Document aBMQrk9LK4yRXj4BjjwLv5X5a

^#!&AWf-T7l' "---cwy of Scftnees"............. Also on the v1 and loss of SK firm while mi epidermoid cs there was a d microscope. K accounted for invasive grow u hypcrchroniatl j?*Oi.th* 1901 .' who were not t FlCltt Z. tpidemold carcinoma bulging Into lumen of trachea (let!) ixt invading between two tracheal cartilage* (crater) to infiltrate wall of trarht* {right). In the wall, the tumor i* wen as a wirrhou* growth. 176 day* after Start of intratracheal injection* of bento[a]|>yr*he and chryaotile. 100 x. atructed by a 8 x 2 x 2 mm. mass. Microscopically, the tumor in the trache* proved to be a papillary adenocarcinoma (ficuu: 1), and the tumor in tht bronchus was an epidermoid carcinoma. Two hamster* were sacrificed at 190 days, and the last individual I* this group at 214 day*. All seemed in excellent condition at the time of sacrifice. No tumors were found in the two killed at 190 days, but in the 214-day animal a 2.S x 2 v 2 mm. epidermoid carcinoma obstructed the right bronchus. Ormip s. Btmu\n\imr,hr pint tkrymtilr. Three animals died without tumor* at 1, 98, and 108 days respectively. On the 173rd day. a hamstrr was found dead with pneumonia of the right lung and an epidermoid car cinoma in the right bronchus. On the 176th day. a hamster was observed to show rapid, labored respir*linn. He hnd lost 22 grams in weight in the. preceding week. He was **frifioed. The trachea wnx must rioted by a 6 * -I > 3 mm. mass which hail encircled It and Invaded Its wall as shown by a ml surface wideb dl*clonl four tracheal cArtllage* buried In the tumor. Microscopically, this was* scirrhous epidermoid carcinoma that-formed lamellatcd keratin. In the same animal, * l.G x 1 x o.fi mm. broad-based translucent gray mound was seen under the dissecting microscope to be seated on the wall of (he right bronchus. This proved to U- a K-hm differentiated epidermoid rureltmnta. Florin: S. Pa Into lumen. 190 and rhryaolilt. 1 The last nn-njtk gssplng for fflr three mullIlls. nf all four or t trachea that ha had rsrciuoniKK mm. I tttid fifth: lualons Iii tin- t ililtniolri' (bin 8o0d lOS? I".. PRODUCED BV pnnn