Document a4qdkZ14LBj4eQx1QKLmnKgRX

MCA INTEROFFICE MEMO January 12, 1979 Mr. Robert A. Roland Subject: Continuation of Research Program at the School of Medicine, Universityof Louisville The Technical Panel on Vinyl Chloride Research recommends continuation of the multi-component research program on "Research Techniques and Methods of Detection and Prevention of Carcinogenesis in Industrial Workers" at the School of Medicine, University of Louisville for the third year. The total budget includes $287,784 for research and $20,000 for administration. Sixteen companies (see attached) have committed support for continuation of this research. Objectives of the research are the design of methods for early detection, prevention, diagnosis and treatment of those individuals exposed to potentially toxic chemicals with the aim of preventing any serious injury, precancerous lesions, or the development of cancer either on a short- or long-term basis. The program is de signed to identify at the earliest possible time, potentially harm- . ful chemicals and to lead to a reduction in their exposure based on objective chemical data. It is the opinion of the Panel members that if this overall program is to yield optimum results it is important that it be continued. The staff concurs with the recommendation subj,ect to funds becoming available. Attachment APPROVED: A. C. Clark n 0iginal to Miss Tabor Copies: Mr. Van Horn 1,/Hr. Seawell Hr. Clark CMR 2709 Continuation of Research Program at the School of Medicine University of Louisville Sixteen Companies Committed for Support Air Products and Chemicals, Inc. CertainTeed Corporation Continental Oil Company Diamond Shamrock Corporation The Dow Chemical Company Ethyl Corporation The Firestone Tire & Rubber Company The General Tire & Rubber Company, Chemicals/Plastics Division The BFGoodrich Company, Chemical Division Great American Chemical Corporation Hooker Chemical Company The Pantasote Company of New York, Inc PPG Industries, Inc. Shell Oil Company Stauffer Chemical Company Union Carbide Corporation r Cal u ^ f. CMa 27i0 ALBERT C CLARK VICE RESIDENT technical director MANUFACTURING CHEMISTS ASSOCIATION 3;5 C-- wNNe--l^, --, ilC^U-l--i AVENUE N W.....W. *A-SHINGTON DC 20009 'ELER^CNE '202; 329-4240 'ELEX 396V :MCA ,VSnj Subject: Vinyl Chloride Research Program - Continuation of Multi-Component Studies at the University of Louisville The Technical Panel on Vinyl Chloride Research recommends continuation of the multi-component research program being conducted by Dr. C. Tamburro at the School of Medicine, University of Louisville. This research has as its objectives the design of methods for early detection, prevention, diagnosis and treatment of those individuals exposed to potentially toxic chemicals with the aim of preventing any serious injury, precancerous lesions, or the development of cancer either on a short or long-term basis. The program is designed to identify, at the earliest possible time, potentially harmful chemicals and to lead to a reduction in their exposure based on objective chemical data. This is the third year of a three-year research program and it is the view of Panel members that if this overall program is to yield optimum results it is important that con tinuity be preserved. The technical proposal and budget involve three parts: A. Research Techniques and Methods for Detection and Prevention of Carcino genesis in industrial Workers $260,734 B. Whole Body Autoradiographic Study of Vinyl Chloride $ 13,500 C. Vinyl Chloride Metabolism in Isolated Mammalian Liver Cells TOTAL $ 13,550 $287,784 CMA 0027H ------------ C; 2- - Calc--- i Administration costs will be covered by funds remaining from the second year of research. The technical proposal, sent to your company's Technical Representative on October 4, 1978, contains additional informa tion on the type of research being conducted and a breakdown of costs. The attached response form lists your company's maximum pro rata share. Should the number of companies participating be greater than anticipated, your company's share will be reduced proportionately. Work under the second year of research will be completed in February 1979. In an effort toward eliminating the costly interruption of this research, we request that you return the attached commitment form by December 22. Sincerely, cc: Technical Panel CMA 002712