Document a451NvMn4yLK0pGVGyEVvQoOb

June 15, 1945 PERSONAL ANT CONFIDENTIAL Mr. S 0. Jone3, Ethyl Corporation, Chrysler Building, Hew York City. Dear Mr. Jones? I am sending you herewith three copies of a memorandum giving the information which I obtained at the time of my trip to the lake Erie Chemical Company in Cleveland, together with my recommendations. It seems probable that other persons in the ITew York Office will wi3h to see this memorandum, especially Mr. Schaefer of the Manufacturing Department, and probably Mr. Gonzalez. In any case I am sending all of the copies to you because of the confidential character of some of the information This should be dealt with as similar matters of military conse quence are handled. I dare say it will be necessary to inform Dr. Edelman as to whether he can purchase the tetraethyl lead in liter cans. If it is decided that this can be done,he should be so informed and then instructed to place an order for the necessary materials Ample space is available for the storage of the entire quantity of tetraethyl lead referred to in the memorandum. I believe this covers the subject, but if there are any further questions, I shall do my best to answer them. Very truly yours. EAK ef Enc. itobert A ." jJehoe , M D KE 001 4 6 June 15, 19k? Dr-. L. E. Edelman, Director of Research, Lake Erie Chemical Company, 2200 Scranton Road, Cleveland, Ohio. Dear Dr. Edelman.* In accordance with our conversation of last Thursday, I am sending you by express a- package containing six bottles for the collection of samples of urine from three of you who will be concerned in the work which we discussed . I am sending you herewith instructions for the collection of the samples. Please use every possible precaution to prevent the contamina tion of these samples. Since we are dealing with micro quantities of both lead and arsenic, you will realize the necessity for these precautions. I should be glad if you would collect approximately 100 ml of urine in each container. Each of you can obtain such a sample on two different occasions. If you wish to do it,both samples can be collected on the 3ame day, but I want two samples from each man in order to check the variability. e shall do lead and arsenic determinations on each sample. I have put through my recommendations with reference to the manner in which tetraethyl lead should be sent to you. it may not be possible to follow my recommendations, but in any case you will hear from the New York Office and will receive instructions on how to put in your order- "When you have re ceived your stock and have actually got your work under way, please let me know for I shall want to send you additional con tainers for samples of urine at intervals of about ten days. Moreover, if it happens that tlie lead has to be sent to you in a drum, I shall want to send you some additional instructions. I shall be informed on that subject as soon as you will.I I am sending you herewith a set of Instructions for handling tetraethyl lead in your laboratory. You will probably receive additional instructions from the Manufacturing Department, with reference to the manner of cleaning and returning the liter cans. If there is any other information which you re quire, do not hesitate to let me know. I have written to find out one or two things about the thermal decomposition of tetra ethyl lead, and I am passing this information along to you when I receive it. This is in answer to your question which K*r 0013740 N16576.01 Dr. L. E. Edelman - (2) - June 15* 19^5 I was unable to answer directly. "Very truly yours. BAK ef Enc. 'HoberfA. gSSoerM.'B1:1 KE 0013750 r W^Y ' COISFBSSJKriAL Memoranchaa cn yo of Tetraethyl Lead by the Lake Erie Chemical Company Reference 13 made to Hr- Jones1 letter of May la, 19^2 to Mr. Saley, concerning his (Jones) visit to Cleveland to visit the subject Company, On M.y 12, in Xiao with the atatoment in Mr. Jones* letter, a letter was received fraa X>r. L. L. Telman, Director of Research of Lake Erie Chemical Company, explaining briefly their need for tetraethyl lead in connection with the mnufactur of an n^ent for the Chemical *' rfare '"ervlce. It was 'decided that a trip to the slant was necessary to determine a nustiber of pertinent facto, and on tunc lo, such a visit wa3 made. The present plan of Like Erie Cheaaical Company la to mike ?enroximtoly pounds of ethyl arsenioua dichloride (CgHpAeCi;* / over a period of about pO days at the rate of about Ip pounds per day. It I3 proposed that this b don by reacting tetraethyl lead with arsenic trichloride on a laboratory scale* The lead compound, diluted with carbon tetrachloride and cooled, is treated with arsenic tri chloride a little at a time, the contents of the flask being cooled continuously in order to control the reaction. Preliminary experl- mats have indicated that this procedure is satisfactory and that the load compound is completely used up in the presence of an excess of the arsenic trichloride. The latter will bo tested further to esta blish the fact with certainty. It may be that greater quantities of the material will ha ve to be made Inter, but that eventuality la not under present considera tion. The manufacturing operation will be carried out in a laboratory KB 0013751 N 16576.02 a that appears to bo adequate far the purpose# by trained personnel vho appear* to bo wholly competent. All the work, including that of cloaning up glassware and the laboratory hood in which the work is to be carried out, will bo done bp from two to three on, all of whom are trained chemists. Sach batch will probably consist of one liter of tetraethyl lead, the diluent carbon tetrachloride, and arsenic trichloride in slight excess. It is proposed to use a round, 5 L. pyrex flash with three connections (one to a cropping funnel, on to a condenser, and one to a thermometer}, the whole surrounded by a notal '.ontainer for the cooling bath sufficient in sir.. to hold the entire contents of the pyrex flask {If It should break'* fhe equip ment is sot up in & chemical hood with adequate ventilation. Tho facilities of the laboratory. In which other very fnngercu3 chemicals lave been handled^include an emergency'shower of an effective typo, adequate canister masks# protective aprons and rubber gloves of goed quality. There is also in an adjoining room, veil ventilated storage cabinet that can he kept locked This is ample for the storage of the quantities of tetraethyl lead required . at this tins. The request was made for instructions for cleaning glassware and other apparatus for advice in preventing spillage and other acci dent that might cause exposure* 2very evidence van given of willing ness n.rd ability to follow instructions * For these reasons it Is believed that there will be little or no trouble in connection with this work. Instructions will be pro vided in the usual manor* Uso it was agreed that the extent of the control of the exposure could easily be checked by periodic analyses of samples of urine from the men. Arrangements have been made to make K 0013 *b Z In order to facilitate safety in this vork, ana to help in the avoidance of unnecessary handling of tetraethyl lead, it is rcommended that the latter he provided in liter cans# these to he pre served and returned to the Manufacturing department of the Ethyl Cor poration . Instructions for cleaning end returning the cans should he given by the Manufacturing tep&rtiaeat. If the tetraethyl lead can he supplied in this mnner, it is believed that there vill be no need for adding dy to it for purposes of further safety On the basis of the catIanto given of material needed, approximately fO liters of totraothyi toad vill be required. It is recognised that'this my be trot*-. blesoiso for the Manufacturing Department, and that cans are at a pre mium. Mevertheless it is believed that this Is justified if It is at -.11 feasible to do it, sine the dangers of vortklng with tetraethyl lead under the existing conditions :1a this laboratory vill thereby bo largely eliminated. 3y this means the cun of tetraethyl lord eon b> used as the unit for the reaction, the can being then rinsed cut and set aside for return. Since the lead vill be need up entirely in the reaction there is no reason for supposing that contact vlih or exposure to tetraethyl lead vill occur at any time, With the ordinary bare to avoid accidents and to control the reaction, there should bo no trouble whatever in carrying out this- work. The handling of tetraethyl load in a drum or drums, on th other hand, vill he an exceedingly trouble some laboratory operation, requiring special apparatus end precautions. June i:3, Xfkjj KE 00 J 3753 ledleal Iircctor