmerica, Inc.,3M Reference No. T-4016, February 9, 1987. 3. FinalReport, Primary Dermal lm*tationStudy in Rabbits,Hazelton Laboratories America, Inc.,3M Reference No. T-4016, February 27, 1987. 3