Document a1Y2K7zrN06E8ee1rqrvaLXbY

fiRage _ 3264 448 H25231: One.Generation Reproduction Sudy in Rs --~ TRADE SECRET Dupont763 A236 3264 Study Title F-25231: One-Generation Reproduction Study in Rats Volume 20f 3 Laboratory Project ID: DuPont-9763 AuTHOR: Eve Mylchreest, Ph.D. --~ STUDY COMPLETED ON: January 31,2003 | PERFORMING LABORATORY: EHaLskdelulPLoanbtodreatNoermyofuorrsHeaanldthCaonmdpEannvyironmental Sciences | NElekwtaornkR,oDaedl,aPw.aOr.e B1o9x71540-0050 ---- = | SERVICE Cope. edl ~~ EETY CT Company Saniized. Does not contain TSCA CBI `25231: One-Generaton Reproduction Study in Rats --~ DuPont9763 APPENDIX O INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P; MALE RATS --_ 25 `Company Sanitized. Does not contain TSCA CBI H25231: One Generation Reproduction dy n Rats DuPon.9763 --~ INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P; MALE RATS EXPLANATORY NOTES Footnotes a = Sacrificed in extremis on test day 60. b = Motility value incorrect due to particles on slide countedas non-motile sperm; data. c= eNxoclaundaleydsifsrowmasstpateirstfiocralmeadnafloyrsitsh.is animal because tissue processing for motility was interrupted bya building evacuation. d = Less than 200 sperm present; data excluded from statistical analysis. ef== AAcccciiddeennttaallllyy kkiilllleeddoonntteesstt ddaayy 4862. & = Founddeadon testday 66. Abbreviation -- = Nodua _ | -- -- = || CemPany Sanitized. Does not contain Ts gy --~ ~~ | | [i | ~~ H25231: One GenerationReproduction SudyinRats DuPon9763 INDIVIDUAL ANIMAL SPERM MOTILITY DATA IN P, MALE RATS 0GMrGo/vKeG/1D-0AY 7G5ROMUGP/K1G1/1D-A0Y Nnuinbnoar PeMrocreinlte. aNnuimmbaelr PMeortcielnet 665565777333999321 98663 665567757333999564 9%858 663377339978 9%0 665577430909 saa 656757440021 9%05 665577440043 95% 665577440065 0555 665577440078 555 8655774401902 --8 e66s55777a441117685 --55s2 6665557774442210194 520 865577442232 85 885577442254 5s5u 885577442267 55 8s5s774a2289 803 85577443310 55s4 658577443332 5032 658577549365 506 500GrMoGv/eKvG-/0DAY ARnuismbaelr PNeortcielnet sss7s7aaaa12b sa2 685577424443 58 s66555777a44444765 9555 . 665565777444454908 59925 e6s5a74s512 96 865577445543 517 665577445556 5a0 663577445587 E5d es7ase -- 657460 96 35G0R0OUMRG/VKIGI/-D0AY NAnuimmbaelr PNeortcielnet 665577446676 656577446698 s8s657577444777210 G8655r77a44t77s53 658577447776 665577447798 6ss5774488108 6s55774488320 esas 657485 5s1s 586 sa9i2 89927 jEHe 556 511 f5se 2 97 77 Company Sanitized. Doos not contain TSCA cay H25231: OneGeneration Reproduction Study in Rats DuPont.9763 APPENDIX P INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P; MALE RATS -- ~~ 258 `Company Sanitized. Does not contain TSCA CBI H25231: OneGeneration Reproduction Study in Rats DuPont9763 --~ INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P; MALE RATS EXPLANATORY NOTES Ecotnotes a = Sacrificiend extremis on test day 60. b = Sperm absent; 3 slides evaluated. = Accidentallykilledon test day 86. 4 = Accidentally killed ontestday 42. = Less than 200 sperm; 3 slides evaluated. Data excluded from the statistical analysis. f = Founddead on testday 66. Abbreviation -- = Noda --~ | . . | | | --_ | 5 -- | `Company Sanitized. Does not contain TSCA CBI F-25231: OneGeneration ReprodSutucdytiinRoatns DuPon9763 --~ ~~ | - | --~ INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN P; MALE Group T-0: 0 MG/KG/DAY ANnuimmbaelr NToortmaall AbnTaoirlmal AbnHoeravdal TaAiblno&rmHaelad 665577339921 119958 20 32 00 665577339930 129090 00 01 00 665577339956 119997 02 11 00 656577339987 129080 20 o0 00 665577349090 210907 0 3 00 665577440012 210909 00 o1 0 665577440034 119987 13 10 00 665577440065 119987 21 02 00 665577440087 119977 1 23 6655774410092 1--98 ---2- -- eoe RATS PNeorrcmeanlt 9979..50 100.5.05 9998.'5s 19090..00 19080.050 19090..50 9998.50 9989..50 9988.55 9-9-.e0 ANnuimmbaelr 665577441176 657418 6655774421090 665577442212 665577442234 665577442256 665577442287 665577442350 665577443321 656577453936 657435 GROUP III-0: 75 MG/KG/DAY NToortmaall AbnToarimlal AbnHoeramdal TaAibln&ormHaelad 119989 01 20 00 196 2 2 o 1--9-9 --o --1 -0- 119998 02 10 00 129090 00 01 00 119996 1 oa 00 119989 11 10 00 119969 10 31 00 119977 00 33 00 210909 00 1 00 198 o 2 o PNeorrcmeanlt 9995..05 98.0 9--9.5 99993.05 19090..50 9998..50 999905 9989.50 9988..55 19090..50 99.0 260 Company Sanitized. Does not contain TSCA CBI H-25231:One.Generation Reproduction Study in Rats DuPont9763 ~~ INDIVIDUAL ANIMAL SPERM MORPHOLOGY DATA IN Py MALE RATS Group V-0: 500 MG/KG/DAY ANnuimmbaerl NToortmaall AbTnaoirlmal AbnHoeardmal TaAiblno&rmHaelad PNeorrcmeanlt 657441 657442 129060 00 40 00 19080..00 656757444434 119977 02 31 00 9588.55 657445 657446 119987 00 32 00 9989.150 665577444478 119995 3 12 00 9979.55 656577444590 129090 1 00 19050..50 665577445512 119965 11 3a 00 9987..05 657453 657454 119965 20 a3 00 9987..05 665577445556 119983 02 25 0 999..50 656577445587 119973 22 15 0 998..53 665577a45600 19r5e ---2 --3 -o- 9=7.5 ~~ GROUP VI1-0: 3500 MG/KG/DAY ANnuimmbearl NToortmaall AbnToairlnal AbnHoeramdal TaiAlbn&ommHaelad PNeorrcmeanlt 665577446667 119965 20 25 656577446698 119979 00 31 656577447710 118989 2 25 665577447723 119997 11 20 665577447745 119965 20 21 657476 196. o : 6655774477874 1j97y -2 --1 657479 199 1 6655774488100 14534 04 21 656577448832 19.5 n2n --3 665577448845 119988 00 22 00 9987.'0s 00 9998.55 0o 9994150 o0 99981.55 00 9989..05 o 980 --0n 9a8.5 99.5 00 9977..70 e0e 9--7.5 00 9910.0 -- 261 -- Company Sanitized. Does not contain TSCA CBI H:25231: OneGeneration Reproduction Study in Rats -- DuPont9763 APPENDIX Q INDIVIDUALANIMAL SPERM AND SPERMATID COUNTS IN P; MALE RATS --_ --~ 2602 `Company Sanitized. Does not contain-- TSCA CBI | H25231: One-Generation Reproduction Study in Rts DuPont9763 ~ INDIVIDUALANIMAL SPERMAND SPERMATID COUNTS IN Py MALE RATS EXPLANATORY NOTES Footnotes a = Sacrificed in extremis on test day 60. b = Accidentallykilled ontestday86. = Accidentallykilledon test day 42. d = Founddeadontestday 66. Abbreviation -- = Noda --_ --_ RR Company Sanitized. Does rot contain TSCA CBI F-25231: OneGeneration Reproduction StudyinRats DuPont9763 --~ INDIVIDUAL ANTMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN By MALE RATS GROUP 1-0: 0 MG/KG/DAY ANnuimmbaelr "FerEpciaduiddaymal SPpeerrmg cauda eTersttiecsutliasr SpermaFteirdgs testis 665577339912 330527..87 1907104..72 181747..71 19660..42 665577339930 336213128 1390913..57 119800..00 111145.42 665577339956 320767.31 897780.84 116738137 114081.79 665577339987 3320797738 11015929..58 2118371096 114272.38 665577349090 322858..08 11028384070 11662183 4 1103374372 665577440021 321615l.04 995278.84 1718671006 112118108 665577440043 282882..89 1828784.28 118776.56 113209.127 656577440065 23812495 191064.348 117655143 110128172 665577440078 326258.45 10115024..22 11738931 11159119 -- 6e57547100 286.4 115--3.0 11--5-.8 5--6.7 GROUP 111-0: 75 MG/KG/DAY ANnuimmbaelr "FerEpciaduiddaymal SPpeerrmg cauda TPeesrtitceustliasr SpermaPteirdgs testis 665577441167 3331331.23 10133791.061 210520..80 11223.025 665577441189 331.5.57 132788..23 149.172 11204.355 665577442210 331343.57 111223267.31 1r63e.e1 1578..15 656577442232 2390581180 110121357039 2200121718 113222.114 656577442208 231028.11 1058436..68 18167.051 112290065 665577442267 232761.22 m9744..77 118613.178 1110513.64 665577442289 2820231.50 1088858..26 18167.853 11102151 656577443310 228808.86 1832001..52 115769.51 1134790.01 665577443323 33026163.2 112363050151 1168200.50 110102182 665577549355 235212.71 15128479.730 115515 110064.69 --~ Wt Company Sanitized. Does rotcontain TSCACBI H-25231: OneGeneration Reproduction StudyinRats DuPont9763 ~~ INDIVIDUAL ANIMAL SPERM AND SPERMATID COUNTS (MILLIONS) IN P, MALE RATS GROUP V-0: 500 MG/KG/DAY ANnuimmbaelr PerEpciaduiddaymal SPpeerrmg cauda BToerstitceusltairs SpermaTotridgs testis 656577444421 333194.50 1258858..30 116462.60 9925..78 665577444413 3223990010 12100141.731 125176085 112195.s0 665577444465 3320120058 110360277.39 212631193 112070103 665577444487 320332104 11035770.60 118976..62 1121601716 665577445409 326887.53 912620.8.07 1178921152 1120267.57 665577445512 327070.51 1502102..29 118321a8 113308138 656577445543 2277931.37 1095356..31 16146917.6 11042266 656577445565 2288070.66 15113008..62 115693151 19275.758 665577445587 23001..41 1120062..70 1610621125 110089..40 ~ 6655774456900 31-8.0 oC 1625.6 ol 167.8 oo 127.6 GROUP VIT-0: 3500 MG/KG/DAY ANnuimmbaelr PerEpciaduiddaymal SPpeerrmg cauda TPeesrtitceustliasr Spermabetridgs testis 665577446667 2392567.82 1015715..48 127139.82 114056..86 656577446689 3302560.12 10113366..40 115898..08 19191.12 665577447710 3100105 1614480..72 1186753.64 115353.020 665577447732 283256..52 16140854..10 2016581.44 118s8 - 656577447745 229869.09 11326204.45 - 11689a5 110178.24 - 665577447786 22805639 1052947..76 117601017 112046107 665577447779 28--4-.1 130-3.1 17-4.2 12J0.5 665577448801 22783861 111067550.52 115680..42 1120080122 6655774488320 28p8.8 12-28.7 1j5o0.y8 10l8.9 665577448854 2298975313 11213005..51 151208.026 19046..11 --~ %5 Company Sanitized. Does not contain TSCA CBI I H:25731: OneGeneration Reproduction Study in Rats ~~ DuPont9763 APPENDIX R INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION INP, FEMALE RATS we `Company Sanitized. Does not contain TSCA CBI | H25231: One-Generation Reproduction Study in Rats DuPont9763 INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMETERS ~ DURING PREMATING AND COHABITATION INP, FEMALE RATS EXPLANATORY NOTES Note Test days 76-90 = Cohabitation Period except for Animal Numbers 657510, 657584, 657585 (Test Days 77-91 = Cohabitation Period) Footnotes a Evidence of copulation detected, but animal did not delialviteterr. b No evidence of copulation was found and no litter was delivered. No evidence of copulation was found but a litter was delivered. To calculate the Precoital Interval, the day of copulation was assumed to be the lastestrus during cohabitation; the days of persistent diestrus that followed were excluded from calculations since the animal was pregnant and thus, was not cycling normally. d Due to the death of the first male during cohabitation, the female was cohoused with a second male from the same group on test day 86. P Abbreviation -- = NoData --_ ET -- `Company Sanitized. Does not contain TSCA CBI | | H-25231: One-Generation ReprodSutucdytiin Roatns DuPont-9763 --~ INDIVIDUAL ANIMAL ESTROUS CYCLE PARAMSTERS DURING PREMATING AND COHABITATION GROUP II-0: 0 MG/KG/DAY nn NOMBER WOoWwBsERoOrF PERoCFENT PoERFCENT | PERoCrENT cMrEuANz eREcOITAL DATA DAS IN DAYS IN DAYS IN LENGTH INTERVAL COLLECTION ESTRUS _DISSTRUS PROESTRUS (days) (days) 656577449921 2221 12978 65258% 1s9e% 45..0303 21 665577449943 22a2 235288 56088% 2o5t8 42..0000 a2 657495 2a 25% 63% 13s alo a 6655774499762 22a2 299%8 7771%% uoss a4l20s0 a2 665577449998 2233 31038% 6710%% 197%% 4s.l0o0 33 665577550001 2233 1272%8 76818% 7as 4s0o0o a3 665577550032 2231 214280 7512%1 2u6s0 4a.300 31 665577550058 2222 259%8 5787%% 117%% asllo0o0 a2 665577550076 2230 22028 5582%8 123688 543030 33 ~ 657508 2 368 59% ss aloo 2 6655775501902 225 11868% 5783%% 196%8 aa.70s 52 --~ 268 Company Sanitized. Does not contain TSCA CBI F-25231: OneGenerationReproduStcudtyiinRoants DuPont9763 f INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIAOMNETERS GROUP IV-0: 75 MG/KG/DAY aman NBER WoOMwDsERorOF PERoCrENT PERoCFENT | PERoCFENT cMyEcAuNe eREcormu DATA DAYS IN DAYS IN DAYS IN LENGTH INTERVAL COLLECTION ESTRUS _DIESTRUS PAOSTRUS (days) (days) 665577551167 2210 22498% 570188 2s1t8 a4l.o0o0 a1 657518 6575190 3234 292% 761988 172%0 4a.lo0o0 o3e 665577552210 221 3135% 65288% 189 a4l.o0o0 11 665577552232 223 32368 7E48l 808 aalloooo 34 665577552254 2251 2190%8 6520%% 11698% 45.0000 15 665577552276 2212 21248% 771388 uses 45..0000 12 657528 22 360 59% 5% 4.00 2 657529 3a 18% 63% 9% 440 4 665577553301 227 92%2% 6683%% 1153%8 44.6000 H7 /~~ 665577553323 221 222988 75608% 2or% 44.0000 14 665577553345 2254 22898% E72Y8 10838s 44.0000 45 --_ 2% -- `Company Sanitized.Doesnot contain TSCA CBI  H25231: OneGeneration Reproduction StudyinRats DuPont9763 --~ INDIVDIUDRUIANLG APNRIEMMAALTIENSGTRAONUDS CCOYHCALBEITPAATRIAOMNETERS GROUP VI-0: 500 MG/KG/DAY man NUMBER WONDER OF PERCENT PERCENT PERCENT WEAN -- baDAsTAor DAYoSF IN DoAYFS IN DAYoSF IN LcEvNoGiTeH eIRNeTcEoRrVmAaLL COLLECTION ESTRUS _DIESTRUS PROBSTRUS (days) (days) 665577554421 2230 225288 6715%% 80% 42.0000 34 665577554438 222 2253%% 5707%% 2o5s8 aallooo 32 665577554455 2231 21228% 661788. 1i7w% aallo3o 31 665577554487 228 25a% 852488 1281s8 s4li0s0 53 657549 22 238 sat as aloo 2 657550 3a 268 65% ov 4.00 5 6655775555210 23a 2118%8 75188% 1828 a4.l0o0 4 4 665577555534 221 3239%% 558288 113s8 aallo2o0 .1 665577555565 2232 320388 5601%% 297%% 44.0000 23 --_ 6655775555875 232a 218188 6749%% 1088 44.6070 2 6655775556094 3213 22638% 66558%. 153%8 44..0600 31 --~ 270 `Company Sanitized. Does not coatain TSCA CBI H25231: OneGeneration Reproduction StiundRayts DuPont-9763 --~ INDIVIDUAL ANTAL ESTROUS CYCLE PARAMETERS DURING PREMATING AND COHABITATION GROUP VIII-0: 3500 MG/KG/DAY TT An J woomarEsRoror PERcEW oF macaw or emRomNT oF WeAN cvoLs eRecormAL DATA COLLECTION DAYS IN ESTRUS DAYS IN _DIESTRUS DAYS IN LENGTH PROBSTRUS (days) INTERVAL (days) 657566 34 se 75% ss 10.00 4 6565775566788 2312 125488 7562%8 208 447050 11. 6655775567902 2272 22368%. 6678%% 79%% 44..0000 72 6655775577210 3224 128388 s77ae 90% 444000 52 656577557734 2234 133888 7683%% s0t% 44..0000 3a 6655775577568 3231 713088 265782 2308 5a.300 113 657577 23 268 528 228 4.00 3 6655775577898 2211 224488 a7s68 2098% 44..0000 11 665577558810 2234 1a328 750488 38% 540.0500 31 r~ 6655775588328 2221 322483 570%8 0188% 44..0000 21 || 656577558854 2264 1197% 8737%% aor 4al0o0o 35 | -- 271 - Compas"ny Sanitized. Does not contain TSCA Cay H25231: One-Generation Reproduction Study in Rats --~ DuPont9763 APPENDIX INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES DURING PREMATING AND COHABITATION INP, FEMALE RATS m Company Sanitized. Does not contain TSCA CBI | H25231: OneGeneration Reproduction Study in Rats DuPon9763 INDIVIDUAL ANIMAL ESTROUS CYCLE STAGES rm DURING PREMATING AND COHABITATION INP, FEMALE RATS Notes EXPLANATORY NOTES Test Days 56-76 = Premating Test days 76:90 = Cohabitation Period except for Animal Numbers 657510, 657584, 657585 (Test Days 77-91 =Cohabitation Period) Abbreviations D = Diestrus E = Estus P= Proestrus X= No sample or stage couldnotbedefined from sample. `Footnotes a Evidence of copulation detected but animal did not deliver a litter. No evidenceof copulation was detected and no litter was delivered. --_ No eviodfecopnulcatieon was detected but aliter was delivered. | | -- | | me Company Sanitized. Does not contain TSCA CBI PE C~ d ESTeT L Tr R EE 5 | L E lRE :: CNE EER EE EE ii DETER Ee ; :CE EE reE EE ii E Hem E e EEe E 5 gp ME EEE EEEeRE E ; ssiighETp E AEe C ee J VEEE e EE S UBI|NE I [ E ccRrcEriE cEnE rnniEee: L| l1 | E EE HeepEe ERheE EB | | 3 BE f Ep oEC EEED |= HERB EBEEEEEEERBRRERBEEEEE . g: E ETE T TER==I z CE ee o eEaE . | CE ee OEeE eE g3 || E EE E EEEEE 5f 8 || E ERE E EEEe TE i: gos || [[EEEEEE EEEEE EE 3: ii.|[E|EEEe EE E [E Eee EE 32 ESR EBPEac:he BEEWRe SEEcSl-o R-aE- - EEE i I~ |e g |seioi[ eepcE c EE e FS s H [EEEEee EEE { $s e8|| [ ECCEREEEH E E oR FEPB| E[ECop- - Bc EER- GE EE-EE-BE EE F50E0E8 | o [CEr E EEEcl EE EEE F 0 E 1 EEiGElEEe E EEE EL | 4 f F || C[cElEeEEE IC Eflo l) i [(EcJi =<=R=lof=oel [oclooofR eae) | ic EEEEEEEEK-EER-E-EEEEE- - EE-BE-EE-EEEl- I~ = B85 5] 5| 5) &| 5 Bl 2] B| &| 5] &| 5) 5] &] 8 5) &] 5 5) | 7 3 LEE T eEeElTE TreTTT] 22 5 || E EO eE e T Te E 5g 8 || E EE eE e EeeR i: 88 || [ E e eae teerTTl Tefe fel] 3i 5 || E ECe COEe ETE 3i | I Er |E[cC l leEEelCE[ER-eCENNNENEN : El| e ElocemeBeRsEE oF BEE 6 i 2Fg 7o||g[AEERREoE R SolRJl Iso 2 3E5RL| E C-r-e - CEE BEolECo-EED i 3B8|E: [ofcaeeeolaoCoEoEEA5 EERE 51035 || [ EEE ccleEa ln o er A 3g | [EEcRmEl EEB REpCT |IBEBNEE:E cEocEecE e CEEEECE-EEEE 6El i3 | [E 2 =o< la < eelA - -f-o}l 2: [B=e=e]psoEoe=]eo]op=o.6o.offBoa[e gl EEEEEEEEEEEEEEERERERER | er |~ Zg 2 u EEE JT TT TTTTITITT] 3 5 i (ehaflala[Tl/T TTT] g [apa falTTR TTT TTT] 2 2 [S|ahp al Ta T TTTTTT 3 [l | fee TTT] g 8 [Sh =aEskT/eT TTT] i EECRENCEEN -EEEEEEENEE 2 [Bae|| LIT] fa] 3 i5 fel = EE |e) z F ofR|EE E-EECREEREEREEEl-aH - Ea E EEE E 5 i2 HEREC: -c8 60-- B 8EE |In [ oFle|oEeREBme-Bi -ol E EEE- -EEE| - g {lS allelol oCSp Co| 8 g8 f (|Hegle elakae aal e aiceE eo ta) e|lee EE hla ec RE a 8 | [clelafatalalalalaly slat aialaialala 2 | [Slefdelaioly cia SE oo] [12 3g 2 ((cFleelacl-SrIER=ce palo lesia p le a p El | g3 28 BBE-E E8-EEE E- ~E8 - - -EEE- EE8BE z: 5CNEL [clea- sRELa GGalalLa atEaE]-sp -aR6EalDEoEle]] H [eR alalalaallARE = Sl =oa]aff]ole] 515) |a[] |clal~R alofl | [Glalel alelalala afsgol] [= ==] 8 HEE- -BEBE-BREE- BE-BED] { 125231: OneGeneration Reproduction Sudy in Rats -- Dupon:763 APPENDIX T INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION --~ EE EQ -- Company Saniized. Dossnotcontain TSCA CBI H25231:OneGeneration Reproduction Study in Rats Dupont9763 ~~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: P; GENERATION EXPLANATORY NOTES Abbreviation ~ = NoData --_ -- EE emPany Sanlized. Doss not contain Tach cg H_ 25231:Ove Genersion Re_ productionSwdyinRats _~ DuPon9763 ~~ INDIVIDUML MATING DATA AND GESTATION LENGTH: 2; GENERATION GRoves: 11-0,1-0 DOSE: 0 MG/KG/DAY TBoONGLEy WNMEm9 POUBGG/RSVPEEDRM IMAMLEA#L2 FOLBUSGE/RSPVEERDM PLRIOTDTCEERD LGEEGSRT(AdTaIOyNs) GGorruiaenns eeerrseeos ::. ::. Fi2S GGGrrraiissss cEesa7rr3a0vv5ed ::: -:: za@ GGGrrriaaecsre eee7as3rr0 ::: ::: i55 GGr0e0n Goa ee7s0a0 eso :: i ::: iii GGGrrrooosss eeerrraaaoonsd :i1 i:: 2aa GGGaarrrossoosns eeesssr77aaaoootee ::: ::i @ai GGrereieserean :: 2: 52 --_ --~ 0 Company Sanitized. Doesnotcontain TSCA CBI F:25231: One-Generation ReproductionSudyinRats DuPont9763 ~ INDIVIDUAL MATING DATA AND GESTATION LENGTH: 7) GENERATION GROUPS: TU-0,III-0 DOSE: 75 MG/KG/DAY FAENMDADLLEY ee775567 rs7ss1s9 7e572s0n 7552:32 7as572s24s a7s57s227s Gass77ss2289 6e7r53s0 767553323 e6775533 MAAMLEA#L1 6es5n1a11)s sessinaaiiss 65s7s4n2a0z sesnnaaz eessvraazzes sesnvaazs 6e55774228 6s8s7v4a3n0 s68m7a43:3 e8s77a936s POLBUSGE/RSVPEERDY +: o: :: :: :: :: -: ::: :: AALNEDAL#S2 POLBUSGE/RSVPEERDY PLRIOTDTUECRED +: 22 i: 1: i: ii .: .2 22 32 LGEENSGTTAHT(IdOaNys) 222 2 322 232 25 2fr 2"a 5"a 23 32 --~ ~ 2 Geobssteartvieodn. length could not be calculated since no evidence of copulation was 21 Company Sanitized. Doss not containTSCA CBI H25231: OneGeneration Reproduction Study in Rats DuPont9763 --_ INDIVIDUAL MATING DATA AND GESTATION LENGTH: P: GENERATION GROUPS: VI-0,U-0 DOSE: 500 MG/KG/DAY AFRNODLGEL ~~ AMNADLGEAL#S1 ess7rsas1 eessvnaaaazn 5577554434 6e5s7744443d 55775544s6 esss77aadass 655774587 esss77aa4d7s 65769 57550 66557744540 ess77ssss21 esssnvaassy 5Gs775s5s3a sess1Taassst GGss775s5556 ee5s774a5s6s 5s175s5s7e ee5si1as8s a7s576ss09b sess7Taa6s0s POLBUSGE/SRPVEERDM :. :: :: :: :-.:: :: := -7 MAALNEDGL2 ss7ass OPLBUSGE/RSVPEEDRM . PLRIOTDTUCEERD ++ ++ +: ++ +: .+ :: -:: :: LGEENSGTTAHT(IdOaNys) 22 22 22 22 "2a 2"3a 22 22 22 2 --~ Geobssteartvieodn. length could not be calculated since no evidence of copulation was ~ b Fneamlael.e was cohabited with a second male due to accidental death of first 282 Gompany Sanitized. Does not contain TSCA CBI H25231:OneGenerationReproduction SudyinRas DuPone9763 _ INDIVIDUAL MATING DATA AND GESTATION LENGTH: Py GENERATION GROUPS: VIII-0,VII-0 DOSE: 3500 MG/KG/DAY NFNROOMLAELE WuOpO6L1 POLBUSGE/RSVPEERDY WJAWLAEL#S2 EOUBGS/ESRPVEERDM PLRIOTDCEERD LGEEWSOTTA(TdIaOyNs) SSesss1seees sssnaaessessr -3 : =. a= < = GS7r5e6 esssrtaasns i: sim enn - =: =2 : Za GGSrreeaman eeeranannn Ii3 ::: =1= GGGrrraaemes reeaaarrnanrese i1i -: 5z : @ SSGrrreeaeee aeesraraasnme 3:i -: 5& : 1 GSGrreseeen eeeassvreeesn :: i =: =# : SGrhseesn eernasee :: :: #i --_ --_ a Geobssteartvieodn. length could not be calculated since no evidence of copulation was | | 5 `Company Saniized. Does not contain TSCA CBI H25231: OneGeneration Reproduction Study in Rats --~ DuPont 9763 APPENDIX U INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: P; GENERATION --~ | --~ E) `Company Sanitized. Does not contain TSCA CBI H-25231: One-Generation Reproduction Study in Rats DuPont9763 ~~ INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Py GENERATION GROUPS: II-0 DOSE: 0 MG/KG/DAY Animal Number Pups Born. Number of Implasnittaestion Implantation Efficiency 657491 4 4" 100.0 657492 18 18 200.0 657493 1 12 91.7 657494 15 15 100.0 657495 12 12 100.0 657497 16 17 94.1 657498 1 14 100.0 657499 13 13 100.0 657500 1 12 91.7 657501 14 1a 100.0 657502 13 14 92.9 657503 13 16 81.3 657504 15 15 100.0 657505 12 12 100.0 657506 10 10 100.0 657507 14 15 93.3 --_ 657508 15 15 ' 657510 12 12 100.0 100.0 | |~ | 285 | Company Sanitized. Does not contain TSCA CBI mn cette No nso mast--t--r --a A Souoan--sR 7, SORT m mmW m gmdmr. mWemme | | = Com Sts. os rico I H:25231: OneGenerationReproduStcudtyiinRoants DuPont9763 Po. INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: Py GENERATION GROURS: VI-0 DOSE: 500 MG/KG/DAY ANnuimmbaelr PBuoprsn. ImNpulmabnetratoifon IEmfpfliacniteantciyon sites 657541 un 657542 13 13 15 84.6 86.7 657543 4 1 657544 15 15 100.0 100.0 657585 13 657586 15 17 15 76.5 100.0 657547 1 1 657548 8 8 100.0 100.0 657549 12 657550 1 12 12 100.0 51.7 657551 12 12 657552 4 15 100.0 53.3 657553 4 15 657554 10 13 93.3 76.9 657555 13 13 657556 15 16 100.0 93.8 657558 12 12 ~ 657559 1 100.0 81.8 657560 13 3 100.0 I~ || || 27 `CompanySanlzad. Does notcontain TSCA CB || F-25231: OneGenerationReproduSucdtyiinRoatns DuPont9763 --_ INDIVIDUAL IMPLANTATION SITE DATA AND IMPLANTATION EFFICIENCY: P; GENERATION GROUPS: VIII-0 DOSE: 3500 MG/KG/DAY ANnuimmbaelr PBuoprsn. Imupmlabnetratoifon IEmfpfliacniteantciyon sites 657566 12 13 92.3 657568 12 13 92.3 657570 16 18 88.9 657571 13 13 100.0 657572 12 14 85.7 657573 10 90.0 657570 13 13 100.0 665577557767 1132 13 13 100.0 92.3 657579 12 15 80.0 657580 16 16 100.0 657581 1 1 100.0 657583 1 16 87.5 657584 12 14 85.7 657585 u 1 100.0 ~ ~~ | 288 | Company Sanitized. Does not contain TSCA Cal H25231; One-Generation Reproduction Study in Rats Dupont 9763 APPENDIX V INDIVIDUAL PUP SURVIVAL: F; GENERATION --_ ~~ -- wm SE Company Saniized. Does not contain TSCA CBI 125231 One ennRerocidyonans -- INDIVIDUAL PUP SURVIVAL: F; GENERATION Abbreviation EXPLANATORY NOTES - = No Data Dupons76s ~ |~ | --_-- x Company Saiz. Dows rtcontan T--EGACE! H:25231: OGneeneration Reproduction Study in Rats DuPont-9763 INDIVIDUAL PUP SURVIVAL: Fy GENERATION ~~ GROUP: IT-0 DOSE: 0 MG/KG/DAY NUMBER OF PUPS ANNUMABLER BORN BAOLRINVE PREDCAUYLL4ING PODSATYCUL4LING DAY 7 DAY 14 DAY 21 665577449912 1a8 148 184 48 48 48 48 665577449934 115 1u5 11 88 88 88 85 665577449965 12- un- u- 8- 8- 8- 8- 665577449978 116 116 116 88 88 88 88 665577459090 113 113 1u 88 88 88 88 665577550021 113 1133 1133 88 88 88 88 665577550034 1135 315 153 88 88 88 88 665577550056 1102 1102 1u0n 88 88 88 88 665577550078 1145 115 11s 88 88 88 88 665577551009 12- 12- 12- 8- -8 -8 8- --_~ NUMBER OF MALE PUPS ANNoTMHBAELR BORN. BAOLRINVE PREDCAUYLL4ING PODSATYCUL4LING DAY 7 DAY 14 DAY 21 665577449912 28 28 28 21 24 2a 2a 665577449934 85 85 85 5a a5 Ha 5 665577449356 7- -6 -5 a- "- 4- 43 665577449978 77 77 77 44 a4 44 44 665577459090 86 86 85 .a oa a4 4 665577550012 65 65 55 44 44 a4 44 665577550034 65 53 69 44 4a .4 44 665577550056 76 57 67 45 45 45 45 665577550078 106 657509 - 106 106 - - a4 - 44 - a4 - a` : 657510 8 5 8 4 4 . 4 I~ | | 1 Company Sanitized. Does not containTSCA CBI H25231: OneGenersionReproductionSudyimRats __ DuPonuo763 --~ ANuNMIBELR es6757a4s912 665577449543 665577449356 663577443987 663377540909 663377550020 663377550083 665577550056 656737550078 ~~ 636737550290 umpoER 665577249012 68557740934 665577423956 865577249987 85577540909 665577350021 63377330083 656757550056 | 886555777335000987 | 657510 | --_ INDIVIDUAL PUP SURVIVAL: F, GENERATION Group: 1-0 DOSE: 0 MO/KG/DAY NOMBER OF FEMALE PUPS BORN ABLOIRVNE PREDCUALYLSING PODSATYCUL4LING DAY7 DAY 14 12 pH]2 102 3 3 3 a2 3 :2 3 32 3 Fr]s 05 10s 33 33 a3 57 o7 52 aa a4 a-a 55 8 :5 7 55 7 33 3 ss 4 3a a 776 77s 77 5 33 i 44 4 a3 a 3s 3 3s h 35 3 33 3 33 3 33 a :5- -5 : a9- 33. h3n- -3 a NUMBER OF PUPS SEX RATIO (WALES) % BORN ALIVE 0-4 DAY VIABILITY o0.l5a0 00..3733 20138 00..5404 ooass. 00..4463 o0llse0 ol017500 =00..4701 0.67 1100000.00 101000.000 91=17 1100000.00 110000000 10057205 T0o0000 1100001100 10100020.00 100.0 1100000.00 1100000000 100-00 1100007.00 1010007000 1100000000 110000l000 109017.07 10T0o>.00o 100.0 Dav 2: a2 i3 -i aa aa aa ii 3i 33 i: LacmaTTNIDEoXn 1100001.00 110000l000 To-oo T10o00.00 110000.00 110000.00 1100000.00 0T000l00 01000-.00 100.0 | EE) Company Sanitized. Does not contain TSCACBI H25231:OneGeneration Reproduction StuindRayts INDIVIDUAL PUP SURVIVAL: F, GENERATION ~ GROUP: II-0 DOSE: 0 MG/XG/DAY NUMBER OF MALE PUPS aNnOnMoBaELR + BORN ALIVE 0-4 DAY VIABILITY LACTTEATRION 665577049912 665577449938 656577449965 656577449978 665577459090 665577550021 656577550083 656577550056 665577550087 658577550100 --~ 110000..00 110000.000 110000.00 110000..00 110000.00 110000.000 85-.7 100- 0 100-00 101000..00 110000.00 110000.200 1100000.00 101000..00 11000000 110000000 110000..00 110000.00 110000.700 110000..00 110000..00 1100001.00 1100000000 110000.000 1100001.00 110000l00 1100000000 100-.0 100-.0 100-.0 NUMBER OF FEMALE PUPS || AovumBaELR BORN ALIVE 0-8 DAY VIABILITY zacTTiameTxION 665577449921 110000..00 110000..00 1100000.00 665577449534 110000.000 110000..00 110000..00 665577449956 100-.0 100- 0 100-.0 656577449987 110000.00 110000..00 110000.100 656577540909 - 101000..00 101000.100 110000.000 665577550012 18070.050 110000..00 110000..00 656577550083 110000000 110000..00 110000..00 665577550065 120000.00 1080303 110000.000 656577550078 101000..00 101000..00 110000000 665577551009 100-.0 100-.0 100-.0 --_ DuPont9763 3 Company Saniized. Doss not contain TSCA CBI 325281 One Geprion Reprod Sty nts Dupons7es ~ DIDIVIDL PUP SURVIVAL: 7, GENERATION anoue: 1v-0___pose: 75 wares women op sues mama sow BAoVwsR pscBuLaLING poSBTAOYUALLING DNO DA awa oewmemer oB Bnn 5 w5o3 Bn Fr :: .;; : .5; : .: : .:: : SSgehEnn an o@u 2 on u5 nom5 3: :i:; :i: 5 5i5 5 ::: 3 WawaEee oWaw5 er aw oown5 oai5 wow 5;;; i55 : i: ::: : Gaaaamp o#B w0 noB n B0B pH :: 5:; 55; : ::; ; ::: : ~ FSFFEHTHs a oSaE5i a5i 5ii: 5ii; 5iii i:3` amen op wae rues mfoaon sow unomei preecuLaLIvG RoeSTROUeLLING DWT oA awa aaEsaIe 89 EH :.5; .:5: .ii `.i` i`i: `i`` SFeaEn 3 ;;: 5;; 5ii ;ii ii; ;i` SoGGaaan nd3 wed i5; i5FE ii :: i:i : i5 3 i5i 3 . gE FsE aow w ow wow ii5 ii5 ii: ii: fEarHad ::i :;i i` ii i:: i:{ i|| E rT o 657533 6 i6 5i6 4:i 4:i 4ii 4ii ~ | TM CompanySanized.Docs otcontain TSCA Cal 125231: Orne GenerstionReproductionStudyin Rats. Duont763 INDIVIDUAL PUP SURVIVAL: F; GENERATION ~ Group: 1v-0 pose: 75 we/Ka/oaY [Ee ------ mAmEon sory ABLOIRVNE PREBCUYLLI4NG ROBSATYCU4LLING oAY7 DAY 14 mayan Ee3s777855112766 :is sis sis ii. 33a i4 ii. i6s377552105 :: 657531 : :2 3 :: 3 5: 2 i5: 15: i5: G65s7775533532 3ii 7i: ;ii i43 i1i iii iii S5377533265 33 637577 : 33 : 33 : 33 i :35 i33 i33 6Gi33s777355332508 33S 335 33s i3: i3a i33 i3i 536577755533231 i82 i:2 5i2 i:2 3a3 ii2 1i2 ~~ E7755338 :2 :: :- i: i: i: i: nme oF puRS jANeDrI es77351176 EEE7775512180 6653577753533321 i 66E33777535332465 p635e77353257 i| 6E33777555333130 J GE377r55a33s43 -- SEX RATIO GALES) o0l.62s 0o.l2 2e7 20o11l33s06 oa0l.1&75738 aoalllee 3[015e23H ao1ll16a0s0 % BORN ALIVE 110000..00 1020002.000 1010000.00 12000000077000 11500003..800 110000.000 111000000...000 1100000700 0-4 DAY VIABILITY 110020000...600 102000:0.00 1100007.00 1100w0000o00 111000000070000 111000000.00000 1010500.0800 Lactfarzion 111000000.0.000 11100000000.000 12100000000.000 121000000.00000 11100000007.000 1110000000..000 1000 -- -- mo Company Sanilized. Doesnot-- contain TSCA CBI 125231: One-Generaton Reproduction Study in Rats --~ jAw= 656577551176 656577551189 665577552201 665377552223 665577552245 665577552276 656577552289 656577553301 656577553323 --~ 656377553345 aNmouoBEnR 665577551176 665577551198 656577552201 656577552232 656377552250 6e5577552267 | 665577552298 668877553301 665577553323 665577553354 INDIVIDUAL PUP SURVIVAL: F; GENERATION GROUP: IV-0 DOSE: 75 MG/KG/DAY NUMBER OF MALE PUPS. BORN ALIVE 0-4 DAY VIABILITY acITNADTEIXON 1100000.00 110000%.00 110000%.00 100-00 1002J 0 100-20 101000.000 1100000.00 110000.100 1100000.00 101000000 110000.100 110000.000 1010000700 1100000000 1100000000 1100000000 1100000000 108050.07 1100001000 1100002200 1100001000 1100001100 1100000.00 101000000 1010000.00 1100000.00 110000.000 109000.00 110000%000 NOMBER OF FEMALE PUPS BORN ALIVE 0-4 DAY VIABILITY LAICNTDAETXION 101000.000 100-.0 110000..00 1100001000 1010000000 1010000l00 101000000 1010000000 1100001000 100-.0 1010000.00 110000..00 10000 10:00 110000..00 110000.000 101000000 1100000.00 1010000000 - 1100000.00 101000..00 110000.000 1100000000 1100001.00 1100000000 110000..00 1100001000 - 1100020000 100.0 100.0 DuPont763 | 96 `Company Sanitized. Does not contain TSCA CBI | $5231:OneGenersion Reproduction Study in Rats Dupont9763 INDIVIDUAL PUP SURVIVAL: F, GENERATION ~ GROUP: VI-O0 DOSE: 500 MG/KG/DAY EER OF PUPS ajmievne sow MBOVRNE PRECDUALYLI4NG POSDATYCUL6LING DAT DAW la DAY 21 666335777355444321 Fo11la prn1e 151 ee 888 s88 ::o 666555777535444654 i13s3 FbeIS]s ii3ss 6ee 888 888 358 65777355444875 Fo2l3 112o 213 58: 888 588 88 883377538510 F1o2y Fno 120 55 88 e8 se33s77155s58s302a 11104 ip1oy 1u10 888 :e 888 :`. 663377555865 bt3] iFesd fits 88 5: 88 58 666353777355355587 125: 25: 25: 5`: 5:: 8:: 8a2 --_ 67360 13 3 3 5 8 3 8 NBER OF WALE PUPS janoovna more ABOLRNE PREDCUWLLI4NG PODSATYCUL4LING DAY 7 Dav 14 oav au 6e37755412 85 55 :5 3a a4 a4 3a 1 66553777555444534 ::5 3:5 5:5 1ia ii4 ii4 114 | 8g35377753544878 375 357 357 35a i5` 33` 3s4 G65333777553855501 5a3 5@ : 5 3ai ia3 aa3 1T3 s5835777533555320 103i 1032 032 5i1 5ii 5ia 3ii G88333777355855576 5:7 :7 :`7 :ai 2i3 :i3 33 {|{ 86G33777355655058 525 523 525 i25 i25 i25 i25 om ll 2 One dead pup vas wenseexable at birch. 7 CompanySanilized.Does nolcontaTSiCnA CBI H:25231: OneGeneration ReproductionStuyinRats DuPont9763 INDIVIDUAL PUP SURVIVAL: F, GENERATION ~ GROUP: VI-0 DOSE: 500 MG/KG/DAY NUMBER OF FEMALE PUPS ANTYAL BORN ABLOIRVNE PREDCAUYLL4ING PODSATYCU4LLING DAY 7 DAY 1 DAY 21 NuMBER 656577554412 55 55 55 a4 44 4 4 4 h 665577554423 55 5 55 44 44 44 a4 665577554465 88 85 88 a aa s4 aa 665577554878 52 52 52 52 52 52 25 656577558509 7a 7s 54 a4 3a 4a h 656577555512 57 75 57 aa 44 44 5a 656577555583 7: 7a 7a H4 a5 45 a5 665577555565 76 75 76 4a aa 4 4 @ a 665577555587 3- 3- 3- 3- 3- 3- 3- 656577556509 47 a7 47 a5 45 `5 45 --_~ NUMBER OF PUPS aNnUnMiBER SEX RATIO (MALES) ~ BORN ALIVE 0-4 DAY VIABILITY LacTATTuIDEOXN 665577554412 0o.l5s52 1100007.00 110000..00 1100000.00 665577554483 0012306 1010001000 110000000 1100000000 665577554465 o0l1a38 101000..00 110000700 1100000000 656577554478 0018328 110000.00 110000..00 1100000000 656577550590 - 00113667 110000700 10900..09 110000.00 665577555521 0o3l1a 19020..90 110000000 110000.000 665577555543 00.7310 1100001.00 1100070000 110000000 665577555556 00.5534 110000.00 01000.000 1100007000 656577555587 0.- 75 1005.0 2 100.0 2 100.0 665577556509 00l.6292 110000.000 110000000 110000.700 --~ 298 `Company Sanitized. Does not contain TSCA CBI |. mien --_ ommoesn eG6s37775200412 EEE777333000058 6(3377755244000 GS&5777835550 S668377733355554 C633377755553568 --~ S7733050 enonn e65s77755s00a23x EGG77730444 EE3777553444765 pprrGiiaccsess EE337773555555 Sj7755e857 E337753650 -- DIVIDUAL FUP SURVIVAL: 7, GENERATION Group: vio bose: 500 wo/xa/oay "aE oF LE UPS omy Mave 0-4 DAY vmemIm |wacmroaRzrzon 110100000.000 111000070000.00 211000000...000 110020000000000 101100000770000 111000000000 1110000002000 1100100070000 211000000000000 111000000000 111000000.0000 111000000.00000 101200000070000 11100000010000 111000000000 11000022.00 101000:..00 12000022.00 101007000 1010002000 11000..00 ER oF FROLE FURS BORN ALIVE 0-4 DAY vmemLITY |sacmmbaEzXzon 1100200002.0000 120000.0 1000 110000.00 10000 1100100000000 31100000000 111000000222000 11001000200.000 10100000%00000 111000000000 11001000000000 11500500.00 121000020000700 111000000000 021000000%%000 111000000.000 100: 0 10000 1000.0 1110000:0.000 1011000.00000 121000000.0000 se . 3 `CompanySanitzed. Doos not containTSCA CBI H25231: OneGenerationReproduction StudyinRats DuPont9763 INDIVIDUAL PUP SURVIVAL: F, GENERATION --~ GROUP: VIII-0 DOSE: 3500 MG/KG/DAY NUMBER OF PUPS NaonMoBErR Bory ABLOIRVNE PREDCAUYLLI4NG BODSATYCUL4LING DAY 7 DAY 14 DAY 21 665577556676 12- 12- 12- -8 Z8 8= :8 665577556698 12- 12= 12= e= :5 8: :8 656577557710 1137 1163 315 H8 78 87 75 665577557732 125 125 25 88 88 88 88 665577557745 13- 3= 3- -8 8- =8 -8 665577557767 1123 1132 1123 88 88 85 88 665577557798 12- 5z 7z 7- 7= 7- 7s 665577358810 116 115 115 88 88 88 88 636577558832 1- 1- i- 8- 8- 8- 8: --~ 665577558845 112 11 11 88 58 88 88 NUMBER OF MALE PUPS aNNUDMHBAELR Bom ABLOIRVNE PREDCUALYL4ING POSDTACYU4LLING DAY7 DAY 14 DAY 21 665577556676 -6 5Z Z6 -4 -4 4: 34 656577556689 -5 Z5 5- z5 Z5 5: 25 665577557710 57 57 67 I]3 1a s4 4 665577557732 53 53 53 13 13 33 33 656577557751 SCa 4: a H4 4~ .2 665577557776 55 55 55 s4 44. 34 44 665577557789 3- 2: : 2 2 : 2 2 : 2 | 656577558810 17 17 17 657582 - - - 1a : 4Z1 4-2 ia] 665377558834 47 47 47 43 44 4a 4a 657585 8 8 8 4 a 4 4 || 300 Company Saniized. oes not contain TSCA CBI H25231: OneGeneration Reproduction Study inRats DuPon.9763 INDIVIDUAL PUP SURVIVAL: F; GENERATION ~ GROUP: VITI-0 DOSE: 3500 MG/KG/DAY NUMBER OF FEMALE PUPS Anon BORN ABLOIRVNE PREDCAUYLLI4NG PODSATYCU4LLING DAY? DAY 14 DAY 21 NoMBER 665577556667 :6 :6 -5 4- -4 4- -4 555577556698 -3 =3 3- -3 :3 3Z 23 665577557701 107 7s 78 4 34 3: 3a 665577557732 a5 45 45 a5 a5 a5 :5 665577557758 -5 5- -5 -a -a -4 -4 665577557776 75 7s 75 4a aa 4a aa 665577557798 -s -6 -5 5- 35 : 5 : 5 656577558810 75 74 7a 1 .a 4a aa 665577558832 7- 7- 7- :- 4- :: 4 665577558845 68 67 67 a3 @a 4a e4 --~ NUMBER OF PUPS ANNOTMHBAELR SEX RATIO (MALES) % BORN ALIVE 0-4 DAY VIABILITY LACTA`TDIEOXN 656577556676 0- .50 100-.0 100-.0 100=.0 665577556689 0-.75 100-.0 100-.0 100-.0 656577557710 00.4461 10908.01 91030.080 10807..05 656577557732 0.015268 110000000 1010007000 1000 1000 665577557785 0- 31 100-.0 - 100- 0 10200 | 665577557767 00..5328 120000.00 110000.00 110000.00 665577557789 0-.25 66.7 - . 87.5 100.0 | 665577558810 0o.l5e0s 105030108 110000100 110000000 || 665577558832 0-.50 100~.0 100-.0 100-.0 665577558845 0015373 10901.70 11000000 110000.00 --~ S01 `Company Sanitized. Does not catain TSCA CBI H:25731: OneGenerationReproductionStudyinRats DuPont.9763 ~ aNnUMnBEaR 665577556667 665577556689 665577557701 665577557723 665577557745 665577557767 665577557789 656577558801 665577558823 665577558845 --~ ANnUMaBEnR 665577556667 665577556698 665577557701 656577557723 665577557758 665577557776 665577557798 665577556810 |i 665577558832 || 665577558854 ~~ | | INDIVIDUAL PUP SURVIVAL: F; GENERATION GROUP: VITI-0 DOSE: 3500 MG/KG/DAY NUMBER OF MALE PUPS BORN ALIVE 0-4 DAY VIABILITY LACTTEATxION 100-.0 100-.0 1002.0 100-.0 100-.0 1002.0 110000.00 110000.00 110000.00 11000000 110000000 110000.000 100-.0 100- 0 10-00 110000..00 110000..00 1100000.00 66-.7 100-.0 2 100.0 11000000 1010000000 110000..00 100-.0 100.0 2 100.0 11000000 110000.00 110000.00 NUMBER OF FEMALE PUPS % BORN ALIVE 0-4 DAY VIABILITY rLaTcDTEATXION 100-.0 100-.0 1020.0 100-.0 100-.0 1002.0 1000.00 10808..09 17050..00 11000000 110000.00 11000000 100-.0 - 100-.0 10-00 . 1100007.00 110000.00 110000..00 66-.7 83-.3 2 100.0 10800000 110000.00 1100000000 100-.0 100:.0 100.0 81070.150 110000..00 11000000 02 `Company Saniized. Does not corain TSCA CBI H25231: OneGeneration Reproduction Study in Rats --~ DuPont9763 APPENDIX W INDIVIDUAL PUP WEIGHTS: F; GENERATION --~ | --~ EE Company Sanitized. Does not contain TSCA CBI H:25231: OneGeneration Reproduction StiundRayts DuPont9763 Individual Pup Weights (grams): Fy Generation --~ Lactation Day 0 Group: 11-0 Dose: 0 mg/kg/day Manaimmbaelr Speucp 3 2 03 Es up ms umber 7 8 5 10 ss791 5s 82 sa 73 su asras2 & 67 66 65 7.0 62 64 66 55 as7e3 ? 7611 1631 6640 6660 6670 6630 7633 76.90 62 63 657490 s s6ss 5633 2s0a 68 7s 657455 s 6s 7s 7507 6522 7622 7657 76s8 61 57 65 68 esrsea 8 68 65 6s 65 62 ss7497 & 7.0 7.8 7.6 6s 832 73 64 6s 65 59 69 59 7.2 66 59 1. 657498 75 ss 20 63 73 67 29 esussb 17.20 1e.s3 7732 6614 6752 77.02 76as 77 70 es 65 65 7a ~ 657500 & 7741 7a1s 7714 e7s0 72 13 saz e550 64 53 51 61 71 7. ss1502 s 7663 6s1s 6683 5649 66s7 667a 6a 857503 8? 663s 6557 660s 6643 6623 6771 69 as7508 8611 76.08 68 65 61 60 65 81 5.8 65 6.0 64 5 7.5 657505 s? 666s 6552 7555 6ssa 7634 76.0 ? 55 63 66 65 61 6s 857506 & es 1a 14 74 74 70 73 72 6s 6s 657507 8 6763 6623 6648 67.20 68 63 62 68 65 7a | : e6s5r7s500s8a 5&? 6740 66s8 61.80 67.60 67.34 6639 68 67 6.4 : || 657510 & 77 27 71 70 so mo 7a 7.0 ? ss 74 63 1.0 --_~ ba ONonelpiutptewrasdemliisvseerxeedd.: daca excluded from mean male and female pup weights. 304 - Company Saniized. Doss not contain TSCA CB H.25231:OneGenerationReproduction StuinRdatys DuPont9763 ~~ Individual Pup WLeaicgthattsio(ngrDaamys)0: Fi Generation Grow: 1-0 Dose: 75 mg/kg/day aMnmibmearl zSepx 1 2 3 4 2u5spsnber 1 8 5 10 e756 6601 6600 6653 6612 6537 65 66 65 e117 & 872 77.s0 71.18 773a 77 7.0 80 61 7.5 G58 & 6671 6621 1643 6558 6657 65 64 68 sia g es1s200 8 8751 7851 76.39 s6a5 60 57 16 esmsab 6634 6655 6654 76.20 6638 5699 e122 8 7608 6665 7633 7603 6s em 8 wasa e726 & 760s 77.09 77.50 7621 7155 17156 1637 16 8.9 ~ e125 8 7738 77a5 7725 Ta Ts 4 13 78 e526 & e1as 7727 77ss 12 80 8a e727 & 7517 6630 6538 6634 6652 66.30 1.0 60 63 66 e728 8 6si2a e5.o4 6625 5655 6675 5683 61 58 57 e129 & 6680 668s 6627 68 61 67 66 67 68 68 e730 8 56.30 6665 6525 6556 6671 6610 1519 12 em 6 7s.z4 76s4 83 85 76 83 em 8 10 83 83 73 80 3 es7533 s 77117 7s3s 1700 66s6 17.33 7706 65 7.3 | enc 8 sa 17 8s sz || e735 & 6613 6535 36.08 5556 6631 6623 62 68 64 61 ||| --~ 5a NONooneflpeiumtpatleevraspduepmlsii,svseerxeedd.; data excluded from mean male and female pup weights. 305 `Company Sanitized. Does not contain TSCA Cal H25231: OneGenerationReproduStcudtyiinRoants DuPont9763 Individual Pup Weights (grams): Fy Generation --~ Lactation Day 0 Group: VI-0 Dose: 500 mg/kg/day animal wp Pup Number Mmber Sex 1 2 3 4 se 1s 0s 10 ss7501 s 66 65 73 65 55 53 63 57 60 69 70 51502 71 70 72 62 63 64 63 63 657543 s e6s4 264 607 6674 66s7 67 64 64 61 67 61 64 48 67 657500 s 67 62 65 63 53 55 ssa &? 6585 7611 6630 5698 6608 55 64 63 63 ? 6s 67 67 65 65 68 55 68 657506 & 62 63 62 63 60 60 60 as7547 s 6607 5s5s 7509 5708 5646 7622 5751 6665 66 63 6 657548 s so 87 73 es7549 s 8623 8628 8750 6853 8507 55 67 65 ? 62 64 60 62 657550 & ss 75 so 1s ~ 657851 s 871a 7s6& 18211 6173 76.s8 7.4 7.6 67 63 7.0 67 62 7.0 7.1 es1s52 75 67 1a sa ss553 s &613 7616 6715 6575 6555 76.40 16.44 467 76.59 7. ? 60 66 67 6s arse 7s sz sa 657555 s 8830 7782 6883 78.14 77.54 87.08 78..30 7a 75 71 73 71 70 ssss6 S65 66 64 66 67 60 60 69 essa g? 65 63 ss 63 60 58 67 ss75 sse 2 66 63 60 63 65 . 67 52 56 62 ss7559 5 7sss s7ss so ? 72 75 15 6s 69 12 1.6 657560 62 sa ss3 68 71 66 76 11 6s | 65 60 67 62 | -- so ---- a No litter delivered. | = `Company Sanitized. Does not contain TSCA CBI H25231 One GenerationReprodSutcudtyinRoatns DuPone763 --~ Inaividusl pup wLeaicsthattsio(ngrdaamys)0: 1 Generation Grow: vIzE-o Dose: 3500 ma/kg/day [ Mel aSy 2 a 4 uptuPsbEer EL. sw wm sis seesss 6cso 6esa 6e3z 6eax 7s3s [EE : ere FHcFa 63 63 62 62 53 63 6s es [ER : am 8 eeos esas s6as s6a1 6es7 esso 5e9s ea ss Grn e8 siso eeod sese esss essa eesr ae wisi 8 aslas 06 eess es 1a es ea es 62 erm eeers 1e4b 6e2r eesa es -_ sesma :8@ Eeda eens eean ceod es 61 ez ez eo es a1a6 easd anaa rsaa 47s aa 12 7a arm scla 6cas eees eess sees 62 ee ses oe wns Ssaa sosls sa ae sa oss eas 8 esna sehe asss a6a4 es 61 eo 8 60 67 70 sso esao s6aa sess s0e eedo seoa ssos amas a Gre e s7s0 c6as e7a0 . 6es1 e6e3 6e3s 7saa ' || ase 8eere 1cae 1eae e6s2 6s 6s es || ses 8 sslss eeas aera eeoo eess 6e1s ee es | ||~ rTeem tieeeeeredeeetteveereed eee = Company Sanitized. Doss not contain TSCA CBI H:25231: One-Generation Reproduction StuindRayts DuPont-9763 --~ Individual Pup Weights (grams): Fy Generation tactation Day 4 Preculling Group: 11-0 Dose: 0 mg/kg/day Animal mmber Pup Sex 3 2 3 Pup umber 4561 8 s 10 657491 & 15.0 151 ? 14.0 145 657492 ? 9.6 9.9 118 102 8.5 20.2 9.2 5.4 5.4 12.0 0.2 117 8.3 9.2 10.7 111 95 116 657493 105 10.8 109 10.9 8.3 11.7 11.1 1.6 ? 105 8a 101 6s7498 & 9.2 103 118 10.4 0.4 6s7ass ? 107 88 9.0 9.5 9.9 5.9 123 10 122 12.7 103 11.8 89 9.1 10.3 10.0 esrag6a ? sa 10 12 113 12 657497 103 57 13.0 10.4 20.2 111 11.6 657498 2 9.9 12.8 1.4 11.8 9.8 10.8 5.4 10.0 9.2 12.7 11.2 10.4 9.9 10s 10.5 9.5 657499 ? 106 114 1.2 114 10.1 12.0 10.6 33 114 11.4 11.1 10.5 12.6 10.9 10.9 657500 ? 123 116 1.6 115 115 10.6 12.4 12.0 12.0 127 1.7 ~~ ? Ile 12 123 11 1.6 657501 & 10.4 10.8 110 10.3 10.9 10.8 657502 ? 9.8 104 97 9.9 107 10.3 10.2 115 0.9 55 9.3 83 10.7 657503 2 & 101 109 10.3 111 20.7 53 11.3 1s 10.0 10.7 10.8 10.4 10.5 657508 ? 9.8 10.1 9.9 111 5.0 10.6 10.6 $133 107 122 1.6 19 105 119 111 12.3 657505 ? 116 12.1 11.0 8.5 11.6 10.2 114 113 10.6 10.9 10.3 11.9 657506 ? 10.2 103 1.4 16 1.2 1.9 103 9.8 1.6 12.3 118 12.2 657507 103 1a 1a 11.0 116 101 5.8 9.6 113 115 103 11.3 10.6 657508 L209 102 103 10.4 17 12.0 123 12a ma 13 . ss7s098 ? 117 207 116 11.0 12.0 103 10.6 11.5 12.3 657510 100 14 11 97 14 5.9 20.3 16 ? s2 10.8 5.6 10.2 |~ | | -------- a No litter delivered. 308 Company Sanitized. Does not contain TSCA CBI H25231 OneGenero Reproduction Sy in Ras Duron 763 - Individual LaucptaWteiiognhtbsay (4szPamrse)c:ulliPn1gGeneration Group: 10-0 Dose: 75 morkosday AnR imal Pup E 0. E WESabEer , sie en 68 aiounesl dmieas 1ww0sa0 0dsoee ldaoodsd 1 as ma 1a a0 s1 0s ems 5$oYWoes 1GW0Esa wowaehaoSW ss mo we ss aarmses:8 we ws 1s mm S6 ONdDa WdoLs EloDa mdoas iowse mdoss 1o0mse ows em CFhSdlee iisa m3aaoduae ie ws mab 5 inbhns te: me ma ten me ise as es meso Ddlha mmbi mmaa mw4s msoe bmaa a10 ws ~~ me em 5?oa1ns2na.es9 m1md2oa3ean1h5a3a me tes wo os 10 105 as ane 0s 102 mm 3 dllookooasadak wdaoahs sNshEn adOoNeYs aiioans ss wa se sm emo 8G lodOVweE wd2oh7e w1V0os3 de ws sa se ie 5s ds ms es os 103 sa mn 5Coashlak doWagnENiTe aSwnoe ue 1s a . ein eis 85 mhnaohs oimsa mmae mbee we ae ; ame :5 aOND iLoD diese ameas nh ws ws me sss Goewoe asa wNSo sosm lVeamna ss se ws |[| ~ 5TFoonpoontriatwvieeotesnrn dSaonitasia.vveerresde.ntiy culled and weighed on Dey 6; data excluded from stacissical || -- | ww Company Saniized. Doesnot contain TSCA CBI 25231: OneGenerationReproductionStudyinRats DuPont9763 ~ Individual LaPcutpatWieoinghtDsay (4grPamrse)c:ullFi1ngGeneration Group: VI-0 Dose: 500 ma/ka/day aMnmibmearl Smeaxp 1 2 3 4 Eu5sp ush6er 1 8 5 30 emai & 11200 1m4s 110202 190.48 121 106 117 esiz s 110003 150.41 10057 1100047 110a4 10.5 107 10.9 esses 8 a95o 1120 120a l10s5 10020 83 9.4 1s 108 e7saa & Ssls49s8s 9.6 10.4 89 10.6 9.8 89 10.0 101 5.6 5.8 9.5 e745 & 1122as 1102.15 1110s3 1809.7 19192 9.8 12.6 121 e146 & 8.5 sa 9s2e 1m0a5 19041 110.21 s8a3 1903.5 sa erse7 6 1s0.s4 2100.38 10.4 10.8 106 10.7 10.4 ia 103 e148 1156.11 1155538 1165.39 165 1.8 e369 110:63 1152 110.04 110..49 100 1.6 12 17 ~ e550 ? 13.7 mle 142 1s 13 le 15.0 1a 13.6 12.9 esnss1 & 11000018 110.2 110025 1101018 1101.8 10.6 10.8 esmssz 8 1a2l5s 1l0.e6 1m1.40 1112.16 1a 20 98 89 12.3 e1ss2 & 0u0l6 1100039 1913 1100003 12.0 11.0 10.4 10.5 10.6 10.8 esse & 1m6l4 1b40h.0 110.26 14a Ba 120 13.3 ess on;1205 112s7 112a0 1137a 110203 B12a5 12.2 e556 9s.i6s o9s3 1982 190..23 180.63 99.76 180.3a 98 | essa @ | . e7sse 8 155B 110.09 1100.06 115 9.4 9.7 ILI 116 8.3 e159 & 115.70 1m3l.s4 13 1 Bo BI 12 e760 & 1943 1120.60 M5.45 1110..07 14 10.4 10.5 33 10.4 ~~ mmatso Litter delivered. 310 `Company Sanitized. Does not contain TSCA CBI H25231: One-Generation Reproduction Study inRats DuPont9763 --~ Individual LaPcutpatWieoinghtDsay (4graPmrse)c:ulliFnigGeneration Group: VIII-0 Dose: 3500 mg/kg/day hMauibmearl Pup Sex 1 a sa Pup Number ss 1 5 5 10 om ssises 10.9 0 1110.003 0100.63 islse 01139 1101..21 ssisera esses 8 & 124 10.4 0.2 11.6 10.2 111 116 112 107 1s es 1.0 srsesn 8 e750 8 7.6 ms 87 9.6 97 7.8 88 sss 8 1e0s4 1e0s.1 5m.s6 180.32 1T0a.6 180.53 9.0 83 ess 8 9 1e3s.2 123 1s2s.9 102 1ss8 127 104 as 0.5 m2 93 m2 56 123 10.2 107 e773 & e 1.0 a0 12 m2 LS na 114 ua 12.2 esse sa si 84 sa 9.2 93 9.9 92 82 93 5.6 87 83 --_ esiise 82 esse & 133 1s 122 127 129 1.6 122 16 19 13a B22 BO 127 ess & 9. ss 92 ss 9.6 10.0 9.6 80 9.4 97 9.0 83 esrsrsa & e779 esiss0 8 10.4 0.4 9.7 9.5 & 8.6 8.8 1s0.40 190..27 45.49 87 84 85 91 86 85 e581 8 er sa 82 ms 83 7.7 sa 9.4 87 92 8.8 sa sa 75 83 me 85 Ta ssisa 8 | e783 4 9 9.6 0. 03 9a ss 96 1307.4 190..94 98..88 190.52 : | | esse 18 105 11.3 we 1100.78 19a3 2 los 111 e785 4 9.1 5.4 9.4 100 9.8 8.8 9.8 9.2 | s7 se 52 93 sa 88 --~ p 2eNeo li-- tter de-- livered-- . r------------------ En iSeries Company Sanitized. Does not contain TSCA CBI 425231OneGeneon ReproSins Dresses ~ vidualL7aotateiiognhoisy (4grsaesmam)e:sii#i1ogGeneration PO, soses 0sarkarday mJs m-oo, sp mmen er | wn wus 5DoOaMnmEo wa N se wes ass anise So $Ov koRS IABwwEow EwEL wAwe aw Pow Er Ew : ase P$ $om nmnowaomheoEmw alwaow f-- ~~ -- ans anaes anne $n msm ow P$ooommk1oi1ny.l8oom1aoS s.h2 nEow1m 2.3 wow ww1.1 o$ $kv na Eoonm noAa wn ows $m omou ws wn; son J $ :$om nmoomomws o&wdoam ||| aso $?0 owme oomwa ans ommo PS To er atv eee mim geoa en | Camps Santas, DossnotinTSCA GB $i25231: One-Generation Reproduction StudyinRats DuPont9763 --~ IndividualLaPcutpatWieoinghDtasy (4grPaomsst)c:ullFi)ngGeneration Group: 1-0 Dose: 75 ma/ka/day Taunbimearl wSpe 1 2 3Pup NumberA s s 657516 3 n10.s4 110.16 n13a n5.a8 51517 s n9.s5 1100..08 85..49 150..79 assis s 150..02 1fr0ee6s 102..40 01.s7 essisa es520 h 10.6 12.4 21023 B13es 13 ns es1s21 s 010..88 1100.33 n10s7 1100..92 57522 s 1123..06 1123..21 12216 2120.a3 e723 h] nnas esrs200 3 1120.30 106.12 1102..56 155..62 es7s25 s 1120s3 21.24s 112.34 12.0 2a ~ esn526 52 u12es 21.11 m12.20 12.8 15.0 7527 1100.6 00..18 150..15 n9.e1 657528 00..30 80..61 55.19 110..4 es7529 hi 190..53 1010..00 I5.]5 10.0 10.2 657530 s 190..57 88..57 55..90 09..95 e731 h 1103.24 3 1.7 ws 1.0 11.2 12.8 e732 h 11222 13 12.4 13s e753 s 12.7 12s ns ne . e730 101.592 1n7e 1160..68 1r6e as7535 5.8 10.0 5.8 10.6 po 0.2 sua 0.2 3aoPupsJitwteerre dienlaidvveerretde.ntly culled and weighed on day 6; data excluded from statistical ~ eoanfaelmyaslies.pups. ee 30 e Company Sanilized. Does not contain TSCA CBI H25231: One-Generaton Reproduction Study in Rats DuPont 9763 Individual Pup Weights (grams): Fi Generation --~ Lactation Day 4 Postculling Group: VI-0 Dose: 500 mg/kg/day ANnuimmbaelr sPeuxp. 1 2 3up Number4 5 5 657541 es1sa2 es7sa3 ss15a0 ss754s 651546 657547 ss1sas 651548 ~ 657550 657551 657552 657553 657550 ss1555 657556 ss75578 || ss1sse | 851559 657560 8 rey 10 10.0 1s 152..42 02..18 5 0. 007 0.1 0.5 0.5 0. 10.9 0.4 3 9.9 uo 0.1 0.2 ne 85 10.7 10.8 5 0.4 10.6 9.8 10.1 se 56 0.0 0.8 8 10.5 12s ns 21 8s 5 n.2 9.5 s 8.5 5:8 105 9. as 10.2 10.5 0.3 3 10. 10.8 10.8 0.6 10.7 10.4 5 195..51 105..35 16.9 3 u160s1 11500.8 101.503 16n.z5 15.8 8 1103.76 frneezs 10 137 10.5 1500 1s 3 10.8 51 02 01.356 n12as 8 1120..51 00..68 10.8 a0 1005 ns 5 1210:.08 1n2.o1 10l.s0 5.8 10.5 3 113s 10.3 00 5.3 10.6 101 3 1103s 110.12 14100 1132..12 15.9 8 u1n2.9 02.73 152..63 12s 5.7 0.5 5.8 5:2 10.3 3 32 10.9 10.6 ns EX] ns 5 9.5 15.0 0.8 1a 10.0 137 1B 133 1 13.0 15. 5 na 5.3 lo 06 n5.a9 n10o.5 --~ -- Yo litter delivered. 3 Company Santtized. Does rot contain TSCA CBI 125231: One-Generaton Reproduction Study in Rats DuPont 9763 --~ IndividualLaPcutpatWieoinghDtasy (4grPaomsst)o:ulli)ngGeneration Group: VITI-0 Dose: 3500 mg/ka/day Raunnibmoarl seuxp : 2 Pup u3nber . s es7s66 s 110..03 1100..36 n9.s8 01.32 asrs6ra s esass 5 110s.4 n0..56 n10.l2 ne 12 estsesa s2 as7570 5 76.36 6s.s6 89.37 o7.s8 575m : 5s.i9e 08..92 100..56 100..33 ss1872 13.2 2.7 1s ns 1n2e 2.3 10.7 657573 1m00 1n2z nnss p1r2es asr578 o0.n1 5:24 89.22 59..39 ~ esrsnse es7576 s 1n3.s3 1122..72 112.62 113527 e557 o5.s2 1px0.0 B5.e6 59.34 ssrs7ea as7575 10.4 10.4 5.7 5.9 10.0 10.7 9.9 67580 hi o7s 86..28 0a3a o6u.s arse s5.i7 7o5s 76.33 7s4z ss1seza 657583 2 5.6 0.3; 5.1 5.5 : ss1504 u10s.8 a[xs] 150.68 15..74 esses 32 05..18 00..70 15.28 180..89 | 0.7 9.2 03 as | | ~~ a--Mo--li-- tter--de-- liv-- ere-- d -- 35 Company Sanitized. Does not contain TSCA CBI H25231: OneGenerationReproductionStudyinRats Dupont $763 ~ Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation Group: 11-0 Dose: 0 mg/kg/day Saunribmearl snepx 3 2 up u5mber a s ssr491 ssra92 e749 ssrass ss7095 esrasea ars as7a98 e579 ss7500 ~ ssrs01 ss7s02 as1503 ss7504 ss7505 657506 ss7507 ss7508 ss7s09a ss7520 s nnoe m18s0 s i1sss 11640 m16aa w11s4 w1a3 amae 116a2 es 163 s w1s7 1166s 1a822 1166ss Wwas wvas w19aa w1oa s wma2 we wma an s a ma 1w6e0 aasss 110a7 : 1wss 1p9a6 amsas 210s2 h] 3 ws 1wmaa a9eas 11ss s az 12 1m6s6 a1e9sa 118a0 s a iso eass aaesss s16a2 s ae so wmeo 1a6e0s 11sa wa2a w1ea 2m0s1 a1uss 2 wwaae a1eas 1ae3s 118600 s 1 ws easza 1w5a 11600 16s s amsoe ameos m1as 1s. 3g wwoa wmaa wm5s w18a0 2 7 16s asa asa 5 s ms is a1sao 1m6a0 1m5a3 |i vo Litter delivered. | { | 36 `Company Sanitized. Doss not contain TSCA CBI H25231:OneGenerationReproductionStudy inRats DuPon9763 ~ Individual Pup WLeaicgthattsio(ngrDaamys)7: Fi Generation Group: 1-0 Dose: 75 ma/ka/day Raunnibmearl sneox 2 2 5up dumber4 s 5 es7516 e717 es7s18 ss7s108 657520 ssrs21 sss ss7s23 es7s200 es7525 ~~ 657526 es7527 es7s28 ss7s20 657530 sss es753.2 657533 || esrs3ee | 657535 f 18.0 1. 161..54 m1.16 11.5a p 161.09a 1155.64 1107..96 10506 5 21060.13 191.s0 1168:.62 wmaa 5 s 220..97 12..6 128.s2 2.2 19.5 s 1106.39 116s.2 11ss 116073 1108038 11.001 8 193 1192.5 10 1186050 19.3 15. 15.4 1n9.s2 1m9.s3 1186.69 1183 18.5 % 117..46 119..25 1 20.0 1.7 19.4 p 11s fmns 1.3a 1.9 h 1156069 1.205 m16i.9 1156..01 s w15a09 115.52 14150.92 1166..28 16.4 h 1668 1105..78 2168.9 15.9 2a001s 13.023 2150.53 2105..86 pe na h 120s1 207 1159038 2019..24 1m876. 119.009 s 2103s 2160.02 211s 22031 3 015s.9 161.563 1156..96 1157..47 3a HPoupsliwtotreer dienlaidvveerretde.ntly culled and weighed on day 6; data excluded from statistical --~ Xoanfaeimyasilse.pups. | 30 Company Sanitzed. Dos not canta TSCA Cal H25231:OneGeneration Reproduction Study in Rats DuPon9763 ~ Individual Pup WLeaicgthattsio(ngrDaamys)7: F) Generation Group: VI-0 Dose: 500 mg/kg/day aRanmnbae)r suepx 3 2 P3up Number 4 5 5 es75a1 es1502 e756 es7500 es1505 e756 es7547 657548 e709 es7550 rr 657581 esrss2 es7553 e755 657555 ass esrss7a e558 ers es7560 s 1158..27 1168.39 160..34 111..66 5 18.0 4 15.4 7.3 116697 1166.16 5 113861 1166..70 E15n.9 116s1 5 16.6 163 1176..59 1136s2 1156..65 8 168.4 151.943 1 16.1 119.90 . 15.6 16.1 me 16.8 115..89 715..46 1166.50 165205 16.4 16.5 16.6 16.7 22078 2201 220s0 2 2.8 118.s3 16.5 1.0 17.5 1.4 17.5 163 221.a0 22.03 220096 221.000 11.. 116.22 115..08 1266.79 1818..00 1187.57 1158..76 116078 18.9 1.3 ls 1.0 1104..09 210..25 201.628 22007 220.a6 2a 20.7 5 2.2 15.4 1nl.s8 2190.05 21090.43 s 162.2 51.89 165..42 176..32 s . s 1165.22 176s4 61..09 1.7 1.9 : p 22110006 2200s4 20.0 213 20.6 20.8 hi 151073.9 11.s6 7.74 61621 ~ r0 l-- itter-- deliv-- ered.-- || || Ey `Company Sanitized. Doesnotcontain TSCA CBI H2521: OneGeneration ReproductionStudyinRats Dupont9763 ~ Individual Pup WLeaicgthattsio(ngrDaamys)7: Fy Generation Group: VIIIT-0 Dose: 3500 mg/kg/day RAonnibmearl prHp 2 2 Pup u5mber . s as7366 s wvsa me0s 1wsa 1w6a2 as75672 e736 s nwsa m16a3 116643 13 18 es7s692 h as7570 s 1n3.a3 152.2 05..84 151..10 srs h mwae 116as 11664a 166 as7572 s 1me6 a20s2s 1209032 mo 1s as7s73 s 1 wa 1assa amsse 11563a as757 s B1aa pwaa w12sa w12os --~ asrs750 :s 657576 s w1s5 1227 amses 119s3 ssr577 s wwsz 1121s 1120. w16ss ss7s788 : e757 swas i4e3s 16 ws Ba ss7580 s w2s3 aoos) mwes 11202s ss7s01 s wBsa wmso aa0s a 123 es75628 e783 . 5 s2 FE AE.) as7s04 s wnlas w16b3 m1623 11821 i asses 1wss a1s0o m1638 116679 | 125 13 1s 169 ~ svo tm iterr deliv-- ered.-- 35 Company Sanitized. Doesnot contain TSCA CBI 25231: OneGeneration ReprodSutucdtyiinRoatns DuPont9763 Individual Pup Weights (grams): Fy Generation ~~ Lactation Day 14 Group: 11-0 Dose: 0 mg/kg/day HAniimmbaelr SPeuxp 2 2 Pup N3umber s 5 5701 3 38.6 36.8 33560.45 asras2 5 ao 33 38.8 36.5 35.4 38.4 38.2 0s 657493 5 335:s3 3346..02 230070 35.7 36.5 ss7450 5 3u5s.5 33520.50 3356..06 335.. as7495 5 3801 3.7 37.0 3.9 0.2 381 39.7 30.4 ss7asee 5 657497 5 39.5 35.8 3.2 36.5 36.6 33 38.6 35.9 657458 25 3398..12 3379..01 3375..08 3397.63 657499 8 0.0 37.9 38.2 38.5 39.0 38.5 3.7 36.6 --~ 657500 5 338..90 3835.008 a38.84 39.5 35.5 657501 8H 336..93 u38.s3 3350.71 3355..24 ss7502 5 3:2 a3 36.8 305 303 3501 35.1 36.4 657503 8 332.2 3358..87 383..32 31.9 3505 ss7500 5 6.0 aa alo 38.7 als 37.8 0.8 39.3 657505 5 3365..07 337..73 3348..79 36.5 3504 657506 5 33 31 36.6 348 3352.004 37 FE . 657507 3 3.7 36.6 38.0 3606 38.9 37.0 39.2 31 ss1508 5 a7 0.8 0.8 0.3 3a8s.8 39a.s7 : 6575098 8 657510 3 3.9 36.7 3.0 30.3 216 39 34.3 30.5 --~ avNowlTittrer rdelriversed.m-- | | | 320 `Company Santized. Does not contain TSCA CBI H25231: OveGeneration ReproductionStudyinRats DuPont9763 - Individual Pup LWeaicgthattsion(gDraamys)1:4 Fy Generation Group: IV-0 Dose: 75 mg/kg/day Hunmibnear sPeupx 1 2 5Pup Number+ 5 5 657516 5 38.1 36.2 36.4 36.1 36.3 3.2 36.0 345 657517 5 26 30.7 30.4 3100 2001 28.1 30.7 28.7 es1s18 5 ars 340 0.1 360 39.5 35.5 3s 36.2 es75198 3 657520 5 as ae as es7521 5 393.20 3394..82 363.206 336.80 31.6 657522 5 3.5 2100 3503 26 2630..22 2337030 657523 5 255 26.1 206 25.1 ao 657520 5 as a 35.3 30.3 38.4 657525 3 3386..24 7 36.6 as 3.8 29.7 38 35.0 ~~ 657526 s 330.79 36.5 351 3.5 3.9 3.5 0s 657527 8 341 3901 3s 38.9 338..21 38.0 651528 8 3306..67 3346..22 38.9 BE 3s. 32.0 657529 8 341 35.8 34 2s 3.4 34.6 3360.82 35.0 657530 H 3 32.2 3:2 sz 3.6 3336s an. 657531 5 3338..4 2.97 3393.030 3380..58 38.5 a7 i 38.5 36.6 es7532 3 35:2 ea 36.9 38.9 38.3 es7533 5 3a50s9 33.965 335..64 336.s5 - 657534 3 asi as als ae 657535 3 3.2 a3 37.0 35.8 | a8 36 3s 31 || ~~ 5a PNuoapnslaitvtyetsreiers.dienlaidvveerretde.ntly culled and weighed on day ; data excluded from statistical No feat pups. | | 21 CompanySanitized. Donotecontsain TSCACBI 125231;OneGeneration Reproduction Study inRats Dupos763 --~ Individual Pup WLeaicgthattsion(gDraamys)1:4 Fi Generation Grow: vi-o Dose: 500 marka/day Saanbimeatl ro52 : 2 sEup umber; s . asa esa essen esnses asses essa essen esses esnses esnsso ~~ esnss ssa esr: asa esnsss asnsse esaissra esis aasss essen s e asWe wowas mmas mmao se omSaeo : Bs awmas ms aamns ome owmea s em as s amsa mmaa eeao i: sRear esa wwmaa ss aowes wi wwse ma s ea me a i Rs swss ows mmas ml mnao we oma ome s ea ak s oamha ses eBks wwkh amlhs wmas ws s wsis wamee amwse aalss s ? sa sa7 4ao1sm.ae0 4am0l.ee6 4as1a.a8 &esiws omwoe oamse aaes s esee eesa wana maen &esiwe sso mseas ae awmna wa amea ma e esae aassaa aaweas owmaa ews mz as ame 52 sSese mase aawsa . ma wo Swews awsi smo wo aa aa : Ewso sWeea eahe ammko ~~ -- Te tierer dette. = CompanySanitized.Does notconlin TSCA CBI H25231: One-Generation Reproduction StudyinRats Dupont9763 --~ Individusl Pup WLeaicgthattsion(gDraamys)1:4 Fy Generation Group: VIII-0 Dose: 3500 mg/kg/day Raonnibear rsex 2 2 Fup u5mber s s esse asrsere asses ssrs69a sss70 ss7s71 ss7s72 as7573 e757 ~ asrs750 es1376 ss7s77 ssrs180 ss7579 e700 essen | essen | as7503 || as7584 | || ss7ses s ma mo 3 ss woss m340 s s mo 2 ma m2 na s ao ws 0 s ms wo me 20a s ms 2a aosmsa m1s0 2ass s 2 ne a377 a 2s s ma me omsss 2a9mso wasas m0 s mmas m22s maeas 226530 mis asa sa 2s 5: s mo ns mms2s m0a0 m2oa s aa 22 wmss 2mss 2064 5 s owmss 2m9a3 28 ss 20 s aswss 2ms6 22632 220013 s ma me mwas 2233 2236 5 . s 2 3 2a9m5s a0e3s m21as s asa0 wmsa 0030 0m22 mmssss 2m3a sseas 2ma --~ FE 0 1itter delivered.-- Ex] Company Saniized. Does not contain TSCA CBI F-25231: One-Generation Reproduction StudyinRats DuPont9763 --~ Individual Pup Weights (grams): Lactation Day 21 Fy Generation Group: 11-0 Dose: 0 mg/kg/day HAunmibmearl suepx 2 2 fun 3 ber . 5 as7s1 ssras2 657493 657490 asass. ssrasea 857497 657498 657499 657500 ~~ 857501 ss7502 657503 657500 657505 657508 657507 857508 ss75098 | 657510 8 57.9 56.5 1.6 57.9 5 ss.2 52 66.9 ss. a.7 57.8 55.6 511 3 55.33 5589..35 as8s.s5 56.7 51.8 5 55.9 56.0 59.5 55.9 a2 58.6 56.1 50.3 5 a8 60.3 6a. 518 os sas 60.3 59.5 : 5 6501..69 80..10 63.9 58.7 62.9 60.1 3 sz as 62.8 ey 613 56.8 56.0 55.2 5 as a0 6.9 59.6 62.6 62.5 a5 59.2 3 0.7 59.3 a3 s6.8 63.4 s6.5 6.3 59.0 8 158..90 51.7 50. 51.6 5.8 56.6 56.5 3 60.4 50.7 53.1 se. 5303 59.0 52.5 sas 5 5s5.e0 55130.09 6.1 58.6 s0.a 3.2 5 6.7 0.2 56.5 61 15 0.1 9.6 50.0 5 0s2e.s5 856..00 a 50.5 56.2 51.0 5 s55i.s2 5$11..16 5512..39 55.9 58.6 5 60.5 8.3 58.0 ssa 8.1 sez | s561..12 8 600..16 6e5.a1 62.7 62.6 66.5 6.6 5 8 as 0s sa.1 55.8 asa 55.7 56.3 sie | | | --~ ao litter delivered. | eee ---- ED= compr Sie eeverrlA--C--H-- 1025781One enrtionReprdScoyiionns Dure763 --~ Sndivicust Pup HTeaiegthattsion(gpraayns2)1: Fi Generation crows 70-0 nese: 75 ma/k/day meow Animal Pup . JonMaossbe,r s . cme --_ T&: oemss wamnbs o8 snaa 6swsna ame H $En rS oowsrouswn ow as JE a C : n es nmo eale ee ea cn [. PoooooomambnnooooonwahrnoosoB nnnoW oaas J. PooomaE nr ww we fi 3S oaoersa wsBar aroeaan wa wl as ~~ -- fo. ST2 ooow8w5r5.8 60Eam .Ls0 BBa55Ln.6 es aa wa | ws f E oom RnEoas un os=omowwmm cms Sony RL BLRE see ws aEoDm nnm owun mou Xsse wn wren P {Sao Zrwaow BLE es ms . $8 ar ws as we 657533 :33oo w64e.5 m 6B 0.9 IW66.1 6oo2.wm9 - an T! senonsa mosn owme ~ B3 TolneTeMep phtopeerwodaenmlemleende.tyrnaewainads.and on day 6 daca anciuded frm sacistical SS re, = CompanySantzed.Doss notcontainTSCAGE! 125231: OneGenerion eprodscton SyinRats Dupon763 -- Individual Pup LWeaicgthattsion(gpraayms)2:1 1 Generation Grow: vE-0 Dose: 500 ma/ka/day faoieoes io.d : : 4pup NumberX . . essa assez esses asset ess esr essen essa esses ~ ras--so cana ass esse esnsss cans essa e wsma mseas mwas wsmm FGeeEsms Go ses soemsa saees P$o0 BNoe Ba Bmsa ms womsa oma wass sa G0 mGea Pe =aamas ssess wh mwsa aa T RLmi Bwso wmna saknhs sme ss P : anSe : Gs mwos ms mmess ma ea P asSs Po we wwra ms momna oma sseas ws I mwae mesa swsa mooa P REBa Sse wmae mls oswess aes =seon sez FE Bs sss eise eamae ms i$7Gr eeab aebs aasa ss Po mSeh Ss maki He mwes oma ossss oso 657558 esnsss e. D8 oa4wn9.h4 55aE.ue9 as54.6 54.6 512 | esse P:o sGsa wGs4 amss ssse wma as : 5 wa ws sa || m Te tivem s detivem red | || % ompany Sanitzed.Doss notcontain TSCACal H25231: OneGeneration ReprodSutucdtyiin oRants Dupont 9763 ~ Individual Pup WLeaicgthattsion(gDraayms)2:1 Fy Generation Group: VITT-0 Dose: 3500 ma/ka/day TAanipmearl es7366 asrsere ase asrsese asrs70 esrm rm ass arse --~ asrsase ss1576 asm ssrsmaa ams ss7580 essen amsane . arse sss arses | PB up a 2 up 5Number s s 5Ss mows aasoa asess aas0o : Pas ae sma ma ese we wo as i ma Sao oammas oommaa wmso i5 5 mwsa oss ossmss osws sms wo ms iemawh emo ssees owls swesz en aess ssa ea GSomaa oammes aess awaa s$ 5i i osmesa ws sssmsa ea ossns es emao al :oes ass wa ar s ees Sows wwasn wa wo wa i5 i amlss wma eamns sa asssa wn a3sa ma Sms ame ws ses 2sass ema waaa . oewssa aazs i ow m 5 wi aossas wo swise as saoess as ewe as ao wo . || , eho ctitrm es ce--tive-- red. -- eevee | {Eplz ------------t Company Sanitized. Does not conTtSaCAiCBnI F-25231: One-Generation Reproduction Study in Rats --~ DuPont9763 APPENDIX X INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F; GENERATION --~ 3 | Company Sanitized.Does not contain TSCA CBI | 125231:OneGenerton Reproduction Study in Rats Dupon9763 ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: ?, GENERATION GROUP: 11-0 DOSE: 0 MG/KG/DAY EwRs actDAiYon INsCtIaDnENCE OBSERVATIONS 657491 NO ABORYALITIES DETECTED 657452 No ABNORMLITIES DETECTED 657493 NO ABNORVALITIES DETECTED 57494 NO ABNORVALITIES DETECTED 657495 NO ABNORMALITIES DETECTED 57437 No ABNORLITIES DETECTED G57498 NO ABNORMALITIES DETECTED 657499 NO ABNORMALITIES DETECTED 657500 NO ABNORYALITIES DETECTED 657501 NO ABNORMALITIES DETECTED 57502 NO ABNORMLITIES DETECTED s7503 wo AmvomMALITIES DETECTED 657504 NO ABNORYALITIES DETECTED 657505 NO ABORLITIES DETECTED 657506 NO ABNORVALITIES DETECTED 657507 NO ABNORYALITIES DETECTED 657508 NO ABNORVALITIES DETECTED 657510 NO ABNORVALITIES DETECTED --~ | 329 Company Sanitzad. Doss not contain TSCA CBI H25231: OneGenerationReproduction StiunRdatys DuPont 9763 --~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F; GENERATION GROUP: IV-0 DOSE: 75 MG/KG/DAY ANIMAL NOMBER LACTDAAYTION DIsC1IoDvENCE OBSERVATIONS - a 657516 NO ABNORMALITIES DETECTED 657517 NO ABNORMALITIES DETECTED 657518 NO ABNORMALITIES DETECTED 657520 NO ABNORMALITIES DETECTED 657521 NO ABNORMALITIES DETECTED 657522 NO ABNORMALITIES DETECTED 657523 NO ABNORMALITIES DETECTED 657524 NO ABNORMALITIES DETECTED 657525 NO ABNORMALITIES DETECTED 657526 NO ABNORMALITIES DETECTED 657527 NO ABNORMALITIES DETECTED ~ 657528 NO ABNORMALITIES DETECTED 657529 NO ABNORMALITIES DETECTED 657530 NO ABNORMALITIES DETECTED 657531 NO ABNORMALITIES DETECTED 657532 NO ABNORMALITIES DETECTED 657533 NO ABNORMALITIES DETECTED 657534 NO ABNORMALITIES DETECTED 657535 NO ABNORMALITIES DETECTED |~ || Company Sanitized. Donotecontsain TSCACBI mn EEpe ~ 657552 NOABNORMALITIES DETECTED H25231:OneGeneration Reproduction Study in Rats DuPont9763 ~ INDIVIDUAL LITTER CLINICAL OBSERVATIONS: F, GENERATION GROUP: VIII-0 DOSE: 3500 MG/KG/DAY AWNNIEMEARL LACTDAATYION INSCIIGDNENCE OBSERVATIONS 657566 NO ABNORMALITIES DETECTED 657568 NO ABNORMALITIES DETECTED 657570 NO ABNORMALITIES DETECTED 657571 NO ABNORMALITIES DETECTED 657572 NO ABNORMALITIES DETECTED 657573 NO ABNORMALITIES DETECTED 657574 NO ABNORMALITIES DETECTED 657576 NO ABNORMALITIES DEFECTED 657577 NO ABNORMALITIES DETECTED 657579 DDaAyY 07 1100OFF87 SSOURBECURTAINGEHOTUSREAHREMOLERGR(HSA)GE RIGHT REAR LEG(S) --_ DAY 14 11I00OOOPFF777 DSROIIRGSEHCTHRARIREGGAHERTRIPRGEAHAWTRMLIRESEGSA(IRSN)GLEG(S) 657580 DDAAYY 714 lToorres SSHMAALLLL WWHHOOLLEE BBoODDYY 657581 NO ABNORMALITIES DETECTED 657583 NO ABNORMALITIES DETECTED 657584 NO ABNORMALITIES DETECTED 657585 NO ABNORMALITIES DETECTED | = Company Sanitized. Does not contain TSCA CBI | 2551 OoGatos ns omens ~ APPENDIX Y INDIVIDUAL BODY WEIGHTS OF F; MALE AND FEMALE RATS ~ | | | [~ |! | Company Sanitized. Does not conta' TSCA CBI | 125231: One-Generton Reproduction Study in Rats Dupont763 py INDIBV ODI YWED IGU HTSA OFL F;MALE ANDFEMARL ATES EXPLANATORY NOTES Abbreviations SD = Sacrificed by design FD = Founddead --~ | FE | EE Company Sanitized. Does not contain TSCA CBI H25231: One-GenerationReproductionStudy inRats DuPont9763 ~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS Grove: 1-1 DOSE: 0 MG/KG/DAY oDNATYESST: 1 8 15 22 29 36 ANIMAL NO. 666600557754 S615.66 10982..15 115619..68 220450..58 236050..06 336254..79 SSDD ((DDAAYY 4400)) 666600557776 S576018 110010..76 115662..85 221227..09 2279131.37 338304.58 SSDD ((DDAAYY 4400)) 666600557789 6603.033 10925..78 115683..23 222281153 227936..90 3337301.98 SSDD ((DDAAYY 4400)) 666600558801 660382 S66206 10973..95 114792.18 2240891.35 322660..42 430237..22 SSDD ((DDAAYY 4400)) 6303 115.8 1813 241.0 3115 373.4 SD (DAY 40) 666600558834 5S26065 8964..48 114422..96 119965.17 224541..23 231933196 SSDD ((DDAAYY 4400)) 666600558865 6690..46 111056..32 118721..77 225373..94 334010..94 433687..39 SSDD ((DDAAYY 4400)) 666600558878 660589 s58ell62 110051..54 116701.90 22425350s1 238165..98 335848..70 SSDD ((DDAAYY 4400)) 561 101.8 168.5 233.8 300.1 360.4 SD (DAY 40) 666600559910 5665.85 11917..06 115844..08 221583..52 237231.84 339353.14 SSDD ((DDAAYY 4400)) --~ | 35 `Company Sanitized. Does not contain TSCA CBI F:25231: OGneeneration Reproduction Study in Rats DuPont9763 ~~ _-- INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS Grove: TrI-1 DOSE: 75 MG/KG/DAY. oDvayTsEST: 1 8 15 2 29 36 ANIMAL NO. 666600559923 660594 5664..28 82.3 111061..16 108.4 117623..65 165.5 223316..56 227.2 239060..35 284.4 336617..00 SSDD ((DDAAYY 4400)) 345.0 SD (DAY 40) 666600559956 660597 387..03 30.8 11o6s..96 89.5 118429..78 146.2 224190..35 205.9 320890..12 255.3 337416..86 SSDD ((DDAAYY 4400)) 319.9 SD (DAY 40) 666600559989 660600 332..14 63.3 11946..65 102.4 1178.08s 158.1 221684..26 2182 237170..96 284.2 336276..43 SSDD ((DDAAYY 4400)) 360.1 SD (DAY 40) 566600660021 660603 S3570024 36.2 10879.s8 92.5 111474625...867 220374..28 2011 226974..07 257.6 333466..77 SSDD ((DDAAYY 4400)) 310.9 SD (DAY 40) 666600660045 660606 3366..66 23.8 9986..06 106.7 115585..21 168.2 221235..94 231.0 229528..27 298.2 336210..24 SSDD ((DDAAYY 4400)) 358.5 SD (DAY 40) 666600660087 660609 6626..57 70.0 110179..30 120.7 118587..40 186.3 222572..47 255.7 321875..63 324.0 335727..12 SSDD ((DDAAYY 4400)) 3835 SD (DAY 40) 660610 60.6 103.8 165.5 232.9 293.2 364.2 SD (DAY 40) --~ | --~ --------36---- lr e -- e -- -- Company Sautized. Does not caitain TSCA CBI F-25231: One-Generation ReproductionStudy inRats DuPont9763 --~ _-- INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS Grove: v-1 DOSE: 500 MG/KG/DAY oanvTsEST: 1 8 15 22 29 36 ANTMAL NO. 666600661112 660613 5S36.77 35.6 s8a..5 97.9 115553..91 153.6 222125..44 208.5 228744.18 261.6 334370..26 SSDD ((DDAAYY 4400)) 325.9 SD (DAY 40) 666600661145 660616 46'.s4 52.1 8967..50 893 114674..06 140.3 220385..14 198l5 226993..23 246.3 332560..72 SSDD ((DDAAYY 4400)) 298.4 SD (DAY 40) 666600661178 660619 S924065 26's 11915..37 103.2 117s0a.04 159.2 222218..44 213.5 2288491.14 276.3 334501.68 SSDD ((DDAAYY 4400)) 325.5 SD (DAY 40) 666600662201 660622 GS2500 277 1101s73a...216 117579..78 17.3 223268..20 240.2 229978.189 303)5 334674..09 SSDD ((DDAAYY 4400)) 359.3 SD (DAY 40) 666600662234 660625 S685l.64 62.3 110004..33 111.5 116509.042 172.8 221293024 241.6 228734163 3013 334355..31 SSDD ((DDAAYY 4400)) 372.3 SD (DAY 40) 666600662267 660628 5371025 7104 s7e0lss 113'6 15979..05 175.5 212398..09 240.4 219976..67 315.3 326553..73 SSDD ((DDAAYY 4400)) 377.8 SD (DAY 40) 660629 3705 9.3 161.8 230.3 287.2 345.4 SD (PAY 40) --~ | --~ | eer mma---- beens 37 Company Sanitized. Does not contain TSCA CBI H:25731: One-GenerationReproductionStudyinRats DuPon9763 ~. JE INDIVIDUAL BODY WEIGHTS (grams) OF Fy MALE RATS Group: VII-L DOSE: 3500 MG/KG/DAY oanvTsEs: 1 8 15 22 29 36 ANIMAL NO. 666600663301 660632 4485..04 37.6 8799..33 68.7 114451..50 107.9 220066..28 160.5 226637..46 217.5 333319..71 SSDD ((DDAAYY 4400)) 274.6 SD (DAY 40) 666600663334 660635 5219.030 4308 e8s4o9 835 114418.73 13.1 221053..82 199.0 227634..50 264.6 333303.52 SSDD ((DDAAYY 4400)) 329.4 SD (DAY 40) 666600663367 660638 6318.37 4203 10556..05 78.3 117021..45 13ls 125442..72 180.2 231102..65 230.7 236898..02 SSDD ((DDAAYY 4400)) 280.4 SD (DAY 40) 666600664309 660641 4414075 38.1 d77o.s4 ese 13809..74 124.3 114887..34 190.5 220458.176 249.5 321620..16 SSDD ((DDAAYY 4400)) 310.0 SD (DAY 40) 666600664423 660644 2502.5 376 7923..44 78.0 115197.13 127.6 126255..01 188.8 2281711.73 240.6 235439..13 SSDD ((DDAAYY 4400)) 300.1 SD (DAY 40) --~ |~ | SL sn -- 3 `Company Sanitized. Dos not contain TSCA CBI H.25231: OneGenerationReproduStcudtyiinRoants DuPont9763 --~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy FEMALE RATS Grove: TI-1 DOSE: 0 MG/KG/DAY ee oDxAYmSest: 1 8 15 22 29 36 ANIMAL NO. 666600664456 527.00 9914.s6 11239..77 116822..54 118918..92 220290..56 SSDD ((DDAAYY 4400)) SD (DAY 40) 666600664478 660649 3350:53 2002 7J3e7e 97.3 112236l3e 1asi0 116s0lllss suis 119835..31 212.1 220297..69 235.2 SSDD ((DDAAYY 4400)) 176.0 187.1 200.4 SD (DAY 40) 666600665501 660652 2509.31 235035 9975.94 99973 a14l6.s7 i13a5l9 117e6.01 169.2 129188..66 194.7 222379..68 SSDD ((DDAAYY 4400)) 218.4 SD (DAY 40) 666600665534 666600665565 2225:%2 33 8S9o.l5s S87 113323..37 147 116503..49 1es.8 118768..43 197.3 220048..81 SSDD ((DDAAYY 4400)) 213.8 SD (DAY 40) SD (DAY 40) 666600665578 660659 220:50 22.3 10s8e.l0s 513 11674..23 11a7al.z 211601.55 127086l06 213975..24 220393.199 222730..92 248.7 SSDD ((DDAAYY 4400)) 276.9 SD (DAY 40) 666600666601 660662 225%3 6 10B5e.z5 83 s1e0s7 118577..35 21718.18 223173..10 SSDD ((DDAAYY 4400)) ~ --_ ee 2 Company Sanitized. Does not contaiinnTTSSCACBI F-25231: OneGeneration ReproductionStudy in Rats DuPon-9763 ~ INDIVIDUAL BODY WEIGHTS (grams) OF Fy FEMALE RATS J Grove: TV-1 Dl OSE: 75 MG/KG/DAY. oanvTsEST: 1 8 15 22 2 36 ANIMAL NO. 666600666634 660665 5352.097 35.7 9845..37 95.3 114145..97 136.9 117572..58 175.2 119677..67 20411 218253..13 SSDD ((DDAAYY 4400)) 228.9 SD (DAY 40) 666600666676 660668 6S52.77 46.5 1007..73 804 115244.86 126.5 1195221.12 156.8 120711..33 179.4 128493..72 SSDD ((DDAAYY 4400)) 200.7 SD (DAY 40) 666600666790 660671 4535088 53.6 8e91.76 90.1 113229..36 132.0 116665..67 160.2 119829.102 170.5 221166..31 SSDD ((DDAAYY 4400)) 198.6 SD (DAY 40) 666600667723 660674 3260..41 281 e9e6l.1s 114378.23 117798..09 220155..70 225269..08 SSDD ((DDAAYY 4400)) eas 123.1 163.0 190.2 210.5 SD (DAY 40) 666600667756 660677 3360..47 86.1 985s..24 114.5 114335..23 150.0 117789..88 186.0 220050..42 224.4 222279..85 SSDD ((DDAAYY 4400)) 241.9 SD (DAY 40) 666600667789 660680 6S36.25 347 11s0e.l1s ssi 116363..42 126.5 1196611.54 16313 210729..74 179.6 222043..37 SSDD ((DDAAYY 4400)) 197.3 SD (DAY 40) -- || 30 `Company Sanitized. Does not contain TSCA CBI | 125231: OnGeeneration Reproduction StudyinRats Dupont9763 -- INDIVIDUAL BODY WEIGHTS (grams) OF Fy FEMALE RATS GROvR: VI-1 DOSE: 500 MG/KG/DAY oovamresst: 1 . 15 2 2 36 Ava wo. GGoooesse Gooey 515..88 60.5 9B70.57 927 114243.32 1423 118s21.87 187.3 21823415 20410 221601..35 SSDb ((DDAAYY 4400)) 236.0 SD (DAY 40) GGoeo0esssa S500029 7953.19 11216.17 11771733 11%%.8 222267..74 SSDD ((DoAAYY 4400)) SSG0oeeoessree 454293 19@0174930 1113357111ss 111768510.783 112%1s.127 222032220..1441 SSSDDD (((DoAAAYYY 444000))) SSSe00e69s01 565750.172 10s867o..s43 1M12e61l1so7 I1178s52..e40 22i01m83a1.l63 22193490491.143 SSSbD (((DbAAAYYY 444000))) SSee00e6sszs s3a2z3 Ss2e1y M123377 117592037 2111030173 2230101031 SSbO ((bDAAYY 4400)) 6600669545 360..94 9994.84 115303.27 118771.24 1290551.13 2222571.44 SSDO ((DDAAYY 4400)) 6660006669578 55300.01947 769776..1299 111240280.1710 11163s20a..464 112288413a9 222115607...105 SSSDOb (((DBDAAAYYY 444000))) 60695 S51 976 1437 1697 2011 226.5 Sb (DAY 40) ~ --~ - | || = -- `Company Sanitzed. Does not containTSCA CBI H25231:OveGeneration Reproduction StdyinRats _ DuPome9763 -- INDIVIDUAL BODY WEIGHTS (grams) OF F, FEMALE RATS Group: VIII-1 DOSE: 3500 MG/KG/DAY oonaress: 1 8 15 2 2 36 ANTAL vO. G6e6o0770010 60702 4477.50 33.0 a83l.s4 46.3 11250.8 80.6 I16l.o6 122.3 119972..07 158.8 222212..76 SSDD ((DDAAYY 4400)) 183.0 SD (DAY 40) 6S0077008 660705 4439.54 FD s(DeAeY 7) im.3 45.4 | 78.4 115.8 180.0 145.5 201.9 162.1 2422 sD (DAY 40) 196.0 SD (DAY 40) 66600770067 0708 5325..47 42.7 $622..35 78.2 112031..13 120.7 11339..56 149.6 118616..34 173.5 210897..26 SSDD ((DDAAYY 4400)) 20812 SD (DAY 40) S6e0r7i0o5 3453.14 7$34.s3 1112845s 11ae9ll.s2 118925..74 222020.033 sSDD ((DDAAYY 4400)) SS667721 S675 434s.8 e6s2.3 110m40 1l1a90o7 210760.10 219472.77 SSDD ((DDAAYY 4400)) ds sas 12901 167.6 199.8 22007 SD (DAY 40) Seria 440 73.4 1s Issa 174.7 202.3 SD (DAY 40) --~ | || ~ | | e-- ee ------------------ ESee-- eee-- neer-- eees-- eeee-- eteee-- eeee-- eeeem-- eeeme-- eee CompanySamlizad.Does not contain TSCA CBI H.25231; OneGeneration Reproduction Study in Rats DuPont9763 APPENDIX Z INDIVIDUAL BODY WEIGHT GAINS OF F; MALE AND FEMALE RATS --~ Pa J 3 `Company Sanitized. Does not contain TSCA CBI F-25231: OneGeneration Reproduction Study in Rats DuPont9763 -- INDIVIDUAL BODY WEIGHT GAINS OF Fy MALE AND FEMALE RATS EXPLANATORY NOTES Abbreviation - = Nodaa | | |- - 3 `Company Sanitized. Does not contain TSCA CBI 25231: OneGeneration Reproduction Study in Rats DuPont9763 --_ -_ INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy MALE RATS GROUP: 1-1 DOSE: 0 MG/KG/DAY onaTvEsST: 1-8 81s 15-22 22-29 29-36 1-36 ANIMAL NO. 666600557754 666600557776 666600557798 666600558810 666600558832 666600558854 666600558876 666600558898 666600559910 4366.055 12.8 s6.e7i 61s 7513.90 65.4 6590.12 65.8 5695..37 236096..31 67.1 3030 4425..46 3105 Gsoss. 62.4 6ss5..26 63.3 6579..13 52.4 764382 327180.54 600 2700 3753 esezs ms2e 75017 776.80 320762 358225 4615..85 5$8275 5760.52 6621.93 235170..01 s33l0s3 essess 6s1i7s 6e7l.s0 6479..75 324017d5 4a7s0l37 eesraa 773562 7804003 7926..24 33628978 4a5l7s esee.s7 6653..31 666338 66071.38 3209461.31 aai'lss s7e3d8 eesa.ss seeslss 579378 2372780.39 --~ ES `CompanySanitized.Doesnotcontain TSCA CBI H25231: OneGeneration Reproduction Study in Rats DuPont9763 --~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF F MALE RATS GRovP: Irr-1 DOSE: 75 MG/KG/DAY. onDTAEYSST: 1-8 815 15-22 2229 29-36 1-36 ANIMAL NO. 666600559932 a5s1i.a3 656s.5 7583.18 6643.s8 6664..57 329160.82 666600559950 4486l1s1 567sl18 6661.76 5579.82 6620..76 320832..87 666600559976 3a8137 ss6i.z7 5690.77 469947 6646..46 226899.31 666600559998 4a9105 6e5l1l5a 6G4014 6s6e.l07 5468.l8d 327032039 566600650010 a39l0a1 s5e5l7s 662031 6s90l8 5725.109 228976..38 666600660032 3326034 553720 5s5o.l4a s569.158 569373 225749.073 666600660058 aallao e57l.s1 6se7l2s 6a7e.s3 6682.25 326034.68 666600660076 5a2l1s3 eeslds 6642.s0 66731.52 e60z3 321902..47 666600660098 5a0a0l7s 6a5s.l67 6730.027 6598139 5Ga9l5s 328193.035 ~ 660610 3267 614 603 71.0 3036 ~~ 46 ~ Company Sanitized. Does not cortain TSCA CBI 125251: OnGeeneratioRenprodston SyinRats DuPons 9763 -- INDIVIDUAL 303Y WEIGHT GAINS (grams) OF 7, MALE RATS Grove: v-1 Doss: 500 e/x/DAY ononarass: 1s eas asa aes 296 1 ---- sSSoeoo0eeiii3z saDsa5 eSsser Geseass Se8s a1 eSHelas aadmesss SSSoaeoooeeeiiisse 0S$53p2 Esenoee sssveaee sswrabs Ssssesas osaeeevsse SSpoooioe1dts a3Sii mssesan gssruaos aemoen gsainsa mgeerrneee SSSoeeoo0eeeaz0is GGBefe seGinies swGemssa qsmoisse acseesod ss3eo0isss SSSooo0o0eeezzsza 8IS535 GsEeias sGeeses os53an2 maemoso eenseor GpGoooodeszeo D9392%07 Gsdei1es hseeiods ssvraess essssso zo00s6asds Sosa BF S88 wn ws 82 2 --~ || [PS | --_-- CompanySanlizd. Doesntcontain TSCACBI H25231:OneGeneration Reproduction StuindRayts DuPont9763 --~ INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy MALE RATS GROUP: VII-1 DOSE: 3500 MG/KG/DAY onDaTEySsT: ANIMAL NO. 666666000666333201 666600663330 666600663356 666600663378 666600664309 666600664412 666600664438 1-8 sls 15-22 22-29 29-36 1-36 343.039 esl6?2 6605..78 5670..28 6781.53 2208331.77 3371.17 38927 s6l1s s51707 5s7o.l1o 223872.002 3375..79 5564.64 6601s9 6650.86 e6s48 2288316 $223032 aesss 5e3370s3ss s7e5l.a7 322368.75 3S6390 4a5s1l5s sslBlao s58o1s3 4s9a1s7 2ai3s8l1e 3305055 5563.33 655766 556930 6670.55 22771092 24820029 464675 a6r5i2s a6s2l.72 5457.l86 220125.16 30a 4s.6 612 sis 895 25205 --~ 3 - `Company Sanilized. Does not contain TSCA CBI 1525231 One eneraionRepco Synit Dns ~ UDIIDUAL BODY WEIGH GAINS (grass) OF 7, FEIALE TS croup: 13-1 Doss: 0 weKG/oRY arontees: te eas msm mes 26 16 sm, vo. psSreevnceirs Gene 3PnaiiooonBsie3i mRBayaoa1mnaa Rioomiooam an mBRseioa1anmssd as ans fpSeerroeedst tees $7Wye3o0oonBoo33@e $rooGs a5B3s32 ai imBiIBBBIDR BD HS nOmEyd ad ttSeeeneeenssns Gonese B $B3io 0oo8a @st Er ose mnniia mi RkBpsD BD BB BS3u88a)d RS an GSSeeoonneeeassss rie fW$se3 ERIE Bdmden ST 3aGdn NB8d3I uRWdsd mfass RR Starceeers a$s308oo3Bs oBnsi Bmfi 6m2s WEsa ~ [I | | w Company Santzod. Doss not contain TSCACBI 25231: One-Generation Reproduction Study inRats DuPont9763 ~ --_-- INDIVIDUAL BODY WEIGHT GAINS (grams) OF Fy PEMALE RATS Grove: TV-1 DOSE: 75 MG/KG/DAY. onDaTeysst: 1-8 815 15-22 22-20 29-36 1-36 ANIMAL YO. 666600666643 666600666656 666600666687 666600667609 666600667721 666600667734 666600667765 666600667787 666600668709 3391.68 3491.a2 1 32.6 l20s.1 1257.a7 116372.44 239206 360 a4667 341 33853 27.4 285.29 1901 a2l48s 11777352 184 13500 3335085 39 4a2s7 473 334033 361 2282..46 235 224133 115632..85 2609 170.3 3394057 35s sailas 496 3218.27 07 216073 36.1 228313 117423.060 418 206.7 33'0s8 3al7 4sse0z aslo 3359..69 els 2271.62 25.4 2270.047 117516..48 203 178.8 4a6l6a 53653s 33061.10 36824 211765 116105.88 33030.54 aa7e 3286.42 1186.30 121073 114472.65 --_ | | --_ | 350 | Company Sanitized. Does not contain TSCA CBI 125231: OneGeneration Reproduction StudyinRas Depon763 --_ INDIVIDUAL BODY WEIGHT GAINS (grams) OF F FEMALE RATS Rove: VI-1 DOSE: 500 MG/KG/DAY onDTaEvSsT: 16 sas 1522 22:29 20-36 1-36 Ano vo. s6se0o6e8a12 2a697 maless 334855 24513s 23.20 i20s5.s7 sG660056883 2325072 ssolzs s#a5s0 215651 2329090 117r6s1l5s sse6ove8ssss 3402026 aasvll2o 338628 220190 22895 117667s S6e6v0e6s8a7 33s7l4s awriss 2a9l0s3 3m0s9 2100s7 lIselds 566600669809 3342 wallde 2293024 13625 228685 1167a2 ses060669912 3360s6 asolas a3s6s0 33103 23620 115787s 556600889934 33s2 3380a 32m80 2230 320638 l1e4s7ss 8S6600689956 237020 aa23 a3l6s7 2177s l2s1 lleeso ssesv0669087 660699 3130053 swollas aal7a 3340s5 325310 IIssmas a5 461 260 314 258 Ime -- -- { 51 -- | | `Company Sanitized. Doss not contain TSCA CBI 125231: OneGenerationReproduction StudyinRats Dupont 9763 -- INDIVIDUAL BODY WEIGHT GAINS (grams) OF F, FEMALE RATS Grou: vIII-1 DOSE: 3500 MG/KG/DAY onDATeYsSt: Ana No. 666600770010 666600770032 666600770054 666500770067 666600770089 656600771110 666600771132 660714 18 8s 1522 2-28 20-3 1-36 3w6.o4 4420.'4s 3m.i8o 229.00 2294.79 1i1n5.a6 310313 = a3s3l = amz2l 23:765s 32:032 11:522070 2333.0s0 s37l.a4 32020 2161.96 2331.29 l15a0.s6 23956 4a20lss 3268155 221073 2374.35 1i5e61s5 334s 4a0z0 335607 333422 22628 1170m08 32606s sayls aaiol 22613 326s7 11692as 337400 waisss 3s6ess 139232 227963 I1sae: --~ --~ I | wm CompanySanitized. Doesnotcontain TSCA CB H25231:OneGeneration Reproduction Study in Rats --~ DuPont9763 APPENDIX AA INDIVIDUAL FOOD CONSUMPTION OF F; MALE AND FEMALE RATS || - , 35 `Company Sanitized. Doesnotcontain TSCA CBI H:25231: One-Generation Reproduction Study in Rats DuPont9763 --_ INDIVIDUAL FOOD CONSUMPTION OF F; MALE AND FEMALE RATS EXPLANATORY NOTES Abbreviation - = Nodaa | | 354 | `Company Sanitized. Does not contain TSCA CBI H-25231:OneGeneration Reproduction Study in Rats DuPont9763 -- INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fy MALE RATS Grove: I-1 DOSE: 0 MG/KG/DAY onDTAEYSST: ANIMAL NO. 666600557754 666600557776 666600557798 666600558810 666600558832 666600558845 666600538876 666600558898 666600559910 --~ 1-8 8-15 15-22 22-29 29-36 1-36 0120.36 1206.0 a26s.4 2280.33 2279..18 2230.24 11320s 22000086 225571 22850s0 320855 222383 11020029 1188.16 2243.55 22581074 23810 2231006 1130a2 210832 22730037 32280a4 238673 2250s9 112801s 21060.60 2205033 2272.58 23623 123356 19332 210813 2251s8 2273010 3281.85 2193.66 112106 2221026 209005 3303.l4s 3al7s 2258.47 11320040 21080s8 2250.53 2276.59 33001.s4 2223047 11220040 2128..14 2236.84 229506s 23930a1 22a1l8s |~ | 355 Company Sanitized. Does not contain TSCA CBI H25231: OneGenerationReproduction StudyinRats DuPoni9763 ~ INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fy MALE RATS GROUP: TII-1 DOSE: 75 MG/KG/DAY onaTvEsST: ANDMAL NO. 666600559932 666600559945 666600559976 666600559998 666600660010 666600660032 666600660054 666600660076 666600660098 660610 --~ 1-8 8-15 1522 2229 29-36 1-36 143.l9e 128273 225575 2282.2 3310.66 224:.15 1131s 21171s 2260l0s7 2285064 32090.94 220222 n13l 1w8za 22a3l3s 22570a0 230024 22118 1u20ls 2is1i7s 2274072 2296066 3218..24 2224.51 1l3ls0 aisllee 22640s3 22790062 2393..48 2230..81 1l9o0l8z 11s7l2d 221173 22040189 22860076 2210.79 1123337 119a01 225371 2288a7 32639 2231.34 1is2ias 2193l15 2285l7s 2308011s 3322026 2263.80 ilslaa 2i3s1l17 2s8llos 3206015 3302.57 2262..00 123 10 22 ls 316 22 --~ : 356 `Company Sanitized. Does not contain TSCA CBI H25231: OneGeneration ReproductionStudy inRats DuPont.9763 -- INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fy MALE RATS Grove: v-1 DOSE: 500 MG/KG/DAY. onaTvEsST: ANIMAL NO. 666600661112 666600661134 666600661156 666600661187 666600661290 666600662212 666600662243 666600662256 666600662278 ~~ 660629 1-8 815 15-22 22-29 29-36 1-36 11.280 11790.09 2274.84 2268182 3310.02 2232..80 1a903 117606 2a0l4s 226044 2298010 2221.64 uuls 21061s 2251ss 226673 228711 2220.32 11220040 2181s 2m5i8s 22771.37 3310s1 2223.28 l12as 2200015 236566 227.50 320813 2192084 1i8l1s 1290051 2255a8 2268.86 3283..67 2233..81 1132.11 119s0 22e3l11 2275040 2390018 2212.097 100s8 2180d5 2256000 2298044 3313.14 2228.78 l7s.7 124000 -26a.8 3a2.9 232..43 2-5a.7 1205 211 267 284 323 242 -- ee -- a Food consumption inadvertently not collected on test day 22 -- i --35-- 7 e Compat ny Sanitiz-- ed.Doesnotco--ntain TSCA CBI 125231: One Generation Reproduction Study inRats DuPont9763 --~ INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fy MALE RATS Rove: vII-1 DOSE: 3500 MG/KG/DAY onamvesst: ANDHAL No. 556600663310 656600663332 8p60e83n5 SS6o006s3376 6s5s0o6e335e sa6s0066401 6s60066a4z3 s608as 18 sas 1522 2229 2936 1-36 mSels 11810 220370 2265s6 a3i5s a2i3e wselo aarlsa s1slls0 2231.s4 228065 218s6 n10i05 mmlzs aalno 2el2s lesn 22; 0 2725 2m00l1 21a2 229s8 a 20 21s7 a555 110s3 120a6 22005 221s4 12070a0 0s1u e16z1 a2105 22021 m2841 22030 1s3l5 119es1 226012 3z0l8 3203 21963 oi sls m2 za 0s as ~ |~ | er--------------------------E--E------Co--mpa--ny--San--iiz--ed--. Do--ss--not--co--nstaitn ai--n T--SCATSCA CBI H:25231: OneGeneration Reproduction StudyinRats DuPont.9763 --~ INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fy FEMALE RATS GROUP: 11-1 DOSE: 0 MG/KG/DAY onaTvEsST: ANDHAL NO. 666600664455 666600664487 666600665409 666600665521 666600665543 666600665565 666600665587 666600666509 666600666621 --~ 1-8 81s 15-22 22-29 29-36 136 0100.a9 1156.14 119673 11980.33 21080.78 1167.21 10o0lsa i1s6iss 11980s8 2128067 22200050 11871.30 1u2l22 117653 1al8ss 1191s 210721 116759 i12l0s5 1177.54 2200040 2201066 2221.51 1188s6 110078 1155525 117760 1178003 119805 116529 lsoly 1167s3 119642 2108011 2190173 118622 11230l26 21050.s8 1257103 21272s 2190.68 126153 19s1 11861s 2203062 21238s 2201097 119871 0128.2 i1s8i7s 1207017 s20l0o5 22070.17 126050 --~ 39 | Company Sanitized. Does not contain TSCA CBI H25231: OneGenerationReproduStcudtyiinRoants DuPont9763 -- INDIVIDUAL FOOD CONSUMPTION (grams/day) OF F, FEMALE RATS Grove: TV-1 DOSE: 75 MG/KG/DAY. onDaTEySsT: ANIMAL NO. 666600666643 666600666656 666600666687 666600667609 666600667721 666600667743 666600667765 666600667787 666600668709 --~ 1-8 sls 15-22 22.29 29-36 1-36 11020.70 o18w.l7s 119s.8 l13e.s9 1407.29 211521 1123003 210e0l8e 2s3l7a 2is6i2s 22210s8 210890 0ll2s 1156.11 1176.86 1176.57s 1158.38 1156..00 1u00s1 1oa6siss 21080103 21801030 219712 117676 1u2l0?7 1iess 217l.71 2l2e0i7s 2is0l6e 1195079 110038 117s00 misllee 128877 12920.74 116a3. 12a1 112s 2200025 221073 1205059 117802s 14338 2190041 22120 220040 220087 128021 110s07 1is6i4s 2s0l6o 1188l4s 2108004 1176..06 | - a. | `Company Sanitized. Doesnotcontain TSCA CBI H-25231: OneGeneration Reproduction StudyinRats DuPont9763 -- INDIVIDUAL FOOD CONSUMPTION (grams/day) OF Fy FEMALE RATS GROVE: VI-1 DOSE: 500 MG/KG/DAY ANIMAL onaTvEsST: NO. 666600668821 666600668843 666600668856 666600668878 666600668590 666600669921 666600669943 666600669956 666600669987 660699 1-8 8-15 15-22 22-29 29-36 1-36 152.99 1174.82 1198.07 218..52 2139..17 1159..91 wsilei 1167ss 2203027 21s1l0s 221048 11875.38 1mllss 1177018 210s070 2s0l6s 22000.s0 117880 m1lz s1l8s7 1270s7 127396 1237.68 126000 11220s6 1167057 1188.46 2201045 1229026 1178.37 110l026 1166l6s 11991s3 22000051 212938 1177.67 l10s08 1is6i6s 21070s 21710ss 2192020 116825 129062 1 146 1188s7 118a9 1290019 116.74 08038 1204053 21032s 2190.s8 2203006 1153..49 12 1803 201 182 217 18s --~ 361 CompanySaniized. Does not contain T5ccar H25231: OneGeneration ion Study inRats DuPont9763 --_ INDIVIDUAL FOOD CONSUMPTION (grams/day) OF F; FEMALE RATS GROUP: VITI-1 DOSE: 3500 MG/KG/DAY ANIMAL onDTAEYSST: XO. 666600770001 666600770023 666600770045 666600770076 666600770098 666600771101 666600771123 660714 1-8 8-15 15-22 22-29 29-36 1-36 11.201 1157.s8 119.22 210.4 2z1.l6 117.s6 w6-a2 1127030 - 1205008 - 12875 = 1B82l.e5 1124809 1s.i0e 1125055 1166.34 1177..58 118s.l80 115a.l8s 109051 1155.54 1178.64 1198021 221184 l1e6s6 11225 1165.04 21070.13 2191083 2230.11 11868a 18'5s 1138.09 2128043 12950.34 220516 126006 1l0.o4 11645 1188lse 2107061 2129.36 1176.38 -- --~ 36 `Company Sanitized. Does not contain TSCA CBI | 125231: OneGeneration Reproduction Study in Rats -- DuPont9763 APPENDIX BB INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTAL LANDMARKS, AND MORTALITY DATA IN F{ MALE AND FEMALE RATS --~ eee Gompany Saniized. Doss not ortain TSCA CB! H25231: One-Generation Reproduction Study in Rats DuPont9763 -- INDIVIDUAL CLINICAL OBSERVATIONS, DEVELOPMENTALLANDMARKS, AND MORTALITY DATAIN F; MALEAND FEMALE RATS EXPLANATORY NOTES Note Test Day 1= Postnatal Day 21 --~ |~ 64 -- | CompanySanitized.Doss not contain TSCA CBI B25231: One-Generuion Reproduction Study in Rats Dupont9763 -- INDIVIDUAL CLINICAL OBSERVATIONST,h D7.EVaELLOPMmEaNtTsAL LANDKARKS, AND MORTALITY DATA Grove: 1-1 DOSE: 0 MG/KG/DAY wna ner omssrvaTION OFBaSsEtRVEoDav O1BaS?ERVDEADY 660574 SPRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 660575 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCOEMSPTLDEATYE 40 660576 SPRAECPRUITFIIACLEDSBEYPADREATSIIOGNN TCOEMSPTLEDTAEY 40 660577 SRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCOEMSPTLEDTAEY 40 660578 SPARCERPIUFTIICAELDSEBYPARDAETSIIOGNN TCOEMSPTLEDTAEY 40 660579 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCoENSPTLEDTAEY 40 -- 660580 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCOEMSPTLEDTAEY 40 660561 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEOSMTPLEDTAEY 40 660562 SPRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN TCEoSwTrLDeATY 40 660583 SpRAECRRUITFIIACLEDSEBeYARDAETSIIOGNN TCEoSwTriDeATYs 40 660584 SBRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 660585 SPARCERGIUFTIICAELDSEBYPARDAESTIIGONN TCEOSMTPLDEATYE 40 I. 660586 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEQSUTPLEDTASY 40 2 = 2 2 2s 2s 3 z 2 2 23 = 2 2 2 2 2 2 23 2 3 2 2 3 || 660587 SPRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN TCEOSMTPLDEATYE 40 21 21 | --~ -- = Company Saniized. DonotscontsainTSCACBI F-25231: One.GenerationReproduction StudyinRats DuPont9763 ~ INDIVIDUAL CLINICAL OBSERVATIONSI,h DF,EVMEALLOEPMREANTTSAL LANDMARKS, AND MORTALITY DATA GROVE: 1-1 DOSE: 0 MG/KG/DAY ANIMAL NOMBER OBSERVATION FOBISRESRTVEDDAY LOABSSTERVDEADY 660588 PSRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN CTEOSMTPLDEATYE 40 660589 PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 660590 PSRAECPRUITFTIACLEDSEBPYARDAETSIIOGNN TCEOSMTPLDEATYE 40 660591 PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 22 22 2 2 23 2 2 2 --_ --~ | 36 - Company Sanitized. Does not coatain TSCA CBI H25231:One-GencrationReproduction StudyinRas DuPone9763. --_ INDIVIDUAL CLINICAL OBSERVATIONSI,h D7E,VMEALLOEPMREANTTSAL LANDARKS, AND MORTALITY DATA Rove: 11-1 DOSE: 75 MG/KG/DAY pry opseRvATION FOIBRSSETRVDEADY LOABSSTERDVAEYD 660552 PSRAECPRUITFIIACLEDSEBYPARDAESTIIGONN CTOEMSPTLEDTAEY 40 660593 PSRAECPRUITFIIACLEDSEBYPADRAETSIIOGNN CTOEMSPTLEDTAEY 40 660594 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 660595 PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN CTOEMSPTLEDTAEY 40 660596 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN CTOEMSPTLEDATYE 40 660597 SPARCERPIUFTIICAELDSBEYPADRAETSIIOGNN CTOEMSPTLEDTAEY 40 ~ 66059 PSARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 660599 SAPRCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDATYE 40 660500 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 660601 PSRAECPRUITFIIACLEDSEBYPARDAETSIIOGNN CTEOSMTPLDEATY 40 660602 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTEOSMTPLEDTAEY 40 660603 PSARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 . 660504 SAPRCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 4-0 660605 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN CTEOSMTPLEDTAEY 40 2 2 2 zn 2 2 2 2 2 2 2 2 2 pi zn zn 2 2 zn 2 25 2s 2 2 2 2 2 2 --~ Eg `Company Sanitized. Does not contain TSCA CBI 25755OCreomin RSr oy ee sa VEG CSE SRR,5 SeTrRe SRN 2 ARIE STA avn wes JE coors i sxaruniae szmmk rion coms Gios0r T sammiE e seE manScom. es SUS EA RINSSETATION SSNHEE somos E sammRe, sEemoanlcoams crt err e SR eatTS. E SsnTaEEmeLmo 0 ow nom nom FE--nom ~ | | ~~ --_------com-- pany Santa-- s,Bossot-- coTnSCaAGnBI H2S231:OneGeneration ReproductionStodyinRats ___ DuPoc9763 ~~ INDIVIDUAL CLINICAL OBSERVATIONSI,i DFE,VMEALLOEPMREANTTSAL LANDMARKS, AND MORTALITY DATA aRovP: V-1 DOSE: 500 MG/KG/DAY ANAL MBER OBSERVATION FOIBRSSETRVDEADY LOABSSTERDVAEYD 660611 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCOEMSPTLEDTAEY 40 660612 PSRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATY 40 2 2 2 2 660613 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 660614 PSRAECPRUITFIIACLEDSEBYPADREASTIIGONN CTOEMSPTLEDTAEY 40 660615 PSRAECPRUITFIIACLEDSEBYPADRAETSIIOGNN CTOEMSPTLEDTAEY 40 25 2s 2 2 2 2 660616 SPARCERPIUFTIICAELDSEBPYARDAETSIIOGNN TCOENSPTLEDTAEY 40 --~ 660617 PSRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN CTOEMSPTLEDTAEY 40 660616 SPARCERPIUFTIICAELDSEBPYARDAETSIIOGNN CTOEMSPTLEDTAEY 40 660619 SPARCERPIUFTIICAELDSEBPYARDAETSIIOGNN CTOEMSPTLEDTAEY 40 2 2 2 2 20 20 2 2 660620 APSLRAOECPPREUICTFIIIAACLERDSIEGBPHYATRDAEFTSRIIOOGNNNT C2AOWM(PSL)ET TEST DAY 40 20 2fi 660621 PSRAECPRUITFIIACLEDSEBPYARDAETSIIOGNN CTEOSMTPLDEATYE 40 2 = 660622 . ASPLAROCEPRPEIUCFTIIIACAELBDOSTEBHYPARDFARETOSINIOTGNNPCTAWEO(SMSTP)LDEATYE 40 . 2a2 2H 660623 SPARCERPIUFTIICAELDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 2 25 --_ | Company Saniized. Does not contain TSCA CBI BRB2E2522e31::Op OnneeGo esoertaditoonn Roeprodcuctiotn Stiuindo Rayts nSadyinRapDuubs Ponw.s9_n7e6s3 ~ INDIVIDUAL CLINICAL OBSERVATIONST,HBD,EVwEaLcOePMREaNtTsAL LANDVARKS, AND MORTALITY DATA r Grove: v-r1e ret--D--ose--: 50--0 uo/Ke ae/a terna A-- D omen osservaTION -- TCFoIR SRESRTvEDDAYS1oaemsseERwDvaEvD 660624 SpARCERRIUFTIICAELDsBmYeaDaESzIoGvN C78oSmTpreSTAsY 40 2 2 se0s2s SpArCeRsIvFrIICLEDssBYmaRDEaSTIIGONN c1o8v5e%LaDrAsY 40 2 2 660526 pSmAECzRvIrFIIaCLEDsBzYmmDaETSrIoGNN TcEoSuTerDEArYE 40 2 2% 660627 ESsTARaCEmRVvITEFIDIACLNEDpSREBBPYAORDDAEYTSIIOGvNNezTCoEowSnTpLDaRTYE 40 BS. 115 se0s26 SpArCReIFvICiEDsBEYeaDmEaSTIIGONN C15OSMTPLDEATYE 40 2 2s 660629 SpARCERRIvFTIICAELDsBmYeaDmEaSzIoGnN cTBoSmTerDeArYs 40 = 2 -- |~ | |b -_-- i|| 0 Company Sanitized. Does not contain TSCACBI F-25231: OneGeneration Reproduction Study in Rats DuPont9763 on INDIVIDUAL CLINICAL OBSERVATIONSI,NFD,EVLELEOPMREANTTSAL LANDMARKS, AND MORTALITY DATA GROUP: VIT-1 DOSE: 3500 MG/KG/DAY ANIMAL NOMBER OBSERVATION OFIBRSSETRVDEADY OLBASSETRVDEADY 660630 SPARCERPIUFTIICAELDSEBYPADREASTIIGONN TCOEMSPTLDEATYE 40 660631 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCOEMSPTLEDTAEY 40 660632 SPARCERPIUFTIICAELDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 660633 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 660634 SPRAECPRUITFTIACLEDSEBPYARDAETSIIOGNN TCEOSMTPLEDTAEY 40 660635 SPARCERPIUFTIICAELDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 -- 660636 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN CTEOSMTPLDEATYE 40 660637 SPARCERPIUFTITCAELDSEBYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 660638 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN CTOEMSPTLDEATYE 40 660639 WHEUANKCHED OVER SPARCERPIUFTITCAELDSBEYPARDAETSIIOGNN TCEOSMTPLDEATYE 40 660640 SPRAECPRUITFIIACLEDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 660641 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLEDTREY 40 660642 SPARCERPIUFTIICAELDSEBYPARDAESTIIGONN TCEOSMTPLDEATYE 40 660603 SPARCERPIUFTIICAELDSBEYPADREASTIIGONN TCEOSMTPLDEATYE 40 660640 SPARCERPIUFTITCAELDSBEYPADREASTIIGONN CTOEMSPTLEDTAEY 40 23 23 2 2 ES 31 22 22 26 26 22 22 25 25 2 23 25 25 55 66 30 30 28 28 . 28 2 25 25 25 25 23 23 || Ez `Company Sanitized. Does not contain TSCA CBI H2H525223311:OnGeeGneenreraattiionReproduction StuddyyinnRRaatss__ DDuubPonmts.r9e76s3. --_ INDIVIDUAL CLINICAL OBSERVATIONISN,F,DEFVEEMLAOLPEMERNATTASL LANDMARKS, AND MORTALITY DATA --_-- Grove: 11-1 DOSE: 0 MG/KG/DAY ANIMAL _-- NUMBER OBSERVATION =, 660645 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 OFIBRSSETRVDEADY OLBASSETRVDEADY TTT 10 10 660646 VSAAGCIRNIAFLICEPADTEBNYCDYESCIOGMNPLTEETSET DAY 40 1 1 660647 VSAAGCIRNIAFLICEBDATBEYNCYDECSOIMGPNLTEETSET DAY 40 1 n 660648 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 13 13 660645 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 1 1 660650 VSAAGCIRNIAFLICEBDATBEYNCDYECSOIMGPNLTEETSET DAY 40 12 12 --_~ 660651 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 10 10 660652 VAALGOIPNEACLIAPABTOTEHNCYFRCOONMTPLPEATW(ES) SACRIFICED BY DESIGN TEST DAY 40 11 115 660653 VSAACGRIINFAILCEPDATEBNYCDYESCIOGMNPLTEETSET DAY 40 13 13 660654 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 13 13 660655 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 1 u 660656 . 660657 VSAWGOILNLAELN LBAETFETNCFYRONCTOMPPLAWE(TSE) SSAWCORLILFEINCELDEFBTYFDREOSNITGNT0ET(ESS)T DAY - 40 VSAAGCRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 19 211 29 0 1n u |~ | --_-- | mn `Company Sanitized. Doesnotcontain TSCA CBI H25231: One.GenerationReprodiction Study inRats DuPont9763 = INDIVIDUAL CLINICAL OBSERVATIONISN,F,DEFVEEMLAOLPEMERNATTASL LANDMARKS, AND MORTALITY DATA _-- GROU: 11-1 DOSE: 0 MG/KG/DAY ANIMAL NOMBER OBSERVATION OFIBRSSETRVEDDAY LOBASSETRVDEADY 660658 660659 660660 660661 660662 VSAACGRIINFAILCEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFILCEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 12 12 10 10 13 13 3 13 12 12 --~ --_~ --37-- Company Sanitized. Does not contain TSCA CBI B2H-522532311:: OOnee-Generation Reproduction StdudyyiionRRaattss DuDPuPoonntt99763 INDIVIDUAL CLINICAL OBSERVATIONISV, 7D,EFVEEMLAOLPEMERNATTASL LANDMARKS, AND MORTALITY DATA re------Gr-- ove:--TV---1 ------ DOSE-- : 7-- 5 MG-- /KG/-- DAY.----e--r--e --. e ANIMAL _-- NOMBER OBSERVATION OFBISRESRTVEDDAY LOBASSETRVDEADY 660663 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 10 10 660664 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 1 1u 660665 VSAAGCIRNIAFLICEBDATBENYCYDESCIOGMNPLTEETSET DAY 40 13 13 660666 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIGMNPLTEETSET DAY 40 10 10 660667 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 10 10 660668 VSAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 8 15 -- 660669 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIGMNPLTEETSET DAY 40 660670 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 18 18 1 1 660671 VSAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLETTEEST DAY 40 u 1n 660672 VSAAGCIRNIAFLICEBDATBEYNCYDECSOIGMNPLTEETSET DAY 40 10 10 660673 VSAAGCIRNIAFLICEBDATBEYNCDYESCIOGMNPLTEETSET DAY 40 12 12 660674 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 22 22 660675 VSAACGRIINFAILCEPDATEBNYCYDECSOIGMNPLTEETSET DAY 40 - 12 12 660676 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 3 13 --~ --- EQ Company Sanilized. Does not contain TSCA CBI H25231 OneGenerationReproduction SuindRayts Dronres ~ INDIVIDUAL CLINICAL OBSERVATIONTSN, DEFVERLAOLPEME1NTAL LANDNARKS, AND MORTALITY DATA ---- Grove: 1v-- -1 Do-- se: 75 a/xEaA/-- oEnyes -- e sm mn, wovsen onr semunzzontimpe CFzhiSsErNEaDv BwOaBEsStERRVpEaRDy ESAy CRIFICED BY DE-- GEON THOT DRY 40 s s 6070 aSACcRImFICEpDaBrYmDEScYoOmNpeTtEeST DAY 40 12 2 660679 vSAaCcRnIuFuICEeDaTBmYNCyDEcSIoGmNpeTtEeST DAY 40 12 12 G0st0 SAvCaRgInFwICEpDarBeYNCDYEScIoGmNPLTEETSET DAY 40 12 " ~ Pa t----------------i----5Seeeeemmpoms Company Sanitized. Doss not contain TSCA car HZ-2B52L31:: OneGGeenneerraattiioonnRReepproductionSutuddyyiinnRRaats DDuupPoonmt9e7s63. ~ INDIVIDUAL CLINICAL OBSERVATIONISN,F,DEFVEEMLAOLPEMERNATTASL LANDMARKS, AND MORTALITY DATA -_-- Grove: vI-1 DOSE: 500 MG/KG/DAY a ANDMAL NUMBER OBSERVATION OFBISRESRTVEDDAY LOABSSETRDVAEYD 660681 660682 VSAACGRIINFAILCEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFLICPEADTEBNYCDYESCOIMGPNLTEETSET DAY 40 16 16 bt iY 660683 SVAAGCIRNIAFLICEPDATBEYNCYDECSOIMGPNLTETEEST DAY 40 15 15 660684 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 EY 1 660685 VSAACGRIINFAILCEPDATBEYNCDYESCOIMGPNLTEETSET DAY 40 n u 660686 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETEST DAY 40 u u --_ 660687 VAALGOIPNEACLIAPBAOTTEHNCFYRCOONMTPLPEAWT(ES) SACRIFICED BY DESIGN TEST DAY 40 660688 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 660685 VSAAGCIRNIAFLICEBDATBEYNCDYESCIOGMNPLTEETSET DAY 40 1a3 2103 u u 1 u 660650 VSAAGCIRNIAFLICEBDATBEYNCDYESCIOGMNPLTEETSET DAY 40 1 1 660691 660692 660693 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 VSAACGRIINFAILCEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 VSAACGRIINFAILCEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 15 15 1 1u 18 18 || 660694 SVAAGCIRNIAFLICEPDATEBNYCDYESCIOGMNPLTEETSET DAY 40 10 10 | ~~ | 376 ---- | Company Sanitized. Does not contain TSCA CBI H:25231: One.GenerationReproductionStudyinRats DuPont9763 ~~ INDIVIDUAL CLINICAL OBSERVATIONISV,F,DEFVEEMLAOLPEMERNATTASL LANDMARKS, AND MORTALITY DATA GROVE: VI-1 DOSE: 500 MG/KG/DAY ANTAL, NOMBER OBSERVATION FOBISRESRTVEDDAY LOABSSETRDVAEYD 660695 660696 660697 660698 660699 VSAAGCIRNIAFLICEPDATEBNYCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATEBNYCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 VSAAGCIRNIAFLICEPDATEBNYCDYESCIOGMNPLTEETSET DAY 40 2 12 15 15 1 17 5 5 3 13 --_ | |~ | | -_-- | 377 `Company Sanitized. Does not contain TSCA CBI H:25231: OneGeneration ReprodSutcudtyiinRoatns DuPont9763 ~~ INDIVIDUAL CLINICAL OBSERVATIONIS,F,DEFVEEMLAOLPEMERNATTASL LANDMARKS, AND MORTALITY DATA Grove: vIrI-1 DOSE: 3500 MG/KG/DAY ANIMAL NOMBER OBSERVATION OFIBRSSETRVEDDAY OLBASSETRVDEADY 660700 VSAAGCIRNIAFLICEBDATBENYCYDECSOIMGPNLTEETSET DAY 40 660701 SVAACGRIINFAILCEPADTEBNYCYDECSOIMGPNLTEETSET DAY 40 660702 SVAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 660703 VSAAGCIRNIAFLICEPDATBENYCYDECSOIMGPNLTEETSET DAY 40 660708 WHEOANKCHED OVER FOUND DEAD TEST DAY 7 660705 SVAACGRIINFAILCEPDATBEYNCYDECSOIMGPNLTEETSET DAY 40 --_ 660706 VSAAGCIRNIAFLICEBDATBEYNCDYESCIOGMNPLTEETSET DAY 40 660707 VSAAGCIRNIAFLICEPDATBEYNCYDECSOIGMNPLTEETSET DAY 40 660708 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 660709 SVAACGRIINFAILCEPDATEBNYCDYESCIOGMNPLTEETSET DAY 40 660710 SVAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLETTEEST DAY 40 660711 VSAAGCIRNIAFLICEPDATBEYNCDYESCIOGMNPLTEETSET DAY 40 660712 VSAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 660713 SVAAGCIRNIAFLICEPDATBEYNCDYECSOIMGPNLTEETSET DAY 40 660714 SVAACGRIINFAILCEPDATBEYNCYDECSOIGMNPLTEETSET DAY 40 13 13 12 12 21 2 10 10 65 66 3 13 12 12 1 1 13 13 2 12 3 13 15 15 13 13 12 12 20 20 578 Company Sanitized. Does not contain TSCA Cal H22552231: OOnnee.GeennerattiionRReepprroductionStuuddyyiinnRRaats ___ ~~ DDuuPpoontm.o97e63s APPENDIX CC INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA -- P; ADULTS --_ ~ 7 -- `Company Sanitized. Does not contain TSCA CBI 125231: One.GenerationReproductionStudy in Rats Dupont9763 --~ INDIVIDUAL ANIMAL CLINICAL PATHOLOGY DATA -- P; ADULTS EXPLANATORY NOTES Notes TTetDDasys7167950 == PCroebmiaaitnognppereiroidod wWhhicehnianrdeievixdpulaalinaendiimnatlhdeastuardyrneoctorredported,itmaybe de 0oneof th Following ressosce esos, llof thahhveeeas rlsiawdmapra elsseiuwlnatasm cussofccuolilp otedtntstoedtal s(balCmepeLole ObefTtofar)oitrnetsetedisn(ignRgN(YQ)NS) ih0esaanmipmlaelwdaisedpvriaorltiosaomrpleestcionlgl(eNiSoRn) Abbreviations: GeneArDalE:Q - sdequute DEORK RNV rsdaemi cprencoetdt ovalniddOiKtfoirtsoinng -- UTD untaodbetelrmiene IndiCvORidNEuDCalHe-martesodalmobpglyelcoVnacodleiulteliosco:nodun HHGCBT ~ hheemmomgolcorbtin MMCCHV MCHC mmmeeeaaannncccooorrrpppuaussscccualllaaarrhvheomelomguolmooebbiinnconcentration ARRDEWT PLT rpbelduacaieltdtcroieuelttoeiylowiodnuthnt AWNEEUC ALYM aabbhssiootlluutbtelnoloydemcpehluolccyrotu(enaolt fporhms) i : AMON ahiolutemonotyie . AABOASS issbcaohbuatscoopshnoiplhi ALUC abslargoeunlssnuedctll ~ || 380 CompanySaniized. 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