Document aDLzGmmdRj18Kpgy1XdQO9nKB

nuaust 24, 1965 Bernara R. ,3rodis, Bh.D., Chief Laboratory of Chemical Pharmacology national Heart itute National Institutes of Health Bathesoa, Maryland 20014 Bear Doctor Brodie: ily attention, perhaps not remarkably, has been called By more than one of my colleagues to heferen.ee -p27 In uhe article entitled ^Toxicology and the Biomedical Jciences," By yourself ana associates, in Science 143: (No. 2677 for June 18) 154771554, 1965. "21. it is known that . . . 2-ntohthylamine and tetraethyl lead are converted to carcinogenic compounds. I would suppose that there is, or should Be, definitive evidence in support of this statement, since tetraethylleac^ccupled therein with beta-naphtkyfamine which has been so thoroughly convicted. However, I am at a loss to put my finger cn any evidence, either experimental or clinical, that would render the statement credible. I would knew, certainly, if there had. been cases, of malignancy traceable to this source in man. It is entirely possible that I have missed something in the literature, since I have been pre-occupied with many other matters in recent years. I would appreciate your courtesy if you were to enlighten me on this point. The issue is of much more than academic or scientific interest and importance. Cordially yours. RAKsrms Rcber Kehoe, M.b .