Document aJROOzLZnBovrOq8OzbBEm2kR

connlc: AV i VA-tAMCrON D. C 2C000 (2 02) 4 3 3 - G12 5 November 19, 1S71 Parcic Confer I * C G m November 16, 1971 Vinyl Chloride S'uDj 0 ( Report on Proceedings of the Conrerence Held C*. t. note. .shingron, 77e.3hin.gton, D, Aotiono.arce i Anthony, M. V. Bell, Z. G. Cassidy, L. E. Duffield, D. P. Fedoruk, J. Co Fritz, R,, J. ^tibbe t1, J. F . ^fendricks, N. V. Johnson, M. N. Johnson, K. D* Knapp, 'J. A. Knoepfel, R. W, 'Lefevre, M. J. Lindquist, A. 3. McCormick, W. E. Madden, W. VI. Mudd, J. R. Pitts, S. F. Siegel, A,, C. Sheth, K . K. Sm i th, VI. M. Torkeison, T. R. Weekers, Pierretv^uii-^ w.uV7hceler, R. N/ White, N. G. Zv'icker, B.M.G. Stauffer Chernies . Company PPG Industries, be . Canaciai Industries, Ltd. ICI Ltd. - Allied Chemical C GvtiO ciiiy Esso Chemical Company Pantasote Company of New York Standard Oil Company (N.J.) Monsanto Company Manufacturing Chemists Association Allied Chemical C&m-pa-ny c-q- Solvay American Solvay et Cie Stauffer Chemical Company The B. F. Goodrich Company Firestone Plastics General Tire & Rubber Company Continental Oil Company Tenneco Chemicals, Inc. Allied Chemical Com-p-a-nytfvy. Air Products and Chemicals, The Dow Chemical Company Solvay et Cie Inc. 0*rj Union Carbide Corporation. Shell Chemical Company The B. F. Goodrich Company AS I 000241 68 Our present awareness of the alleged carcinogenicity of vinyl chloride monomer has resulted from studies begun in an effort to elucidate the mechanisms of pathenogenesis of the acroosteolysis seer, in some vinyl chloride workers. As most of the companies rarerosented at this mooting were participants in, or otherwise c or.cornea j re dope:: adeq; nor o anas * O- J .. t1 l_ n r O ii a g j_ S i.., or O'; cc u :no university or . D. Johnson (MCA cc-rff representative) lea on h r hrlor report: tno soatus of no project. indicot ion of oh interest of the project spon- ns: on o thc program beyond the exhaustion of ds, and minted out than there is now on n . tne inaivinuai prop ecu sponsors, tor tne in a: of the Registry for several - S' `--1 / -i u o h*pon a showi nq of intersst by the delegates present, Dr. Johnson agreed to send copies to earn sponsor of the University of Michigan proposal for a project extension, together with a report: of his remaining credit and anticipated cost for the indicated contract extension. He extended to any companies, not now a project sponsor, that have employees at risk and that may wish to become a party to the study, an invitation to request more detailed information on programs and costs from him at MCA.. (Mote: subsequent to the Conference, MCA received a University of Michigan proposal estimating a cost of $4,000 per y; :or the maintenance of the Registry and it; ; records.) Mr . N. V. Hendricks S UTTumarized the recent events and publi cations via I. Cl; had alerted the incus tr y to the reported tumeroger ic prope.ru ies of vinyl chlor ide, and cal led upon Mr. McCormick to report: on tTl G studies of tin i s problem that had been made by MCA1 s Occupational Health Committee. Mr. McCormick reviewed the literature reports, and summarized the information that had been received from Dr. P. L. Viola, the principal investigator in the reported studies, during a visit to the U. S. by Dr. Viola under the sponsorship of a group of inter ested companies. On the basis of these data, a suggested research protocol has been developed, and cost estimates secured from a number cf competent consulting laboratories :or the performance of the specified tests. Dr. Marcel Lefevre traced the experience of Solvay et Cie with industrial hygiene problems associated with vinyl chloride synthesis and polymerization, and defined the relationship of his company to Dr. Viola's studies, both past and current. He revealed that additional exposure studies, at seven concentration levels, are now underway with a "composite" source of vinyl chlor ide, 50% acetylene derived and 50% from ethylene dichloride. It appeared that any U. S. research should seek answers to three questions: ASI 00024169 (1) Are the tumerogenic properties of the vinyl chloride used in his studies by Dr. Viola related to vinyl chloride, oer se, or to impurities present? (2) Ii impureticg are implicated, are the significant co: ta a: inants unequaly roiatod uo one or another of the commercial vinyl chloride synthesis methods? (3( Ii the pertinent carcinogen can be identified, can a "no-offectr/" level be demonstrated? T' mr.ucn as fne material usee oy Dr, Viola was of undocumented cot.nos r n:, and variously noted to contain from 1 to 3 percent im purities, and whereas American commercial practice now may specify total organic impurities to as low sm 100 ppm. (99.99% assay), some hope, but not great confidence, was expressed that it could be shown that Dr. Viola's results were attributable to the impurities in his sample,, X:. Knoepfei volunteered to attempt to identify the production lots from which Dr. Viola had secured his samples, and to secure available analytical data on such lots. The qualitative list of the impurities reported by Dr, Viola as present in his v .McCormick reviewed the test protocol his group had sugge; ted, and expressed his view that current plans should content the eventual need of an epidemiological survey of workers with pos sible exposure to potentially carcinogenic concentrations of atmospheric contaminants in vinyl chloride operations. He comrnentec thereby that the $183,000 low bid must be considered as just the start o r tne anticipated .protect costs, md that any epidemiology or protocol expansion could substantially increase the funding re- The suggestion that research costs be reduced by limiting the tests with acetylene-derived material to the highest exposure level only, primarily as a "positive control," received general support. The problems of defining routes of funding o: concurrence on a specific test protocol led to the decision to appoint a smaile: study group to reach agreement on these points and to report the results their deliberations in the :orm o: a specific research oropos. with specific funding requirements and mechanisms. One of the major questions posed to this group was the extent to which tests should be planned on a concurrent basis, to save time, or on a sequential basis, to minimize investment in tests subsequently shown to be unnecessary or non-informative. AS l 00024170 ir:c.i:.viau;. ir; v:erc- doc iciia Led to servo on tn:.s k J . S ' >, s , . Cj .S ,, .. O .< , ._ no:: '.v'nin management aotorr.inea ouiu ...eo: t oooxooriaiv ouera~s ns a v c-nonc g i o ._<,.;, v'ooooX- spec r r .Lc j, i.e*s any s t a nd a na M CA tec nrcct corvbv.oec. v;ith oversight on boha of MCA th r oug h j_ 0- S C* 4^- c. x. rji-'T'-^cr^azivv, Dr,, X. D. Johnson. V/he and if the Y Pr G S iJiJ u cl or ,MCA a dm.inis ti* a t i o n. an y su ch pro j c c t a u chov nos or organrzattonal supervision ana reporter.' : tierin' com it tec set uo to guide the oroj ecu. Ad Hoc Planning Grout tor Vinyl Chloride Research / Dr . I Vice Stauffer Chemical Company cuirc i20o ]. 6 11 R S c r e e t, X. V;. a s n m g e o n / r . * ZO O,-a /un jr-<o (202) 347-7627 ns sip 'Cant jitgc .or ^or Environmental Sciences Standard Oil Company (N.J.) Medical Department 30 Rockefeller Plaza New York, New York 10020 (212) 974-2786 X* N. Johnson, Mi. D. Assistant Medical Director Mon santo C omp any 800 X. Lindbergh Boulevard St. Louis, Missouri 63166 (314) 694-2183 Kenneth S. Lane, M. D. Assistant, Medical Director Union Carbide Corporation 270 Park Avenue New York, New York 10017 (212) 551-4787 Mr. V7. E. .McCormick Manager, Department of Environmenta 1 Control The 3. F. Goodrich Company 500 S, Main Street Akron, Ohio 44313 (216) 379-2562 Dr. T. R. Torkelsor. Toxicology Specialist The Dow Chemical Company Chemical Biology Research 1303 Building Midland, Michigan 48640 (517) 636--5197 YMr. Norman G. White cinager, industrial i'iygj_ene Shell Chemical Company Div. of Shell Oil Company 2525 Murworth Houston, Texas 77025 (713) 666-6311 i/Mr. Benjamin M. G. Zwicker Director, Technical Planning B. F. Goodrich Chemical Company A Div. of The B. F. Goodrich Co. 3135 Euclid Avenue Cleveland, Ohio 44115 (216) 881-8200 Dr. Kenneth D. Johnson Manufacturing Chemists Associati 1825 Connecticut Avenue, N. W. Washington, D. C. 20009 (202) 483-6126 x 244 ASI 00024171 -O' :O":0. acmou non 2- 4 and the Plan: t hould be solicited for air commercial grade of vinyl chloride listing identified ear fries and their characteristic ranees, methods of oiysis, and limits of detection; rv zo:I nearest be determined in contracting for the provis ion of a supply of vinyl chloride of uniform quality O V 0 r t c life of the research project, including their orooos d specifications and analytical verification of soecifreation conformance; 3) the Planning Group's proposal should include a recommen dation for funding on a sharing of costs prorated among Oct] ,ic roar: :g vinyl emo ide producers and polymerizers on tie basi ;otai canacitv nonomer synthesis plus w C production, each taken separately, as published in Oil, Paint and Drug Reporter and/or the Stanford Research Institute's Directory of Chemical Producers, is shown in attachment to this report); (4) that discussions with the offering laboratories be con tinued to clarify cost changes associated with suggested protocol modifications, and that Drs. Lane, M. N. Johnson, and Torkelson and Kassrs. Hendricks and McCormick review test protocols in the light of new information developed at the conference, and prepare recommendations on a "best value" research protocol; and (5) the next meeting be held in Washington, Tuesday, December 14, at 9:00 A,,M. (as the MCA Conference Room is not avail able at that time, MCA will arrange for a meeting room space in a convenient hotel, and will notify members of the Planning Group as soon as space can be confirmed.) Respectfully submitted. KD J/cj Enclosures IV J-< \1 R' v // Kerineth D. Johnson Staff Representative AS I 00024]7 2 ______________________________________ pii ilion Pounc s/Year Vinyl Chlorido Monorer Poly vinyl Chloride ' ---dueas G Clem. m Hied Cr.cc. Corn. American Cher. Corn. I\ i ,, Cc 77 7. 1C 'Z' 17, J3 n CJ & X cl >3 iZ> 0 XT _ Cl tc *4^ r .io Commama: Oil Co. D _lcir.ona 0o ct* ti n 0c/C Dow Clerical Ethyl Coro. Firestone T & R General T 5.- R B. F . Goodrich Goodyear T G R Great Amer ican Keysor Century Aonocler Monsanto Occidental Petroleum Olin Corp. Pantasote Co. PPG Stauffer Tenneco Union Carbide UNIROYAL 300 17 0 -- -- 600 -- 1220 420 -- ---------------- - 1000 _ ~~ -- ---------------- 30 0 -- -- -- -- 800 ------ 255 -- -- 5065 170 140 70 100 240 155 250 -- 125 240 75 600 90 70 50 -- 150 360 150 110 -- 150 190 350 135 3S70 Total Percent -:of Total 170 440 240 100 240 755 250 1220 545 240 75 1600 1 90 70 50 300 150 360 150 110 800 150 445 350 135 1.9 4.9 2.7 1.1 2.7 8.4 2.8 13.6 6.1 2.7 0.8 17.8 1.0 0.8 0.6 3.3 1.7 4.0 1.7 1.2 8.9 1.7 4.9 3.9 1.5 9035 100 *This column represents the approximate share of project costs that would be borne by the indicated company if all' named companies electee to participate. Since this is not likely, percentage costs proraued among participating companies may be expected to be some what larger than that shown. AS I 00024173