Document a45rp8J99GEzDwOEdqRBeaV5Y

REPRODUCTION STUDY 96-4080 C-35 APPENDIX C (cant.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 1 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 265 278 274 300 264 277 293 297 296 282 280 255 263 258 244 262 281 296 263 296 284 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 41 161 101.4 18 40 139 89.8 40 35 139 90.3 -31 52 161 97.9 -15 30 141 94.4 -27 44 150 98.0 -26 41 165 100.9 -19 39 160 96.1 -31 52 162 100.0 -15 43 152 97.2 -21 42 153 96.5 -18 32 139 96.9 -29 38 145 99.0 -26 35 141 97.7 -26 35 137 100.8 -19 43 148 102.6 -15 53 164 107.4 -8 47 169 103.4 -19 44 148 102.4 -14 45 160 97.5 -25 38 150 94.3 -18 WT. CHG FROM WEEK 0 41 40 35 52 30 44 41 39 52 43 42 32 38 3S 35 43 53 47 44 45 30 BFG 002465 REPRODUCTION STUDY 96-4080 C-36 APPENDIX C (cont.J VINYL CHLORIDE COMBINED INHALATION TWO-SENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION PREMATINS TREATMENT PERIOD - PI GENERATION WEEK #: I DOSE LEVEL * MALES 10.,0000 PPM ANIMAL NO. 2022 2023 2024 2025 2026 2027 2028 2029 2030 WEIGHT G 305 302 244 285 328 260 278 278 281 NO. OF ANIMALS 30 MEANS STD. DEV. 279.6 19.0 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 50 168 100.0 -22 42 162 96.1 -19 37 138 102.0 -12 43 167 105.6 -21 55 188 104.3 -18 39 143 99.1 -12 47 145 95. D -22 40 149 96.3 -24 37 155 98.4 -27 30 30 30 30 42.0 153.3 98.6 -21.2 6.2 12.1 4.0 6.8 WT. CHG FROM WEEK 0 50 42 37 43 55 39 47 40 37 30 42.0 6.2 BFG 002466 REPRODUCTION STUDY 96-4080 C-37 APPENDIX C (cont.) VINYL CHLORI0E COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 1 DOSE LEVEL 100..0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3008 3009 3010 3011 3012 3013 3014 3015 3016 3017 3018 3019 3020 3021 WEIGHT G 263 286 280 274 279 262 300 267 287 245 285 275 262 289 282 291 307 301 262 265 292 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 37 142 96.8 -29 49 163 103.9 -8 40 143 91.7 29 37 155 101.1 -15 48 158 103.3 -13 41 144 99.4 -18 45 169 101.5 -23 38 140 94.1 -20 46 155 97.9 -16 36 132 96.9 -25 50 156 100.0 -22 32 141 90.7 -34 42 154 41 163 106.5 101.2 -25 -30 38 153 97.0 -21 41 157 96.7 -21 49 178 105.0 -16 42 170 42 154 101.2 106.5 -26 -8 37 145 98.0 -23 50 160 99.9 -22 WT. Cl FROM WEEK 37 49 40 37 48 41 45 38 46 36 50 32 42 41 38 41 49 42 42 37 50 BFG 002467 REPRODUCTION STUDY 96-4080 C-38 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 1 DOSE LEVEL MALES 100..0000 PPM ANIMAL NO. 3022 3023 3024 3025 3026 3027 3028 3029 3030 WEIGHT G 259 281 290 279 259 269 271 266 285 NO. OF ANIMALS 30 MEANS 277.8 STD. DEV. 14.S WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 36 143 98.9 -28 37 153 42 153 97.1 94.8 -39 -32 37 135 86.4 -51 38 150 104.2 -23 42 154 103.5 -18 43 159 106.2 -15 39 161 100.7 -21 41 166 104.6 -30 30 30 30 30 41.2 153.5 99.5 -23.4 4.7 10.7 4.9 8.9 WT. CKG FROM WEEK 0 36 37 42 37 38 42 43 39 41 30 41.2 4.7 BFG 002468 REPRODUCTION STUDY 36-4080 C-39 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK *: 1 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4018 4019 4020 4021 WEIGHT G 266 295 296 297 244 273 269 275 260 253 274 267 286 261 270 303 296 273 249 279 273 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 38 142 95.8 -27 44 164 100.1 -27 54 152 94.2 -13 43 158 95.6 -26 29 136 98.8 -26 33 149 96.8 -26 33 132 BO.7 -57 42 151 99.1 -32 40 139 96.5 -22 40 136 97.3 -15 34 153 99.2 -36 40 163 101.7 -23 50 159 101.5 -10 37 136 93.5 -23 36 144 95.2 -28 40 166 97.8 -23 44 155 94.3 -22 38 142 93.2 -27 41 149 108.7 -2 39 149 95.7 -20 40 153 100.8 -23 WT. CHG FROM WEEK 0 38 44 54 43 29 33 33 42 40 40 34 40 50 37 36 40 44 38 41 39 40 BFG 002469 REPRODUCTION STUDY 96-4080 C-40 APPENOIX C (cont.) VINYL CHLORIDE C0H8INED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 1 DOSE LEVEL - 1100. 0000 PPM MALES ANIMAL NO* 4022 4023 4024 4025 4026 4027 4028 4029 4030 WEIGHT G 266 246 248 276 283 261 253 265 276 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 39 147 99.4 -24 34 129 93.9 -IS 31 137 98.2 -35 37 149 96.4 -35 42 158 100.5 -24 21 142 94.5 -46 33 135 95.1 -29 35 135 90.9 -11 37 162 104.9 -27 WT. CHG FROM WEEK 0 39 34 31 37 42 21 33 35 37 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 272.4 38.1 147.4 97.0 -25.2 38.1 STD. DEV. 16.6 6.2 10.4 4.8 10.5 6.2 BFG 002470 REPRODUCTION STUDY 96-4080 C-41 APPENDIX C (cont.J VINYL CHLORIOE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 1: l DOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1506 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 WEIGHT G 186 171 179 IBS 163 183 197 173 173 178 190 163 171 178 189 182 181 170 186 163 187 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 27 115 111.1 -14 16 107 109.4 -18 19 118 116.0 -12 21 118 110.8 T 16 98 18 108 21 117 105.4 103.4 104.6 -23 -25 -16 17 106 107.4 -21 18 109 110.8 -18 21 105 104.5 -15 27 115 108.6 -11 10 99 104.4 -24 14 103 104.7 -32 20 105 104.2 -19 19 107 99.4 -23 19 114 110.1 -10 18 97 94.0 -26 15 103 29 118 105.6 114.7 -21 -18 20 103 112.2 -10 22 IDS 102.3 -23 WT. Cl FROM WEEK 27 16 19 21 16 18 21 17 IS 21 27 10 14 20 19 19 13 15 29 20 22 BFG 002471 REPRODUCTION STUDY 96-4080 C-42 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREHATING TREATMENT PERIOD - PI GENERATION WEEK I: 1 OOSE LEVEL 0. 0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1526 1529 1530 WEIGHT G 175 181 165 187 168 169 187 165 165 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 20 98 99.0 -26 19 114 110.8 -13 14 99 104.4 -21 18 116 108.6 -19 17 107 111.8 -16 20 108 113.2 -11 25 121 115.6 -24 14 96 103.4 -17 18 105 112.2 -15 I = TECHNICAL PROBLEM WT. CHG FROM WEEK 0 20 19 14 18 17 20 25 14 18 NO. OF ANIMALS 30 MEANS 177.1 30 19.1 30 loe.o 30 107.4 29 -18.7 30 19.1 STD. DEV. 9.7 4.1 7.1 5.2 5.6 4.1 BFG 002472 REPRODUCTION STUDY 96-4080 C-43 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 1 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2506 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 164 178 173 195 183 174 164 160 165 172 182 165 173 163 169 185 174 168 178 169 163 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 7 102 105.9 -34 22 108 107.8 -17 13 97 97.1 -24 24 114 103.8 -10 13 107 101.0 -29 16 100 100.4 -26 15 97 103.3 -28 16 100 109.6 -14 16 108 101.7 -29 20 108 111.1 -15 15 116 110.8 -21 13 91 95.7 -24 23 105 108.4 -22 16 98 105.4 -11 9 97 98.3 -27 11 103 95.6 -30 17 S S S 12 s S s 10 105 101.2 -32 15 103 106.3 -21 10 85 89.7 -31 WT. CHG FROM WEEK 0 7 22 13 24 13 16 15 16 16 20 15 13 23 IS 9 11 17 12 10 15 10 BFG 002473 REPRODUCTION STUDY 96-4080 C-44 APPENOIX C (cunt.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 4: 1 DOSE LEVEL 10..0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 165 191 161 181 185 164 170 164 177 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 18 113 107.0 -21 14 116 105.1 -19 7 98 103.7 T 21 110 107.5 -15 20 114 108.6 -28 15 101 107.6 -18 13 105 24 102 107.0 111.8 -31 18 15 112 110.1 -20 WT. CHG FROM WEEK 0 18 14 7 21 20 15 13 24 15 T - TECHNICAL PROBLEM 5 - SPILLAGE NO. OF ANIMALS 30 30 28 28 27 30 MEANS 173.8 15.3 104.1 104.3 -22.8 15.3 STD. DEV. 9.5 4.7 7.5 5.4 6.7 4.7 BFG 002474 REPRODUCTION STUDY 96-40BO C-45 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK I: 1 fl h-*oo DOSE LEVEL .0000 PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 350S 3506 3507 3503 3509 3510 3511 3512 3513 3514 3515 3516 3517 3513 3519 3520 3521 WEIGHT G 172 163 197 155 167 172 176 171 172 192 161 133 165 163 194 189 151 188 203 174 172 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/OAY G/INT 25 109 113.9 -20 IS 98 105.0 -20 29 119 108.7 -19 19 113 1D7.3 -26 26 103 98.7 -30 23 S S S 23 111 112.5 -14 12 104 105.1 -24 22 101 104.6 -11 30 115 108.3 -13 12 96 103.2 -30 26 117 114.7 -10 21 99 106.8 -29 16 100 107.5 -24 26 113 104.1 -25 24 109 102.6 -21 14 93 25 111 107.6 105.4 -20 T 32 128 114.1 -IS 25 108 111.5 -22 22 107 110.8 -24 WT. Cl FROM WEEK 25 15 29 19 26 23 23 12 22 30 12 26 21 16 26 24 14 25 32 25 22 BFG 002475 REPRODUCTION STUDY 96-4080 C-46 APPENDIX C (cont.J VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK t: 1 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 HEIGHT G 167 180 183 181 195 181 184 169 174 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 23 103 110.4 -12 22 100 98.6 -21 17 107 102.2 -27 24 127 125.2 -7 22 116 105.1 -31 24 107 105.5 -14 27 125 122.2 -19 22 97 102.3 -16 7 145 141.7 T WT. CHG. FROM WEEK 0 23 22 17 24 22 24 27 22 7 T - TECHNICAL PROBLEM S SPILLAGE NO. OF ANIMALS 30 30 29 29 27 30 MEANS STD. DEV. 178.1 12.1 21.8 5.7 109.7 11.4 109.2 8.7 -20.3 6.6 21.8 5.7 BFG 002476 REPRODUCTION STUDY 36-4080 C-47 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: l DOSE LEVEL 1100..0000 PPM FEMALES ANIMAL NO. 4501 4502 4503 4504 4505 4506 4507 4508 4509 4510 4512 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 WEIGHT G 175 190 170 173 133 187 176 159 163 181 163 172 174 163 188 186 161 189 173 173 171 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 99 98.2 -29 29 108 102.6 -38 22 111 116.4 -18 14 100 100.4 -35 14 s S S 14 98 90.7 -30 11 103 99.5 T 9 93 100.3 -25 12 92 97,7 -24 27 106 105.5 -21 19 101 109.7 -24 9 104 103.5 -29 17 103 103.7 T 16 S S S 18 108 100.6 -25 21 100 95.0 -29 21 105 102.6 -22 26 114 108.0 -19 26 100 104.2 -9 19 109 111.1 -17 19 109 112.5 -24 WT. CHG FROM WEEK 0 14 29 22 14 14 14 11 9 12 27 19 9 17 16 18 21 21 26 26 19 19 BFG 002477 REPRODUCTION STUDY 96*4080 C-48 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 1 OOSE LEVEL - 1100.0000 PPM FEMALES ANIMAL NO. 4522 4S23 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 181 169 175 177 192 189 168 166 166 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 23 111 109.1 -30 19 100 104.5 -18 17 S S S 20 117 116.8 -25 26 118 109.9 -15 31 123 118.2 -14 20 104 109.7 -18 16 103 108.6 -19 15 103 108.3 -28 T * TECHNICAL PROBLEM WT. CHG FROM WEEK 0 23 19 17 20 26 31 20 16 15 S SPILLAGE NO. OF ANIMALS 30 MEANS 175.8 STD. DEV. 9.3 30 18.8 5.7 27 105.3 7.3 27 105.4 6.7 25 -23.4 6.8 30 18. B 5.7 BFG 002478 REPRODUCTION STUDY 96-40BO C-49 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL 0..0000 PPM MALES ANIMAL NO. 1001 1002 1003 1004 1005 1006 1007 1003 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 WEIGHT G 309 284 307 339 323 298 282 313 337 304 278 335 323 301 290 324 333 300 331 311 323 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 37 152 87.2 6 -19 109 61.9 -46 40 147 85.4 4 52 158 84.1 3 44 143 79.2 -15 37 143 85.3 -6 29 136 84.7 4 43 154 86.6 12 56 179 96.5 19 39 145 64.9 0 29 138 87.3 -18 51 180 96.9 21 36 151 82.5 -2 36 139 81.9 4 47 149 93.2 15 54 169 94.8 12 50 159 86.0 6 37 148 87.6 3 38 165 38.1 -1 43 150 86.4 2 48 162 90.3 12 WT. CHG FROM WEEK 0 75 34 77 96 69 72 68 S3 104 74 67 102 73 71 60 103 88 71 84 77 91 BFG 002479 REPRODUCTION STUDY 96-4080 C-50 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL * 0..0000 PPM MALES ANIMAL NO. 1022 1023 1024 1025 1026 1027 1028 1029 1030 WEIGHT G 309 318 313 320 318 319 318 334 326 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/DAY G/INT 41 152 87.8 7 37 155 86.3 12 32 151 84.7 5 42 157 87.5 8 43 161 90.5 S 38 167 92.8 17 51 160 91.2 14 42 159 84.7 8 36 157 85.0 3 WT. CHS FROM WEEK 0 89 71 78 90 82 84 97 83 73 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 314.2 39.6 153.2 86.7 3.5 80.9 STD. DEV. 16.5 13.1 13.6 6.3 12.9 13.8 BFG 002480 REPRODUCTION STUDY 96-4080 C-51 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 332 318 323 354 300 320 335 341 350 316 325 266 305 293 278 300 325 346 305 346 328 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 47 164 68.6 3 40 146 81.7 7 49 152 84.9 13 54 175 89.2 14 36 141 83.3 0 43 161 89.9 11 42 163 86.5 -2 44 167 87.3 7 54 177 91.3 15 34 162 45 164 90.3 90.4 10 11 31 144 88.7 5 42 154 90.4 9 35 147 34 141 86.9 90.0 6 4 38 161 44 167 95.5 91.9 13 3 50 181 94.0 12 42 157 50 174 44 155 92.1 90.3 84.4 9 14 5 WT. CHG FROM WEEK 0 86 80 84 106 66 87 83 83 106 77 87 63 80 70 69 81 97 97 86 95 82 BFG 002481 REPRODUCTION STUDY 96-4080 C-52 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 OQSE LEVEL - 10..0000 PPM MALES ANIMAL NO. 2022 2023 2024 2025 2026 2027 2028 2029 2030 WEIGHT G 353 339 287 324 380 293 320 315 326 HEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 48 175 88.7 7 37 155 80.6 -7 43 151 94.8 13 39 174 S5.2 7 52 193 90.9 5 33 155 93.4 12 42 161 89.7 16 37 148 53.2 -I 45 168 92.3 13 UT. CHG FROM UEEK 0 98 79 80 82 107 72 89 77 82 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 322.1 42.5 161.1 89.3 7.8 84.4 STO. DEV. 23.5 6.3 12.6 3.9 5.6 11.3 REPRODUCTION STUDY 96-4030 C-53 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 OOSE LEVEL - 100..0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3008 3009 3010 3011 3012 3013 3014 3015 3016 3017 3013 3019 3020 3021 WEIGHT G 306 341 319 323 329 307 333 307 337 280 328 300 307 339 328 344 3S2 343 306 310 348 WEIGHT FOOD 'CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 43 158 92.6 16 55 181 96.2 18 39 146 81.2 3 49 169 94.4 14 SO 169 92.7 11 45 149 87.3 5 38 172 89.9 3 40 149 86.5 9 50 176 94.0 21 35 141 89.5 9 43 167 90.8 11 25 140 81.2 -1 45 164 96.1 10 SO 178 94.5 15 46 164 89.6 11 S3 169 88.7 12 45 181 91.6 3 42 174 90.1 4 46 167 97.7 13 45 154 89.3 9 56 174 90.6 14 WT. CHG FROM WEEK 0 80 104 79 86 98 86 83 78 96 71 93 57 87 91 84 94 94 84 88 B2 106 BFG 002482 REPRODUCTION STUDY 96-4080 C-54 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 2 OOSE LEVEL - 100..0000 PPM MALES ANIMAL NO. 3022 3023 3024 3025 3026 3027 3028 3029 3030 WEIGHT G 298 318 330 323 295 321 30S 332 336 NO. OF ANIMALS 30 MEANS 321.7 STD. DEV. 17.9 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 39 151 90.4 8 37 161 89.6 8 40 163 87.6 10 44 159 88.0 24 36 162 97.5 12 52 175 98.9 21 34 163 94.3 4 46 167 51 180 90.1 96.6 6 14 30 30 30 30 44.0 164.1 91.2 10.6 6.9 11.6 4.3 5.9 WT. CHG FROM WEEK 0 75 74 82 81 74 94 77 85 92 30 85.2 10.2 BFG 002483 REPRODUCTION STUDY 96-4000 C-55 APPENDIX C (cant.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL 1100,.0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4006 4009 4010 4011 4012 4013 4014 4015 4016 4017 4016 4019 4020 4021 WEIGHT G 314 334 357 339 269 326 336 327 294 306 333 342 343 307 311 349 344 314 288 327 323 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT 46 155 89.1 13 39 161 85.3 -3 61 177 90.4 25 42 156 82.8 0 45 151 94.4 15 53 162 90.2 13 47 156 83.2 24 52 167 92.5 16 34 135 81.2 .4 53 153 91.2 17 59 168 92.3 15 55 175 92.7 12 57 173 91.7 14 46 150 88.0 14 41 ISO 86.1 6 46 165 46 175 84.4 91.1 -1 20 41 146 82.9 4 39 151 93.7 2 48 153 84.2 4 50 168 94.0 15 WT. Cl FROM WEEK 86 83 115 85 74 86 80 94 74 93 93 95 107 83 77 86 92 79 80 87 90 BFG 002484 REPRODUCTION STUDY 96-4080 C-56 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK I: 2 DOSE LEVEL - 1100.,0000 PPM MALES ANIMAL NO. 4022 4023 4024 4025 4026 4027 4028 4029 4030 WEIGHT G 306 284 284 315 336 306 297 302 317 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 40 152 88.6 5 38 141 88.7 12 36 139 87.1 2 39 157 86.6 8 53 190 1D2.3 32 45 140 82.3 -2 44 148 89.7 13 37 151 88.8 16 41 170 95.6 8 WT. CHG FROM WEEK 0 79 72 67 76 95 66 77 72 78 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 318.3 45.9 157.9 89.1 10.5 84.0 STD. DEV. 20.5 7.1 12.9 4.7 8.8 11.0 BFG 002485 REPRODUCTION STUDY 96-4080 C-57 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 ISIS 1516 1517 1518 1519 1520 1521 WEIGHT G 208 189 210 211 176 197 21B 195 196 199 204 186 196 200 208 206 202 190 203 182 204 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 22 124 104.9 9 18 106 100.0 1 31 125 107.1 7 23 122 101.9 4 13 104 102.3 6 14 110 96.5 2 21 124 99.6 7 22 113 102.4 7 23 118 106.6 9 21 113 99.9 6 14 121 102.4 6 23 104 99.3 5 25 111 100.6 8 22 110 97.0 5 19 110 92.4 3 24 123 105.7 9 21 113 98.3 16 20 106 96.1 3 17 118 101.1 0 19 114 110.1 11 17 111 94.6 3 WT. CHG FROM WEEK 0 49 34 50 44 29 32 42 39 41 42 41 33 39 42 38 43 39 35 46 39 39 BFG 002486 REPRODUCTION STUDY 96-4080 C-59 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK #: 2 OOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1528 1529 1530 WEIGHT G 187 211 184 200 184 190 209 172 176 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 103 30 133 94.8 113.1 5 19 19 110 105.1 11 13 119 102.5 3 16 112 106.1 5 21 112 104.0 4 22 131 110.3 10 7 100 98.9 2 11 155 151.5 50 WT. CHG FROM WEEK 0 32 49 33 31 33 41 47 21 29 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STO. DEV. 196.4 11.9 19.3 5.3 115.9 11.0 103.6 10.3 7.9 9.0 38.4 6.B bfg 002487 REPRODUCTION STUDY 96-4080 C-59 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TVO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2508 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 189 193 198 219 207 199 186 184 205 192 205 185 184 192 203 208 202 201 205 195 182 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE 5 G/m G/K6/DAY s/m 25 117 110.5 15 15 113 101.5 5 25 109 97.9 12 24 124 99.8 10 24 110 94.0 3 25 119 106.3 19 22 105 100.0 8 24 107 103.7 7 20 119 101.7 11 20 113 103.5 5 23 117 100.8 1 20 110 104.8 19 11 101 94.3 -4 29 110 103.3 12 34 118 105.7 21 23 115 97.5 12 28 133 117.9 T 33 128 115.6 T 27 123 107.0 18 26 116 108.1 15 19 99 95.7 14 WT. CHG. FROM WEEK 0 32 37 38 48 37 41 37 40 36 40 38 33 34 45 43 34 45 45 37 41 29 BFG 002488 REPRODUCTION STUDY 96-4090 C-60 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-SENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK I: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 2 DOSE LEVEL 10,.0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 211 214 194 211 2 02 178 189 192 193 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 26 125 105.2 12 23 122 100.4 6 33 115 108.0 17 30 120 102.0 10 17 120 103.4 6 14 no 107.2 9 19 113 104.9 8 28 115 107.7 13 16 119 107.2 7 T * TECHNICAL PROBLEM WT. CHG. FROM WEEK 0 44 37 40 51 37 29 32 52 31 NO. OF ANIMALS 30 MEANS 197.3 STD. OEV. 10.4 30 23.4 5.7 30 115.6 7.6 30 103.9 5.5 28 10.4 5.8 30 38.8 6.0 BFG 002489 REPRODUCTION STUDY 96-4080 C-61 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL 100. OOOO PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3506 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 191 186 226 200 207 193 186 197 193 217 184 204 1B4 1B5 206 200 168 207 233 197 190 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 19 118 108.4 9 25 113 107.3 15 29 132 104.0 13 15 113 97.8 0 20 119 100.7 16 21 161 147.0 T 12 110 100.7 -1 26 111 100.5 7 21 112 102.3 n 25 123 100.2 8 23 121 116.9 25 21 130 112.0 13 19 109 104.1 10 22 119 114.0 19 14 119 98.7 6 11 107 91.7 -2 17 105 109.7 12 19 118 99.6 7 30 139 106.3 11 23 118 106.0 10 16 114 105.0 7 WT. Cl FROM WEEK 44 40 56 34 46 44 35 36 43 55 35 47 40 38 40 35 31 44 62 48 40 BFG 002490 REPRODUCTION STUDY 96-4080 C-62 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK t: 2 oo DOSE LEVEL 0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 WEIGHT G 186 199 194 206 226 198 212 190 202 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 19 108 102.0 5 19 no 96.7 10 11 116 102.6 9 25 132 113.7 5 31 140 110.8 24 17 117 102.9 10 28 125 105.2 0 21 112 104.0 15 28 121 107.3 -24 WT. CHG FROM WEEK 0 42 41 28 49 53 41 55 43 35 T - TECHNICAL PROBLEM NO. OF ANIMALS 30 MEANS 199.1 30 21.0 30 119.7 30 105.9 29 8.6 30 42.8 STD. DEV. 14.1 5.4 11.9 9.5 9.0 8.0 BFG 002491 REPRODUCTION STUDY 96-4080 C-63 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 2 DOSE LEVEL 1100. OOOO PPM FEMALES ANIMAL NO. 4501 4502 4503 4504 4505 4;jQ6 4507 4506 4509 4510 4511 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 WEIGHT G 205 202 187 208 213 200 205 183 181 199 184 190 171 189 217 202 196 209 190 202 191 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 30 122 107.0 23 12 111 94.4 3 17 112 104.6 1 35 125 109.4 25 30 142 119.5 T 13 107 92.2 9 27 112 97.5 9 24 107 104.3 14 18 94 18 119 91.1 104.4 2 13 21 115 110.5 14 18 114 105.0 10 -3 81 78.3 -22 26 106 100.4 T 29 121 99.6 13 16 109 93.6 9 15 114 100.8 9 20 124 103.9 10 17 111 101.9 11 29 128 113.8 19 20 116 106.8 7 WT. CHG FROM WEEK 0 44 41 39 49 44 27 38 33 30 45 40 27 14 42 47 37 36 46 43 48 39 BFG 002492 REPRODUCTION STUDY 96-4080 C-64 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 4: 2 DOSE LEVEL * 1100..0000 PPM FEMALES ANIMAL NO. 4522 4523 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 209 186 201 203 219 209 189 183 191 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 28 123 105.1 12 17 105 26 131 98.6 116.1 5 T 26 132 115.8 15 27 136 110.3 18 20 127 106.4 4 21 119 111.1 15 17 114 108.9 11 25 115 107.4 12 WT. CHG FROM WEEK 0 51 36 43 46 53 SI 41 33 40 T * TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 27 30 MEANS 197.1 21.3 116.4 103.9 10.0 40.1 STD. DEV. 11.7 7.4 12.2 8.6 8.6 8.3 BFG 002493 REPRODUCTION STUDY 96-4060 C-65 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL 800Y WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 WEIGHT G 335 340 335 369 363 334 307 355 379 338 306 379 354 341 325 363 367 335 364 346 357 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 26 150 77.6 -2 56 138 73.7 29 28 149 77.4 2 30 160 75.3 2 40 160 77.7 17 36 153 80.7 10 25 131 74.1 -5 37 154 76.3 0 42 179 83.3 0 34 150 77.9 5 28 137 78.2 -1 44 181 84.S 1 31 157 77.3 6 40 152 78.9 13 35 154 83.5 5 39 174 64.4 5 34 166 79.0 7 35 151 79.3 3 33 165 79.1 0 35 147 74.6 -3 34 160 76.4 -2 WT. CHG FROM WEEK 0 101 90 105 126 129 108 93 120 146 108 95 146 104 111 115 142 122 106 117 112 125 BFG 002494 REPRODUCTION STUDY 96-4080 C-66 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK t: 3 DOSE LEVEL 0,.0000 PPM MALES ANIMAL NO. 1022 1023 1024 1025 1026 1027 1028 1029 1030 WEIGHT G 350 347 349 351 337 350 355 373 360 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 41 157 79.4 5 29 144 72.2 -11 36 152 76.5 1 31 163 01.0 6 19 154 78.4 -7 31 159 79.2 -8 37 170 84.2 10 39 165 77.8 6 34 154 74.8 -3 WT. CHG. FROM WEEK 130 100 114 0 121 101 115 134 122 107 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 346.6 34.6 156.2 78.5 3.0 115.5 STD. DEV. 18.0 5.8 11.4 3.2 7.8 14.9 BFG 002495 REPRODUCTION STUDY 96-4030 C-67 APPENDIX C fcont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL - 10..0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2003 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 363 345 367 400 332 356 365 374 393 346 352 323 334 329 308 335 376 388 346 379 361 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G7INT 31 158 75.8 -6 27 144 44 159 72.4 76.8 -2 7 46 179 79.1 4 32 141 74.4 0 36 156 77.9 -3 30 160 76.2 -3 33 166 43 177 30 153 78.3 79.4 77.0 1 0 -9 27 160 78.0 -4 37 148 81.0 4 29 146 76.2 -8 36 155 83.1 8 30 143 81.3 2 35 164 86.1 3 51 180 65.6 13 42 181 82.2 0 41 157 80.4 0 33 172 79.1 -2 33 158 76.4 3 WT. Cl FROM WEEK 119 107 128 152 98 123 113 116 149 107 114 100 109 106 99 116 148 139 127 128 115 BFG 002496 REPRODUCTION STUDY 96-4080 C-68 APPENDIX C (cant.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK /: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 3 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2022 2023 2024 2025 2026 2027 2028 2029 2030 WEIGHT G 397 373 318 361 426 320 352 349 363 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 44 180 34 162 60.0 75.8 5 7 31 151 83.2 0 37 169 82.2 -5 46 198 81.9 5 27 147 79.9 -8 32 151 74.9 -10 34 147 37 171 73.8 82.7 -1 3 WT. CHG FROM WEEK 0 142 113 111 119 153 99 121 111 119 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 357.7 27.2 35.6 6.4 161.2 13.8 79.1 3.5 0.1 5.4 120.0 16.1 BFG 002497 REPRODUCTION STUDY 96-4080 C-69 APPENDIX C (cant.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3006 3009 3010 3011 3012 3013 3014 3015 3016 3017 3018 3019 3020 3021 WEIGHT G 345 380 354 355 377 341 380 344 379 312 364 334 344 376 361 382 388 360 351 345 390 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 39 169 86.5 11 39 183 84.6 2 35 154 76.3 8 32 167 48 183 82.1 86.4 -2 14 34 153 78.7 4 42 173 80.3 1 37 154 78.9 5 42 175 81.5 -1 32 149 83.9 8 36 169 81.4 2 34 154 81.0 14 37 161 82.4 -3 37 176 82.1 -2 33 157 76.0 -7 38 176 80.8 7 36 190 85.6 9 37 177 81.6 3 43 175 86.5 8 35 156 79.4 2 42 175 79.0 1 WT. CHG FROM WEEK 0 119 143 114 118 146 120 125 115 138 103 129 91 124 128 117 132 130 121 131 117 148 BFG 002498 REPRODUCTION STUDY 96-4060 C-70 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK t: 3 DOSE LEVEL - 100..0000 PPM MALES ANIMAL NO. 3022 3023 3024 3025 3026 3027 3026 3029 3030 WEIGHT G 331 346 352 359 316 3S7 340 365 367 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 33 152 80.6 1 2B 158 79.3 -3 22 155 75.8 -8 36 168 82.1 9 21 153 83.5 -9 36 181 89.0 6 35 177 91.5 14 33 171 81.8 4 31 177 83.9 -3 30 30 30 30 WT. CHG FROM WEEK 0 108 102 104 117 95 130 112 118 123 30 MEANS 357.2 35.4 167.3 82.1 3.2 120.6 STO. DEV. 20.4 5.6 11.6 3.8 6.3 13.9 BFG 002499 REPRODUCTION STUDY 96-4080 C-71 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL * 1100.,0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4018 4019 4020 4021 WEIGHT G 339 374 393 368 313 353 370 356 322 333 370 377 384 340 342 387 370 345 320 365 340 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 25 152 77.6 -3 40 166 79.1 7 36 175 77.8 -2 29 158 74.5 0 24 155 as.8 4 27 165 81.0 3 34 171 80.7 15 29 162 79.1 -5 28 141 76.3 6 27 153 79.8 0 37 173 82.0 5 35 180 41 175 83.4 80.2 5 2 33 156 80.4 6 31 158 80.7 8 38 176 26 168 79.7 78.4 11 -7 31 149 75.4 3 32 151 82.8 0 38 255 74.7 2 17 159 79.9 -9 WT. CHG. FROM WEEK 0 111 123 151 114 96 113 114 123 102 120 130 130 148 116 108 124 118 110 112 125 107 BFG 002500 REPRODUCTION STUDY 96-4060 C-72 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 OOSE LEVEL 1100..0000 PPM MALES ANIMAL NO. 4022 4023 4024 402S 4026 4027 4028 4029 4030 WEIGHT G 334 302 307 345 372 328 316 321 354 NO. OF ANIMALS 30 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G7INT G/KG/OAY G/INT 28 153 79.7 1 18 139 79.1 -2 23 146 82.3 7 30 165 83.3 8 36 184 86.6 -6 22 147 77.3 7 19 145 78.8 -3 19 146 78.1 -5 37 188 93.4 18 30 30 30 30 WT. CHG FROM WEEK 0 107 90 90 106 131 88 96 91 115 30 MEANS STO. DEV. 348.0 25.3 29.7 6.B 160.4 13.1 80.3 3.8 2.5 6.3 113.7 15.6 BFG 002501 REPRODUCTION STUDY 96-4080 C-73 APPENOIX C (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK t: 3 DOSE LEVEL - 0.0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 WEIGHT G 213 206 226 226 198 211 225 215 216 217 226 197 206 222 224 230 224 205 221 190 222 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 5 115 17 105 16 120 91.1 88.6 91.7 -9 -3 -5 15 111 84.7 -11 22 111 14 114 7 118 96.9 93.1 88.8 7 4 -6 20 121 96.4 S 20 113 91.4 -5 18 115 92.1 2 22 127 98.4 6 11 105 10 106 91.4 87.9 1 -5 22 119 94.0 9 16 109 84.1 -1 24 130 99.4 7 22 117 91.5 4 15 111 18 126 93.7 99.1 5 8 8 101 90.5 -13 18 117 91.5 6 WT. CHG FROM WEEK 0 54 51 66 59 51 46 49 59 51 60 63 44 49 64 54 67 61 50 64 47 57 BFG 002502 REPRODUCTION STUDY 96-4080 C-74 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL - 0,.0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1528 1529 1530 WEIGHT G 204 234 207 221 199 196 221 193 200 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G 6/INT G/KG/OAY G/INT 17 108 92.1 5 23 134 100.4 1 23 114 97.2 4 21 127 100.6 8 15 116 101.0 4 6 106 91.5 -6 12 133 103.1 2 21 109 99.5 9 24 116 102.8 -39 WT. CHG FROM WEEK 0 49 72 56 52 48 47 59 42 53 NO. OF ANIMALS 30 MEANS 213.2 STD. DEV. 12.3 30 16.7 5.6 30 115.8 8.6 30 94.3 5.2 30 -0.1 9.6 30 55.1 7.6 BFG 002503 REPRODUCTION STUDY 96-4080 C-75 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TW-6ENERATI0N REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK # r 3 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2508 2509 2510 2511 2512 2513 2514 251S 2516 2517 2518 2519 2520 2521 WEIGHT G 201 208 211 233 217 217 197 190 218 200 206 194 207 209 206 224 209 212 221 210 199 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 118 100.9 1 15 116 96.4 3 13 108 88.0 -1 14 125 92.2 1 10 111 18 121 87.3 97.0 1 2 11 106 92.3 1 6 102 90.9 -5 13 118 93.0 -1 8 11S 97.8 2 1 111 90.0 -6 9 104 23 no 91.5 93.8 -6 9 17 114 94.8 4 3 114 92.9 -4 16 114 88.0 -1 7 136 110.3 3 11 128 103.3 0 16 123 96.2 0 15 115 94.7 3 17 93 81.4 -6 WT. CHG FROM WEEK 0 44 52 51 62 47 59 48 46 49 48 39 42 57 62 46 50 52 56 53 56 46 BFG 002504 REPRODUCTION STUDY 96-4080 C-76 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL - 10..0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 226 225 214 204 222 194 203 206 211 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 117 89.2 -8 11 118 89.6 -4 20 121 98.9 6 -7 109 87.6 -11 20 134 105.3 14 16 112 100.4 2 14 118 100.3 5 14 11S 96.3 0 18 122 100.7 3 WT. CHG FROM WEEK 0 59 48 60 44 57 45 46 66 49 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 209.8 12.5 115.6 94.7 0.0 51.3 STD. DEV. 10.5 6.2 8.9 6.2 5.1 6.7 BFG 002505 REPRODUCTION STUDY 96-4080 C-77 APPENDIX C (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREH4T2NG TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL 100,.0000 PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3508 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 218 200 243 210 217 204 211 218 214 234 193 224 190 198 227 231 183 215 253 206 209 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 27 133 108.4 15 12 108 92.8 -5 17 134 95.2 2 10 113 91.9 0 10 118 92.8 -1 11 123 103.3 -38 23 122 101.9 12 21 121 97.2 10 21 119 97.5 7 17 128 94.6 5 9 114 100.8 -7 20 124 96.6 -6 6 104 92.7 -5 13 115 100.1 -4 19 118 90.4 -1 31 lie 91.3 11 15 102 96.9 -3 8 112 88.5 -6 20 136 93.3 -3 9 117 96.8 -1 19 119 99.4 5 WT. CHG FROM WEEK 0 71 52 75 44 56 55 58 59 64 72 44 67 46 51 59 66 46 52 82 57 59 BFG 002506 REPRODUCTION STUDY 96-4080 C-78 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK #: 3 DOSE LEVEL - 100..0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 WEIGHT G 197 197 215 223 247 217 223 203 213 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 11 109 -2 102 21 120 94.9 85.9 97.8 1 -8 4 17 133 103.3 1 21 142 19 124 100.1 99.6 2 7 11 147 112.6 22 13 106 89.9 -6 11 127 102.0 6 UT. CHG FROM WEEK 0 53 39 49 66 74 60 66 56 46 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 214.4 15.3 120.3 96.9 0.5 58.1 STD. DEV. 16.6 6.8 11.3 5.8 10.2 10.6 BFG 002507 REPRODUCTION STUDY 96-4080 C-79 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION THO-GENERAT10N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL 800Y HEIGHT AND FOOD CONSUMPTION PRWATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL - 1100.OOOQ PPM FEMALES ANIMAL NO. 4501 4502 4503 4504 4505 4506 4507 4508 4509 4510 4511 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 HEIGHT G 225 224 196 215 231 213 220 199 190 218 201 201 191 200 236 221 206 218 207 210 210 HEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT 20 129 100.0 7 22 123 96.2 12 9 123 107.0 11 7 119 93.8 -6 18 S S S 13 104 83.9 -3 15 122 95.7 10 16 115 100.3 8 9 100 89.8 6 19 124 17 122 99.1 105.6 5 7 11 112 95.5 -2 20 100 92.1 19 11 108 19 131 92.5 96.4 2 10 19 110 86.7 1 10 106 89.6 -6 9 107 83.5 -17 17 111 93.2 0 8 122 98.7 -6 19 120 99.8 4 HT. CHG. FROM UEEK 0 64 63 48 56 62 40 53 49 39 64 57 38 34 53 66 56 46 55 60 56 58 BFG 002508 REPRODUCTION STUDY 96-4080 C-80 APPENDIX C (cont.) VINYL CHLORIDE CQM8INED INHALATION THO-SENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 3 DOSE LEVEL 1100. 0000 PPM FEMALES ANIMAL NO. 4522 4523 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 219 197 216 219 238 227 212 204 202 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/IN7 G/KS/DAY G/INT 10 127 98.9 4 11 106 92.3 1 15 119 95.1 -12 16 135 106.6 3 19 137 99.9 1 18 135 103.2 8 23 128 106.4 9 21 121 104.2 7 11 121 102.6 6 WT. CHG FROM WEEK 0 61 47 58 62 72 69 64 54 51 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 212.2 15.1 118.6 96.9 3.1 55.2 STD. OEV. 12.7 4.7 10.4 6.5 7.6 9.4 BFG 002509 REPRODUCTION STUDY 96-4080 C-81 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-SENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1001 1002 1003 1004 1005 1006 1007 1006 1009 1010 1011 1012 1013 1014 1015 1016 1017 1016 1019 1020 1021 WEIGHT G 363 386 364 393 399 354 326 381 412 355 322 416 372 365 355 402 399 357 389 380 375 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 28 151 72.1 1 46 170 78.1 32 29 150 71.5 1 24 157 68.7 -3 36 170 74.4 10 20 150 72.7 -3 19 133 72.7 7 26 158 71.6 4 33 177 74.6 -2 17 142 68.3 -3 16 142 75.4 5 37 179 75.1 -2 18 142 65.2 -15 24 147 69.4 -5 30 156 76.5 2 39 177 77.1 3 32 166 73.1 2 22 150 72.3 -1 25 167 73.9 2 34 160 73.5 13 16 157 71.5 -3 WT. Cl FROM WEEK 129 136 134 150 165 126 112 146 179 125 111 183 122 135 145 131 154 128 142 146 143 BFG 002510 REPRODUCTION STUDY 96-4080 C-S2 APPENDIX C {cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1022 1023 1024 1025 1026 1027 1028 1029 1030 WEIGHT G 374 363 371 386 356 373 384 406 381 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 156 71.8 -1 16 144 67.6 0 22 151 69.9 -1 35 174 78.7 11 19 154 74.1 0 23 156 71.9 -3 29 164 74.0 -6 33 174 74.5 9 21 158 71.1 4 WT. CHG FROM WEEK 0 154 116 136 156 120 138 163 155 128 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 375.3 26.5 158.0 72.7 1.8 142.0 STD. OEV. 22.4 7.7 11.7 3.1 8.2 19.4 BFG 002511 REPRODUCTION STUDY 96-4080 C-83 APPENDIX C (cont.) VINYL CHLORIDE COWINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 OOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2006 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 388 359 395 438 355 385 404 397 426 370 362 343 359 357 332 360 396 427 375 406 384 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 25 165 14 140 73.2 66.3 7 -4 2B 158 69.1 -1 38 181 72.0 2 23 142 68.9 1 29 152 66.4 -6 39 167 72.4 7 23 162 70.0 -6 33 185 75.3 8 24 157 73.1 4 10 148 69-1 -12 20 150 75.1 2 25 149 71.7 3 28 156 75.8 1 24 146 76.0 3 25 165 79.1 1 20 175 75.6 -5 39 186 76.1 5 29 161 74.4 4 27 173 73.S I 23 164 73.4 6 WT. CHG FROM WEEK 0 144 121 156 190 121 152 152 139 162 131 124 120 134 134 123 141 166 170 156 155 138 BFG 002512 REPRODUCTION STUDY 96-4080 C-84 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 4 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2022 2023 2024 2025 2026 2027 2028 2029 2030 WEIGHT G 434 408 340 393 469 345 356 375 389 NO. OF ANIMALS 30 MEANS 384.2 STD. DEV. 32.8 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 37 183 73.4 3 35 162 69.1 0 22 148 75.D -3 32 171 75.6 2 43 204 76.0 6 25 147 73.7 0 4 126 59.3 -25 26 151 69.5 4 26 172 76.2 1 30 30 30 30 26.5 161.5 72.5 0.3 8.5 16.5 3.9 6.5 WT. CHG FROM WEEK 0 179 148 133 151 196 124 125 137 145 30 146.6 21.6 BFG 0025/3 REPRODUCTION STUDY 96-4060 C-85 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 1: 4 OOSE LEVEL - 100.,0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3008 3009 3010 3011 3012 3013 3014 3015 3016 3017 3016 3019 3020 3021 WEIGHT G 369 417 383 387 409 369 401 371 410 329 400 347 370 404 397 414 419 403 386 365 416 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 158 73.8 -11 37 180 75.3 -3 29 155 70.1 1 32 175 78.6 8 32 175 74.2 -8 26 155 72.8 2 21 170 72.6 -3 27 155 72.3 1 31 172 72.7 -3 17 138 71.8 -11 36 168 73.3 -1 13 146 71.5 -8 26 159 74.2 -2 28 169 72.2 -7 36 171 75.2 14 32 172 72.0 -4 31 166 69.4 -22 23 181 77.1 4 35 175 79.1 0 20 158 74.2 2 26 164 67.8 -11 WT. CHG FROM WEEK 0 143 180 143 150 178 148 146 142 169 120 165 104 150 156 153 164 161 144 166 137 174 BFG 002514 REPRODUCTION STUDY 96-4080 C-86 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3022 3023 3024 3025 3026 3027 3028 3029 3030 WEIGHT G 352 371 370 381 328 363 350 390 397 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 21 160 78.1 8 25 169 78.6 11 18 154 71.1 -1 22 165 74.3 -3 12 143 74.0 -10 6 138 63.9 -43 10 150 72.5 -27 25 163 72.0 -8 30 171 74.6 -6 WT. CHG. FROM WEEK 0 129 127 122 139 107 136 122 143 153 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 382.3 25.1 162.6 73.3 -4.7 145.7 STD. DEV. 25.5 8.0 11.7 3.2 11.2 19.5 BFG 002515 REPRODUCTION STUDY 96-4080 C-87 APPENDIX C (cont.) VINYL CHLORIDE COMBINES INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK #: 4 DOSE LEVEL 1100..0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4018 4019 4020 4021 WEIGHT G 370 403 424 386 322 37B 392 375 353 360 400 402 420 366 367 420 395 375 342 396 377 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 31 153 71.9 1 29 168 72.1 0 31 165 67.3 -10 20 1S5 68.3 -3 9 129 67.7 -26 25 164 74.8 -1 22 162 70.9 -9 19 150 68.4 -12 31 140 69.1 -1 27 148 71.2 -5 30 168 72.7 -5 25 172 73.6 -8 36 178 73.8 3 26 160 75.5 4 25 164 77.1 6 33 178 73.5 2 25 161 70.2 -7 30 156 72.2 7 22 153 77.0 2 31 161 70.5 6 37 173 80.4 14 WT. Cl FROM WEEK 142 152 182 134 107 138 136 142 133 147 160 155 184 142 133 157 143 140 134 156 144 BFG 002516 REPRODUCTION STUDY 96-4080 C-88 APPENDIX C (eont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL - 1100 .0000 PPM MALES ANIMAL NO. 4022 4023 4024 4025 4026 4027 402B 4029 4030 WEIGHT G 359 334 329 371 406 3S6 338 345 378 NO. OF ANIMALS 30 MEANS 374.7 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/tCG/OAY G/INT 25 153 73.6 0 32 151 79.1 12 22 143 74.9 -3 26 168 78.2 3 34 184 78.8 0 28 1S5 75.5 8 22 144 73.4 -1 24 140 70.1 -6 24 164 74.7 -24 30 30 30 30 26.7 158.7 73.2 -1.6 WT. CHG. FROM WEEK 0 132 122 112 132 165 116 118 115 139 30 140.4 STD. DEV. 27.8 5.7 12.6 3.5 8.9 18.5 BFG 002517 REPRODUCTION STUDY 96-4080 C-89 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 WEIGHT G 239 217 229 244 182 224 248 231 230 228 233 201 218 232 242 236 234 220 237 211 224 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 26 127 93.7 12 11 106 83.5 1 3 123 90.1 3 16 128 90.8 17 -16 115 100.9 4 13 121 92.7 7 23 125 86.1 7 16 124 92.7 3 14 123 91.9 10 11 119 89.1 4 7 122 88.6 -5 4 103 86.3 -2 12 106 03.3 0 10 127 93.2 8 18 120 85.8 11 6 129 92.3 -1 10 111 80.8 -6 15 107 83.9 -4 16 135 98.3 9 21 123 102.2 22 2 108 80.7 -9 WT. CHG FROM WEEK 0 80 62 69 77 35 59 72 75 75 71 70 48 61 74 72 73 71 65 80 68 59 BFG 002518 REPRODUCTION STUDY 96-4000 C-90 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 4 DOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1522 1523 1S24 1525 1526 1527 1528 1529 1530 WEIGHT G 230 246 219 235 211 205 240 203 216 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 26 121 92.9 13 14 128 88.5 -6 12 111 86.9 -3 14 128 93.6 1 12 110 89.4 -6 9 103 85.6 -3 19 13S 99.0 5 10 103 86.7 -6 16 121 97.0 5 WT. CHG FROM WEEK 0 75 06 68 66 60 S6 70 52 69 NO. OF ANIMALS 30 MEANS 225.6 30 12.4 30 110.8 30 90.3 30 3.0 30 67.5 STD. DEV. 15.3 8.1 9.9 5.6 7.6 10.6 BFG 002519 REPRODUCTION STUDY C-91 96-4080 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL - 10,,0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2508 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 213 230 217 240 222 228 207 207 239 219 222 205 221 213 233 234 218 222 235 222 214 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 111 89.4 -7 22 117 6 105 89.0 81.8 1 -3 7 119 83.9 -6 5 112 85.0 1 11 115 86.1 -6 10 105 86.6 -1 17 103 86.5 1 21 128 93.4 10 19 124 96.6 9 16 121 94.2 10 11 104 86.9 0 14 115 89.6 5 4 110 86.9 -4 27 126 95.7 12 10 114 9 115 83.0 89.8 0 -21 10 124 95.2 -4 14 125 91.4 2 12 116 89.5 1 15 102 82.3 9 WT. CHG. FROM WEEK 0 56 74 57 69 52 70 58 63 70 67 55 53 71 66 73 60 51 66 67 68 61 BFG 002520 REPRODUCTION STUDY 96-4080 C-92 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 OOSE LEVEL - 10..0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2526 2531 2530 WEIGHT G 240 223 220 230 240 210 209 213 215 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/rNT 14 125 69.4 8 -2 107 79.6 -11 6 105 BO.6 -16 26 123 94.5 14 15 130 93.8 -4 16 112 92.4 0 6 111 89.8 -7 7 114 90.7 -1 4 120 93.9 -2 30 30 30 30 WT. CHG FROM WEEK 0 73 46 66 70 75 61 52 73 53 30 MEANS STD. OEV. 222.0 10.7 12.2 6.7 115.3 8.1 89.0 4.9 -0.3 8.0 63.5 7.9 BFG 002521 REPRODUCTION STUDY 96-4080 C-93 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK t: 4 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3508 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 228 218 263 218 218 218 213 225 226 244 201 234 202 203 242 243 190 233 258 233 222 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 10 131 97.9 -2 18 112 89.3 4 20 140 92.2 6 8 113 38.0 0 1 108 82.8 -10 14 126 99.5 3 2 116 91.2 -6 7 123 92.6 2 14 116 89.0 -1 10 123 85.8 -5 8 104 88.0 -10 10 133 96.8 9 12 111 94.4 7 5 117 97.3 2 15 126 89.6 8 12 109 76.7 -9 7 106 96.5 6 18 124 92.3 12 5 130 84.8 -6 27 125 94.9 8 13 126 97.4 7 WT. CHG FROM WEEK 0 81 70 95 52 57 69 60 66 78 82 52 77 58 56 74 78 53 70 87 84 72 BFG 002522 REPRODUCTION STUDY 96-4080 C-94 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TUO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 OOSE LEVEL - 100..0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 352S 3526 3527 3S28 3529 3530 WEIGHT G 217 226 226 233 255 230 250 209 222 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/OAY G/INT 20 118 95.0 9 29 120 94.6 18 11 122 92.2 2 10 130 95.0 -3 8 133 88.3 -9 13 120 89.5 -4 27 154 106.5 7 6 110 89.0 4 9 126 96.6 -1 WT. CHG FROM WEEK 0 73 68 60 76 62 73 93 62 55 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 226.7 17.4 12.3 7.0 121.9 10.7 92.2 5.9 1.6 7.1 70.4 12.1 BFG 002523 REPRODUCTION STUDY 96-4080 C-95 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL - 1100.,0000 PPM FEMALES ANIMAL NO. 4S01 4502 4503 4504 4505 4506 4507 4508 4509 4510 4S11 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 WEIGHT G 240 236 209 234 238 226 227 210 213 232 215 215 207 213 247 229 210 240 220 231 221 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 130 93.2 1 12 125 90.6 2 13 116 95.5 -7 19 116 86.1 -3 7 109 77.5 T 13 115 87.3 11 7 111 82.8 -11 11 111 90.5 -4 23 110 14 120 14 120 91.0 88.9 96.2 10 -4 -2 14 117 93.8 5 16 101 84.6 1 13 106 85.6 -2 11 122 84.2 -9 8 111 82.2 1 4 110 88.1 2 22 136 99.0 29 13 115 89.8 4 21 133 100.5 11 11 118 91.3 -2 WT. Cl FROM WEEK 79 75 61 75 69 53 60 60 62 78 71 52 50 66 77 64 50 77 73 77 69 BFG 002524 REPRODUCTION STUDY 96-4030 C-96 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IH CO RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 4 DOSE LEVEL * 1100.0000 PPM FEMALES ANIMAL NO. 4522 4523 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 235 203 219 225 255 242 226 215 216 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 16 134 98.4 7 6 102 85.0 -4 3 109 83.5 -10 6 133 99.8 -2 17 135 91.3 -2 15 136 96.7 1 14 127 96.7 -1 11 118 93.9 -3 14 117 93.3 -4 WT. CHG FROM WEEK 0 77 S3 61 68 89 84 78 65 65 T * TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 225.0 12.8 118.8 90.6 0.5 67.9 STD. DEV. 13.1 5.0 10.3 5.9 7.9 10.4 BFG 002525 REPRODUCTION STUDY 95-4080 C-97 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 0.0000 PPM MALES ANIMAL NO. 1001 1002 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 WEIGHT G 386 427 393 430 430 382 346 407 437 376 343 443 397 389 384 440 432 381 415 412 405 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 23 156 69.4 5 41 171 70.1 1 29 164 72.2 14 37 167 67.6 10 31 169 68.0 -1 28 158 71.6 8 20 138 68.5 0 26 151 63.9 -7 25 176 69.1 -1 21 145 66.1 3 21 142 71.2 0 27 179 69.5 0 25 158 68.5 16 24 156 69.0 9 29 160 72.2 4 38 183 72.4 6 33 174 69.8 6 24 149 67.3 -1 26 170 70.5 3 32 163 63.6 3 30 162 69.2 5 WT. CHG. FROM WEEK 0 152 177 163 187 196 156 132 172 204 146 132 210 147 159 174 219 187 152 166 178 173 BFG 002526 REPRODUCTION STUDY 96-4030 C-98 APPENDIX C (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 0..0000 PPM MALES ANIMAL NO. 1022 1023 1024 102S 1026 1027 1028 1029 1030 WEIGHT G 406 383 393 409 380 397 406 423 401 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KS/DAY G/INT 32 157 67.1 1 20 141 63.0 -3 22 150 65.4 -1 23 167 70. D -7 24 161 72.9 7 24 157 66.0 1 22 161 67.9 -3 17 153 61.5 -21 20 155 66.1 -3 WT. CHG FROM WEEK 0 186 136 158 179 144 162 IBS 172 146 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 401.8 25.1 26.5 5.8 159.8 11.1 68.6 2.7 1.8 6.9 168.5 22.4 BFG 002527 REPRODUCTION STUDY 96-4080 C-99 appendix c (com.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 10..0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 422 373 430 476 387 410 429 428 453 366 383 375 384 387 357 387 426 455 402 433 406 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 34 174 71.6 9 14 133 60.6 -7 35 166 67.1 8 38 188 68.6 7 32 152 60.3 10 25 160 67.1 8 25 158 63.2 -9 31 172 69.5 10 27 180 68.3 -5 18 150 66.0 -7 21 156 70.7 10 32 157 72.9 7 25 151 67.7 2 30 164 73.5 8 25 156 75.5 10 27 167 74.5 2 30 183 74.2 8 28 190 71.8 4 27 163 69.9 2 27 168 66.7 -5 22 162 68.4 -2 WT. CHG FROM WEEK 0 178 135 191 228 153 177 177 170 209 149 145 152 159 164 146 168 196 206 183 162 160 BFG 002528 REPRODUCTION STUDY 96-4080 C-1QO APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2022 2023 2024 2025 2026 2027 2028 2029 2030 WEIGHT G 463 441 365 420 513 366 398 391 415 S - SPILLAGE WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 29 179 66.5 -4 33 170 66.7 8 25 150 70.9 2 27 179 73.4 8 44 215 73.0 11 21 ISO 70.3 3 42 162 71.6 36 16 152 66.1 1 26 S S S WT. CHG FROM WEEK 0 208 181 158 178 240 145 167 153 171 NO. OF ANIMALS 30 MEANS 412.1 30 27.9 29 165.8 29 69.5 29 4.7 30 174.4 STD. DEV. 36.2 6.8 16.1 3.5 8.5 25.3 BFG 002529 REPRODUCTION STUDY 96-4080 C-101 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 100..0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3008 3009 3010 3011 3012 3013 3014 3015 3016 3017 3018 3019 3020 3021 WEIGHT G 401 446 406 407 437 392 434 400 443 351 42B 369 390 429 407 444 450 441 416 393 445 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 32 175 75.8 17 29 181 69.9 1 23 157 66.3 2 20 165 69.3 -10 28 180 70.9 5 23 155 67.9 0 33 181 72.3 11 29 160 69.2 5 33 175 68.4 3 22 137 67.2 -1 25 180 72.5 12 22 141 65.6 -5 20 162 71.1 3 25 169 67.6 0 10 151 62.6 -20 30 178 69.2 6 31 191 73.3 23 38 195 77.0 14 30 177 73.6 2 28 160 70.4 2 29 172 66.6 8 WT. CHG FROM WEEK 0 175 209 166 170 206 171 179 171 202 142 193 126 170 181 163 194 192 182 196 165 203 BFG 002530 REPRODUCTION STUDY 96-4080 C-102 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 100.0000 PPM MALES ANIMAL NO. 3022 3023 3024 302S 3026 3027 3028 3029 3030 WEIGHT G 373 396 398 402 348 405 377 419 426 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 21 149 66.5 -11 27 167 72.4 -2 28 163 70.7 9 21 163 69.4 -2 20 142 70.0 -1 42 175 76.0 37 27 170 77.9 20 29 166 68.4 3 29 172 69.7 1 WT. CHG. FROM WEEK 0 150 154 150 160 127 178 149 172 182 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 409.2 26.9 167.0 70.3 4.4 172.6 STO. OEV. 28.0 6.1 14.1 3.5 10.8 21.8 BFG 002531 REPRODUCTION STUDY 96-4080 C-103 APPENDIX C fcont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 1100..0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4018 4019 4020 4021 WEIGHT G 397 435 456 421 358 410 425 411 379 366 434 440 453 392 401 450 429 398 379 433 409 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 27 147 63.9 -6 32 169 67.2 1 32 179 67.8 14 33 166 69.2 13 36 156 76.5 27 32 170 71.9 6 33 170 69.4 8 36 156 66.2 6 26 140 63.8 0 26 155 69.3 7 34 181 72.3 13 36 189 74.8 17 33 186 71.8 10 26 161 70.8 1 34 177 76. B 13 30 190 72.8 12 34 173 70.0 12 23 156 67.3 0 37 165 76.3 12 37 174 70.0 13 32 173 73.4 D WT. CHG FROM WEEK 0 169 184 214 167 143 170 169 178 159 173 194 193 217 168 167 187 177 163 171 193 176 BFG 002532 REPRODUCTION STUDY 96-4080 C-104 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT HEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4022 4023 4024 4025 4026 4027 4026 4029 4030 WEIGHT G 365 357 348 405 444 388 369 375 398 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 26 163 73.0 10 23 148 71.4 -3 19 148 72.9 5 34 182 78.2 14 38 194 76.1 10 32 166 74.4 11 31 158 74.5 14 30 146 67.6 6 20 170 73.0 6 30 30 30 30 WT. CHG FROM WEEK 0 158 145 131 166 203 148 149 145 159 30 MEANS STD. DEV. 405.5 30.1 30.8 5.2 167.1 14.3 71.4 3.8 8.4 6.8 171.2 20.7 BFG 002533 REPRODUCTION STUDY 96-4080 C-105 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK f: 5 DOSE LEVEL 0. 0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 WEIGHT G 255 231 250 258 228 234 260 246 247 239 254 216 237 247 263 252 247 233 252 225 249 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 16 129 87.0 2 14 115 85.6 9 21 124 86.3 1 14 131 87.0 3 46 106 86.2 -9 10 110 80.1 -11 12 125 82.0 0 15 116 81.1 -a 17 125 87.4 2 11 119 84.9 0 21 127 86.9 5 17 112 89.1 9 19 114 15 124 83.5 86.3 a -3 21 125 82.5 S 16 126 86.1 -3 13 111 76.9 0 13 110 80.9 3 15 136 92.7 1 14 118 90.2 -5 25 126 88.8 18 UT. CHG FROM WEEK 0 96 76 90 91 81 69 84 90 92 82 91 65 80 89 93 89 84 78 95 82 84 BFG 002534 REPRODUCTION STUDY 96-4080 C-106 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK #: 5 OOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1528 1529 1530 WEIGHT G 234 268 233 245 223 216 262 219 223 NO. OF ANIMALS 30 MEANS 241.6 STD. DEV. 14.7 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 4 108 77.6 -13 20 134 86.6 6 14 118 87.0 7 10 121 84.0 -7 12 110 64.5 0 11 109 86.3 6 22 146 96.9 8 16 109 7 122 86.1 92.6 6 1 30 30 30 30 16.0 120.2 85.8 1.4 7.3 9.6 4.3 6.7 WT. CHG. FROM WEEK 0 79 106 62 76 72 67 100 68 76 30 83.6 10.1 BFG 002535 REPRODUCTION STUDY 96-4080 C-107 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK i: 5 DOSE LEVEL - 10..0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2506 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 226 240 233 262 246 238 225 228 242 242 230 215 243 237 239 248 229 233 235 242 236 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 120 91.1 9 10 116 82.3 -1 16 106 22 126 80.0 83.7 3 7 24 122 10 124 86.9 88.7 10 9 16 110 84.9 5 21 122 93.5 19 3 123 85.2 -5 23 141 102.0 17 6 113 83.3 -8 10 105 83.3 1 22 121 86.9 6 24 120 88.9 10 6 116 81.9 -10 14 114 78.8 0 11 130 96.9 15 11 131 96.0 7 0 123 87.2 -2 20 123 88.4 7 22 116 85.9 14 WT. Cl FROM WEEK 69 84 73 91 76 80 76 64 73 90 63 63 93 90 79 74 72 77 67 88 83 BFG 002536 REPRODUCTION STUDY 96-4080 C-108 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 253 243 221 246 251 219 237 228 231 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 120 20 124 81.1 88.7 -5 17 1 109 82.4 4 16 130 91.0 7 11 128 86.9 -2 9 109 84.7 -3 26 131 97.9 20 15 115 86.9 1 16 124 92.7 4 WT. CHG FROM WEEK 0 86 66 67 86 86 70 80 88 69 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. OEV. 236.6 10.5 14.6 7.2 120.5 8.2 87.6 5.6 5.2 8.0 78.1 9.0 BFG 002537 REPRODUCTION STUDY 96-4080 C-lll APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 5 DOSE LEVEL - 1100,,0000 PPM FEMALES ANIMAL NO. 4501 4502 4503 4504 4505 4506 4507 4508 4509 4510 4511 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 WEIGHT G 253 250 224 226 243 246 236 221 225 239 232 227 221 232 243 245 233 256 241 239 217 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 13 132 89.2 2 14 121 83.0 -4 15 116 89.3 0 -6 102 73.9 -14 5 120 83.2 11 20 112 79.1 -3 9 113 81.4 2 11 110 85.1 -1 12 104 79.1 -6 7 119 84.2 -1 17 128 95.5 8 12 124 93.5 7 14 104 81.0 3 IS 114 85.4 8 -4 110 74.8 -12 16 114 80.2 3 23 117 88.0 7 16 133 89.4 -3 21 129 93.3 14 8 135 95.7 2 -4 89 67.7 -29 WT. Cl FROM WEEK 92 89 76 67 74 73 69 71 74 85 88 64 64 85 73 80 73 93 94 85 65 BFG 002540 REPRODUCTION STUDY 96-4080 C-112 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK f: 5 DOSE LEVEL - 1100..0000 PPM FEMALES ANIMAL NO. 4522 4523 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 264 216 238 248 260 242 232 224 219 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 29 145 96.9 11 13 110 87.5 8 19 130 94.8 21 23 145 102.2 12 5 135 87.4 0 0 137 94.4 1 6 133 96.8 6 9 120 91.1 2 3 116 88.9 -1 WT. CHG FROM WEEK 0 106 66 80 91 94 84 84 74 68 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 236.4 11.4 120.6 87.1 1.8 79.4 STD. DEV. 13.0 8.7 13.2 7.8 9.4 10.9 BFG 002541 REPRODUCTION STUDY 96-4080 C-109 APPENDIX C (cent.) YINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK #: 5 DOSE LEVEL * 100..0000 PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3508 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 251 223 285 241 229 241 225 239 245 259 201 251 212 220 251 240 207 241 277 259 242 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 23 135 93.9 4 5 119 89.9 7 22 145 88.2 5 23 119 86.4 6 11 112 83.5 4 23 130 94.4 4 12 119 90.6 3 14 125 89.8 2 17 116 81.7 -2 15 120 79.5 -3 0 103 85.4 -1 17 134 92.1 1 10 103 82.9 -8 17 120 94.6 3 9 123 83.2 -3 -3 87 60.0 -22 17 109 91.5 1 8 122 85.8 -2 19 135 84.1 5 26 138 20 123 93.5 88.4 13 -3 WT. C! FROM WEEK 104 75 117 75 68 92 72 80 95 97 52 94 68 73 83 75 70 78 106 110 92 BFG 002538 REPRODUCTION STUDY 96-4080 C-110 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK *: 5 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 WEIGHT G 234 241 226 241 262 249 275 235 244 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/DAY G/INT 17 116 85.7 -2 15 122 87.1 2 0 116 85.5 -6 8 120 84.4 -10 7 135 87.0 2 19 129 89.8 9 25 156 99.0 2 26 125 93.8 15 22 133 95.1 7 WT. CHG FROM WEEK 0 90 83 60 84 B9 92 118 88 77 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 241.5 19.4 14.8 7.9 123.0 13.4 87.6 7.0 1.1 7.0 as.2 15.9 BFG 002539 REPRODUCTION STUDY 96-4080 C-113 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 OOSE LEVEL 0..0000 PPM MALES ANIMAL NO. 1001 1002 1003 1004 1005 1006 1007 1006 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 WEIGHT G 414 446 406 456 445 316 367 428 455 363 357 464 410 414 407 466 450 401 430 426 421 WEIGHT FOOD 1CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 28 154 21 158 64.2 60.2 -2 -13 13 147 61.3 -17 26 161 60.6 -6 15 155 59.0 -14 -66 91 21 140 43.5 65.5 -67 2 21 156 62.3 5 18 165 61.7 -11 7 139 14 137 61.0 65.2 -6 -5 21 177 13 149 65.0 61.5 -2 -9 25 153 63.5 -3 23 160 67.4 0 26 180 66.2 -3 IS 169 63.9 -5 20 149 63.5 0 15 169 66.7 -1 14 150 59.7 -13 16 147 59.3 -15 WT. CHG FROM WEEK 0 180 198 176 213 211 90 153 193 222 153 146 231 160 184 197 245 205 172 183 192 189 BFG 002542 REPRODUCTION STUDY 96-4080 C-114 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 OOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1022 1023 1024 1025 1026 1027 1028 1029 1030 WEIGHT G 416 391 410 433 400 408 429 444 419 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 10 146 a 139 60.0 59.9 -9 -2 17 157 65.2 7 24 176 69.7 9 20 161 68.8 0 11 152 62.9 -5 23 158 63.1 -3 21 167 ia 156 64.2 63.4 14 1 WT. CHG FROM WEEK 0 196 144 175 203 164 173 208 193 166 NO. OF ANIMALS 30 3D 30 30 30 30 MEANS 417.1 15.4 154.0 62.6 -5.8 183.8 STD. OEV. 32.7 16.3 16.3 4.6 13.6 30.3 bfg 002543 REPRODUCTION STUDY 96-40S0 C-115 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK I: 6 OOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2006 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 441 400 438 509 402 427 457 450 481 411 395 394 407 399 378 408 448 478 428 448 425 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 19 161 62.2 -13 27 146 63.0 13 8 153 56.8 -13 33 200 67.7 12 15 148 62.5 -4 17 156 62.1 -4 28 172 64.7 14 22 171 28 193 64.9 68.9 -1 13 23 164 68.4 14 12 156 66.8 -2 19 164 71.1 7 23 153 64.5 2 12 158 67.0 6 21 157 71.2 1 21 168 70.4 1 22 177 67.5 6 23 185 66.1 -5 26 168 67.5 5 15 165 62.4 -3 19 158 63.4 -4 WT. Cl FROM WEEK 197 162 199 261 166 194 205 192 237 172 157 171 182 176 169 189 220 229 209 197 179 BFG 002544 REPRODUCTION STUDY 96-4080 C-116 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TW0-6ENERATI0N REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL 10.0000 PPM MALES ANIMAL NO. 2022 2023 2024 2025 2026 2027 2026 2029 2030 WEIGHT G 484 455 390 434 544 377 416 413 435 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 21 181 63.7 2 14 167 62.1 -3 25 166 73.3 16 14 175 68.3 -4 31 221 69.7 6 11 147 65.9 -3 IB 160 65.5 -2 22 156 64.7 4 20 S S S UT. CHG. FROM WEEK 0 229 195 183 192 271 156 185 175 191 S - SPILLAGE NO. OP ANIMALS 30 30 29 29 29 30 MEANS 432.4 20.3 167.1 66.0 1.3 194.7 STD. DEV. 38.8 6.0 16.6 3.4 7.9 28.3 BFG 002545 REPRODUCTION STUDY 96-4060 C--117 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL MALES 100..0000 PPM ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3008 3009 3010 3011 3012 3013 3014 3015 3016 3017 3018 3019 3020 3021 WEIGHT G 421 475 434 432 459 420 431 430 474 370 455 392 414 440 419 429 470 467 443 411 427 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 20 176 71.4 1 29 190 6B.8 9 28 161 63.9 4 25 175 22 165 69.5 68.6 10 5 28 164 67.3 9 -3 165 63.6 -16 30 166 67.5 8 31 179 65.1 4 19 141 65.2 4 27 183 69.1 3 23 155 67.9 14 24 154 63.8 -8 11 157 60.2 -12 12 154 52.1 3 -15 128 46.9 -50 20 169 26 192 68.5 70.5 -2 -3 27 179 69.5 2 18 158 -18 114 65.5 43.6 -2 -58 WT. Cl FROM WEEK 195 238 194 195 228 199 176 201 233 161 220 149 194 192 175 179 212 208 223 183 185 BFG 002546 REPRODUCTION STUDY 96-4080 C-118 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL - 100..0000 PPM MALES ANIMAL NO. 3022 3023 3024 3025 3026 3027 3028 3029 3030 WEIGHT G 385 416 406 421 3S2 424 393 435 438 NO. OF ANIMALS 30 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 12 142 18 166 62.4 66.0 -7 -1 8 156 64.7 -7 19 163 66.0 0 4 130 61.9 -12 19 178 71.6 3 16 158 68.4 -12 16 169 66.0 3 12 156 60.2 -16 30 30 30 30 WT. CHG FROM WEEK 0 162 172 158 179 131 197 165 188 194 30 MEANS STD. DEV. 426.1 29.2 16.9 12.1 162.8 18.9 65.0 6.0 -4.1 15.7 189.5 25.1 BFg 002547 REPRODUCTION STUDY 96-4080 C-119 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #j 6 005E LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4018 4019 4020 4021 WEIGHT G 415 462 484 438 377 430 426 436 402 401 465 458 476 416 420 474 446 414 398 447 414 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 16 152 62.4 5 27 167 62.1 -2 28 175 62.1 -4 17 165 64.0 -3 19 161 73.0 5 20 167 66.3 -3 1 146 57.2 -24 27 161 63.2 5 23 150 64.0 10 15 148 62.7 -7 31 178 66.0 -3 18 184 68.3 -5 23 181 64.9 -7 24 157 64.6 -4 19 171 69.4 -6 24 188 67.8 -2 17 164 62.5 -9 16 155 63.6 -1 19 168 72.1 3 14 168 63.6 -6 5 158 64.0 -15 WT. CHG FROM WEEK 0 187 211 242 184 162 190 170 205 182 188 225 211 240 192 186 211 194 179 190 207 181 BFG 002548 REPRODUCTION STUDY 96-4080 C-120 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL 1100..0000 PPM MALES ANIMAL NO. 4022 4023 4024 4025 4026 4027 4028 4029 4030 WEIGHT G 396 367 366 425 478 402 382 394 423 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/rNT 11 155 66.2 -8 10 139 64.0 -9 18 142 66.3 -6 20 182 73.1 0 34 200 72.3 6 14 150 63.3 -16 13 143 63.5 -15 19 144 62,4 -2 25 180 73.1 10 30 30 30 30 WT. CHG. FROM WEEK 0 169 155 149 186 237 162 162 164 184 30 MEANS STO. DEV. 424.5 33.3 19.0 7.2 163.3 15.4 65.6 3.9 -3.8 7.7 190.2 24.7 BFG 002549 REPRODUCTION STUDY 96-4080 C-121 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL - 0,.0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1516 1517 1518 1519 1520 1521 WEIGHT G 266 239 273 253 229 237 271 248 260 255 262 235 248 255 273 262 258 245 266 236 259 WEIGHT FOOD iCONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 11 116 74.2 -13 8 111 78.7 -4 23 134 85.4 10 -5 123 80.2 -8 1 108 78.8 2 3 111 78.6 1 11 121 76.0 -4 2 114 76.9 -2 13 125 82.2 0 16 115 77.6 -4 8 125 80.7 -2 17 118 86.8 6 11 111 76.3 3 8S S S 10 120 74.6 -5 10 124 80.4 -2 11 114 75.2 3 12 108 75.3 -2 14 134 86.2 -2 11 114 82.4 -4 10 127 83.3 1 WT. CHG FROM WEEK 0 107 84 113 86 82 72 95 92 105 98 99 82 91 97 103 99 95 90 109 93 94 BFG 002550 REPRODUCTION STUOY 96-4080 C-122 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL 0.0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1528 1529 1530 WEIGHT G 248 289 245 246 232 231 240 223 238 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 115 79.5 7 21 140 83.8 6 12 113 78.8 -5 1 121 82.1 0 9 114 83.5 4 15 115 85.8 6 -22 63 41.8 -83 4 112 84.5 3 15 128 92.6 6 WT. CHG. FROM WEEK 0 93 127 94 77 81 82 78 72 91 S - SPILLAGE NO. OF ANIMALS 30 30 29 29 29 30 MEANS 250.7 9.1 117.0 79.4 -3.0 92.7 STO. DEV. 15.5 8.4 13.2 B.4 16.2 12.3 BFG 002551 REPRODUCTION STUDY 96-4060 C-123 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL 10-0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2506 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 239 249 246 277 259 257 233 231 260 246 239 226 252 236 254 263 244 249 255 251 232 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 120 86.0 0 9 123 13 120 15 128 83.3 83.5 79.2 7 12 2 13 126 83.2 4 19 129 86.9 5 6 113 82.2 3 3 111 80.6 -11 18 145 96.3 22 4 130 9 114 88.8 81.0 -11 1 11 113 85.4 8 9 123 82.8 2 -1 109 76.8 -11 15 129 87.2 13 15 125 81.5 11 15 130 91.6 0 16 135 93.4 4 20 130 88.4 7 9 122 4 97 82.5 69.1 -1 -19 WT. CHG FROM WEEK 0 82 93 86 106 89 99 84 87 91 94 72 74 102 89 94 69 87 93 87 97 79 BFG 002552 REPRODUCTION STUDY 96-4080 C--124 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 OOSE LEVEL - 10. 0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 274 261 245 262 261 219 233 244 237 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 21 130 82.2 10 18 125 82.7 1 24 127 90.6 18 16 127 83.3 -3 10 138 69.8 10 0 101 76.9 -B -4 124 67.9 -7 16 127 89.7 12 6 130 92.6 6 vrr. chg FROM WEEK 0 107 84 91 102 96 70 76 104 75 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 247.8 11.2 123.4 84.9 2.9 89.3 STD. DEV. 13.8 7.3 10.3 5.7 9.2 10.1 BFG 002553 REPRODUCTION STUDY 96-4080 C-125 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL - 100..0000 PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3508 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 267 241 298 254 242 247 241 250 258 258 216 265 224 216 256 256 218 237 289 268 241 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT 6/KG/OAY G/INT 16 144 92.7 9 18 121 86.9 2 13 136 77.8 -9 13 131 88.2 12 13 120 84.9 8 6 114 77.9 -16 16 130 93.0 11 11 117 79.6 -8 13 123 81.5 7 -1 115 74.1 -5 15 116 92.7 13 14 135 87.2 1 12 107 81.8 4 -4 na 90.2 -2 5 119 78.2 -4 16 130 87.4 43 11 116 91.0 7 4 113 78.B -9 12 139 B1.9 4 9 131 BZ .9 -7 -1 117 80.7 -6 VTT. Cl FROM WEEK 120 93 130 88 81 98 88 91 108 96 67 10B 80 69 88 91 81 74 118 119 91 BFG 002554 REPRODUCTION STUOY 96*4080 C-1Z6 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 WEIGHT G 236 250 243 253 2B4 253 290 248 263 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 2 110 78.0 -6 9 115 78.1 -7 17 115 81.7 -1 12 128 86.4 8 22 142 86.7 7 4 123 61.7 -6 15 166 97.9 10 13 125 86.3 0 19 144 94.7 11 WT. CHG FROM WEEK 0 92 92 77 96 111 96 133 101 96 NO. OF ANIMALS 30 MEANS 252.1 30 10.5 30 125.3 30 84.7 30 2.4 30 95.6 STD . DEV. 20.7 6.8 12.8 6.0 10.9 16.7 BFG 002555 REPRODUCTION STUDY 96-4080 C-127 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL - 1100..0000 PPM FEMALES ANIMAL NO. 4501 4502 4503 4504 4505 4506 4507 4508 4509 4510 4511 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 WEIGHT G 266 253 231 249 258 251 24B 2 32 232 247 235 235 232 241 271 246 252 251 251 252 242 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 15 142 90.9 10 3 125 82.a 4 7 116 85.0 0 23 121 84.9 19 15 127 64.5 7 5 112 12 124 75.1 85.4 0 11 n 124 92.2 14 7 107 78.0 3 8 112 76.8 -7 3 124 88.5 -4 6 123 88.7 -1 11 112 82.4 8 9 112 78.9 -2 28 139 90.1 29 1 111 75.4 -3 19 122 83.8 5 -5 109 71.7 -24 10 123 83.3 -6 13 131 88.9 -4 25 122 88.6 33 WT. CHG FROM WEEK 0 107 92 83 90 89 78 81 62 81 93 91 72 75 94 101 81 92 88 104 96 90 BFG 002556 REPRODUCTION STUDY 96-4080 C-128 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 6 DOSE LEVEL 1100..0000 PPM FEMALES ANIMAL NO. 4522 4523 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 274 220 252 254 272 264 249 229 234 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 10 140 86.7 -5 4 107 81.6 -3 14 126 87.1 -2 6 133 88.3 -12 12 238 86.5 3 22 146 96.2 9 17 131 90.8 -2 5 118 86.8 -2 15 123 90.5 7 WT. CHG FROM WEEK 0 116 70 94 97 106 106 101 79 83 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. DEV. 247.5 13.8 11.1 7.4 123.4 10.7 85.0 5.6 2.6 11.2 90.5 11.3 BFG 002557 REPRODUCTION STUDY 96-4D60 C-129 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL = 0.0000 PPM MALES ANIMAL NO. 1001 10D2 1003 1004 1005 1006 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1018 1019 1020 1021 WEIGHT G 418 474 427 474 464 390 383 442 479 400 367 492 419 424 417 488 468 414 450 440 438 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 4 144 57,7 -10 26 173 62.5 15 21 148 59.2 1 18 176 63.1 15 19 163 74 157 59.8 74.1 6 66 16 138 61.3 -2 14 147 24 173 56.3 61.7 -9 8 17 122 51.9 -17 10 131 60.3 -6 28 178 9 145 62.1 58.3 1 -4 10 155 61.7 2 10 146 59.1 -14 22 168 58.7 -12 18 165 59.9 -4 13 142 58.1 -7 20 163 61.7 -6 14 155 59.7 5 17 152 59.0 5 WT. CHG FROM WEEK 0 184 224 197 231 230 164 169 207 246 170 156 259 169 194 207 267 223 185 203 206 206 BFG 002558 REPRODUCTION STUDY 96-4060 C-130 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 1: 7 DOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1022 1023 1024 1025 1026 1027 1028 1029 1030 WEIGHT G 436 403 423 462 413 423 442 467 437 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 22 146 57.0 -2 12 137 57.5 -2 13 150 60.0 -7 29 172 64.1 -4 13 158 64.3 -3 15 153 61.4 1 13 149 S7.0 -9 23 164 60.0 -3 18 149 58.0 -7 WT. CHG FROM WEEK 0 218 156 168 232 177 138 221 216 184 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STO. DEV. 435.9 31.6 18.7 12.0 154.0 13.7 60.2 3.7 0.0 14.6 202.6 29.2 BFG 002559 REPRODUCTION STUDY 96-4080 C-131 APPENDIX C (eont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL - 10..0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 WEIGHT G 461 418 465 530 416 443 487 483 493 417 403 412 427 419 399 428 465 498 455 473 450 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 20 168 62.1 7 18 149 60.7 3 27 158 58.3 5 21 184 59.0 -16 14 147 59.9 -1 16 153 58.6 -3 30 168 59.3 -4 33 174 12 179 62.2 61.3 3 -14 6 160 64.4 -4 8 138 57.6 -18 18 145 60.0 -19 20 148 59.2 -5 20 150 61.1 -e 21 152 20 154 65.2 61.4 -5 -14 17 170 20 175 62.1 59.8 -7 -10 27 166 62.7 -2 25 161 25 156 58.3 59.4 -4 -2 WT, CHG FROM WEEK 0 217 180 226 282 182 210 235 225 249 178 165 189 202 196 190 209 237 249 236 222 204 BFG 002560 REPRODUCTION STUDY 96-4060 C-132 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STDOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK t: 7 DOSE LEVEL - 10.0000 PPM MALES ANIMAL NO. 2022 2023 2024 2025 2026 2027 2026 2029 2030 WEIGHT G S06 471 410 463 568 394 433 425 456 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 22 180 60.6 -1 16 160 57.6 -7 20 157 65.4 -9 29 174 64.7 -1 24 210 62.9 -11 17 143 61.6 -4 17 157 61.6 -3 12 149 59.3 -7 23 172 64,2 T WT. CHG FROM WEEK 0 251 211 203 221 295 173 202 187 214 T * TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS STD. DEV. 452.3 41.1 19.9 6.2 161.9 15.1 61.0 2.3 -5.6 6.5 214.7 30.6 BFG 002561 REPRODUCTION STUDY 96-4080 C-133 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK f: 7 DOSE LEVEL 100.,0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 3005 3006 3007 3006 3009 3010 3011 3012 3013 3014 3015 3016 3017 3016 3019 3020 3021 WEIGHT G 441 502 454 462 481 437 437 445 491 386 476 409 439 469 449 457 488 495 466 431 459 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 20 161 62.3 -15 27 178 60.7 -12 20 173 64.9 12 30 177 66.0 2 22 174 17 157 61.7 61.1 -11 -7 6 133 51.1 -32 15 160 61.0 -8 17 178 61.5 -1 16 141 62.2 0 21 177 63.4 -6 17 149 62.0 -6 25 175 68.4 21 29 163 59.8 6 30 160 61.4 6 28 162 60.9 34 18 178 61.9 -11 28 168 65.1 -4 23 184 67.5 5 20 159 62.9 1 32 150 56.4 36 WT. CHG FROM WEEK 0 215 265 214 225 250 216 182 216 250 177 241 166 219 221 205 207 230 236 246 203 217 BFG 002562 REPRODUCTION STUDY 96-4080 C-134 APPENDIX C (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL 100.0000 PPM MALES ANIMAL NO. 3022 3023 3024 3025 3026 3027 3028 3029 3030 WEIGHT G 402 435 429 448 372 443 408 450 459 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 17 136 57.6 -6 19 158 61.9 -8 23 159 63.5 3 27 173 66.4 10 20 144 66.3 14 19 168 64.6 -10 IS 159 66.2 1 15 156 56.6 -13 21 170 63.2 14 WT. CHG FROM WEEK 0 179 191 181 206 151 216 180 203 215 NO. OF ANIMALS 30 MEANS 447.3 30 21.2 30 163.3 30 62.4 30 0.5 30 210.8 STD. DEV. 31.0 5.8 14.0 3.5 14.2 26.7 BFG 002563 REPRODUCTION STUDY 96-4080 C-13S APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPROOUCrrON ANO DEVELOPMENTAL TOXrCITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL - 1100..0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4018 4019 4020 4021 WEIGHT G 429 494 514 469 388 465 463 456 423 418 49S 479 502 441 431 497 469 433 424 477 440 WEIGHT FOOD 'CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 14 147 58.1 -5 32 172 60.0 5 30 166 55.4 -9 31 170 62.5 5 11 145 63.2 -16 35 180 37 131 67.0 67.9 13 35 18 156 58.2 -5 21 144 58.2 -6 17 148 60.2 0 30 181 62.6 3 21 178 63.3 -6 26 174 59.3 -7 25 158 11 154 61.5 60.3 1 -17 23 IBS 63.5 -3 23 169 61.6 5 19 144 26 168 56.7 68.1 -11 0 30 166 59.9 -2 26 164 64.0 6 WT. CHG FROM WEEK 0 201 243 272 215 173 225 207 223 203 205 255 232 266 217 197 234 217 196 216 237 207 BFG 002564 REPRODUCTION STUDY 96-4060 C-136 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4022 4023 4024 4025 4026 4027 4026 4029 4030 WEIGHT G 420 389 362 449 501 427 400 407 446 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 24 154 62.9 -1 22 141 16 143 62.2 63.7 2 1 24 177 67.5 -5 23 192 65.4 -8 25 159 63.9 9 16 145 61.8 2 13 146 60.8 Z 23 182 69.8 2 WT. CHG FROM WEEK 0 193 177 165 210 260 187 180 177 207 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 447.6 23.1 163.0 62.3 -0.3 213.3 STO. OEV. 37.0 6.7 15.1 3.5 9.5 27.8 BFG 002565 REPRODUCTION STUDY 96*4080 C-138 APPENDIX C (cont.) VINYL CHLORIDE COMBINEO INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOO CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 1: DOSE LEVEL o .0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1528 1529 1530 WEIGHT G 255 304 251 260 251 234 251 226 247 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 7 120 79.5 5 15 140 78.7 0 6 114 76.6 1 14 127 83.7 6 19 122 3 106 84.2 77.4 8 -7 11 140 95.0 77 3 102 75.7 -10 9 123 84.5 -5 WT. CHG. FROM WEEK 0 100 142 100 91 100 65 89 75 100 T TECHNICAL PROBLEM NO. OF ANIMALS 30 30 30 30 29 30 MEANS 25B.5 7.B 118.5 77.6 1.1 100.5 STD. DEV. 15.8 6.3 10.7 5.9 16.3 12.6 BFG 002566 REPRODUCTION STUDY 96-4080 C-137 APPENDIX C fcont.J VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT ANO POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL 0.0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1508 1509 1510 1511 1512 1513 1514 1515 1S16 1517 1518 1519 1520 1521 WEIGHT G 266 256 273 272 241 246 275 267 272 266 274 237 248 267 273 265 260 252 264 237 264 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 2 124 77.4 8 17 115 77.4 4 0 127 77.5 -7 19 128 81.3 5 12 109 77.3 1 9 117 4 UB 80.7 72.0 6 -3 19 119 77.0 S 12 131 82.1 6 11 125 80.0 10 12 119 74.0 -6 2 105 74.2 -13 0 103 69.2 -8 12 129 82.4 T 0 114 69.6 -6 3 105 66.4 -19 2 108 69.5 -6 7 106 -2 134 71.1 84.3 -2 0 1 108 76.1 -6 5 115 73.3 -12 WT. CHG. FROM WEEK 0 109 101 113 105 94 81 99 111 117 109 111 84 91 109 103 102 97 97 107 94 99 BFG 002567 REPRODUCTION STUDY 96-4080 C-139 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2508 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 243 253 250 279 260 261 236 237 268 253 23? 233 266 258 264 268 245 266 269 259 232 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 4 115 79.5 -5 4 111 73.7 -12 4 105 70.6 -15 2 111 66.5 -17 1 111 71.3 -15 4 118 75.9 -11 3 100 71.1 -13 6 106 76.9 -3 8 132 83.3 -13 7 128 -2 IDA 85. S 72.8 -2 -10 7 105 76.3 -8 14 112 72.1 -11 22 119 80.3 10 10 123 79.2 -6 5 113 70.9 -12 1 125 85.2 -5 17 129 33.5 -6 14 129 82.1 -1 8 113 73.9 -9 0 69 63.9 -8 WT. CHG FROM WEEK 0 86 97 90 108 90 103 87 93 99 101 70 81 116 111 104 94 88 110 101 105 79 BFG 002568 REPRODUCTION STUDY 96-4080 C-140 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CO RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK I: 7 DOSE LEVEL 10..0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 279 265 246 245 270 232 244 249 235 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 5 118 71.1 -12 4 118 74.8 -7 1 106 72.0 -21 -17 110 72.3 -17 9 131 82.2 -7 13 112 82.8 11 11 117 81.8 -7 5 119 80.5 -6 -2 116 81.9 -14 30 30 30 30 wr. CHG FROM WEEK 0 112 88 92 85 105 83 87 109 73 30 MEANS STD. DEV. 253.4 14.3 5.6 114.9 7.0 9.8 76.5 5.7 -8.5 7.0 94.9 12.0 BFG 002569 REPRODUCTION STUDY 96-4080 C-141 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 7 DOSE LEVEL 100.0000 PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3508 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 281 252 300 259 250 249 244 260 265 273 228 272 229 247 262 269 223 250 301 281 256 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL G G/INT G/KG/DAY 14 137 83.3 11 117 79.1 2 130 72.5 5 118 76.7 8 116 78.6 2 109 73.3 3 121 83.2 10 125 81.7 7 107 68.2 15 113 70.9 12 117 87.8 7 123 76.4 5 104 76.5 31 113 6 102 81.4 65.6 13 118 74.9 5 104 78.6 13 120 82.1 12 127 71.8 13 127 77.1 15 113 75-6 CHANGE G/INT -7 -4 -6 -13 -4 -5 -9 8 -16 -2 1 -12 -3 -5 -17 -12 -12 7 -12 -4 .4 WT. ( FROf WEEK 134 104 132 93 89 100 91 101 115 111 79 115 85 100 94 104 86 87 130 132 106 BFG 002570 REPRODUCTION STUOY 96-4080 C-142 APPENDIX C (contO VINYL CHLORIDE COMBINE!) INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK *: 7 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 WEIGHT G 245 239 242 254 294 261 297 248 257 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT GyKG/DAY G/INT 9 113 78.3 3 -11 98 66.8 -17 -1 106 72.9 -9 1 116 76.3 -12 10 133 76.7 -9 e 119 77.2 -4 7 143 81.2 -23 0 111 74.6 -14 -6 119 76.3 -25 WT. CHG FROM WEEK 0 101 81 76 97 121 104 140 101 90 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 259.6 7.5 117.3 76.5 -8.0 103.3 STD. DEV. 20.7 7.6 10.4 5.0 7.7 17.5 BFG 002571 REPRODUCTION STUDY 96-4080 C-143 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 1: 7 DOSE LEVEL - 1100..0000 PPM FEMALES ANIMAL NO. 4501 4502 4503 4504 4505 4506 4507 4508 4509 4510 4511 4512 4513 4514 4515 4516 4517 4518 4519 4520 4521 WEIGHT G 267 269 229 257 260 263 256 243 233 258 248 237 231 244 277 247 259 247 257 262 250 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/JCG/DAY G/INT -1 124 77.3 -18 16 126 80.5 1 -2 104 75.4 -12 8 102 67.2 -19 2 119 76.6 -8 12 108 70.0 -4 6 109 72.1 -15 11 116 81.4 -8 1 104 74.6 -3 11 12S 82.5 13 13 120 82.8 -4 2 119 84.0 -4 -1 97 69.8 -15 3 105 72.2 -7 6 127 77.3 -12 1 96 64.9 -15 7 117 76.3 -5 -4 101 67.6 -8 6 113 74.1 -10 10 131 85.0 0 e 118 79.9 -4 WT. Cl FROM WEEK 106 108 81 98 91 90 89 93 82 104 104 74 74 97 107 82 99 64 110 108 98 BFG 002572 REPRODUCTION STUDY 96-4060 C-144 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK f: 7 DOSE LEVEL - 1100.,0000 PPM FEMALES ANIMAL NO. 4522 4523 4524 4525 4526 4527 4528 4529 4530 WEIGHT G 271 223 259 266 280 264 252 242 243 NO. OF ANIMALS 30 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT -3 126 77.1 -14 3 101 76.0 -6 7 124 80.9 -4 12 137 87.8 4 8 131 79.1 -7 0 131 82.7 -15 3 126 83.8 -5 13 123 87.0 5 9 120 83.9 -3 30 30 30 30 WT. CHG FROM WEEK 113 73 101 109 0 114 106 104 92 92 30 MEANS STD. DEV. 253.1 14.2 5.6 116.7 5.4 11.4 77.7 6.1 -6.7 7.2 96.1 12.1 BFG 002573 REPRODUCTION STUDY 96-4060 C-145 APPENOIX C (cent.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #; 6 DOSE LEVEL - 0. 0000 PPM MALES ANIMAL NO. 1001 1002 1003 1004 1005 1005 1007 1008 1009 1010 1011 1012 1013 1014 1015 1016 1017 1010 1019 1020 1021 WEIGHT G 437 475 449 462 492 397 398 453 406 403 301 505 437 436 433 508 489 432 446 451 457 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 19 156 60.6 12 l 147 51.6 -26 22 162 61.6 14 -12 128 45.6 -48 28 168 58.6 5 7 134 56.8 -23 15 142 n 146 60.6 54.4 4 -1 7 165 57.0 -8 3 136 56.5 14 14 136 60.6 5 13 171 57.2 -7 18 151 58.8 6 12 150 58.1 -5 16 144 56.5 -2 20 183 61.2 15 21 167 58.2 2 18 138 54.4 -4 -4 157 58.4 -6 11 143 53.5 -12 19 161 60.0 9 WT. CHG FROM WEEK 203 225 219 219 258 171 184 218 253 173 170 272 187 206 223 287 244 203 199 217 225 BFG 002574 REPRODUCTION STUDY 96-4080 C-146 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION 8 DOSE LEVEL 0.0000 PPM MALES ANIMAL NO. 1022 1023 1024 1025 1026 1027 1028 1029 1030 WEIGHT G 459 407 441 478 413 424 452 469 453 NO. OF ANIMALS 30 WEIGHT FOOO CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 21 153 56.9 7 4 135 55.6 -2 18 153 59.0 3 16 164 58.2 -8 0 151 60.9 -7 1 137 53.9 -16 10 155 57.8 6 2 163 16 154 58.0 57.7 -1 5 30 30 30 30 WT. CHG. FROM WEEK 0 239 160 206 248 177 189 231 218 200 30 MEANS STD. DEV. 447.4 32.4 11.6 9.0 151.7 13.0 57.3 3.3 -2.3 13.3 214.1 31.3 BFG 002575 REPRODUCTION STUDY 96-4080 C-147 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY HEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 8 DOSE LEVEL - 10.,0000 PPM MALES ANIMAL NO. 2001 2002 2003 2004 2005 2006 2007 2006 2009 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2020 2021 HEIGHT G 479 437 485 547 430 456 496 504 481 423 413 428 442 429 414 447 480 521 467 486 461 WEIGHT FOOD iCONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT IB 171 60.6 3 19 151 58.9 2 20 156 54.7 -2 17 177 54.8 -7 14 147 57.9 0 13 149 55.2 -4 9 158 53.6 -10 21 177 59.8 3 -12 141 48.3 -38 6 147 58.3 -13 10 148 16 148 60.5 58.7 10 3 15 151 57.9 3 10 149 58.6 -1 15 147 60.3 -5 19 160 61.0 6 15 161 56.8 -9 23 179 58.6 4 12 157 56.8 -9 13 161 56.0 0 11 158 57.8 2 HT. Ct FROM WEEK 235 199 246 299 196 223 244 246 237 184 175 205 217 206 205 228 252 272 248 235 215 BFG 002576 REPRODUCTION STUDY 96-4080 C-148 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 8 DOSE LEVEL - ID..0000 PPM MALES ANIMAL NO. 2022 2023 2024 202S 2026 2027 2028 2029 2030 WEIGHT G 529 483 424 473 581 403 447 435 475 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 23 180 58.0 0 12 156 54.5 -4 14 162 64.7 5 10 176 62.7 2 13 194 56.3 -16 9 142 59.4 -1 14 159 60.2 2 10 147 17 185 57.0 66.1 -2 13 WT. CHG FROM WEEK 0 274 223 217 231 308 182 216 197 231 NO. OF ANIMALS 3D 30 30 30 30 30 MEANS STD. DEV. 465.9 42.1 13.5 6.4 159.8 13.9 58.1 3.4 -2.1 9.3 228.2 31.8 BFG 002577 REPRODUCTION STUDY 96-4080 C-149 APPEN0IX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT ANO FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 9: 8 DOSE LEVEL - 100..0000 PPM MALES ANIMAL NO. 3001 3002 3003 3004 300S 3006 3007 3008 3009 3010 3011 3012 3013 3014 3015 3016 3017 3018 3019 3020 3021 WEIGHT G 459 516 466 474 510 454 464 470 505 398 472 427 451 480 464 474 503 502 487 418 483 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 18 171 63.3 10 14 178 58.3 0 12 159 57.6 -14 12 169 60.2 -8 29 179 60.2 5 17 155 58.0 -2 27 163 60.3 30 25 163 59.4 3 14 175 58.6 -3 12 139 59.1 -2 -4 157 55.2 -20 18 149 59.4 0 12 156 58.4 -19 11 157 55.1 -6 15 158 57.7 -2 17 159 56.9 -3 15 170 57.2 -8 7 182 60.8 6 21 175 61.2 -9 -13 139 54.6 -20 24 167 59.1 17 WT. Cl FROM WEEK 233 279 226 237 279 233 209 241 264 189 237 184 231 232 220 224 245 243 267 190 241 BFG 002578 REPRODUCTION STUDY 96-4080 C-150 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOY WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION CD -o Q WEEK #: DOSE LEVEL 0000 PPM MALES ANIMAL NO. 3022 3023 3024 3025 3026 3027 3026 3029 3030 WEIGHT G 417 446 424 459 384 452 423 463 478 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT IS 146 59.4 10 11 160 60.5 2 -5 154 60.2 -5 11 159 58.4 -14 12 148 65.3 4 9 163 60.7 -5 15 1S9 63.8 0 13 157 57.3 1 19 159 56.6 -11 WT. CHG. FROM WEEK 0 194 2Q2 176 217 163 225 195 216 234 NO. OF ANIMALS 30 30 30 30 30 30 MEANS STD. OEV. 460.8 32.9 13.4 8.8 160.8 10.9 59.1 2.4 -2.5 10.7 224.2 28.9 BFG 002579 REPRODUCTION STUDY 96-4000 C-1S1 APPENDIX C (cont.) YINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION ANO DEVELOPMENTAL TOXICITY STUDY IN CO RATS WEEK #: INDIVIDUAL BODY HEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION a DOSE LEVEL * 1100..0000 PPM MALES ANIMAL NO. 4001 4002 4003 4004 4005 4006 4007 4008 4009 4010 4011 4012 4013 4014 4015 4016 4017 4010 4019 4020 4021 WEIGHT G 448 507 527 490 416 483 475 477 449 436 524 494 510 458 435 502 463 446 442 493 459 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 19 150 57.0 3 13 171 56.9 -1 13 155 49.6 -11 21 166 57.7 -4 28 152 63.0 7 IS 171 60.1 -9 12 165 56.6 -16 21 164 58.6 8 26 141 53.9 -3 18 151 58.9 3 29 176 57.6 -5 15 175 60.0 -3 16 165 53.9 9 17 160 59.3 2 4 147 56.6 -7 5 176 58.7 -9 14 159 55.7 -10 13 146 55.4 2 IB 164 63.1 -4 16 166 57.0 0 19 166 61.5 2 WT. CHG FROM WEEK 0 220 256 285 236 201 243 219 244 229 223 284 247 282 234 201 239 231 211 234 253 226 BFG 0025S0 REPRODUCTION STUDY 96-4080 C-152 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOO - PI GENERATION WEEK H 8 OOSE LEVEL - 1100.0000 PPM MALES ANIMAL NO. 4022 4023 4024 4025 4026 4027 4028 4029 4030 WEIGHT G 428 403 392 454 515 443 420 421 466 NO. OF ANIMALS 30 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT B 147 57.8 -7 14 140 58.9 -1 10 140 60.3 -3 5 166 14 177 61.3 58.1 -11 -15 16 157 60.2 -2 20 151 61.4 6 14 141 56.8 -5 20 176 64.3 -6 30 30 30 30 WT. CHG FROM WEEK 0 201 191 175 215 274 203 200 191 227 30 MEANS STD. DEV. 463.S 37.0 15.9 6.1 159.4 12.0 58.4 3.0 -3.6 6.2 229.2 28.6 BFG 002581 REPRODUCTION STUDY 96-4060 C-153 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: a OOSE LEVEL - 0..0000 PPM FEMALES ANIMAL NO. 1501 1502 1503 1504 1505 1506 1507 1506 1509 1510 1511 1512 1513 1514 1515 1516 1517 1516 1519 1520 1521 WEIGHT G 281 255 263 275 257 251 283 272 281 270 277 272 244 262 283 275 266 259 280 247 262 WEIGHT FOOD iCONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 122 74.1 -2 -1 107 69.8 -8 -10 121 75.2 -6 3 135 82.3 7 16 115 77.0 6 5 116 77.8 -1 B 122 72.9 4 5 124 76.7 5 9 132 79.6 1 4 117 72.8 -a 3 122 73.8 3 35 135 88.4 30 -4 102 69.1 -1 15 129 78.3 0 10 119 71.3 5 10 131 80.9 26 6 99 62.7 -9 7 99 64.6 -7 16 135 82.7 1 10 113 77.8 5 -2 107 67.8 -8 WT. CHG. FROM WEEK 0 122 100 103 108 110 86 107 116 126 113 114 119 87 124 113 112 103 104 123 104 97 BFG 002582 REPRODUCTION STUDY 96-4080 C-154 APPENOIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BOOT WEIGHT AND POOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK 1: 8 DOSE LEVEL - 0. 0000 PPM FEMALES ANIMAL NO. 1522 1523 1524 1525 1526 1527 1528 1529 1530 WEIGHT G 268 304 246 268 257 236 245 232 252 WEIGHT POOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 114 72.7 -6 0 119 65.2 -21 -5 101 67.7 -13 8 123 77.7 -4 6 120 78.7 -2 2 107 75.9 -1 6 115 77.3 -25 6 106 77.1 4 5 118 78.8 -5 WT. CHG PROM WEEK 0 113 142 95 99 106 87 83 81 105 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 264.8 6.2 117.5 74.9 -1.0 106.7 STD. DEV. 16.4 8.5 10.7 5.8 10.9 14.0 BFG 002583 REPRODUCTION STUDY 96-4080 C-155 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 8 DOSE LEVEL - 10.0000 PPM FEMALES ANIMAL NO. 2501 2502 2503 2504 2505 2506 2507 2506 2509 2510 2511 2512 2513 2514 2515 2516 2517 2518 2519 2520 2521 WEIGHT G 251 250 270 276 261 286 248 240 279 260 245 240 262 266 271 272 252 264 265 262 236 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/1NT G/KG/OAY G/INT 8 106 -3 108 71.5 71.6 -9 -3 20 120 76.9 15 -3 108 64.9 -3 1 113 25 132 72.3 80.4 2 14 12 101 69.6 1 3 10S 73.4 -3 11 132 80.4 0 7 124 80.6 -4 8 108 74.7 4 7 108 -4 106 76.1 66.9 3 -6 8 115 7 123 73.2 76.6 -4 0 4 116 71.6 3 7 117 78.5 -8 -2 110 -4 115 3 110 69.2 71.8 70.4 -19 -14 -3 4 95 67.7 6 WT. CHG FROM WEEK 0 94 94 110 105 91 128 99 96 110 108 78 86 112 119 111 98 95 108 97 108 S3 BFG 002584 REPRODUCTION STUDY 96-4080 C-156 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUOY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 8 DOSE LEVEL - 10. 0000 PPM FEMALES ANIMAL NO. 2522 2523 2524 2525 2526 2527 2528 2531 2530 WEIGHT G 285 265 251 262 279 245 249 254 238 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 6 117 69.1 -1 0 117 73.6 -1 5 110 73.8 4 17 127 83.5 17 9 138 83.8 7 13 113 79.0 1 5 114 77.1 -3 5 121 80.2 2 3 100 70.5 -16 WT. CHG. FROM WEEK 0 118 88 97 102 114 96 92 114 76 NO. OF ANIMALS 30 30 30 30 30 30 MEANS 259.5 6.1 114.3 74.3 -0.6 101.0 STD. DEV. 14.0 6.8 9.9 5.0 8.1 12.4 BFG 002585 REPRODUCTION STUDY 96-4080 C-1S7 APPENDIX C (cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREMATING TREATMENT PERIOD - PI GENERATION WEEK #: 8 DOSE LEVEL 100..QQQQ PPM FEMALES ANIMAL NO. 3501 3502 3503 3504 3505 3506 3507 3508 3509 3510 3511 3512 3513 3514 3515 3516 3517 3518 3519 3520 3521 WEIGHT G 282 254 306 256 252 260 260 265 272 269 225 266 235 265 274 261 233 238 306 286 257 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/OAY G/INT 1 138 81.7 1 2 113 74.4 -4 8 125 68.5 -5 -3 110 71.2 -8 2 108 71.7 -8 11 114 74.7 5 16 125 82.7 4 5 115 73.0 -10 7 108 67.0 1 -4 105 64.6 -8 -3 104 76.5 -13 -6 122 75.6 -1 6 115 82.6 11 18 129 84.0 16 12 112 69.7 ID 12 118 71.5 0 10 no 80.4 6 -12 105 71.7 -15 5 138 75.8 11 5 122 71.7 -5 1 109 70.8 -4 WT. Cl FROM WEEK 135 106 140 90 91 111 107 106 122 107 76 109 91 118 106 116 96 75 135 137 107 BFG 002586 REPRODUCTION STUDY 96-4080 C-158 APPENDIX C {cont.) VINYL CHLORIDE COMBINED INHALATION TWO-GENERATION REPRODUCTION AND DEVELOPMENTAL TOXICITY STUDY IN CD RATS WEEK #: INDIVIDUAL BODY WEIGHT AND FOOD CONSUMPTION PREHATING TREATMENT PERIOD - PI GENERATION 8 DOSE LEVEL - 100.0000 PPM FEMALES ANIMAL NO. 3522 3523 3524 3525 3526 3527 3528 3529 3530 WEIGHT G 258 250 254 268 293 275 313 252 255 NO. OF ANIMALS 30 MEANS 265.4 STD. DEV. 21.4 WEIGHT FOOD CONSUMPTION CHANGE ACTUAL CHANGE G G/INT G/KG/DAY G/INT 13 118 78.2 5 11 104 70.9 6 12 115 77.3 9 14 127 81.1 11 -1 130 73.8 -3 14 128 79.6 9 16 154 84.2 11 4 111 74.0 0 -2 125 81.4 6 30 30 30 30 5.8 118.6 75.3 1.3 7.5 11.7 5.3 8.1 WT. CHG. FROM WEEK 0 114 92 88 111 120 118 156 105 88 30 109.1 19.0 BFG 002587