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AR226 -- 3274 456 AR 226 - 3274 --_ `TRADE SECRET Study Title .-ovicToxicity 90-Day Oral Gavage Study in Rats Volume 3 of3 Laboratory Project ID: 'DuPont-9478 "TestGUIDELINES: U.S. EPA Health Effects Test Guidelines. OPPTS 870.3100 (1998) PN AuTHOR: Gregory S. Ladics, Ph.D STUDY COMPLETED ON: April 1,2003 PERFORMING LABORATORY: E.L du Pont de Nemours and Company `Haskell Laboratory for Health and Environmental Sciences Elkton Road, P.O. Box 50 Newark, Delaware 19714-0050 Wonk Request Nowsex: (SB service Cone Nowse: (I) ~ C-- e ------T-- rem ores-- e-- i-- ----p ------ [I ---- ~ EN 3333333337 33833333 33s oH HE seesssesss sesmgesmss spsEessEss C.O H HEpELmppHerr I smampT nsmnr T srmerE esss pt abefied afeeeennd. cobibd FIL I | i Fi | BfaFr BBiMfEppHzEmmNr pHmIrmNamGeeEs mmremsgmmaeens RMIT RIMM IE ) gi 333333323% afIdNdmEn unm His ERE2 RE : Lai jie {HH a FH HIER LHL : jasseneiyd : iE 8 95 szsasgzses spgagrzsss szzapssis =i 8 33333IIINIT 9399933 + Hgppeiserdeer ri mmzmE ene PEf mme mm mmmmE mnee p ohp eanede BrLErD EEEge Bimmer mmmrmmenn ; jr rasan amEanIasE ) BnRIIIIEET B3INEREEES FREER sRTHTTH EHR R:I EHITE | GREELEY 2 ii i s538g8esss ssgsneants ~3 i ~i i i 3 3 : 3 2 : z: 73 z: = i z i H BL7 zmsernrmzarsaaerssss g esswsascsas .3 saeisanies Eg o asumssscss snssgsssss sassassass 3 i i 23888888888 i SE822885888 3 S888888888 CompanySaiized. Boss no contain TSCA CEH ~3 i ~ 5i i3 i 3 2 i i : : 3 iic 3E 3B z# AB98SE8IEeLmEsEsLsEaLsEiCcd aR| MIcEErEsE fEEEsEsEeEaDn 9 2 2 i i $885838888%8 i 23888525838 [SS ---- i _| 8 2333333333 GE gepEnese ;PoRHEiEnamsna gE53 ofr vofponfune DFo ROmGGmEmR 3333333332 igesesezens BdauGm aseenmaeesenseeesss MonIpNmoGn 3333333333 HE regen eee dgH na mH 5 aeeaeziest nooo 3i 283232032 22222012 bdkh kik ' 22 ag2sae3sss Se anIa2e33 33sdnes: TI rp omsmsdiems b alsdsasned naditened iSs v] IHG 3 EGE BE $i ~~ 2 1B5 ERsLasEppHsaHss URR osH nneEssnHnEs R| sussnnuan i 2828888888 3 22882888388 3 S258883888 i 83 II33IIIIIT SITTIN JsrH prezer ppmnnn sCOo E BEEEEH .mEEE HmErmTprmHees 1B BPemnTeeTns ILEIIEE OEE | iDae m imimm mBRmRo ; ii dRRRRRER 2223223322 ' 84 33I33%33 0 I3NoSAsEs: El o0 o qsssnmes ominanins 3 3 i 5 Hi] i SEEEZZEEE8 i SEIEZ35538 ~ 28] i 3 -- 2 a i i: i : ; i E3 E i{3 2e3e8e2r2a3n0e8n8s3n {2 sgoemangnieansziecs J nmessgenrnsziaen 2 i : 3 4 Bel ovaainiiiog B3ES3Iaail si iis s cob conassasss snssssssss b nassgcsges CompanySaito. Does notconTtSaCAiCBnI ~3 i ~i g 3 i 5 2x i2 is i3 i; it4 5% gsxeoeffeoieessssy { sasjiessess 2 z & 5 Be op 3329783473 + dairaiiais H d 3i% $25 un5s3e3u5zarnsazase C8g gsamspamssnrazesssss lS 2 = 8833338888 i 338838838 Company Saniized. Doss notcontaSiGnA Gol ~ z: 8} 3333333333 33333333; og HBEEHnnETEm m Hm Ta T 2POH gesgasessy gHeEprHerEsHeeEs FE5 mewerenndIl oEheblenn Tae DEBEEBEENT PUNE BmBnimn 4 3 IIIs nnn ) i #1 I333s3Isds sdssduseas [RIE RH EH HERR EEE EERE i 2 33333 ny 23 8 SeeuEseine 2 EEEEREEEEE < 74 f 2553533883 | CompanySarin. SoeeconTSA ~3 --~ :: 3. i i H Be rmnanien i IEEeENEE 2 : 7 3: g . i EiE3 58p 3i s2i3g2d0d3d2s9a3d2s2 ; B2e0d39d0d0d0d3i9s2g 3= 2 2 2% gemznosesz gppreressa BI; HEgEpnamr | rmia 3 2 S83TBLL8I8 g SITEIILILL CompanySantas, Doss otctsinTSCA CEI ~ 3 83 F32333337 0 JIIIIIIIT- RRRIIIILE spresresr ms spasms srsrsssses TOI BFHHH HD Lio f GfEmpn rmees T emsmrE mmes sR rssrsR sess PYs HmBHmEHmE SomHmEnrNeGr H rmmi een ~ | 8Dae mHEmRmE mTRmEmE pTrnRmeEerEn ; it 22222222722 IIIT JrPTRILIN: ' B27 J3343203r% 33v9%:3ysr nImydscei: EERE RE CER : i i i s 1 HIME HHNNN | HEHE ~ 3 $f IIIIINIID S3EINIITED vo sfpirie mmm ; EEEEEEREEE BEERRRESR J EDnOnEREREEEEEEErE rmororpzdnedcEeE PE BEEEEENE GEE 1g JRpNpnger pensmauss _ i F QRREEREEED fmsndandd i ii J23322%232 3333323332 ' El 3 333233diae 332333383 :5 3 ;: j35338838 s} sehraeassantsaay E2 EC 3 EH Fi EER3 EH EH EE f 8 f SopEplpgEasil;y | BIpiEEiEguRin Hd ii 2358308888 s SRS8RSRRES CompanySn, Doss etsemanTSCAGH ~3 3 3 3 g 88 8 ii :5 t:o og [PI r 13 I Z i 3 asl iF] ir og 9 i :2 ii P2o :i bE $ % guneangans F ssgsanszie GosEessnos S 35 : 3833388385 . 25933I8EEEE . sgIIaGiN: Company Sails. Doesnt cotsin TSA CBI ~3 3 ~ | i3 i5 i 5 I i i ; } g| 2 3 2 : f 3 saznazezan f smnseenias S| 2g| 4iEf %.F4 RS3Eu3S3EH5E8C5R5ER3S3ES2 R 4. SSARE SRURBZIsE sRgEaSxE Gompany Santzed. Does notcontain TSCA 081 ~5 A 8 3333333337 133333:303 sssssssees ohn nie EEREEEES ge HERE BeSsinmsse P ; G BnpE mn pHRpIpan oHmE en Ps RgOmmNon B oamC nan smaan Pe BHpImEz mmmmoarr mmm -- Fi Pdi pte smn 3 it 2338333337 333333333 33333333 ' gd 3233333358 ai3zaaesns 33333332 Er roam tonne pmiOn S is o7 R i C IEEE HH H 35 3533328585 ; 293IIEEsES : 22333333888 ~ 3 85 33I3CIN0ET 53303333 oRgress pienn s i if bid pT a E P5sHm HH mGmeHmeGss ~ | ia F HE. ; Pa mmm assis ' ge 2 II3sseanar jaEsssdni: 1 mi ail :wing i2 E2 EE 2 ER EE H i J ; BE52888553 ~ :2 i = i [J id ig 35 Fs 5s 23 3z I : i BE i 3 LE BE} savmaanaen sasesasied 3 sazEagags f je ; giao 3 3388328 5 ShBiaaiel Company Santas. Doss ot conan TSCACE! ~ i; 3 ~ |1 8 i i 82 8 iH BE OE z i: 8oz i3 2 3 gril; 3 FH i I ganansagas i fangeiafii 2 :8 fge e . f: 33iaiezaaerbebsadsn = 3 fe3sieptihailnied Company Sais,DossntcantSOsAiGBnI a 2 gf 83333333 3333333333 Togreieses pare peers Pos dTeT in pHsi pre parnenm ~ | DFare oCpHEmE BpEmE s it 63233333 3333332383 } ge ~ g8325302d . 33333333 Toe rosa | snatsiaans ~ :2 ~1 t 3 g : ; 54% 3 i sag88e8d2e52z3z3s5 T3e3330083 Bgodsdsads = E 8 5 aTsaza 2Mgrfu oSf RoRgEsNsIuEoeiszes + IGas8iia8Na5iai8s4sd 2 i esgeiegy ssggesgise ampany Saitzed. Dossnotcontain TSOA GBI ~ i i ~ 3 2 FE cemnomann ceemnneane eameenannn i aman & i: iF pe | B Hod ? i - en i 2 B CompanySaiized. Doss notcontin TSCA Cal ~ a i if HAmnanannn omanenones { ig mmaanaannn amacmaneas H Nn Ne HF] i i ol : Fa : H 32 333083988 23padiisd `Company Sanitized.Does notcontTSaCAiCanl i | NE c lmnop i z A 2 2 2 73 f SES82280EE sosrssseas i SEENBEEERs ~ 3 Co 3Col fr Hos { : ~~ :a "= & " if TE i I i i EH i eoecoBocoo i ccesccscnn 2z Bif ; sjeGg3a3giaagcgissds | zS8dcfigsgagsaeisays ~1 : :i LH --~ 2& | 5 g 3i 3| T | Ei . 22 88 i 3 ig coccscscse scscsccces sesscescce i ii PT mmmmanmans maamann Mrrno Oo Mn anonooomnoe ccccomonme 3 3 i Yl ) : : H iF S swsazsasss | oasszssgss o 33333338: CompanySeiten, SoatvaaTSAGB ~ z i ; ii i : ii : ol : Hh i --~ cf fi i H z i iy 2 g] 8 3 i 8 ComprySita. Onsetcoma 50m ~ ZzZ| g Po ; i x fy ~~ 3u ~ iT Poor on i Ig 3 Ino) . 8 i 28 8 3 PE -Be83o3ed 5-388883-3 --3-8-B33e 3 38 aeBeEeR BoBBREBER ~B-B-83- Po -B8-88-8-8 Bo8E5R%EeR ooB-3-83E- :g :7 -gonge5o8 1 308352888 :J ooB-3ou3se Is ; ; Pb 3 emeesieen J awsannen operon. J : -83-83-8-3 : 1-882888-1 ; -3-8-288- E] 8 3 8 Sopris, Soar ~ z i {3 ~ | i |: i| ilf ; S2 F 88ec8o88e8 cocooBeBe- i 8 BBrBeBed anennBegen Bo, 88 B-BBek cnvnoBegn z i 2 : bog oseenenier J oencgeges 2is ET: ggeegegzes !ooococgotes : HES URINE 83 $ i FETTTTIITTI $383833553 GompanySaiizad.Does notconTtSaCAiG8n1 ORO 50DsD yOralyGavaO ge Swyin RGas w iciegeSudyinRpuDue opomnots 9s47n8 APPENDIX L INDIVIDUAL ANIMAL BIOCHEMICAL DATA -- ~ --_-- Gompany Saritzed. Doosnotcontain TSCA 081 O 90Dsy OrN a CavageS. ty inRats Toxicity Dupont9478 --~ INDIVIDUAL ANIMAL BIOCHEMICAL DATA IN MALE RATS AT THE 10-DAY TIME POINT TTBeta-AvimalOxidatiRoatn e_ Group Number (nmol/min/mg protein] 655115 655119 655124 655135 655137 13.71 14.73 16.45 14.21 14.97 m 655144 655118 655120 655132 655139 11.31 1343 15.37 15.52 14.59 Vv 655121 1835 655126 17.77 655127 13.89 655131 15.53 --_ vi 655138 655112 4.12 16.17 655116 655125 1427 14.32 655129 1334 655133 15.19 xX 655113 26.88 655122 2523 655123 26.16 -- e65s51208 o17e .65 --_ -_-- `Company Sanitized. Does not contTSaCAiCnBI O5R0Day Oral GavageSyvin Racts Toxicity Dupont9478 ~ INDIVIDUAL ANIMAL BIOCHEMICAL DATA IN MALE RATS AT THE 90-DAY TIME POINT Group Animal Number Beta-Oxidation Rate (nmol/min/mg protein) 1 654928 654929 654950 654972 654993 12.52 13.02 11.22 11.35 14.00 m 654913 654938 654941 654947 654995 15.49 1241 11.97 14.65 13.25 Vv 655005 13.02 654907 11.62 654959 11.01 654961 13.92 --~ 654980 18.59 vi 654922 654930 654940 654975 655001 12.69 14.15 15.82 10.15 14.04 xX 654965 654979 654983 ems 654986 22.46 17.74 23.81 o1i7.s57 Pe ee ---- ree Gompany Sanized. Doesnot contain TSCA GBI -- DayOral ; GavageSycinRacsToxicity Dupo 478 ~ INDIVIDUAL ANIMAL BIOCHEMICAL DATA IN MALE RATS AT THE 3-MONTH RECOVERY TIMEPOINT Group 1 xX Animal Number 654994 654992 654909 654924 654943 654978 654974 654985 654990 654976 Beta-Oxidation Rate (nmol/min/mg protein) 11.86 8.05 11.90 12.53 11.59 12.48 15.32 16.42 17.03 13.27 --_ -- = -_-- Company Sanitzsd.DossnotcontTSaCAiGn81 CA: Tc ~~ INDIVIDUAL ANIMAL DATA IN FEMALE RATS ATTHE 10-DAY TIME POINT Animal Beta-Oxidation Rate Grou Number _(nmol/min/mg protein) I 665555114419 2241.4938 665555115525 21491368 655159 238 TMv 665555114620 2237231 656555116642 22134568 655165 19.99 vi 665555114405 2196.6116 665555115548 2199..8616 655167 2401 vm 665555114484 2B4257 656555116631 2211583 655166 2702 x 665555114436 665555114570 ess 223796 3304.4153 wn --~ -- oe Gompany Santized. Doesnot contain TSCA CBI O "Day OraO l Gavage d: y in Ras Toxicity -- INDIVIDUAL ANIMAL DATA IN FEMALE RATS AT THE %0-DAY TIME POINT Group Animal Number Beta-Oxidation Rate (nmol/min/mg protein) Io 655016 25.67 656355007391 2294.6054 665555019087 2208.1703 v 655040 2500 655041 2598 655044 24.60 655086 24.00 655108 27.46 vi 655029 30.69 655034 25.64 655038 2524 _ 665555003349 2271.3363 vin 655076 655047 655055 655058 655105 2880 2824 33.60 3241 2535 655097 X 655026 655052 655063 655103 a5 35.00 42.79 33.28 40.78 Duonto478 -- -- Company Sanitzed. Does not contain TSCA Cal -- "Day Oral Gavage Stacy in Raitse Toxicity INADTIVTIHDEUA3L-MAONNITMHALREDCAOTVAEIRNYFTEIMMAELPEOIRNATTS ---------------------------- Grou Animal Number Beta-Oxidation Rate Vmin/me protein) hid 655035 2378 655015 2161 655009 25.06 655068 2375 635062 2462 vim 655088 2591 655077 2538 655010 3242 655030 18.98 655049 32.17 DuPont-9478 -- J eT -----------Company Sanitized. Does not contain TSCA CBI O-- DiyOa-- Gavage Slyin Rats Toxicity ~ Dupont9478 APPENDIX M INDIVIDUAL ANIMAL BODY AND ORGAN WEIGHTS ~ -- e--e--r----------------w--e-------------------- GompanySantzed. DossnocontTSaCAiCBnll Doo pEmmnE OL IENEY 3 Ho Ei giEzEmEmsIrEeamLanRl | %iagasem gh ~ Del gg 1H8gi1a5z3a33z3a0z%a0s0s0 sa 851 gispiiTsiniainisois 3 % D3 [gfiRERERLNERE SR. ggiiReSEIEY dg BREElg Baia 3 0 ti iiemass7sipsmmessmrsl o mSSas AY ~ iC00R1 Egi=yEsnl || mgiissssssmannass a5gi PopEE pEmmEan "leGi L BS iE n m fimmmo s| HIER Baesn Jy BE Hime 2 gil PEEEAEoag bpammmiEnmiRa Ef UY |I0E3 RiIeEeis Be 1agiasseaneaas ex) mmm, : |p BEE pies reapris ~ E 3. \"Zissersesszazs! | Zizssssessal CL GJommmamomn DE psa En HOGER EL m dammmn pHEREL sas HL REESEBL iat CL Eanamain Laman gid (77 BEEEEEREEL gi 355 3f3g P|| odaigg hinii sEaiiaam nsnaanm agny: e rAEx fit gBPfHlrmaaenanl 2s PEERELDas Bo lmogmpman oumsm `CompanySanitized. 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Disp 8c9838838! 3 Bl Cy mama, Cidnme ersrr ~ [PEEEhSea PERE A He EEE 8E ~ ldyd RferiIg Ezs! piu ig 12 Pi gl El Pd i 8 ilps i[EERE E REHE | Poi E i IEEE oN BEE i: :: i CompanySanitized. Doesnot conTtSaCAiCBnI ~ : 2 ii Dob i, iansasssaasza! | izassaszal flasecaidais ail | fsa) Po Eenap gies) ial ge gee [ ighysRazsaiade en ghitanenatt PEs oe TRS i maarnel | rreaane pl gina Tolai3n30 lapg 3iEREmEREeEEE eBB) lpe.oBsEEeBsE 5: hpi Eg mHEE (PE Re 2 | REE pa io A a ia 3g & || gl i iiENs EAEINEE RE 4 s gRREmIIEn RE) 25) 0 dltlresacsnis sri dif iisesaneal 5 |B gidEEEEEE Eh EERE 4 B3l Gl 0| | || fifF iigseeamananmaneasEsmosii oiid7imnzmaaszeeiamsl piEisREERneosg esse) of [ES ---- ~ 51POiwpRwE pDireaanmanEn Pome hE PEE menia i i i738 EH Fy asa 43 gWCd oISnEEaEw REomamne ~~ igdi i8giSE 85 gpiSaRBinniss ani yA Bessioey EEE RE 3 Pod Jolmmm] ff | ceremonies g Brp dnsEE gphimmtmmamasg i002 1 zz ssl 1 issszzeeszs sz) 5 4 i i z i is BH Hi jdsdsdsdsas 33 i g ETpl er TE ymE mmE, i CompanSoin, oot cronTSG ; ~ {0 {ff | giasEEssasss Bisdsadesias ii AZ | gingspiEeiii | lissnastis) popu E pum p jogplEo EEIEEm GD Gp MdeEesEiERnED DJil m EssatenE aes ar E E namn avan H[gE83fH 0 L(| [EAM RSmEt IAmRo AGeE e nAFLBI || LE NEL fAEReaizsgeessiasny) ' C U3 lgilemensmei easE aa3l | 5a iseasR msaas gp gp EEE aan H S Ei E LiEgm ii-m%m meigmip8aignnai i2| ap le mmn ane a gopilmaan Bl ppmsgEn Conon Sorin. sos tc TSAGo ~ A. PPoolldaneaE E HR LEE Pol igiEoa Pal gC ~ di ooatE Ir [EH A P| Hodis E03 ifs oF el i 2 [BFS EE sei dl | gad S| xii EPs oE REEEEe ; ' 1i: i 5: CompanySaized.DossnotcontTSaOAiGBnI ~i Co himmma imam [ gpummurn pina Dammam po pEEEEIR IEEE iE pmamm pREa EE ~ |mmma m poama mun GHD ieiises nL saaean ' 1B i aEAanEE 2 i dianiaaann EEE oe | panm gna | hssa hss 20 Ho a jl afm gam J 3 |Poli rog iani imERl mENpAt SeEs sNE lHa@pi pipammt EaREt eRErE 4 Hol E| E| r Gig |e zagsr sssEaeLlIHTibg lissespsrgsaoElBI f fl | plHEHE pf HR me mp g ~ PPooshiEeE ~ | H THERmEE EE sn ha Ee Cop Po iggly B32 gl : iE doers is | | ig ELE gH l i |c x p if iig si dF ire i: :i i & i SerbSom ~ 3 *| 1P1o IPT;ElzEzaEseRneaeEvSE--s EEEE iJE"; l-- szanagnas| Do pEmamnn am {1 TsimpgeanaanrEi DPLonBeiEnHHeE nGp {gl iB igsssenss mi PoE {Tisdssssds di fa | 5ipeRmEnIEE ETNE iE lnmimamemal [Tjisssssdsss 8 En gG i Paa rrrmrm rrmvra earrtBl s Ehl Pnraevnrrneaen] : ig8i [fpigSiiiisz Bi fp EisEiisad; 3 [pI pie # [I He oi 3 f1snitiiy . HREERE EE Bl | | Gigizmmemena.,s. Gif omenaEEl go HE JRE fiijaemenas; [SP ------ ~ Pon Logie Co iid E LI p Ed l o go Bl E | aE EEE EE H BELT aimcas! gl Po EileEcE i Hg is n Eden EERE Pp SRE ERT FE i318 } {IE RL A 8 , ii i i Ssoa, Sma 3 5 i i HH Li iiiE ~| R i351 = P18}8 PE El i Hee wel BL fgg mam ui nian i EReil 0 33 1cess Esslg3 pleisscoss aangi }. gEl L| E BliT nasT I mBao ini e a BH ii Bl 0 figlsemee| TIT lnsuay i CompanySantis. bes econTSCAHI ~ Po ia ~ | iE 1(E81 igi ! PE |8 I frm Era : Su 3 0 10 [pr IEBISSIT GEL9IS)E ETIEHBINELIETS 3E)Y 2335 |i 1%3) DlaiciIes EweEl 58)1 gsloaemmes asonl }4 BEih DT : S| Gig jssass i Cig izes | | Ape pa : : Company Ste, oss etsatan SGAGB ~9 1 id Io 1 ~ | i134) i351 L(5Hd! OE PA iLS! iIfRE g| RyREA EEE.AE M 3 dgliginanana g88l || pti i<eigiEclaeemassss| : ' 3: ii: Company Sanitzad. orea osnan SOA GBI ~~. IH Ln i= --~ | 3 3] FH ; ' (a8 i | 1 pi TTT TTT Iie Hl ; ! 25 00 G11 dimmer 3) Bisadds al def 8 Eases gi giaadid oa 3 i JBl | i REiEiLiEsEsEisRlEofniaTpiiTiaanmaaauon! i5 BL isms Ci aes i Som Snnn Doesnotcontain TSCA C81 Spam GEER EHEi } ~ | iH gE iF oinE s| 3 iE 7FE Lal | S PIRTEHE LCeEse BH laas al :. 22S0 i 3 piEE[iAzdsAsdsed gAdi) H3iidirgemseeestdsadl 4 EEE rrBE S| gE EEEBp EE i i orp t,o corsa ~1 Pg La [di ~ | iiH ig 123 RH Li a EERE | 3 fl Poeloglo Eg mmm i Ea 0 piEBiEEEEE AY | 5 dimaeny Do Hpi a 8a]] || | FiE% j[E8E8E3E8E8 Ad83! 3 i i : Company Sais.DossetconTSaAGn1 90DayOral GavagetudSyubienhRraotnsic Toxicity -- DuPont9478 APPENDIX N INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS -- 695Company Sanitized. Doesnotcontain TSCA CBI C"9-DaR y Oral GaY vageStudyvin Racts ici DuPont9478 ~ INDIVIDUAL ANIMAL GROSS AND MICROSCOPIC OBSERVATIONS EXPLANTORY NOTES wAeccriediennatdlvyerktilelnetdly(iinncjluurdeedswahneinmablesipnrgehsaenndtleedd.deaIdn-loirfemoarnidbnuencdrothpastyhfaivnediinngjsurmeadythbeemusseelvdetsoomrake this determination.) LesionGrading sHeivsetroiptayt.hoTlhoegidciasltrcihbauntigoens(aerxetednetsocfrtiibsesduaecicnovrodlivnegmteontth)eiisr imnodripchatoeldo,gwihcecrhearaapcptreorp,rdiiastter,ibbuytion and ampopdriofpireirastes,ucishaalssofoacsasli,gmnueldtiafsocfaoll,lodwisf:fuse, unilateral, bilateral, etc.; A severity score, if * nMionrimmaalll:imitthse. amount of change present barely exceeds that which is considered tobewithin dMoieldsn:oitnprgeondeurcale,tahneylfeusnicotnioinaelasiimlpyaiidremnetnitf.ied butoflimited severity. The lesion probably * Moderate: the Limited tissue lesion is or organ prominent but dysfunction is there is significant possible. potential for increased severity. ~~ * Sinetveenrsei:tytohreedxetgernetetoofexcpheacntgseiigsneiiftihcearnatstiscsoumepolretoergaasncdoynssfiudnecrteiodnp.ossible or great enough in Comment: gcroandteisnumuimniwmiatlh tmhirnoiumgahlsleevseiroensrebperiensgenttheprloegasrtessseivveereinavnodlvseemveenrte/sleesvieornistybeailnogngthae most isnedviecraet.e Wthheiilreretlhaetigvreabdieosrloegfiecratlostihgneifmiocrapnhceo.logical characteristics of lesions, they also (Gross observations listing multiple masses foar tissue are distinguished with letters (i. a,b, , d, etc) `Neoplasm Designations "B: *M: BMaelniiggnnannteonpeloapslma,spmr,ipmrairmyasriytesite --~ - Tee Company Sanitized. Does not contain TSCA CBI O W DayOb n Gavy gePc odyo inRats.u viOwptuinoR Duwronee 94n78 --~ soo (assSnhtaosveing anIinmdailvidduaatla AfnoirmailndLiivsitdiensgl animale Dose Grow +01 0 na/ka/dsy Sex: Hales Aoimal nf Wicroscopie & Macroscopic Findings Gin EKTxeiprlomlsieundraelonGsbaracoyrwif:+ ic53eS0DKY Alaa Lo siamed off from necropsy Gross Pathology : No MH"aLcOSrRVoRTRs,,copKBRiIADcINNEA,YbSn,oSrPLmIIaNNAlGLiSt,CyORWODEb,AsReTrS,vTOeMdSAKCEHL,ETADLUOMDUSECNL,E,IESTPOLNEOEMN,, ROTODLREEE,I,ALSAPGALLNIACVNRADERSAY,S,GSLACCNIHDONSOT,NI,CMANCEONRLDVOIENB,,SLAPRREICTRLUUIYNTP,AHRYNERGOSDLREAY,NFDE,RTZHOCNGLSW,MEH STFERHMYAIRRYNONNLGLD/LVGARLRGAYINNCDXL,,ESP,EAYREUA(RT8IH)NYARWROIYITDHBLGALODAPDNTEDIRSC,, NETTRRRVSAETC,EHSE,AS,KISNPB,ISDSIBPOHRVAOMGSIUTDSAE,FSE,, FERKgs J0TNT, STERNGR, NOSE Histopathology + - Laven`I+ rLARTION, SUBACUTE/CHIGNIC, mininal. No MiBTcROArNIoNEs,cSo,pGiEcILNUANAGLbSm,CoOrRNmDEa,AlRiScS,yTOMSOAKbCEsHLe,ErTvADeLUdODNEUNSGCNL:E,JSEPNLENRN,, ALOERTNA,, GSELARALRNCIDRVSEA,ARSY,SCGILCAN2NCTDUISMC,, NEMCROAVLNEOD,NI,BPUILRTAEUCRTIUTLMAY,RMYEHMGESLNEAONNDTDEE,.RITTCH.HINLRGYSWO,PHGADLNROADEDEN,,AL GSEYRAEER(AN5AT)RHYVWRIBOTLIAHDDDOGELPRAT,NIDCST,ENOETRSEVRSEA,,GHEBSNPK,IAD,ISDOYPPMRRIOADSCETUSA,ST,E,FEPSNREAURNRV/TGNAREL/ELVAESRSoIIRDC,L:ES, SERIO, BOVE WARAGH, NOSE --~ CompanySantized DossnocontTSaCAiClnl ( ayOf O CavageOU inR-- assic icy DuPone9e7s -- Showing anIinndailvidduaatla AforriziandiLviisdtuianlg animals DsotsoepyGroup + 124069m1a//mkag/ldeay Sex: Males Ania Raf Microscopic & Macroscopic Findings 54505 KTeirlmliendalonSaDcaryif:ic16e3 AEnxipmoaslureisGrsiogunped+ oRfEfCOVfrom necropsy Gross Pathology : No NAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORHODEb,AsReESr,TvOeMdSAKCE:HL,ETDAULODMEUNSGCHL,E,JSS7PCLNEEmNv,, ANIDOLDREEED,NN,ALSAPGALLNIACVNRADERSAY,S,GLSACCNHIDCNSUT,NI,CMANCENORLDVOIENB,,ULAPARISTCTULUIYMTM,APRHYNENSGOELDNAEPN,EDR:TTHGY.MUYS:EH SPTEHENYATRRNOIAI/LDLAVGELRSAYINNCDRL,,ESP,EAYREUA(RTSIH)NYARWROIYITDBHLGAOLDPADNTEDIRSC,, NETTRERVSASTC,EHSE,RS:KIENPE,ISDOIPBDHRYAOMGSIUTDSAS,VSE,, FEMUR/KNEE JOINT, STERN, NOSE niscepathology ~ savesFIANTFTLYAGCIHTAINOGNE,, MSEUDBIAACNUTCEL/ECFHTO.NImCi,nimmailn.tpal. mHvR0NIEDCRGOLSAINSD, : FOCAL, mintnal. `AUTERAFION, COLLOID, minimal. No MiKIcDrNoEsYcSo,piTe UAbSn,ormNaOlSiEty Observed : -- --- Gompany Sanized. Doss not contain TSCA CI --Sutcrone Toxic Dwromsi7s --~ Showing anIinmdailvidduaatls afnoirmailndLiviisateienlg annals SsoomoetS(up6: 5TD1mg/nktg/sday Sex: Wales aimed ret Wicroscopic & Macreseapie Findings Sito SKTeieplrolmseiudnraeol.nGsrbaoecurypi.f+i:c1eR83ECOV Aen Sa Sioned off From necropsy Gross Pathotosy : No MAaICcoKrEnoRs,,copKBRiIAcDINNEA,YbSm,SoPmILaONlNAiGLSc)CyORWODEb,sAeNSr,vOeMSdMKCEHL,ETADLUMUDSCELE,JSSPTLOEaRN,, NNTOLO5EEGR,u,ESHEGLNTCoVRAsERA,YS,GLSACCNRIDCASOT,MI,CWNACEONRLDVOIENB,.STAFRRERTCURLRUYTNMA,PRHY.MEMCOSBELSNA,FDE:RREEG LL,yre FSTSEAHEANYRTNRO/,SuEVGASELRSAINIOCDKTL,,ENSP,,BAYRBSUK(TRT8ID)ENIRRAIOYINTDHBLHGAoOLDBPADsNIEDZRSC,, NETTR3RVGAEPC,SESR,S,KSIPRNIBDSIPPDERUAORGGELRDSRA,ESE,, ~ sistopatholoy : Lave + TReROEE"DN,rILGEaLYAnNCrDHiANo+GNE,, MSEUDEIAACNUTEC/LSCFHTR,ONIaCi,hinmailn.inal. ADTERARION, COLLOID, mild. #0 Hiogwzoessse,ptmeisnhsmo,mmNaOlSiEny Ghaerved : ~ - on CompanySantize. Doosnot contTSaCAiGBn I XDiD OralGyavageoSu :inyRelToxicoity mgSotyinkDouwe reomno0s4s7s8 --_ soe QoS/heoawleing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg aninals Dose Group INE 0 ng/ka/asy Sex: Males Sminal not Microscopic & Wacroeopic Findings Grits TEKexirplmolnieundraelonGsrbeoecuyrpit1i+ c1Re8ECOV inal 5 signed of from necropsy Gross pathology + No MAaLOIcRVrTEoARs,,copBKiIRDcANTEA,YmSo,SmPLaIONlNAiGLtS)yCORWODbE,sReTSr,TvOeMSdAKCE:HL,ETADLUOMDUESNCGLH:E, TSHrpeEre,n ANIOLDEDEU,MR, SAPGLALNIACVNRADERSAY,S,GSLCACNICDNUSTM,I,CMNACEONRLDVOIENB,,ULAPRRETCOTLUYIMAE,RSYMENSGOEDLNEAP.NEDR,MSSA.ILLoubH SSTTHEHYAIRRNOOAILD VTGEALSRAIYDCN,L,ESS,EAYR3GA(RTSAC)YARRWOYITTDBHLGALODAPDNTEDIRSC,,NETTRRRVSAETC,EKSE,RS,kiSnBH:SDOIPSARSAoTGGIUEASSR,RES, FRE JOIN, STERN, HOSE --~ sstopathotony : savesNhEeCRuOSoIIS,onFO,CALs,uAmciod:Ts/Coue, mia. J.CHHEREORNSICLAPSRTO,GREBSISLIEVEDUCNEE,PHRmOiPnAiTmHaYl,. minimal. THERONTCDRBGRALTION, COLLOID, mininal. No MiTcirnoossc,opNicosAbnormality Observed ~ e------En-- emai------ ------e-- es. CompanySanitized. Dossnot contain TSCA GBI icToxicity DDuyOOrnalOvGeavapgsStudyiinkRaetss DDuuePownts.9a47n8 ~~ Showing anIinndailvidduaatla AfnoirmailndLiviisdtuianlg animals sDtousepyGr:oCup2+1190 1mg/mkag/eday Sex: Males Animal Ref Microscopic & Macroscopic Findings 654519 XTielrlmiendalonSDaacyrif: ic17e5 AEnxipmoaslureisGrsoiugpned: SofAfTELfrom necropsy Gross rathology Ho MaLIcVrEoRs,coKpIiDcNEAYbSm,omLaUlNGiSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAN,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSOEHN,TERJIECUNLGYHM,PH NAODDREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITULIYTMAPHRYNOGDLEA,ND,THYWS, TPHHAYRRYONIKD/LGALRAYNNDK,, PSAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSERMNIUNRA/LKNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, ~ esas2 KTeirlmliendalon sDaacyrif: ic18e3 AEnxipmoasluriesGrsoigunped: oRfEfCOVfrom necropsy Gross pathology : No MaLIcVrEoRs,coKpIiDcNEAYbSn,omLaUlNiGSt,y HOEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAN,, BPARNACIRNE,ASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYMUS, 654524 Continued on the next page .... -_-- 701 `CompanySanitized. Does notcontainTSCA CBI O EEc N ity P POOR.F .. ----v-- c SO sSorroeoeo Qedemataey so ates Dupo oa comtimaed Econ previous pore E ee eT n ee eA o- nst aos, Ty eac, so, mos, a ii gis c fn Rlsm [---- Lavan ES cA --_ ------ Tr eE ee rom nuctopey aeons satholony wo R rgEg SALIf ) WORE RI in ns, HomieaareeaMeormtanmoapn,i,toe 054525 Conpinsed on mae wens sea _ _--_-- CompanySais. Does ntcontain TSCAOB! C 90-DayO OralGavS age Study, inRats Tonicity Dupont9478 -- Showing anIinndailvidduaatla AfnoirnailndLiivsitdiunagl animals sDotsoevyGrgoRuJp:461901/mgn/akgl/eday Sex: Males Animal Ref Microscopic & Macroscopic Findings 650925 Continued from previous page Gross pathology No MaTcHrYoRsOcIoDpGiLcANADb,norPmAaRlATiHtYyROObIsDerGvLAeNdDS:, TRACHEA, ESOPHAGUS, SPEHMAIRNYANKL/LVAERSYINCXLE,S,EYEU(RSI)NAWRIYTHSLAODPDTEIRC, NTEERVSET,ES,SKIBNP,IDIPDRVONSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE Histopathology LrvemIN:FLAMMATION, SUBACUTE/CHRONIC, minimal. PITUIoTATRYpRGELSAENNDT.+ EYE(S)OPTWIICTHNEORPVTEICNONETRVPERES:ENT. ~~ No MiKcIrDNoEsYcSo,picLUNAGbSn,orHmEaAlRiTt,y OSbKsEeLrEvTeAdL M: USCLE, SELEEN, AORTA, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PHINLOEDVEH,, GSLAALNIDVSA,RYSCGLIAANTDISC, NMERAVNED,ISTUHLYARROILDYVGPLHANNDO,DE,EATRHMYTMHUYSR,OIADDRGLEANNADLS, TEYREA(CSH)EA,WITEHSOPOHPATGIUCS,NERPVHEA,RYNSKK/INL,ARYPXRXO,STATE, SEMINAL VESICLES, USTREIRNNAURMY, BLBAODNDEERM,ARRTOEWS,TESN,OSEEPIDIDYNIDES, FEMUR/KNSE JOINT, -- -- -- `Company Sanitized. Doesnotcontain TSCA CBI Cs O20MDayOro alGavage s 0 inFas; --_ Shoving anIinmdailvidduaacla AfnoirmailndLiviisdteianlg antrals DsotvoeveGQREOEUR)Tas0 om/mvagt/easy Sex: Males rina et Wieroseopie & Macroscopie Findings Duronsi7s nEKxiiplaolseludreTosnGrsboieugynpe:d+ 1o8Rf3EfCOVfrom necropsy Gross pathology + No MHaoOcvRreTonAs,,copKSRiIADcTNNEA,YbSm,`oSmPTaIONlNAiGLSc)yCORONDbE,sAeRSr,vTeOdSMKAECLHSTADLUODMEUYSOCNL,E, TSEPSLOENENN,, RNLOOEDREECE,HH,ASLAPGLALINACVNRADERSAY,S,GLSACCNBIDCNSUT,MI,CMNACEONRLDVOIENB,,ULPRASLRCTRLUUYLNIM,APRHYNNEOGSDELEVA,RDE,TRZCHL,iNEH STFEHIMUAIRRNOIAINGLD/LVGALBRASINIDNC,KLE,S`,EPYABOR(VA3IT)NIARWROIYTTDHBLGAOLDPADTNEIDRCS, NTETERRVSAETC,EKSE,RS,KISNPE,ISDOIPPDHRYAOMGSUIASDF,EES,. TERRES Som, SPER, HORE ~ Histopathology : LavenNI;ENCPRLOASGINST,IOFNO,OALS,UBmAiCnUiTmEa/lC.HRONIC, minimal. INPERPLAGIA, BILE DUCT, mininal. HEROTACDLHRTGORLNAAIINCLD.OPNR,OGCROELSLSOIIVDE, NEmPoHdeRrOaPtAeT.HY, mininal. No Mi"cmroossc,opNiocsEAbnormality Observed ~ e ---- rence: CompanySantzed. Does notcontTSaCAiCBnI C 90-DayO OralGavM ageStodyM inRts . Toxicity Dupont9475 -- Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg aninsls sDtooseyGrCoump):1ic0sm1g/mkaai/day Sex: Males Animal Ref 654520 Microscopic & Macroscopic Findings KTeirlmliendalon SDaacyrif: ic93e AEnxipmoaslureisGrsoiugpned: oSfOfDAYfrom necropsy Gross Patholosy Yo MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPmLTUaNNlAGiLSt,CyORHODEb,AsReTSr,TvOeMSdAKCEHL,ETDAULODMEUNSUCML,E,JESJPULNEUSMN,, ANIDOLDREEEU,MN,ALSAPGALLNIACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CNNACEONRLDVOIENS,,ULAPRREICTTULUIYMTW,APHRMYENOSGDLEEAN,NTDE,RTIHYCMULSY.MPH STPEHHMYAIRRNYOAIIKLD/LGVALERASYNIDNC,KLE,SP,SAYRBUA(RTSIH)NYARRWOYIITDBHLGAOLDPADNTEDIRSC,, NTETERRSVATECE,HSE,AS,KIENPS,ISDOIPPDRHYOAMSGITSDA,ETSE,, FRMUR/XNEE JOINT, STERNUM, NOSE Histopaptahotlhooglyogy : LaverINFLMOITION, SUBACUTE/CHRONIC, minimal. KIpuECYHSRO+ NIC PROGRESSIVE NEPHROPATHY, minimal nearCA:RDIOMYOPATHY, mininal. PANCREATARSOPHY, minimal THYROAILDTEGRLAATNIDON+, COLLOID, minimal. 5S(5)OPTWIICTHNEORPVTEICNONTERVPERES|ENT. 65492 Continued on the next page -... --_ > Ee Company Sanizad. Does no contain TSCA Cal C 500s) OnO lGavagsSt: y nRas. vcs Dsus --~ srove Q24co1Smhaorweing anTiustev)idoagcha JfortindiSviiabenegl animals Dose Grow L 0ngvasaay sex: ates emp ieroncopis & Taccomcopts Findings Fen Com ieed trom previous pede stwssmvoi + encoTrReRL+ASTION, SUBACUTE/CHROVIC, mintel. rore aane nLyS,ea-- SnoLEETre,aO,RTCH,BRERALSNO,LSEPIANR,TOCO,ND, fr DE Rg R ratR een" ed fficrB igh RgoR eaeI a straJ ssasns reenoinn) sapceerit1i5c3e ~ free Exposure Group : 90DAY [EP No Nmaocnrno,scoBEptiacmaeAnbnneoSrrTmaalmoitoyrSObnosaevrSeviedoSCuEnLETDALioWInSeCL:E,SSPaLEE,N, E Eprres Mg Rg s iget Soni 654525 Continued on the next page +... _-- CompanySanizsd. Doe otcontain TSCA GBI prey SusRtvaoic Tovey Duron ous -- sooy (QEYs61mShaotveing aInnndai)vidduaacla AfnoirmailndiLviisbteiansg anipals Dove Group IVE 0 2gkgday Sex: Hales Raina ret Microscopie & Wacroreopis Findings Sivas Comino Fron previo Seon Gross Pathology + No MaFRcEOrAIoRsSc,opCiGAcLRAINAIDbE,m,oPEmAaVRlEKi(R3tI)yIRWOOIbTTsDHerGOvLPAeNTdDISC:, NETRRVAEC,HEAS,KIXE,SOPPHRAOGSUOASV,E, SFEaRa/lREVSESISCOLETS,, CSATNEARRNY, BOLABDEDER, TESTES. EPIDIDOSES, stopacholony : LavenEF:ATATLTaYmACnHAINoGnE,, BMEODOIAMNSC!LECFHTR,CNTmEi,nipmailn.inal AETSRARRON, COLLOTD, minimal. ~ No MiEKEcRorANoNEs,vcSo,pGiPcLINAACbSn,CoOrRHmDEa,AlRiTSt,yTOOSMbKAsECLeHErTvDAeLdOOWDUESNCOLNE, JSEPLREREN,, ALORRTA,, GSELANALNCIDVESA,SRY,SGCLICANBNTDNESC,, NENCRAoVNrEDo,ItS,UPLIRRBTRCO.FIUTLRAX,REYRNEGLSNAORNDYDEE,.RLGTP.AARILNNTISH,NYERAODTNRODDEEGN,LAALNDS. UTEYRRBAI(CN8KA)E.RRY,WIBLTEAHSDODPOEHPRAI,GYUCST,ENSETRPEVHSEA,,R ESKPIILND,IADRIFNDRIO,DSRTSA,TE,FEMSIERN/IRNNAELEVESSOIDCL,ES, SER, BONE waROn, Nos ~ eer ee eee e nt Gompany Saniized Does not comain TSCA CBI C90-- DayOral CavageStyinRaxtscToxicity DuPont9478 --~ Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals DsotsoeovGrJoiugpl)1>%e609m1g//mkagt/eday Sex: Males Animal Ref Microscopic & Macroscopic Findings 654936 KTielrlneidnaolnSDaacyrif: ic9e nExipnoasluriesGrsiogunped: oSf0fDAYfrom necropsy Gross Pathology : TesTEDSISCOLORATION, OPAQUE. No MAaLOIcRVrTEoARs,,copBKiRIADcINNEA,YbSn,SoPrLImUNaNAlGLiSt,CyOROHDbE,sAeRrS,vTOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANIDOLDREEEU,NM,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULAPRREICTTLUUYIMNT,PAHRYMNEGOSLDEEAN,NTDE,RTHIYCMULSv,MPH STPEHAAMYRIRYNOIAINLDK/VGLELASARINYCDN,LKE,S`,SPYAERU(ARSTI)HNYARWROIYITDHBLGALODAPDNTEDIRSC,, NEETRRPVAIECD,HIEDRSW,KIIDNEE,SSO,PPHRFAOGSEUTMASUT,RE/,KNER -- Jomwr, STERNUM, Nose Histopathology sLEIRVREYRI:NFLAMMATION, SUBACUTE/CHRONIC, minimal. estesCARDIOMYOPATHY, minimal. 'sDeEvGeErNeE.RATION/ATROPHY, SEMINIFEROUS TUBULES, BILATERAL, 650936 EpIDIODLYIMGIODSEPSERNTA/GERN CELL Continued on the next page ... DEBRIS, BILATERAL, severe. -- _-- 06Company Sanitized. Does not contain TSCA C81 Oc---- Duron es ~ sour QEass1Smhaotvsing mIinndailvidduaacle afnorimanldiLviissteiensg annals Some GroUP OIE 0 g/kg ay sex: ales minal ret Wioreseerie & Wavroseepie Findings re Garcia From previous pore Bistopatholony + No NCiSocuParEoRcYsLceo,pCCtoOtReToDIn,NN,GmSSo,RHrSOmCSAaTKGiOEHNiL,,tETyDNAEOLOSbEsNONOeSTrDCSvL,ReEId,CJ:DBSSPIULMNEEGEHN,,ODATEOL,RETGAHS,,ALIASVRAAcTRNYh, . ESCEAoTRmNAmDTsSH,GNRNYOARTNEDGL,LBAUNLPDAISRR,ULISTRAiARCYHELNAOA,DNS,B,SOODIASAYGRU,OST,DAGOPRLHEAAIDRA,TLG/GLLAANDRS,, oUERVsRIx(N5A)RYWBELTADDOEPRT,ICFEKENROVRE/.ANESSKEJ,OINPTR,OSTSATTEE,RNS.EVBIONNNEL VaEnSoIEnL:SS, 65493 EKTxoipmomlsieunraedonGsrDaoacuyrpi1fi+ c1Se75ATEL ~ aa 1s inmed off from necropey Gross pacholony o MHaEOcvXriTonAs,,copSFiIaocnNRA,YbSn,SoPrILmNaOAlGLiSt)CyORWODEb,AsNeTSr,TvOeMdSAKCE+HL,ETADLUCDWEINSOCNL,E,JSEPLNENEN,, THNTOHOiDNSRmR,OE,T,SSAPGGLaLLnIAAcVNNRADDiR,SAY,S.GPLSAACCRNIBKDATSCTI,E,RCOMLNAoEDNoRDVnGIELS,,AVNLDPARSIRE,TRYUUTIHNRTP:AAHCRKYNENEROGS,DLEEAN,NFBDSE,OARPZAHCVAGELUY,SH,PH SSEEANRTEAALRCmVsAERSIISCoNLm,EeS,,EYTSERE(T)RNCARWHYI,THB1LA0OD6PD3TEIRC, NETREVSET,ES.SKSIPNIDPIROOWSITDASTSE,. ~ -------------- tetera [I ------ COWbyYOe n sc Gmptmat opwiee ann --_ sS tor (ReC ss PnaOteNE. ...op- og tes i SO Sepeee: nSnEO TE saceeper A TE Ra oL dustsr , t. insOE aI rryaoeyiIt,l Se ira "Tove.iat, mostly. ~ -- rvireneiacon, aris oun, minioat. ml oE ikEramcgosnteolrsp, ravage sinieat. Pisin. dereecenicA - eereeem------pees CompanySwitz, Doesecon SGAEY XDyYRO gEhdwin O Rats ivegedudyinkDDuua opomno9s 478 PN Showing anIinmdailviddautaal AfnoirmailndiLviisdtuianlg animals DsotsoenyGr_o-u(pgl+)12ss09m1g//mkagl/eday Sex: Wales Animal Ref Microscopic & Macroscopic Findings 656945 AEDexucprioadsteuironencaGlorlfoyudpoKsiilnlgeR-EddCaOyVs: 163 Animal is signed off from necropsy Gross Pathology : Yo MALaOIcRVrTEoARs,,copBKRiIADcINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,RSIPLUEMEN,, ANTDOUDRSEEU,NN,A|LSAPGLALINACVNRADERSAY,S,GLSACCNIEDCNSUT,NI,CMANCENORLDVOIENS,,ULPARIRECTTULUIYMTM,APRHYMENOSGDLEEAN,NTDE.TRIHCUSLo,wbH STPEHHNYAIRRNVOAIINLD/LVGAELRSAYINICDKL,,ESP,EAYREUA(RTSIH)NYARWROIYITDBHLGALODAPDNTEDIRSC,. NETTRERVSAETC,EKSE,RS,KISNeE,iSDOIPPDHRVAONGSMUTISAD,TEES,, FENUR/XNES JOINT, STERNUM, NOSE Histopathology ? LavemHIYNPLEARVPMLAATSIIOAN,, BISLUESACDUUCTTE,/CHmRiOnNiImCa,l. minimal. xxougCyHsRONIC PROGRESSIVE NEPHROPATHY, minimal. Yo MiTcHrMoUsSc,opiTcAYRAObToDmmGaLlAiNDt,y NOObSsEerved : --_ _-- ETE Company Sanitized. Does not contain TSCA GBll (90.-- DayOralGavageSudy inRats Toxicity Dupont9478 -- Showing anIinmdailvidduaatla AfnorimailndiLviisdtuianlg animals DsoTsoepyGr(oupc: 1o0:mg/rkag/eday Sex: Males Animal Ref Microscopic & Macroscopic Findings Gs4550 KTeirlmliendalon SaDcayrif: ic93e AEnxipmoaslureisGrsoiugnped oSf0fDAYfrom necropsy Gross Pathology : Yo MAaLOIcRVrTEoARs,,copBKRiIADcDNNEA,YbSn,SoPmILaNUlANiGLSt,CyORHODEb,AsReTSr,TvOeMSdAKCEHL,ETADULODMEUNSGCHLNE,, JESIPULNEGEMN,, ANIDOLDREEUE,MN,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMANCENORLDVOIENB,,ULAPRREICTFLUUYIMMT,PAHRMYENGOSDLEEAN,NTDE,RTIHCUSLY,MPH SPTEHHMYAIRRNOYAIILD/LVGAELRSAYINNCDKL,,ESP,SAYRBUA(RTSIH)NYARWROIYITDBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPS,ISDOIBPDRHWOAMSGITSDA,ERSE,, FENUR/KNER JOINT, STERNUM, NOSE _ Histopathology : LrvemINFLAMMATION, KIDNEYS SUBACUTE/CHRONIC, minimal. HearCHRONIC PROGRESSIVE NEPHROPATHY, minimal. PARNTCHAYRRDOIIODNYGOLPAANTDHSY,| minimal. 2YB(5)YoWrITRRESOEPTTI.C NERVE estesFOL: D/ROSETTE, RETINAL, minimal. 654550 Continued onmDiEtnhGieEnNanEleR.xAtTIpONa/gAeTR-O.P..HY, SEMINIFEROUS TUBULES, BILATERAL, ~~ _-- Te `CompanySaritized. DossnotconTtSaCAiGnBI O 500s OR nl GaD uge. ns 1s: Dupes _ Showing anIinmdeilviddueacla mfoirnailndLiviisdteien)g anisals sor (Reiss nals frm Dose Group :1 0 mg/kg/day Nicraseoris &SexW:acrMoarleeospis Findings pe Continaad Even previows pore Histopathotony + to MiSLicmrnooss,coopSiRDcEULAEGTbBRmEGoNNmW,aOiSiCSLtEEy,SObS,sIeLrEvTReL,dEO.:VEFRR,ICRBERRADD,N, CSoPtoInNACocrootns,, ESieIn Oos,GTtRSH,OALDORGaLAGD,La TAACBAKSSSEoMmEmReE, HFEiLanSaOAnN,RoEoDh,TDIoISKOIRNS,, FFROOGMEOARTISC,IERSeSiOnLe, VSeesestvsen,, mSaany osass rKEeriremlriaenraelonGsrpaeocrurpii:c5a33008Y nat Te sium off from necropey yn Gross Pathology : o MHaLoicnvrmaoans,,coESpIiaDcaNmEAiYbSm,SoemTraIilNiGaSc,yCoOJtEb,AsReTSr,TvOeASdAKGE:HL:ETDAHLODwEsRcTLHeL, IsSeOuN,, STTLoIEObRaERO,,LEDSEGGATNiaCAnbRoER,sA,S,CPSALCCRITsBNRUD,II,RCOWTMCA,OELRSOGENLS,,AENDPRRSEr,CrTviOArRaG,RHaWYAREgo.OneTnn,EEiSRooSEPSHAeGLLSi, FSfeomynitnRCVAEgSRIICC L,ES,BYDe ESA) YHIe TapObPeERnC. NTERRSS:ES,SKIEnS,iDEPSAVMGEEDRSL,. 65435 Continued on the next page se r e------En---- sm-- b --e Company Saniizad, Boss not contain TSCACEI O 3X0DaDyOraR yGOove n) inlRaiCc TioyvugsSudyinukDourwoens9es07n8 --_ Individual Aninal Listing DsooseoG(RYO2TcTsOsna/Smkhaao/seaianyg animal daca for Sex: Wales Sndivideal animals Satna ot Microscopic & Macroscopic Findings pre Gonvinand From previous peg Histopathology KavoeosnNsP L+AGATION, SUBACUTE/CHRONIC, mininal woesICNRFRLOANOIIGNTPIROONG,RESSUSSIAVCEUTNEE/PCHHRROOPNAITCH,Y, mimniinmiamla.l. osnmicnaEr RS ; r -- PrruIvSTSAsRRtoY,PHGYmL,iAnDimmianli.nal. BeRroiSsT)AOTTWEIiC+iNEoRPVTEECNNOETRVPERES:ENT. ~ INFLATION, SUBACUTE/CHRONIC, minisal. No MiSScTKrOEMoLAsECcTHoA,LpiDMcUUSAOCmDLoEEm,Na,SlPiLJcEEEyNN,ONbAs,OeRrTIvALe,EdUMS,AICNB,EUNS,PCROLLONC,ORDR,ECT, HENoEAbSRsER,NITEYTRRIHOCUI.DSL,GYLMAAPNDHDRSOE,NDAETL,RAGCLSKAAELNRID,VSAERSYSCOIGPLNHATANIGDCUSS,NERPAVRDEAI,RBITUNIR/AOLRLARSLAOGWIEAND, SRSYoAEvD(eD5E)vRa,kWsIoTHTE,STOEHPSo,CsBPNIERDVTED,RIISDKRAS,, SSEENUTRN/ALKEVEESIJCOLIENST., USRTDAGRANRNY, _ --_-- Company Sanitized. Does not contain TSCA Cal Dayo suncvaonsic Toit Dupes - sro QE csi mShaotweing anIinadailvidduaarla afnoirnailndLieiisdteisntg aninals Dose Group Y 0 po/vo/any Sex: ales minal net Wicroseopic & Meoreseepie Findings pr EKTreiprlomlsieendraelonGsbarecorywif+ i+ c1eR83ECOV Reload Sa Sioned off From necxepey Gross vatholosy + No MTaLicovxmeons,,coBpRiRIcADENAY:bSn,oSrPLImUNaNAlGLiSt:CyoNOnEb,AsReTSr,vRedNSKRE::LETDAILoDNRURSOCHL:E,ISSeLOEm,v, RNTOoLDREEE,i,ndSHECALRTLCVRASERA,YS,GSLCACNIBDCNSOT,MI,CJONCEONRLDVOIENB,.OLBARIRERRGFUTTNAH,RYN.ERSGoELbNA.FDE!ARLACREL,oni EFSTEEEERMTRIORAET/eVGARELRSAINJICDo,L,EmS,E,BARYSUAETRRSARS)YRNRCRWOHYIL,TDHBHLGoALODASPDN%TEDIRSC,, NETTRERVSAETC,EHSE.RS,KISNEE,ISDCIPPDRRVAOMGGIUIDSRR,ISE,, Histopathology : ~ eLavsanoIieGLIADTIO+N, SURACUTE/CHRONIC, nininal. fire ------ No MiCcorvoesrcso,picHASbm,omaRloiscsy Observed : ~ ------------Er------------ GompanySaiz. Dossnocontin TSCA Col C N DayD OY n y C) ovo ag: ienRw Ways O itygSedyinkDoe uwroenss 5s47s8 ~ Showing anIinndailvidduaatla AfnoirnailndLiivsitdienag animals DsooseeGrQ ou PE c0 2g/mkgs/any sex: Males Satna rot Microscopic & acroseopic Findings Gases eKExirplmolisenudarleonGsrbaoactyrpif: i:c1Se75NTEL nial io signed off from necxopsy Gross Pachotogy o Ma`HLOcIRrVToiAsR,,copKBiRIADcINNEA,YbSm,oSrPmILOaNNAlGLiSt)CyORoWDbE,sReTSr,vTeOdSMKAE:CLHETDALOMOUSDCL,E, TSBPyLtERENN,, NAIODLDEREUE,MS,,SAPGLALINACVNRADERSAY,S,GLSACCNBIDOASUT,NI,CMNACENODRLIVOBENU,,LAPRREI.CTTUYUIIMTP,AHRMYENOSGDLEEAM,NFDE,mRLCAL,ub TESERRMYIRANOANDL/VGLBLASARINICDNL,,ESP,EAYREUN(RT5IA)NVARRWOYEIRDHBLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,RS,KISNPE,ASODRPIERDAOMGSIUTDASET,SE,, SENKEE OTN, STERN, HOSE ~ ssisn TKEexirplmolinenidarleonGSSraaocyurpif: i+ c1e7S5ATEL inal a signed off from necropsy Gross Pachotogy o MaIHOcVRrEToRAs,,copKBiIADcINNEA,YbSm,SoPrIDmONaNAlGLiSt,CyORWODbE,sNeTSr,TvOeWSdAKCE:HL:ETDAULODMEUNSOCML,E, TSeesetm., NNTOOEDRENE,R,ALSAPGLRLINAVCNRADERSAY,S,GLSACCNRIDCASUT,MI,CMNACENODRLIVOBENU,,LAPRRRE.TCTOTUTYMII,APHRNYENSOGEOLNRAP,DER,TIAC.HILRY,WPH 654971 Continued on the next page .... : --_ --m--es------------tereeegeeepSmammeeti Gompany Santze. Donotscontsain TSCA Cl -- VAIO isnctRraonsic Toxicity Duron 9478 --~ Showing anIinmdailvidduaatla afnoirmailndiLviisdtoiansg animals DsotseoGrQ ay NT 0s na/kg/day Sex: Hales Sainal nf Microscopic & Macroscopic Findings sist Continued from previous page Gross Pathology Yo MaPTcHHArRRoOYsTIcDCoUp/GiLLcAARNAYDb,Nm,orFEmAYaRElA(iTStI)yROWOLIbDTsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, PSEEUUINN/NKLNEVRESIJCOLIENS,, USTREIRNNAURMY, BNLOADSDEER, TESTES, SPIDIDRMISES, sss EKTxeiprlomisieunaraelonGsrabcoaruyip:f:ic55eS0DAY Animal is signed off from necropsy Gross Pacholony -- o MAaLOIcRVrTEoARs.,copBKRiIADcINNEA,YbSn,oSrPLmIIaNNAlGLiSt,CyOROHDbE,sAeRrS,vTOeWSdAKCE:HL,ETDAULODMEUNSGCHL,E,JSEPLSEUEN,, AHIOLODEEUR,M,,SAPLGALINAVCNRADERSAY,S,GLSACCNICDAUSTM,I,CMANCEONRLDVOIENB,,ULAPRRIETCULITYTM,APRHYNENOSGDLEEAN,NFDE,RTIHCVHLS,ak EESTAEHRMNYIRINOOATNLD CVGAELSARINICDL,,ESPB,AYREUART(I9I)NNARRWOYIITDHBLGALODAPDNTEDIRSC,, NETTRERVSAETC,EKSE,RS,KISNPE:ISDOIPFDHRWAOMGSIUPDSRE,ISE,, PRMUR/XNER JOINT, STERN, HOSE Histopathology : LavenP`ArTLTeYaCTHIANoGNE,, MSEUDRIMACNUTSC/LECFHTR,ONImCi,nimmailn.imal. 634572 Continued on' the next page. ~ ee -- e------ET-- A -- ees -- ---- e Company Sanitzsd. Donotscontsain TSCA CI S Day Oral Gavac ge Study in RatsToxicity Duone9478 --~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals DsotsoeoyGrouRp:Ya069m1g/mkagl/eday Sex: Males Animal Ref Microscopic & Macroscopic Findings 654972 Continued from previous page Histopathology : KIDNEYCSHRONIC PROGRESSIVE NEPHROPATHY, minimal. BYE(S)ADHWEISTIHONO,PTRIECTINNEARLV,E m:inimal. Yo MiCLOcURNrDGo,Ss,coSHpTEOiAMcRATCA,Hb,noSrKDUmEOaLDlEEiTNtAUyLM,MOUbSJsCEeLJrEUv,NeUdMS,P:LEIELNE,UM,AORPTAAN,CREBARSA,IN,CECSUPNI,NAL MNCEAORLNVODENI,,BULPRAEIRCTTUULIMTY,AMRPYMHENGSLOEADNNETD,E,RTIHTCYHNYLURYSOM,IPDHADNGLORADENEND,A,LSASGLLAAIRNAVDTASHR,YYROGSILCADINADGTSLI,ACNDS, VTERSAICCHLEAE,S, EUSROIPHNAAGRUYS,BLAPDHDAERRY,NK/TLESATREYSN,X,EPSIKDINI,DYMPIRDOESST,ATEF,AMUSRE/MRINNEAEL JOINT, STERNUM, BONE NARROW, NOSE ~~ esiser KTielrlmiendalonSDaacyrific9e mExipnoaslureisGrsoiugpned: o9f0fDAYfrom necropsy Gross pathology : No MAaLOIcRVrTEoARs,,copKBRiIAcDINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E,JESSPULNEUEMN,, ANIDOLDREEEU,MN,ALSAPGLALNTACVNRADERSRY,S,GLSACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULRPAEIRCTTULUIYMTM,APRHYWENOSGDLEEAN,NTDE,TRHIYCWULSY,MPH 654587 Continued on the next page -. _--m Ee `Company Sanitized. Does not contain TSCA CBI Ocie. 11 po --_ OM. .n.cv.iidpivai ssogiea5t Li1sting tov (ccmo ete Gn Te ---- J SE preei RowesaiiE n (na at 1 mau,ahsama ER i eversion. ssa: tithes, TI a Necesnairarinn --- L a A T Int eTeLn,Lhs,onT. aTmtaIse.t.. FpA aL ano a on nT eineeeeeeeeiemeereem-- CompanySaiz, oss contiTSCAG1 -- CDayO OraGS avageS. ay nR. as . icy Duper 478 P stor (Q691D mSehorweing anIinmdailvidduaatla afnoirmailndLiviisstuiansg animals Dose Group + 1 0 na/ko/day Sex: Males Aminal ne Microscopic & Macroscopic Findings ise ETKxeiprlomlsieundraelonGSrDaoacuyrpif1 i+ c16Re3ECOV Aninal is signed off from necropsy Gross Faholosy : No MAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,SoPrImLNOaNAlGLiSt,CyORRODEb,AsReTSr)TvOeMSdAKCE:HL,ETADLUODNEUNSUCML,E,JSsse0uemmE,, ANIDOLDREEUE,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNIHDCNSUT,MI,CMNAGEONRLDVOIENB,,ULAPRREICTFLUOYIMNT,FAHRYMNEoGSBEhhNa.FiE.NRTSLL,er TESHHEYARRTOYINADG/VGLELASARINYCDNL,,ESPE,AYRUA(TR9H)IYRAWOYIITDBHLGALODAFONFEDIRSC,, NETTRERVSAETC,EHSE,AS.kiEnBR.SMPDPHYRADOGISUOISRT,GE,, PEMUR/KNES JOINT, STERNUM, NOSE --_ Histopathology LovenFIENEERLTMIRATSIIOAN,, BISLUSEACDUUCTTS./CHmROiNnICa, mingnal. KooCyHRONIC ZROGRESSIVE NEPHROPATHY, minnal No Mi"cHriossc,opTiHcYRAbOnIoDrGmLaAlNiDt,y NOobssherved : --~ reeoms eeee ------i ---- Company Santas. Doss not contain TSCA BI A 50 D0DyayOOruall) CegCaveagdeOitdyyiinnRRasis: 5:1; DDuuopomnto9u47n8 ~ Showing anIinrdailvidduaatla AfnoirmailndLiivsitduianlg animals DsoosneyGroup "1 o0 omg//ekagi/eday Sex: Males Animal Ref Microscopic & Macroscopic Findings 54993 KTielrlmeindalon SDaacyrif: ic93e AEnxipmoaslureisGsriogunped: o9f0fDAYfrom necropsy Gross pathology : No MALaOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,SoPmILaNUlANiGLSt,CyORHODEb,AsReTSr,TvOeWdSAKCE:HL,ETDAULODWEUNSUCML,E, JESTPULNEGEMN,, ANIODLDEREUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCNSUT,NA,CMNACEONRLDVOIENB,,ULAPRREICTTLUUIPMT,AHRYVNEOGSDLEEAN,NFDE,RTIECMSL,AE STBEHHMYAIRRNOYAIILD/LVGELASARINYCDKL,,ESP,EAYREUA(RTSIH)NYARROWYIIDTBHLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,LSDOIPSDHRYAONGSIUTDSAE.TSE,, FEMUR/K0ES JOINT, STERNON, NOSE Histopathology : KLIaovNeEnYISNFL: ANATION, SUBACUTE/CHRONIC, minimal. sRoSTICANHTFRELOAN| MIMCATEIROONG,RESSUSSIAVCEUTNEE/PCHHRROOPNAITCH,Y, mimniinmiamla.l. No MCiLOUcRNrDGo,Ss,co'SpHTEiOAcURATCA,Hb,noSrKDUEmOLaDElETiNAtULyM,MOUbSJsCBeLrIEvU,eNdNS,P:LELEEN,N,AORPTAAN,CREBARSA,IN,CoScPI,NAL NMCEOARLNVODSNI,,BUPL`RIAETRCUTLIUYTM,UAPRHYMEGNSOLEDANENT,DE,RTIHTCYHNYLURYSOM,IPDHADGNLORADENEND,A,LSPGALALARINAVDTASHR,YYROGSLLCADINNDTGSLI,ASNDS, 654593 Continued on the next page .-.- -- _-- Hi CompanySanitzed. Doesnot conTtSaCAiCanl -------------------------- COsyOrM alGav} ageSt: yinRats Toxicity DuPon.478 ~ Individual Animal Listing Showing animal data for individual animals sDtoosoey_G(roRup)241609m1g//kmga/ldeay Sex: Males Aninal Ref Microscopic & Macroscopic Findings 654993 Continued from previous page Histopathology : No Mi`TcRrAoCsHcEAo,picESOAPbEnAoGmUaSl,itPyHAORbYsNeEr/vLeAdRY:N, EBYLRA(DSD)ER,WITTEHSTOEPST,ICENPEIRDVIED,YNISDKEISN,, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USRTIERNNAURMY, BONE MARROW, NOSE 654094 TKeirlnliendalon SaDcayrif: ic1e83 AEnxipmoaslureisGrsoiugpned: RofEfCOVfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLOaNlGiSt,y HOEbAsReTr,vedSK:ELETAL MUSCLE, SPLEEN, -- AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND,THYWUS, TPHHYARRYONIID/LGALRAYNNDX,, BEAYRER(TSH)YRWOIITDHGOLPANTDISC,NETRRVAEC,HEAS,KINE,SOPPRAOGSUTSA,TE, FSEEMNUIRN/AKLNVEEESIJCOLIENST,, USRTIERNNAURMY, BNLOADSDEER, TESTES, EPYDIDYNIDES, Histopathology : LavemINFLAMMATION, SUBACUTE/CHRONIC, minimal. 654994 Continued on the mext page -... -- -- -- Company Saritized. Does notconTtSaCAiGBnI O 50.DayOnl R CREPRy in: Rts Toc Duon.9478 --_ Individual Animal Listing stove (sor Smhaolweing animal data for individual animals Dose Group : I 0 mg/kg/day Sex: Males Amina Ref Microscopic & Macroscopic Findings Gass Continued from previous page sistopathology : THYRO"IADLTGELRAANTDION, COLLOID, minimal. Yo MiKIcDrNoEsYcSo,picTHYANbUnSo,maNlOiStEy Observed : 654997 TKeirlmliendalon saDcaryif: ic1e75 AEnxipmoaslureisGrsoiugpne:d oSfAfTELfrom necropsy Gross pathology Yo MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, -- AIOLRETUAM,, PBRAANICNR,EASS,PICNBACLUMG,ORDC,OLOSNT,OMARCEHC,FUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGOLDAEN,D,THYMUS, PTHHAYRRYOIIODK/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMVIUNRA/LKNVEEESIJCOLETS,, SUTREIRNNAURMY, BLNAODSDEER, TESTES, EPIDIDYNIDES, -- me Company Saritizad. Does not contain TSCA CBI O 50.DayOralGac vage SinyRc ts Tosi DuPone9478 --~ Individual Animal Listing sTupy Cn]:ceo1/Smhaoiweing animal data for individual animals Dose Grou AI 1 no/ka/day Sex: Males Ania Raf Microscopic & Macroscopic Findings G5e508 KTeirlmliendalonSDaacyrif:ic1e75 AEnxipnoaslureisGrsoiugnped oSfAfTELfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHEbRsAeTr,vedSKE:LETAL MUSCLE, SPLEEN, AIOLRETCAM., PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT.OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUiM,n NAODDREE,NOL`SAGLLIAVNADRSY, GSLACNIDNST,ICMNAENRDVIEB,ULAPRITLUYINTPAHRYNOGDLEA,D.THYMUS, STSHHHAUYRTRYNOIAIRLD/VGCELASARINYCDN,L,ESPE,AYREUART(I5H)NYARWROIYITDHBGLLAOADPNDTDEISRC,, NTETERRVSAETC,EHSE,AS,KIENPE,ASDOIPEDHRYAOMGSIUTDSAE,LSE,, FEMOR/KEE JOINT, STERN, OSE - ssas08 TKeirlmliendalonSDaacyrif:ic3e3 AEnxipnoaslureisGrsiogunped: oSf0fDAYExon necropsy Gross pathology : saw A+voesca, maa, SIDE. 654508 Continued on the next page . ~ --_-- CompanySanlized. DoesnatcontTSaCAiCBnI ( DayOraR l GavY ayignRevs) i Toxicity Dupo 9478 ~ Individual Aninal Listing sDroroe GroNLI2L465L1amS/haoktwoei/ndgayaninalSedxa:taafloersindividual animals perry Wierossapic & Hacroseopis Findings pre Continued From previews pode Gross Pathology : No MRaLOIcRVrTEohRs,,coBpKRiIADcINNEA,YbSn,oSrELmIaNNAlCLiSt,CyOROWDbE,sAeNSr,TvOeMSdAKCEHL,ETADLUODWEINSGCNL,E, JSEPLTEE,N, ANTOOODREEE,H,ALSAPGALLNIACVNRADERSAY,S,GLSACCNBIDCNSOT,ME,CMANCOENLRDOVINEB,,SLAPRRSICTFLUUNNTY,ARYMREOGSDELEVA,FNEDRTIVC SL,EH VFTEEHSAYIRRCIOLNIEGDS,GCLAAURNRIDIN,N,ARPYEARYBK(LTAA)DYDREWORIT,TDHTGELOSAPTNTEDISSC,, NEBTRRPVAIECG,KIEDRPN,RIODSESTSSAO,TPEE,AFGEUSMSEU,ARI/NIAELE or, Shem, oss Histopatholony : ~ KLaevoewnmN:sFL:ABATION, SUBACUTE/CHRONIC, minimal. CARONIC SROGRSSSIVE NEPHROPATHY, minimal. RRSRATION, COLO, mininal. No Miocvro,scoopsisc Abnormality Observed : --_ ---------- ee-- n -- Company Sanized. DossnotconTtSaCAiG8n1 r 90 DayOr Go aveByinr Fe Duron 08 ~ Showing anIinndailvidduaacla Afonri.mailndiLviisdtsianlg antnals DsomveeGr(oupse45a1 1mmasskasday sex: Males rina mt Microscopic & Macrascopte Finaings sions eKExirpimolisenudarleonGsraboceurypi.f1ic33eS00RY aEeal Ta' signed off from necropsy Gross Pathology + LHOERVTEAR. SKIRDDNm E,YS,SPLIINNAGLS)C-- ORMDE,ANTS,TOMSAKCEHL,ETADLUODMEUNSGCHL,E, JSEPLSEUEN,, RNLOOEDREEE,,ALSAPGLALINACVNRADERSAY,S,LSiCCbBICNsUT,NI,CWACNOENLRDOVLNEB,,ULARPREICTFULOIYNTM,APHRNYNEOGSPLEEAN,NED:RTIRCILE:ib PTSHREUAURRNOATLS VGLEALSRAIYNCRDLK,E,SP,EARYUKERTSIR)NVARHROEYIRDABLGALODAPDNTEDIRSC,, NETTRERVSAETC:EKSE.RS,KIENPB,YBDOIPPDRHOOANSGIPSDR,EESE,. FRR ume S007, STERN, OSE --_ Histopathology: Laven: KeoNEE EISNF+LATIOE N, SUBACUp TE/CHR-- ONIC, minisal. THYROATUDTEGRLAAFNLDON, COLLOID, mininal. No Miocsrsoscopic Abnormality Observed ~ -- A -------- TY oe --_ ops T-- T T-- ELLS ro ars stooy QI24691/mate ter, tutes ae a ---- SS openars e OI SonOY ceceepey rose patsy a a Tl -- SE thorns, a mage. , gram SB a LE TE, i a CE haemie, ~ : xvE .neai BRE i surtent. 0 Hfyogteona feeneifty themreat 5 ~ ees _- eeteeoeeeeeemsma CompanySnes, oes ekTSAI (-- 92 0DayD -- Ora y Gavago eStdu:in .RG atsToe sicitv y gedudyinRDpupua onetss 9478 -- Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals sDotsue GrAoupp: :IIiIc311mrgi/keg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings Gsas30 TKeirlmliendalonSDaacyrif: ic8e3 AEnxipmoasluriesGrsoigunped: oSfUfDAYfrom necropsy Gross 7athology : Yo MAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyOROHDEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSOCML,E,JESTPULNEOEMN,, ANIDOLDREEUE,MN,A|LSAPGALLNIACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULRPAEIRCTTULUIYMTW,AHRKYMENOSGDLEEAN,NTDE,RTIHUCMULSY,MPH TPSHEHANYRIRVNOIAICLDU/GVLLEAASRNIYDCN,LKE,SP,SAYRBUA(RTSIH)NYARRWOYIIDTBHLGAOLDPADNTEDIRSC,, NTETERRVSAETC,EHSE,AS,KIENPS,ISDOIPPDHRWAONGSIUTDASET,SE,, FEMUR/KNES JOINT, STERNUM, NOSE Histopathology ~~ LaverI:NFLAGINTION, SUSACUTE/CHRONIC, minimal. THYROAILDTEGRLAATNIDON+, COLLOID, minimal. No MiKIcDrNoEsYcSo,piNcOSAbEnormality Observed : _-- ne CompanySanitized. DocsnotcontTSaCAiCanll C 90.DayOraR l Gavage SY y in Rs: ici Dupont0478 Showing anIinndailvidduaatla AfnoirmailndLiviisdtuianlg animals stupy CR: c5: nae Dose Group : III 1 mg/kg/day Sex: Males aninal Ref Microscopic & Macroscopic Findings rer KTielrlmeidnalon SDaacyrif: ic53e AEnxipmoaslureisGrsoigunped: oSf0fDAYfrom necropsy Gross pathology : Yo MAaLOIcRVrTEoARs,,coKBpRIiADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSGCML,E,JESPJLUENENN,, ANIDOLRDEEEU,MN,A|LSAPGALLNIACVNRADERSAY,S,GSLACCNEIDCMSUT,MI,CNNACENORLDVOIENB,,ULPAREIRCTTULUIYMTW,AFRHYMENGOSLDEAENN,TDE,TRHIYCMULSi,vbH STPEHHMYAIRRNOYAIILD/LVGAELRSAYINNCDKL,,ESP,EAYREUA(RTSIH)NYARWROIYITDSHLGALODAPDNTEDIRSC,, NTETERRVSAETC,EHSE,AS,KISNPS,ISDOIPPDHRYAOMGSIUTDSAE,VSE,, FENOR/XNEE JOINT, STERNUM, NOSE Histopathology : LaverINFLAMMATION, THYROID GLAND + SUSACUTE/CHRONIC, minimal. ALTERATION, COLLOTD, mild. No MiKIcDrNoEsYcSo,picNosAbenormality Observed : -- _-- ER `CompanySanitized. DoesnocontTSaCAiCnBI rm 90-Day OralGav Stua dyig nRaets DuPont-9478 TOON.[ .. ol-- i o-- v:SO sI ro (Bsc mie so tee miner re Reereseopie maceoreapis Fins Gas eSrlmeadlem smerain,e EE Sm mectopey crane sathotony + Ty EED BSEn S0Elivros shiain.it BD SDDE ai i,a inl Soa TEs Sm yeee mon Sanh d a , --~ ssente T Sioranseionpt esacorn icicaoon wasvrees -- J D Ly SeanlSn vSornwoeos: sya EC 50566 contimaed on che ness page... --_ ee sie CompanySanit. oss ot orsTSCA GBI CO9R 0.OraDl GaavaygeSy vinRiatsc Tossy Dupon9478 Pa Individual Anival Listing sro (sesShsowing animal data for individusi animals Dose GioNp REIT 1 mg/ka/day Sex: Males Animal Rot Microscopic & Macroscopic Findings Gass Continued from previous page Gross pathology : Yo Ma"DHcRYArRRoOVsTIcDOo.Np/iGEcLAARNYADNbK,n,orFmEAaYRElA(iTStI)yNRWOOIIbTDsHeGrLvOAePNTdDISC:, NTERRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMMUIRN/AKLNVEESSIJCOLETS,, SUTREIRNNAURMY, BNLOADSDEER, TESTES, EPEDIDYNIDES, ststopatholosy: LKoevoenIeNF:LMGOTION, SURACUTE/CHRONIC, minimal. TROCDHROGNLIACNDP;ROGRESSIVE NEPHROPATHY, minimal. "ALTERATION, COLLOID, minimal. --~ No MiNcorsoescopic Abnormality Observed ssasa7 TKeirlmliendalonSaDcaryific9e AEnxipmoaslureisGrsoiugpned: oSf0fDAYfrom necropsy Gross pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmOaNlGiSt,y OHEbAsReTr,vedSKE: LETAL WUSCLE, SPLEEN, RNTOOoDREETG,AN,, SAPBLRAANIICVNRA,ERAYSS,GPLIACNNEADCLSU,MG,ORNDAC,ONLDOISNBT,UOWLAARCREHC,TLUYMMD,PUHOMDNEEOSNDEMEN,,TERTJIHEYCIMUILNSaM,,ri 54947 Continued on'ADtRheENAneLxtGLpANaDgSe, -S..C.IATIC NERVE, PITUITARY GLAND, -- ar CompanySanizsd. Dossnot conTtSCaAiGBnI O 50 OrY aGa avageS)) ty n Rae: ovicicy Dupont 9478 --_ sro Qn Snhoewing anIinmdailviddautaal afnoirmailndiLviisstuinnsg animals Dose Grp WALL 3 n/ka/day Sex: wales Raina nef Microscopic & Macroscople Findings Ssisar Continued from previous page Gross Pathology Yo MTaPHcHYArRRoYOsIcIEoD/pLiGAcLRAYADNb,Kn,oErEAmYRaEAl(TiSAt)YyRWOOITbTDsHeGrLOvAPeNTdDESC, SENTNAL VESICLES, URINARY BLADDER, NETTRERVSAETC:EHSE.NX,nSeE.iSODPsiHnpAowGcEUueSsL,rEe,, FEMUR/KNES JOINT, STERNOM, OGE Histopathology : KLaavpeneIrNFL+ NGATION, SUBMCUTE/CHRONIC, minimal THYROACILHDTREOGRNLAIATCNIDOZNR+,OGCROELSLSOIIVDE, NEPHROPATHY, minimal. minimal. -- Yo Miocsrsoscopic Abnormality Observed : esusas FTeirlmeidnalonsDaacyrif1 i1c7e5 AEnxipmoaslureiaGsriogunped+ oSfAfTELfrom necropsy Gross pathology : No MAaILOLIcREVrTUEoAMRs,,,copBPKRiAIANcDDCNNREa,EYbASnS,oS,rPImLCNUaNAClGLiUStM,Cy,ORHODCEb,OAsLNeOTSrN,Tv,OeNdSARKCEEHCL,TEUTMDA,LUONMDUEESSCNNLFLEE,RTSSSseirLeum,a 654908 Continued onRNOOtDhREeE,NAnLeSxAtGLLIApVNaADgRSeY, GSLACNEDFSI,CWANENRDVIEB,LLAPRITLOYRMAPRHYNGoLsA,D,mie --_ -YYY Company Sanitzsd. Dossnotcontain TSCA CBI O L"DaD yOray GN avagO eSyuin . Rl as 7GcugeSodyinoRoDwue sPosn9ns 47w8 ~ Showing anIinsdailviddautaal AfnoirmailndLiviisdtuianlg animals DsooseyGrowp III91 /no/1ka/day Sex: Males minal Ret Microscopic & Macroscopic Findings re Continued from previous page Gross pathology : Yo Ma`PTcHHrAYoRRsYOIcIKoD/pLGiALcRAYNADNb,Kn,orPEmAYaRElA(iTSHt)YyRWOCIIhTDsHeGrLOvAPeNTdDISC:, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SPEENMUIRN/AKLNVEEESIJCOLTENTS,, USRTIENRANRMY, BNLAODSDEER, TESTES, EPIDIDWNIORS, 554954 TKEexirplmolisenudarleonGSrDaoacuyrpif: i: c1Se75ATEL Aninal is signed off from necropsy Gross pathology : -- No MAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSm,`oSmPLaIONlNAiGLSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETADLUODMEUNSGCML,E, JSEPILUENEMN,, NAIODLDREEOE,NN,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNHIDCNSUT,NI,CMANCENORDLVOIENB,.ULAPRREICTILUOYIMMT,PAHRYMNEOGSDLEEAN,NTDE,SRiInCisYe,b TPSHIHAMYRIRYNOIAIXLD/LVGAELRSAYINNCD,GL,ESP,EAYREUA(RTSIH)NYARWROIYITDHBLGAOLDPADNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENSP,SIODPPIHRDAOWGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERYON, NOSE resEER eens. Company Saniized. DossnotcontainTSOA CBI C 5D 0.DsyD OraO lGy evageO S: yun Ral75Gk gsSutyinkDouwe reownes 9s47n8 --~ sooy :(RecorSmhaonweing anSiomdailvigduaatla afonri) miandLiviisdteiansg animals Dose Group EIT 1 mafkg/day Sex: wales Animal Ref Microscopic & Macroscopic Findings Sess KTeirlmliendalonSDaacyrif: ic53e AExipnoaslureiGrsoiugpn.ed+ oSf0fDAYtrom necropsy Gross rachology No MAaLOIcRVrTEoARs,,copKBRiIAcDLNNEA,YbSn,SoPrILmONaNAlGLiSt,CyORWODbE,sAeRrS,TvOeMSdAKCE:HL,ETDALUOMDUESNCNL,E,TSeesria,, ANIORLDEEE,A,L`SPAGRLLIIACVNRADERSAY,S,GLSACCNIEDACSSH,I,CWNCREODRLIVOBENU,,LAPRRSICTRULUIYNTM,APHRYMNEGOSbELRN,AFEDBREGoLnos FTHAYRROTID SEMINAL VGTELASARINCDYL,,ESB,EAYR2UA(RRSII)NRAORWIYIDTBHLGAOLDPADNTEDIRSC,, NTETRRRSVATEC,EKSE.RS:kiSnMB.ASDOIPPOARRAOMGSIUTBSAR,TGE,, FREE JOINT, STERN, HOSE sistopacholony : rm LIVERIN: FLATION, SUBCUTE/CHRONIC, minimal. Yo MiScIrOoNscSo,piTc RAbOmoTrmGaLlAiNtDy, ONbOsSeErved : --_ --_-- CompanySantized. Doesnot contain TSCA Cal ( 0-DayOralGavai geStudyin Rats 5 Dupont0478 -- Showing anIinndailvidduaatla AfnoirmailndLiviisdtuianlg animals DsotsueoyGr:o(upQ:RI2II6911/mnaa/lkea/day Sex: Males Aninal Ref Microscopic & Macroscopic Findings esas84 TKeirlmliendalonSDaacryif: ic9e3 AEnxipmoaslureisGrsoigunped: oSf0fDAYfrom necropsy Gross Pathology No MaLIcVrEoRs,coKpIiDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TOMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NALSAGLLIAVNADRSY, GSLACNIDAST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.THYMUS, TPHHYARROYIID/LGALRAYNNDR,, PEAYREN(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,KERS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNVEEESIJCOLDENSI,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPXDIDYMIDES, -- Histopathology L1veRFA: TTY CHANGE, MEDIAN CLEFT, minimal. KIDWESCSHRO NIC PROGRESSIVE NEPHROPATHY, minimal. Yo MiTcHrYoRsOcIoDpiGcL'ANADb,noNrOmSaElity Observed : -- -- me -- CompanySanitized. Doesnot conTtSaCAiCBnI CORY: vc 30O- ralDGaa vagy eStudyinRats DuPont-9478 ~ Individual animal Listing soe QR Shaoiweing aninal data for individual animals Dose Gop? WII 1 ma/ko/day Sex: Males Animal Ref Gases Microscopic & Macroscopic Findings ETKexirplmolisenudarleonGSrDaoacuyrpi.f:i: c1Se75ATEL Aninal is signed off from necropsy Gross Pathology : Yo MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OWbEsAeRr,vedSKE:LETAL WUSCLE, SPLEEN, ATOURETCAM,, PBRAANICNR,EASS,PICNEACLOMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLDiNt,h ASDORDE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULPAIRTULIYTMAIHRYNGODLSA,ND,TAMU, TFHHYARROIVD/LGALRANYDG,, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC. NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEMIUNRA/LXNVEESSIJCOLIENST,, SURTIENRAVRMY, BNLOADSDEER, TESTES, EPIDIDWNIDES, -- asesss TKoirlnliendalonSaDcayrif:ic53e AEnxipmoaslureisGsriogunped: oJf0fDAYfrom necropsy Gross Pathology Yo MaIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y WObEsAeRr,vedSKE:LETAL WUSCL, SPLEEN, TAOURSTA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,CMANENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,TRYWUS. 654995 Continued on the next page .... --~ 6 CompanySanitzed. Does not contTSaOAiCBn C 50DeyOO ralGavaR g Sry) in Rat . Toxicity Duron ~ Showing anIinmdailvidduaecla afnoirmailndLiviisatsianlg animals sDorserGRPRVIIIcn1 am/ikea/day Sex: Hales Aanal Ret Wicxoscopic & Wacrocopic Findings sass Continued ron previous page Gross Pathology : No MPa"TcEUrRoAOsIcKDo,pAiGcLRAUNaDNb,n,orFEmAYaR3lK(iI5tI)yROWTODbE.sTeGrLOvAPeNTdDISC,NETRRVAEC,HEAS,KINZ,SOPBRAOGSETSA,TE, FSENETNMALUVRBSIOCTLERS,, SURTIENNAL, BNL0ADSD8ER, TESTES, SRIDIOVMIDSS, Histopathology : Liven`ENeEmIYanCAiNoNGnE,, WStEeDAICAuNTCsLCERFRO,NEmi,nimmailn.isal. vwoeeoCshHROGNLIACDPROGRESSIVE NEPHROPATHY, minimal. -- AAEAATION, COLLOID, minimal. No Microscopic Abmormality Observed oon ~ --_-- Company Santzed. Doss ot contain TSOA OBI 2 S0D-- aD yOnlyGavy age. StO udyinRuas ioxcG ty uageudyinRDDue Puono9s 47s8 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianig animals DsotsoeovGr(ou2p 4n6V 95 1mg//kmga/ldeay Sex: uales Animal Ref Microscopic & Macroscopic Findings 654907 TKeirlmliendalon SaDcaryif: ic93e AEnxipmoaslureisGrsoiugnped: oSfOfDAYfrom necropsy Gross pathology : No MAaLOIcRVrTEoARs,,copBKiRIADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,GyOROHDEb,AsReTrS,vTOeMSdAKCE:HL,ETDAULODMEUNSUCML,E, JESIP-OLNEOEMN,, NIOLDEEU,M, SAPLAINCVRAERAYS,GLACNECDUSM,, MACONLDOINB,ULARRECTLUYMM,PHMENOSDEEN,TERTIHYCMULSY,MPH ATDHRYERNOAILD GGLLAANNDD,S, PSACRINATTHIYCRONXEDRVGEL,ANDPSI,TUTIRTAACRHYEAG,LANEDS,OPHAGUS, SPEHMAIRYNNAXL/LVEASRIYCNLYE,S,SYEU(RSI)NAWRIYTHBLAODPDTEIRC, NTEERVSET,ES,SKISNP,IDIBDRYOMSITDAETSE,, FEMUR/KNEE JOINT, STERNUM, NOSE -- Histopathology : LovesINFLAMMATION, SUBACUTE/CHRONIC, mininal. THROIFDATGTLYACNHDAN+GE, MEDIAN CLEFT, minimal. ALTERATION, COLLOID, minimal. No MiKIcDrNoEsYcSo,picNOASbEnormality Observed : --_ - = `CompanySanitized. Doesnot conTtSaCAiGnBI C 50.OrDGsavayge i s iy nRaite Toxicity Duron 9478 -- srooy (Qss1I Smhaotweing anIinndailvidduaatla AfnoirmailndLiivsitdienag animals Dose Grok + V 5 ma/kg/dey Sex: Wales Sminal not Microscopic & Macroscopic Findings Gesi KeirlmliendalonSDaacyrif: ic53e AEmxipnoaslureisGsriouumpe:d oSf0fDRYrom necropsy Gross Patholosy Yo MaLHIcOVrREoTRs,,copKBRiIADcINNEA,YoSr,SmPaILINlNAiGLcS,yCORHODbE,sAeRr`,SvTeOdSVKACE:HL,ETDALUOMDUESNCNL,E,JESTPULHEOERN,, NHTOLODEER,,ESELGATLNVACANKRDESYA,S,GLSACCNICDNUSFM,I,CWNAGEONRLDVOIEYB,,ULARPREICTTLUUIYMTM,APRHYNNEGOSLDEAENN,FDR,TIHC EL,iF FTERRNRRYOLD SETA VGLLEAASRNIYDCN,LXE,SPS,AVREGA(RT5IH)NYARWROIYITDHBLGALODAPDNTEDIRSC,, NETRRVAEC,KESRKINB,SOPFRRAOGSUTSA,E, TESTES, SPIDIOWNIDES, FRR JOIN, STERN, NOSE --_ Histopathology LaveneLmTION, SUSACUTE/CHRONIC, minimal. KooFsATT| Y CHANGE, MEDIAN CLEFT, mid THiRORCDRRGOLNIACNDPR OGRESSIVE NEPHROPATHY, mininal AUTSRATION, COLLOID, minisal. No Miocsrsoscopic Abnormality Observed : _ -- = Company Saritzea. Donotscontsain TSA Got C 50.DayOO ra Cam vageStudy-- in Raits DuPont9478 Showing anIinmdailviddautaal AfnoirmailndLiviisdtuianlg animals sDtoosepYGrCouNp )+1 :1559m1g//mkag/tdeay Sex: Males Aninal Ref Microscopic & Macroscopic Findings ases16 TKeirlmliendalonSaDcaryif: ic93e AEnxipmoaslureisGrsoiugnped: oSfOfDAYfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,omLaOlNiGSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETUMA,, BPRAANICNR,EASS,PINCEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODWEENSGENN,TERJIECJUNLUYMM,PH ANDORDEEN,AL',SAGLLTAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THYWUS, TPHHYARROYINKD/LGALRAYNND,K, PAEYREA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMMIUNRA/LKNVEEESIJCOLETS,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, -- Histopathology : LKaopvweeryIsNF-LATION, SUBACUTE/CHRONIC, minimal. CHRONIC PROGRESSIVE NEPHROPATHY, minimal. Yo MiTcHrYoRsOcIoDpiGcLANADb,noNrOmSaElity Observed : ~~ -- -- Company Sanitzed. Doss not contain TSCA C81 O9O0DayOr GavageSuds yinRc ats Toc Dupont 9478 --_ stove: (PY 24691/Smhaolweing anIinndailvidduaatla AfnoirpailndLiviisdtuianlg animals Dose Group 1 V 5 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings eset TKeirlmliendalon SaDcaryif: ic5e3 AEnxipmoaslureisGrsoiugpned: IofDfKYfrom necropsy Gross Pathology : Yo MaLIcVrEoRs,copKiIDcNEAYbSn,omLaUlNiGSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PINCEACLUMCN,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUENN,TERJIEJCUNLGYMMb,it ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITLUYIMTPAHRYNGODLEA,ND,THYWUS, TPHHYARRYONIKD/LGALRAYNND,K, 'EPAYREN(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, SFEEMNIUNRA/LK,NVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPXDIDYMIDES, Histopathology : LaverINFLAMMATION, SUBACUTE/CHRONIC, minimal. xaoveyNsECR:OSIS, POCAL, minimal. THYROICDHRGOLNAINCDPR+ OGRESSIVE NEPHROPATHY, minimal. `ALTERATION, COLLOID, minimal. No MiNocsreoscopie Abnormality Observed : -- -_-- Company Sanitized. Does not contain TSCA CBI C XDDyaOyuOiraGO luGaovgaegde0oR dyiinnRRaetss. 0 1c DDuuPmoanes7s Ps sor (24691 Smheonweing anIinpdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group #07 5 ma/g/day Sex: Males Animal nef Microscopic & Macroscopic Findings esis KeirlmliendalonSpaacyrif+ ic1e75 AEnxipmoaslureisGrsoigunpe+d oSfAfTELfrom necropsy Gross rathology Yo MAaLIGcVrREoIRs,,coBpKRiIADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsNeEr,SvTeOdSNAKC:EHL,BTDLUODWEUNSGCHL,E, JESPTLOENEMN,, AOTDDLREEE,N,ALSAPGALLNIACVNRADERSRY,S,GLSACCENACDUTSMI,NC, MANCEONRLDVOIENB,,ULPARIRSTCRULURYNTN,AEHRYNNEGOSLDEAENN,FDE,TRIHCUDLT,NFH STSHHEYARRIOIND /VGLELASARIIDCN,L,ESS,ERYR3UK(RFSIA)NYARWROIYTTDHBLGALODAPDNFEDIRSC,, NETTRRRVSAETC,EHSE,RS,KISNPE:ISDOIFRDRAVOGMGUIPSDR,ERSE,, SEUOR/KuEE JOINT, STERNGH, HOSE PS esesze KTeirlmliendalonSascaryif: ic1e75 AExipnoaslur1e5Grsoiugpned+ oSfAfTELfrom necropsy Gross pathology Yo MAaLOIcRVrTEoARs,,copBKiRIADcINNEa,YbSn,oSrPImLNOaANlGLiSt,CyORMODEb,AsReESr,TvOeMdSAKCEHL,ETADLUODMEUNSGCHL,E,JESPULNEEENN,, ANIDLOREDGE,MN,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCNSLT,MI,CMACNEONRLDVOIENB,,ULAPRREICTTLOUYVMNT,EAHRYNOEGSDELENA,PNEDTRIHCUGLY,MPH 634526 Continued on the next page -... ~ e e e --e -- s Company Sanitzed. Does ot continTSCA GBI OyOrR al avage Y StinaRys: 10:4) Dupont 9478 ~ Individual Animal Listing stor os Sehaoweing animal data for individuss animals Dose GroU NY 5mg/kg/day Sex: Males Amina Ref Microscopic & Vacroscopic Findings ssaszs Continued from previous page Gross pathology : No Ma`TcHrYoRsOcIoDpiGcLANADo,mPaAlRiATtHyYROOIbDseGrLvAeNdDS:, TRACHEA, ESOPHAGUS, SPEHNAIRNYAICL/LVAERSYINCKL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYONSITDAETSE,, FENUR/KNES JOINT, STERNUM, NOSE ssasss TKeirlmliendalonsaDcaryif: ic9e3 AEnxipmoaslureisGrsoiugpned: oSf0fDAYfrom necropsy Gross Pathology Yo MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,vedSKE:LETAL MUSCLE, SPLERN, -- AIOLRETUAN,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UOMDEENSUEMN,TERJIECIUNLUyM,i ANDODREE,NALSAGLLIAVNADRSY, GLSACNIDNST,IC`MNAENRDVIEB,ULPARITULIYTMAPHRYNOGDLEA,ND.THYMUS, TPHHAYRRYOIICD/LGALRAYNID,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HERS,KINE,SOPPHRAOGSUTAST,E. PSEEMNUIRN/ARLNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EFIDIDYHIDES, sistopatholosy 654559 ContinueLdavoenrItNhFeLnAeTxItOpNa,geSU.B..A.CUTE/CHRONIC, minimal. ~ --_-- Company Sanitzed. Doesnotcontain TSCA O81 RCOdDyaoyuOnGeGaeraggSeSuyyinkFeis:0 1:5 oDwuorwonoonuss PP Shouing anIinmdailvidduaacla AfnorimailndLiviisdteiensg animals DsooverGrQoEw TV e56sm1a/mkapt/easy Sex: Males minal ret Wicroscopic & Nacroteopie Findings pre Genitend From poveionn poi Histopathology + R-- OTCHHROGNIhC PR+OGRESSIVE NEPHROPATHY, mininal. ATSRATION, COLLOID, mininal. So Niocsrsoscopts Abmermaliy Ghaerved : ssasen BKTxieplrolmsieundraelonGsbarecoyrwif+ i+ c5e3300AY aioal To signed off Econ necropsy Gross Pathology : -- BHEOVRETE RA., BKRIADINNE-- ,YS,SPILNUANGLS,CORHDESARSTTOMSAKCEHL,ETADLUOMDUESNCCLHE,TsopLhzm,, RIOOL0RBEE,H,ALSAPGLALNIACVNRADERSAY,S.GLSACCNIBDASMT,E,CWANCENORLDVOIENB,,ULAPRRSRCTRLUUYYNMM,PRHENNEOGSDoAEaI,dE:RTEAGMEM,e SFTEHAMNAIRNOAILD VGALERASNIIDC,L,ESP,BAYREDK(RTSIR)NIARWNOIYTTDBHLGALODAPDNTEDIRSC.,NERMRRAVECERH,EESR.S.KIbNiR,RDOiPBoHRvAOGMGUITSDA.S,FSE,, FERKgs OTT, STERN, NOSE 654361 Continued on the next page .... ~ ------------------egoen eeses-------- Company Santizd, DonotsconstainTSCA Cl O 50 Duy rl Gevege c tynf. cs Drom _ Showing anIinedatlviddueacla nfotrnaIlndsiviissteisntg animals sSoorerGEAN2DY45 6rasmv9eatrsaay Sex: ales pc Nicroreopis & acroncopie Findings Geiser EE A iscopacholosy J aveIAPLAGORION, SUBACUTE CHRONIC, minnal. ESRONIC ROCRESSIVE NEPROEATHY, minisal. AoroLaRION, COLLoTD, minis. to M5icroscopic Abnormality Observed : eses67 TnEeereemeiaonraenl: cSaoactrrei'f:ic582e 0m La seb of teem necropsy _ ross Pathology : No Mfaocvrreonsi.cocpEiIicmEeArbeam,ormToaosldei,yiDooObAsaNeEr:rvedSieG:yLETeAL wSiCLE, hSpLrEmy. SNSoEOsERN,E,LSBAGALNDcARSREYA,S,SECLoALCRUIHC.KCMOEALROENB.. ARPGrCrRi OUTRR.RYBmEgSneNn,FiEo:ARLSRL,EH TTSTAIERRnONRRDeEVGRLASIaTRO,oL,EuS,P,BASYTSAReRADTtNIaRWSO,IDTBiGaLOpAPoNImDnSS,, NTeEvARa.GBBheESioDeTIHRSAGGeGEAISRE,ESE.. 650567 Continued on tho next page... - . ree =gaoes l -- s -- CompanySaiized Dos notcontin SOA Gal (5S0.DEayOralGavageSui.cnR.yee Toxicity Duponcs478 --_ oor (R1S2howing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals Dose Group W 5 n/rg/day Sex: Males Aina Rot Microscopic & Nacroscopic Findings Saver Continued from previews page Histopathology TLHaYvReOnTPDLAGILNATDIO N, SUBACUT/CHRONIC, minimal. ALTERATION, COLLOID, minimal. Yo MiKIcDrNoEsYcSo,picNOSAEbnormality Observed : esasss TKeirlmliendalonsaacyrif: ic1e75 AEnxipmoaslureisGrsoiugpned+ oSfAfFELErom necropsy Gross Patholosy ~ No MaLHOIcRVrTEoARs,,coBpRRiIAcNIENAY,bSn,oSrPLmIUaNNAlGLiSt,CyORHODbE,sAeRr,SvTeOdSWKACE:HL,ETDALUOMDUESNCNL,E,JESPTLUENEMN,, NHTOUODEEOR,N,ESAEGLALINACVNRADERSRY,S,GLSACCNHIDCASOT,MI,CWANCENORLDVOIENB,,ULAPRREICTRLUOYINMT,PAHRYMENGOSDLEEAN,NTDE:RMIVCHSLI,NFH TPSEHHMYATRRNOYAIILDGHVG/ELLSAAINRCDYL,,ESB,EAYREOA(RT3DH)UYARWROIYZTDHBGLLAODAPONTEDIRSC,, NETTRERVSAETC,EHSE,AS,KOENPE,ISDOIPPHDRAOOGMSUITSDA,ETSE,, SEMUR/KNEE JOINT, STERN, NOSE _ e --t ---------- Era ------ ge--t ---- s CompanySait. DossnotcontTaSiCAn CBI C 90-Day Oral Gi avage Suey in. Rats 0c DoDupmonta94n78 ~~ smopy (comSheowing anIinmdailviddautaal AfnoirmailndLiviisdtuianlg anirals Dose Group V 5 ma/ke/dey Sex: ales Aninal Ref Microscopic & Macroscopic Findings 654570 KTeirlnliendalon SaDcaryif: ic1e75 AEnxipmoaslureisGsriogunped: oSfAfTELfrom necropsy Gross Pathology No MAaLOIcRVrTEoARs,,copSKRiIADcINNEA.YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMSdAKCEHL,ETDAULODMEUNSUCML,E, JESJPULNEUEMN,, ANIODLDREEOE,MN,ALSAPGLALINACVNRADERSAY,S,G`LSACCNEIDCASUT,MI,C`MNCAEONRLDVOIENB,,ULPRAERICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTIHCOMLSY,MPH SPTEHHMYAIRRNOYAIILD/LVGAELRSAYINNCDX,L,ESP,EAYREUA(RTSIH)NYARWROIYITDBHLGALODAPDNTEDIRSC,, NTETERRSVATECE,HSE,AS,KIENPE,ISDOIPPDHRYAOMGSIUTDSAE,TSE,, FEMUR/KNEE JOINT, STERNUM, NOSE --_ s54080 KTeirlmliendalon SaDcaryif: ic93e AEnxipmoaslureisGsriogunped: oSf0fDAYfrom necropsy Gross Pathology : TesTEsSUALL, ONTLATERAL. 654980 Continued on the next page .... ~~ _-- ae Company Sanitized. Does notcontainTSCA Cal O yOral GavageSc tuy inRats ty DuPone9478 --_ Individual Animal Listing smupy Cy:cco:S7h1ow0ing animal data for individuai animals Dose Group NV 5 na/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654580 Continued from previous page Gross Pathology : No MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN., ANIDOLDREEEH,N,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUTM,I,CMNACEONRLDVOIENB,,ULRPAEIRCTTLUUYIMMT,PAHRMYENGOSLDEAENN,TDE,RTIHYCHULS,eb STPEHHAMYRIRYNOMAINLDE/VGLELASARINYCDNLK,E,S',EPYAERU(MRTSIH)NYARRWOYITTDBHLGAOLDPADNTEDIRSC,, NEETRRPVAIECD,HIEDAYS,MKIIDNEE,SSO,PPHRAPOGSEUTMSAO,TRE/,AIEE ome, STERNUM, Nose Histopathology : --_ LrvemINFLATION, KIDNEYS : SUBACUTE/CHRONIC, miniral. THYROICDHRGOLNAINCDPR: OGRESSIVE NEPHROPATHY, minimal. TESTESALT:ERATION, COLLOID, minimal. 'miDlEaG.ENERATION/ATROPHY, SEMINIFEROUS TUBULES, UNILATERAL, DILATATION, SEMINTFEROUS TUBULES, UNILATERAL, moderate. Ho MNiocsrzo.scopic Abnormality Observed : ---- Ts ------ CompanySanitized.DoesnotconTtSaCAiGBnI O D 50.DaD y OralwGY avaO ge Semy ini ) RatiscG Toxicu ity agetndyinRbDuwpee onwto9s 4s78s -- Showing anIinmdailvidduaatla AfnoirneilndLiviisdtuianlg animals Dsotsoep GrAoup)+0: c5osm:a/nkaai/eday Sex: Males Aninal Ret Microscopic & Macroscopic Findings 656561 TKielrlmeidnalon SDaacyrif: ic1e75 nBxipnoaslureisGsriogunped: oSfAfTELfrom necxopsy Gross Pathology Yo MLAaOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORHODEb,AsReTrS,TvOeMSdAKCEHL,ETDAULODMEUNSUCML,E,JESPOLNEGEMN,, ANTDOLDREEGE,NN,A|LSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,NI,CMACNEONRLDVOIENB,,ULRPAEIRCTTULUIYMTW,AFKRMYENOSGDLEEAN,NTDE.RTIVC SL,YMPH STPEHHAMYRIRYNOIAINLDX/VGLELASARINYCDNL,KE,SP,SAYRSUA(RTSIH)NYARWROIYITDBHLGALODAPDNTEDIRSC,, NTETERRSVATECE,ESR,S,KIENPS,ISDOIPPDHRYAONGSIUTDSAE,TSE,, FEMUR/XONES JOINT, STERNUM, NOSE ~ ss4998 TKeirlmliendalonSaDcaryif: ic93e AEnxipmoaslureisGrsoiugpned: oSf0fDAYfrom necropsy Gross Patholoay URINARDYI.LABTLAATDIDOENR, :moderate. 654998 Continued on the next page . -- _--m-- oe Company Santzad. Doesnot conTtSaCAiCanl 20D) OlGaveSey nfnooi Toy Duponssirs ~~ DsorseoGroup ND s5emoeo Srihgoe/vainnyg anIinmdailvidduaatla ATnoirmailndLeissiteisnsg sex: wales aninals sina so Wicrascopic Nacrasopie Fiting Ga Continued trom previous pave Gross sachotosy : No MTaLIcLVrEEoR,s,coEo KpRIiNDcCNRSAEYmASoS,r,sLaCUiNoiGCSt,y, WOCbEsONe eNLr.,veSdRKSE:CLHEUTRALL NMosEcisS, Eseiasi,e SPTHNHEHOOANDYRNEIR,NOEAIALDSK/VGGLLEALILSRAVIIANANCDSRRL,Y,,ESPC,S"ALSERYTIABS0NT(5TT,R)LYSCRSWON,NIiAEDDmBRTVeGSECLO0.oAPiNTToDRAPwSCRe,rNeSEAnomReeOMAnRatnmBsyopnnSom,eepAeGasUtS,e, Sree, ross iinRe: Fene Tan, Histopathotogy : ~ cvorpvieenrIsN FLATION, SURMCUTB/CHRONIC, minipai. CHAGNIC PROGRESSIVE NEPHROPATHY, mininal. mornoAsUhTEGRiNTsEON, COLLOID, minima. No MiRcziosncopiScADADmEoR,maoliety observed : ~~ - CompanySaiize.Dossno conTtSaOAiGnBI C50DaRyOnY lGa.vSa. ygein . cy Duronsi7s PS Showng anIinmdailvidduaatl aFnoirmadlivviisdtien)g anisals soe Osis ms Dose Group Sninal ref :V 5 mg/kg/day Microscopie &SexW:eerMeasleeespie Fintines pe DKTerirenlsiesneeslonSspaeacayryifi+ c5e3SUIT Anat Ls ones off Econ necropey Gross patholo + No MaTALicCLvrTeonEns,,copABRiRIRAcDCINRNBAE,vbRSnS,oS,rPITmCNaGAlBsLiMt,Cy,ORMODCEb,OAsLNeOTSrN,Tv,OeMSdARKCEE:HCL,TEOTRDA,LUNWDESSECNL:PEE,RTLsCoersLo,,m ETNRROIDDRREROE,IAS,SAGCGLLLATAaARNwRYDnYN,s.,, PGBSLAAYCRNIKEDNTSSSI),EVCRWOYILNATDENHRDVGIELOB,APONTDAIFSCRR,TUNLMETYERRMAVPAREHCY,.ERRGSo.HRIu,RR.:ebRPBAHAAGRGRUENSE,E, ESEEMIRNEVESITCoLEmS,, USRTIENRIANY, BHLAOD0DER, TEGTES, EeiDISRERES, ~ [IR-- Laven INFLATION, SURACUTE/CHRONIC, minimal. ie ---- %0 MiEceroesc,opiRcoAssbmomality Observed : sc t m----T-- E i-- es in-- ti---- ------ Company Santzd. Doss not contTSaCAiGanl Y 50.Dsy Os Gavc iatyignRtee vic Dupont9478 --~ Showing anIinmiavlidgautla AfnoirmailndLiviisdteien)g animals DsoTsuepyGroup "WIT 715 nmga/ekg/day Sex: Males Satna ot [---------------- esis SKeirrlpmloienndraelonGSrbaoacuyipi.t+ ic1Se75NFEL Aninal 5s siamed off from necropsy Gross pathology : Yo MAaLOIcRVrTEoARs,,coBKpRIiADcINNEA,YbSn,o`SrELmIOaNNlAGiLSt,CyORWODEb,AsReTrS,vTOeMdSAKCE:HL,BTDALUOMDUESOCRL,E, ISSyeoLrEeeR,, ANIDOLDREEE,N,ALSAPGLANIiCVRAsERA,YS,GLSACCNBIDONSUT,NI,CWAGNEONRLDVOIENB,,ULPARIRETCTULUIYMTM,APHRYMWESGOEobMaEYdER:FCG.eL,abi STEEHEUYAIRRNOYAIILD/VLGELASARINYCDIL,,ESSS,RVAEUTR(AI9I)NRAORWIYITDBHLGAOLDPADTEIDRC,, NTETERRVSAETC,EHSE.RS:KBnRM.SYODPPIARDNOIGGUISSNE,ESE,. FERKEE JOINT, STERN, OBE esesa0 ~ KETxeiprlomlsieundraelonGsDraacoyruipf::ic1Se75ATEL Animal is signed off from necropsy Gross Pathology No MaALOIcRVrTEoARs,,coBpKRiIADcTVNEA,YbSm,oSrPLImINaNAlGLiSt,GyORMODEb,AsNeTrS,TvOeMdSAKCE:HL,ETDALUOMDUESRCCLHE,TSaPaLEmEN,, ANIDOLDREEE,N,ALSAPGLANIiCVRAsERA,YS,GLSACCNBIDCNSUT,NI,CMNACENORDLVIOEB,,ULPARLRETCTOLUTYMIM,APHRMYENSOGEDoNAaY,dER,SCS.mLtPH 656520 Continued on the next page .. --_ --_--_---- Company Sarita. Dossnot containTSCA Gat C20RDiyOr Caves tsy in:fo 7:51 Duronis7s DsooserGr(oupEMUsLT s35Smmhooaon/wskien/gdaaynfntdeisvidsdeuuxae:l AontisaSdndLbritsotiinn)g ales anivats pee Wieroscopic & Hacrorcopte Fintinms seane Gant usd tron previous pean -- 40 FMHSaAcRrEAoosrTScDopVGAiELcRSAINAICDb,L,mEoSrPE.mVaGAiRi(3Ec)ANyARWGREIbRsBHeirCsSvLbeRadSmCn,:. emTRvRAeeCeHsE.Aa,rmnEiSoOPoaHAGaoIS,rn eyapsediat he ssisz2 eErreoromevianrane) Gseeaocnrro.if7i5c83e05m SE om socuorey Gross Pathology --~ 40 MTRaoigavrtemhns,,epBKhAniTsS,o,nSssoTmaoAtuisn,CyORWeDea,enrS,vroolSuMELH ESownca,sseorra, TON0Ro8O,mDaSAGGLLLIAVANADDR,SY, PGSLACDKIGIN:RCOHTR.ARBS,EEAAR"cSSS,arCiSooreaNeammnoaTsaeaLE, PFSAEnATRRIa/tVEeEASIsRCIoL,EmS,.VSSCN(r3I)eNAeRW,YIMBAGROC, NTeeeens.ptBreiDaAtTAsLE,! Hormprstiiogy + 650522 ContinueJ d onNINSeLceromsesm,zoarNgo,ec"aS,UmRinGiEmaA.ROVIC, minimal ~ -- Company Santzed. Dossnot contTSaGAiGBnI O nyOY re l5y n:o 1, -- Showing aInntdeisvidduaacla AfomrinSandbLviisoteien)g aninals sSorroaveo(rRoaIsIsEo10mmoanfsvartay sex: ales rail Wioroseoris & acroseopic Tintin son Canineed tron previous pave Histopathatoy : J--AL--FSAA--TRON, COLLOTD, minimal. No icroscopic Abnormality Observed : Dwromonrs ostsa RETreareomnitanraeel dshaeactrroi'fTi+cs2e0mae Eas amd o48 com nacxopey Gross Pathology ~, Ho Mr aELcvEreEons,,coi pKoiaIncocNRAYEbSae m,So,mLaColasCist Uc,ny. DOCEbOasLny eOnrR:v.edGMCG:Si LREMTA.L MEUSSECMLAEE,RCsSeLzpaNo, FHNTioIOnnNEiR,naOgL,DShRGCLILDva,AsR,,Y SPLSBREGYAHERT)IIRCOWMLTISEERRGEELP.ARRNCPARE,eETrBReoGAGaHESRgB.omanNt,RSmaCeaSnro,s, STEnENeVeESISCoLEuS,, CaAmDIaAnNY, BwLAbaoRR. BRSEES. BeiDESISLE: oopathotoy + 650525 Continued on'rIhNeeF.LsAneTeIkeOpNM ,oSnUeB"ACUTyE/CHRONEE, minim. ~ s-- e ----e-- nee ---- ---------- --een Company Saized Doss notcontTSaCAiGBnI C'90-O DayOralMGavageM Sty i: nRats ici DuPont 9478 --_ Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals DsotsoerGrofufp * 2VI4I69215/mmga/lekg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654923 Continued from previous page Histopathology : xIDNECYHSRONIC PROGRESSIVE NEPHROPATHY, minimal. THYROHIYDPEGRLTARNODPH:Y, TUBULAR, minimal. ALTERATION, COLLOID, minimal. No MiNcOrSEoscopic Abnormality Observed : 654930 TKeirlmliendalon SDaacyrif: ic93e AEnxipmoaslureisGrsoiugpned: 90DAY off from necropsy Gross Pathology : No MaLIcVrEoRs,coKpIiDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, AIOLRETOAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLGYHM,PH ANDODREE,NAL'SAGLLTAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THYMUS, `PTHHAYRRVONIXD/LGALRAYNNDK,, `EPYAREA(TSH)YRWOIITDHGOLPANTDISC, NETRRVAEC,HEAS,KINS,SOPPHRAOGSUTSA,TE, SFEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPYDIDYMIDES, 654930 Continued on the next page .... ~ _-- 755 Company Sanitized. Doesnot contain TSCA CBI COM-DayOralGe avageS ytiRnRyai tes icy DDuuPPoonmtt9d47n8 ~~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDtouspeyGLroupop)W:IIcc2c51/mz2g2/kg/day Sex: Males Animal Ref 650930 Microscopic& Macroscopic Findings Continued rom previous page Histopathology + LIVER KIDNEYISNFLAMMATION, SUBACUTE/CHRONIC, minimal. CHYHPREORNTIRCOPPHRYO,GRTEUSBSUILVAER,NEmPiHnRiOmPaAlT.HY, minimal. `THYROAILDTEGRLAATNIDON:, COLLOID, minimal. No MiNcorsoescopic Abnormality Observed : 654933 KTielrlmiendalon SDaacyrif: ic1e75 aEnxipmoaslureisGrsoiugpned: SATEL off from necropsy ~ Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE:LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIEJCUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULPAIRTULIYTMAPHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNNDX,, `EPYAER(AST)HYRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTAST,E, FSEEMMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, _-- 756 `Company Sanitized. Does not contain TSCA CBI O 2S 0 Crd GrR egyiy . o1u c Gmeenr oDwupee onsons --_ sor ceonShsowing an[ ieat et-- n bon aa-- betoent anions ore Oh marnarday sex ates Tr Hirose & maccoscopie Finite erEee HT on mecropey Wo Noaar cznnossopB Ec teAsab,mr orTmoattesi,oy Saaohmmea redLi :TAoeeT NOLSECL:ER,SSEPLLAESHE, B r a ce i hen Tae cOa DSr LpYe,adRSECoeTt, sCaMSLmonDTsE,RLnCsLn, a Fra , d ey aO Ll ssisao J Emad 2umkeen mocropey ---- J orvirRoveers, Teves, -- Seai m, Sruaemsr , wscrs,e sess, a R SEE,ESanEnin,i Cavan, Geum, SairoOvLIaTErNLLConi 650540 Continued on the next page ... --_ A = CompanySarita. Doss otonSaOAGnBI C obG yo e: e nct Ggthiat--wwe _e spars lSlE SEE dots Sstovee (o@E)2651mmaelterartar sexs ates Seinen rer iesoscapic & Tasreveasia Fini pr Somat Tm sea cross sachatony 5TeStonsekeS ESER T GaA, Tiet 4 ving, soTmai,, ts aA Si -- sevenrCi enusnigon,Rsowgcurs/camorzc, sini. _ eyESreSiin,armoenoiny,,csouomra,n,minniinnaal.. 1 Wipsraoscopic Rmormatity observed : ssi Sm ermonr s sace risice BEL Wh on soonest Servet R Ee TT gpT,I. SEmAhR,Shaoyosk,y,ssisa, Saeimss. EE a ia eerie e orgies Company Said. Doss otcatsinTSCA CEI $0-DayOra GavageSaySuibncRaotnsic Toxicity Dupont9478 ~ Showing anIinmdailvidduaatla afnoirmailndiLviisdtuianlg anisals DsotsoenSyGr--ow)p :"WIcI 125 mmge/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings esa52 Continued from previous page Gross Pathology : Yo MaTPcHHrYAoRRsOYcIIoD/pLiGcLAARNAYDbN,n,orPBmAYaRElA(iTStH)yYRWOOIbITsDHerGOvLPAeNTdDISC,NETRRVAEC,HEAS,KINB,SOPPHRAOGSUTAST,E, SFEEMNIUNRA/LKEVEESIJCOLTENST,, USTREIRNNAORMY, BNLOASDEEN, TESTES, EPiDIDWIOGS, Histopathology LaveRINFLATION, KIoweys ; SUBACUTE/CHRONTC, minimal. THYROIHDYPGERLTARNODPHY, TUBULAR, minimal. ALTERATION, COLLOID, minimal. --_ No Miocsrsoscopic Amomality Observed : sess TKielrlmeidnalonSDaacyrif: ic53e AEnxipmoasluriesGrsoigunped: oSf0fDAYfrom necropsy Gross pathology : No MAaLOIcRVrTEoARs,,copKBiRIADcINNEA,YbSn,oSrPImLNUaANlGLiSt.CyORHODEb,AsReTSr,TvOeWSdAKCE:HL,ETDAULODWEUNSUCML,E,JSEPTLTEAa,, ANIDOLDREEUE,MN,A|LSAPGLALINACVNRADERSAY,S,GSLACCENICDNUSTM,INC, NACNEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRMYENOSGDLEEAN,NFDE,RTTHVCNULS,bs 654958 Continued on the next page -.. -- - =m Company Sanitized. Doesnotcontain TSCA CBI Day iunbcRhartosnic Toxicity Dupont5478 ~ Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals sDtouspeyGrJ oup::iVIcs25/mmagl/ekg/day Sex: Males Antnal Ref Microscopic & Macroscopic Findings 650958 Continued from previous page Gross Pathology : No Ma`PTcHHrAYoRRsYOcIIoD/pLiGAcLRAYNANDbK,n,orPBmAYaRElA(iTSHt)YyRWOOIIbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTAST,E, FSEEMNUTRN/AKLNEVEESIJCOLETS,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDWIOES, Histopathology : LIveRINFLAMNATION, FATTY CHANGE, SMUEBDAICAUNTECL/ECFHTR,ONImCi,nimmailn.inal. xIowEyNsECR+OSIS, FOCAL, minisal `THYROCHIYHDPREGORLNTAIRNCODPPHR:YO,GRETSUBSUILVAER,NEmPiHnRiOmPaAlT.HY, minimal. ~ ALTERATION, COLLOID, minimal. Yo Mixcorsozscopic Abnormality Observed : -- ---- Hea -- Company Sanitized. Doesnot conTtSaCAiCBnI O 90.Day Ors CavageSyc inRass ois Duport478 -- Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDtouspeyGrCoth5WW5II2252m2a/0ko/dey Sex: Males nina Ref Microscopic & Macroscopic Findings perern TKeirlmliendalonSDaacyrif: ic1e75 AEnxipmoaslureisGrsoiugpned oSfAfTELfrom necropsy Gross pathology : Yo MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y RobEsAeRr,veSdKE: LETAL MUSCLE, SPLEEN, NAIOOLDREETG,AN,, SAPBRALANIICVNRA,ERAYSS,GPLIACNNEADCLSU,NC,ORMDCA,ONLDOISNBT,OUMLARACERHC,TLUYMMD,PUHODMENENOSDGEEMN,,TERTJIHEYCJMUULNSYN,,eH APTDHHRYAERRNOYAIILDX/GGLLLAAARNNYDDN,S,, PEASYRCEIA(ATSTH)IYCRWOINIETDRHVGELO,APNTDIPSCI,TNUETIRRTVAAERC,YHESG,KLIANNB,DS:OPPRHOASGTSA,TS, FSEEMUNDUARL/KVEEESIJCOLINETS,, USRTIERNWAURNY, BLNAODSDEER, TESTES, BBIDIDVHIDES, esesns ~ TKeirlmliendalonSaDcaryif:ic3e3 AEnxipmoaslureisGsriogunped: Sof0fDAYfrom necropsy Gross Pathology : No MaLIcVrEoRs,coKpIiDcNEAYbSn,ormLUaNlGiSt,y OHbEsAeRr,vedSKE LETAL MUSCLE, AORTA, BRADN, SPINAL CORD, STOMACH, DUCDENGM, JESSPULNEUENN., NIOUDEEU,K, SAPLAINVCRAERAYS,GLACNBDCSU,N,MACNOLDOINB,ULARRECFLUYMM,PHMENOSDEEN,TERMIIC SL,YMPH ADRENAL GLANDS, SCIATIC NERVS, PITUITARY GLAND, 654975 Continued on the next page -.. . --_-- Company Sanitized. Dossnotcontain TSCA GBI CL9O0DDayOOrualCGnavuaggeeSSot3dy:yiinnRRatavssic Tice DDuuPoonme9o478 ~~ Individual Animal Listing stoov Showing (24691 /male animal data for individual animals Dose Group + VII 25 mo/ka/dey Sex: Males Aninal Ref Microscopic & Macroscopic Findings 554975 Continued from previous page Gross pathology No NTaHcYzRoOscIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, SSOPHAGUS, SFPEEHMVAIURNRYAN/XLK/NLVEAEERSYIJNCOKILN,ETS,,EYEUS(RTSIE)RNNAUWRMYI,THBNLoAODSPDETEIRC, NETREVSET,ES,SKIENP,IDIPDRVOMSITDAETSE,, Histopathology LavenNE:CROSIS, FOCAL, minimal. KIDNEYHSYPE:RTROPHY, TUBULAR, minimal. THYROAILDTEGRLAATNIDON:, COLLOID, minimal. ~ Yo MiNcorsozscopie Abnomality Observed : 654989 TKeirlmliendalon SDaacyrif ic5e3 nExipnoaslureisGrsoiugnped: oSf0fDAYfrom necropsy Gross pathology : Yo MAaLOIcRVrTEoARs,,copKBiRIADcINNEA,YbSn,SoPrImLNOaNAlGLiSt,CyOROHDEb,AsReTrS,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JESJPULNEUEMN,, ANIDOLDREEEU,MN,A|LSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMACNOENLRDOVINEB,,ULAPRREICTTLUUYIMWT,PAHRYMNEOGSDLEEAN,NTDE,TRHIACAULSY,MPH 654989 Continued on the next page .... --_ _-- Tas `Company Sanitized. Doss not contain TSCA Cal CMOoRyYo e)e u 0 .ctGwetembopwue erso ~ Showing arstnoinotrinsieztss tShuIs pRretSing inate sruvy (ull) 24691 mratein se ates Nini ar ices + Wacsoseania Finiioes PA Concimna Tvon pessoas some ore act A -- E fSirneeSa sIEn,epilrens MsornrisdVERuE,SON, soomaste. -- I sevenirueaion, SECTS, stain. SL SntaT s sarSSg EIYE Vi ESEY, niniost. eroncw, CID, sisi. --_ 4 wFisgs senereesass toeereet + Oeent atonee ecronny J ooTvorernn,s STRiaancnnhea,S,Taopnens,mSoen,eprSabUuBtLrEnSTsM,oIsscRcuae,n,,GssRmIvaN,., oNomrmaSoheaa,Cseent;oMADy ERAAECLCT MoEoSrEN,TERLIiC -_-- Compr Sid, Sopp TRAGEY O A Y vc ct -- ~ T sro pp sie on F[ LEE B-- IBL ote FI aon ER py ep cries shat aET I E tinEnsM ,icSeaLEntniTSrw iStr Lt'.y steS,h rsonmgs ~ asso mnmri, sascinscanon, sini. nCA LrTEY so sialman meet theemeet ETI RLIsSssBe ene oSE omEn,ST eTrevE nsa CAosYse,n eT o,raSl L a mCso myveso,,s,osmaym ~ A=L Comms, TAS O9R0.DayOralGavagoStudy inRatsic ovis Dupon9478 -- Showing anIinmdailvidduaatla AfonrimiandiLviisdtuianlg animals DsorseoGrbo p : s VIT 25e ma/ka/dsy Sex: ales Animal Raf Microscopic & Macroscopic Findings prey Continued from previous page Gross pathology No MaD"NHcYArRRoOYsTIcDOo.Up/GiLLcAARNYADNb,Kn,oPmASaVRlBAi(TStH)yYRWOOIbITsDHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTAST,E, FSEEMMIUNRA/LRNVEESSIJCOLIENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, EPIDIDYMIDES, Histopathology : KLIaovNeErYISNFL- AOITION, SUBACUTE/CHRONIC, minimal. `SCArPsE,RTRmOiPnAiYm,al.TUBULAR, minimal. THYROAILDTEGLRAANTDI.ON, COLLOID, minimal. --_ No Microscopic Abnormality Observed : ose ee Company Sanitizad. Doesnot contain TSCA GBI CO90MDayOralGavage StiunRdatysic Toi DuPont 9478 --~ Individual Animal Listing Showing animal data for individual animals stoov (fy2691/male Dose Group : IX 125 mg/kg/day Sex: Males ninal Ref Microscopic & Macroscopic Findings ss6506 TKeirlmliendalon SaDcaryif: ic1e75 EAnxipnoaslureisGrsoiugpned: oSfAfTELfrom necropsy Gross Fathology No MaLIcVrEoRs,copKiIcDNEAYbSn,omLaUlNiGSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, IALOERUTMA,, BPRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDORDEEN,ALS,AGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITLUYITMAPRHYNOGDLEA,ND,THAMUS, TPHHYARROYINDE/GLLAARNYDN,, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEENMUIRN/AKLNEVEESIJCOLIENST,, USTREIRNNAURMY, BNLOADSDEER, TESTES, BPIDIDYMIDES, -- sse1 TKeirlnliendalonsDaacyrif: ic83e EAnxipmoaslureisGsriogunped: oSf0fDAYfrom necropsy Gross Pathology : Yo MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y OHEbAsReTr,veSdKE: LSTAL MUSCLE, SPLEEN, IALOERUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECIUNLUYHM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITLUYINTPAHRYNGODLEA,ND,THOUS, 654914 Continued on the next page -- - = `Company Sanitized. Does not contain TSCA CBI ODayOR nlCavaY ge S) tinRyas : oc Dupont 9478 Pa Individual Anima Listing soov :(Ress: Smhaoweing aninal data for individent animals Dose GroWWLL 125 mg/kg/day Sex: Males Sind Ref Wioroseorie & Macroscopic Findings peren Goines From previo pee Gross Pathotony No MTacRroOscTopGiLcANADb,normFAaRlKiTtIyYROObTsDerGLvAeNdDS:, TRACHEA, ESOPHAGUS, FSAERMRINNLCVABRSIYCNL,ES,BY3U(R3I)NAWRIYTHBLAODFDFEIRC, NETREVSET,ES,SKIBNP,IDIPORMOMSITDARTSE,, SRE JOIN, STERN, HOSE nistopathology LavenPERTRORY, MEPMTOCELLULAR, minimal. fo IeRRTRORIY, TUSTAR, mininal maCHRONIC, PROGRBSSIVE NEPHROPATHY, minisai. ~ ruaY;or eraser. cocos`woonr erzsa exes. secaNor; pnssawr. MESENToErRICpRLzsuaeT. NODE + ROTAUrEGRLAATNIDON, COLLOTD, mild. 654514 Continued on the next page -... ~~ we CompanySaitzed. Doesnot conTtSaCAiGnB CR .-:Tosicity '90-DayOralGavage StiunRdatys DuPont-0478 --_ shoving anIinsdailvidduaacla AfnorisailndiLviisdtsienlg anteals DsorsoevrGL( oD S ILe1135Y mmaat/eva/day Sex: Wales perms Wicroncopic & Wacroscopie Findings preven Continued trom previous pede Histopatholony : No MiCLOocRNrDoo,Ss.coSpTWOiENRcAKEGA,Hb,moSrKDmUEOaLDlDEiTNtRGyLH,OMUbSsPCAeLNrECv,ReEdASSP:,LECRO,LONA,ORTSAA,LIVBRAARIYN,GLASNPDISX,AL NSBEASRNOVTDEHI,ABGOELPSAI,RTULIHYTAHARPRHYI GN/OLLDAAEDR,,IYFGP,IANABSNYT,EH(YSRA)ODZRWDEIVTGALHLANOGDLPSAE,NIDCST,RNAECRSVHCEEI,AA,FISCKN, EPPRTODSITDATTHE,IDESSE,MTNFARLIVNESGICELESS,OTUR,INASREYNBNLA.DDEBRO,VEPNEASRTRESO,H, NOSE essa TTEexrpemoivdnaarleonGSaprcaorywif+i+5c5eS0DAY Eat Tae omed 068 trom necropsy Gross ratholony ~ No MFaoOcvNreTonRs,,copEBiRIADcIUNEA,YbSn,oSrPTmIOaNNAlGLiSt)CyOMOREbDAsReErS,vTOeMdSAKCE:HL:ETADLUODMEUNSOCHL,E,IBSTPULNECEMN:, | ONTODERDEEN,H,ALSAPGALLNIACVNRADERSAY,S,GLSACCNICDNUSTM,I,CNANCNEODRLEVOBENU,,LAPRR,RCTTLUOYTMNI,EAHRYMMESOGEDLNEAP,DER:TLCH.USL,MP FSTEIRNRATORLYAD LGVLBAASRNIIDCN;L,ESPS,AVRETART(3DI)NYARWROIETTDBHLGALODAPONTRDIRSC,, NTETRRRVGAERC,SKSE.RS,KSIBS,SISDPEIHRDAOIGSAUTRASEF,SE,, FRRRBS JOINT, SPER, Ho 654521 Continued on the next page .... --_-- Gompany Santzod. Doss ot conTSCaACnBI smoor Geass: mate I oiynS uSrmpnE.,grFos o rn oia .;m o S--._r--i ~ aE E E REememTrEE onT wrTTaEsnDaoIsaigsat oaouyy5mu E Ea ETrRET ~ C 20DDaoyOOulGGuO ovvpetuedyinnyR. toates si pDwureownsois7ss ~ Showing anIinpdailvidduaatla AfnorinailndLiviisdteinnsg anipals Dsotovoer GoM 24615315 mmagt/ekg/day Sex: Males ferme Microscopic & Vacromsopie Findings Grassi TKerirplmoliwenedarlsonGSrapocawry.if+ i+ c1eS75NTEL Taieal To signed off Econ necropsy Gross pathology : No MHaLEcoVrxEoRs,,coSpKiIrDcaNmEA,YbSm,SoPmLIaUNlNAiGLSc,oyrHObEb,AsReTSr,FvOeMdSAKGSHL:ETADLUOBWEONSOCRL:E,TSReLOEENN, ANLODERBEE,i,nES,APGALLNIACVNRADERSAY,S,GLSACCNRIDOASUT,NI,CMANCEONRLDVOIENB,,ULABRREAGTILCORYNR,AMAMYNEGOOOBEAF.DE:RSLEeL,b TSFAREVARTROILID/LVGAELRSAINICDNL,,ESFB,AYREUNR(T8II)NRAOWRIIYDTBHLGALODAPONTRDIRSC,, NESTRRoVArECe,KsE.RS:KISNeE,iSDOIPFSHRTAOMGGEURRSAR,ESE,, FEMR/KES JOIN, STERN, N00 PN ssa37 EKTxeiprlomlsieendraelonGsrpaoacywr.if+ i: c1Se35ATE Aniaal io siomed off fron necropsy Gross pathology + No MaMXOcvNrEToRAs.,copBKiRIADcINNEA,YbSn,SoPmILaNOlANiGLSc)yCOWOREbDAsReESr,TvOeMSdAKCE:HL:ETAYLOWiRscELE,TSSyeocnaa,, ANTODEDREEEN,N,ALSAPGLALINACVNRADERSAY,S,GLSACCNIODNUSTN,A,CMNACEONRLDVOIENB,,VLAPRRREECLONTYI.AMREWNEGoSLbAA.ENAD,LHS.ep,H 654937 Coninied on the next page ... --_ ------T-- oeee ----i ---- CompanySaitzed. Does not contTSaGAiGBnI CS ON yOu TC t St5y:ii nRts e ici wedvymR DDuupoe nnt947n8 supy cco Smheoiweing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group:IX 125 mg/kg/day Sex: Males Animal Ret Microscopic & Macroscopic Findings 654537 Continued trom previous page Gross Pathology : No MaPTcHHrYAoRRsOYcINoDKp/iGLcLAARNAYDbX,n,orPSmAYaRElA(iTStH)yYRWOOIbITsDHerGOvLPAeNTdDISC:,NETRRVAEC,HEAS,KINB,SOPPHRAOGSUTAST,E, FSEEMNUIRN/ALKNVEESSIJCOTLNETS,, SUTRETRNNAURMY, BNLOADSDEER, TESTES, EPIDIDWMIDES, 654042 KTeirlnliendalon sDaacyrif: ic18e3 AEnxipmoaslureisGsriogunped: oRfEfCOfVrom necropsy Gross zathology ~ No MaALOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,oSPrLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETADLUODWEUNSUCML,E, SESSPULNsOaM,, ILEUM, PANCREAS, CECUM, COLON, RECTUM, MESENTERIC vie TANHDODRYEER,NOAILDSAGGLLLIAAVNNADDR,SY, GPLSAACRNIADNTSTH,IYCROMNIAEDNRDVGIELB,AUNLDPASIR,TULTIYRTMAAPCRHHYENAGO,LDAEN,EDS,OTPHHYAMGUUSS,, FSPEEHMNAUIRRNY/AIKL/NLVEAESRSYIJNCOXLI,ENST,,SYEUS(RTSIE)NRAWRNIY,THBNLOOASPDETEIRC, NTEERSVTE,ES,SKIENP,iDIPDRWOMSITDAZTSE,, Histopathology : L1veRNHEY CPREORSPILSA,SIAF,OCABLI,LEmiDnUiCTm,al minimal. 654942 Continued on the next page .... -- mn Company Sanitized. Doosnotcontain TSCA CBI -- wd-- yo berui ToC icty mpS. ubitoa Duwpons esirrs ~ Showing aInntdieviddueacla AfonrtailndiLviisstuien)g aninsls tcrovaeorQE4so1 mmaanvsastey sexs wales ferme sieronsopte & Wancoraopts Fimtings FH Gonmesa trom previous pegs Hiatopathetons wrefn ooemn ------ SE T m ssesst rH Eeerpmoivenaacle eGsuarcpr'if5i+ceS0AY fein S-- Gross Fatholony _ No MaNEcovrreonns,.copSEiIaDcnNSAtYbSn,oSrrTmaaIlNmiSt,CyooJnEb,AsReTSr,vreodSuKRE:GLRETDALOMRUSRCL:E,SSPSLEE:N, rpTomir, oTaoacrhitns, iCocuve, Conon. NBER R. dWrERiVy EyRLS LP TrTEri GCERTEOLESA,iARDAOAi RSY BiAo AebonRR.. BTEbaEESn.a BSReioDPIAo SGNLISS.R! ocd ons Histopathotoy : Lava Conn, ta clan-- mini-- ma 656551 Continued on whe mens pe = _--_-- m -- _----_-- CompanySantzad. Does not contain TSCA GBI CO cc 7 [-- so acs vceriosn TSE SEP I--I--Y reate PT pr Shs meee Soncinaed oon seenionn soon S isesI soseI , smsnsocainas, mite, santiA ssromoeamy, minisiattn, costes. a ra2 iv, inicoonns.er, severe. os Seemed atte ~ A LT Tn foe al Eg airT , spT p agp r I itagea a TIE RR Soma vESicias, uno siainen, res CompanySas. Doss ets T30AG81 COS0DsyOraGavage Sy inRats 70 Duron 9478 ~~ ad CY:551Shmowing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group:Ik 125 ma/kg/day Sex: Males Aninal nef Microscopic & Macroscopic Findings as0os5 KTielrlmeidnalonSDaacryif: ic53e AEnxipnoaslureisGrsoigunped+ oSf0fmAYfrom necropsy Gross pathology : xaoweDyIsLATATION, RIGHT, severe. No MSaLPIcIVrENoRAs,LcoCpLOiORNcDG,SA,tm'SoHTErOAmNRaATlC,Hi,tSyDKUEOOLbDEsETeNArULvMe,MdUJS:CELJEU,NNS,PLELEEN,M,AORPTAAN,CREBRRSA.IN, GSCLCEAICNUNDNT,SI,CCNMOELARONVNDE,I,BU`RLPEAICRTTUULMI,YTMAWPREHYSGNEOLNDATENE,DR.ITCTHHYLMYyURWSOp,IiDANDGoLDRBAE,NNDA,LSAGLLIAVNADRSY, UPERYAEIR(NASAT)RHYYWRBIOLTIAHDDDGOELPRAT,NIDCST,ENSETRTEVRSEA,,CHESSAKP,IIND,ISDSYPONRPIOHDSAETGSAU,TSE,,FRSMSHUEANMR/IYKNNAN/LELEAVRESYSONIEDC,L.ES, -- STERN, HOSE istopacholosy: LaverHIYNPFELRMTMRMOIPIHOYN,, HESUABOACCEULTLE/UCLHARRO,NICm,ildm.inimal. KowEvHCsHYRDOR; NOINCPHSRROOSGIRSE,SSIUNVIELNATEEPRHARLO,PATmHiYn,imamli.nimal. wearerH:YPERTROPHY, TUBULAR, minipal. 654955 Continued onCAtRhDeIOnMeYxOtPApTaHgYe, - aintnal. -- mn `Company Sanilized. Does notcontain TSCA G81 S0-DayOral Gavage SvinyRacts: osc Dupon.9478 -- Individual Aninal Listing Showing aniral data for individual eninals stupy CO: c5: maze Dose Group : 1X 125 mg/kg/day Sex: Males Ania) Ref Microscopic & Macroscopic Findings asi555 Continued fron previous page Histopathology: No MiLUcNrGoSs,copSiKcELAEbTnAoLrWmUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, RLSEYTCMOTPMUAHMC,HN,ODMEED,SUEONTDTHEEYNRWWIS,C, JLEAYJDMURPNEHUNMAN,LODEGI,LLAENWSDHA,SL,IVPASARCIYCIRAETGALISAC,NDNSE`,CRAVCEMU,MA,NDCIOBLUOLNA,R `EPTYIRETA(UCSIH)ETAA,WRIYTEHSGOLPAONHPDAT,GIUCST,NAEYRPRVHOEAI,RDYIGSCLKAKINN/,DL,ARPYRPIOA,SRTAATTHEY,ROISDEAGDLNAANLDSV,ESICLES, USTREIRNNAURNY, BBLAODNDEERM,ARRTOEWS,TESN,OSEBPIDIDYNIDES, FEMUR/KNES JOINT, esass7 TKeirlmliendalonsaDcaryif:ic1e83 -- AEnxipmoaslureioGsriogunped+ oRfEfCOVfron necropsy Gross patholosy Yo MaLIcVrEoRs,copKiIDcNEAYbSn,ormLaUNlGiSt,y OHEbNsReEr,vedSKE:LSTAL MUSCLE, SPLEEN, NAIOOLDREETG,AH,, `SBPARALANIICVNRA,ERAYSS,GPLIACNNEADCLSU,NC,ORWDAC,NOLDOISNBT,OUMLAARCREHC,TLUYMMD,PUOHDMEENNOSUDENEN,,TERJTIAEYCJMUUNLSUY,MM,PH ATBHDHYRARERONYIANDLX/GGLLLAAARNNYDDI,S,, PSEAYCR3IA(NTSTH)IYCRWOIINDETRHVGEOL,PANTDIPSCI,TNUETIRRTVAAECR,HYEAGS,KLIANNE,DS,OPPHRAOGSUTSA,TE, 654557 Continued on'SFREthAUeUIRN/nAeKLxUtEVSEpSIJaCOgILeNETS,, USRTIERNNAURMY, BLNAODSDEER, TESTES, EPIDIDYNIDES, -- EE Company Sanized. Dossnotcontin TSCA Cal ON ayOraY l Gav) age StiunRdatys751 DuPont. 9478 Dsotuspey Gro Showing anIinmdailvidduaatla AfnoirrailndLiviisdtuianlg animals Xc125omge/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings 654957 Continued from previous page Histopathology : LIVERIN: FLAGINTION, SUBACUTE/CHRONIC, minimal. KIDNENYESCR:OSIS, FOCAL, mild. THYROICHDROGNLIACNDPR: OGRESSIVE NEPHROPATHY, minimal. `ALTERATION, COLLOID, mild. No MTiHcYrMoUsSc,opiNcOSAEbnormality Observed : 654962 TKeirlmliendalon SaDcaryif: ic1e75 AEnxipmoaslureis Gsriogunped: SATEL off from necropsy r Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,omLaUlNiGSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULAPRITULIYTMAPRHYNOGDLEA,ND,THYMUS, TPHHYARRVOIIXD/LGALRAYNDN,X, `EPYAERA(TSH)YRWOIITDHGOLPANTDISC,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, PSEEMMUIRN/AKLNEVEESIJCOILNETS,, USTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --~ -_-- T776Company Sanitized. Donotecontsain TSCA CBI -- mr pssonicToity DuPont 9478 --_ stoov [24691Smheonseing anIinmdailvidduaatla AfnoirnaiindLiivsiteiansg animals Dose Group + 2 125 ma/xa/dey Sex: Males Satna net Microscopic & Macroscopic Findings Gases KTeiremisnalonseacyrif+ic59e AEnxipmoaslureiGrsoiugpn.ed+ oSf0fDAYfrom necropsy Gross Pathology ses)Vawsiem,ovrRzIGcHTw:es: No MALaOIcRVrTEoARs,,copBKRiIADcINNEA,YbSn,SoPmILaNUlANiGLSt,yCOROHDEb,AsReTSr,TvOeUSdAKCE:HL,STDALUOMDUSECNLLE, TSePsLtme,, ANIODLDBREUE,NN,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUR,MI,CNANCENORLDVOIENS,,SLAPRREICTTLUUYIMNT,EAHRYNMEOGSDELEMA.TDS.hSunaLnob -- EsBTRLHsYAsARDOETIRD,LGATLREASYNTDCE,,S,PSABKRIRANIT,SHTYOPRWRONOIISDOTRAGSTL,EA,NDFSSR,EUNRTT/RNAAKCLEHEEVNE.SSToOBReSSO,RP.HSAGVUrRSS,nIAaRY ststopathotony : LavenAIYNPFERLIARTOIRROYN,, HESEUBNNTCOUCTEEL/LCIHARRO,NTCm,ilam.inimal. KooCNsHERCORONSIICS,SROFOGCRAELS,SIVmEiniNmEaPlH:ROPATHY, minimal. THYROATSLDYTEEGSRLRAATTNRIDOORN,Y, COTLULBOUILDA,R, momdienraatle,. 654965 Continued on the next page. - Company Sanitized. Doss not contain TSCA Gel CO50MDay Tidy in Ratic Toc Dupont9478 --_ groveCoacs z mShioweing anIinmdailvidGuaatla AfnoirmailndLiivsitdiunag animals Dose GAPIL 125 mo/kg/day Sex: Males minal nef Microscopic & Macroscopic Findings Suse Continued from previous pave Histopathology : Eve(s)OPwTImCaNEoRpVErNOneTwvPeRES:ENT. woss DEGENERATION, AVELOBLASTS, mild. No Mi"CLOcURrNDoG.sS,coSpTHiOEcMARADCA,Hb,noSrKDUEmGLaDElETiNAtULyN,MOUbSJsCBeLSrEUv,NeCdNS,P:LETELNE,GH,AORPTAAN,CRESARSA,LN,CCSUPMI,NAL NSCEAORLNVODENT,,SULRPABXRCTTUOLIMXT,UAPRHYWEGNSOLEDANENT,DZ,RITCPHAIYRNNSH,HYRAODNLRODDEEN,AGLLASNGADLLSAI,NVDASTR,RYACGSKLCEAIRNA.DTSZ,C EESRPSOTOSDRTIAADGTIUENS,I,DESSPH,IRNAFARRLIM/OVLREKASNIRECALSKE,SJ,OBINYUTER,I(N9)SATREWYRINTBCLHHA,DODPETBRIO,CVETNEMESRATVREER,SO,WSKIN, ~~ 654973 ATKEnxeiiprlmomlasielundraeliosnGSsbraiacogyrunipef::dic1Aoe8f3BfCOVfrom necropsy Gross Pathology Yo MaIHOcVRrRToAs,.copIBiRNAcIENAS,bn,oGrFmILUaNNAlGLiSt,CyORHODbE,sAeTrS,TvOeWdSAKCE:HL,ETDAULODWEUNSTCNL,E, JSEPNLIEENN,, NHIOLODEEOR,N,ESAEGLALNIACVNRADERSAY,S,GLSACCNBIDOASUT,NI,CWNACEONRLDVOIENB,,ULAPRREICTTLUUYIMTM,APRHYMENGOSDLEEAN,NTDE.RTIOCiGLSY,MPH 654973 Continued on the next page... -- _-- Company Sanitaed. Donotecontsain TSCA GBI - so (cies TE BTaITTrE ToTmmeo,smom,a "-oE Fa yOREEETT ~ W--sit--so--n--g-- ~ -179- Semen C 0D OO ral GaN vage StdyE in Ratisc7Y 55 Dupont9478 -- stoy Occ Sehaoweing anIinndailvidduaatla AfnoirmailndLiviisdtuianlg sninals Dose Group + Gk 125 mo/ka/day Sex: Males Aninal Ref Microscopic & Macroscopic Findings G47 TKeirlmliendalonSaDcaryif:ic16e3 AEnxipmoaslureisGrsoiugnped: RofEfCOVfrom necropsy , Gross pathology : No MAaLOIcRVrTEoARs,,copKBiRIAcDINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyORHODbE,sReRrS,vTOeWdSAKCE:HL,ETADLUODWEUVSDCML,E,JESIPULNEOEMN,, NAIODLDREEEU,MN,ALSAPGLALINACVNRADERSAY,S,GSLACCNIEDCASUTN,I,CMNACEONRLDVOIENB,,ULAPRREICTTLUUYIMTM,APRHYVENGOSLDESAN,NFDE,RTIHOUSLi,ch TPSHHEAYMRRIYONIIAKDL/LVGAELRSAYINNCDLK,E,SP,EAYREUA(RTSIH)NYARWROIYITDHBLGALODAPDNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISODPSIHRDAOWGSIUTOASET,SE,, FENUR/KNES JOINT, STERN, NOSE -- Histopathology : LrvenNIENCFRLOASMIOST,IOFNO,CALS,UBmAiCnUiTmEa/lC.HRONIC, minimal. xioweHsYPERPLASIA, BILE DUCT. minimal THYROHICYDHDRRGOLONANINECDP.HPRROOSGTRSE,SSIBVILEATNEERPAHLR,OPAmTiInYi,alm.ininal. ALTERATION, COLLOTD, minimal. No MiTcHrOoSsc,opiNcoseAtmormality Observed : -- --_--_-- TR CompanySanized. DoesnotcontainTSCA CBI CR 5: ici X 90-Day DOralyGavaO geStum dyin i Rats Ceagsdud00yinRpDuuPeonet-9ss478 --~ Showing anIinndailvidduaatla faonrimailndiLviisdtuianlg animals sDooseyGr(oupJ* aTxs125smnaa1t/eko/day Sex: Males Animal Ref Microscopie & Macroscopic Findings ure KTielrlmiendalonSabcayrif+ic1e63 AEnxipmoaslureisGsriogunped: oAfBfCOVfrom necropsy Gross Pathology Yo MLAaIOcVRrEToRAs,,copKBRiIADcINNEA,YbSn,SoPmILaNUlNAiGLSt,CyORHODEb,sAeRSr,TvOeMSdAKCE:HL,ETDAULODMEUISNCGLN,E,JSEPOLNEEGN,, NAIODLDEREUE,NN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCNSUT,NI,CMACNEONRLDVOIENB,,ULARPREICTTULUIYMTM,APHRMYENGOSDLEEAN,NTDE,RTIHVCiCLSY,MPH TPSHHEAYNRRDYOUNIAKDL/LGVALERASYNINDC,EL,ESP,EAYREUA(RTSIH)NYARWROIYITDSHLGALODAPDNTEDIRSC,, NTETERRSVATSC,EHSE,AS,KIBNPE,ISODPPIHRYAOMGSIUTDSAE,TSE,, FEMUR/RNER JOINT, STERNM, NOSE P ststopathology: LaveN"EICNRFOLSIAST,IOFNO,CALS,UBmMiCnUiTmEa/lCHRONIC, minimal. KaoueyCsHRO;NIC PROGRESSIVE HYROD GLAND NEPHROPATHY, mininal. wose DAEUGTEENREARTAIOTNI,ON,COALLMOEILDO,BLAmSiTnSi,malm.ininal. Yo Mi`cmraonsscopic Abnormality Observed : esses ------E--on---------------------- Company Saniized. Doesnot contTSaCAiCnB O 0-DayR OraGa) vageStuds y in Rc ats oxicey . Dupont9478 --~ Showing anIinrdailvidduaatla AfnoirmailndLiivsitdiunagl animals sDmoospey Gra oup : : IXcs1s2:5 nmaa/kg/day Sex: ales Animal Ref Microscopic & Macroscopic Findings 654977 TKeirlmliendalon SaDcaryif: ic1e83 nExipnoaslureisGrsoiugnped: oRfEfCOfVrom necropsy Gross pathology KoowEyCsALCULDS\CALCULY, RIGHT. Yo MaSLIcPVIrENoRAs,LcoCpLOiURNcDG,SA,bnSToHOErMAmARaCTlH,i,tSyDKUOEObLDsEEeTNArULvMe,MdUSJ:CELJEU,NUMS,PLEIELNE,UM,AORPTAAN,CREBARSA,IN, CGELCAUNMD,S, CMOLAONND,IBURLEACTRUML,YMMPEHSENONDTEE,RITCHYLWYUWSP,H NAODDREE,NALSAGLLIAVNADRSY, SPCAIRNATTIHCYRNOEIRDVEG,LANPDIST,UITTRAARCYHEGAL,ANDE,SOPTHHAYGRUOSI,D PGLHAANRDY,I/LARYIX, UERYEI(NSA)RYWIBTLAHDDOEPRT,ICTENSETREVSE,, ESKPIIND,IDYPMRIODSETSA,TE,FEMSUERM/IKNANLEEVEJSOIINCTL,ES, ~~ STERNUM, NOSE Histopathology : LIvemINFLAMMATION, SUBACUTE/CHRONIC, minimal. NHEYCPREORSPILSA,SIAF,OCABLI,LEmiDUnCiTm,al.minimal KIDNEYHSYPERPLASIA, TRANSITIONAL CELL, minimal. THYROHIYDDRGOLNAENPDHR:OSIS, UNILATERAL, minimal. 654577 Continued onALtThEeRAnTeIxOtN,pagCeOLLO.I..D., minimal. - =. CompanySanitized. Does notcontainTSCA CBI C50-DO ayOr . Gavage. Stian. Rayte Toxicity DuPont 9478 ~ stor (24601/Smhaotweing anIinndailvidduaatla Afnoirmailndiivsitsienags animals Dose Group : IX 125 mg/kg/day Sex: Males Animal ne Microscopic & Macroscopic Findings Gir Continued from previows page Atstopathology Ho Mi"cmraossc,opoicssAbmomality observed ssasns TKeirlmliendalonsDaacyrif: i1c8e3 AEnxipmoaslureisGrsoigunped+ oRfEfCOfVrom necropsy Gross pathology : No MAaLIOLIcREVrTGEoAHRs.,,coPBpKRAiIANDcDCNYREA,EYbASnS,So,PrILmCNUaNAlBGLiCSt,Cy,ORHODCEb,OAsLNeOESrN,Tv,OeMdSARKCEE:HCL,FEOTNDA,LUONMEUBSSECBLM.ET,ERTLSeSersseoi,a ~ TNABHODHDYRAERER,ONIIA/DLSLAAGGLLRLIAYVANAYDDRXS,Y,, PGTASLYREAENIA(DNTSSTH),IYCRWOWINIATEDNRHDVGIEOLB,PAUTNLDIAPSCRI,TNLOETYIRRIMVAAPECRH:KYENRSog.sKrsna.S.pe.SmPPvHaiAsGosUsSe,r, FSEENNUIRN/AKLIEVEESIGCOLIENST,, USRTIENRANRY, BHLAODSDEER, TESTES. Bbioimvirers, Histopathology : LavenHIYNPFERLPALTAISIOAN,, `BSiULBBADCUUCTTE./CmHiROnNiImCa,l.minimal. 654575 ContinueTdHYoRnO'AILDtThEeGRLAnATeIxDOt:N,pagCeO.LLOTD, minimal. ~ _-- Company Sanitized. Dossnotcontain TSCA CBI CO9MM0ODraaGavyageSudy inRts 7x1 Duport478 -- Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals DsotsoeovGr:(ogugpggglClKas1e2s5i/mnaa/tkea/dsy Sex: Males Animal Ret 550578 Microscopic & Macroscopic Findings Continued from previous page Histopathology : No MiKIcDrNoEsYcSo,picTHYAMbUnSo,maNlOiStEy Observed : ss47 TKeirlmliendalonsDaacyrif: ic53e AEnxipmoaslureisGrsoigunped: oSf0fDAYfrom necropsy Gross Pathology Yo MAaLOIcRVrTEoARs,,copKBiRIADcINNEA,YbSo,SmPaLIUNlNAiGLtS,yCORHODEb,AsReTSr,TvOeWSdAKCE:HL,ETADLUODMEUNSUCML,E, JESTPULNEOEMN,, ~ ANTDOUDREEUE,NN,ALSAPGLALINACVNRADERSAY,S,GLSACCNEIDCASUT,NI,CMNACEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRMYENGOSLDEAENN,TDE,RTIHYCMULSY.MPH TPSHHEAYNRRIVONIIAODLU/VGLELASARINYCDNL,KE,SP,SAVREUA(RTSIH)NYARRWOYIIDTBHLGAOLDPADNTEDIRSC,, NETTRERVSAETC,EHSE,AS,KIENPE,ISDOIPPDHRYAONGSIUTOSAE,TSE,. FENUR/KNE JOINT, STERNUM, NOSE ststopatholosy LovesHDYNPFELRATIRNOTPIHOYN,, HESPUMBTAOCCUETLEL/UCLHARR.O,NICm,inimmianli.nal. xapwePsIGMENT, TUBULAR, minimal. 654579 Continued onHYtPhEeRTnReOxPtHYp,ageT.U.B.ULAR, minimal. --~ --_-- Company Sanitzed. Dossnot conTtSCaAiGBnI C 50.Day OrO al Gavage SR tudy in Rats) ic Tovicity Dupont9478 -- Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals Dsotosoev_Gr{oluap:seIsX11/25namgt/ekg/day Sex: Males antral Ref Microscopic & Macroscopic Findings 650975 Continued fron previous page Histopathology : KaoCsHRO+NIC PROGRESSIVE NEPHROPATHY, minimal. maneCARDIONYOPATEY, minimal. THYRO`IADLTGELRAANTDION:, COLLOID, minimal. Yo MLiUcNrGoSs,copSiKcELAEbTnAoLrWmUaSlCiLtEy, ObSPsLeErEvNe,d A:ORTA, BRAIN, SPINAL CORD, RSETCOTWOANC,H, `MDEUSOEDNETNEURNI,C LJEYJMUPNHUMN,ODEI,LEUSMA,LIVPAARNYCREGALSA,NDSC,ECUMMA,NDICBOLUOLNA,R LPYIUTPUHITNAORDYE,GLATNHD,WSP,ARAADTRHEYNRAOLIDGLGALNADNDSS,. STCRIAACTHIECA,NERBVSEO,PHAGUS, SPEHMAIRNVAVL/LVEASRIYCIL,ES,EYEU(RSI)NAWRIYTHBLAODPDTEIRC, NETREVSET,ES,SKIENP,IDIPDRYONSITDAETSE,, ~ FEMUR/KNEE JOINT, STERNOM, BONE NARROW, NOSE suse KTeirlmliendalon SDaacyrif: ic1e75 AEnxipmoaslureisGsriogunped: oSfAfTELfrom necropsy Gross Pathology No MaLIcVrEoRs,copKiIcDNEAYbSn,orLmUaNlGiSt,y HOEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TOMD,UODWEENSOEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMNAENRDVIEB,ULPAIRTULIYTNAPHRYNOGDLEA,ND,THYMUS, 654962 Continued on the next page -... -- = -- Company Saniized. DossnotcontainTSCA CBI CR50.DayOral GavageSodyin Rtis sc Dupon9078 ~ Showing anIinndailvidduaatla fAonripailndiLviisdtuianlg anirals DsotsoerG{rgouupl:)2IuX619215 mmaat/eko/day Sex: Males Aninal Ref Microscopic & Macroscopic Findings asess2 Continued fron previous page Gross pathology Ho MaPTcHEYrARoROsIIcNDoEp/GiLcLAANARDbN,n,orPEmAYaRElA(iTStH)yYRWOOIIbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSTRAIIUNRA/LKIVEEESIJCOLIENST,, USTREIRNNAURMY, BNLAODSDEER, T8STES, BeiDIDMEDES, sses83 EKTxieplrolnsieundraelonGSraDocaurypif: i: c93e90DAY Animal is signed off from necropsy Gross Pathology ETresrtoersSoUNAILDL,ESUN ILATERAL. ~ SHALL, UNILATERAL. No MAaLOIcRVrTEoARs,,copBKRIiADcINNEA,YbSn,oSrPmILaNUNAlGLiSt,CyORHODEb,AsReESr,TvOeMSdAKCE:HL,ETDAULODMEUNSGCHL,E,JESIPOLNECEMN,, ANIDOLDREEEU,MS,ALSAPGLALINAVCNRADERSAY,S,GLSACCNIEDCASUT,NI,CMNACEONRLDVOIENB,.ULPARIRETCTULUIIMTN,APRHYMENOGSDLEEAN,NTDE:TRIHCisL,ib SPTEHHNAYDRRNIOAIILK'D/LVGAELRSAYINNCDEL,,ESP,BAYRBUA(RTSIH)NYARWROIYITDBHLGALODAPDNTEDIRSC,, NEFTRREVAMECU,KRE/RKS,NKIENEE.SGOOPPHRTAOTGS,UPSR,EE, 654983 Continued onstthemn,extvpoasge -... - = Company Santzed. Does not contain TSCA Cal C 90.DayOR ral GavaT geStudy) in Rtis Toxic Dupont9478 --_ Showing anIinmdailviddautaal AfnoirmailndBiivsitdiunag animals DsotsoevvGr-(oupuSgIX216259nmaat1/eka/day Sex: Males Animal Ref Nicroscopic & Macroscopic Findings 656563 Continued from previous page Histopathology : LaverHIYNPFERLTARTOIPHOYN,, HESPUABTAOCCUETLEL/UCLHARRO,NTCm,inimmianli.mal. sKeoonwseHyYsxPE+RTROPHY, TUBULAR, minimal. warINFLATION, SUBACUTE/CHRONIC, minimal THYROICDARGDILOANNYDOP+ATHY, minimal TastesALT|ERATION, COLLOID, minimal. sexommDooEidGIeEDrNEaEtsReA.T;ION/ATROPHY, SEHINIFEROUS TUBULES, UNILATERAL, --~ OLIGOSPERYIA/GER CELL DEBRIS, UNILATERAL, severe. No MSiSTcKOrEMLoAEsCTcHAo,LpiDMcUUOSADCmELoNSUm,Ma,SlPiJLtEEyJNU,NOUbMAs,OeRrTIvALe,EdCHA:,RAPNA,NCRSEPAISN,ALCoCOOTRMD,, COLON, PLRIYETCMTUPOIHNT,ANRODY'EY,EGSLEATNNHTDYE,NRUISCP,ARLAAYDTMRHPEYHNRAONLOIDDEG,LGALNASDNASDL,SI,VSATRCRYIARCGIHLECAAN,DNSE,REVSEOM.PAHAADGSUBSO,LAG SSPTHEAENRRIVNNIUAOHLU,/LVEOASNRIECAL,EMSA,RBRYOUEW(R,SI)NNAOWRSIYETHBLAODPDTEIRC, NESREVMEO,R/RSNKIENS,JPTRSOS.TATE, -- --TT TTT T Company Sanitzed.Doss not conTtSaCAiCnBI O5O0.DsyOrsGav St}y inRaic 7xicity Dupons 9478 --_ Individual animal Listing Showing animal data for ndividuny animals DsooseoGr(owIRIE24515215/mmaal/eka/dey Sex: Males Saint Ref Microscopic & Macroscopic Findings pres SKTxeiprlmolisenudacleonGsrabocaurypif+ ic1R0e3ECOV Final Ts sigmes off From necropey Gross Patholosy Wo MaHLOIcRVrTEoARs,,copSKRiIADcTNHEA,YbSn,oSreLImUNaNAlGLiSt)CyORWODEb,AsReTrS,vEOeNdSNKC:EAL,TADLIOMUDSECL,E, JESPTLOENEMN,, RNTOOLDREEE,N,ALSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCNSOF,NI,CMANCENORLDVOIENB,,ULAPRREICTTLUUYIMMT,PAHRMYENOSGDELENA,TDE:RTIRCVWLS,PH SETRREAURMRTOIILONLD AVGLERASNITDC,L,ESP,SAYREUA(RTSHI)YARRWOYIITDHBLGALODAPDNTEDIRSC,,NETTRERVSAETC,EKSE,RS,KIENBP,SIODPFIHROAOMGSIUTDSAE,ISE,, FERKgs J0NT, STERN, NOSE -- Histopathology xLaaveonIsN:FLATION, SURMCUTE/CHRONIC, minimal. THiRoARCUDvTstSG,RLAATmIDiOnNi,malCOLLOID, minisal. oss ICrNoFmLoApyTsIEOLNA,SIAS,UBmNoCdUeTrEa/tCeH.RONIC, mild. o Mincrosscopic Abnormality Observed : --_ = --_-- Company Sanitzsd. Doesnot canainTSCA GBI C 9D0DD O Oraly GR avago eSY tudu yin) RcG aiscTuoicta y geSudyinRoDwue opwonos 4s7s6 rr Showing anIinrdailviddautaal AfnoirmailndiLviisdtuianlg animals sDotsoerGr(ogwfp)zaI6X 9112/5mmagt/eka/day Sex: Males Animal Ref Wicroscopic & acroscopic Findings aaa TKeirlmliendalonsbaacyrif: ic93e AEnxipmoaslureiaGrsoigunped o0fDfAYfrom necropsy Gross rathology : Yo MAaLOIcRVrTEoARs,,coBpKRiIADcTNNEA,YbSn,SoPrLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSGCML,S,JESPILUENENN,, ANIDOLDREEEU,MN,A'LSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCNSOT,MI,CMANCENORLDVOIENB,.ULARPREICTTLUUIiMT,ApRYMNEOGSDLEEAN,NTDE,RTIHYCMULS,F TSDEHHMYAIRRNOYAIILD/LGVAELRSAYINNCDKL,E,SP,YAERUA(RTSIH)NYARWROIYITDBHLGALODAPDNTEDIRSC,, NTETERRSVATECE,HSE,AS,KIENPB,ISODPSIHRDAOMGSIUTDASET,SE,, FENUR/RNES JOINT, STERN, NOSE Histopathology : ~ LemHY PERTROPHY, xaowzys HEPATOCELLULAR, mild. THYROIHCDYHPREGOLRNATINRCDO.PPHRYO,GRTEUSBSUILVAER,NEmPiHnRiOmPaAlT.HY, minimal wos `AUTSRATION, COLLOID, mild. DEGENERATION, AMELOBLASTS, mild. 654986 Continued on the nex page .... -_-- ee Company Saritzed.DossnotcontTSaCAiCnal CO90.DayOralGavage Syin Ratisc oi Dupo 0478 -- Showing anIinmdailvidduaatla AfnoirmailndLiivsitdiunagl aninals stor (iaso1male Dose Group : IX 125 mg/kg/day Sex: Males Animal Ret Microscopic & Macroscopic Findings pre Continued fron previous page Histopathology: No MiLUcNrGoSs,copHiEAcRTA,moSrKmEaLlEiTtALy MOUbSsCeLrEv,edSP:LEEN, AORTA, SRATN, SPINAL CCOOLRODN,, SRTEOCMTAUCMH,, WDUEOSDEENNTUEMR,ICJELUYUMNPUHN,NODIEL,EGHS,ALIPVRACRRYEAGSL,ANDCSE,CUN, NYEARDVEI,ULPAIRTUILTYAPRHY NGOLDAEN,D, TPHAORUNST,HYARDORTEDNAGLLANGDLSA,NDST,RACSHCEIRA,TIC PESROOPSHTAAGTUES,, 'SPEHMAIRNYANLE/VLEASRIYCNLEE,S, EYUER(ISN)ARWYITBHLADODPETRI,C TNEESRTVEES,, SKIN, EPIDIDVNIDES, FENUR/KNES JOINT, STERNUM, BONE MARROW ases90 TKeirlmliendalonSDaacyrif:ic1e63 AEnxipmoaslureisGrsoiugnped: oRfEfCOVfram necropsy ~ Gross rathology : Yo MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HObEsReRr,vedSKELETAL WUSCLE, SPLEEN, AIOLRETUAM,, PBRAANICNR,EASS,PICNEACLUNC,ORDC,OLOSNT,OMARCEHC,TOMD,UODMEENSUEMN,FERJIECJUNLUPM,H ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICWNAENRDVIEB,ULAPRITLUYITMAPRHYNGODLEA,D.THYMUS, PTEHAYRRYOIIKD/LGALRAYNND,X, PEAVREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS.KINE,SOPPHRAOGSUTSA,TE, FSEENNIUNRA/LKNVEESIJCOLIENST,, USTREIRNNAURMY, BNLOASDEER, TESTES, EPIDIDYIDES, 654590 Continued on the next page... --- Company Sanitzed. Doesnot contain TSCA Call O N 50.DryD Or yR GvageOtu iny. RasG0u c getubyinpRoDe usPonets 97s8 ~ Showing antinmdailvidGuaatla AfnoirmailndLiviisdtuiansg annals DsooserGroupglaxc1e25rmi/sxg/dey Sex: Wales Sainal nef Microscopic & Macroscopic Findings ssuss0 [Sp ---------- atscopathology : LavenN`EECLRRODSIAST,IOSNO,CASLU,SAmCiUnTiSm/aClH.RONIC, mininal. KooCEsHYRPOE|NRIFCLASPIRAO,GREBSISLIEVEOUCNTE,PHRmOiPnAiTzHaYl,. minimal. THRAOUTSGRLAATNIDON, COLLOID, moderate. Yo N"icmzrossc,opNicotAbmemality Observed : ssesor EKTxeiprlomlsieundraelonGsraDocaurypif:i+c1eR83ECOV --_ Animal is signed off from necropsy Gross Fathotony Yo MHLaOIcRVrTEoARs,,copBKRiIAcDINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORHODEb,AsReTSr,TvOeWSdAKCE:HL:ETDALUOMDUESNCILNE,TSrPtLREEAN,, RNIOLODE,,RSAPLGALTNACVNRADERSAY,S,GSLACCNIEDACSEH,I,CMANCEDORLIVOSENU,.LARPR.EICTTUYUIMPT,ANRNYENGOSOELRNA,FNEDRmIAvCHOLLLy SETERAMYIRRNOALSLD/VGLELASARINYCDYL,,ESE,EAYRU2N(RD8IA)NIARWROIYITDBHLGALODAPDNTEDIRSC,, NTETERRVSAETC,EHSE,RS,KISNEP,SDOIPEHDRAOMGSIUTSDA,RSE,, 656591 Continued onFcRheRnKeoxetnpJaogem.,..STERN, NOSE -- e --t --o ----eee En ece im-- i-- m Company Sanitzed. Doss not contain TSGA GBI CO2M0 DayOra Cove sinyacx sity DuPone 478 ~ stove -QEE)245Shm9oatw1aing anIinmdailvidduaatla AfnoirmailndiLviisdteisnsg aninals Dose Group UI 125 mo/kg/asy Sex: Hales Fain ne Wicroscopic & Macroscopic Findings Sassi Continued from previous page Histopathology : -- LavenINPLAGINTION, SUBACUTE/CHRONIC, mininal. moYROATCUHDTAEGGRILAIATCNIDOBNR,OGCROELSLSOIIVDE, NmEiFlHaR.ORATHY, mininal. No MiTcRroSsc,opRiocseAbnormality Observed : ssass6 EFTxeiprlomlnieundzaelonGsrbaoacurypif: i+ c53e300AY Anieal ia signed off from necropsy PN Gross pathology + No MAILaLIOcEVrRUEoTNRsA],copTKSRiRIANDcTCNNREA,EYbASnS,So,PrLLmCW0aENAlCGLiUStM,Cy,ORHoDCEb,OAsLNeOESrN,Tv,OeMSdARKCEO:HLT,EOTDA,ULODMMEEUSNSEGCNHLF:EE,RICmSSp.voLrLeeomRm,,b PTANHDORDYRAERER,ONIIAKDLS/ALGGLLALIAAKVNNAIDDRN,SY,, PGBSLAYACRENI(MDNSSHT),IICRWMONAEDENTRDVGIELOB,APUNTLDIAPSCXR,TNULETIRYRTVAAMECR,KYEnRSGo.KpoI,haB.S:SPBHaAbGrGUhSt,E, FSEEMUDRO/RTVEESIJCOLIENS,, USRTIENRANRY, BoLAoDnDER, TESTES, SMADIOVMIALE, 631596 Continued on the next page ... PS _-- CompanySanitze Doss notcontTaSAiCBnI 2DyyDaOyOunllOnmCpaveaRStudSuiybncihRnutoRnsisc0 Toxicity oDwupoown9o4s78s . grove CO 0co1 mShioweing anIinrdailvidduaatla AfnoirmailndLiviisdtuisnlg animals Dose Group : 125 mg/kg/day Sex: Males Animal Ref Microscopic & Macroscopic Findings pr Continued from previous page Histopathology LaveHIYNPFELRATMRMOAPTHIYO,N, HESPUABTAOCCUETLSL/UCLHARRO,NTCm,ildm.ininal. xaoneFCyYHsPREORNTIRCOPPRRYO,GRTEUSBSOILVAER,NEPmHiRnOimPaAlT.HY, minimal. TsHaYrReOCIDARGDLIAOMYDOP+ATHY, minimal. PARATAHLYTREORIADTIGOLNA,NDSCOLLOID, minimal. wos DYEoG?ENPERREASTEINOTN., AMELOBLASTS, mild. -- No MiLSUTcNOrGMoSAs,CcHo,SpKiEDeULOEADTbEAnNLoUrMMm,UaSlCJiLEtEJy,UNOUSbMPs,LeErEvINLe,EdUMA:,ORTPAA,NCRSERAASI,N,CBSCPUIMN,ALCoCnOoRnD,, RPLEIICTBTURUINT,ANORDY'EW,EGSLEATNNHTDYE,MRUISTC,RALCAYHDMERPAEH,NANBLODSEGO,LPAANSGDAUSLS,I,VASRCPYIHAATGRIILCNaGND/ESLRAVREMG.AX,DYSOLA USERYTSIE(NRSA)RMY,WIBOLTAHNDEDOEPRNT,IACRTREONSWETREVSE,, SEKPIIND,IOVPMRIODSEFSA,TS,FEMSUER/MIN:EEVESSorIvCeL.ES, Ps Ee CompanySaritzad. Doos not containTSCA CBI 90 -- DayOral) Gavag. eStud. y inRatrsonic Toxicity DuPont.9478 Showing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals DsotsoerGr(ouRp :yI2X4619215mmagl/ekg/day Sex: Males Animal Ref 655003 Microscopic & Macroscopic Findings TKeirlmliendalonSaDcaryi:fic9e3 AEnxpiomsaulre'isGrsoigunped: S0DAY off from necropsy Gross Pathology No MaLIcVrEoRs,copKiIDcNEAYbSn,orLmUaNlGiSt,y Observed : HEART, SKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANDODREE,NAL`SAGLLIAVNADRSY, GSLACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPHRYNOGDLEA,ND,THYMUS, `PTHHAYRRYONIXD/LGALRAYNDN,K, `EPYAERA(TSH)YRWOIITDHGLOAPNTDISC, NETRRVAEC,HEAS,KINE,SOPPHRAOGSUTSA,TE, FSEEVMUIRN/AKLNVEEESIJCOLIENST,, SUTREIRNNAURMY, BNLAODSDEER, TESTES, EPIDIDYMIDES, --_~ Histopathology LIVERF:ATTY CHANGE, CENTRTLOBULAR, minimal. HIYNPFELRATIRQOAPTHIYO,N, HESPUABTAOCCUETLEL/UCLHARRO,NICm,inimmianli.mal. KIDNEHYYSPE:RTROPHY, TUBULAR, minimal. No MiLUcNrGoSs,copHiEAcRTA,bnoSrKErLaElTiAtLy Observed : MUSCLE, SPLEEN, AORTA, BRAIN, SPINAL CCOOLRODN,, "SRTEOCMTAUCMH,, DMUEOSDEENNTUEMR,ICJELJYUMNPUHM,NODIEL,EUNS,ALIPVANACRRYEAGSL,ANDCSE,CUM, NMEARNVDEI,BULPAIRTULIYTMAPRHY GNLOADNE,D, THTYHMYURSO,IDADGLRAENNDA,L GPLAARNADTSH,YROSICDTAGTLIACNDS, 655003 Continued on the next page .... --~ 04 CompanySanitized. Does notcontainTSCA CBI CDO eyORe)iseionc Toiciy Dns -- PONT onsossttioonn. yAgin5 BiptingSO PoormveoyG(r26TE61350mme1anfasday sex: wales fee Siemessoria 3 Tasteransta Fontes sions Continued tron previous pave stosepalnotngy + Ho MieEca3rc5ons)icnoyHpEiRcsAAobOFnrIoYrCmaaNlEiRtSVyE,OobsSekriAvnedG,S TATE, SmiTAL VESicrEs, CRANKY BLADDER, TESTReESs, BRTRADSRR Foe mont ~ --------------e5---------------- CompanySanlized. Doss notcontain TSCA Cal CM ORDeyDOlCoy vi SOy nd cRitecoTim c gsedyinkwDeeunpos es _ stooy GY24651)Shtoowming anPimalTdata for indi--eis--ess aninals Dose Group + 11 0 ao/xg/day Sex: Peasies presen Wireman s asroscepis Finiin Ssso0s eEKrripaloiemnraelonGSraboesuyepi.t+ io1R6e3COV Anal Se eines ot rom necropey Gross rathotogy 40 NAaILOIcLRVzTEEoARs,,,copPBKRiRIAIeDICNNREA,EYtnSmS,So,PmLIaCINlNARiGLOStN,Cy,onNodCEb,OAmLReOTSrN,Tv,OeMSdARKCEE:HLC,EUTRBA.LUOMMHUEESSCNBL.MEF,ETRsShevapem,o ETARNOHODREER,O,LSAACGLLILRAVANIADRDS,Y, PGBLASAURCNIARDNTGSTI),EICRWOWINIETDARHVGDELO,APINTESABSCi,rNTeESYRRMeaOPRAEHR,aYEhSaoRmiKeS,aomaPBHeAGeUSn, SGLAENDR(FBEMASLEO)T, ,GVASRTIEESR,N.OFEnRUoS, ThA, SR mates, siatopatholony ~ LaverWIiNcFRoLsAzTsI,ONso,ckSsU,BAmCinUiTmEalC.HRONIC, mininal. o Miocvreosrcsopic Amommality cbserved "~ _-- Company Saniized Doss ot contTSaCAiCBnI S WDeyOoa Cay ves tc oy mn n o cywgSuyinkpa Dwurnonss sur --_ stom (NMa651Scheonwing anIinmdailviddautaal AfnorimailndiLviisdteien)g animals EE Animal ret Wicroscopic & Wacroseopie Findings preven eRBxripmoeindnier]eonGSrahoceurypi.f1i+5cRe8ECOV Final 1s signed off from necropsy Gross patholony No MAaLOIcRVrTEoARs,,coBpKiIRDcINNEA,YbSn,oSrPImLNOaANlGLiSt,CyoWorbE,sAeNSr,TvOeMdSAKCE+HL:ETBALOWUOSCSLE,TseeLaemr, NATIODHLDRREEEO,N,IADLSAPGGALLNILACVANRANDERD,AYSS,GPALRSAGCANRITDONHSITY,NIR,CONINCADEO.DRLIVOGBENLU,,ALNDAPRSREE,FCTOLOTXVNATM,RAHGRHEMERENGoG.EpLNeAF,BSEER:SSSPEtH.AaGLDnSu,b SEHGEALARNNVDI/GA(/FELISNAASLREo),e, ,EGVUEASR(rI3E)aSm,WI,TUHTEHRoOUsPSsT,ICVANGEIRNVAE,, DSKRIEnA:RYamSseanntces, --_ Histopathology : ave p----CA--HrROrNICcunPvRoOsG,RESwSeIoVtEaNNECPuHgRrTO.PATmHiYa,. mininal. sssots TKEeiprlomluieyndraslonGsrbaocaurpyi.:fi+ c5aeSUCAY Final Ts signed off Erom necropsy Gross Pathology : 655016 ContinuewdenonnLtahcee.ext page .... --~ --- CompanySaitzed.Does notcontTSaCAiCEn C DeO Oe Meei) : ici Dosis ~ Fr Shaving anIinmdailviddoutasl aSnoioneta iTsEtiYng pntmats Sore cio 05 mppvarday Sex: remstes riot wai [Pe ------ owris [rm -- J-- Yo sLEEaRciArNvoEeRs,ncSo.pKSiiocouCmmaAarbceno:oo,rrTmCoyanoleiusStn,yh,oeomAbeesree,nrvrmsed oie:usmcaus,nospeeils,, hAToOLwAE,.. SALT GiASDS, Sto en SEL LE NODE, Ga EPUeRAe)sN.tOnStaOGsPA.EDA,NGEH,.ATThSEpaDmil,as'eFAR(RRFCTARS ESR)L. tstopathotosy : -- srvenEve NwenCcicon,, TsmcuTmSCciOmNanEie,,mmiinnsisat. Yo MEEiCRciRrNvoRIesEcenoS,Sp,teCeCaoaAnntbsom,nCo,roTmnCEasAtoRiuSSt.ynhokouAebnsveeeenrevrnoesd na u-scausp ,EseEt is,, AOToNnLTmEn.., ECESIAABER(L5NAR)TRRYeoStrLCnDDAGSRSEiSR,nLeNso ,NeeFoanRhpeoeykaiSSreSeeeclhppoeDo::y:AOTTRROESOY,DAROJSILDoSDEnE., CSiane,s SSoTmRe.sponaRntsen a CLAD.(PEL --~ GompanyStand. oss ratcataTSCAGBI D PO by.:o 0 lGuptnopwe enr --_ I sStoorcQrE 24551e,vfaeiniey sexs romton So ver nieroseoris + mamsoreonts Fenty LSeOonNEBnA Cs A -- A opprrrmoi,g lSeesoage,gmaa-- Wee,emSiReRs mocts,srs, FTToEneRrSsChoe. oee,n e SSoJ oaCarainlosoVp IMSiDOEmLLEODNe,,SeFR,oamITiacsTHsael,MCSwsSoshSotSDasrIymCa,Lnos, - EE ststopathotons pxeC rssaanion, SE-- TS sivine. remSrismeton, mite --_ CompanyStes, emerebemseTBH C DayOO relCerM esSob : ea Torii Duron DsooserGrQoupENBTo0 am/Sfhvsooanv/idnegyaniem)Sexd:acerem-- faotresSh-- ion) aninals Sainad et Wicxorsopis 4 Wacronsopie Fintinm Fm Teeavrdeaieornnh oSeearstia+ t1sa3sres En Te ramet bom necropey Gross pathology No MFRioaocvxreoosns,,coSpRriIc SAb,nSorrLmoaaNlmGiSt,CyoSorW Rb,AsReRrS:vheodGug KnG:eLnETDALeL MUoSCnLE,Su SPLEEEN, PHNNOOODOELR,RDESAGGALTIiRASnR,Y, IGBSuACn3KIeI9AsRR),IOCTWHDm.TaRCs.DLAPNeErRDe,oNnSaEeaRmanErOaaVnaTERshLeCLcsn, FGLANED (EFEMALSEo),t,OVAmRIaES,nOPeEsR. her, nA essuzs ~ ffTetrrmioirnmal sacrifice A Ena umes off com necrapey Gross Pathology No MTHaTOrcLRvrTaoEAns,,coEBpKaiIanccRahANibnm,gSo,PrILmCNOaBANlCGLiUScN)Cy,oBoCDebOnsLveOnSrN:vo.emSdMAKSRG:LLREATMpA.LoNWOoSeChLEb,orSPLSEaENr, RNOOORBE,ALSAGLLIAVNADRSY. 15S0C0I0N0F,LCOWARBE.ABaEreor mioT"RCLTH 655025 Continued on the next page... _ _-- CompanySaiized Dossnotcontain TSCA Cal C 9R 0DayD Ora Gw aO vageoSadyu in . RtsGoxwic;geSodyinkpDwa uepowntss 9e47s8 ~ sty (R49Sf1haomwing anIinmdailvidduaatla AfonrimailndLiviisdtuianlg animals Dose Growp II 0 mg/kg/day Sex: Females Animal nef Wicroscopic & Macroscopic Findings S502 Continued from previous page Gross pathology : No MaTPcHHrIAoRRsOYcINoD/pLGiLcAARNAYDbI,n,oPmEAaVRlENi(TStH)yYRWOOIbITsDHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPMHoAGaUSn, GPLEAMNUDR/R(NFEEEMALGEO)T.H,OVASRTIEERSN,UM,UTNEROUSSE. VAGINA, URINARY BEADSER, Histopathology : LaverINFLATION, FATTY CHANGE, MSEUDBIAACNUTEC/LCEHSR,ONTmCi,ninmailn.imal. smnC:ARDIONYORTHY, minimal. --_ No MiKSIcPDIrNNoEAsYLcSo,CpOiRcLDU,NAGbSSo,TmOMaSAlKCEiHLt,EyTDAUOLObDMsEUeNSrUCvMLe,Ed, J:ESSPULNEGEMN,, AIOLRTEA,, PBRAANICYR,AS, GSCLCBAINCADT,SI,CCMNOEALRONVNDE,I,BURLBEACITRTUUMIL,TIAMRWPYBHSNGEOLNDATENE,DR,ITCHTYHLMYYURMSPO,HIDOADGDLREAE,NNDA,LSAGLIiVaAnRgY, SOPYVASAR(RASIT)EHSY,WRIOTUITHDERGOULPSAT,NIDCSU,RNEIRNTVARERA,YCHEBSRLK,AIDN,DBESROM,PAHMAFOGERUMSYU,RG/LRPANHNEADER.VJI(OKFI/NLNTAA.RYLN)|Y, STERN, ZONE MARROW, NOSE --_ --- Company Saritzed. Doesnotcontain TSCA CBI C20DOOmMGaMgeS)y .ps.7.c Dupmsns --_ sue (sscSfheonwing anItnedaitviSdeucasl aSnioonrt Laistti?ng snimate Sone Gio 10 maivasany sexs semaes forme Niroscopie & vacrorsorie Finsings or T rear Seaerastmizie RL EEiRes 2 bem mecropey ---- to aSSLsooeivnokennn,,c,opaEBiincnacashirem,oS,rrTaCanOtNmhiSt,rCyoSdnSbnoooneoSrnnveeedoS+nmeanompscagr,sSsPeLveEnE, FSTRiooomnmtaaihnSmCCHLiIan,nR,e, i a BSAiSm)iAcaWmnasASmoNaoeAaArA,SLeTaoomneSsMMaoaorresEb,ArHLiaCnLlcliss,, GTina(nFRAsLaEYriGoarmaa,nHEmRaE enn, hat -- ~ LavT `s irsT acion,AsmTcoTre/IciCmonSte,, minisal. i --f ASDROr NEFHRa OSTS,sBILAeTERAL,emriiosal, Rie etiie Sanion --_ A won Company Sais. DossntcontinTSCAGal C 50DayOraO lGavageStM udy inRats. 1c Dupons9478 -- stony: (BasSshfoewning anIinmdailviddautaal AfnoirmailndLiivsitduianlg anisals Dose Growp : IT 0 ma/ko/day Sex: Females Anisal Raf Microscopic & Macroscopic Findings asson Continued from previous page Histopathology : asson2 Gross Yo MSLiTUcNOrGUoSAs,CcHo,pSiKDcEULOAEDbTEnANoLUrNMm,UaSlCJiLEtEJy,UNOUbSMPs,LeErEIvNLe,EdVNA:,ORTEAA,NCRBERAAST,N,CSCPUIMN,ALCOCLOORND,, PLREIICTETURUIMT,ANORDYMSE,GSLEATNNHTDYE,MRUISTC,HYLARIDONRIPEDHNNGALOLADNEGD,L,ANSDABSLA,IRAVTASWRCYYIRNOFGILIADCNDGNSEL,RAVNEDM,SA,NDIBULAR OBTVYRASAR(CSIH)EESA,,VITUBATSEORPOUHPSAT,GIUCSU,RNEIRNPVARERA,YRYBNSLKKAI/DNL,DAEKRIW,NMXM,FDERMYUR/GKLNAEDE J(OFIENATL,E), STERN, BONE MiRRON, Nos KTeirlmliendalonSDaacyrif: ic50e AEnxipmoaslureisGrsoiugpned: o3f0fDAYfrom necropsy Pathology No MAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTrS,vTOeWdSAKCE:HL,ETADLUODWEUVSGCNL,E,TSaPLrEoEN,, ANIODLDRESUE,MN,ALSAPGLALINACVNRADERSAY,S,GSLACCNIEDCASUT,NI,CMACNEONRLDVOIENB,,ULPARIRETCTULUIYMTM,APHRYMNEOGSDLEEAN,NTDE,RTIHCUSL,F GPTLHHAYANRRDOVIID/(FLGEALNRAAINLNDEK,),, POSAVYRAEAR(TISHE)YSR,WOIIUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAASC,,HEAUS,RKIINNE,ASROMYPAHABMGLMUAASDR,DYER, 655032 Continued onFEthNeURn/eRxUtESpGaOgTeHT.,..STERNAM, NOSE -- - Company Saniized. Donoecontsain TSCA CBI COO eyT)R. E S.l . Toxicity Donors _ Showing anP teas deen foT r individual anisals se siren Dose Group : Seine wet II 0 mg/kg/day Wieroveapke & SeHxa:croFseemoapliees Findings Fh Continued tron provioss pave Histopachotoy : wsavaersTR -------------- chsozOHORATIY, minimal. Ho MiKScerEiorsIcao,pGiocCnN,AGbESm,oPmSaNKlE:iLcByVDAOLUbCsOeIBrRCvLe:Sd,E:Sehug,e, Torwen,, aamaainn,s, CCSEEAaENAc3AT,TI,EYCROWNOLoADOnRN,G:LDARENEPDCRSTE,ORrR,TRnVNABCoHmERSMAooR,pnEeeR,sSA,CH,oTLmAG.oS.SSMOSooRHErnR.astSLaAASe!, EGSiRrnSAaT)mEs,,WISOTToHEvRaOGFSa,CoGNnRERRVEnE,achBGRIAN BRARBeE Cha perp eos r i[ trmbgta-- hl 2, ea a rome SE8 bom necropey aeons rthotony : E MCToiinvmtiaan,,, TSy IAoANwACNvTEsA,SS,PLACNRm oSse,C,ORW--DCE,ORLEOB,NTM r.oSmAiSRnEGeRNmD.aOWWuREsAcErRsE,TRsSeevanem,i 655035 continued onNStOOhERe,EmLSeAGLLIApVNaADnRSgY, GsSiCiIoNgF,ACHRoANRLEB,VLAPReDroeocmhmShae Pa eeer ss=eae--i iepeeeeepe eeamm-- Samper Sarted. Doss ota TORTS! C 50.Day OO ralGavaR geStayY ivnRaitsc) ovis DuPort9478 -- stor QR: Schoonwing anIinmdailvidduaatla afnoirmailndiLviisdtuianlg animals Dose Grob + 11 0 ma/ko/day Sex: Females Animal Ref Microscopic & Macroscopic Findings S303 Continued from previous page Gross pathology : Yo MaTPcHHrYAoRRsOVcIIoD/pLiGcLAARNAYDbN,n,orPmEAYaRElM(iTStH)yYRWOOIIbTDsHerGLvOAePNdTDISC:,NETRRVAEC,HEAS,KINE,SOPWHAAMGAURS,Y FGLRANRD/K(FEEEMAJLOEI)N,T,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology No MLiicvreons,copKiocNEAvoSmality Observed : 655036 KTeirlmliendalonSaDcaryif:ic50e AEnxipmoaslureisGrsoiugpn.ed: o9f0f0Afrom necropsy Gross pathology : No MALaOIcRVrTEoARs,,copBKRiIADcINNEA,YoSm,SmPIaLNUlNAiGLtS,yCOROHDEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSGCHL,E,JESIPULNEOZNN,, ANLODEDROEEN,N,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUT,N,CMANCENORLDVOIENB,,ULARPREICTTLUUYIMTM,APRHYWENGOSLDEEAN,NFDE,RTEHCOULS,PH GTFLHHAAYNRRVDOIIOD(UF/GELLVAAARNLYDEE,),, PEOAYVREAA(RTSIH)EYSR,WOIIUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HERUS,KRIDNBA,SROYPMHAABMGLMUAASDR,DYER, 655036 Continued onFEthNeURn/eRxNtEpSaOgTeHT.,..STERNGN, NOSE eeee Enee-- e -- -- -- e GompanySantzed. DossnocontTaSAiCnBI CO0DayOralGavage Studyin Rrtsc:Toxicity Duponts478 --~ stor {gENacsS1hoo/nwing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals Dose Group : I1 0 ma/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings ss5036 Continued from previous page Histopathology : LIveRINFLATION, PARATHYROID GLANDS S: UBACUTE/CHRONTC, minimal Xo? PRESENT. No MBiKRIcADrINoNEs,YcSo,pSiPcILNUNAAGLbSn,oCOrRHmDEa,AlRiTSt,TyOMSOAKbCEsHLe,ErTvDAeULdODM:EUNSUCML,E, JBSJPULNEUEMNN,, AIOLRETUAM,, GSPLAAALNNCIDRVSEA,ARSY,SGCLICANENCTDUISNC,,NEMCRAOVLNEOD,NI,BUPILRETACURTIUTLMAY,RMYPMHEGLSNAOENDNDET,,ERITTCHHYYMRLUOYSZM,DPHGALNDAORNDEDEN,,AL O`EVTYRASAR(CISKE)ESR,,UIUTETHSEORPOUAPSAT,GIUCSU,RNEIRNPVAHERA,YRINBSKRLIA/IND,DAERRN,IA,GFAERVYORG/KLNAEDE J(OFDENMTA:LE), -- STERNUN, BONE MARROW, NOSE sssoas TKeirlmliendalon SDaacyrif: ic1e75 AEnxipmoaslureisGrsoigunped: oSfAfTELfrom necropsy Gross Pathology : No MaLAOIcRVrTEoARs,,copKBiIRDcANTEA,YbSn,oSrPLImUNaNAlGLiSt,CyORRODEb,AsReTrS,vTOeMdSAKCE:HL,ETADLUODWEUNSUCML,E,JESIPULNETEMN,, NATODLDEREUE,NN,ALSAPGALLNIACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULPARIRETCTULUIYMTM,APHRYMNEOGSDLEEAN,NTDE,RTIHYCMULSY:MPH 655015 Continued on the next page... --_ _-- ET `CompanySanitized. DossnotcontTSaCAiCBnI Dry--Ore)lGa.vage.Sy.n.Ra.s Toxicity Dupont 9478 -- srooe Sco Showing anIinmdailvidduaatla afnoirnailndiLviisdtuianlg animals Dose Group +1 0 mg/kg/asy Sex: Females Aainal nef Microscopic & Macroscopic Findings Sasa Continued from previous page Gross racholony : No Ma"EcTRrHAoYRsRYc0oDpCGiALcRANIADbN,n,orFEmAVaRElNiT(9tA)yIRWOOITbTDsHeGrOLvPAeNTdDISC:,NETRRVAEC,HERS,KINE:SOHPRAAVGURSE, PGLEAMNUDR/(KFEESWAJLOEI)N,T,OVASRTIEESR,N,OTENROUSSE, VAGINA, URINARY BLADSER, sss062 TKeirlmliendalonSaDcaryi:fic1e83 AEnxipmoaslureisGrsoiugpn.ed+ oRfEfCOfVrom necropsy Gross Pachology --_ errorTzaanryo.Gum : Yo MAaLOIcRVrTEoARs.,copKBRiIAcDINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORWODbE,sAeNr,SvPeOSdWKACE:HL,STDAULODMEUNSGCHL,E, JSEPLSETEN,, NRIOLDOEEN,R, SAEGLALINAVCNRADERSRY,S,GLSACCNEIDCASOT,ME,CMANCENORLDVOIENB,,ULTARHREYCLROTYI,PDHGNLNEAOSNDEDEN,,FEMRIvCCEL,ik OEEVAYAR2RA(IT)ERSY,WRIOTUTHTDERGOULFSAL.NCDSV,ANGEIRTNVRAEA,,CKEUSRRK,IAN,ASRSMYOPAIBNALAGARODSDY,ERG,LPAANFADERMIOE(F/REL/MAIARELYEEI)E.J,om, Srem, Nose 655062 Continued on the next page ... ~ epr -- =ere eep tepmmsirimimeesesee CompanySanitzed. Goes not contTSaCAiGnB C-- SDayD O. ral Gu avag. eO Stuw indRaytsl icToxiw city geSudyinkDDie uPmono9s 47n8 --~ soy GY20601Sche/onwing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals Dose Group : II 0 mg/kg/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings 655062 Continued from previous page Histopathology LIVERFA5 TTY CHANGE, MEDIAN CLEFT, minimal. KIDNECYHSRO: NIC PROGRESSIVE NEPHROPATHY, minimal. No MiPcIrToUsIcToApRiYcGLAbAnNoDrmality Observed : 655065 TKielrlmeidnalon SDaacyrif: ic1e75 AEnxipmoaslureisGrsiogunped: SATEL off from necropsy Gross Pathology : -- + No MaLIcVrEoRs,copKiIcDNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdKELETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSGEMNN,TERJIECJUNLUYMM,PH NADORDEEN,AL,SAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULPAIRTLUYIMTPAHRYNOGDLEA,ND,THYMUS, TPHHAYRRYONIXD/LGALRAYNND,X, PEAYREA(TSH)YRWOIITDHGOLPANTDISC,NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTNEORUSSE, VAGINA, URINARY BLADDER, --_ _-- 0s CompanySanitized. Doesnot contain TSCA CBI CNO5D0.yDOsyu: OlCleGvagvae: gseuSlyyic innkRaetss. . ovicvy Dpuwreownosn4s7s8 -- sve OR 2c Srheonwing anIinmdailvidduaatla AfonrimailndiLviisdteinnsg animals Dose Group : II 0 my/kg/day Sex: Females Animal nef Microscopic & Macroscopic Findings preron KeirlmliendalonSDaacyrif: ic18e3 AEnxipnoaslureisGrsoigunped+ oRfEfCOVfrom necropsy Gross Paholony : Yo MAaLOIcRVrTEoARs,,coSpKRiIADcINNEA,YbSm,oSrELImUNaNAiGLiSt,CyORHoDEb,AsReTrS,TvOeMdSAKCE:HL,ETDALUOWDUSECNL,E,SSoPLUEE.N, NATODLDREEOE,HN,ALSAPGLALINACVNRADERSAY,S,GSLACCNIIDCASOT,MI,CMNACEONRLDVOIENB,,ULPARIRSTCTULOIYNTM,APHRNYENOSGDELEN,aFE,TNHIvCMDLE.b PGTHLHAAYRNRVDOIIXD(/PLGOLALANEYD),,, POEAVYRAEAR(TSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HERSU,KRIINNE,ASROMYPHAAMBGLMUAASDR,DYER, PEMUR/KNEE JOIN, STERN, NOSE ~ Histopathology : xmrCsRRONIC EROGRESSIVE NEPHROPATHY, minimal. Yo MiLcorvoesncopic Abnomality Observed : assors EADxucprcoaistduieronentaGolfrloyduopKsiit:nlgSe-dDdRayYe: 15 Animal is signed off from necropsy Gross Pathotony : 635071 Conimaesdtaonn'cFitlhien,mexxte.page... --~ r -------- "Hr eeee rere Company Sanitzed. Dossnot contTiSCnA Gel ODeY C)e.m. n . Doss _ sooo (EY20e9S1hoo5mwing anIinedailviddueacla rfoorimailndLiviisotuinntg animals Sore Gioup + 1 0 myska/day Sex: Females Nina mat Wiaroreopie & Waerorsopte Finting Swan Continued fron pravioss pore Gross pathotony : o-- n SERFORNFION, LANGE CLOTTING TX AREA OF FNCTURE. Gnas, mam, vous Ho NaSF EcvAreNonGs.Rcr oEpE,iicDCeAehe bSun,o,rmTCaNi oltsiot,ny, MOr Rbosiaencr,hve.e SdKpi:LSEaTvAEa LRwSseci LTE,io seSLeEsEsN., CECSOAAETLRIIADCVT,AHNRAEYOSRTGSEDL,ANNGHDLTASaN,IDvNSA,aAEDLFICAAUoCPLHEmAERNRO,T(ELABATROIYAENRSCELNaovvAEeC,.VRATRAESaASvN, eVGCEaCmsEthee,ammi retaryce en Tn ~ otopatholony : . o aveAs F LASATION, SUBACTTE/CHRONIE, minioal. we a TIRPCPSNRBANSTIIAO,N,GRSAUIBALCOUCTIET/ICCH,RONmIiCld,. severe. 655071 Cont nsed on the next page .... ----------------=eestor CompanySaniized DossnotconTtSCiACna C w 20Dayo ORRy tyc Onoo wcc Gupsubiaot wDueposne ioorss -- stor Q2E4591Sh/oonwing aT nion dacp a ot diesen) antmals Dose Group + HT 0 mava/day Sex: Females peer Hiroreopis 4 acromsopia Findings orn [ro pe-------- Histopatholony : o Mi[CcornroEsvceeo,pnieLUaNAGbSm,RomiTaRglAiRYti )y oRbEsVerEvRi eSd N:USCLE, eSPLaEEN, Arcko, r pPnocRsEne eg, Cp BC, e Coton.aRLFUt R. Ee STEar RS Lfo Syonn OPTAIRCERXOeTmTRD,nSELnAnsso ,MBMACRKERCLPo AARRFAEAREI SBrRe)oy mSiotns, sssom2 TFEeeisrlmmeaidrnea.loGnusooaucrpr'if+i+c3e0R3acov fergie S-- ~~ Gross Pathology : 0 NpaEsvrreonsi,cospEiiesErvAem,omaTloniec)y VGObAsReTri ,vedSKE:LETr AL wscLE,r spre, f pIErR,er atncaREa nts,iCoau tonn. yCe oocn. n d RCrURy.iMrEiScNPyEaRCSyRp CTFRonOnND(aFCErAhAakLvE,,Y, PBCAYVSERKATC9TE)ISR,WOTAOSTRECRCLGoASaD.nEe,VNACeGHm, ESBIRRomAAhCSaueSatn,ez, eri Soa as 655072 Continued on the next page _-- CompanySanizd. Dossnco ontaSiOAn Cal c X2D0DyaoyOnrldCivEeSuc RyininSRReaes or wew--em ~ stove (D069Sth:oonwing anIntdeisvidsuaacls AfomrinSafiLviisoteinn)g aninals Dose GLoup 1 0 Ao/kg/day Ses Females pers Nicroscopic & Macroscopic Findings preven Cenimeed Tron previo pope Histopacholony aveINPLAROTION, SUBACUTE/CHRONTC, minimal. No Mipcreosscopic Abnormality Observed 655074 HSTepirolmneiitnraelonGsparecoyrwiti+ c5Se7sAFE A vara Groen Sastiony 1 ~ No MFaCicovrReons,,copKBiRIAocINNEA,YbSm,SoPmILaNIlNAGiLSc,CyORWODEb:AsReTrS,FvOeMdSAKGEHL,ETDALUOWBUESGCRL:E, BSseOLNEENN,, NSSOOEDSRR,E,,SAEGLALNIACVNRADERSAY,S,GLSACCNIBDCNSUT,NI.CMANCENORDLVOIENB,,ULAPRRASTCRLOUYRNPM,RPAHYNERhOSBBaEUt.PE,RSLLEL,o GTEIHAAYANRDROIID(/FGLELUAAARNLDEI),,, PBOAUVRBAA(RR8IA)EISR,WOTIGDRPECROAGNPSEA,SC,VANGESIRNVAAE,,E.SSkRiAnSA.aRoSPTHuABGEsEASDa,RER, FER/KAES SOT, STERN, HOSE --CompanySaitzed.Does not conTtSaCa AiBnl Cs OD SyOo r Gevgy e uc y oTw oxicityomgeinkDureos wnessurs _ suo QaE co1Sc)hoonwing anItnrdailvidduaacla Afonri.maIlndiLviisdtuinn)g animals Dose Gio T1 ma/ig/day Sex: Females porn Wicroscopic & Macrescople Findings pr TBKeirrlomlsieundraelonGSDraecoyruipf+:ic54eSUDRY Se simet S12 From necropsy Gross pathology : 0 MHaILOLIcREVrUTEoMARs,,,copPBKRiAIANDcICNNREA,EYbASmS,So,PmLIaCONlNABiGLNSt,Cy,ORHoDCbE,OsALeTOSr,NTv,OeMdSARKCEE:HCL,HEUTMAY.LOMWSRECSLEES,ETSRePLrELoEiNn,s PTRRHORCNRADRER,ONYIANDLSGA/GGLLLIALAVRDNAYDR,RSY,, GPESLAYCARBNIA(DNT3STH),IYCRWONITNDTDEIRHBVGELOU,APLNTAGIFSRCR,TNOAEARYASRRMSNAG,YHSESGoRknoiena,B.RtOmPrHaaAmGmeInS,t FGLEANND/N(FEESMASLE)o,,OVSARrIEaSm..UTEHRoUsSs, VAGINA, SANA Seanez, --_ ststopatholosy + averI`PIErRLFBLATGIIORN,, SBIULBEACDUUCTKE,CHmRiOnNiIaCc,i. minial. eanasnacmAxiRDRIoGWCOPoAnTsHY, minipal. jriaiiocy 655079 Continued on che next page... -- - ws Gompany Saitzed. Donotscontsain TSCA GBI 20ODr tGayveSy in Rts oc Drona _ Showing anIinmdailvidduaacla AfnoirnailndiLviisdtuianlg aninals DsooverGrQouET)HT2c60sm1af/ovma/day Sex: Females Aina et Microscopic & Maceoscopie Findings ssio73 Continued From previoss pave Histopathology : No MiSKEcPorIwoNEsAvcLeo,pCioncLdU,NAGbSSn,PoOmUSaAKlCEHiL,cEyFDALUObCWsDOeRSrNCvNLe,Sd, JSEPLSEUEN,, ATOLRTRA,, BSRAANICNR,RRS, GSCECaRINcNDN,SS,ECONNLEAORNNVDE,I,BURLPEAICRTTULI,iTHAERMERYSEGNNLOTADENERD,I,CT.TEHLYISRvO:BIHD.NAODGDLREAE:NNDA.LSATCLRILAVACANHRSEY,A, FSESEIOPRAAARKGUESGE,LAPJDORINA(TF,YEVASELTRAE)RR;YGRNO,,VARSBIOYENESSS,)MAURWTRIEORTWUH,S,OWV0UERSRN%CARNYER.VEB.LADGDrER,, 65508 TKEierirpTmoeisdniarleonGsrpaoacwry.it+ i+ c5eS40DAY Firat fo` sioned off From necropsy ~ Gross patholony o MHaXOcVNrEToRAs.,copKBiRIADcINNEA,YbSn,oSrPImLNOaNAlGLiSt)CyORWODEb,AsReTrS,TvOeMdSAKCEHL:ETDAULCDMEUNSGCML:E, IBSTPCLNECERN,, JNTOEDOEBN,,RSAPGLALINACVNRADERSAY,S,GLSACCNRIDCASUF,NI,CMANCENORLDVOIENB,,ULAPRRIETCUTLIUYTMMA,PRHYM.ENSOGEDLNEAT,NERDTIHC.OULSo,WeH FTGHRAAURRYDOILGHD(/FCGELAMARANILDNE,),, PEVAVARRRN(II8EV)SR,OWLIDTUHTEGROLUPASNT,DISC,VANGETIRRNVAAEC,,HEAUS:RKIINNE,ASORPMYHAAMBGLMUAASDR,DYER, FERRER JOTI, STERN, ROS 655083 Continued on the next page .... -- Company Santzed. Doss no continTSCA Call (EO r hS ..e.., .1 nso ~ gp IST SI--I es, O soooe QMy cco1, on sens rmsien eines kernels + aero Findings FE avin rm sree eon esostheions son J,cI eo Mesos msTm s SShaoseesCTuL,E,poSv, OBrt,nSJIe ET Tana GaSompo,airmeSsmos sas;ams. ~ CAEE ee EHRELA LE, en cron to sSA nczEssaaSpinSmiaoaTmatoanmcSeoheneemreeedunm,nnVmoE.neE. Rsahme:n om aSTmo aisomr ~ JS -- CZROyOOralCovGaavgageeSStuuddy yin iRantsiRc Teosi_cy_ DuDPuPoowndt9a4l78g ~ Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals DsorsoeoyGrQouRp ): I2I46091mg/fkegn/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655093 Continued from previous page Gross Pathology : No MaTcHrYoRsOcIoDpiGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDYNK(/FLEAMRAYLNEX),, OBVYAER(SI)ES,WITUHTEROUPST,ICVANGEIRNVAE,, USKRIINN,ARYMAMBMLAADRDYER, FEWUR/KNEE JOINT, STERNOM, NOSE 655098 KTeirlmliendalon SaDcaryif: ic94e AEnxipmoaslureisGrsoiugnped: oSf0fDAYfrom necropsy Gross Pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y HOEbAsReTr,veSdK:ELETAL MUSCLE, SPLEEN, ~ AIOLREUTMA,, PBRAANICNR,EASS,PICNEACLUMC,ORDC,OLOSNT,ONARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH ANODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,ICMANENRDVIEB,ULAPRITULIYTMAPRHYNGOLDEA,ND,THYMUS, PTHHAYRRYOIINDX/GLLAARNYDN,K, PEAYREA(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINE,SOVPHAAMGMUASR,Y FGELMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : KIDNEYISNFLAMMATION, SUBACUTE/CHRONIC, minimal. 655098 Continued on the next page -... --_ -_-- ai6Company Sanitized. Does not contain TSCA CBI CMDeO ydOrs} Gyavig o . Styuin RtGxnc agSodyinkoDwauoows omsos ~ roe cc iShnowing nIinndai)vidduaatl aFnoirmailediLviisdteienlg animals Dose Group : Seiad ot II 0 mg/kg/day Sex: Females Wicroscopic & Maoraseopic Findings sso Com imied From previous pose Histopathotoay + sane mn BiAboER ---- TNPTMBATION, SUBACUTS/CHRONIC, nintnal. No MiEGEcERrDRo,s,coSpTLoiOucNnGcA,hb,noSrK`mEDaLOlEOiTDtAEyLNOMOObSSsOeELrYSv,eHdS,PLETENL,EAORPTAA,RTBERA,IN,CoSePL NCNEoARrDVoIEnS,,UL"FAIRRTEUCLYTOI,VAERRYNEGNSLOEADNNETD,E,RLTTCDHYTSRY,OMLEDADGHLoRADENRND:A.L ACHEN, BSOPHAGUS, PHAR ARE SGSALHLaRLvUeARsAG,SROGSNLeSArNuEDRRe.'S, NCSoUURsBReSI)ES.WITGTHEROGPST,ICFNEEMROVRE/,KESSKAJ,OINWTA,NASRTYERGLNA,NDSO(PNELWEA)R,K, ~~ esos EKSreipmolimenuarleon'Gspraeocytr.pi.f+ i+ c58eJ0DAY Aetna is signed off from necropsy Gross Fathotony o MAaLOIcRVrTEoARs,,coSpKiIADcINNEA,YbSm,SoPmLIaNUlANiLGtSCyonOWdbE,sNeNSr,TvOeMSdAKCE:HL,ETDAULODMEUNSOCRL:E,TSSmpeae,, 655099 Continued on'RRTOtOLDhSREeUE,NN,n,eSsAEtGLALRIApCVNaRADsERSenY,S,G+LSACCNIRDCNSUT:MI,CYANCENORLDVOIENB,,LARRR.TGOILRPY,AMRPHYW,OEOBSRMnF,E,RRSGRLower ey eeeerst: Gompany Sanized Doss nco ontTSCiACnB C 50.DayY Onl Gava. ge Sty. in Rts . icity Duponcs478 --~ sre 0Showing anIinmdailviddautaal fAonrimanldiLviistteiansg animals Dose Group + 11 0 ma/ko/day Sex: Females Aninal ret Microscopic & Macroscopic Findings G3s09 [Ep ------ Gross pathology No MGaTPLcHHArYANoRRDsOIcZOoD(/pFLiGEcLAMARANAYLDbNE,n,)orPOEmAVYaRAElAR(iTISHtE)IySR,WOOITbTUDsTHeEGrRLOvUAPeSNTd,DISC:,VANGETIRRNVAAEC,.HEAOS,RkiRnNE:ASROYPvHamAeGeUasSmt,eer, FEMON/REE Som, STERN, Hoss Htatopathology: KLaavoewIsNF|LATION, SUBACUTS/CHRONIC, minimal. CHRONIC PROGRESSIVE NEPHROPATHY, minimal --~ o MCiLCOOUcLRNrODGoN,Ss,,coSHRpTEEOiCAUcTRAUCTAMH,b,,mSoMDKmEUGaSLOlEEDiNTETtANELyNR,IMoCUbESsCTeILrHETvI,eMNd,SKP:OLDETEEE,N,RS,ACARBTLAe,IrBneRAsTNA,SeSoPInNAL TMNREAARNCVDHEIE,AA,LPAIRETSUOLIPTHAAARGYTSNG,LOADFNERD,A,RTITHIIYGNRGOASL,RDAGDLRAENNDA.L HGraNvenM. SReramncctk, EOSYVTEAE(RSIR)SNS,,WIBTUOHTENREOUPSMT,AIRCRUONRWEI,RNVAENR,OYSESSKAIDND,ERY.AMFIAURRY,GaLAeDs r(FEaNALE), --_ - wm Company Sanitized. Doesnot contain TSCA CBI CO terre Tost Duron f Showing anIinodnisvideuanl For mvionn) Animal Listing animals Soret Bo mesrarday sex resales nina wiarseopte x Faveorceria Finite ie LIed raoheen necropoy ------ to WfaETcvormiossr,.eopEaticioehviesvnidsmg,o,rTsCaaolNseat,yyooobasoeernnveSdae odgueem WseeuEn s,Eso heae, ASFAAreERaRnsCCSAuhRmeRs,. CBiLEERSc,) WWmiEmnHTISBS NeTEHrR mSoenrenn aaasses,y Ginn (FEAL), SiRALRS, GYEoRnGcS, AER, SNA Beaman, --_ Mistopath-- olonEyRR+ONIC PROGRESSIVE NEPHROEATRY, mininal pr Pp sne gweoese e rer miss CompanySoran, Gossotcontin SEACH! {O I ccicity Dmons ~ Tore IN roning TSirEti nT im utshie ns LIE,1) tees Fonaten rn HA EoR m. t Bn seceonny SoBarrEntrHEeroirensn,r, TsConhetos,nSOcroeouTa naSa usea. spswos,ctus,TSsoEeuazAma,., TEASroRannDeARCSaAaDToaES,,, CaRSeooeaAA,iiRnCOSIYMoEDRuLUSmLo,Di%SPa,,ITLTURiIEenTCeaTAr,RcYvhECe,oSI,SIsN+CoDrLsi,n, BCRT E D Sen mel,TIOPTIC NEE: Son pant sisspsatany ~ savenL O A nnoimneyeSr SooNMCCISmoEILSErYOoCJmK,aoDmoUDsEecis,ESPsTLeEOuEsNN,,,noToTLvEe.,, SE EPhiRanToi SncCAaSMnSen DaIEFipLLTh2ToOCyTOTMeLYMJSBIocSNnBDgE:,RhITTCvLOo,te TSadLooav).e. aDo oes (ros --_ -_-- mmm-m ComparySarco. DossnotconnTSGAGE! O X 0-DaL y OraDGR avau ge SuO dy in: n Rats l 10x GegeSudyinRDDuuoe Pomno.s 4m7s8 r Showing anIinndailviddautaal AfonrimailndiLviisdtuianlg animals sDooseoGr(oupD: 2IT46091mg/ekng/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655109 TKielrlmeidnalonSDaacyrif: ic1e03 AEnxipmoasluriesGrsoigunped: oREfCfOVf.rom necropsy Gross pathology Yo MAaLOIcRVrTEoARs,,copBKiIRcDANTAE,YbSn,SoPmLIaUNlNAiGLSt,CyOROHDEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E, JSEPSLCENEGNR,, NAIODLDREEUE,MR,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNBIDCASUTM,I,CMNACEONRLDVOIENB,,ULPARIRETCLTUUYIMTM,APRHYWENGOSDLEEAN,NPDE,TRIHCOULYSMPH GTPLHHAAYNRRYDONIKD(/FLGEALMRAAYNLNED),X,, POEAVYRAEAR(TISHE)YSR,OWIIUDTTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,RKIINNE,ASROYPNHAABMGLMUAASDR,DYER, FEMUR/KNEE JOINT, STERN, NOSE Histopathology : ~~ LIVERHY:PERPLASIA, BILE DUCT, minimal. Yo MiKcIDrNoEsYcSopic Abnormality Observed : --~ _--_-- CompanySanitized. Doesnot conTtSaCAiCBnI CO0D-DuayOOunllGGnavaaggeeSSuiddyiinnRRaasvisc Toxiciy Douupoonmto94m78s ~ JShowing anIinmdailvidGuaatla AfnoirnailndiLviisdtuianlg animals Dose Group : 2 1 ma/ko/dsy Sex: Females Sina nef Microscopic & Macroscopic Findings py KTeirlmliendalonSDaacyrif: ic54e AEnxipmoaslureiGrsoiugpn.ed+ oSf0fDAYFrom necropsy Gross zachotosy No MAaLOIcRVrTEoARs,,cop3KiRIADcTNNEA,YbSn,SoPmLIaUNlNAiGLSt,GyORHODEb,AsReTrS,TvOeMdSAKCE:HL,ETDAILGDMEUNSGCHL,E,JSEPLOENEN,, NATOUODEEOR,H,,SAPLGAILNVACANRRDEYSA.,S,GLSACCNIEDCNSOT,MI,CWNCNOEDLRIOVBNEU,,LARRPEI.CTTLUOYINTH,APRHYMNEGSOLEDAN,NTDE,RAIOC EL.imb GTBLHEAYANRRDOYIID(K/PGLALALARNEYD)I,,, BEOAYVREAA(RTSIH)EYSR,WOIZUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEASU,KROINNE.ASROMYPAHMABGLMUAASDR,DYER, FEMUR/KNGE S013, STERNOM, NOSE Histopathology ~ No MKiecorvoesvceopic Abnormality Observed : esos TKeirlmliendalonsbaacyrif+ ic1e75 AEnxipmoaslureiaGrsoigunpe:d oSfAfFELfrom necropsy Gross rathology Yo MAaLOIcRVrTEoARs.,copSKiRIADcZVNEA,YbSn,SoPrILmNUaNAlGLiSt,GyoOHnbE,sAeRrS,TvOeMSdAKCE:HL,ETDAULODMEUNSGCHL,E,TESP0LUENEMN,, ANTDOLDREEGE,NN,ALSAPGLALTNACVNRADERSAY,S,GLSACCNIBDCASUF,NI,CVNACEONRLDVOIENB,,ULARPREICTTLUUYIMNT,PAHRYMENSGOELDNEAT,KEDR,TIRCV.HSvEi, i 655018 Continued on the next page --.. --_ ee -- = eene s eee Gompany Sanized. Dossnotcontain TSCA CBI I teen Dura ~ rsrrre (IcehsSeh:avitngyavaitotavtSiednausanytrensSautieosnAd LisLsing re = Sinremte emmeennni Fendi Pr Concinans fron pesvions sins S TCEEnArEtaR emA, SBoameAas rTeCrONeTE.ATBCR:E,Ssnommveas,nt TRS enter,Sr J-- eT secnmsanaet snsacrti,isca , ERs ST cecropey cress sachtony - - So WRpBroomErnaon,m:,eeBrpEtaicnnnsniosmnoGreTeeonamteaihst)by SuooobaseerSuTorrdveekedAerLpaIS,LRMwUuSsOCLsE,TSsrEray.,, Pf mHmoimarnSChCeahanana,eei,nBmaosaneaiRSSamOIyRULaLaSno,Ls RRACECOEKTED,,SNSMeoESoA Osm,TwCe.UrLSic, CEs BALE Sorieks Ds En: Sn INR -_-- CompanySatz. Doss nt containTSCAGBI C Day O rlGava) ge Sty ncRiec cy Durons478 --~ sor (UcSthoonwing anIinndailviddaucael afmoirnen)diLeiissteinntg animals Dose Glow + 20 msko/dsy Sex: Females rrp LE -------------- sein TSKerirplmolirenudraelonrSbaecevryoi:fi+ c5e4S0mAY Antnal 0 sianed off from necropsy Gross Pathology : No MAaLIOLIcREVrTUEoNARs,,,copBPKRiAIANDcICNNREA,EYbASnS,oS,rPLImCONaBNAlOGLiUStM,Cy,ORNoDCEb,OsALeRSrO,Tv,OeMSdARKCBA:HEL:REUTMBALLYONWRECERLESER,TSESeornmm,s BFTNOHUODYARERRE,OIAINLDSGA/GGLLLLIAAAVRNNAYDDRK,SY,, LPERSDYACEINS(NIS,RH)LYCRWOMINTATEDNHRDVGIEOLB,PAUNTLGISASCRu,TNYOEBWhRREmVaERHG:YHoESSmSimen,nmeaiCespieAGsrOS, CFELNAUDR/K(NFEESMASLoEr)in,GVASRTEEASR. .UTEoReUsS, VAGIA, ORIN anigr, Histopathology : --_ reCHRCNTC. PROGRESSIVE NEPHROPATHY, mininal. sssoa0 ETKxeiprlomlrieindraelonGSrbaoceurpyi.:fi+c5e400KY Aina 1s sited of zon necropey Gross pathology : No MLIAaIOcLVRrETEoARs,,,coBPpKRAiIANDcICNNREA,EYbASnS,So,or1DmNCOaANlBGLiCSt)C,yORoNDOEb,AsLReNTSr,Tv,OeMdSARKCOE:HCL:TEUTRBA.LYMwoOEScBLAE,RJESeeuTgmae, 655040 Continued onANDOtRDhEEe,NAnLeScKkGLlIpaVAauRsgY,eG.LSaCNIDNSD,ICMANNEDRIVBEO.TAeR.roAreInMatmsaerni!roe -- - Gompary Sanitized Dossnot contain TSCA GB C 50.DayO Oral Gava) ge Sy. in Rate ovicity DuPont9478 ~~ rove Ro:Showing anIinmdailviddaucaal AfnoirmailndiLviisdtuienlg animals Dose Gebup : IV 1 mi/kg/dsy Sex: Females Animal nef Microscopic & Macroscopic Findings prem Continued from previous page Gross pathology : No MaBTHcHAYrRRoIOsNIcKDo/pLGiALcRAYNAIDbS,n,orFEmAYaRElA(iTStI)yIRWOOITbTDsHeGrLOvAPeNTdDISC:, NETRRVAEC.HEAS,KINE.SOsPoHAuGmUiSn,t GFLMANRD/(FEEWAdLoEm),i,OVSARTIEERSN,M,GToERSS, VAGINA, URINARY BEADSER, Histopathology : Yo Miocrwosscopic Amomalicy Observed sso TKEexirplmolisenudarleonGsraDcaoryuipt::ic54Se0DAY Animal is signed off From necropsy ~ Gross Pathology : : No MAaLOIcRVrTEoARs,,coKBpRIiADcINNEA,YbSo,SmPaLIONlNAiGLtS,yCORHODbA,sNeSr,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML.E,JSaPLsEoENn, NAIORLDEEE,A,LSAPGLALINAVCNARDRESYS,,GLSACCNEIDCESOI,M,CMANCENORLDVOIENB,,ULARPRIETCLUYITMT,PAHRMYENOSGDELENA,FDE.SNEVGHDBS,iH GTPLHHAYANRRDOIINDK(F/GELLMAAARNLYDEG),,, POEAVVRAEAR(TISHE)YSR,WOIITUDHTEGRLOGAPSNT,DZSC,VANGETIRRNVAAEC,,HERUS,RKIINNE.ASROYPMHABAGEAUDRSS,ER., 655041 Continued onPEthMeURn/eKxUtEEpSaOgTe,. STERNOM, HOGS - Company Saniizsd. Doos not contain TSCA CBI Cc ODaMyOlGac vage Sty ins Duronsu7s ~ soor QE es92Srhoonwing anIinmdailvidduaacla afnoirmatladlveiistteinntg antrats Dose Group + T0 1 mo/kg/day Sex: Females perm Nicroscopic & Wacroseopis Findings Sissi Continued from previoss pave Histopathology : No Miicroosscopic Abnormality observed + sss0ua EKTxiepTroTmneiindraelonGsbaracoyrwif++ic534e00AY Antal is sighed off fcom necropsy Gross zatholoy : 0 MSaTLOIcLRVrETEoARs,,,copPSKiTAIANDcICNNREA,EYtASmS,So,PmILaCNOlONAiGLUStN)Gy,oRNoDCEb,OAsLReOTSrN,Tv,OeMSdARKCEE:HLC,EOTDANLEOWMDRSBECL.ES, TESPrLssEeiNm,en - TAPNHODDIEHRR,OI.AD`SKGGRLLiIAaVNnA,DRa,Y, PGBSLAYACRBNIA(DNT3STH),EYCRWOMINIDTEDTRHVBGELOU,APLNTADIBSRCr,TNEUEVFRYESMRA.GAHmERSoo.KpnI.NiB:S.OSPTrAaAmeGmUenS.t FGLoANnD/K(uFEESNAoLEt)i,,CASREeSaS.r.UTEnReDsSs, VAGINA, OREAARY mene, Histopacholony : No Miocwroescsopic Abnormality observed : --- TTT Te Company Saniized. Doss notcontain SCAB! C BDayOO o nlCagy . e yo p.ew. 7:5o , wstoikeDwoess sisw ~~ sSotroerG(ASUM0a1 smSiohsovonwainngyanIinadsitvSeixdd:uoatlsremASantiemmsal LaistIing irate at Winoreepte + Testorerie inti Forti rTaeremietanen oSnatmoitirae Ld ST necropsy -- Yo MSaCSocoivrmmeons,,,copESEirenIcoanSAibn,msoS,reTmCnaAhtGseisot,nCy,oPoSnbEsAoeRoSr.vnheSdoaeenmroCaTLwEEc:,JTrELemEMy.,. KRTFiORnROOnEIASLSCCAALLRLAIREST,,, CrBSeOuRAeGe)OmNeWDeoaGnSaoaAen eLSSameEeErME0aT2rR,OnCCcLSH,, TGEeRDA(CEaA)iCiaRnARLsE,S,DSeraRes ann aL SOR --~ sss0s7 r -- Tm y -- SemEio -- to NRaoSocnreEvons,copKSEieaoeoarwrise:niesm,So,reTpmCaOilNoniSt,vCyobSnGsneoeairSmnv,ehdooax:noimnBe aiwoosocus,SSsTeUEuERsO,, RRoEEA, LSCAhs,CegmSaRLTApeLSM0O02R,ELn 655057 Continued on the next page... --~ -_---- CompanySanaa, Doss otcontain TSCA GBI OERT. E. AT . Draws ~ O sr (L 17E 2chong ISTaIEeLreitmepen SA eSsECi SE eatassSto :ne f,ilDm, eATEtR )mtmawnog GryaAes.wTmea,m,shsotw oa,an J I" EeReISl, ener F---- to sLai oceuoms,coKpimcsm,gousmsi,amg aens,ervssS r ee cA ts,seus, ~~ a LBTILaEUsnnM,saf, PTnAaNeC,nLR,,EEASG,i SDorCIlECSiUsM),aC TnpCoOuL,OsSsNo,iSeS LR,Ea CoTNUeM,mM,EWCSSnENSsTnoEeRIiC ynLY,MPH m sosmtine mean ova, wnes aprtes Svssestin hasten ~ -_-- Sempron, BowtieTIA Ce O.r .. fo Pa srr (OY2601chong aA viary Lee Reine wet Dose Group : IV 1 mgni/ekmgo/rdeaoyris Smexe:nroFreemoasltess Fentress S TomineELSR atcriticYee yn econ roms pahotony + TBTooornEmemysDaDanhneE no,snTaR honseees)M,EaSNOTLrSOsNEu,eORbun,AeanCTaw,,secuMsunAesSrE,asa,Rs,IceChLvuemrnmroy,n,, ECFTeiCihsrLoiasEANaRpD,La:E,o CASomsria,las YsoIuCmEae SnTsLICRLSETCeEHS, sa sphsesi,,rmw, oansn,t -- sstomathotosy Ho Microncoptc aomomaivy Gbeerved soso SN Te enn ee voces to vRpaSocnrreeentm,toSDpe tisanMenon,rg masoLinucyodnSheoueA SeveRd E SsOcOeN, Rong shppen CEEn COU, Rach, wastes gsoeEiys,. ori cs, Ha: NDIA Linh Moos CamrySanit. DossnotconanTSCAG1 (DayO Oral GY avage S. ty in. Rats . vc Dupowoi7s ~ Showing anIinndailvidduaatla AfnoirmailndiLviisdtuianlg animals Dsotsoer.GrQoupD: :TV c1omg/ckegn/day Sex: Females Anial Ref Microscopic & Macroscopic Findings as5090 Continued from previous page Gross Pathology : : No MaTPcHHArYRoRYsOGcIHoD/pLiGAcLRAYNANDbX,n,orPEmAYaRBlA(TiSHt)YyRWOOIIbTDsHeGrLOvAPeNTdDISC, NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y FGLEAUNRD/K(IFEEEMAJLEO)I.NT,OVASRTIESRSW,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology Yo MiKcIruossYcsopic Abnormality Observed : assonn KTeirlnliendalonsDaacyrif: ic5e8 AEnxipnoaslureisGrsoiugpn.ed+ o9f0fDRfYrom necropsy ~ Gross pathology : No MAaLOIcRVrTEoARs,,copBKRiIAcDINNEA,YbSn,oSrPmLIUaNNAlGLiSt,CyORHODEb,AsReTrS,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E, JSBPULNEGEYN,, ANIODLDREEEU,MN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNHIDCASUT,NI,CWANCENORDLVOIENS,,ULAPRREICTTLUUYIMNT,PAHRYMNAOGSDLEEAN,NFDE.SRIHCASL,v GPTHRLYAARRDOYIID(/PLGELAMARANYLDNE,,)|`OEPVAYRAEARSTI)HEYSR,WOIIUTDTHEGROLUPASNT,DISC,VANGETIRRNVAAEC,,KERUS,RKIINNE,ASROPYNHAABMGLOUARSD,DYER, 655051 Continued onFEthUeR/nKeNxEtEpaJg0TeHT-,...STERN, NOSE --~ -_-- "5oCompanySaniized. Doss not contain TSOA CBI R RyhoY ivagO e Stuu diny: Ratl s OvepityinkoDe uwPoontw-s94s78s _ soor (assSc1hoonwing anSiomtailvidduanet afmoirneidndLieissoteien)g animals pr Dose Group : IV 1 mg/kg/day Wicroscopic Sex: Females & Macroscopic Findings Ssiost Continua bron previous pan Histopathology --NCHPALCANBIACTIEROONG.RESSUSBIAVCEUTNEE)PCHHRROCPNATTEH,Y, mimniinannatl.. 655095 EKTeirrlpmloiewndraelonGsrbaoecuyrpi.f+ i+ c1Se75NTEL Rokoal 1a signed off from necropsy Gross patholo No MRLaIcOVrIEoRs,,coBpKiIRDcINNEA,YbSm,SoPmTIaINlNAGiLSt)CyORWODEb,AsReTrS,TvOeMSdAKCAHL,BTDALUOMDUESRCCLHE, TSaeaLEms,, ~ NNTODUDRENE,R,ALSAPGLALINACVNRADERSAY,S,GSLACCNIRDOASUT,NI,C KNCAEODRLIVOBENU,,TABRRRSTCPOLOIYNIM,APHRYMNESOGEDRMEAF,NEDA,SGS, ALeb GETHHLAYARRDYORIGD(LF/GELLNAAARNLIDE,)N,, POSAVYRABAR(T5IH)EYSR.WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HENUS.RKIINNB:ARORRWYHASnGeUatSp,eER, FEMUR/ANES JOT, STERN, ROBR e--e --------------------iieteeseiemeii CompanySaitized.Dossnot conTtSGiACnal OX O D Or Gy avigeo Syvim nRiatsc.Gcruy usSudyiRDpue Pwonesos 94m78 ~ So eee Showing anT imalp data for indi-- viseas animals Dose Group "TV 1 ma/ko/dsy Sex: Females Animal Rf Microscopic & Macroscopic Findings Gssi08 E`KxTieplrolmseiudnraelonGSrDaoacuyrpif: i+c54eS0DAY Animal Ss signed off from necropsy Gross Tathotony + Yo MAaLOIcRVrTEoARs,,copBKRiIADcDNYDA,YbSn,oSrPmILUaNNAlGLiSt,CyORHODEb,AsReTrS,TvOeMdSAKCE:HL,ETDALUOMDUESNCILNE,TsEeyetmR, NAIOOLDREEE,I,ALSAPGLALINACVNRADERSAY,S,GSLACCNICDAUSRM,I,CWNACEONRLDVOIENB,,ULARPREICTTLUOYIMMT,PAHRYNNESOGEDLNEAF,DER.MGGa. ev,i GFTBLRHRAMYANURRDROI/INRDG(NF/EGELELMAAARN0LYDE1I,),M, ,`OEPVAYARESRA(TTISEHS)RYSNR,OWOMiI,GTDTdENGROLOGSAPSENT,DISC,VANGETIRRNVAAEC,,HEAUS:RKIINNE.ASROMYPHaABbGEOUARSD,YSER. Histopathology : - o MiKceorwoEsvcSopic Abormality Observed : --~ --- CompanySanitzed. Does notcontTSaCAiCanl O Cr CR ESy pcY oc.7:1 Dons ~ sre (ceoSheonwing anieat ees aaa-- n? sntoate im Dose Group : VI 5 mWgi/kagr/odraeyaic &Smexa:croFseamoarliees Findings RETeemOerueeLoEtraEeistR'ieeSa,nesn neceopey to FNaEoovorenEons,:coEBRpntovecnunssimn,osSi,rmTnCoLoniteostn,yo,oGeChoeonenSe,ovnoeSdmseoeinwoAa pwsScCoiLsE,eSsTeUiEsR,. pBRFoRrnriOeniCGechamares:, Ae SeRrnOanee eperSileTO08c,eesid, T Cir(emias)iGrunes,,DeUenS. ae man RE - ET aitedec2o02ycom mecropey ---- o Maocvreons,copRiIc SAm,ormTaOtNGiSt,y SobEsAeRr.veSd e ma wei, Ser, NNLoonEm, aSEGTmoLAnAiSRn,s,CSCeiovaanWGocauiens, aBSoeDnroieipSOSBe0ER08Te Li 655020 Continued on the next page +... Company Saites. Doss ntcontainTSCACol CD ODaD yOrGuavigeoStas u yin i G ts 7acugeSudyinoRo Duaponm 9s 478 --_ Showing anIinmdailvidduaatla Afmorinai)ndiisvtiidnu)g animals sDotsoerGrQouEp: VI2e6501m)o/okmg/day Sex: Femsles Snizal Ret Microscopic & Macroscopic Findings sss0z0 Continued from previous page Gross pathology No MTaHcYrRoOsIcDopGiLcANADb,norFmAaRlAiTtIyNROoZb>seGrLvAeNdDS:, TRACHEA, ESOPHAGUS, FGPLHIAARNYODNXR(/FLEIANRAYoLNEXT),,,OEVYAESR(TSIE)ENSC,WHI,UTTHEHROOUSPSET,ICVANGEIRNVAE,, USRKIINN,ARMYABMLMAADRDYER, siscopathotony No MiKceroowseceopic Abnormality Observed essoas KTielrmliendalonSDaacryif+ ic17e5 AEnxipnoaslureisGrsoiugnped+ oSfAfFELfrom necropsy ~ Gross pathology : Yo MAaLGIcRVrTEoARs,,coBpKRiIADcINNEA,YbSm,oSrPmLIaONlNAiGLtSy,C,ORHODEb,AsReTrS,vTOeMdSAKCEHL,ETDAULODMEUNSOCNL.E, JSaPsLoEEnNn, ANSODLDOEE,R,ESAPGALLNIACVNRADERSAY,S,GSLACCNIADACSRM,I,CMANCENORLDVOIENB,,ULAPRIRETCTULURYMIM,APHRYMNEOGSDoEEaN,dT.EMNtEoeL:ien GTELHRAYANRRDOYIDI(F/GELLMAAANRLDIE,,), EZORYVAA(RA8II)ERSO,WTIDUTTHEGROLUPASNT,DISC,VANGETIRRNVAAEG,.HENUS.RKIInNB,ARROYPTHaABsGEhUAaSD,SnER, FEMUR/KE JOT, STERN, ROSE --_ _-- CompanySarita. DossntcontTSaCAiGanl C20 OOlMCi. g . ty . ci Dupo ~ so GaonShouing anIinmdai)vidduaanln aFnoirmaaldvLiissteisn)g anisats Sone oro OLS i araay sex: remain per Wicrosaupis & Wactoscepic Fintings = pEErrlpioassareenG--rnotae.--50Sue a iames of2 From necrepey Gross pachotosy : LRF ioveRr,, RSIaE,-- S,SoTo-- vne Gs,CoGnA-- RES,hoSmiAeBmowmeaens,eseraa, FHREaOEOmDRaR,IEEAnLGGTyLIADAR,s,S, SCSBAYEA3ITs(NI5GI)IRCOWWLTDDIETRCESSL.TPAAANRPSRCe,rnLvFeRteRRRYSAcSahpor,eaSeetoaecnaoest, FCLEANSK(EPEBNSLoEl)i,ounSsieRsa,mTEnRoEs. The, ERY Manag, Histepathotocy : ~ Jr--CHRONIC. EROGRESSIVE NEFHROBNTHY, minimal. ess034 Errevrimoinrnaal saceiice Group: 00NY RE Ta somes 962 From nectapey [-- 0 NAaLTocirEzveoen,sn,copRSEiianocmuneA,vamso,,sresTmaCoaionnicsta,Gy,oSonCEs,sAoeRuSc,r,voeuSdaschoh:en.mDiowWunesnScreesE,Eeseeyihsa,i 655024 continued onNAToOhne,oe,SxAeGLIipVnaAgnReY, GSLCI,RCKMONBeIBSAPReL rotnhoSar Pp -_-- CompanySaiizad. ossna conTtSAiGnBI ZuayOOrnlOnBuaveagSe uddyyinnRRess poDuwoem9r47s8 ~ Showing anIinrdailvidduaatla AfnoirmailndLiviisdtuianlg aninals DsotsueyGrowp I c5omgc/ekng/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655034 Continued from previous page Gross Pathology : No MaPTcHHrYAoRRsOYcIIoDSp/iGLcLAARNAYDbN,n,orPEmAYaRElA(iTStH)YyRWOOIbITsDHeGrLOvAPeNTdDISC:,NETRRVAEC,HERS,KINS,SOPMHAAMGMUASR,Y FGELNAUNRDK(EFSE,MAGLOET),HT,OVASRTIEERSN,ON,UTENROUSSE, VAGINA, URINARY BLADDER, siatopatholosy No Miocvreosrcsopic Abnomality Observed : e503 KTeirlmliendalonsDaacyrif: ic54e AEnxipnoaslureisGsriogunped: oSf0fDAYfrom necropsy ~ Gross ratholosy : No MAaLOIcRVrTEoARs,,copBKRiIADcINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyORHODbE,sReRSr,TvOeMSdAKCE:HL,ETDALUOMDUESNCNL,E, JESIPULNEOEMN,, ANIDOLDREEEU,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMANCEONRLDVOIENB,,ULAPRREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTIHCUSv,ip GTPLHHAYANRRDOYIND/(FLGIALNRAAYNLNDEK,),, POEAVYRAEAR(TSIH)EYSR,WOIIUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,RKITNNS,ASRCPYNHAABIGLAUARSD,DYER, 655038 Continued onFEthNeURn/eKxNtEEpJaOgIeN.T.,. STERNOW, NOSE -- -- CompanySantized. Doesnot containTSCA O81 C SCD-- Or C. avageB. ayin c Roe cct Duronsers --_ soe QoShowing anIinndailviddautaal AfnoirmailndiLviisdteinnsg animals Dose Group + V1 5 mo/xg/day Sex: Females Aatnal ref Wicroscopic & Nacroscopis Findings p= Continued rom previous page Histopathology No Miocvroiscsopic Abmormaiicy Observed sss039 EKTxeiprlomlnieundraelonGsrbaoacurypif: i: c3e40DAY Animal is signed off fron necropsy Gross pathology No MAaILOIcLRVrETEoARs,,,copPBKRiRIAIcDICNNREA,EYbRSnS,oG,rPILmCANaNASlGLiCStO:Cy,ORWODCbE,OsALeNOSr,NTv,OeMSdARKCEEHLC,ETTDA,LUCMMbEUESSNCERLMLEY,ERTGSSSpsioLensnb, --_ FTAANHODRDIRIERE,ONNIAGDLSALGGLLLIAAAVNNRADDR,,SY, EGELASYARCENNI(DTNSSHT),YARCWONIIANTDENRHDVGIELOB,APSNTLDIAPSCRU,TNULETTYRRIMVAAPECHR,KYERRSGO.KDuIEaN.Em:S:OSWPIHoAaEGbU,aS,t FGELAMNUDR/(KFEESNAoLEr)i, ,OVASRTIEESR.N,UTEHRoUoS, VAGINA, URINARY Babes, Histopathology : No Miocvreosrcsopic Abnormality Observed - Company Saitzed. DoesnotcontTSaCAiCanll CL ONDiyDOralw Gavago eSd5ui:n Ri ts G xcugeSudyinkoDwue oPowucsssairws r Showing anIinmdailvidduaatla Afnoirnailndviviisdtuianlg animals sDtopseyGrOoup2+ 1VI 5551mat/ekma/day Sex: Females Animal Ra Microscopic & Macroscopic Findings ess0az TKeirlmliendalonsaDcaryif:ic54e AEnxipmoaslureisGsriogunped+ o9f0fDAYfrom necropsy Gross zathology : Yo MAaLOIcRVrTEoARs,,copKBiIRDcANTEA,YbSn,oSrPImLNUaNAlGLiSt,CyORHODEb,AsReTrS,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E, BSUPNLUEENN,, ANIDOLDREEUE,MN,A`LSPAGALLNIACVNRADERSAY,S,GLSACCNBIDCASUT.NI,CMANCENORLDVOIENB,,ULARPREICTTLUUIMMT,AFRYMENGOSLDEASNN,TDE,RTIHCUStw,tr TGPLHHAYANRRDOYIIXD(/FLGEALMRAAYNLDNE,K),. `EOPYVAEAR(RASIT)SHYSR,WOIITUDTHEGROLUPASNT,DISC,VANGETIRRNVAAEC,,HERSU.KRIINNE,ASROMYPHMABAGLUARSDY,DER, FEMUR/KNES JOINT, STERWOM, NOSE Histopathology: ~ Wo MiKcEroEscSopic Abnormality Observed : assos0 TKeirlmliendalonsDaacyrif: ic1e75 AEnxipmoaslureisGrsoiugpned: oSfAfTELfrom necropsy Gross Pathology No NAaLOIsRVrTEoARs,,caKBpRIiADcINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyORoHDEb,AsReErS,vTOeMdSAKCE:HL.ETDAULODMEUNSICNL,E,JESJPULNEUEMN,, ANIDOLDREEDE,HN,ALSAPGALLNIACVNRADERSAY,S,GSLACCNIEDCASUT,NI,CMNACEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRYMNEOGSDLEEAW,NFDE,RTIrCivs,is 655050 Continued on the next page -... _-- oe -- CompanySaniized. DoesnotcontTSaCAiCanll O D TE N b.y- .o. v0 u s, mgSbatoRoe nm --- croviag II TS em. ten Te res ww era onstage a ma ross saotony foTcSSroooosIcrmeLpaiSAncnLa,,m,erTammaaHitesnyieIawnoi,vnEmseeorLcvnnieisndc,e,yuemwiscm.r,rsshwodoowtm,easnnastst,so! ST EL en ries - Eo NTSYioorEurrno,eTcSmTrhmonssaEo,,,SusronasCnt,owoTCam,hO,rusOnhe,oeenuerr,oietSonsonwsmeesm,s,sassnwweioearcm,e,, TSI SaoOo0nNCSpIasi,,;n sBCAoaaevCilesssIsw,)SsDmwemSSSaGonaumnIesi.wma myo,m,swossa,imwso,nt ssopaotons Jhe rienenin Aas, imi CompaSan, oes econ TSACo N 50.DsyOb ral Cy HEE O Suibneartu oenc Tol it CmguinkbDe uoPownss s9478 ~ stor CER4651)Shoomwing anIinmdailvidduaatla afnoirsailndLiivstiidnug animals Dose Group PVT 5 mo/kg/day Sex: Females Aoimal nef Microscopic & Macroscopic Findings casas TKeirlmliendalonSaDcayrif: ic1e75 AxnpiommaalreisGrsoiugpned+ oSfAfTEfrom necropsy Gross Fachotogy Yo MLHaIOcVRrEToRhs,,copKBiIADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyOROHDEb,AsReTSr,TvOeMSdAKCE:HL,ETDALUOWDUESNCTLNE,TSoPyLeEERN,, OAIL0E2DO,NR, SAPLGALTNACVNRADERSAY,S,GLSACCNBIDCASUT,NI,CWANCENORLDVOISNS,,ULAPRREICTTLUUIXMTE,ARRMYENGOSLDESAN,NTDE,RTIHCVHYOREH EGTRLRAUANRDOTLD(LFGALAAILNNDE,,), POSAVYRAEMR(TI8AE)ISR,WOIIUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,RKIINNE,ASROMYPHABAMGLAUARSD,DEER, Sn/AES JOT, STERN, HOSE ~ s;ssost TEKexirplmolinenudarleonGSrDaoacuyrpif: i+c1Se75ATE Animal 35 signed off from necropsy Gross Zachology o MAaLOIcRVrTEoARs.,copGKiRIADcINNEA,YbSm,SoEmLIaUNlNAiGLSt,yCORHoDEb,AsReTSr,vTeOSdMKAE:CLHETADLUGWDOESNCHL,E,ESSPOLNEENN,, NATODLDREEE,N,ALSAEGLALINAVCNARDRESYS,,GSLACCNEIDCRSUF,MI,CYNACEONRLDVOIENB,,ULAPRRISTCROLULYNTN,APRHYMENGOSLDEEAN,NTDE,TRIHCYMLE,ab 655064 Continued on the next page -... ------------------o------ poms eee--e eerrr eeeeeeee Company Saitzed. Doss not contain SOA CB O Sn)RCOB R c)c:ct Duron 0478 ~ sor (RecSrheonwing anIinmdailvidduaatla AFonri.manlaiLviisoteinn)g animate Dose Grow + VE 5 mo/kg/day Sex: pemales amined ret Microscopic i Nacrosopie Findings Gisoea Continued Tron previous pave Gross Pathology : No MGaBTRcHLAYrARRoDVOsIIcODo(/pFLGiBLUcARALNAREDb),,n.orPGBmAVYaRABlAR(iTS3tHE)yYSR,WOoIIbUTDsTHeEGrRLOvUAPeSNTd,DISC:,TNhTGanMAC,HESSS,kmimBnSaoimpienGSuLs,e FERKES JOT, Sram nosy sssoss EKTxeiprlomlsieundraoelnGsbarecoyrwif+i+ 5c4Se00mY Aina 5s Sioned oft from necropsy Gross Pathotoy + --_ No MAILaOLIcREVrTUEoANRs,,,coPBKpRAIiANDcICVNREA,EYbASmS,Go.mLPaCOlNTBiGNSt,yC,oMonGEb,OAsLReOESrN,Tv,OeMSdARKCSEHCL:REUTRDA.LiMwooEscnAi,RTEserere,o BTANHODADYSERR,OLII,DSALGGLALIiRAVnNYADaRR,Y,, GPBSLAYCARBNIA(DNT3SRH),IYRCWOMITWSTDRUH.TBGRYLOLLAPANTRRIrSC.,oNonTapRaatScnaEaSSi .mkomiasieenarsss, FGELANRD K(EPESALJEO)L,T,OVSARrIEaSm,,UTESReUsSs, hGINR, onan Ee Histopathology : No MiKceroowseceopic Abnormality Observed + P --- CompanySaitzed. DossnotconTtSCiACnBI -- DayOraeCavagy eSyinRas _ DDuwpoonmt9a4m78 r ston (ggg 24691/Sheonwing anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group ='VI 5 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 655067 TKeirlmliendalon SDaacyrif: ic94e AEnxipnoaslureisGrsoiugpned: oSf0fDAYfrom necropsy Gross rathology : No MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTrS,TvOeMdSAK:CEHL,ETADLUODMEUNSUCML,E,JESJPULNEUEMN,, AXIDOLDREEUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNEIDCNSUT,MI,CMANCENORLDVOIENB,,ULPARIRETCTULUIYMTM,APHRMYENOSGDLEEAN,NTDE,RTIHCYMULS,b GTPLHHAYANRRDOVIND(KF/GRLLNAAANLRDEY,),, 'OSPVAYARERM(TISKE)YSR,WOIITUDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,RKIINNE,ASROMYPAHAMBGLMUAASDR,DYER, FEMUR/KNEE JOINT, STERNOM, NOSE Histopathology + -- No MiKcIrDoNsEcYoSpic Abnomality Observed: ess087 TKielrlmeidnalonSDaacyrif: ic5e AEnxipmoaslureisGrsoigunped: oSfUfDAYfrom necropsy Gross Pathology : No MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YoS,mSPaILlUNiNAGLtSy,CORHODEb,AsReTrS,vTOeNSdAKCE:HL,ETDAULODMEUNSUCML,E, JESJPULNEGEMN,, ANIDOLRDEEEU,MN,ALSAPGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULARPREICTTULUIYMTM,APRHYMNEOGSDLEEAN,NTDE,TRHIYCMULSo, i 655087 Continued on the next page ... --_ --_--m ae m---- CompanySanitized. DossnotcontTSaCAiCBnI C 2 DyOnN lGavgeSY y veie) covis Dupes --~ sro acneShowing anT imal datp a For ind-- bvibee] anioals Sore cxoUNL 5 mpstarday sex: rensles Sina re Wiorassoria & acrorsopie Findings p= Contimaad Erom previows pare [SS No MFGaiacimnronlosc.o(paPiGEcLARALADEb,),n,orPEGmAUYaAlTKi(IR5t)EyOS,LOibSGBsReCrECvRLeSPdS.R,:hAeTMEaAEC,HESAS,TBhssRooAGBmHeSas,e, Fees Sot, Seam, ot Hietopatheiony --CHRONIC PROGRBSSIVE NEPHROPATHY, minipal. Pe i---------------- =meen --ee GompanySaiz.Doss nocontTSaCAiGnal OX RS0D ODr 1GayvyageOoicdo nRytcsmicO t mpddyinkDpuwa roownss 4m7s8. --_ Shoving anIinmdailvidduaacla AfnoirmailndLiviisdteisnsg animals DsotsoeovGrG oup E VAL4E69N 125fmoom/ko/day Sex: Females pers Wicroscopie Nacroseopis Findings preven EKTxeipriomesidenraelonGsparcaorywi:fi+ coaeS00AY Animal Io signed off Erom necropsy Gross rathology No MSaXOcvNrEToRas,,coBpKRiIADcIVNEA,YbSn,SoPmITaNOlANiGLSc)CyORMODEb,AsReTSr,TvOeWdSAKGEHL:ETALDUMOUDSECRLME, TSaPpLeEErN,, ANIOODDREEEN,,ILSAPGALLNIACVNRADERSAY,S,GLSACCNICDNUSFM,I,CMANCENORLDVOIENB,,ULAPRRSICTTLGOYINMT.PAHRYMNEOGSDLNEAP,NEDRSSHEH. IM:ei GFTIHANARRDOYLID(GF/GELLNAAARNLIDSN,),, PBGAYURAEAR(TTSIE)SR.OWTIDUTTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,KERSU,KRIINNE,ASORPMYHAABMGLAUARSD,DYER, FERKEE OTN, SPER, NOSE Histopathology : ~ KeowgTiHsRONIC PROGRESSIVE NEPHROPATHY, mitral. essorz EKTxeiprlomlsieendraelonGsreboceurypit+i:c5e4S0DAY nEeal To siomed off Eom necropsy Grons patholo No MHaEcOvrReoTns,,copBKiRIAcDINNEA,YbSo,SrPmITaONiNAiGLSc)yCORNODEb,AsReTSr,TvOeMSdAKCEHL,ETDALUOMDUESOCHL.E,IBSseernean,: HTOOLDRBEE,,ALSASGLALINACVNRADERSAY,S,GLSACCNBLDCRSUF,ML,CMANCENORLDVOIENB,,ULAPRRBRCELFUYOIMNAPRHYMENSOGEDoNEP,DE,RTTEH. EL,H 655012 Continued on the next pega... ~ S-- m ----=-- eee --re-- eeeteseeee GompanySaitzed. Doesno contain TSCA Gall EYre i 5 Dros ~~ rsoee cn shoovtintg earnImnedairvi etddual sexs semaLiesIS Animal Listing se Sei ret isroscaria Wenmovioris Finns Gi Cae pean rons sathetony J SrontesCAoD,n,, aSEIoEalnEV)nwEToevSRaaimtcos,wAeCTvHeEenS:,chsR, OnEOS,PTAnCSaE,,nt ET Yo Hiosrrosmcopte Abmormalisy cheered + asso srprsaes suszitign Te Lae cuceupey A D Forroa Eo ire,gTeS oesa,g SW a, eeg deonTs,yswcsucsu,s,Seotvma., TRTnaDgrCaa aATaaaS,, RPRCeCLAAve,Ser,aSiopDo,svuC,LIDRSr,eIicTRTea,sLcwSoG,wms,Nseo=eDrmLoo,mrs es hima, Suasiet)imsors we. skim, want --_ _-------- Company Soad. Doss rtconTtSAiCnBI O 90O.raDlGaavayge c $inyRats oct DuPont0478 ~ Showing aInnidailvidduaatla AfnoirmailndLiviisdtuianlg animals DsotsuenGrgouyp oeVI6IIo215fe/mgn/kg/day Sex: Females Animal Rot Microscopic & Macroscopic Findings assonr KTeirlmliendalonSaDcaryif:ic54e AEnxipmoaslureisGrsoiugnped+ o9f0fDAfYrom necropsy Gross pathology No MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPmILUaNNAlGLiSt,CyORoHDEb,AsReTrS,vFOeNdSAKCE:HL.ETADLUODWEUNSUCML,E, JRSIPULNEOEMN,, ANIDOLDREEEG,HN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNBIDCASUT,NI,CMACNEONRLDVOIENB,.ULAPRREICTTLUUYIMMT,PAHRYMNEOGSDELENA,TDE,RvIiC sL,AH GTBLHHAYANRRDOIIND/(FLGEALMRAAYNLYDEX,):, POEAVYRA3A(RTSIH)EYSR,WOIIUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HERUS,RKIINNE,ASROYMPAHMABGLMUAASDR,DYER, FEMOR/KEE JOT, STERMOM, NOSE Histopathology : ~ No MiIcDroEscSopic Abnormality Observed : sssoss KTeirlnliendalonsDaacyrif: ic5e AEnxipnoaslureisGrsoiugpned: o9f0fDAYfrom necropsy Gross pathology : No aALcOIrRVoTEsARc,,opBKiRIAcDINNEA,YbSn,oSrPImLNUaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E, JESSPULNEGEMN,, NAIODLDEREUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GLSACCNEIDCASUT,NI,CMACNOENLRDVOIENB,,ULAPRREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTIHCUSL.v 655055 Continued on the next page -... -_-- Er `CompanySaniized. Doesnot conTtSaCAiCBnI C 9O0-DaDy yjavc Oage SutudinylRats bcevegeludyinkoDuwPoemnte-9ns47s8 - srvoe (ceoShoring anIinsdailviddueatla ifonrailhLLviLsotuinntg animals sain ot Dose Group : VIII 25Wiamrgo/rkego/pdiaey & WeSreoxu:soFpeimaaleTsintin Fe Cantinesd From previous pee Gross pathotosy : #0 Mafamasr ssatC niSbrr omatinA y WpesH ied ie Gi (FALE), GURNTES, GRERGS, ACen, oBoxsy Han, Peon ee Sori, on es [-- o Npggriasupt Sbesmeliny Shred + essoss TREeeirsmoeivdnaarleonrseabcevreoi't:ic3se75are nat Ta sumed of? fcom necropsy ~ Gross sathotogy No MNaLSociExrmEoomRns,,,copSpEiIaeDcCaNnnDAE,YbnSns:oS,rPimTCAIaNDolGSirStn)Cy,orSonCbEsOsAeLRSrO,iv,ceudSnRrgi:nLe:EThABLoMwoEsckrae,TseeuTys,n NpTFOIAoREROe,LRSDhAtLGILuAA,NiDR,Y CPDAn LERARAoR(88H,)IRWONTa eDDImBGLBVAeLNaADnSRet , NETYAREGEHEnra.nnh,EsSoHmiAGnsSS,, CFieat(eFALsE)o,riGrSReTeESm,OreoRecss. RGR, SREY mabeen, i LO ---- CompanySanized Dos notcontain TSGAGBI UZ5S0b-DysyoOurGalmGgavsegteuRabdiynnkReais 0 101 pDwuorowns4s7s8 --- sor (ghee Srhoonutng anIinmdailvidduaatla AfnoirmailndiLeiisotuinnsg aninals Dose GOMWWUIIE 25 mg/ka/day Sex: Females minal Rot Microscopic & Nacroseopis Fintings Gsioms EKTxieplromlnieandraelonGSraacoyeuipf::ic54e300AY Ainal 3s sighed off from necropsy Gross ethology No MSALaLOIcERVrOTEoHARs,,,coPBpKRAiIANDcICNNREA,EYbRSmS,oS,rPLmICUaNNCAlGLiUStM)Gy,ORWODCbE,OsALeROrS,NTv,OeMdSARKCEE:HLR,EUTDANL OMWUESPCLAE,NTTSPeLi EE,N, FTANEHOOADYERRR,OINDSALGGLLLAIAARVNNAYDDRR,SY,, PGSLASVARCNRAIDT(TS8H)I,YCRWMOIANITENDHRDVIGEOLB,PAUNTLDIAPSCER,TNOEEFRVRSREaRSGNR,HYEnNSco.hnKinIBpS.mPTHaAeGanUrSt, FGELOARD/W(FEERNASLOS)T|,OVASRTIEESR,N,UTERRoUGSs, VAGINA, URINARY mrabeer, sstopathology + PS No Miocvreosrcsopic Abnormality Observed : sssoe0 TEKexirplmolsieundraelonGSrabocaurypi.f1 i+ c1Ne75EEL Aina in signed off from necropsy Gross Pathology Wo MAaILIcOLVrREEoTRs,A,copPBKRiAIANDcICNNREA,EYbASmS,So,PrILsCNUaEANlCGLiUStM,Cy,ORWoDGEb,OAsLNeOTSrN,Tv,OeMSdARKCSA:HLC,EFTODANLUMCEWRUAISCNLLEE,RTGsSap.ipses.t, 655060 Continued onANDtOhRDeE,NnAeLSxAtGLLIpAVaNAnDRySY., GoLSoACNIDNSD,ICWNNEDRTVBEU,LARP.AYTHEPHLnSoema: ae Pe -_---- CompanySantize. Does nocontTSaCAiGanll O XDe ysuO bclonu e Toxicic ty ngNuink oDuwroowne o94s7s8 ~ sor iShnowing anIinmdailvidduaatla afnoirmailndLiviisdteinntg annals Dose GrouPANIIE 55 ng/ko/day Sex: Females aim st Wioromoorie & Wasrossopie Fintinge ee [Ee ------ Gross Fastotosy + No FMGaOAcITrRoDDsRc,o(pPLGiEcLAAARARDLm),,o,rPmBOAYVaA3Ai(NTt8EI)RyRSO.WoZbDUEsTeEGrROLvUPAeSNTd,DZSC:,ANGETRRTVAE,C.HEACS,KRINEA,SOYoPIABaGeOAtSB,RER. FERRE Soe, Sra, moss sss SKtreiprlomrieinraelonGsrsaoceurpyi.:fic58eSUIT Anat Sa sined off from necropey Gross satholony -- No MaIALLicCEvrEUeoRMns,,,coEBpRAiRIRcIDCENRAY,EbSAm,SSo,PmLIaCNGlBACsiLUt,MCy,ORWODCbE,sONeLTrSO,vT,OeMSdARKCEE:HLC:ERTNAD,LUNNDEUSSECELN,EF,ERTLSLoeLsLEmo,,w ETNOV0OaR8OR,LEDSACCLAAIaRVNADNIR,,,Y PGSBALYCSaEIAD(AI3STI,)IICRWODINIATEDBRHVSGELOL,APANTRDIBS,CE,RONFTETIRRRSVARECY,K.ESROSG.RKoEIn,DReB:SRWiAAAGLUA,SR, PGElOaN (FEESMAoLET),,CVASRTSEESR,N,UTERRoURS, VAGINA, RINARY SeabSER, tstopathoton + #0 Niogvzeosrcsopte Abmommalisy Observed : se--e =Ln eer se mam s -- CompanySante. DossnotcontainTSCA Gal --int-- en Dnsrs ~ sve (SM2ec9S1hoo,nwing antaat docs for iad-- ivioual annals Dose Group mina sat : VIII 25 mg/kg/day Sierorsopia 4 Sex: Females Heceeneopia Frit FA Eeerrodmriuenraenl.dFrabocevrroi't5:ic1e3008Y Ena Te rumod 208 trom necropsy Gross pathotovy : No NE aosvreonn,copKiIcD.NEAYbe Sn,ormTaIlNiSt)y JOEbAsReTr,voeeSdKE:LETe AL MUeSCLE,aSPL:EEN, NTTooEomna,nSooCrmnLcAeaiSsn.s,SSaCEmIEaeicKTCEoARtRoR.n ASArTCOTIRoR.aREReEGSoIonAnT:EpLoSteL,o CTfirEROiR Ci p, FA RGATIROTS CLANS, TRACET R RooPe HAGLS, SE eri Sram, oes iocopathotons + ~ p--ERRONTC PROGRESSIVE NEPRORATHY, mininal. sssors ErI emeaeaaree:nh--aperrp'--+:50Sony Sa sumed S08 com necropsy Gross Pathology + 5 NRoEocvnreeonns,,copSFtieeeavA:iem,oSmemTarOlNiiSv,CyoMonEbnAsReESr,viecSduKGi:hL:ETADLOSRciNe, Tseenu,, 655078 Continued onprToLheEir,miPpeRmEeSeay, niCotoinn. SnogLon,gSCOR, EoOdRrpEaRSeE dLet ~ --_-- Company Saiized, Doos not contain TSCA GBI 20 Or C1 avesStyScnhhso.n Toy Duronusrs ~ DsotsoeveGgroloOoVILcE 2s5fShesmonow/iknag/caanIyinoadlidcaSetaxa: afnoirmaSlndiLviisdteinnsg Females animals Reina sat Hicroscopic & Hacraseopis Findines Pn [---------- Gross patholo + No MGaETcHIArIoRARsOcILoD(pPiAGEcLARALAEDb),,m,orPGBmAUa3AiTR5iTRc)EyOS.ALO1bSU7sT4eErGROLvUaePSNdE,DSs:,VANGETIRRNVAAEC,.HEAOS,hRavBAeSSoomASaGeDaSt,ms, FERRE Som, STERN, NOOR Histopathotos : ETCHRONIC PROGRESSIVE NEPIRORATHY, minis. ssson EKTxeiprTomTnieunaraelonGsDaracoyrwit1 i: c1e7s5xe AE Ta siomes off From necrepey ~ Gross patholo + No NRaILOIcLRVrTEEoARs,,,coTpKBiRRIADcWINRNEAE,YbASmS,So,rELmCINaNRGGiEScM)Cy,ORMODCEb,OAsLReOESrN,Hv,OeNdSARKGBE:HGC:ETTNDA,LONwoOsEcRLeO,TNseLSpmo,i FTANOHDADRRERO,EAISDSRTCGLLIALVARAADESR,Y,, rGBASLSC3AIA5NTSTE),EYCRWOVINTATEDNHRDVGIEOBi:FInTLgEAPGRL.rNLUEcYRRHRhVPREeHR,YnT.SGOBheEin,Svio,tmwneeuans,n E GLADa(PALE), GUAREES. GTERGS, VRGNA, ORAS ana, ~ --_-- ee CompanySaitzed. DocsnotcontTSaCAiCanl C 9D0.DuayOOnrallCGwavgaegeduSY tduyyivinn kRaactss Toit DuDuoPworot9a4n78s ~ Showing anIinndailvidduaatla AfnoirmailndiLviisdtuianlg animals Stoo. ico: en Dose Group : VIII 25 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings ess082 KTeirlmliendalonsaDcary:ific1e75 AEnxipmoaslureisGrsoiugnped: oSfAfTELfrom necropsy Gross sathology : Yo MAaLOIcRVrTEoARs,,copBKiRIAcDINNEA,YbSm,SoPmLIaUNlNAiGLSt,yCORHODEb,AsReTrS,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E, JESIPULNEGEMN,, ANIODLDREEUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULAPRREICTTLUOYIMMT,PAHRMYENGOSLDEAENN,TDE,TRHIOCMULSY,MPH GPTLHHAAYNRRVDOIIUD(/FLGEALMRAAYNLNDE,X),, POEAVYRA2AR(TI5H)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,KRITNNS,ASORPMYHAABMGLAUARSD,DYER, SEMUR/XVES JOTI, STERNOM, NOSE sss085 ~ KTielrlmeidnalon SaDcayrif: ic54e Exposure Group : S0DAY Animal is signed off from necropsy Gross pathology No MAaLOIcRVrTEoARs,,coBpKRiIADcINNEA,YbSn,oSrPImLNUaNAlGLiSt,CyOROHDEb,AsReTSr,TvOeMdSAKCEHL,ETDAULODMEUNSGCML,E,JESJPULNEUEMN,, ANIDOLDREEEU,MN,A|LSAPGALLNIACVNRADERSAY,S,GSLACCNEIDCMSUT,MI,CNNACEONRLDVOIENS,,ULAPRREICTTLUUYIMWT,PAHRYMNEOGSDLEEAN,NTDE,RTIHCYULSY.MPH 655085 Continued on the next page .... --~ -_-- ee =e `Company Sanitized. Dossnotcontain TSCA CBI A 0-Day Oral GY avage Study in: Rats Toc DuPont9478 ~ Showing anTinmdailvidduaatla AfnoirnailndiLviisdtuianlg animals sDotsoerGr(ouEp)2V4II6I 9251fom/ng/kg/day Sex: Females Aniral Ref Microscopic & Macroscopic Findings 655085 Continued from previous page Gross Pathology : No Ma`TcHrYoRsOcIoDpGiLcANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, ESOPHAGUS, GPLHAANRDVI/(FLEAMRANLENSX),, OEVYAER(ISE)S,WIUTTHEROUPST,ICVANGEIRNVAE,, USRKIINN,ARMYAMBLMAADRDYER, FEMUR/KNEE JOINT, STERNIM, NOSE Histopathology No MiKcIDrNoEsYcSopic Abnormality Observed : 655105 TKeirlmliendalonSDaacyrif: ic94e AEnxipmoaslureisGrsoiugpned: S0DAY off from necropsy ~ Gross pathology : No MaLIcVrEoRs,copKiIDcNEAYbSn,ormLUaNlGiSt,y OHEbAsReTr,veSdKE: LETAL MUSCLE, SPLEEN, AIOLRETUAM,, BPRAANICNR,EASS,PICNACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UODMEENSUEMN,TERJIECJUNLUYMM,PH NAODDREE,NALSAGLLIAVNADRSY, GLSACNIDAST,IC`MNAENRDVIEB,ULPARITLUYIMTPAHRYNOGDLEA,ND,TWAMUS, TPHHAYRRYOIIXD/LGALRAYNNDK,, `BBYASRM(TSH)YRWOIITDHGLOAPNTDISC,NETRRVAEC,HEAS,KINS,SOMPHAAMGMUASR,Y GFRLMAUNRD/K(NFEEEMALJEO)I,NT,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, 655105 Continued on the next page .... -- _-- -------- TE CompanySanitized. Does notcontTSaCAiCnBI Commm-- 9-Day Oral Gavage SuindRcaytisc Toi ~~ Showing anIinmdailvidduaatla AfnorimailndiLviisdtuianlg animals sDtouspeyGroup : ViIIcIo25cmng/kg/day Sex: Females aninal Ref Microscopic & Macroscopic Findings 655105 Continued from previous page Histopathology No MiKcIDrNoEsYcSopic Abnormality Observed : DuPont.9478 --~ --~ --- Company Sanitized. Does not contain TSCA CBI O 90OnlGDec , sh cts Dirosis ~ SsoOe Camis ieschosvirng nsiigtivsieeatxehspioBsssessIToTries ise Somer re Raecescepia' Taeroscopis Fiions Ge ESdHoniPsironinsmecraaisiycSeB os swinonny . acons sachotony JE re ees Tones,S Soe Sia van a scr,I y seu, E I DE E a lt, EEE e Tne S-- TM PcLIVanERmir": sas,saaOtn,AtsSnooSn,AseAatoTsts REPS LA --_ _-- Company Sait. Dossnotconsi TSGAGS! COs M n << ity pars - uns SCSatTividun aVnEimRIisLinYg ores ssrooorO (246C 1,om cee pemnien Semana wastes aon NE S NT T a ETAA,SST 00 FERN Ca ov,ThsSmm ,nt L cs fst. DL hSekoSn y uk. Ban am yy BA A RT TR R SE eres ~-- sv eT agaaiegte Nr AA SisitAaoLm,JoTeei,.regmri,r, BPEE Dy T ee m a agen --_ Company Sac,Dossro containTSoACB! C IO.ci pm ~ spate SI TE SBI ions sor pci ecen ey son: zemnies a Se Continand oan peavions sone siroastotony feilies rpemasses semis, stot A dezee B Sopa E serisiceWnye cessive crore pathos - Yo NS aceoseopI ie Nimoreae tisy AchsEervedLhai sE a. e sya E EE T a I ak RE D El T a aT, jyrani Svsoretcinnsy winpees --_ --_ mmm --m Company Satz, ons etsemanTSCAGE! r MCy err onu o 0 cwtognre oDwues pso - sroor Ecco: iSohonrty SIonadirvideuatl aTnimAal ListIing tents oreo I ovnarcay su memes wim vat Niroseapte & maceoscopte Findings sistepathotony : comerCs R ONE EE Rinia Yo NiCvcooxno,sscoSHpoatscnannA,i,moSr"EDmoaLclbEimtSnygnWobSshereeverdst: iSme,asoem, amA,saSeenin f a rEa i R Btaidi ea eSSAaaLaLesY aCLtAhDE. CTinEaRtLs.aSteCmmseRtEmE:2SSepeawtencanu S(roams), esorza --_ eTPermeienal easatcreiteicsre or ERs Tom crepe B BoSrEEnE RE SrimT oentisn,s,TCOaNtGoSn,E ,S-- CEoAuRn Sehckeoam. cwVosckrzS,SsreLuEhsa,.p feetSe RT c ag on mopar ALCLH 655028 Contiouad on, the next page ~ AST, Company Sanitized. Do note conts ain TSCA C81 O LSD0DyaOynR OlraGluGuaY vgasgeSSu. dyyiinnR. Ratass0 1.c Dwupoown9o4s78s ~ soe (IRass1,Sfheonwing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals Dose Gioup * X 125 mg/kg/day Sex: Females Ania nef Microscopic & Macroscopic Findings Gs5024 Continued from previous page Gross Pathology : Yo MaTPcHHrYAoRRsOVcIIoD/pZiGcLAARNAYDbY,n,orPEmAYaRElA(iTStH)yYRWOoIIbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINB,SOMPAHMAMGASR,Y GFELNAUNRD/K(IFEEEVAJLOEI)N,T,GVSATREIRENSO,M,UTENROUSSE, VAGINA, CRIWARY BLADDER, sss026 TKeirlmliendalonsDaacyrif: ic94e AEnxipnoaslureisGrsoigunped: oSf0fDAYfrom necropsy Gross Pathology : No MAaLOIcRVrTEoARs,,copKBRiIADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,GTDAULODMEUNSGCMLE,, JESPSLUENmMy,, ~ NAIODLDREEGE,HI,AL`SPAGALLNIACVNRADERSAY,S,GSLCCAIENCADUT,MI,CMANCENORLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE.TRIHCYMLE,b GTFLHHAYANRRDOIINDK(F/GELLMAAARNLDDEY,),, `EOPYVAEAR(RMSTI)HEYSR,WOIITUDTHEGRLOUAPSNT,DISC.VANGETIRRNVAAEC,,HEAUS,RKIINNE,ASORPMYHAAMBGLMUAASDR,DYER, PRNUR/RNEE JOINT, STERN, NOSE Histopathology : LovenHIYNPFELRAPMLMAASTIIAO,N, BISLUEBADCUUCTTE,/CHmRiOnNiImCa,l. minimal. 655026 Continued on' the next page. _-- TE Company Sanitzed. DossnotcontainTSCA G81 C 5O0bD1O yOrnailG. uaavaggeS. eSudtyinn. RRaets oDwupwonoc9s47s8 ~ sor Qc Scheowning anIinmdailvidduaacla AfonrimiandLiivstiidnug aninals Dose Group % 125 ma/kg/day Sex: Females Sind Ref Microscopic & Nacroscapic Findings prevent Continued from previous page sistopashology + xaoveCrHsRO+NIC ZROGRESSIVE NEPHROPATHY, minimal. Yo MCiLOUcRNrDGo,Ss,coSTpHOEiNAcRATCA,Eb,noSrKDmEUaLOlEDiTEtAyLR,MOUbSSsCEeLrIEvT,eHdNS,P:LETELN,E,AORPTRAR,CREBRRSA,IN,CeSoP,raL MNCAEONRLDVOIENB,,ULRPAEIRCT.TUOLIMNTY,ANREYMEGNSLOEADNNETD,E,RITTCHYRMLUYOSM,PDHAGNDLORADENEND,A,LSGASLLAAERNVNDASRR,EROGSSLCDArNvDemGis.ca, OTEVYRAEAR(C5IH)EES,,WIUTTEHSEOROPUPASTA,IGCUSU,RNEIRNFVAERR,YAISSAKLDND,AERRWV,IA,FREUYR/GFLNAENSD S(oFmRmOeA.LE,) STERN, BONE MARROW, OSE sss027 -- KTeirlmliendalonsaDcaryif:ic1e75 Exposure Group. + SATEL Animal is signed off from necropsy Gross Fachotogy Yo MALaIOcVRrEToRAs,.copKBRiIADcINNEA,YbSo,SrPmLIaUNlNAiGLSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODMEUNSUCML,E,JSSP0LNEERN,, NAIODLDEREUE,NN,ALSAPGLALINACVNRADERSAY,S,GSLEACNIBDCNSUF,NI,CWACNEONRLDVOIENB,,ULAPRRIETCLTUUIIMNT,EAARYNNESOGEDLNEAP,NSDR,PZGA. LL.v 655027 Continued on the next page .... -- -_-- CompanySarid. DossnotcontaTSiCnA Gal C 50 DayOO nlGuM aSgyesM iin tec. ) ovicity Duron 478 ~ sro OTEShowing anIinmdailvidduaatla AfnoirmailndiLviisdteien)g aninals Dose Group + 125 mg/kg/day Sex: Females presrgh Wicroscopic Wacroseepis Findings Ssioz7 Continued from previews page Gross Fachotogy : Yo M"aFcHTrAHoRsRTcORo/pLGiLcAARNAYDbN,n,orFEmAYaRBlN(iT3tA)yROWOTIbTDsHeGrOLvPAeNTdDISC:,NETRRVAEC,HEAS,KIENSOPaEAsGUtS, GFLEAMDR/(KFIENASLOE)T,OVASRTIEESR,N,GTENRODSSE, VAGINA, URINARY BEADSER, essos0 KETxieplrolmmeiundzaelonGsraaocyurpif: i+c1Re83ECOV Sima 55 signed off trom necropsy Gross pathology : --~ No MAaLOIcRVzTEoARs.,copBKRiIAcDINNEA,YbSn,oSrPLmIUaNNAlGLiSt,CyOROWDbE,sAeNrS,vTOeMSdAKCE:HL,ETDAULODMEUNSICML,E, TeSPsLtEhEmN,, TEN, PANCREAS, CECOM, COLOV, RECTUM, NESENFENEE Lib ATNHOCDYERR,OIEDSAGGLLLIAAVNNADDR,SY, GLSEAACNRINDATSTA,IICRMOANIENDRDVIGELB,AUNLDAPSRI,TLUTYIRMTAPACHRHYENNGO.RLEA,BDS.SOPtAGeU,S, ERGPALERATDRIK(ETFIARNRAYLJENO),,T,EGYUEAS(RTSIE)ESR.WNI,TUTHEHROoUPHST,ICVANGEIRNVAE,. USRKIINN.ARMY aSenaDteER, Histopatholony : 635030 ContinueLdavoenn`:itGhTeECmTeAeStTSp,ageminimal. PS -- a CompanySantzed DoesnotcontTSaCAiCanll C EOh Y nlGy a. g io sy. nfu o. . 0 eaptayinkpe Dwuerwonos onus7s ~ sor Oca: Sheonwing anSiumdailvidduaacla afonri"nanldivviisoteinntg animals Dose Group 125 makg/dey Sex: emsies permeg Wicroscopie & Masroseaie Finite Gian Continued tron previous pean Histopathoto : xaoweF RsON EASE TS, BYE-- AE Rntier sss037 TKSeeirpTmriieensdaclsonOSabvacyre.i:fic19Be3eco Ena Fivme ott ron necropsy Gross zasholosy : No MRaLTOIcHNVrEeEoNRs,,,copKESiINEDcCANRREAE,YbnSnS,So,rrmLmiCOaNAalGGicSto)Cy,oNonCEb,ROsWLeEBrO,vrReoGduRRRR:RL:ERT.DALiWMooScSnLE,RTseeiosa,n ~ FAANTODRREEO, ,LSAEGGLLAiARANYnRDR;Y,, GPESAYCLRBIT(A,A5T)FIRCOWOLMNiEEBREGGBEPLS.AETRRAPECRe,TNoa nEeeRnYrCkaomnaDmSbaeAhsGrrSt, FGLeAaD K(sFEsWASLSo)t,i,OVASReEReSn, ,GTEmRUaS: TAG, VARA menage, istopathotony : even`eLBTION, SUBACUTS/CERONIC, minipal. No Mipcroascopic Amermality observed : -_-- Company Sanizsd Doss not contain TSCA GBI C 0-Day OrO al Gavage SM ty invRaots) c icy DuPont.9478 ~ Showing aInnidiavidduaacla AfnoirmailndLiviisdtuianlg animals Dsotsoe:Gr(owpN:aX 6125snfg1/ekna/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 655045 TKeirlmliendalonsDaacryif: ic1e75 AEnxipmoaslureisGrsoiugnped: oSfAfTELfron necropsy Gross Pathology Yo MAaLOIcRVrTEoARs,,coKBpRIiADcINNEA,YbSn,oSrPLImUNaNAlGLiSt,CyORHODEb,AsReTSr,TvOeMdSAKCE:HL,ETDAULODWEUNSGCML,E,JESTPULNEOENN., NAIODLDREEUE,MN,AL`SPAGALLNIACVNRADERSAY,S,GSLACCNEIDCASUT,MI,CWNACEONRLDVOIENB,,ULPARIRETCTULUIYMT,AMRYMNEGOSDLEEAN,NTDE,TRIHCOULSY,MPH GTPLHHAAYNRRYDONIKD(/FLGEALMRAAYNLIDE),X,, `EOPYVAEAR(RASTIH)EYSR,WOIIUTDTHEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,RKIINNE,ASROMYPAHAMBGMLUAASDR,DYER, FEMUR/KNEE OOINT, STERNGM, NOSE 655049 ~~ TKielrlneidnalonSDaacyrif: ic18e3 Exposure Group : RECOV Animal is signed off from necropsy Gross Pathology : Yo MAaLOIcRVrTEoARs,,coBpKRiIAcDINNEA,YbSn,SoPrILmNUaNAlGLiSt,CyORGHDEb,AsReTrS,vTOeNdSAKCE:HL,ETDAULODMEUNSUCNL,E,JESJPULNEUEMN,, ANIDOLDREEUE,MN,ALSAPGLALINAVCNRADERSAY,S,GLSACCNIEDCASUT,MI,CMNACEONRLDVOIENB,,ULPARIRETCTULUIYMTN,APHRYMNEGOSDLEEAN,NTDE,TRIHCYMLUYSMPH 655049 Continued on the next page -... ~~ -- ws CompanySanitized. Does notcontain TSCA GBI CS S 90.DayDOral u GavagoOSN yu in Ravtl iscToxG ic upesoyinRDwue poonwt9s s478 ~ Showing anIinmdailviddautael AfnoirmailndiLviisdtuisnlg animals DsotsoerGr(oupe 6X 91251msg)e/kmg/day Sex: Females Aninal Ref Hicroscopic & Nacroscopic Findings as5045 Continued from previous page Gross pathology : No MGPTaLHHcAAYrNRRoADOsDIcSDo(/pFLGiEALcMRAAYNALNDtEK,o),|rBmOEAaVYRlASARi(TIStHE)yYSR,WOOIIbTUDsTHeEGrRLOvUAPeSNTd,DISC:,VANGATIRRNVAAEC,,HEAUS,RKIINNB,ASROMYPHuBAbGLOUARSD,DtER, FENUR/KNES JOTHT, STERN, NOSE Histopathology L1veRHDYIPFELRMPLAATSIIOAN,, BISLUEBADCUUCTTE,/CmHiRnOiNmICa,l. minimal Yo MiIcwroYscsopic Abnormality Observed : - as5052 TKeirlmliendalon sDaacry:ific54e AEnxipmoaslureisGsriogunped: oSf0f0AYfrom necropsy Gross pathology : No MIALaUOIcERVrUTEoNARs,!,coBPKpRAIiANDcICNNREA,EYbASnS,So,PrILmCUNaNAElGLiCStU,Cy,ORHODCEb,OAsLReOTSrN,Tv,OeMSdARKCEE:HCL,TEUTMDA,ULODMMEUENSSUCEMLN.EF,ERoISCseueLMm.i,bH 655052 Continued onANODtDhREeE,NnA|eLSxAtGLLIpAVNAaDRgSYe,.GSL.AC.NIDNST,ICMNAENRDVIEB,ULAPRITLUYIMTPAHRYNOGDLEA,ND.Tvs, ~ E-- E Company Sanitized. Dossnotcontain TSCA 081 (-- vigSdSubincRtortos.ncToxicity Duron s475 -- stor (RE) 24651,Sfhoonwing anIinmdailviddautaal faonrimailndLiivsitaiunag animate Dose Group: X 125 mokg/day Sex: Females Sainal Rat Microscopic & Macroscopic Findings Gsosz Continued from previous page Gross Pacholosy : No MG`EaTcLRHrAAYoRRDsOIcINoD(p/FGiELLcNAAANRLADSbI,)n,,orEOZmAVRaVANl(RTiSIHt)EYySR,WOOIZbOT>sTHeEGrRLOvUAPeSNTd,DISC:,VANGETIRRNVAAEC,.HEAOS,KRIINEA.SROYPJHaAasGneUsSc,te, FREE Jom, STERNH, ROSS Histopathology KLaovevnFaLAGITION, SURACUTE/CHRONIC, minimal. AREAMCLIHNREGORLNAAILNCIDZSZARTOIGORNE,SSmIiVnEimNaElPHROPATHY, minimal. -- No MCiSOOcRNrDGo,Ss,cSoTHpOiENcAATCa,Hb,moSDrKUEmLaOSlDTiEAcNLyI,WOObSsCSeLBrESv,UeNdNS,P:LELEENC,H.AORTBAA,NREBRRGA.IN,SSaPINAL MGECLSAOAONLNPODDHNI,A,SGUULTRSAHE,RYCTRUOLPMIHY,DAREGMYLEGAKS/NOELDDNA,ETR,EIRPNTIAKCRO,AUTLSEHYYYW,EAF(OH3TS)DCOIDWGAERTE:AATNCDASON.PLETRIFYSCR.YAWCPaHAEse.,eaSkKIN, MFAOEDRNY GGLAJDOTI(F,IMSALTSE),RNO,VARBIOENSE,iUToERnUS.NoOsRsSARY AS --_ --- Company Sanitized. Doss ot containTSCA GBI SC -Di OraO lGavage t) oyinRats. sic DuPont9478 -- stove ()24691Sfhe/onwing anIinmdailviddautaal AfnoirmailndLiviisdtuianlg anisals Dose Group: X 125 mg/kg/day Sex: Females Aniral Ref Wicroscopic & Hacroscopic Findings 655053 KTeirlmliendalonSDaacyrif: ic54e AEnxipmoasluriesGrsoigunped: oSf0fmafYrom necropsy Gross pathology : No MAaILOLIcREVrUTEoMARs,,,coPpBKARiINADcCINRNEA,EYbASmS,oS,rPLImCUNaBNAlCGLiUStN,Cy,ORHODCEb,OAsLReOTSrN,Tv,OeMdSARKCEE:HCL,TEUTMDA,ULODMWEEUNSSGCENLN,EF,EJRIESC0eUiLNosMm,b.it PTANOHDHDYRAERER,ONIIANDLSNA/GGLLLLIAAAVRNNAIDDRO,SY,, `GBPLSYAAC3RNI(MDATSSTH),IYCRWMOINAITENDRHDVGIEOLB,PAUNTLDIAPSCRI,TNLUETYXRRMTVAPAECHR,KYENROSG,DKLEIAN,NE,DS.OHMPvAHiMAGMsUA,SR,Y FGRLIAUDR/K(NFEESKALJEO)T.I,OVASRTIESSR,N,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology : --_ sLoevaemnI::NFLATION, SUBACUTE/CHRONIC, minimal. CARDIOMYOPATHY, minimal. Mo MCiSKEIcPCDIrUNNoNEAs,YLcSo,CCpOOiLRLcODU.NNA,GbSn`,SRoTErOCSmMTKaAUElCMHLi,,EtTyMADELUoSObEDMsNEUeNTSrUCEvNLRe,EId,C`:JLSEYEJLMUEPNEHUNM,,SOAIEOL,RETGANS,,ALIBPVRAAANIRCNRY,EAS, SGLCAINADTSI,C NWEARNVDEI,SULPAIRTULIYTMAPRHY GNOLDAEN,D, TTHYHMYURSO,IDADGLRAENNDA.L GLANDS, 655053 Continued on the next page .... --~ EE -- Company Sanized. Does not contain TSCA CBI O5R 0OnaDGavaageStyudy inRatvsic Toc Duponcs47s ~ soo (EER)46s)Shfoowming anIinmdailvidduaatla AfnoirmailndiLviisdtuianlg animals Dose Group * X 125 mg/kg/day Sex: Females Animal Ref Microscopic & Macroscopic Findings 653053 Continued from previous page statopathology No MiPEYcAErR(oMSsT)cIoRWpOIiLTcDHALObPnAToDIrSCma,NlEiRTtVRyEA,COHbESsAKe,IrNv,SeSdWOPA:HMAAGRUSY,GLPAHDA.RI(UFLE/VLAALREY), OSVTAERRINEUSM,, UBTOENREUSN,ARRUORWI,NARNYOSEBLADSER, FEMUR/RNES JOINT. sssoe1 KTeirlmliendalonSaDcary:ific1e63 AEnxipmoaslureiaGrsoiugpn.ed: RofEfCOfVrom necropsy Gross pathology : No MAaLOIcRVrTEoARs,,copBKRiIADcTNNEA,YbSn,SoPmILaNUlNAiGLSt.CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETADLUODMEUNSGCHL,E,JESSPOLNEOEMN,, ~~ NATIODHLDERYEUER,MNO,AILDSAPGGLALLINAACVNNRADDER,SAY,S,GPLASACRCNEIADCATSUTH,MIY,CROMNIACEDONRLDVOGIENLB,,AUNLDARPSREI,CTTLUUTYIMRNT,APACHRHYMENEROGS,DLEEAN,NTSDES,ROTPIHHCYAMGULSUY,SM,PH GFPELHMAAUNRRDY/IRG(I/FELEEAMRAGYLONET,),H,OEVYAESR(TISEE)RSM,GWMI,UTTHENROOUSPSET,ICVANGEIRNVAE,, USRKIINN,ARMYAMBLMAADRDYER, Histopathology 635061 ContinueLd1veonmItNhFeLAnMMeAxTtIOpNa,geSUBACUTE/CHRONIC, minial. --_ E--e eer eee eeee a eeeeee eee Company Sanitizad. Doos not contain TSCA O81 DowageOSw tin RaytsCwgedodyinRbDwe ueonwe9os 4s78s ~ Showing anIinmdailvidduaatla AfnoirmailndLiviisdtuianlg animals DsotsoerGr(ou2p:4X 61259nfo1e/kng/day Sex: Females Animal Ref Microscopic & Macroscopic Findings a55061 Continued from previous page tstopathology xaowgyCsHRONIC PROGRESSIVE NEPHROPATHY, minimal. 655063 KTeirlmliendalonsDaacyrif: ic54e AEnxipnoaslureisGrsoigunped: oSf0fDAfYrom necropsy Gross Pathology Ho MALaOIcRVrTEoARs,,coBKpRIiADcINNEA,YbSn,oSrPLmIOaNNAlGLiSt,CyORHODEb,AsReTrS,TvOeMSdAKCE:HL,ETDAULODWEUNSUCML,E,JESIPULNEUENN,, . ANIODLDREEEG,NN,ASLAPGLALINACVNRADERSAY,S,GSLACCNEIDCNSUT,NI,CMNACEONRLDVOIENB,.ULPRAEIRCTTULUIYMTM,APHRMYENGOSLDEAENN,TDE,RTIHC sLv.itpi ~ GTPLHHAYANRRDONIXD/(FLGEALMRAAYNLNDEK,),, POEAVYRAENR(TSIH)EYSR,WOIITUDHTEGRLOUAPSNT,DISC,VANGETIRRNVAAEC,,HEAUS,KRIINNS,ASORPMYHAAMBGLMUAASDR,DYER, FEMUR/ANE JOTI, STERN, NOSE #istopatholosy LaveRINFLATION, xIoNEYS : SUSACUTE/CHRONIC, mininal. SKELETCAHLROMNUISCCLPEROG: RESSIVE NEPHROPATAY, minimal. 655063 Continued onTNthFeLANnNeAxTtIOpNa,geSU.B.ACUTE/CHRONIC, minimal. --_ r----ri----------oeeerieenseeem-- Company Sanized. Dossnot contain TSCA GBI OD C Do ).e y ..ovc,uGrsumpeDe wrsos ~ Showing amIioetautridainyt rSaatLyisLuing sor pcos Dose Group : X 125 mg/kg/day Sex: Females Sn Convimees From penis -- J A E EEE am. IE r i oehSe oSeSeosngSSoAnaeSrEyvSe,,d sSOoolEii,.,Sc(oo0muo,,k,SSrRovwecaccsor,, Taa EE,ETa roP EL DaSaa seaScopNesiipaOyaISnSDCL,LAACLDMLLEAA,SRDSALEaSvCTeLIAO,SCELrIAaEUSsLo,n po PN m SeeeL no,tom necrenny isa sash + TaSToirnenug , TTDhiasraB,ens,UASTao,nLs!SodSNonee,erSTeEelASdaCiHmst,a BaWUSwCsLSci.,s,TSsrseiisosm,., Ea E a me -- reer e sesar me Company Sates. Boos otcatTSaAGnB (--I -- icnhoai Tvicy Dromore ~ OUME....S..dxp oiafl JrAgNFA cSeoisd ON sro (EDiotn er sex: semates perme Siaroscopie Racrosopie Findings Fon Sontinasa von previoes ave cross athlon o NapcrroRascEopCRiocraaAgbmn.orRSmoaaltiae t)y WObigsmerCvetode: NEE, BKIn-- : MovORT Sentea ySot,BoSarsa,m,DYwEoRoSs. AGI, URINARY BLADDER, Msspuiniogy + J JSAPLABATION, SUBACUTE/CHRONIC, minimal. ESRNIC. ROGRESSIVE NEPHROPATHY, mininal ssso _ Emnerreomvieanranel Gsuoecrrroi'ti+c1s0R3BcoV abet off from necropsy dens Sahrteny + Wo MoFacroroinscsopLtieocmunArbsn,orTmaOlNit.y A, Deena Saco. ODIbAsReFr,dvehdSsKEgLETAtL WIoSCLE, SPLEEN, Coun. RoR, WESENREREC Lie EftrettrsaeShiago. roSaRSgBARR . THhrMODE, TAS, 635077 continued on the next page -.- _ or Gompany Saniized Doss not containTSCA GBI ("S Day OraY l Gava) ge iiyRatsic7c Dupont 9476 -- Individual Animal Listing soy QEEBY246sSf1heo)nwing animal data for individual animals Dose Group NX 125 mg/kg/day Sex: Females Aninal Ret Microscopic & Macroscopic Findings assom7 Continued rom previous page Gross pathology : Yo M`aTcHrYoRsOcIoDpGiLcANADb,noFmAaRlAiTtHyYROOZbDseGrLvAeNdDS:, PHARYIGH/LARY, EYE(S) WITH OPTIC NETRRVAEC,HEAS,KINE,SOPMHAAMGMUASR,Y GFELNAUNRD/K(NFEESMAJLOET),NT,OVASRTIEERSN,OM,UTENROUSSE, VAGINA, URINARY BLADDER, Histopathology Lem`INFLATION, SUBACUTE/CHRONIC, minimal. KeoweAeNGI:ECTASIS, minimal. CHRONIC SROGRESSIVE NEPHROPATHY, minial. -- ss5084 TKeirlmliendalonSDaacyrif: ic1e63 AEnxipmoanlureisGrsoiugpned: RofEfCOVfrom necropsy Gross pathology : Yo MaLAIOcVRrEToRAs,,copKBiRIADcINNEA,YbSm,SoPrILmNUaNAlGLiSt,CyOROHDEb,AsReTSr,TvOeMSdAKCE:HL,ETADLUODWEUNSGCML,Z, JRSIPULNEOENN,, NAIODLDREEUE,NN,ALSAPGLALNIACVNRADERSAY,S,GLSACCNEIDCASUT,MI,CMNACEONRLDVOIENB,,ULARPREICTTLUUYIMMT,PAHRYMNEOGSDLEEAN,NTDE,RTIECMSi,vi 655084 Continued on the next page -... --~ - wm `CompanySanitized. Dossnot conTtSaCAiCnB SO 0.DayOral GR aveSty inR: atsic Toxics DuPom 478 --~ Showing anIinzdailvidduaatla AfnoirmailndLiivsitciunagl animals sDTouspeYGroup X c12o5 imgn/kg/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings assosa Continued fron previous page Gross pathology Yo MaBTcHArIRoRIsONcIGoDpLiGcLAARNADYb,n,oPrAEmYRaEAl(TiSHt)YyRWOOIIbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPMHOAMGDUASR,Y GFLEAMNUDR/K(NFEEEWALJEO),T,OVASRTIEERSN,UM,UTENROUSSE, VAGINA, URINARY BLADDER, stacopatholosy: LavenEATTY CHANGE, MEDIAN CLEFT, mild. KoonCsHR:ONIC PROGRESSIVE NEPHROPATHY, minimal. essoss KTeirlmliendalonSDaacryif: ic18e3 ~ AEnxipmoaslureisGrsoigunped+ oRfEfCOfVrom necropsy Gross pathology : No MLAaIGcVRrEToRAs,,copKBRiIADcLNNEA,YbSn,SoPrLImUNaNAlGLiSt,CyOROHDEb,AsReTSr,TvOeMSdAKCE:HL,STDAULODMEUNSUCML,E,JESJPULNEUEMN,, NIOLDEEO,N, `SPAALNICVRAERAYS,GLACNHDUSN,,MACNOLDOINB,ULARRECTLUYMN,PHMNEOSDEEN,PRTIiCvuvLsv.upi ADRENAL GLANDS, SCINTIC NERVE, PITUITARY GLAND, 655088 Continued on the next page .... --~ -- Company Santzed. DoesnotcontTSaCAiCBnI ORDayOnlGavage PoinlRays oc DuPont978 --~ Showing anIinmdailvidduaatla AfnoirmailndLiivsitduianlg animals stove QDasssfe1n Dose Group : X 125 mg/kg/day Sex: Females nina Ref Microscopic & Nacroscopic Findings Gssose Continued trom previous page Gross pathology No TM"aHHcerRvoaosTcDo.pGiCLcAARNADbI,n,orPEmATaRElAiT(tH)yYRWOOIbITsDHeGrLOvAPeNTdDISC, NTEHRVAEC,HERS,KINE,SOPMHAAGRUSY, CTiEnNaU(RFEEMASLoE),m,OVASRTIEESR,N,GTENROUSSE, VAGINA, URINARY BLADDER. Histopathology : pLeaveCIRNRFOLNIACTIPORONG,RESSSUIBVAECUTNSEP/HCRHORPOANTIHCY,, mimniinmiamla.l. esson2 KTeirlmliendalonSabcaryif:ic5e4 ~ mExipnoaslureTsGrsoiugpned: oIfUfDAYtrom necxopsy Gross Patholosy : No MaSSocvRreTonhs.,copKBiRIADcINNEA,YbSn,oSrPmLIaUNNlAGiLSt,yCOROHDEb,RsNeTrS,vTOeMdSAKCEHL,BTDAULODMEUNSUCML,E.JESJPULNEUEMN,, NOToRrEEai,,ns,SPAGALLNACANRRDEYSA,S,GLSACCNBIDCFSUI,N,CWANCEONLRDOVINEB.,ULRAPERICTTLUUYIMMT,PAHRMYENOSGDLEEAN,NTDE,RTIHCOULS,ib 455092 Continued on the next page -- eeer re -s ------t --------ee eete Company Sanitized. Does not contain TSCA CBI O 0-DayOnlGavage SY y inRasicocc Duronsers --~ Showing anIinmdailviddautaal afnoirmailndLiviisdtuianlg animals sDooserGr(owiX c12o5 nna/ka/day Sex: Females Aina Rot Wicroseopie & Macroscopic Findings Gsson Continued rom previous page Gross Pathology No Ma"FTcHHrAioRRsI0cNDGo,/pLiGAcLRATNANDm,Ko,mPmEAaRYlAEiTStI)yVRWOoIEbTDsHeGrLOvAPeNTdDISC:,NETRRVAEC,HEAS,KINE,SOPdEoAAGURSY, CSAN/D (RFEURJLoEt),i,OVASRTIEERSN,OW,UTEORSUES, VAGINA, URINARY BLADDER. Histopathology: LeavenlINPLINOTION, SURACUTE/CHRGNIC, minimal. EacRETTRNNSPLLAAMGAATTIIOONN,, STRMCUTE/CHRONIC, SUBACUTE/CHRONIC, mininal. minimal. ~ TORNYorGsArzDsav(rP.EALE) No MiCoOcvRroDos,s,coSpHTEiOAUcRATGA,Hb,noSrDKUmEOaLDlEEiTNtATyLI,OMIbSJsCEeLTrEUv,NeTdMS,P:LETELN,E,ACRCTEAC,I,SRACIONL,ON,SPINAL EERETpCUrhTiTNA,NROYDMEE,GSLEATNNHTDYE,MRUISTC,HYLARIDORRPEDNGANOLLDAENG,DL,ANSDAPSLR,INVNSAACRYIYRNOTGTILCSANDGNSEL,RAVNEDN,SA,VDIRULAR ESTVRARADC(DH8EE)RR,,WITPBHSROMPUOAMPA/TGKIUCNSE,NREPRSEVOEAI,RTY,SKLSNLT,AERRNOEUVNMA,,RIEBSO,VEUTNEARRUKSO,H, UNROISNEARY EE (Company Sanitized. Does not contTSaCAiCBnI C9O 0ODraR laGavyaY ge Sy5:in Rts vy Duponto478 --~ sty 4 20651,Shfeomwing anIinmdailvidduaatla AfnoirmailndLiviisdtuianyg animals Dose Group NX 125 ng/ka/day Sex: Females Animal Ret Microscopic & Macroscopic Findings 655095 TKeirlmliendalonsDaacyrif: ic54e AEnxipmoaslureisGrsoigunped: o3f0f0AYfrom necropsy Gross Pathology No MAIaLLOIcERVrOTEoMARs,,,coBKPpARIiNADcCINRNEAE,YbASnS,So,PrILmCNUaENAlCGLiUStM,Cy,ORHODCEb,OAsLReOTSrN,Pv,OeMSdARKCEE:HCL,TEUTMDA,ULOMDMEEUNSSUECMLN.ET,EToSsetiosn,. ATNDHODRYEER,NOAILDSAGGLLLIAAVNNADDR,SY, `GPSLAACRNIADMTSTH,IYCRMONAIEDNRDVGIELB,AUNLDPASIR,TULTIYRTMAAPCRHHYENAGO,LDAEN,EDS,OTNPGyHerAoGLsUe.S,mp GPPELHMAAUNRRYD/NRK(/iFLEEASMRAYLJNEO)KT,I,T,OEVYABSR(TISEE)SR,NWI,UTTHENROOUSPSET,ICVANGEIRNVAE,, USRKIINNARMY BALARDDER, Histopathology : PN LiverFATTY xIowEYs CHANGE, MEDIAN CLEFT, minimal. CHRONIC PROGRESSIVE NEPHROPATHY, minimal. No MCCiLOOUcRLNrDOGo,NSs,,cSoTRpHOEiECMAcTARUCTAM.Hb,,noSDMrKUEmEOSaLDElEENiTNTtAUEyLMR,IMOCUbSJsCBLeLJYrEUMv,NPeGHdHS,NP:OLDETEEL,NE,VHS,AAOLRIPTVAAN,SREBRRSA.IN,CoSPoINAL NMEARNVDEI,SULPAIRTUILTYAMRPYH NGOLDAEN,D, TTHHYNYURSO,IDADGLRAENNDA,L GPLRARNADTASAR.YYROGSSeADiNnGmGLa.adrDS, 655095 Continued on the next page .... -- - Company Sanitzed. Doss no contain TSCA CBI -- Dbyol-- CwgtudyinkoDewosesss ~~ sor cenShowing aInntdeisvidduaacle nfoirnaI)ndiLviisstuianlg animals rice. i ieA ferme Wiaroropie & Facronsopte Finding sons Ccineed tron previous pede Histopatholony : Ho HGiErmsUaRrAoni(soEi)cse,,petemTBsoARTOmuGobFrO:SmSaU,lRNiTPEsRAAyRRRYGIbBSaLeKAArIBvNSeEdR,W,M SPAERMY GLeASD s(PEoUNLE) ee oa wham rach essus7 Terminal osaacrti'fiinceae pn Tra Se sumed of Eeom necropsy [PR _ No MHavocnnrmoa,s,copSFiIaconNtAY:bSn,osreTmiOanNlsGiSt,CyoHGnEb,AsReTBr,vreoSduKnE:L:ETBALiMUoSCnLE, Ssapvea, TRFTveErRmEOi,pRtSaTcCarhhMaoopnuRgA,aS,,PiSCecAIoRauiR,CdRCiAOOLvONRRg, AiPRSreERrUTmRo.AinGWcEESBaoPngESieA!toLESiAGMoUS,e r Cr om Pi ALSE Y Di VRADIS, OPvEoRu. AG, SREY maneen, Histopatholosy : 655097 Continuwo ognC'Eshe1 mete pase ---- r-- r -------- iea-- sesi --r-- r-- e CompanySantas Does ntcontTSaCAiGBnH C 2o 0aO Oy n Gvio M g iyn M nBaisG ) TicgSuyinRpaDwupos mssiry ~ Showing anIinmdailvidduaatla afnoirmailndLiviisdtuianlg sninals DsotsoerGr(ogulpINlXe1a25s9nfo1ej/nkg/dey Sex: semales Rained Rot Wicroscopi & Macroscopic Findings sss097 Com imued from previous pave Histopathaloy : No MS"iIcIVrNEoRRs,,coCLpOOeNGRSA,mSoHTrEOmAMaRCTiH,i,tySDKOOEbLOsSDeTEArNLvNe,WdUKJCSLIEU,HUMS,PLETELN.E,AORFTAAN,CREBARSA,IN, SGCCEoICsN,I,CCNWoEAtRoDV,EE,SRUPEAICRRTOLT,IMARNIEYSEGRNOLTDAEENR,DE,CT,MHALOIERSOH:LDNOGDRLADENDL:SALGLIAVNADRSY, GEPUVAA2RR(A5IT)EHSY.WROEUIATDEROGGLPSAT,NIDCSU,RNEIRNTVARERA,YCHBSELKAAID:DBESRVO,APMIFMEAGMRSUY,R,GLPNAINENDS.RIJK(/oFLmUA,RRYLI)E, STERN, SONE HARSH, NOSE sssa00 EKTxeiprolmmeuizneonGsrbaoecuyrpif i: c1Re83ECOV nny Le ined o8 feom necropsy ~ Gross Pathology : No NHaIcVorExoRs,,copSKtIADeANREA:YmSo,SrHmLIaONiNNGiSc:CyoROnbE,sNeErS,vTeOSdMKME:GLHETDALUMDUSEC,LE,SSEELTBYA, NNIOLODEER,,ESAEGLRLICAVRNAEDRASYS,,GLSACCNRIDCNSOTM,I,CWANCEMORDLVIOEB,,ULRRARIETCLUNII,NRGYWENGOSLDEAEVN,IDE:RTZACDSL,up GFTEHiAYaRRnOID(FLGELAAANLRD),,, FCDAVYRAEAR(TE8AE)VSR,WOILUTDTHEGRLOUAPSNT,DISC,VANGETERRWVAAEC,,KERUS,KRIINNB:ASROYNPHABAALGARSDY,DER, 655100 Continued on'SthEeRHeGstEPaJgeo.t,+.STERN, NOS -- Company Sanita. Dossnot contTSaCAiC8n1 CyOrO s GavaSuR gidevinRactsY Tosciy Dupons9478 ~ Showing anIinmdailvidduaatla AfnorimailndLiviisdtuianlg animals DsooseoGr(ol2T4X 61250Rfo1ekng/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings prey Continued from previous page uistopatholoay: xaoneyCsHRONIC PROGRESSIVE NEPHROPATHY, mild. Yo MiLcoronscopic Abnormality Observed : essa rEKoxirplmolisenudarleonGsrDaoacuyrpi.f: i: c54eS0DAY inal io signed off from necropsy Gross pathology --~ No MaIHOcVRrEToRAs,,copBKiRIAcDINNEA,YbSn,oSrPmLIOaNNlAGiLSt,CyORHODEb,AsReTSr,TvOeMSdAKCE:HL,ETDAULODMEUNSUCML,E, JSEPCLUENEUN,, ANIDOLDRESE,N,ALSAPLGALINACVNRADERSAY.S,GLSACCNEICDNUSTM,I,CMANCEONRLDVOIENB,.ULAPRREICTTLUUIYMTM,A?RMYENOSGDLEEAN,NTDE.RTIHYCMULSY,XPH GPTLRHAYANRRDOYTIDO(NFG/ELLVAAANRLDYE,,), BOYAVREAAR(TISIE)RS,OWIIDTUHTEGRLOUAPSNT,DISC,VANGTEIRRNVAAEC,,HEAUS,KRIINNE,ASORPYYHAAMBGLMUAASDR,DYER, FEMUR/KNEE JOTVT, STERN, NOSE sstopatholoay: LrveriPERPLASTA, BILE DUCT, minimal. 655103 Continued on the next Page -.-- --~ CompanySanitzed. Doosnot containTSCA C1 C DayOraY lGavage u1inyRacs Toy Dupon9478 -- se (csvShowing anInidai)vidduaatla AfnoirmailndLiviisdtuisnyg animals Dose Grow 1 125 mo/ka/day Sex: Females Animal Ret Microscopic & Nacroseapic Findings Gio [p------ Histopathology : ExAeRoAwTeCIvHNsRROOINDICGLPARNODGSRES SIVE NEPHROPATHY, minimal. MBASYRoorrGLepARaNzsDssaa(rF..EMALE) No MCiLOUcRNrDGo,Ss,co"SpHTiEOcRMARCA,Hb,noSDrKUEmCLaDElETiNAtULyY,MOUbSSsCEeLrTEvU,eNdNS,P:LETELN,E,AOSPTAAN,CREBARSA,IN,SoSoPtI,NAL PNNCASHONRALDVROIEYNS,,NUKL/PRALIREAT.RCUYILTITY,EAM,RPYHMEEGNYSLOEEADN(NE5TD,)E,RWITITCHTRUHLSOYO,PDETIACGDKLROANDENEENDR:A:VLES,SGALALASCINKHADIGNSRA,,Y, OSeuSEnonLacoeneinssn.GuS, Ps AUTRERROUNS,, NUORSIENARY BLADDER. FEMOR/KNER SOT. SHER Sov ess10a KTeirlmliendalonSbaacyrif+ic1e75 AEnxipeoaslureisGrsoiugpned+ oSfAfTELfrom necropsy Gross Pacholony No MAaLOIcRVrTEoARs,,copBKiIRcDANTGA,YbSn,oSrPLmIOaNNAlGLiSt,CyORWODEb,AsNeT`r)SvTeOSdMKACE:HL,ETDALUOMDUESNCIL,E,ToSseoLneemny,, 635104 Continued ANIODLDREEE,N,ALSAPGLALINAVCNRADERSAY,S,GLSACCNIEDCASOT,MI,CVANCNEODRLIVOBENU,,LAPRRIE.TCTULUIYMTM,APRHYNENGOSLDESAN,NFDE,TRGvSsL:oup on' the next page... --_ -- Company Saniizsa. Doss notcontainTSCA Cal (PSDayOrsGavag Study inRasic oii Dupont9478 ~ Individual Aninal Listing Showing animal data for individual animals DsoosneyGrA oup: :% 1c2o5smcge/nkg/day Sex: Females Aninal Ref Microscopic & Macroscopic Findings 655104 Continued from previous page Gross pathology : No Ma`TcHrYoROsIcDo.piGcLANADb,norPmAaRlAiTtHyYROObIsDeGrLvAeNdDS:, TRACHEA, BSOPHAGUS, 'CPLHAADRYN(/FLEAMARLYEN),, EOYVEA(RSI)ES,WITUHTEROUPST,ICVANGEIRNVAE,, SUKRIINN,ARYMAMBLMAADRDYER, PEMNUR/KEE JOINT, STERNUM, NOSE 655106 Tkeirlmliendalon SDaacyrif: ic1e75 AEnxipmoaslureisGrsoiugnped: oSfAfTELfrom necropsy Gross pathology : No MaLIcVrEoRs,copKiIcDNAEYbSn,ormLUaNlGiSt,y OHEbAsReTr,vedSKE: LETAL MUSCLE, SPLEEN, --_ ALOEROTNA,, ABRNACIRNE,ASS,PTCNEACLUMC,ORDC,OLOSNT,OMARCEHC,TUMD,UOYDEESNEMN,TERJIBCIULNYNM,PH NATODHDRYEER,NOAILD`SAGGLLLIAAVNNADDR,SY, GPLSAACRNINDATSTH,IYCROMNZAEDNRDVGIELB,AUNLDAPSRI,TLUYTIRMTAPACHRHYENAGO,DLEA,NEDS,OTPHHYAMGUSU,S, GPLHAANRYDNK(/FLEAMRAYLNEK),, OSVYAER(ISE)S,WIUTTHEROUPST,ICVANGEDRNVAE,, USRKIINN,ARMYABMLMAADRDYER, FEMUR KNEE JOINT, STERNOM, NOSE --~ To: `CompanySaniized. DoesnotcontTSaCAiCBnI CX 5O0.DMsyDOraluGavagOeSyninci Racs Gicuy ageSodyinRDpuwpe eonwco9sn47s8 ~ APPENDIX O INDIVIDUAL ANIMAL MICROSCOPIC OBSERVATIONS LISTING INDIVIDUAL ANIMALS AFFECTED ~ -- Company Sanitized. Doos not contain TSCA Cal ~3 2 3 TI 7;G3a%Gigiadashciiiniid | BETTY Bam 1Fo%l]gla[iEEET GCEseses giesasais [EELEEEE LE Bodden 23 EEG By ABD fER GF SEEMS id, Slay if I 5 HE j= nn kA EH idz i 1 }i ! | iiIiHg:] :Lo i; ii 1 : i ii &sl |: z ii i iH EE: Eo i ii ii!: 4 | 1 i: i ii gSi i PoE LEf gd f " iihsd 3i CompanySaiz. Doss not contTSaCAiCno1 ~i z jah oe iEiT os bFE'Tss i TTT io2000 ~~ 2g | i i #0 Ii :] g| 81 C[o--d Eii18s = iif itr do 3 } 23 |i 0 i ii E 3 5 jag 2 iidfa | iE Fo Company Saiz. Dos etcnnTn 1  g3 PITTRT EiE ogi ii SEE NET TE pie fH gh g3 isl IRE | 2 35 i le PEEr ~ lH i . ig 04 1 iF Hi ify giHB | i15is i iEi |:| aiEH fi PIE if ` 1d Z3| :| PEEd E BiI]k 2 [ET A SL SBl 8 [EEF EgE Eiiik CompanySates. DossnotcontainTSCA Ca ~3 z5 1 TRE ERE| P oigi Emm |S n BEIREERESE | i ig) (IaET i Bo g3 igi i.RB ig g"f Y4E m Te FmTme TaEe pEneae aE 1u9d $f jij7e SBESEl SSSEEe Iq} . ~ Eo hi # ii iz1 LEN in i i 5 i !| iiZis sf zd i} i3is Id i5 ii iFFE |Ld: ifry aoo bo pbi: 2HSI Tg 3 8 IB 3| LEE IZ g CompanySeca, Sowsotantan8GA05 ~ glick 3 olg{lTTT[E BR T| 5 :3sEeRgEsReE3sEsEa|g| PET iE fend i i oigt iT i $a 2 if (jo 7sssR sssasie s ing A "Ea hi k eof ia iHi : ish Po | i a iq | ok iHr | PE i iE ET0 ii iis Si i5d ig: = Company Sats. sos econ750A 01 ~ 3 Ti 7; zsssgggEzz | ~ ET k ; jb dE iBH ,aiHrEd LE i 3 gi FT gEmaEEnEr at Boo 4 Fo i is fl ii i| | h4ed iH Li EE P Ld o iiH i=z ;Eo : iH i oga oF rised itHH 9& Feem at im eeevemse mmeme } BS =| nmin, bm ~ 1 oigT i ERs T1L T 3 E GEEE 3E EISEE EE | gE gba 5 BELL dt is 3a) fore 3, 5 i ~ | EH 500 eR. i | 2 333T 3833388 sf 3. i ii i588 ? si Fd iz: ii Fo ;i iH iis i : iii 8REi |i 1i55;2 Ho :i Hi & if i: f yoi r fd iif of iiff ih &2 CompanySass. DoetsamsanTSCA01 ~ 5:i B 3PpogRaEll yEim| e iig fHf gr LE om3 ~ #E05a IbEi] : iFi ;| Hi Hs NEi ij [ii5: i odod i: H | PF iE. if: 3] i i332 Eh Y ~ 35 1Tswn HP I HP e IRlEie is Boal 3 -- B$$Ff oiiT ihjeRe ii EREBEIENE1iig4Te 5:. go ig Hi IgE H[aE |i iIiHs i ! ii & ii 3| i| iHEE] 2 Poe iE i HEML ii; fo S l l ii fi EHE gs e i iiiEssk Company -------- Santas, Dos otcota TSCAGBI ~i z5 3 OTETEE olgl Emi C E3EEE3Y O 30gny d i a] aT, i Fg oil BoE Tog i a : "laos ih go1 it :i ii 4i HI i iH no od hl IE.EEPE iiE <e qo ioi F EsE e E iiEtd Company Sots, Dosecontin 50HCB ~ POTLE Tgmn j2 oolgbl E [eFeRx ii E 33ESNRE3N|E| Pog : p ioriae E ih 2 {8 TF iTgagassacas if ~ E50 1 feR. | l 3g amimy % Ep 3R3EE333333i3Py282} $:. sf 204 ig i i| | IH do if i i ii gl i1 i ji 55g ii }: if | Cd i dg i | iE iE # [I i IH e o S fi f e dPaEcRe is 3% =| Company Src. Donsecon TSGAGEI ~i 3 TET; sees | igi AMC sasededed jodie 5g BLLumis B0o8E T a IE3ie i ike 7 SRERERNEEE I h Sof EE i i % oa # Hi i BIEo ii i of || HjHf SE !i 1 HE | i EM iJ |i LlaE iiE: I 2 i: i 8 } ae iH CompanySaitesd. oes ro contSOaAiCBnI "i3 Ho ii El: Lo 0 jE Pogi em F iL oo gp HEE i HE ii2 L 8 3a 0 TeFT; ggseEEanas iiuh E80 fel i 2 SESES8485% ivf . TolEiDi Eo E ji 3: ito FH B 1 i; iig F: iis 7 FE i ii | iH3H3 IH A ; I y5l5 i iii i higE: sl i 8golif fe 5 io 5i PEE i g ~ 2 fini To inh 3% isi iad 3 3333 333332 i3 HS IB} mem e------ __-- __-- vweo2 eew% __8 ___% _i%%g Bg i3l 2 $53558BE2onNIeRANAE 15g To EB og # gi0 0Fd ii f | i| i : :i i i| ]: | ii 2 d Wo d 1 y | oi , j i3 :g s Ci 1g Ii:E age gi 5] ; is ih * iiiga2 iHgY i32 i(3v%y hii5Bs Hisik ig: CompanySten, Doesrotseman 50 31 ~23 1 T GEL Tgfgsggnpasminie | GL -- q jE] GREE GS Bsesfsg0eSr gual Bopp ewig 2 iE BT IE ~ d fpqigE el FHi . & i|| i i ; IH 83 | i i gl E1gRi iPi o, y ii h rC : dh:k Pog1 iEgk alk ihIH 4 ids Bi o, 0iv%y BLoiln Hk Ais ~E :Ysommi m mesea8i stmeeibm tsm eraatbesec ise} 9e [ET ---- ~ 3 yw BE cd i 3 IT PEoii EER71;2 jEaRs3sEcIiIaEsEEE:E || Paes gli Ey8(ED TioyER iTTToEEEREIaNEgjiEsg EEBoRE aA iii ? i iH Po {5 i HI LPo f 3hi 3 1 f irii iitt | 1 iF is i 5i [LA iz ~ 5: YT mE SED 1h 2 Hid i iid TTT F3o 0 ljedRoew | FE2 E33S33333338 441 . q Bodo 3iB I iit i i 3| giHiihs zg i gid 432] ii . yo Poi g oE z d gE giE:y E1i5d Company Sanitized. Do note contsain TSCA CBI ~ :: job a 5 HE i 3 HEHE 3 TFT i# "laERI 5ih J B Loi E5H HiHEi |i| iiifHf Jd o IFHF fLo ro: ixy i go i J o E 1 iR EI E liik]H Compson. sontcrn ~ 2 pe iy ; ogy #i0a8 ri iE ai Bol | Fg ESe R r ~ lay ih . #Hg 00 ii HHEi i iHsk i 3 i ;i iifi gl : iH] oy hi | JHIoEi i B Fe Pig i Eo1 E[Fig iiHi HE {32 ee eee _TEE 2 CompanySantis. boss econTsoR Co -| TTT. HI 103 Ha 7 ToISEpa:EiEE E) a REEF REEEEIEG ; ~ ila o y=ifooo iL i i 3d i no Ii i i: Hy I y id IEE BE 8i i808 5 ee hiy FE iiighs ii: ; 152 AgBii: giE 0 Fed EE GompeSitit, ostemisGaE ~ 5ii OUTT T TsaL na E | jgi ifEdedsd| PEE EPpaTI ICICLE ig H gy ErE i Spidey Fh : ~ lah i g i i ig Pi i LF fAlN: ; sf Ci fi ih gq2 i i0 Ay a:Hr | iE i5fs oF iE Ld H Stereo IIS ~ ES 3 oigT h L EmsEi ;2 ZBaEmRaEEgRaEnRaSEE | ozidg]! E eiT|T i "Er bh $f Il oR.fCgSagsddaylf : : i do i iiH 8i i| hi383 71: 1 ;i : iiii da fo 2 ! ig i f i5: && Pi oofsg iiEd iisds CompanySatin. oerot oma 5c co ~1 2 I {T T.F To EEEEEEIEsn PP osen n iopiisP iE e}iy H 15 isl fT m Iman 2 3 eRe fC SSBBIE[EgEf ~olED HH . 3 E #00 Fi ii23 Gflo ii af i Le 18% if iE 1] { [IE i ii: gEb T HHiH A i833 iE Company Sens. sos ekcnnoc ~ P igi (ERs n 2 EEIEEISESE d5 uBEA is ii8a T i omI ~ uly 5 31% | |ig ii ii5zfe io NE E Fl E i5Fg i sy # [I = ; ii: i i iif: i E1H5 5 ig ifag lr 5 I. i CompanySnes. Dons etcominTSCAG1 ~ 1 TRE ZR oid eTmFT| Pay HitEHIE eb ERR TREE RRR 3 Hig hi] = Ho if Boa if HoT iH i ; i i: 7 Pf iE 5 i i3 = iH !iE i2 fix i12y2 i | i HE ii4H delbo L f idS e E iiEH = CompanySanti. bcs etcain150A co ~ 3 3 T T.E 7 ToZgsmroaEzil pie PPooEem TT : i HHH rT TT iola T ai mE i PR EE LN . Hoo iH: 8 qh FH fiFoo i Ii : : if ii i i5d HE i iq (Ey 5 25 i H 2 F ; i| 1 ig idi iH 5ig: i i 2 Pee LIFE =| (Company Sanitized. Does not contain TSCA CBI | ~ 5 I T 1. 1 ToFEEEmEnz i ioe | Hoi HO mm ~ sy #00 iH HL # sJf |i ii4g3g2 i i ;i Hi 3 SFi i; iif HL2o Eg E ii g8 d iisd42 EE2 |i iPgdfss iied 2|, 3 i| a zg gsigs FC i i A ee eee e iT CompanySas. bos etsama Tomco ~ : PITRE Tr ann Poilgi (ER 3 EREEiEagE | iodEjgEIiRi[syREi| T 3p (Bin | ii3s gi Er HELL iz RN 58 TTT IEEE i J J RA CLETE LE 161 HEE 1 A #H0i0g0 iif ' HE i Bi i ii 4i | ii2 i a ks Hgl E1 EPoE iiH 0! H2o i [fo iEo IE Hisl y dg r g1 if iif gC fait i if is CompanySatis. Sanctasont or isl LE YTogi EmeT l T8 EORmEaEEnNEE i2 E0 jI am | | H iPoiglyip E y o E | i mi ! }3 BISoiygi | mmm 15, i jejzt ~ ED io TEES 8 H iH A : Bgigiii i J | 31 it14% i i ii Zs ii |i iHH f1i11 ;i ' HiHi id 5 ie 1 i IEE He] 5 isi142 i0 PY fo L opE e E id iE & CompanySatz. Doesnt conti TSCA Go ~ i:i YO E Ti E OED ITE {TT 2 oT ToT IEmmn TTTTTizssazeziz rman, i H 8 i-ioRn jC SESSSSSEdaSeMdREydf . Slay Hs F Hq} i 3 if ] ii |i i iils zd i ii Fil0i40 i| iHxs 3i | ! IE 15 ] ! [I i yl 1 i i iE 5 Ci oEg iiErosg ig iisk ComerSets, Genetso TSR8 ~ i 1H 3 EEo RPYLIaE CkN. o i : PTT f Gp iEi en i n2 eig gi By (EBD T i-BR i = d3 ~ ge Hop jt 4 = f foigi iig i i Bo !| iifsH Fa i ii i gl i i gi 3 Hiitp IE LE og i tI PE oa HH Sd i;o Eii g Eoc IiHts] Sf PEE i A Company Santis. boss ecoTsoAnGn ~ 1z PiT gi {LFEe Ti romEEaaEEiaEs Pn TT | i i LE i gAi EH oiRp gigi iyj-- f --!it a 4, iE90E0 ePB ~ | FE __ 583323338 [9 i 2 fE i g fF 5 | i1i3 i iBo ! oF i iHH hs id FLHEI !! p; i i 1H ii 3i soroF PE i iigs:} iB iiifs | ELE iE S| CompanySatis. es otoTsoc ~i ple Pog ime CFaERERRH glHidTe i Hy Clay #00 H i ' Ho Hh i: LH yi I Wd I Ho Po if F i PF f iiEz d8e% iIdH d LE iE -] 3 ad Bat -- FiP Tg EESigi}iz Boe i I a NLL+ L LEM | " og i045 | ih IE 3 i Bi HiH i 2} | aii 7 Pod i So i IEE 5 ff hs : i PE i ik 2] Compan Sans. sos etc Ton co ~ : 5 8 TOTES folie HH l og Aa!iit #8 TT ms 3p jee iC gdseadedgiif : ~ a 22: 0| 05i| i i 1jHi2N 2? 5iH3i0 i i iiig gl Pod iat i 8 i Loi i[ Hs ; Ef EPaE]L Eg iifi: in fl if ih =| (Company Sanitized. Doesnot contain TSCA CBI ~ z: I1 oTigi LiEfmT) p m 3isgE eldes||d P Jog E oad T i 5ioigBiEsdLL i iig #0 13a) ieee IE if iiij Ce ESESER ESESe T[yf : "lug bi 2 BoE 5 2 iE if i i8 i 1 3 : it 4 i i352 Eli | g if 4 3 | Gl ;L | di EitNhH Hoi r o PEtd iiifss BF if Ee i ~5 irs: ih Company Sanitized. Does not contain TSCA C81 ~ : YOTT T LE| & igi %EE S 3388385888 | sh RE TT 3i g (gBiizE!iaI Es 1i TT, | ig d B, GED T iE EEE i5 Ho i ~ H 2f iod | 30 iiiHH '8 fF of i fi 1] {83 i i i i | i | 155 [Ed sl i i 5iss HER og h go i 5% is iq at i | C>/I E i Ei| iEiEi iiifis gs 2 Copano, cometo50 8 ~i |i } TET:Hanan 3 I aE i i 3p dE | ii oI8lrea r h THEr RESi3 . ~ a |i 5 3iH 8 i is | iiH Wh i SF8 . ia | i ig iui i se a Bg iE i HE ] iL | EN i S| i 8i 3 is 2 comin Bsmgngn ~ YT EE PE agarTL 3p (B1Fiebs | HL ETT IH #0 By {Bl r i-BE ah3 ~ | iER (0 f ydeefn )| 2B33E33E333R333.8 51 4 B# no o0 HPil ;| ii || i1i3f iff iiiaf . i Ho | io i] gy :i iH yf ri iilL &8 Compas Stns, Sorts ~i z 2 Ti TTT.E TC zE@aEREzz gz i joan a E Pir E Ei Hop EERE FEE ooI d mmm H n+ ~ |= HEELBf ) ih hi i 1 | iI ' i fom Pk iiid a |i dfHgiEoInL i1 i di HJ o | pCi ff2 EfFLoyEE bi g HhyE FR ------ diEk Compson cris --~ i z } TTT ERRFIRELLMN +1E 501 E 0 LA | pik 5 iA ITE g 3 iE Er E man iz i 3p iol fC gseEssnsgdf . ~| ii i g #0 $0 il ig ig EHgE| ii iEgH do 4 ii Li IFa. ii P|i y Ho io ig8 o1e3% HL woo, F nd 5 35 i iE; ii HE i fa JF | or FE-- LiEiiEiH; oi iEE iE 2 CompanSanti. boss econ TSAG1 ~ 3 OoiTgT EEmTi s% gERaERdRnRRcERaYse|: i g iE jen Ei P 3p (oBElE g| hiyi}i i EET TE EGER Ey _ aoa i iiojele i hi ge9S88F #88 J 4 i i+ ii 3 : ESlfF gd ii: iisE 15: gi g isdi]E a yf i iH isgy l fiPELE 5P IBiii: | il L Pf fiE fdf E [IiEiE]i S| CompanySaniizad. Doss ne contain TSCA Gol ~ 3 2 ie F 1PoT g (Ems iE n g2 aE3sET Em3E338E | iFoodoenk is g5ig edi Tolug hi if joiojeBa 7 SESESESEEE gf i BoE ii iSi iigls I [i ! iiH 4 = 0H,E HHlH 8 sf if i 5 & ii i if Ef is ii11h3 [CR S--------  BE 3 TTR; sEggEnIEE | : tH rT ofgogrER i a (BiEIaEs | ig 4$aB wm E f% E3 ~ B8oag ihi 2 fi p07i 1i Roi hE. g "TTs CS8SEgEEh iERESeRiMe iEEiEEREEEy R4 fisst . ii i| i[H 2 fd i iy 4 25 i 4 | Hsol 8 Pf Hi i EB ii i f id, eti: Company Saniize. Doss notcontin TSCA GBI - 3 VTE naan Pan igi iREm hak FEEEEEEEEES i jogo. PiPI IE gist 2 ; iit g Lokge i{2 #8 ~ | 3p iijeReiCEesedsidadsd grf n Hoh i # d1 o go | El1i! H4 o 3 do |; |: E- lil ilgebld i13] i1i]: iy 1} Hi P : is gPmBEEE El (E td B eeeeee IEE = Company Senta. Dos otansnTsoaR ~1 i2 ERLE nk isi Fre} 8ERE GRdSuRGdOSRMNEEN| Pode I 5f 2, Bdeiidty iT ioh4| BE Lhe | i, HE TOE SoHE I|| 51 i HiEl |i : i . 38 ? ig i iii 1 Wb po By 23] i ik 3 i 1& i ii: E {lk sf gs dE PE el iis iE 2 CompanySac. ossetcota T30A 01 ~%: ITTTLY Ta EE ls isi Bh.8 EE G fog lee Bie m3 Hiri id TEig iijeTy BEiTG kgf il a HiEo LEiol Sy pk i Cio oo Zig oe l lF f gk E 5] 3 .: mvs ram ~ 3 TTI YF 1 - 58853s@sgeEniaise EE Toa m sEE |G Ba EERMd a m G48 e| 2 lgigicy i T,gzssss: 2x i 3 sy iBD iI oBw E | 2 E GEAEE EAE BaE 1i3; qi h 1 [LoPE 7 SSESERNSUNENN0008 0 gf ~ | Ei I i . ik . 8 Bo 71 Hi i i i232 of i ili EE : [oe i iii i id [IPd : i Hi 1] | if PoE 0, g i 4 15g ' ii: i: Compan Sate. oss econ TSA _f f 3 TTY Temas Bob LFIINREE IROE PL a pL a 3h , Bfteiy g Higi ii m 2Fdi Hi Se : ~ HE 5 3 i Jii fi 5 2 i2s i ooi r i jgt CiP HL Eiad :Piid iis PfF aEEl a i | E gi: : ri ~i zE 3 TU7T -GT gEna. gsss s | Pim | IPog E) end | i BL bY gb or mmm 2 "E HaI oy ih iin fo i ii i iiyi AE | it i f2 i i i 1Pi558 sH l d [I iihE B PoE yh s ii CompaSattnd. eset . EAE ~ 5if! IT ToEET EEEmaaY ss ' Hfyg IoiginE | B Hir gham ndi ~ iE j--EEEEE nEopy Fl BEEN iff i 5 t isf i]; g1E] i | i ro i gf i 3 sli Po h I A yyyo 1 C1F d fo Hf if S| i i igs 3 is 2] Fee eeeeee HE =| CoreySet, ts5on ~3 4: 2 {TT T.F 7 - BEEEEimn al Poe G i L pyEri Ei Eig] ebm 13 if (LjoRE CCSUdEEIEEEE yf ~| i 1 J ie f HByoa goo IiHh i i gi i| i Pin i fli] C| e FHli 4 if Ls 3 EEEi i iiiyi o | f i ig FLYi!&| CompanySanetsond ia T5. 0AG1 an | i= En | dnddiiid|e Poh Bgl odie Ia fe i, ETE i2 2 8 Ty iTCEEEEEEEEIEE isd -- 53200[ 0 ioe pm | e 2 FE5e RERR3REE F i 2005 Blog [if i ' ii if | id!| ii1] gl : HH <I I. Podi iihH Le Tl Bl eee iZ& g SonounySens, Gee etmeTSH z ~~ 8] P ozmi E {Eh i 8 GeE BEREEEEE | 5i fEfo i-fkaggy!ii iH f E nyli ~ |35g 8 jr ee|GEi REERIEREEEm EEY 57 4 gB0i0oa0 ii HH : iHi || iiz sfi3 i | l5ieE;% HER go op Cd gs Hi SIyd Pg ii: d qo Eiff iisf & Sort rama ~ 3 3 %T Tos@Esagsiss i ple.0 2 fgidiTy iT HHorOii mma 3 3m EHR SED He # H 0i0] i5 i i iE i` i HH Po | i i i i | Dd i3: ao 1. Lo il i rd i Is Comoran 0 ~ 4: $P l B T TyR aL a B n PFoo delge| Hip iHE | it di i iHfHpoHTLiinlIowE Eof rBgamEsiaanag 1H : ~ Eh i 5 goo0 3 igii ; iigfs I ii E2H3 gf ; i o2H i Di d riia] = [I iE di i i2 ish St, SovnESOREY ~1 3 % ITT ToT SEET TEEL IEEY i pliPHoidea in foggy i Bgl E ih IIH 5 Ti Imma us ~ | i jt fmssaieRia i : a0 i 5 Boog i 1iHi a 51 i 3 i Dd Hi FH | [I EL ; iit 5 Hor I iH [5J iF 1E 3DaR |isd : CompanySaitzed. Doesnt cotsinTSCA Gal ~ of } TFT. SoREEEEEIT i it :Jf oiggoenrdl El ie,| gSH olmf it H BE ll r Le r| immed3 | B fF - elmjLEo CssE I tessnE R ieeg IE 5 n} Boy i g Bog EH HHEE ; HiHh i : i I i i g1 01 | ii gSl li C| E iiii 2 i PoE FE [. i[ & ii i #& f[oE f Eid (id4s i CompanySnlgad, Does ot contiSA GBI VoOsLm TEEEEEIEEEEED| PET ; gP1y0o0iHEgpiizsimRsgi- 1i HH alewm i i2 ~ EifTj-4-1220 ERE 1i : Bayi oId 4in i i bioi :i ij iH 4i lo EE |sqfa | | Pd i 2 PE iiil H ied iE CompanSans,bos etcTSAG1 ~i g2 FT FP 1Aoio IE lRauggi igiyodi H is keiii3, $5%14| )1 HE iFoBTmI| s2mZEzmagEigedmaseadER10%uEe :. ~~ |i I ; ih : Ll 0oidI 1Ii3zH;: i | Hi Bo i Zs gl ; 5 Ho Lod HY) J PoE i E i ER i iHgi: g Pood ie led | fR A iE lS = CompanySaritzad. Dosne contain CAGE! ~ 23 I ITT yamE Poli 3LETHp hja EaeeR | Hi H 3HEiEa) fee 8ii Ho yi mmmanl Boor 1 SE gf iii i{2% g& io o iiBg iiE | |; iis iii ;i ; i1B Eglif |a I Ele 1 ; IH yd ix Hg PoEi Ee : iEdEd 3 CompanySanitized. Doesnot contain TSCA CBI ;i % ITT ToT SsT EsmI simE s p Pop Elen r iee s ~ sy i 3 2% 18) " iT EgzsEeeaaa | 33 23 2 [00joloigsn | E2ESBZEgB3BUaSazUaEdSa Sigifd 2 Bo il ii | iit :i : i; fzfll le i Lii og Ii3%Hds EE 23 ;i Ii 8 iniiffs: ~ 3 2 TT7 T o 5T EEEo zEsE sE i P FPEE od o E a T p}| Hi EHEE i Hoge i ~ Ey in : FE i i i233 i ; iH eo | i Hio | 24 PHo3EL i P[|I l ffiia: +. i FH g 3Ho | o igs tHii 3 2 Copy Stas, bi Toc ~ 3 TTO S SEEgF EEEEE | Pym oiP li E o pads p | pi| 3#B3o0AETCETmmm ii3 8000 om iF GaRdREsaee gi ) ~~ Boy iE ef TTITTTTITTTiER 2 iB$0o| g | iii!H i | is i | igi | s5 o || 3Hs TIREE PLoyd ii 1H a rn 8 r } d I. iik s PF gs iH lS Er EH =| Company Sanitized. Doesnot contain TSCA CBI ~k 2 % TTT 7 -SsEszeazez | f: oiE e I ieR PEH olIgigRi-gRim}Hi got 2 ES igi iE i 8} 8 rind 3 LL oFR1SEESNONEEinEg . Sol fEDio ih 51 E HiOE] i] HH ii : i 3| i {ig ii eHli op H fp ih ai 3 if i i 4 1 if Company Sanitized. Does not contain TSCA CBI ~ 3 {T7T ,GT A8gE. esiEF g | Pm P h ERNE HELo i E y la e Hgore omai, i ih To Es i ii; ig sg ig i : if i! : EB : : i gi! ; i 4 Pk HY oi I. it PFoEis og 3i iE ih ~~: 8 CompanySanitized. Doesnot contain TSCA CBI ~ 23 1 TET Ean "lE oy k ? P LI HLTI i . FIR H HEERT R 3 Hiri $T 3 i i | {oBnS| sBeEsRdEnEeEsIdEEESeEd [40g3 M Big! ig go He if | 18k fi ! IE] $l : EH We iH Zl d2|o 4 Ld | if Pik ii 15: iPoyi P53 F 1k iiifdhys Lovina msmmmmmeresereeeerseressess | BS CompanySantis. bossecoTSORnCo ~ :2 Y IT 7.5T 8%083aF Ees | I 1Pio E) p isEEi iTziy id i EE ih E Bis le y i 8 Fi TIE a aE Bo 1 ~ lay ih : 8 Ii i a i | : iin io oi i i (1 iz E [g HI ea. 2i i sl 1 igs of PE 53 &5iH HY i iE [Or ---- iH PHo iet lyi L8 n8 rim hr i CERRARESLL : ~ SHiT00 ii; io Hil 3 ii Bob Pl i in HilElN i iiH 5yi (14 iLiH 5 PoE i 2 lr fi iE < Compan Sin. etcorACn ~ z i | iH PET iifogHjz;ejsskE | ed Bi| BES i2 Boia ibm iE 33308l0) eTewn Ts Tsi;BegSEgmsaEnEeadEnEiTigEaiHgfn .: ~ ED i 5 fEloog 1i5i3 ERE BE 3% | | ig i | ARR iH i HER : i 2; I. ia 2%] | iE ii: =: rE iH gf 1ig iiL H | iE ik S| CompanySanitzsd,DossrtcatTaSCAiGn81 ~ TITT g mL amE e SE I 1d at i Fio gggy Hi HBoRlCe ln i{ HEHE EE EEEE EEE 3p (i jo | S8BOSINIEN1S3E) A geo ig gi iE i | 145 Pil ii FiE 2| 8 i If i | i{i3ig imi o x iHi S oF F Ee 1 FO 5. A 2 i5d1 --| CompanySane. Dos otsatTSaCACnt ~5 :2 iT1T g sT agEE. iEaE E | pple1 [sIoRiElIRLiLEEE TT | foi Boel aE i, HE Ct hi 33 |L-io% | C EEgEEcReReysf n SED i 2 Boa if gFiio :| iiiHg ii i iz 3| i gf [ifz 4 gl LPo og iia; 22] | Pd H Po, 1d ge ifs BF i iH i i Pg 2 ied B Ed = Gompany Sante. DossnotcontaTiSCnA CBI ~i $ TT7T - 58. 5888F 385 | E iE aE m| 3o , gfilleesg e | iiH iH iz grr SLEiDno Chgi 3 sf i Eo iH Wb sf: ii E5H ili i if 2= i i] i} i iiidf ii: El 1 fe i 3a =| Company Sanitized. Does not contain TSCA CBI - IT LY TggeEmeaaEad | sio 003 TiEam TT i| 53 hogi i id T, IF f $i hk i 5 F314 TET; EhEEEEREEER an 3 jE 2 - oa i | (3% ? i rnooio iiIf i ii Fa i 132 1 i i HE oe i i | Ld 4g E 5 - i [I iE PoE i: ied | BE iE ~E CompanySanized. 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Dos notcontSaGAiGBnI 3 ITF 7,saEaenagafd | if)o aE dslii ei , i# Hae 2i #1ial T Le immi 32000 loEm | % BE3538888EE gf . ict Shean ; Sola i : Ei 3 iHf |i iHfi vo | iH sf |i iHi LE jE i i 5 FE iE Lt H| PS i HM Fl3 F P i E g Ei d #ef 01i5d3, S| LER -] CompanySaniized,Dossno conTtSaCAiGBnI ~ z5 P 1 03) ian | mi 2 oiiriy oi glee Bs 3 4i00 1| -2lo2Em |2Z EZEEASREAERANRERAR I.H 5 SE Hy g Boa i wip vo | H HE' |3 3132 gf 3 Ha:o PPo og ith qo 1H sl i, IB] 5 i i# P22 comSot Gres TO ~ 32 pie orToman isi ER. | Co EEEIEEE Pode POE FE A i Iori Ly EBSOiNsi lrwrimmEmE13, BEE [HE iii : 550 id I: Hi ! it Ed i [HH gfii | iig uo Hg Gi 1 # Por ii | i BE iE 2 CompanySane. Dos toniTSCAG1 ~3 5: 1 TTR ET] [ HI RCEa pte 1 3p ] iiaEEz| ityit| H8ig mm i, ~ lay i : B31oa 5i HE it Sio | iin sli In o3 H | 2it I g N 1 is igfi 3 if ih Connors rst ~f gigs1Poi o[p3]a iaEbfRT| | gl hm 3 FH CF rpm I SE ks * gf (Ti EERE es #B1log i1i Ir a ISo ;: iHis gf i 5 ea o PLodt HiiH FEGl [I i iiE CI Eid | Pf igs iii $ iE ik [---- ~ 35 } IT 7, ST 5aggEF ages | sj il iE TTE gle 3g iijoFR | EEESEERHR|EEf n SEgH i5 k ii : iFEH Pl | .i sg| li1 Ci d Liiil 1 ITbIoy ib 5 iE lh (CompanySanitized. 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