Document a1ZrdqpZGKV7jdp1znN5DKYJe

A c- >a Minute* of Meetings Resource* Counselors, Inc, . And Manufacturing Chemist* Association Wtihip^?qi_D, CT On Vinvi Chloride December 11 tad 12. 1974 * ORGANIZATION RESOURCES COUNSELORS ff#i t ' 0 f 0 O VINYL CHLORIDE MORTALITY STUDY STEERING UOMMirrat, A status report on the study it attached. Progress is much slower than ' planned, but it continues to move forward and should give good data in the resin fabricating area. The study will be expanded to cover all liver neoplasms rather than only angiosarcoma. Classification of exposure by type of resin used will be attempted. The list of companies declining to participate is misleading; these companies simply feel that their records are of no significant value. GAPs records should be of value and some assistance is needed to obtain their coopera-' tion (Mr. William Faciliotis of GAP's Safety Department is not convinced that the study is worthwhile). ' 1 MANUFACTURING CHEMISTS ASSOCIATION TECHNICAL TASK GROUP ON VINYL CHLORIDE RESEARCH L Minutes of the September 19, 1974 meeting are attached.. The delay of . the preceding meeting minutes was attributed to Dr. K. D. Johnson's illness. H. Confidentiality Agreement with European Vinvl Chloride Researchers. This agreement will be formally terminated since it is serving no useful purpose at the present Hmc. QQ2120 in. MCA Transportation Committee 2. NIOSH, Jerry Fiesell, agreed to do * series of tests on balk handling of vinyl chloride and polyvinyl chloride in cooperation with National Tank Truck Carriers. Six tests of monomer shipments, six tests of pelleted resin shipments, and six teats of resin shipments will he made to determine if there is a need for personal monitoring of these shipments. Mr, Sam Watts, MCA Transportation Committee, reports close cooperation with Tom Smith of S. P. L MCA plans no work in the transportation area. IV. Epidemiological Studies Tabershaw/Cooper Associates report progress in locating additional people in the current study. One hundred additional death certificates have been obtained and thirty-three more are being sought. This will yield 96% followup of the current study population. Proposals for additional work by Tabershaw/Cooper are attached. The primary proposal is to incorporate approximately 1, 500 more workers from Union Carbide Corporation's South Charleston, West Virginia plant in the study at a cost of approximately $50, QOO. Objection was made to the TCA proposal in that they propose to not use data prior to 1946. 1b.1* eliminates 16 years out of a possible 44-year history. In general, the proposals are recommended for management approval and MCA will poll the companies. TCA will provide an updated study report to the sponsors sometime in March, 1975. TCA also published an article in the Journal of Occupational Medicine (August 1974, Volume 16, pp 509-518). Epidemiology studies by the Center for Disease Control have not been reported. " Status of epidemiology studies in Europe are not Imown. V. Industrial Bio-Test Studies. A twelve -month status report of the study is due to be delivered to the sponsors soon. TCii* report will include cytology work by Dow and IBT. I'CC 002127 V. Industrial Bio-Test Studies (cant'd. } 3. XBT has requested $20, 000 in excess of their contract to cover extra costs related to meetings with numerous governmental people. The request was endorsed for payment with the proviso that all future extra costs are specifically authorised by MCA. A recommendation that $50, 000 be requested from die sponsors to cover the $20, 000 plus future contingencies was approved. MCA will poll the sponsors. A proposal by Or. R. S. Brockman, that Or. Jeffrey Kent of Northwestern University be used as a consultant in pathology studies was tabled. VI. Studie Under_gPI Sponsorship The vinyl chloride feeding study requested by FDA has been outlined. The study will involve feeding rats vinyl chloride dissolved in water. Two studies are planned-- One a 90-day study of acute toxicity to determine MTO; the second study calls for feeding rats over a two-year period with vinyl chloride in water with the highest concentration equaling the MTO concentration in the proceeding study. The basic study will cost $200, 000. Variations and problems could increase this cost to $511, 000. The work will be done by Food and Drug Research. Reports indicate that SP1 has requested Bernard Goldberg, a UNC statistician, to develop a human dose response curve for vinyl chloride. The method far achieving this curve without data on vinyl chloride concentration is not dear. VH. Dow Metah olic_ Studies States a_ . Metabolism study-- additional data Is appended to the September MCA minutes. Additional pages to complete this appendix are promised. A report on teratology will be given at the Society of Toxicologists in March, 1975. Dr. 'T. R. Torkelson was reminded that the sponsors should receive this report first. ^ r Mutagenisis studies are under way. To date, there is no apparent effect on lymphocytes. Dow has requested $ 150, 000 to continue its best-effort study on vinyl chloride metabolism another year. This expenditure is recommended to the sponsoring companies. ucc 002128 vn. Dff^ Metabolic Studies Status (coxxt'd. } 4. Mellon Institute, Or. C. P. Carpenter, reports good progress on the in-vivo end iavvitro study of vinyl chloride metabolism, after overcoming the . problems resulting from instability of radioactive vinyl chloride. Pilot runs on ret end human tissue have been completed and comparative studies of animal and human metabolism will start after the first of 1975. Initial results are expected in the first quarter. Vm. Future Research Programs Studies of lew level chronic exposure and acute inhalation exposure in laboratory animals were discussed with members of the Rail Committee { a committee of assorted governmental carcinogen experts headed by Dr. David Rail of NIEH5). The Rail Committee members saw no merit in further inhalation studies on animals at this time. This opinion was endorsed by the TTGVCR members further inhalation studies were postponed indefinitely. IX. Financingiof Ongoing Research Additional money will be sought from sponsoring MCA companies as follows: Dow Metabolic Studies TCA Epidemiology (approximately) Industrial Sio-Test Study ' TOTAL $150, 000 50, 000 , SO. 000 $250,000 MCA will seek approval by'the sponsoring companies and subscriptions. UCC1* share of this expenditure will be approximately $ 15, 000. Approval of this expenditure is recommended. X. Research on Photochemistry of Vinyl Chloride The Photochemistry Subcommittee, under Dr. R* L. May-cock of Shell, recommended that no work be until the extent of EPA* s activities in this area are knofwn. A written inquiry will be forwarded to EPA. UCC 002129 XI. Research Activities of Federal Agencies 5. Coniunur Product Safety proposes a study xt Edgewood Arsenal on Vinyl Chloride. The protocol hxs been circulxted to MCA members for comments. This study xppexrs to be x rehxsh of the VC xerosol situation and has little merit. Environments! Protection Agency plxns work xt the University of Cincinnxti under Or. E. Bingham. The protocol hxi been circulxted to MCA members for comments. ' NIOSK's Doctor Groth hxs requested xeeess to *>^*1 tissue from the IB T study. Doctor Groth will be xsked to supply details and to define his needs better. NIEHS is some research on vinyl chloride* No specifics are known. Additional data will be sought. XU. Federal Agency Reports. EFAt Environmental Aspects,of Vinyl ChjpTide/^Polwinvl Chloride Analysis of Air jpollutton Regulatory Alternatives for viayl ghtariflg- ' MCA member companies are encouraged to comment directly to EPA on these reports. > WfflSSi. Angiosarcoma of the Liver Case Registry This will be distributed by MCA to members. EPA is advertising for bids an a proposal for a chemiluminescent monitor for vinyl chloride. This is to be sensitive to 10 ppb. UCC 002130 xm. Miscellany 6 1. Unidentified Report *"y _ There is evidence of significant occurrence of lung adehodarcinoma in vinyl chloride workers* The normal ratio of adenocarcinoma to hronchipgenic carcinoma is one to four except in VC workers* 2. Cheminord if restarting their PVC plant, using air jets to move air to outside plant, a so-called air curtain. This operation was editorially applauded by Chemical Week as a technical breakthrough. The views of SPA were not obtained. 3. Norsk Hydro operates a PVC plant in a large chemical . complex employing 4, 000 people, ttiey elected to shut down to avoid a strike in the whole complex. They expect to restart after labor negotiations. 4. Dr, R. 5. Brockman of Firestone will provide a list of countries and their regulatory actions on vinyl chloride. 5. MCA is currently administering or planning to administer toxicological studies on the following: (a) Vinyl Chloride .(b) Vinylldene (c) Phosgene (d) Ethylene Bichloride (e) Fbthelate Esters {f) Fluorocarbons (g) Styrene (h) Acrylonitrile {i) Chlorobenzenes* RNWJr/ra Attachments R. N. Wheeler* Jr. UCC 002131