Document aJpKDMdBd57r7zZzZVpmzq0JX

L iEALTH aid |. Lick USA mond K. Locke A . Magee USA 'ard J. Mattaro A er O. McClellan SA ph McLaughlin >A tard McNamara iA js J. Menn USA id Menzei USA ert E. Memer SA i I. Munn USA I A. Pfltzer USA !$ Ram*! Sweden t Sinner Norway . Sidorenko USSR l. Sinclair* UK el Somberg USA i. Stoewiand USA mat R. Tephly SA edetto Terracini SA .. Thomas USA ryk Urbanowicz iland uld M. Valerino SA ics L. Wlttliff USA derick W. Wolff SA lerYeary USA - fee through the nc., 21 Congress * copying beyond 7 and 108 of the 1978 articles the *esponsibility for lion expressed in i advertisements. Environmental i by Hemisphere OGY ANO EN5SN 0098-4108) $67.50 per year $33.75 per year biishing Corpora* .W., Washington, age paid at Wash* mailing offices. :u changes to Y AND ENVIR* Vermont Awe., m, D.C 20005. si* i joumcF TOXIGOLOGYand ENVIRONMENTAL HEALTH CONTENTS Numbers 5-6 Sept./Nov. 1980 OCCUPATIONAL CANCER AND CARCINOGENESIS INTRODUCTION. H. Vainio, M. Sorsa, and K. Hemminki, Guest Editors 921 HISTORICAL PERSPECTIVES OF OCCUPATIONAL CANCER. P. Bogovski r Part One: Current Aspects of Cancer Etiology 941 IMPORTANCE OF ENVIRONMENTAL AND OCCUPATIONAL FACTORS IN CANCER John Higginson 953 LIFE-STYLE IN OCCUPATIONAL CANCER A. M. Adelstein 963 DIETARY COMPONENTS AND CANCER. Eino Hietanen 971 RADIATION CARCINOGENESIS, forma Rantanen y.|o A ii 977 SOMATIC MUTATION THEORY. Maria Sorsa Ci-O _ t 983 HEREDITY OF CANCER, fuhanl Rapoia Part Two: Carcinogenesis at the Molecular Level 989 METABOLIC ACTIVATION AND INACTIVATION OF CHEMICAL CARCINOGENS. O. i Peikonen and K. Vfhikangas 1001 ALKYLATION OF DNA AND CARCINOGENICITY OF N-NITROSO COMPOUNDS. Ruggero Montesano, Anthony E. Pegg, and Geoffrey P. Margison 1009 BINDING OF POLYCYCLIC AROMATIC HYDROCARBONS TO DNA: COMPARISON WITH MUTAGENESIS AND TUMORIGENESIS. Olavi Peikonen, Kirsi Vahakangas, and Danid W. Nebert 1021 ASBESTOS AND METALS AS CARCINOGENS. Tor Norseth 1029 1059 1065 Part Three: Detection of Chemical Cardnogms IDENTIFICATION AND DEFINITION OF CHEMICAL CARCINOGENS: REVIEW OF CRITERIA AND RESEARCH NEEDS. Umberto Safflotti DNA REPLICATION, REPAIR, AND REPAIR TESTS. Bo Lambert SHORT-TERM MUTAGENICITY TESTS. Claes Ramel and Ulf Rannug URL 05127 Contents {continued) URL 05128 1077 1081 CYTOGENETIC METHOD5 IN THE DETECTION OF CHEMICAL CARCINOGENS. Marja Sorsa NEW CONCEPTS OF DESIGN AND UTILITY OF LARGE-SCALE CARCINOGENICITY STUDIES. Lawrence Fishbein 1101 1109 1115 1127 Part Four: Epidamioiofic Approach** in Carcinogen Detection TOXICITY OF VINYL CHLORIDE AND POLYVINYL CHLORIDE AS SEEN THROUGH EPIDEMIOLOGIC OBSERVATIONS. Joseph K. Wagoner, Peter F. Infante, and Rosanne B. Apfeldorf CANCER REGISTRIES IN THE EVALUATION OF OCCUPATIONAL CANCER. L. Teppo TRANSPLACENTAL CARCINOGENS AND MUTAGENS: CHILDHOOD CANCER, MAL FORMATIONS, AND ABORTIONS AS RISK INDICATORS. K. Hemminki, I. Saloniemi, K. Luoma, T. Salonen, T. Partanen, H. Vainlo, and E. Hemminki ASPECTS OF CONFOUNDING AND EFFECT MODIFICATION IN THE ASSESSMENT OF OCCUPATIONAL CANCER RISK. OUv Axelson 1133 1179 1187 1195 1201 1211 1219 1229 1237 1245 1253 1261 1267 Part Five: Rlafc Branch** in industry POTENTIAL CARCINOGENIC AND MUTAGENIC INDUSTRIAL CHEMICALS. I ALKYLATING AGENTS. Lawrence Fishbein CHEMICAL HAZARDS IN THE PLASTICS INDUSTRY. H. Vainio, P. Pfaffli.and A. Zitting POLYCYCLIC AROMATIC HYDROCARBONS IN FOUNDRIES. Rainer W. Schimberg, Pirkko Pfjtffli, and Antti Tossavainen EPIDEMIOLOGY OF LUNG CANCER IN FOUNDRIES. S*ari Tola TOXICOLOGICAL ASPECTS OF CHEMICAL HAZARDS IN THE RUBBER INDUSTRY, Bo Holmberg and Blrgitta Sjtetrdm CANCER RISK AMONG RUBBER WORKERS. Matti Hakanuand lira Kilplkari CANCER HAZARDS CAUSED BY NICKEL AND CHROMIUM EXPOSURE. Tor Norseth ARSENIC COMPOUNDS AND CANCER. Olav Axelson SISTER CHROMATID EXCHANGE AND CHROMOSOME ABERRATIONS IN LYMPHO CYTES OF LABORATORY PERSONNEL. B. Lambert and A. Lindblad CHLORINATED HYDROCARBONS AND CANCER: EPIDEMIOLOGIC ASPECTS. Olav Axelson OCCUPATIONAL CANCER OF THE URINARY BLADDER. Sakari Tola ASBESTOS AND CANCER IN FINLAND. Matt) S. Huuskonen CANCER INCIDENCE AMONG PAINTERS AND SOME ALLIED TRADES. Anders Engfund 1275 Part Six: Rbfc AMMMrwnt OVERVIEW OF SOME ASPECTS OF QUANTITATIVE RISK ASSESSMENT. Lawrence Fishbein Contents (continued) RCINOGENS. Marja 1297 THE MORALS OF RISK ASSESSMENT. Ralph E. Yodaiken 1 1303 WORKER INVOLVEMENT IN RISK ASSESSMENT. Bo Holmberg CARCINOGENICITY 1 1309 THE PROBLEM OF EXTRAPOLATING FROM OBSERVED CARCINOGENIC EFFECTS TO ESTIMATES OF RISK FOR EXPOSED POPULATIONS. Umberto Saffiotti 1327 PANEL DISCUSSION: EXTRAPOLATION FROM ANIMAL EXPERIMENTS TO HUMANS. \5 SEEN THROUGH fante, and Rosanne B. 1i |1 Pavel Bogovski, Larry Fishbein, Bo Holmberg, Peter Infante, Ruggero Montesano, Claes Ramel, Umberto Saffiotti, and Marja Sorsa Following page 1335: CANCER. L. Teppo *OD CANCER, MALninki, 1. Saloniemi, K. i TITLE PAGE TO VOLUME 6 CONTENTS OF VOLUME 6 AUTHOR INDEX TO VOLUME 6 iE ASSESSMENT OF i SUBJECT INDEX TO VOLUME 6 \L CHEMICALS. 1. , Pfaffli, and A. Zitting Rainer W. Schimberg, i i ! 1 URL 05129 JBER INDUSTRY. Bo > Kilpikari URE. Tor Norseth ' i 1 VTIONS IN LYMPHOd )GIC ASPECTS. Olav ola iDES. Anders Englund SESSMENT. Lawrence i i i i i * I NOTICE Because this volume is appearing as an issue of the journal of Toxicology and Environ mental Health as well as a hardbound book, it was necessary to use a numbering system that would incorporate both the continuous journal page numbers and the book page numbers. The pages are double-numbered as follows: page 1 of the book is equivalent to page 921 of the journal. The numbers appear on the pages as journal page number followed by book page number in brackets. URL 05130