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[[ amonrotors| Update to Submission ofMay 18"
1) tLeetrtaetrolforgoymstEu.diMeasr,sdhaatleldJDoehcnesomnbetro W7,il1l9i8a3m. C. McCormick, II, re Hazleton 2) sLteutdtieersfornomPEF.OMSarasnhdalelthJylohFnOsSoEn,todaWtieldliNaomveC.mbMecrCo1r2,mi1c9k8,2.IIT re Riker teratology
8. N-EtFOSE alcohol|N-ethyl perfluorooctane sulfonamidoethanol
1) sLteutdtieersfornomPEF.OMSarasnhdalelthJylohFnOsSoEn,todaWtieldliNaomveC.mbMecrCo1r2m,i1c9k82,. Ill re Riker teratology 2) EFitnhaalnoRlep(oNrett,-FBoisoel;ogTi-ca6l31P6h)asIen,CMyentoamboollgiusmsoMfoNn-kEetyhsylFoPlelrofwliunogroAodcmtiannisSturlaftainoonmoidfao
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04135
JE-FFERSON ME.DICAL COLLEGE
T
THOMAS JEFFEoRfSON UNIVERSITY
!
DDaenpiaelriniBeaenughooffIrteasmes Director ond oniman
uk |
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December 7, 1983
Phiadoettsp)hii,s3a1c0n7
TMro.xicWoillolgiyanSeC.rviMceeCso,rmiMcekd,ica1l11 Department S2t2.0-2P5aul, MNCentSe1r01
Dear Mr. NeCommick:
TIevhaiveew rfeicnedivietdtothebodraafctleraerployrtexpolfaiT3n3e5d1stfurdoym.Dr.ItWeitszealsatnadte-aofft.erthec-aarretful Safety evaluation for developmental toxicity.
TG"hrteoourpdattwaarseadtethmmeeonnmtsotrraeattbesoetvsheevreerleyanmdaaftf1ee0rctnaeagdl.T3t3o5xTi1ic/eiikrtgy/dfaoisodaenvdiindttehaanktte
btohtehhidguhreirngdoasnded was reduced and,
flootsseosnlbyecduirdretdheindambsotnhott.hepsaeintwreeiagthntenntorgmraolulpys,. aNcutmuealroumsatcelmianlicawleigshitgns of
mTaetleartneadlreddiusctrteisosnsanidn ofevteanlhabiordylowsesigwhetrseforbosnertvheeds.e 11T1herdeansw.ereHodwierveecrt,ly
dFoerlayssuchtha1n11omnoethmeirgshtanedxpescntallinfestuucshess,evetrheelSy nsgtregrsosuepd msohtohweerds.fowNeor sskieglnestaolf
eeIxnietrshthesorrton,naltayotmaadlorseeloratlideveveveleslfoepwsmeevoneftraetllhyetamodaxvtieecrirstneyalelofcyfceutcrotrxseidconainndthteehevecnolnocwleeptdthouaslse, ognrTeo3u3p5.1
oCTuoasutledotohfeexspfeectstai.lgnsdeAtvoeflaomapdotmseeernntalleavnedtl,oxaibtceiltotywh,e tahtlahlterepirmwopedoruretcainontgnlmmyaattmeeirrnnnoaarlllefydefaentcohtn,stoxobinuct tdnheousmeer-
Tevel, enbryonic and fetal development were absolutely normal.
acThnoidnsceopnstetuuswd.oyulcdlTheeacromlnoycltuhidelerlusattphrpaaettaaersss lmotohnrege assvaufleentxeyproaosubfrleetshetoarteeTs3t3k5e1pstubtshbatenalnowcteheadfuoclrotnctehtpeotxuisc
Tevels, enbryonic development would also not be affected.
SThaifsetys.tudyYouofhaTv33e51gomnaeketsheaexctlreaarmislteateamnedntareoftoa bneo cefofnegcrtatulleavetledanfdorfoytoaulr
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04136
Page 2 WDielcleimabnerC.7, Mc1C9o83rmick
hbiegihngmoctoinvfautsieodn.by,
Iorcahnnaovtingenvriessieornvataiocnusstormeegarrdoirnga,
rethgiusladtaotray
agency base
clearly establishing T3351 to not represent a developmental hazard to the
conceptus.
Sincerely,
E. Marshall Jojffeon, Ph.D. Professor and Chairman Director, Daniel Baugh Institute
EMI ranf cc Dr.
Lawrence
T.
Wetzel,
Ph.D.
Department of Toxicology Hazleton Laboratories America,
Inc.
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04137