Document a1Xgopv6w3Gkgz24JBMMwdvEb
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Hew B05 MR Y 11933
AR226-1308-2 s-0%
Final Report
Study No.:
Study Title:
5-088
A Case-Control Stucly of Leukemia
at the Washington Works Site
Principal Investigator: rfEM.erEeidzaebsemth:Karns, MPH.
.
Co-Investigator: Di`SWoiimlrlraiVaemcEa.pFaeyenrveiatsher,SPehi.Dn, MPH.
Study Sponsor:
Polymer Products
Study Initiation Date: 05/01/89
Study Completion Date: 12/31/91
J
Page 1013
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FiPnoagleR2e0po1r3t -StudyNos:5-088
Table of Contents
BagelNo. I ReVEWANdAPPIOVA cress}
CPOLIIMCVIEDSaHlEIRNMVOERS(HSG)Rc OTco orvees n es anees eeeeeoessonns 3
Ie IEO30CHOR commonsense
ABSHACE css
PUIPOSE cosmos LD
eer
TIL RESEATthMEthOSconor ssnssmssnemssmssssmmmssmsmsonsS SY DESIGN cosmos LEEXPOSUIEASSESSTIOTErareees s t
TV. RESUS cosmos 6-1
Vo DISCUSSION corsets
12
VE CONCUSION ress 2
VIL ACKIOWIEGBEMENtScommsemsnnosnmssessmnmmsonrmronn 13
VIL REETERCES coosssmssssssssensmsesmasomsesssssssssssmesmm1n3
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15
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ets
RLO02163
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Fos Report.StyPaHgaesotis
REVIEW AND APPROVAL
the studTyatatnedstptrhoact,edtuortehse ubseesdt,ofr:ef`lmeyctksnothweleddagtea,, athnids rtehpatorttheiss.tsucideyntwiafisccalolnydsuocuntde,d dienscribes
cthoemprleisaenarccehwpirtohtotchoel,apapnrdoparniyataemernegdumleantotrsy
requirements, thereof.
Good
Epidemiology
Practices,
submines:_ M LGFo
Dae:SDeeceemmie S31y,64
SA 48LGe8ttl doT iSe dEeT: g te ece g Dae: LPeoais 20,171; )
2 Vou Approved: Ag Q= ty
ues :Latins i 311% |
a
SS
eorsioss
ic
Ru002164
eFinsalsRaeport -Study Nos 5.083
INTRODUCTION
ABSTRACT
Acase-control study Ceveloping leukemia
s(SrteuldayteNdo.toSw-o0r8k8p)lwaacse
IenxiptioastuedretsoadtettheremWiansehwihnegtthoenr
the risk of Works plant,
TpahretisctuluadryjfoobuonrdanroeaasgsroocuipaitniognabnedttwheeernisekmopflodeyvmeelnotpiantgWlaesuhkienmgiat.onAWostraktisstiincaallnyy
`scihgneimfiisctasnptrieoxrctesoswoofrklienugkeamtitahweaWsasohbisnegrtvoend Winortkhso.seTwhheosewofirnkdeindgassacreusbtaosdeiadnosnorfew
cases so that considerable variabilty was observed in the estimated odds ratios.
PURPOSE TrehleatpeudrtpoowsoerokfplthaecesteuxdpyoswuarsestoatdettheerWmaisnheiwnhgettohnerWothreksripsklaonft.developing leukemia is
RATIONALE TofhelesutkuedmyiawaatstshtearPtaerdkeinrsrbeusrpgo,nWseestto Veimrpgilnoiyaeseitec.onPcrieorrntsortehgearpdriensgenatnsatpudpya,reanctlucsltuesrter iinnivteisattiegdaatfitoenr haandebleeveantecdarsrtiaenddoaurtdibzyedWailnrcaitdhenacnedraBtuiork(eSI(R19=819)..47Twhietirhi6nvoebssteigravteidon was cadadsietsiovn,eresmupsl4o.y0e8eecxopneccstrednscawseerse)awlasasrdaeitseecdtreedgdaurrdiinngg rnoeuwticneasceasncoefrlesuurkveemiilal.ancNeo. In `wcaosmumnednearlttaykoefnetxopdoestuerremwinaeswfhoeutnhderwhtheenlweourkkemhiiasctlourisetserwweares rreevliaetweeddt.o Tthhieswsotrukcy environment .
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RLO02165
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Final Report - StudyPaNgo.e s5o.f08133
RESEARCH METHODS
STUDY DESIGN
ACacnacseer-cRoengtirsotlrys.tuTdhyedCesaingcnerwaResgiussterdy. isClaismeitsedwetorecaIndecnetrifcieadsetshrdoiuagghntohseedDuamPoonntg raecsttirviecetemdptlooytheoesseadftiearg1n9o5s5ed(Pweiltlhetleaul,ke1m9i7a8wahinldeOwBorekrigngetatalt,he19W8a7s).hiCnagtsoens Wwoerreks site during the period 1956 to 1888.
Four controls were selected corresponded to the case's
dfioargenaocshiscyaesaer.frEoamcthhecosnitter'oslewmapslomyaetechroesdteornthgaetnder,
year
of birth (within three years), and payroll status at the timeofdiagnosis.
[EXPOSUREASSESSMENT
ODucrcautpiaotnioonfaelmepxploosuyrmesewwnaestrecadlectuelramtiedneidn etahrcohujgohbjtoitbletialnedanardewaocrokmbairneaatimoant.rices. Awletrheoauvgahilaanblaetftoermtphtewmaasjomriatdyeoftosuubtjiecztest.he chernical-specific information, tle data
DATAANALYSIS
Cboentdwieteionnaelxploogsiusrtiecarnegdrtehsesiroinskmoofddeelvselwoepriengusleeudkteomiaass(eRsosthpmoassni,bl1e98r6e)l.atTiohneshEigprset `soodfdtswarraetipo awcaksagcaelcwualsatuesdeads taondeirnicveex tohfetehsetsitmraetnegsthofofretlhateivreelraitsikon(sShEipR.C,Ni1n9e9t0y).peTrhceent c`oedndfsidreatnicoewihnotesrevallsowweerr8e0c%alccuotnaftieddenfocreeraatciho oedxdceserdaetido 1a.s0awnasinddeefxionfedvaarisabsitlaittiys,ticAanllyy significant.
a
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RLoo2166
*FPinaaglesRoerpoirst-Sty Noa 088
RESULTS
nTohne-nyimnpehcoacsyetsicwelreuekdeimsitarsi,buttherdeeovweerrasrcahnrgoneiocfmlyeeulkoecmyitaictylpeeusk.emiFaivse, caansdeasnweerweasacaunte
acute `come
lymphocytic leukemia. These are from a common exposure (Linet,
distinct 1985).
leukemia
types
which
arenot
thought
to
cAonctormoplasriissionnTaobfldee1m.ogAlrlaspuhbijceactnsdwweorrekmaelxep.erTiehnecmeacthcahraicntgeroifstciocnstrboeltswteoecnasceassewsaasnd `rseugcacredssifnugl:agneo osrigpnaifyicclaanstsd.ifTfaebrleenc2escwoemrpearoebssetrhveewdobrektewxepeenriceansceesbaentdweceonntrcoalsses and controls.
Washington WoTrakbsleL1eukemia Study: Characteristics of Cases and Controls
l Vaal
II Name
||
Sinn year 190233
119993744326
1943.54
cases
* onf=ca9ses
coos |
% ofnc=o3n6trols
2
I
225
=
PaSyalcalrayss: Wage
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Etstoes RL002167
[Vari=able fons
Final Report - StudyPaNgoe.75f.08183
Washington WoTrakbsleL2eukemia Study: Employment Characteristics of Cases and Controls.
Cans=e9s mean (80)
Co`nnter3o6ls mean (50)
209 | ee |{
|
ew | een | we |
[mre | wea | ow |
O(Tcacbulpea3t)i.onCsusptroiodriatonscoamnidnegntgoinWeaesrhsinhgatdosntaWtiosrtikcsallwyesriegncifaitceagnotlryizeeldeviantteodniondedgsrroautiposs c(oOnRs)torfuc8ti.o0n(,9o0ff%icCel,:a1n.d1,o6t0h)eranwdor7k.e9r(s8h0a%dCeIl:1e.v0a,te76d),burtesnpoetctsitavteilsyt.icaClhlyemsiisgntisf,icant odds. ratios. 4I)n.duTshtroyseexwpheroiewnocrekperidoirnttoheWasserhviincgetoornrWetoairlkssecwtaosrscahtaedgoarnizeleedviantteodnoindedsgrroatuiposof(T4a.b1le (90% CL0.9, 17.5); however, this was not statistically significant.
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E1106 RL002168
Pogesorss
"Final Report - StudyNo.: S088
OccPupraotion
MatcheWdaOshdidnsgtaolnoWoaTrnakdtsi5eL0ae%ukCeomnfiiadSeunscye:interval on Prior Occupation Group. Nolucmonbtreorls Matotcunosag |ontshReuacocaus
i Go | Chemisy
2
27
os 154 |1
1
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[ome| | [oor|
EREENENE
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1 Other
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07
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[meme][ee]
-- a2
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FiPage 1R0e0pfor1t3Sy Nos 5.088
oWfasdhatiangptroenclWuodrekdfseurxtpheerriceonmcbeinwaatsioannsaloyrzsetdrbatyifjiocabtitointsl.e
andbywork area,
Job titles were ca
t
The
egor
paucity
ized
ienntgoineiegehrtsg(rOoRu=p5s.1()T,abolfefi5c)e.woErlkeveartsed(OoRd=d2s.0r)a,tiaosndwecruestoodbisaelrwvoerdkienrcshe(OmRi=s4t.s0)(.OR=A1l.9),
confidence intervals on the odds ratios included 1.0 and were not `statistically significant.
Work done
areas were grouped by determining if the
into nine categories (Table `subject had ever worked in
6).
Thework
areaanalysis was
a1.r5e.a.HoMwaeivnetren,aanlcl ec,onlfaibodreantcoeriienst,eravnalds oifnfcicleudaerdea1s.0h. ad etlheevaarteead oordndesvreartiwoosrgkreedatienrtthhean
MatcheWdasGhaicnegtRooarnioWooanTnnaTkbtsol5eeL05sr%ookCeonmnidaeSntcusy:nterval
| !
EA
dNooo--r | RwSaaovsee'd || nspopowtcsne |
[[=Fo~re| n T T T o T [a]
[oe |Te a]
(=TTi e] 1 we|ee 04 ee I
[I =~ [oe
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]
_. wos
te an SOR
3
Rzooz1n
Reproettsens MnaSWn eL sumSeeE ag aestsuer
gnomw || dmuemwm|| vvweemssos ||| socommeeer |
[om i 2 Nylon/
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1
|=|
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LL a
om raoosiz
:
FPiangael1R2e0p1or1t3-Study No: S088
This study of employment
leukerriaatthe in any particular
WjaobshoirnagrteoangWroorupkisnfgoaunndd
no th
arsissokcoifatdieovnelboeptiwnegelneukernia,
2Asstactuissttoicdailalnyssiogrnicfhiecranitstesxpcreisosrtoof lweourkkeimnigaawtatsheobWsaesrhviendgtionnthWoosreksw.hoThfoersmeerfliyndwiongrsked
are based on few cases, thus wide confidence intervals bracket the odds ratios.
MTihsicslsastsuidfyiccaotuiolndobfeexmipsossiunrge2astraueppproosixtiimvaetaesdsobcyiawtoironk bhiesctaouryseisopfosasnibulmebaenrdofcofauctdors. tlielaedatnodawfiatlhsoeuntekgnatoiwvleedregsuelto.f tHhoewseuvbejrec,t'ssinccieseexapsoessutraetuwsa, sthiassissiugnnliekdeblya.sedon job aMiwsacrleasnseisfiscaotfitohneodfitsheeadsiesaetastehestsiatte.us Ailssaol,ssoepvoesrsalibtlyepteshoofulgehukuenmiiikaelayregigvreonutpheedhigh ltaotgeentchyerpeirnitohdiss,staunddy.difTfheeresnet taygpeesgroofulpesukaetmriisak.probUanbmleyahsauvreedcicfofnerfeonutnedteiorlsogsiuesc,h as cigarette smoking and non-occupational exposures could also play a role. The smal ansusmocbieartioofn,cases severely limits the statistical power of the study to detect a true.
aTnhde pcohseimtiisvetsfipnrdiionrgtoofjaoinnienxgcDesusPoofntleiuskpermoivaoakimnogn.gBtohtohsoecwchupoatwioornksehdaavsecpuosttenotdiiaalns o`fexlpaocskuorfesspteocimfuilclipnlfeorcmhaetmiiocnaolnagtehnetesxaponsduerxepsoisnutrheeisr cfoourlmderbjeoabts,hiagnhdllevaeclks.ofBecause cuonndcelrusstiaonndsincganofbtehedrsaewlne.ction process that brought them to Washington Works, no
pTahritsiccualsaer-cWoansthrionlgsttoundyWoofrklseujkoebmoiraafroeuandgrnooupasisnogciaantdiotnheberitswkeoefndeemveplloopyimnegnlteuikneamniya. pTehresissittse asnhdouadnybpeamttoenrintsereemderfogrefuwtiutrherceasspeesctotfolweourkkpelmaitcoae edxeptoesrumriensei.fthe excess
rt ree
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RL002173
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Final Report- StudPyagNeo:135.001838
ACKNOWLEDGEMENTS TOchceupaautthioornsalwoHeualldthlikceontsoutlhtaanntkst,hAemWyasBheirnggtaonndWBiolrl AknssdtearfsfownhoancdoltlheectEepdidtehmeidoaltoag,ythe Spercotcieosnsipnrgogarnadmamnearlsy,siAslfaonr Mthaisnnstuadnyd. John Gerlach, who assisted in the data
LPirneests,,M1.9S.85The Leukemias: Epidemiolocic Aspects, New York: Oxford University
OBerg, M., Burke, C., Chen, J., Walrath, J. Pel, S., and Gale, C., "Cancer incidence a19n8d7,mo2r9t:a3l,itpy.i2n4t5h-e25D2u. Pont Company: an update iJn ournalof OccupationalMedicine,
Pel, S,, O'Berg, M., and Karrh, B., "Cancer epidemiologic surveillance in the Du Pont
Company" in Journalof Occupational Medicine, 1978, 20:11, 725-740.
Rothman, 298.
Kenneth,
Modern
Epidemicloay,
Litle,
Brown,
and
Company,
1986, p. 297-
Statistics and 1, Revision 1,
Epidemiology 1860.
Research
Corporation,
EGRET
ReferenceManual,
Version
WWaalsrhaitnh,gtJo.nanWodrBkusr"k,e,intCe.rn*alAnReipnvoersttifgraotmiotnhientEoptihdeemoicocluorgryenSceectoifonl,euMkeedmiicaalatDivision of the Du Pont Co., revised Apri, 1989.
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