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Pri EOS ToRt Arps sr Pharmacokinetic Recovery Studyof PFOS in Rats, Argus
stot1e1.n Laboratories Protocol No.
Reference No. T-6295.12,AdvancedBioanalSeyrvticiescStaudly No. FACT-TOX-110.
hTenr4b E h e E teoCceEasepeltl eaebyriontsEPprrn his
`assistance you may desire I in understanding the toxicological ---- information that is being provided.
anintnlptament., or
04008
MAY. 3.2000 11:57AM ENVIRONMENTAL LAB 2 3E 09
|
No.1 P2
|`
Table2: SIanmtpelr-eAsssfauyRPartecSiesriounmafnodr SAtcucduyra#cFyAfCorTP-FTOOXS-1Q1ua1lity Control
Ran No.
PFOS Concentration (pg/mL
Qc
cs
100
100
1 0m | 617 | 12
0212
6.28
18.4
00221160 | s6.o171 | 118822
2
0.216
6.00
18.1
0227
6.09
19.0
00221294 | 66.1087 | 118958
3
0211
597
18.8
0210 5.84
18.2
=7
0217
6.07
18.8
00222124 | 65.4989 | 119739
0233
623
19.7
0214
6.54
196
0225 6.30 18.5
R`SMDe(an%) | RE
0324139 | 939 |
36.0184 | 238 |
3182.87 386
RRESD=[=((MSeDa/nM-oNaonm)inxal1)0N0o%minal] x 100%
NA: Not applicable.
1 NA in 10Dilution)
NA
NNAA
NA NA
NNAA
116 114 u3
N10A6
NA NA NA
316112 123
|(1 in NA 20 Dilution)
NA
NNAA
NA NA
NNAA
NA NA NA
1N1A2
109 n 13
217138 127
.
-_ mnADvANCE= D
SERVICES. INC.
Fags 10011
SIADIATMLDOC
64009
-_--
| o-- s ::
B P$ail = E A A E PROSConceniwrlairgoE innlhrreleea wv
E
3 00490 [0.105Io
0.980
sp iSnEEs= kHEE RSD(%)[ 424 304 L80 5.08 266
[35] 449 780[1] 204
EgRrEees 267 152 198
234
= "
8:g
oe
--~
MAY. 3.2000 11:57AM ENVIRONMENTAL LAB 2 38 09
Xo.1%26 PB 4
:!
Tabled: CSaelriubmratfoironStCuudryve#FSAtaCtiTs-tiTcOsXf-or11th1e Determinationof FOS In Rat
3
RunNo.|_ Quadratic Linear
Coefficient (A)|Coefficient(B)
Tniercept | Coefficient of
Determination
T 2
~00..0000004411594
0.1025 0.1001
3
-0.0006070
0.1046
Me3an |-00.00000042567675 0.1036
Y=AX +Bx +C,weighted I/y'
~0.0006050 0.0004172
-0.0001313
-0.0004533
0.9977 09959
0.9968
0.9966
0.9968
i
i
.
|
I
|
_--
oanABSDIEVCRAANVNAILCCYEETSDICI:NG.
Page 120119
04011 99ADIA03 MLDOC
_------
=
IR m TableS: Couceatrationsof PFOSjaRatScrumSamplesfrom Study APACT-TOX-L11Followingthe 0mg/kgDose
3E
22aes `SaTmipmleing. 1576 Te 157 Tw _PFOSCoRna7 ctenNturmatbieonr| Beni
BB38 e Jew ow oom ow
amo -"w ame om
z:E
8
17" ffooios NNss oooemss NNsS
15 [ois Ns oom xs
o00o5n310 00605
NNsS oNoSn o00o5e9m4 g3 Ns 00610 asses
221 [0J0oMos5 00N7s12 o00u5s8t7<LLQOONSSIN005)LQLOVoISIsS00)9) LUQxUsGI00H NNSS LALLOQOOOMNEO0I00S0)9 =
"<NRSLa:LiNQNousmLabemepssltwe.ihtnhtahePL~oiwdeicLaiemsiptuopfQsuasmtpilret.ion 0.05 g/L).
2
32
-
25
retan
suoeanoc
a Tables: (OCmognitgiDons)eConcentrations ofPROSfnRtSera Samp from StudyWPACT-TOX-11 Followiogthe
g
BnEmG] SarTpimieng]
add
)
754
"PROSTCoanctenNtoramtbioenrGigi)
375
B7sE
=
agz o
7
NNss
0000974070
NNss
37g
on01s08
Te 1377 HE =
xN s o0m067
nNss
BE
3
ius 221
[<LLQ0x0N0sS91(005) <<LwLQLIQO0Mo0I5Em7I4R<(00005s)
<LLO[0.xMNOss1I<(0.05) <ALLLOQIOO0OM0S6MI9}3I0O.005))<LLQOKNINIss<(0.05) 00o005m3s1
aNss 0.0818
5
Ns <LLQ0370]<05) Ns
00592
xs 0050 Ns
N<SRL:aLNQNou~smLmbeasepsrltwehinht2heLownerdLientpoofQeuaneiiation (0.0 g/L).
32
"
28
ters
sommanoc
E
as
Tabled:
Concntenonsof PFOSinRatSera Samplesfrom Study FFACT-TOX-111 Following he 1mpgDose:
E
g
2o ie
SaTmpilmiong, 7 1379
13740
'PFOS CoRnacenNtruamtiboenr T3708 T5A1_Toraip 13764
Tat
13765 T3TASE T3746 T3746.
B
=
F8d55 8
7o
[f9o5m0 NNSs
7m8i5
NNSs 7mme NNss ooum NNsS
asi5 740
NNsS
mm91
NNSs
z= g
5Wo|l|sm8 NNSS 2 18 24
718% Aw
NNSS 22
GIse 20
NNsS 1s
6109d% 30
NNSs 229
2S5850 24
NNSS ism
2ae0s 2m
NNSS 29
&2 E
Zz [13 Ns 147 NS Up NS om NS I Ns oss NS
z
"NRSa:tNNoasrammbpelrwe.ih a T indicales pop sample.
2=
223 - 2
:
~
s
Page 150019
99ADIADMLDOC
B og Tabled: (OClonmtginineedD)oCsoencentrationsofPROS nRdSer SamplesfomSty FACT-TOX-1 Follwihne
=i
8321 STamipe ToT HGS CRonacuerbaie1o3nr75 Gye)
.
22
aZ up0ol offsm oNoONw swiemmr oooNNw
z 2
2a500l[5o3sw uMNmN imssmm aamw
=a5
|
NNS:eNorsavmpi a ieiy
g=
22
b~a
ga
Pecicorts
smomnsooc
=
B
29
TubeT:
Concetrtions otFOSfoRa ScremSamples rom StudySFACT-TOX-111Folinte 6geDose
88 | Sm
FESConettion
=
=
i2 s Tome TSS TSIE T5757 TTS 3 RTaatsNoumb1e3r7k TT T5137 TV TEs
=
8i3 30
w0To oll[e21s2
ooNnNW
iadee
NNNSs CImae
NNNsss
oo1mm2a
NNss m>om1sm NN dio
KNNSSs
om am
g=z E
maBole[[asmmis mNN0Ms MBIsBs BN NSs m2d6z wNNy 1o6em1 pKNsao DlNns B4am aNNS4S s33o0
z25
RoNaomseerswit 2 Pe oper
=2
2Hg
|WS
25
eran
momasasc
B a Table: 1(6ConmtipnhvedD)oCsoencentrationsofPROSinRatScrucnSupefomStuy #FACT-TOX-A11Flowing the
ii
| i Siping| Pr05Concntatin
38QE{08 Time TIE "RaitNrusmbers Tr
`
2=
a
70 NNss 119383
NS
NS
E
3
wo | No a Ns
is NS
94
NS
2
za || m6 1m5o4 N3s
p~Ei
NRSa:tNNoasbueaprlw.ih 2 Fidespopsmple
=
2322
.
5
~
5B
=
Petes
sommsanoc
B
an
Tabek:
RepentAnaisofRatSerumSpe romStudy EACT-TOX-1
gi
2.
aga
NamRbater Treatment Time
s`COoerinngcii.nal
NOrCuiumgbvineearl ~~ RReefasrsosn R_Ceyaopsicnsi.ay NRCueaamsbvseeary Re_Cpugooirnmtied ReRaeCspooonner.feodr
g
3E83X0 Ws 3 Dye umsmeaw 3 1 wm < 4 om
SU Crepe CatQueiion
z=
Eg
RR1E)EAARSSoOOnNNSScFoFcOOeRnRaRRtEEiAPoSOneSRtATcYEe:DdCedOcNlCb:raion gs.
Z2
1)Ron concentrationwit aration ge.
@=
2-22
.
"
z
2
=
@
Page 19019
PADIATMLDOC
E
Table: Concentrationsof FOSinRatSerumSamplesfomStudySFACT-TOX-110Flownte 0mpgDose
2
agp | Semin
PROSComair Gra)
=
3 Time
Tat Number
z
B
(day) | 19501 19562 19503
19504
19504F
19505
19505F_19506_19506F
19507
=
a828L3Rd| 7o f{oownr ooosms ooNssor 0a0msts. NNss 0o08o50 NNsS o03m0 NNsS o005o45 o2C
8% | 1s fomm oom NS <uiood2ioon Ns oop NS oi NS om 3
2 | NS NS NS <LLODO25BJ<(005)0.0845 <LLQIO03S3}<(0.05) 0.0880 00620 0267 <LLQIOGTI<00S)
"NRST:tQNNo=usmLmbeaesprev.ithhFe nLovtersLiftetaolsfaQmpelie.ion 005pal).
Z:
2
be
232
pry
ssavuzsaoc: re
aR0E Tables: (OComngtinDcods)eConcentrationsof PFOSInRatSerumSamplesfromSady AFACT-TOX-110Followiagthe
c=
4
2 } SunplingTie]
PROSComenain
RatNumbers
Z
a0888| em [mow www
T5505 19505F 1551019511 Tos12 TOSTaF
3 a o7 | NNsS cuou0m05m48loon LIIiLqQuOOoMmIi<0o0m9 NNSS 0d0o6c6s4 0o0z61o9 <LLQOaMSI00S) NNSS
g=
-
a15 JoNmSa hs <4Q[0.0454]<(0.05) <JLLQQ[o0.0m45e8]l<(0o.0o5) oNSl 00N6S14 0.N1s76
o02o3m8
N0S2
g
<XLRSLa:NQNo=eLaeemsrsitwehiotnhhFeLnoiwetreLismisttofsQnuanptitation (0.05pgimL).
5E=
232
.
E
~
3S
rutesn
moasasoc -
Ba iE i B Tables: O(mCogntiiganDedo)eConcentrations of PFOSfnRa ecu Samplesfrom Sindy FEACT-TOX-H10 Following the
E-
a8s
GSConceaion
c:
o75s8
517
Toi
sis
sie __osier
E
3
07 LLG CLOUD) 0m NS
.
8
217s |uQon0msMSs0o0sSy) 0ax.0os78s4 ALQ(O.0oN4o8S8m]<(0.05) LTLLLLOQQI0OU.2AM0ZT6IE1(0000.00995))) 0NN1S6S5
zz2
|
"LN"RSa:QtNNua=smLmbeaespsltwehi:alnhtFheLodwiecraLtiemietlofsQpualni.itaion (0.05pg/mL).
=5#2
S228B ----------
Pts
monszsazoc ~=
a------------------------------
H Table6: Concentrationsof FOS iRatSerumSamplesfromStudyAEACT-TOX-L10Followogthe 0.1mg/kgDose:
=
a588 | sumpling ive
FRGS CoRnacteNntraotiorn
= 2
2aga
T5517 19518 TOST6F 19515 19515F 19520 19521 OSA 19522 1952) TOSDF 1934
43 8 7 9|0878 918037 NNSS 963m7 NNsS 9N7s3 8Il2i NNSs 983129 916258 NNSS 110024
7
Hi
a15 [{1NS5 610m7 1N2S1 39198 ENsS NNSS 41431 1Ns2 9N5S7 513059 dNoSz a92n0
8gE
|
NSRa:lNNoasbearpwi.lh ndicates ealsole.
=g
>
g
228
ein
sanaaaoc -
TableG: (C0onmtienhuedD)osCoencentrationsofPFOSfnRatSerumSamplesfromStudy SFACT-TOX-110Follewiag the av
=3c
i8385fs|sumpli Time 553 19575 135361P0R5O7SCTRooastamNVneobetsr 195% TOF 5530 901 TO
Z
358
58
&e
o
57
{Ns 10
N[NSS 9do6o
os
1m172
120 100
8e7Tos78
Ns
NNSs
me
31013
Ns
NNSS
871468s5 971510740 91100616
z22
3 |da NS ON NS an dos doe 104 NS NS NS
g
XS:Nose "RatNumberwith"F*indicatesfetalsample.
=g
23
E8 ~
88
rtracn
maoasoc -
a
E Table: Concentrations ofPROSfnRa Serum SamplesfrouSty AFACT-TOX.110 ollowia the84mg Dose
8n08op |s|u" mpligTime
F705CRoatnNuombrer
@=
Ba2EgBg]
15533 195T3F 195% TOSSAF 19535 19536 _19536F 19537 19538 19539 19540 T9541
0 [ms ns ees ms su ams Ns se sss 62 eo Ma
E
a2a 57 0[433 NNsS s5e0l0 NNsS m5626 4636 NNSS 5s0h7e sLsl Mms2 dssea ANSS
zzg
2 24 5 05 44 NS 162 22 NS NS NS NS NS
2
NTSR:NNoasmameplwei.h Fes a eagle
z2
-
g
g22
rita
moan
~~
8
90 THe: 0(C4onmtignuedD)oCsoencentrationsofFOSInRatScrumSamp fomStadySFACT-TOX-110Following he
=2=
8253 |senpting Te
PEGS CRoanicNeautmiboenr
&E
a8 ka
155 T9563 19563F 19544 19545 19546 TOS4GE 19587 19548
5OE48 07 fm[4s3 446613 NNss aGs8s NeS9 m4ss NNss a@22 @moe
=2 5
a5N 40 BB8o3oNlS NHsI oNNs 4u1a3 aNeS ew3 esmro
g2
NSE :Nosemple y
85
2
"
228
Patras
[-- -
&
E Table: Concentration of PFOSfnRatSerumSample fromSy SFACT-TOX-10Fllowingthe 1.6my Dose
=
8a0g0 |sumpingTime
FIGS CoRnteNeurmaiboenr
-
2431
T0585 15550 T5551 19557 10553 Iossa.iosss 105561957 19% 195991950
g
8338 a
57
6NS 026 mNSm NlSs W0m Ium 6U65 I1 lNSw 1m9l6 m 10 217 [Ns d@ Ns ON Bs ms 25 om Ns ie 1m 2s
=g
aN ON ON NS NS NS ONS 3 NS NS 27 Pe
g
TSNomar.
2
o3
gig
2
8@
Peco
momasasoc -z
Tube: (16mCai oDosentunofPeOSdimR)aSCcrumoSemnplecfroemStutdy rSFACaT-TtOX-Hi10Foollonwingsthe
zg
P8 n
FSConcmiation
=2
2 `SamplingTime
oBG oy) [1oS60F Toser
"RatNumbers
Tos loser 19563
19568
2
87ar330 5o7 NNNoommm woosem NooSNN e uwsm ms11m no fmow er mow a
22
gE
NR S:No v maple Ts
g5
23
B -
88
he: wn
apmamioc
=
=
--------
=
Tables: ConcentrationsofPROSinRadSera SamplesfromSandy AFACT-TOX:10Follwiagte 32mg Dose
8
2880 |SunpingTime
2
1556519566
19567
19568
PEGSCRonactNatutmiboenr T0360 19560 1508
[5570
15571
T9STIF
1557 TOE
7 g#
FS4]iB]I 0Tomfm oowm uwe ouwm owNs ooms NoNs mmoome owws wam mws
.g
[13
2Is 3N4S5 O3N1S1 2O9NS4 u33l6 mNsS 3214 NUSe N26S9 31685 N1S6 31137 N16S6
=2
RNSa:tNNuomsbameprlwei.thF indicates Foalsmple.
2
g
282g
Pre
e------
=z~
&
--er ------------t-- l -------- i --I-- .
= Tables: (5Com3iagnedD)oCeoncteuons fPROS atSerumSemplefromStudyAEACT-TOX-110 Followingte
4g
Fi8
FESComin
i 25 | sampliinmg Bn Tow RatNumbetres To
Tos TE 5
Z&
3521d 0Tomfm m wm mwm oNsw doww oowN owms owew oNw wom ow om Na Nm oN ow Nm
22
|
4% WOW oN om om nN om me
g
SToep aTT
&
3g2g
-------- HE------
Penn
A
5g -
9ADIARZMLDOC
=