Document a4Dbj17Von0DBjRk9J077nM4M

Jan-31-97 06:Q8P Huntingdon Life Sciences P.Ol 4 Huntingdon I Jfa SvitnOM Inc., 1*0 Bnx 2360, Mtttlon Road E*nt Millrtotw, NJ 0*873-2360 USA Tclcphnmi (908) 871.3530 Hx: (908) 8730992 Huntingdon Life Sciences TOTAL NUMBER OF PAGES INCLUDING THIS PAGE: 5 If this transmission is unsatisfactory please contact us by telephone at (908) 873-2550. ATTENTION OF: Dr. Janies B. Knaak FROM: R. E, Schrocder COMPANY. Occidental Chemical Corporation DATE. 31 January 1997 FAX NUMBER: 972-404-3285 CC: Dr. H. Shah CMA 703-741-6091 MESSAGE: 96-4080: Vinyl Chloride Combined Inhalation Two-generation Reproduction and Developmental Toxicity Study in CD rats. Daily chamber exposure data through Week 4. Dear Dr. Knaak, Attached are daily chamber exposure data for the referenced study. The bolded numbers on 9 January, 17 January and 23 January are the GC values. I will be updating you weekly with these data so that you'll have a good idea where we are with the exposure levels. If you have any comments or questions concerning this format please call me or Gary Hoffman. Regards, Raymond E. Schrocder Study Director CMA 118846 CONHIllKINTlAUTY NOTICE! T!ii fix trarumiaiioc may oonlain confidential information Ihat i* legally privileged, The information is intended only fur die use of the recipient named above. Ifyou received thia tax in emir, please notify us immediately by telephone. You are cautioned that .my divulosure. copying, diMribulion or other u*e ofthe traiuniittcd information ii jlricily prohibited. J a n -3 1 -9 7 0 6 :OBP H u n tin g d o n L if e S c ie n c e s P .0 2 Vinyl Chloride Combined Inhalation Two-Generation Reproduction 96-4080 __________and Developmental Toxicity Study in CD Rats _____ Chamber Monitoring Results Cumulative Exposure Record Caoupl- Oppm Week Date ExpOSUR Number 1 7-Ian-97 8-Jan-97 9-Jan-97 10-Jan-97 13-Jan-97 2 14-Jan-97 l 2 3 4 5 6 Mom (ppm) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 * 0.0 0.0 0.0 Miran (1R)` Individual (PPm) 0.0 0.0 00 0.0 0.0 0.0 0.0/1.2 0.0 ` 0.0* 0.0 0.0 00 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 Q.0/L2 0.0 0.0 0.0 0.0 0.0 0.0/0.4 00 0.0 0.0 15-Jan-97 16-Jan-97 17-Jan-97 20-Jan-97 3 21-Jan-97 22-Jan-97 23-Jan-97 24-Jafi4>7 27-Jao-97 7 8 9 10 11 12 13 14 15 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 00 0.0 0.0 0.0 0.0 0.0 0.0 0.0/0.593' 0.0/6.0 * 0 0/0.0 * O.Q/O.O * O.Q/O.O 0.0/0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.f0 0.I0 0.t0 0.0 ome 00/0.0 0.0/0.0 0.0/0.0 O.Q/O.O o.o/o.o 0.0 0.0 0.0 00 0.0 0.0 0,0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4 16 17 18 19 20 0.* SD: 0j 0.0 I * 0JO rf. 1 1 ' 04 0,43 * Bold vafcras indicate GC cooftmatlan of the IR sample Particle Size Determinations MMAD GSD TMC (jim) (mgta3) 3.114 1.714 0.000541 1.812 2.271 0.001290 3 798 2.192 0.002000 Chamber Environment Mean Temperature HwaittiEiL TO (%) 22 41 22 39 23 42 22 49 23 48 22 41 22 40 23 53 22 42 22 39 22 38 23 40 23 42 22 34 22 34 2JQ8: : LOW OW1277 22 LOW . 0.060730 0 . <41 \ 5 * Du* to equipment problems GC sample was not Utaen. ` Mean and SD of al indMckud IR sam(des- ' Mean and SD ofal intfiwtdual GC samples. * Samples taken before die sample line leak was repared. ' Due to equ^ment probtems Mban sample was not taken o DRAFT > CO 00 -& ~v| v 3 a n -3 1 -9 7 0 6 : OSP H u n tin g d o n L if e S c ie n c e s P -0 3 Vinyl Chloride Combined Inhalation Two-Generation Reproduction and Developmental Toxicity Study in CD Rats 96-4080 Chamber Momtcring Results Cumulative Exposure Record Group II -10 ppm Week Date Exposure Number Nominal Mean I 7-Jan-97 JESE2L , (PP"1). 1 9.8 10 8-Jao-97 2 9.8 9.7 9-lan-97 3 9.8 9.5 I0-Jan-97 4 9.8 10 l3-Jan-97 5 9.8 10 2 14-Jan-97 6 9.8 9.7 15-Jan-97 7 9.8 10 16-Jan-97 8 9.8 10 ]7-Jan-97 9 9.4 9.5 20-Jan-97 10 9.8 10 3 21-Jan-97 11 97 12 22-Jan-97 12 9.8 12 23-Jan-97 13 9.8 11 24-Jan-97 14 9.8 11 27-Jan-97 15 98 10 4 28-Jan-97 16 29-Jan-97 17 30-Jan-97 18 31-Jan-97 19 3-Feb-97 20 ,'Meafs: 9.8 10 $D: 1 . o;* - * BcU values indicate CSC confirmation of the IR sample * Due to equipment problems GO sample was not taken. Chamber Concentration Miran (IK * Individual 11 11 9.2 9,8 9.4 k 9.3/14 9.3 99 10 10 9.3 9.9 11 9.9 96 11 7.2/0.95 * 8.0/2.7 * 11 11 12 11 10 14 12/14 11/14 11 11 8.8 11 tECEOl 11 9.9 9.7 11 9 2/13 97/14 9.4 11 10 10 10 10 10 10 10 10 11/2.9* 11/13 9.7 10 12 10 11 1 11/14 11/13 11 11 11 10 9.1 9.0 10/13 11 10 9.6 10 10 10/12 10 13 I 11/13 il 11 - id P : 1.0 - - :ii * 45 8.2 9.4 9.2/14 10 11 9.6 10 10 10/14 11 12 t 11/13 11 11 * Mean and SD ot afl IndMdual IR samples, * Mean and SO of ai indmdual GC samples. Samples taken before the sample fine teak was repaired. Due fo equipment problems Miran sample was not taken. Partkle Size Chamber Environment Determination* Mean MMAD GSD TMC Teranerature Humidity {pm) (mg/m5) 21 <%) 42 1.755 I *87 0 000221 22 42 22 42 22 42 22 42 22 42 2.152 2.555 0.001290 22 42 22 42 22 42 22 33 24 33 1.654 2.049 0001310 22 41 25 42 25 35 24 36 1.834; 0.263 2.164 M0Q94Q 4.006623 23 T 40 1 " ' 4 DRAFT O > 00 00 4*. 00 J n -3 1 -9 7 0 6 ;0 8 P H u n tin g d o n L if e S c ie n c e s Vimi Chloride Combined Inhalation Two-Generalion Reproduction 96-4080 and Developmental Toxicity Study in CP Rats Chamber Monitoring Results Cumulative Exposure Record Group IV -1100 ppm Week Date Exposure Number Nominal Mean 1 7-Jan-97 g-Jan-97 9-Jan-97 10-Jan-97 I3-Jan-97 2 14-Jan-97 15-Jan-97 16-Jan-97 17-Jan-97 I 2 3 4 5 6 7 8 9 (ppm) 1100 1100 1100 1100 1100 1100 noo 1100 1100 (ppm) 1100 1100 1200 HOC 1100 1100 1100 1100 1200 20-Jan-97 3 21-Jan-97 22-Jan-97 23-Jaa-97 24-Jai*97 27-Jan-97 4 28-Jan-97 10 11 12 13 M 15 16 1100 1100 1100 noo 1100 1100 1200 1100 1100 1100 1100 1100 29-Jan-97 17 30-Jan-97 IS 31-Jan-97 3-Feb-97 19 20 : Mean: nop 2130 sb: r 0 41 *BoM values hdkate GC conftrmaban of the IR sx>le * Due to aqufanenl problems GC sample me not taken. Chamber Concentration Miran (UR) Particle Sue Determinations Chamber Environment Mean Individual MMAD GSD TMC Temperature Humifitv (ppm) (pm) (mg/m3) (C) (%) 1200 1100 1100 1100 noo 1100 20 45 noo noo 1200 1200 1100 1100 1.544 1.357 0.000227 20 45 noo* 1200/1200 1100/760 1200/1200 1200/1100 1100/1200 20 45 noo 1100 1100 1100 noo 1100 20 45 1200 1200 1100 noo 1100 noo 20 46 1100 noo noo 1100 1200 1100 20 45 1100 noo noo 1100 noo 1100 1.227 1.345 0.000705 20 39 1100 1100 noo 1100 1100 1100 20 42 1100/894' 1100/1300 1300/1400 1200/1300 1200/1400 1200/13001 20 42 1200 1200 1200 1200 1100 1200 21 43 noo 1100 1100 1200 1200 1100 20 42 1100 1100 noo noo 1200 1100 1.404 1.837 0.001790 21 48 1200/1400 1100/1300 1100/1300 1100/1300 noo/i3to 1100/1300 21 52 1100 1100 1100 1100 noo noo 20 47 noo noo noo noo noo 1100 20 47 1126 v -U 1232 174 1.392 L51J 0/000*9? ' 20 01159 - OL09OM1 .0 45 : / 3J ` Mean and SO of af indhidual 1R sample*. * Mean and SO of al Individual GC samples * Samples taken before the sample line leak was repaved. DRAFT o > 00 GO U CD J a n -3 1 -9 7 0 6 :0 9 P H u n tin g d o n L ir e S c ie n c e s P * 0 5 Vinyl Chloride Combined Inhalation Two-Generation Reproduction 96-4080 and Developmental Toxicity- Study in CD Rats Chamber Monitoring Results Cumulative Exposure Record Group III - 100 ppm Chamber Concentration Particle Size Chamber Enviratuaeiu Week Date Exposure Miran (IR)* Determinations Mean Number Nominal Mean indii idual MMAD GSD TMC Temneraturc Humitfitv 1 7-Jan-97 8-Jao-97 1 2 (PP) Jppm) 94 97 94 100 95 99 ei (pm) fmg/m1) CO 95 100 96 94 100 21 110 too 110 100 100 7.015 2.056 0.001060 20 <%) 40 40 9-Jan-97 3 94 99 99* 96/110 100/110 100/110 100/110 100/120 20 41 10-Jan-97 l3-Jau-97 2 14-Jan-97 4 5 6 94 98 97 97 99 95 100 100 94 no 110 no 110 97 100 110 94 110 110 100 100 110 110 110 21 42 22 48 23 40 l5-Jan-97 7 94 98 93 94 93 110 100 100 3.727 2.495 0.001940 22 39 16-Jan-97 8 94 96 94 93 96 96 98 96 23 57 l7-Jan-97 9 95 100 110/50* 90/90* 110/93* 93/0,0 * 100/37 * 100/110 22 40 20-JM-97 3 2l-Jan-97 22-Jan-97 10 11 12 94 100 100 100 no 110 100 100 22 94 110 100 110 110 100 no 110 20 94 no 110 110 no r 100 100 1.356 1.487 0.001480 21 40 39 43 23-Jan-97 13 94 110 110/120 100/75 100/65* 110/120 110/120 110/120 20 46 24-Jan-97 14 94 99 100 98 100 99 too 98 20 44 27-Jan-97 4 28-Jan-97 15 16 94 100 100 100 100 100 100 100 20 42 29-Jan-97 17 30-Jan-97 18 31-Jan-97 19 3-Feb-97 20 : Mtu: 94 - 192 : O SBi oi 5,6 f 1 Bold values Indicate GC eonflrmatkin ofthe IR sample * Due la equpmert problems GC wnipte was not taken. 102 ie SJt 92 4 35 4.032 2.913 0JW1493 X842 0.00044# 21 I 43 5 ' Mean and SD of all ncAritbat IR samples. 00 00 * Mem and SD at ati indwtdual GC samples. oUl * Samples taken before (he sample ine leakwas repaired ' Due to equipment problems Minn sample was not taken DRAFT 1 Samples taken before a leak in one fitting was discovered and repaired