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AR226-2786 '"""'"" -~'';;"''''BE^!ft^^^~"'"'"''''<
FUR DU PUNT USE ONLY
Cople* to
Haskell
E. 1. du Font de Nemours nad Co., Inc. Laboratory for Toxicology and Industrial
Eikton Road, P. 0. Box 50, Newark, Delaware 19711
Medicine
HASKELL LABORATORY REPORT NO. 138-B3
Material Tested* Uccanoic acid, pentadecafluoro-, ammonium sale
Haskell Ho. 12,037----
Study Initiated/Completed ll/29/a2-12/22/82
..Material Submitt
Central Research Development Department
Haskell Laboratory
C-8 LIVER SLIGHTS IN RATS AND MICE: ORAL ADMINISTRATION TO MALES AND FEMALES
Nummary: groups of
Ammonium pertluorooctanoate
10 young Cr^CD11'
(C8)
was
administered
orally
to
3
and 5 mg/kg
females
per
group
rats and 3 groups per species) at dose
of 10 you.ig CD--1 levels of either
mice
(5 male
of body weight. over a 3-week
The
animals
received a
total
of
9
0.1, 1.0, or 10
doses (3 per week)
observed.
It
period. Sporadic weight loss was was seen in t-he female (but
the only clinical
sign
mice. mg/kg.
Weakness
followed
by
death
not male) rats and occurred in 2 female mice
in both
dosed
sexes 10
of
All
remaining
animals
were
sacrificed
the
third
day
after
at the
last
dose and the livers were removed and weighed.
mice
A significant liver weight increase
at the two higher (1
10
was
noted
in
both
male
and
female
liver
weights
were
noted
and
in male
mg/kg) levels. rats, but only
Significantly
at the high
Increased
were
no
significant
changes
in
female
liver
weights
at
level.
any dose.
There
Procedure; The test material(as intragastric intubation to 3
aqueous 10
solutions)
was
administered
by
cy'-l
mice
(5
males
and
5
groups of
Crl:CD6' rats and
females per group per species)at
3
groups
of
10
either 0.1, 1.0 or 10 mg/kg of body weight.
animals
dose levels of An additional group of 20
(.5 males and incubated with water
5 females per only. mch
species) served
as
controls
and
was
Friday for each of j
specieswas dosed Monday, Wednesday and
consecutive weeks (total of 9 doses). Animals
weighed once prior to sacrifice. Clinical
dosing,
each
day
before
dosing
and
on
the
day
were
of
signs ot toxicity.
observaci'or.s were made daily (weekends Three days after the final dose, the
excluded)
for
sacrificed and the livers were removed and weighed,
animals were
Company Sanitized. Does not contain TSCA CBI
Kesults:
.lEecles Sa
Kac
Dose
fag/Ng)
w
(to. ot
Doses 9
ttortaj
--7]
Hat Kat itat
Kac
"at
Hat Rat Mouse Mouse
iN-jiUfkLufocea-
F M F M F M F M f
10
1 1
0.1 0.1
0 0
10 10
9 9 9 9 9 9 9 9 9
M
tu
i
i.
*-i
'j
0/5 0/5 0/5 0/5 0/5 0/5 0/5 0/5 2/5
0/5
Sporadic weight!
None
IoW' "^IS Sporadic weighs
.".'ssi'ls^ ;- -/;^.^^.3SSS
'Si-aS ^i"if \'-sS-i
Sporadic weight Sporadic weight weddkknneesss .
.^^"sw^^
;
^|gllg|l|
Mouse
i-'
Mouse
M
i
y
y,^
9
0/5 0/5
Sporadic weight
.
Mouse
f
Mouse
M
Mouse
F
U,{
9
0
9
y
y
0/5 0/5 0/5
Sporadic weight loss-
Sporadic weight loss-'
None
' 'i'^^^S^ag^
.^."^iji^^
eP_na_lta_hro_g_le_o_dg__i_ca_n_--dC_--h_a_eng^_eo_s-_*"*_.: __An_nii_maa_al_s _s_a_c_ri_fi_ce_d__3__________________
'iS ffffS'S-fsSfffS.n
mice
at
the
heavy high
livers.
and
This
effect
was
days
after
the
. '-;'-
final' dQ^S^^Igia:;algiaian^i^g^^^^i^i
evident
level.
(A
summary
intermediate of mean values
levels is
and
also
In both mBale aannidi^;^gfgfiK^i&let'^a^^^^^1J I1n" "m.al'e- r- at- s at tli^)||i^^^Si
presented In the Table.)
^
^^i'^issEs^ai.
Purity;
Contaminants; Synonyms; ^ p Ammomup
perfluorooctanoate
** Livers were removed and weighed by
Supervisor,
Acute
Investigations
G. and
L.
Kennedy,
Jr.,
Section
lexicologist.
T. P. Pastoor, Research
Keport by:
Keviewed by:
Approved by:
i.t\k:jt.a:.P:2..'9
_^ J^ate Issued: May Ib, 19HJ
' ^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^^f^j
nuskell Lab. Report f.o. 13-M3 .\unber ol pile's in Ltils rcporL: 4
J^>J^~f i^vnJL Y
Gerald L. Kennedy^, jjr.
Section Supervisor-
Acute Investigations
3 -
Company s.^-.o'----0"*""TM'"
Mouse
rt
U
0.1
1
IU
U
U.I
I 10
"increased, p<o.u5
1.92 2.33
2.81* 5.36*
1.69 1.71 2.27*
4.35*
6.38 7.33 9.12* 16.97*
6.29 6.77 8.98* 17.91*
Company Sanitized. Does not contain TSCA CBl " "-^"H.'i
: ..^SSisiSSffSs,