Document aBajm5NJejmGY3E6BErQnJrXR
From
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J. TRAVIS SEAWELL
9/18/78
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Dear Dr. Harris:
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Attached is the University of Louisville transcripts which should have been sent with Mr. Seawell's letter of September 15/ 1978.
Inadvertently, the Technical Proposal for the 1979-80 research at the University of Louisville was sent with the September 15, 1978 letter.
Please return the Technical Proposal at your earliest convenience to:
Mr. J. T. Seawell Manufacturing Chemists Association 1825 Connecticut Avenue, N.W.
Deceived
SEP 20 1978
MEDICAL DEPARTMENT
UNIVERSITY OF LOUISVILLE CHEMICAL CARCINOGENESIS MULTI-DISCIPLINARY RESEARCH GROUP
I. OVERVIEW
Slide 1. The University of Louisville has a multi-disciplinary approach to the
study of chemical carcinogenesis, especially, chemical monomers. Vinyl Chloride was one of the first chemical monomers under study; we combined a cancer control program which designed and implemented a prospective medical surveillance system for identifying occupationally related chemical cancer (as shown on the left of the slide) with a clinical research group which worked closely with the medical surveillance program in developing better techniques for detection and prevention. Basic research in the molecular structure and pathogenesis of carcinogens, especially chemical monomers (as shown on the right) made the third link In our multi-disciplinary approach to the study of chemical carcinogenesis*
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Slide 1
MULTIDISCIPLINARY APPROACH TO CHEMICAL CARCINOGENESIS.
CANCER CONTROL PROGRAM
APPLIED CLINICAL INVESTIGATION
BASIC . RESEARCH
'YL CHLORIDE OSARCOMA
MEDICAL SURVEILLANCE SYSTEMS
DETECTION AND PREVENTION SYSTEMS
PATHOGENESIS OF
CARCINOGENS
MOLECULAR STRUCTURE VINYL CHLORIDE
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SLIDE 2. This simply outlines in more detail the various components of the cancer
control program which Include a screening program, a data bank, an epidemio logical study system, educational programs, counseling and rehabilitation programs, and the treatment program.
Slide 2
VINYL CHLORIDE ANGIOSARCOMA
CANCER CONTROL PROGRAM
APPLIED CLINICAL INVESTIGATION
MEDICAL SURVEILLANCE SYSTEMS
1. SCREENING PROGRAM 2. DATA BANK 3. EDUCATIONAL PROGRAMS
COUNSELING & REHABILITATION 5. TREATMENT PROGRAM > DETECTION AND PREVENTION SYSTEMS
BASIC RESEARCH
PATHOGENESIS OF THE CARCINOGEN (s)
MOLECULAR STRUCTURE VINYL CHLORIDE
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SLIDE 3,
This Illustrates the past clinical investigations done In the detection
and prevention systems. They cover a variety of areas such as #1, looking
at the appearance of normal human bile acids as a means of determining liver
function to the Identification of potential chemical carcinogens and their
metabolites by new bacterial systems covering the gamut from clinical to
basic research in the area of detection and prevention.
CANCER CONTROL PROGRAM
Slide 3
VINYL CHLORIDE ANGIOSARCOMA
MEDICAL SURVEILLANCE SYSTEMS
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APPLIED CLINICAL INVESTIGATION
BASIC RESEARCH
DETECTION AND PREVENTION SYSTEMS
1. BILE ACID CLEARANCE 2. BLOOD/TISSUE ENZYMES 3. LEUKOCYTE ADHERENCE INHIBITION 4. HISTOCOMPATIBLE (HL-A) IDENTIFICATION 5. URINARY GLYCOSAMINOGLYCANS 6. TISSUE ANTIGENIC SYSTEMS 7. HISTOLOGICAL/ELECTRON MICROSCOPIC
CHARACTERIZATION 8. MULTIVARIANT ANALYSIS FOR END PRODUCTS 9. IDENTIFICATION OF POTENTIAL CHEMICAL
CARCINOGENS
PATHOGENESIS OF CARCINOGENS
MOLECULAR STRUCTURE VINYL CHLORIDE
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SLIDE 4. The fourth slide illustrates some basic science research being conducted
In the pathogenesis of carcinogens. In this case, they are numbered from 9 through 1 indicating those areas of research most related to the clinical area such as looking for tissue antigen and antibody detection as a means of screening to the most basic one; that Is looking for industrial vinyl monomers by mass spectrometry studies and their metabolites in the carcinogenic'process. These studies are presented In more detail further on. These slides simply illustrate that the inter-disciplinary group is investigating chemical monomers from molecular structure aspects to clinical application.
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