Document a1mQNg0xkgX1879G6MJ8KmRQa
TOXICOLOOV ENVIRONMENTAL C IEN C E* C M tM IV TA r PLANT ftCIENCCS MEDICAL SC IEN C ES
DnDu^tAioi BIO-TEST
1810 F R O N T A G E RO A D NORTHBROOK. ILLINOIS 60062
M ay 19, 1976
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AA*A C O O t 1* TCLCPHONC * 7 1 - 3 0 3 0
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D r. M orris W einberger D irecto r, Division of Pathology B ureau of F oods, Room 5058 Food and Drug A dm inistration 200 "C" S treet, S.W . W ashington, D. C. 20204
D ear D r. W einberger:
P e r D r. K olbye's le tte r dated M arch 22, 1976, and your telephone in q u iry of M ay 17; we a r e fo rw ard in g the liv e r slid e s fro m a ll, except two dogs, of our tw o -y ear o ra l feeding study (IBT No. C7299) for your review .
The box consists of a total of seventy-six slides. The anim al and slide identification inform ation is on the attached sheet and also a p p ears on the slid e s. The slides a re filed in the sam e sequence as the anim als a re listed . The le tte rs "A ", "B ", and "C ", on the list and slides re fe r to A roclor 1242, 1254, and 1260, respectively. The control anim als fo r a ll th ree te st m a te ria ls w ere shared (common controls). The m issing slid es fro m the two anim als (Male No. 28, G roup T-IIIC ; F em ale No. 31, Group T-IIIB) w ill follow as soon as we locate them .
Sincerely yours
Donovan E. Gordon, D. V . M . , Ph. D Section Head, Pathology
D EG /ji
cc: M. L. Keplinger D r. G eorge R oush, J r . - M onsanto'" P roject C enter
708076
tidM i BIO-TEST M ioti*, Sm.
G ro u p
U ntreated Control
It II II It M II
A ro c lo r 1242 (A) T -I
II II II
T-H
It II tl II
T-m
ii ii it it
U ntreated Control
ii
T -I
II
T-n
T -III
II
U ntreated C ontrol
ii
T -I
ii
T-n
n
T-m
L iv er Slides for C7299 (M onsanto)
Dog No. & Sex
D isposition
1M 2M 5F 7F
2-year sacrifice
II
II II
9M 12 M 13 F 16 F
17 M 18 M 19 M 21 F 24 F
25 M 26 M 29 F 30 F 31 F
3M 6M
11 M 14 F
22 F
28 M 32 F
4M 8F
10 M 15 F
20 M 23 F
27 M
2-year sacrifice
h
D ied T e s t W eek - 82 2 -year sacrifice
II tl II
2 -year sacrifice
II II
Sacrificed in ex trem is te st wk.
Il
30-day recovery sacrifice
h
m h
h
h
il
60-day recovery sacrifice
h
h m
h
h
h
HEV 008323
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Sttduihid BIO-TEST Xal toum, 9m
G roup_____
A ro c lo r 1254 (B) T -I
it m II
T -Il ti n n it
T-IU
ii ii
II II
T -I
ii
T -II
ii
T-m
T -I
II
T -II
T -III
ii
A ro c lo r 1260 (C) T -I
It It II
T -II
tt it n
T-III
L iv er Slides for C7299 (M onsanto)
Dog No. ft Sex
D isposition
9M 10 M 15 F 16 F
19 M 20 M 22 F 23 F 24 F
26 M 27 M 29 F 30 F 31 F (slide m issin g )
11 M 14 F
17 M 21 F
25 M
12 M 13 F
18 M
28 M 32 F
2-year sacrifice ii
it H
m
D ied te s t w eek - 37 2-year sacrifice
2-year sacrifice " "
D ied t e s t w eek - 33
30-day recovery sacrifice
ii
II
ft
1
60-day recovery sacrifice it
n n
9M 12 M 14 F 15 F
19 M 20 M 21 F 23 F
26 M
2-year sacrifice
II
If It
t
It If It
NEV 0088 2 6
it
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jftJttitoial B I O - T E S T
Hhc.
Group
T -H I
n 91 n
T -I
ir
T-n ti
T-ni
T -I
n
T-n
I
T-m
H
L iv er Slides fo r C7299 (M onsanto)
Dog No. fc Sex____________________ D isp o sitio n
27 M 28 M 29 F 30 F
(slide m issing)
2-year sacrifice D ied te s t w eek - 33 2-year sacrifice
II
10 M 13 F
17 M 22 F
32 F
30-day recovery sacrifice
ti
ii
n
it
11 M 16 F
60-day recovery sacrifice
ti
18 M 24 F
25 M 31 F
ii
ii
it
Died te st week - 29
NEV 008627
708079