Document aBpOVwGbobnOd29eYpO2Kp76b

COLLEGE OF MEDICINE. EDEN AND BETHESDA AVENUES KETTERING LABORATORY d epa r t men t o f en v ir o n men t a l h eal t h University of Cincinnati Cincinnati, Ohio 45219 December 2.0 , 1973 MEMORANDUM TO: Faculty FROM: D. R. Johnson and L. I. Kleinman RE: Grant Proposal We are planning to submit a new grant to NIEHS to support the investigation of the effects of lead on the kidneys of young animals. Our primary concerns will be the following: 1) can the animal model now being used in this department to study lead-induced brain dysfunction be used to study renal dysfunction; 2) can lead produce renal tubular dysfunction other, than the reported Fanconi like syndrome, for instance., altered sodium excretion, urinary concentrating ability, or response to an acid /" stress; 3) at what stage of intoxication are glomerular function and renal hemodynamics affected; 4) do any of the above parameters correlate with blood or kidney levels of lead; 5) does infant lead exposure result in incom plete renal maturation or dysfunction that leads to adult renal failure. This research should provide some basic -information concerning renal involvement in pediatric lead poisoning. ' j . 7 00806