Document aJJyvDaBkjZBwn11pkE1Lx8Ga

LopeI~l~rofl;ct . BL Ea AeA s. , oe: gLoSmipSeie rom lily 11. r-- as aa H. l, F,AS[ vg I ~l, [. LOt(G iW R. A. H[J.SOH Pig 5 R. E. OBER - ~. A. P~OKOP 219-2 21L~),.-2E 218-3 218-2 2)5-3B mm, Those present ~et on April 28, 1978 to discuss results of Lhe ~ d~y adl] Tm FT TR tr 2 te2 studies carried ~t zt I.R.D.C. 1he ~$1~ ~ Of s~t~ ~ ~ usln9 pC erE T itys cSelHTo,yto,TTie iaad rtWeuti plet~ in ~y. ~ up-to-da~ s~tus s~ of 111 s~4~ ~s su~11~ by J. E. Long ~ ts at~ch~ ~ ~se atN~s. A ~le~ ~rt f~ br ir te s,s Se I.R.D.C., ~)~1ng hts~t~lo91~ai ~ h d~ b ~ or ~ly for ~ OLRE RT Ele iY rat s~tes a~ later tn t~ fall foe ~ ~y e~r~tS. SLL pt eT Te DA ALE After a very brief discuss|on of PIATSTSLlt E2n Ego m R yaJor, studies, N. T. ~se, J. E. Long, BER FC-95, ~-~22 a~ FC-1U s~ld of toxicity ~s left u~efin~. the most iI~lmt rtsults fr1~ th~ antml R. A. ~l~n l~ R. E. ~lg~ t~t ~ ~as ~xlc ~!~ F Be5; BART p Ley R. E. 0bet inquired as'to the tyl~ and ~nt$ of Im!~rttles present in TT oF,SitSsyom,, vrs Potnted cut that FC-55 nas neon 1ankified in the Blond of rets wRAH FC-95. FN-3422 an~ FC-143. ~ t~dtles. If sufflcl~tly ~xlc, c~ld cause ~er~s c~cluslon f~ t~ enl~l s~tes. ~rt~ ~ dlKusslon, tt w, ~tnted ~t ~t FC-95 ~s ~n tdentlft~ In ~ b1~ of rats ~lch a ~re f~ F~22. T~ ~estton a~se as ~t~r ~-~t~t ~ an t~ I, Bir Ea Cn ATR ~rtty in FM-~22. The ans~r~s ~t kn~. L A. ~ q~ ~ ~pply FE Ets mri i 1 20 ~ c~lttee ~th al1 available l~fo~ti~ ~ t~dtf, ~t I~ K-9~, ~-~22 a~ FC-143. To L2r)g ar 22R~eCcEe.i:IvIEeOs Ad tng Exo 174 ios 3MA10067059 aon ner MMI vps CONFIDENTIAL - SUBJECT TO A PROTECTIVE ORDER ENTERED IN HENNEPIN COUNTY DISTRICT COURT, NO. 27-CV-10-28862 sane 3M MN00053074 11117744..00000011  rfBo ofiBgrent 0issiati cms i re R. E. Ober raised the question as tO wh|ch fa SE Cemt netSh FC-g5 ~u|d ca~e g~eat~st worker exposu~. ig SSl E ATnB TI relstod to ~ese c~s, ~ deftnt~ Because or the many products BEERiRa Le RRae Hygiene s~uld s~ ~ t~ tn l~ttf~H =i ex~sure ~la~ ~ ~M22 a~ ites he mh hs tt sf rcs In serue and pri aah stn Sd dlS advisable to tissue. Due Lo the sample the blood of (hGhT) taxicity of FU-6. it would rorkers ipotad to FC-93 or related be com. i t hmSramfdsmoriiaeaRSIeEeR ET has been deveiopad for FC-95 18 Hailed io ba sensitive down to4 Teved of i hBiEE EFELtERRtFEi RhT ReSE Rhd EETee REtTTbaDtely SEobe NmyTRoe tTmIerEEeLs A discussion them ~k place on t~vtng the cap~bllit~y ~ ~tll~tq for E G i E E ER EE E ERS E RmEh NE e EER presnt before proceeding with the studies since 1t 13 poasible tt + meta- i R. A, Nelson and J. E. L~ felt ~t fC-9S ~ld ~ I~tf]~ as ~t~ present ~fo~ p~tng vt~ t~ s~l," sl~e tt I~ ~slble ~t m l~~llte of FC-95 might ~ res~slb)e for ~xlc ~f~ ~ ~a E tt~lf. R. E. ~r ~ such states ms su~]~]. (t ~ mg~ ~t a~lytlcal ~rk on FC-95 (n t~ se~ ~ )i~r of ~ ~1~ ~ as rapidly as ~ssible. F S MILSEe R t R1e d 103 sa rm ]t was questioned why FC-95. F1~.3422 and FC-143 were cho~m for the Liem REBR RMR ee, studies, FC.143 and FC-95 have be~ fouad In tee employ. FN-3422 is TR PE Inter~late which goes into a variety of prOduCt.~.. R. E. ~ ~S~ ~t RE inIeTri e t~ year study on ~-3~2Z ~uld gtve lnf~tion ~ ~ ~ff~ts of and ~ss]ble m~lltes, it was og~ ~ ~ls s~t~ ~ld g~v~a further consecration. EJFE S lEiadt nE ib80. Looe ng te 0b im R.A, Nelson stated that ].R.D.C. ts now savln9 monkeys for tee t~o year antml n t sLudies. If we are to use these animls, we m~st p~rc~ fJw~ ~ow at a cost EmR LSPEEEERE Se of $61,280 and ~y $78~ ~r ~nth ~ mtn~tn ~, i.R.D.C. ~nts an ~ns~r s lr EERE H wl Se by ~y ], 1978, If ~ ~ not purc~se aM ~tn~tn ~ ~ys, ~ my M E ~ available later for t~ anlml states. ~r, ~l~e It ~l ~t ~t EL, be~ d~id~ wlth cer~Int] t~t ~ke~ wtll M u~ In ~ ~ ~r s~dies, ER Rh t~se p~s~t rec~ ~t purc~t~ t~ ~ ~t th]~ t]~. * sw 3MA10067060 CONFIDENTIAL - SUBJECT TO A PROTECTIVE ORDER ENTERED IN HENNEPIN COUNTY DISTRICT COURT, NO. 27-CV-10-28862 11117744..00000022 3M MN00053075 -3- PEF ROTON etisa ar sha a Those present again considered the aunt}able toxicity data on FC-95, FH-34ZZ EeLRER E BprTlEity an, and F1~-~43, It ~as ~tnt~ out that ~}e rats fed FC-]43 at the 1~ ~ ~evel ~d ~ut 50 p~ FC-]43 tn their bl~ and that one Ch~lite ~rter ERE AT WtaBeTta rats had liver d~scoloratlon ~f~les ~d ~ne). It ~s concl~ed that the Yi Tal ah ME a a2llv~peosrsssfdibbis]leceohhlou~mraanntio~hneaallttnthhrapptrrsoodbal]es~ssoffcooiarrtelId~nidvwiJvJidthduuaaallssbwwl~ h~o level of ~ p~ ~havvee tthhiiss ~leevveel] suggests ((oorr sab~ovvee)) In their b]o~ for long ~rl~s of tt~. T~se present also co~]ud~ the foisting: AB BLaEiS i T emt eg -- As concluded previously by the full con~ittee, available data in man indicates that no substantial risk exists under the Toxic Substances Control Act. Sr hs However, those present urgent]y rec(x~ended that al! reasonable steps be taken i~edtately to reduce exposure of e~loyees to these COBpoundL S---- It ~as also agreed that: 1BEaat te te ste di R. E. O~r will ~ake pPoposals on ~etabolic studies and ~ke a presentation to tt~ c~Ittee on such studies. R. A. Prokop and J. E. Long will ~ke certain that Rtker has all previous TT A analytical and toxicological data involving fluor~chmlcals in blood. te 2s ements wr we A protocol should be written for sa~pltng of employees blood. 4. ISI be scusaryLS10 ve cet fo tye E35, SEE and It will be necessary to have a method for analyzing FC-95, 1~-342Z and FC-143 in the food used in antra| studies. samen A_ C Su~! tied by R. A. Prokop wrRAP:dr es attachcent ly -- 3MA100~7061 CONFIDENTIAL - SUBJECT TO A PROTECTIVE ORDER ENTERED IN HENNEPIN COUNTY DISTRICT COURT, NO. 27-CV-10-28862 11117744..00000033 3M MN00053076