Document a4XgnvqKxOE6e69vv1QX9w88B

HEALTH EFFECTS. HANDLING, AND FIRST AID HEALTH AND ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM DR-0002-5310 HEXACHLOROBENZENE LATEST REVISIONS : OA/29/88 THIS INFORMATION APPLIES TO THE STATED MATERIAL AND MAY NOT APPLY TO DILUTIONS OR FORMULATIONS OF THE MATERIAL. CAS NUMBER: 0000118-7A-1 OTHER IDENTIFIERS: K-002688 SYNONYMS: BENZENE, HEXACHLOROPERCHLOROBENZENE HCB PAGE 1 07/17/89 REPT Z CHEMICAL AND PHYSICAL PROPERTIES THESE DATA COMPILED FROM VARIOUS SOURCES ANO NOT VERIFIED. ADDITIONAL INFORMATION IS AVAILABLE THROUGH YOUR SITE`S REACTIVE CHEMICAL PROGRAM. APPEARANCE: WHITE NEEDLES MOLECULAR WEIGHT: 234.80 SOILING POINT: 322 C MELTING POINT: 229 C {SU8LIMES) VAPOR PRESSURE: 1 MMHG 3 114.4 C FLASH POINT: 242 C STABILITY/REACTIVITY: VERY STABLE -- UNREACTIVE < POTENTIAL HEALTH EFFECTS (REVISED:04/29/88) THIS SECTION INCLUDES POSSIBLE ADVERSE EFFECTS WHICH COULD OCCUR IF THIS MATERIAL IS NOT HANDLED IN THE RECOMMENDED MANNER. C I C - ESSENTIALLY NCNIRRITAT INC TO EYES. | SKIN: - ESSENTIALLY NCNIRRITATING TO SKIN. - A SINGLE PROLONGED EXPOSURE IS NOT LIKELY TO RESULT IN THE MATERIAL BEING ABSORBEO THROUGH SKIN IN HARMFUL AMOUNTS. - THE LD50 FOR SKIN ABSORPTION IN RABBITS IS >2000 MG/KG. - REPEATED SKIN CONTACT PRESENTS A HAZARD OUE TO ACCUMULATION OF HCB IN THE BODY. INGESTION: - SINGLE DOSE ORAL TOXICITY IS LOW. - THE ORAL LD50 FOR RATS IS 3500 MG/KG. - ALTHOUGH SINGLE-DOSE ORAL TOXICITY IS PRESENTS A HAZARD DUE TO ACCUMULATION LOW, INGESTION OF SMALL OF HCB IN THE BODY. AMOUNTS { * TRADEMARK OF ThE DOW CHEMICAL COMPANY RESTRICTED - OOW USE ONLY DO A 039645 OONFTDFNTTAl  HEALTH EFFECTS, HANDLING, AND FIRST AID PAGE 2 HEALTH ANO ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM 07/17/8S 0R-0002-531Q HEXACHLOROBENZENE REPT Z r ACUTE INHALATION EFFECTS: - VAPORS ARE UNLIKELY DUE TO PHYSICAL PROPERTIES. J" - EXPOSURE TO OUSTS MAY CONTRIBUTE TO THE ACCUMULATION OF HCB IN THE BOOY. SUBCHRONIC EFFECTS: - EXCESSIVE EXPOSURE MAY CAUSE NEUROLOGIC SIGNS AND SYMPTOMS. - REPEATEO EXCESSIVE EXPOSURES MAY CAUSE ALTERED BL00D/8ILE PIGMENT METABOLISM (PORPHYRIA) AND LIVER, KIDNEY, SKIN, NERVOUS, SKELETAL, MUSCULAR AND IMMUNE SYSTEM EFFECTS. CHRONIC EFFECTS / CARCINOGENICITY: - HAS BEEN SHOWN TO CAUSE CANCER IN LABORATORY ANIMALS. - FOR HAZARD COMMUNICATION PURPOSES UNOER OSHA STANDARD 29 CFR 1910.1200, THIS CHEMICAL IS LISTED AS A POTENTIAL CARCINOGEN I ARC. PART BY NTP AND TERATOGENIC EFFECTS: - HAS CAUSED BIRTH DEFECTS IN LABORATORY ANIMALS ONLY AT OOSES TOXIC TO THE MOTHER. - HAS BEEN TOXIC TO THE FETUS IN LABORATORY ANIMALS AT DOSES NONTOXIC TO THE MOTHER - TOXICITY TO THE NEONATE BUT NOT BIRTH DEFECTS HAVE OCCURRED IN OFFSPRING OF HUMANS KNOWN TO HAVE INGESTEO TOXIC AMOUNTS OF HEXACHLOROBENZENE. REPRODUCTIVE EFFECTS: '> - IN ANIMAL STUDIES, HAS BEEN SHOWN TO INTERFERE WITH REPRODUCTION . - HCB IS BIOCONCENTRATED IN BOOY FAT AND IS TRANSFERRED TO THE FETUS VIA THE PLACENTA AND TO THE NEONATE VIA LACTATION. - MUTAGENICITY: - RESULTS OF IN VITRO ('TEST TUBE') MUTAGENICITY TESTS HAVE BEEN NEGATIVE. - RESULTS OF MUTAGENICITY TESTS IN ANIMALS HAVE BEEN NEGATIVE. (' V EXPOSURE GUIDELINES HEXACHLOROBENZENE: DOW BIOLOGICAL LIMIT GUIDE IS 150 PPB IN THE BLOOO. THERE IS NO GUIDELINE FOR AIRBORNE CONCENTRATIONS. * TRADEMARK OF THE DOW CHEMICAL COMPANY t i RESTRICTED - DOW USE ONLY 00 A 039646 CONFTDFNTTAt r HEALTH EFFECTS, HANDLING, AND FIRST AID HEALTH AND ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM i ------------------------------------------------------------------------------------------------------------------------------------------------- DR-0002-5310 HEXACHLOROBENZENE PAGE 3 07/17/89 REPT Z r ------------------------------------------------------------------------------------------------------------------------------------------ HANDLING PRECAUTIONS AND PROTECTIVE EQUIPMENT (REVISED:05/06/87) THESE RECOHMENOEO PRECATIONS ARE INTENOEO FOR USE OURING NORMAL OPERATING CONDITIONS: EMERGENCY CONDITIONS CQULO REQUIRE ADDITIONAL PRECAUTIONS. (FOR AN EXPLANATION OF THE LOW, MODERATE AND HIGH POTENTIAL EXPOSURE CATEGORIES OR SPECIFIC RECOMMENDATIONS FOR YOUR SPECIFIC OPERATION CONTACT YOUR INDUSTRIAL HYGIENST.) EYE LOW MOOERATE HIGH -USE SAFETY GLASSES. -USE SAFETY GLASSES. -USE SAFETY GLASSES. SKIN LOW - NO PRECAUTIONS OTHER THAN CLEAN BOOY-COVERING CLOTHING SHOULD BE NEECED. MODERATE - USE PROTECTIVE CLOTHING IMPERVIOUS TO THIS MATERIAL. SELECTION OF SPECIFIC ITEMS SUCH AS GLOVES, BOOTS, APRON, OR FULL-BODY SUIT WILL DEPENO ON OPERATION. HIGH - USE PROTECTIVE CLOTHING IMPERVIOUS TO THIS MATERIAL. SELECTION OF SPECIFIC ITEMS SUCH AS GLOVES, BOOTS, APRON, OR FULL-BODY SUIT WILL DEPEND ON OPERATION. INHALATION LOW - NO RESPIRATORY PROTECTION SHOULD BE NEEOED. MOOERATE - USE AN APPROVED AIR-PURIFYING RESPIRATOR. HIGH - USE AN APPROVEO RESPIRATOR. SELECTION OF AIR-PURIFYING OR POSITIVE-PRESSURE SUPPLIED-AIR WILL DEPEND ON THE SPECIFIC OPERATION AND THE POTENTIAL AIRBORNE CONCENTRATION OF THE MATERIAL. INGESTION - AVOID INGESTION OF EVEN VERY SMALL AMOUNTS; DO NOT CONSUME OR STORE FOOD OR TOBACCO IN THE WORK AREA; WASH HANDS AND FACE BEFORE SMOKING OR EATING. WARNING PROPERTIES: - ODOR IS INADEQUATE WARNING OF EXCESSIVE EXPOSURE. VENTILATION - GOOD GENERAL VENTILATION SHOULD BE SUFFICIENT FOR MOST CONDITIONS PROTECTIVE EQUIPMENT INFORMATION - THE FOLLOWING SHOULO BE EFFECTIVE PROTECTIVE CLOTHING MATERIALS: NEOPRENE, NITRILE BUTADIENE RUBBER. - THERE IS NO RESPIRATOR TEST DATA AVAILABLE FOR THIS CHEMICAL. DATA FOR RELATED CHEMICALS INOICATE THAT THE FOLLOWING SHOULD BE EFFECTIVE TYPES OF AIR-PURIFYING RESPIRATORS: ORGANIC VAPOR WITH DUST PREFILTER. * TRADEMARK OF THE DOW CHEMICAL COMPANY V RESTRICTED DOW USE ONLY DO A 039647 CONFTDHNTTAl f HEALTH EFFECTS, HANDLING, AND FIRST AID HEALTH AND ENVIRONMENTAL SCIENCES T.I.M.E. SYSTEM DR-0002-5310 HEXACHLOROBENZENE PAGE 07/17/BSt REPT Z EMERGENCY TREATMENT AND MEDICAL NOTES REVISED:02/2W88> EYE - IRRIGATE IMMEDIATELY WITH WATER FOR AT LEAST 5 MINUTES. SKIN - WASH OFF IN FLOWING WATER OR SHOWER. INGESTION - INDUCE VOMITING IF LARGE AMOUNTS ARE INGESTED. CONSULT MEDICAL PERSONNEL. INHALATION - REMOVE TO FRESH AIR IF EFFECTS OCCUR. CONSULT A PHYSICIAN. NOTES TO PHYSICIAN: - INDIVIDUALS WITH CHRONIC OR LONG TIME EXPOSURE TO HEXACHLOROBENZENE SHOULD RECEIVE BIOLOGICAL MONITORING OF BLOOD LEVELS. - NO SPECIFIC ANTIDOTE. - SUPPORTIVE CARE. TREATMENT BASED ON JUDGMENT OF THE PHYSICIAN IN RESPONSE TO REACTIONS CF THE PATIENT. - REPEATED EXCESSIVE EXPOSURE MAY AGGRAVATE PREEXISTING LIVER AND KIDNEY DISEASE. ENO OF REPORT; FOR ADDITIONAL INFORMATION CONTACT: CHEMICAL HAZARD EVALUATION AND COMMUNICATION HEALTH AND ENVIRONMENTAL SCIENCES 1803 BUILDING, MIDLAND, MI 48674 PHONE (517) 636-1909 * TRADEMARK OF THE DOW CHEMICAL COMPANY RESTRICTED - OOW USE ONLY 039648 00 A C0NF1 OFNT T Al