Document a46myL7wMk22JknOXE740eD1b

.v.'r'.u'j r:..' '.;:t ouah-kAA'AA': ,oh/b.AiSA'aoA .'.-/NTiALd ir. la sa.at/: Jvii.T :/o/.fiio yypihi' oy. at:.;.-. o:: a. .0 ado it:'::'--: ;J ' " i.r'..0 .1 j '..AT/ A, ' GT' jL / . t.9- t . 9 T:. J-J 9 4_t .IT... , ... ........'. . *. LG.1..- .'V. AA-.` ^ J.i L .'./...a .1 . 1 ;<.... ' ;. :d GA .hi.1. 'A.. A,..j.'.V. : ..o A. A.J.-'I/G.1/ r.\ .i /v-0 Gc.'."vr . .A.':--' - ? / - VT/O * v'-li/s. 1 12 ('i) iIAK.lv.Ai GT.LY by Dr F.S. liars (G 0/4 mi i. i r.c ) ^io1. DiocD--r icrl r-re-gct-.s 'nhic ester is probably absorbed with ease from the gnstrc-inbectiml tract and is soluble in plasma. it is hyd:olysed by liver ,md plasma esterases and pancreatic lipase to eHiylalcohol and nco'cate (Cppcnhoi;:.er; 1915; Tasscit, 1963; Zipf, 19-lo| Tic1,Ida, 1957). "hr ctbylr.lcarol is partly encreted in the expired air ar.d urine, the rest Is metabolised, the acetate Traction bcccm-ang incorporated in the body poo] (Fassett, 1963). Animal Route mg/kg bodgveight Refercr.ee rat guinea pig cat oral 3.C. s.c. 5 6.10 , 4 000 (LD) 3 000 Spiector, 1962 Fiury and Wirth, 1933 Fiury mid 'firth, 1933 Dcse3 of 13-115 mg fed dai\y to rats for 5-9 days produced fatty infiltration, of the liver (Sillinger, 1950). The vapour is an irritant to eyes and mucosal surfaces and narcosis can occur from inhalation of a high concentration. There is no evidence of cumulation but secondary anaemia, leucocytes!s and fatty degeneration of viscera have been described as ronic effects (Brewring,' 1965; Ssv, ). The TIL is 400 ppm (fassett, 1963). Exposure to 400-603 ppm for 2-3 hours caused no effects in man (Tatty, 195S). Tho IjEua of this document dai.g not cor.atltuta fori.._ii p-,,c:io:ti;n, it chirkd net fcn iviu\v..d, tAstr'Ctcd or qurh-J wltr.sut Ins aycer.iont of t.i3 \V*\.d Ur.uith O.T^niia.'iOn. Authors r.iono tiro roupOiiJcic for vif-'. J or.prp.jeci in cloned prtioleo. Ce document is* corMi'jc j>5^ urn ppblicP'.on. II rj doit ft-uro I'.-tjol d 'V-cun cu.t.'.Io rericfw 30 rCsumA ni o'auouna citation Gans i`awtorif^ttori oe I'OrflanlsatiOn Mcndicia da In Santd. Les opiniona o>pr!r.i(Sr.u tlnna Ins urt clca s'.^nfig n'rnjagent quo laura auteurs. A$1 00004220  sirs on . 9'.Awea p; curpos ' 1 to Ll.OVt (V- . ;"'iO'O S O' >. ectS Z. FLh/l V '. . -0 uro: A: :l. 0_..d C-'X or 0..10 : A. jor a;- vus i'.ijtr'.el. The l.ato!.. j liity was 93 r.t rid 13 per rent - juive.V;. B remise, . (1965) ^Toxicity of Industrial S olve.it r, 'Elsevi er, Air'sle.rfoj! Fassett, D.W. (H63) In: fatty, F. Industrial Lpgieae ar.G `Toxicology, 2nd cl;, Interscicrce, Lev 'feud: ar.d Lender Firry, F, an.;', 'AirtA, (1933) Arch. Gcwartoputh. Gewerbehyg., 3} 1 Lishidv, h. (1X7) IjXgabu Xsshi, 77, 1141 Oppeaheir.er, C, (1925), Dio feiw.er.te usd ihrer'Jirbange:'., Lei Patty, F.A. (1933) Ir.Avstrj.-j] hygiene and Toxicology, 7ol.Ii Ss;.;, L.I. ( ) Lar.porous Properties of Industrial uateria Lew Tori: and London Sillinpor, O'.I. (1930) lip. i. San., 3, 37 Snyth, H.r. and Anyth, H.F., jr. (1923) J. Ind. ilyg., 10, 16 Spector, >/.A. (196?) L-rndtoo!: of Toxicology Zipf, K. (1920) Arch, f., exper. Path, Pham., 123. 121 ASX 00004221