Document ZpkMXdmm6BvB9abmy2jJ0pb8

FILE NAME: Oil Industry and American Petroleum Institute (API) DATE: 1947 Nov 13 DOC#: API006 DOCUMENT DESCRIPTION: Meeting Minutes & Attendee List - API Medical Advisory Committee Fot Infornatiod Only - Not Por Publicatlon AMERICAN PETROLEOM INSTITOTE MEDICAI ADVISQRY COMMITTEE SIXTH MEETING J Minutes of Meeting November 13, 19^7 Stevens Hotel Chicago, Illinois jffMBEPg. PRESENT II s-\ V. C. Baird F. F. Boys W. W. Brooks Kieffer Davis ASSOCIATES PRESENT E. W. Adams L. C. Beard, Jr. R. S. Bonsib R. C. Cole SOESTS R. C. Allen I I ADVISOR D. V. Stroop - API Mclver Woody - Presiding J. P. Holt - Secretary A. E. Hoag B. A. Jewett T. J. Kelly w . B. Levis A. E. Dooley H. W. Field H. G. M. Fischer N. J. Gothard B. B. Boaper Marshall Clinton, Jr. Philip Drinker Total in Attendance - 31 E. K. Linder B. C. Page B. B. Beeve H. B. Warrick F. M. Watkins H. D. Wilde H. H. Zuidema F. F. Heyroth MEMBERS ABSENT W. 0. Armstrong D. M. English T. M. Frank W. A. Morrison M. N. Nevquist H. S. Thomson '* } ASSOCIATES ABSENT C. R. Brown R. S. Driver E. W. Isom A. J. Koeving, Jr. H. P. Lanke Ima' D. W. Lrmer C. B. McKay G. H. Taber, Jr. L API 06904 I INTRODUCTION OF NEW MEMBERS AMD GUESTS The new member, Dr. W. W Brooks; the new associates, Mr. A. E. . ley, Mr. H - w * Field> 611(1 Mr. M. Fischer; and the guests, Mr. R. C. 2, ur. Marshall Clinton, Jr., Professor Philip Drinker, and Dr. F. F. Heyroth, recognized. tion II MINUTES OF PREVIOUS MEETING The minutes of the previous meeting, April 28, 19^7, were approved as circularized by D. V. Stroop. III REPORT OF SUBCOMMITTEE ON CARCINOGENICITY - DR. Me TVER WOODY. CHAIRMAN The report of the Subcommittee on Carcinogenicity was presented and is given in full in Appendix A. _ Dr. F. F. Heyroth of the Kettering Laboratory of Applied Physiology, University of Cincinnati School of Medicine, presented a progress report on the experimental carcinogenic studies that they are carrying out on several petroleum samples for the API. His report is given in full in Item k of Appendix A. Mr. H. G M. Fischer discussed the carcinogenic problem and outlined the activities of the Technical Advisors of the API Subcommittee on Carcinogenicity. The report of the meeting of the Technical Advisors held on October 13 and October lk, 19k7, and a letter from Mr. H. G. M. Fischer, dated November k, 19k7, to the Technical Advisors of the API Subcommittee on Carcinogenicity, relative to this problem are given in full in Appendix B . Action In receiving the subcommittee's report, the Medical Advisory Committee voted to adopt the following recommendations: 1. That the initial work and cost of the physical and chemical studies on various petroleum samples of interest to this committee should be carried out by the laboratories of the various petroleum companies represented on the committee. 2. That an epidemiological survey concerning cancer in the petroleum industry should be made by individual companies according to a common plan of procedure, under the coordination and guidance of some institution equipped to manage, adviee and interpret the results obtained. 3. That the API make the neceseary arrangements with some wellrecognized institution to secure the full-time services of a trained ecier-viet to work on the carcinogenic problems under consideracin by the AFI Kedical Advisory Cojanittee. k. That the Medical Advisory Committee request an appropriation of $25,000 to cover the first year of the rrogram described under Items 2 and 3 above, with the understanding that larger amounts in the order of $50,000 will be required in succeeding years. API 06905 -3- 5. That all companies having experimental data concerning the carcinogenic problem should make this data available to the committee in order that future experiments on this problem can be planned more intelligently. IV REPORT OF SUBCOMMITTEE ON CUTTING FLUIDS - DR. B. B. REEVE. CHAIRMAN The report of the Subcommittee on Cutting Fluids vas presented and is giren in ful1 in Appendix C . tion --- In receiving the subcommittee's report, the Medical Advisory Committee voted to adopt the following recommendations: 1. . That the literature survey* on Cutting Fluid Dermatitis should be accepted as presented. 2. That no research program be inaugurated until a more promising lead of approach is found. The survey recommendations are not concrete and are not specific for cutting fluid dermatitis. 3. That animal experiments do not appear feasible at this time. k. That the literary survey on cutting fluid dermatitis should be kept up-to-date and supplemented by an active file maintained on clinical reports. , 5. That emphasis should be placed, at least for the present time, on prevention rather them the research approach of cutting fluid dermatitis. 6 . That composite information be accumulated on prevention of cutting fluid dermatitis in the form of an API bulletin, to be made available to Industry through the..members of the API. It was the understanding of the committee that Mr. Bonsib would prepare the necessary material. Dr. L. C. Beard made the following recoranendation which was also adopted (See Appendix D for details): That the secretary, after checking with D. V. Stroop, should request Harvard University to publish in the technical literature the paper "Dermatitis from Cutting Cils" after suitable editing. V REPORT OF SUBCOMMITTEE ON FLUORIDES - DR. A. E. HOAG, CHAIRMAN The report of the Subcommittee on Fluorides vas presented to the conmittee and is given in full in Appendix E. (* "Dermatitis from Cutting Oils - A Critical Review" was prepared under the auspices of the Subconanittee on Cutting Fluids of the Medical Advisory Committee of the American Petroleum by Mr. Bertrand C. Kriete, under the direction of Marshall Clinton, M.D., of Harvard University.) API 06906 -k- The report vas received and adopted "by the committee. It was the consensus that the future work of the subcommittee will consist in obtaining from the University of Cincinnati, where work on the toxicity of fluorides is being carried out under the sponsor ship of the API and certain industrial groups, reports on the toxicity of fluorides and in arranging for the distribution of forthcoming reports from this laboratory so that the information may be readily available to the members of the API Medical Advisory Committee. VI OF SUBCOMMITTEE ON PERMISSIBLE CONCENTRATIONS - UR. V. C. BAIRD, CHAIRMAN The report of the Subcommittee on Permissible Concentrations was ^seated and is given in full in Appendix F. Action ----- In receiving the subcommittee's report, the Medical Advisory Comaittee voted to adopt the following recommendations: 1. That the preparation of toxicological reviews will be continued at Harvard University under the direction of Professor Philip Drinker. The subjects of these reviews should be the remaining compounds named on the original list prepared by the Medical Advisory Committee. (See Minutes of Meeting of November 16, 19^5.) Professor Drinker agreed to provide the members and associates of the committee readily available Information on particular substances as requested. 2. That Professor Drinker should represent the committee at a meeting of the Association of Governmental Industrial Hygienists in Boston in the Spring, at which time maximum allowable concentrations of certain substances of interest to the petroleum industry will be discussed. (See Appendix F"for full details.) 3. That the designation "API Toxicological Beviews" should be retained Instead of using some other designation. That $10,000 should be appropriated to Harvard University to continue the work of Professor Drinker and associates for the period April 1, 19k8 to April 1, 19^9. Professor Drinker plans to continue preparation of toxicological reviews and to initiate a screening test program approved at the committee's meeting on April 28, 19^7. 5 That all members should submit to the committee, prior to April 19^8, any new compounds on which they require toxicological reviews or screening tests. It vae the consensus of the committee that the work at Harvard University under the direction of Professor Drinker should continue for three years or more, and should include: . (a) Literature surveys on compounds recommended by the ccmalttee. API 06907 (b) Investigation by means of screening tests on certain compounds on which the committee feels more information is needed. (c) Other such research problems as may be authorized by the committee from time to time. It vas the consensus of the committee that trade names should not be , m the title of the toxicological reviews, except in certain cases where the u^^iC&l name of the compound vas given and the trade name was added because it c rved to identify the compound to a large number of people. vn T OF SUBCOMMITTEE OK MEDICAL POLICIES AND PRACTICES-ER. B.A. JEWETT. CHAIRMAN presented The report of the Subcommittee on Medical Policies and to the committee and Is given in full in Appendix G. Practices was Action In reviewing the subcommittee's report, the Medical Advisory Committee voted to adopt the following reconmendatlons: 1. That copies of the booklet, including questionnaire, "How Do We Bate" put out by the National Association of Manufacturers should be procured and sent to all members of the Medical Advisory Committee. Members should be requested to fill out the questionnaire and to return it to the chairman of the Subcommittee on Medical Policies and Practices. 2. That a mailing list of all petroleum companies having some form of medical service should be made up, with the idea of obtaining information from them and of disseminating to them information about medical policies and practices, as prepared and adopted by the Medical Advisory Committee. 3. That each company represented in the African' Petroleum Institute should be requested to develop a procedure for the employment and rehabilitation of handicapped veterans and also a procedure for assisting the handicapped employee. U. That it is good medical practice to administer tetanus toxoid to certain employees subject to occupational injuries. 5. That in addition to keeping mortality statistics as approved by the committee in a past meeting, morbidity data also should be kept. The use of standard nomenclature should be employed. 6 , That a clearing house should be established for the collection and dissemination of data on medical policies and practices of oil companies. This is to be carried out in accordance with the counsel and advice of Mr. Stroop. It was voted to refer back to the subcommittee for further study the following recommendation: That the subcommittee's report on Tours which was approved by the Subcommittee on Medical Policies and Practices and given in the API 06908 -6- Minutes of the Meeting of November 1^, 19^6, be adopted. Appendix C in Minutes of Meeting of November lU, 19^6.) (See ' tion: The committee voted against the adoption of the following recommenda- That articles for company magazines or house organs should be written by each subcommittee outlining the work done or being done, insofar as it is practical. (See Appendix G for details.) The committee voted to accept the following recommendation made by py V. C. Baird (given in full in Appendix H ) : That the API Public Relations Committee should be requested to advise the Medical Advisory Committee at its 19^6 Spring meeting concerning what information relative to the activities of this committee should be brought to the attention of various petroleum companies and employees In these companies. VIII REPORT OF EDITORIAL COMMITTEE - gt. J. P. HOLT. CHAIRMAN The report of the Editorial Committee was presented to the committee , and is given in full in Appendix I. Action In receiving the Editorial Committee's report, the Medical Advisory Committee voted to adopt the following recommendation in the report: That before these toxicological reviews are published by the API, a committee should be appointed to get in touch with the Manufacturing Chemists' Association and discuss any differences that exist between the data given in these toxicological reviews and in similar reports prepared by the Manufacturing Chemists' Association. H NEW BUSINESS Hr. R. C. Page suggested that at future meetings of the committee some diversion in the form of panel discussions would be desirable. He recommended that the chairman of the Medical Advisory Committee consider the possibility of arranging a scientific program, utilizing outside medical experts, to be held at some convenient time during the course of the next meeting of the Medical Advisory Committee in November I9 U8 . Action The conmlttee voted to accept the above recommendation. Dr. V. C. Baird recommended that all meetings of the Medical Advisory CeasBittee and its eubconsaitteee be closed to si T persons except members, associates and invited guests. The committee voted to accept the above recommendation. API 06909 -7- HEXT MEETING It was voted that the next meeting should he held concurrently vith meeting of the American Association of Industrial Physicians and Surgeons. ^ chairman will inform the members of the committee in the near future as to ate and place of the meeting. the Approved: Mriver Woody, M.D. Acting Chairman J. P. Holt, M.D. Secretary " API 06910 For Information Only - Not For Publication APPENDIX A REPORT TO TEE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON CARCINOGENICITY ' Dr. Mclver Woody - Chairman November 13, 19^7 The Subcommittee on Carcinogenicity submits the following report: The subcommittee met on August 26th and September 9th, 19^7, and, at the request of the Chairman, Mr. H. G. M. Fischer called a meeting of the Technical Advisors on October 13th and lUth, 19^7. 2 The group of Technical Advisors was charged with the task of drawing up ` physical and chemical specifications that might serve to distinguish petroleum fractions that are carcinogenic from those that are not. A report covering the results of their first meeting has been accepted by the aubcommittee and a copy la attached hereto. In connection with this report the question was raised as to whether or not the work outlined should be carried out as a cooperative effort by the several companies Involved rather than farmed out to some central research laboratory under API sponsorship. It was the opinion of the subcommittee that the preliminary technique had beat be developed by the petroleum laboratories involved. It was felt, however, that the sootier a central laboratory could be selected the sooner it will be able to take over the burden of this work on a permanent basis. 3, Although it was assumed that this new program outlined by the Technical group would yield samples for animal testing at an early date, it is now evident that it will be some time before the screening tests have been developed to the point where a Judicious selection of samples can be made. 4. Dr. Heyroth reported on the progress of the experimental work being carried on at Kettering Laboratory of Applied Physiology, as follows: Thirteen groups of experimental animals, each composed of 20 male mice of C^H strain, were employed in the program for investigating the carcinogenicity of oils. Each of the eight oils submitted to the Laboratory was tested upon a separate group. The remaining five groups were used for gaining assurance as to the suitability of the technical methods and choice of strain of mice for the investigation. The mice of one group were subjected to weekly applications of water alone upon the skin of their backs In order to learn the incidence of spontaneous cutaneous tumors in mice of this strain. No tumors were encountered during a period of 62 weeks. A second group was subjected in a like fashion to weekly applications of a white oil, with a generally similar result. The remaining three control groups were employed to gain definite assurance that a known carcinogen -- 20-methyl cholanthrene -- would cause cancers in these mice. This carcinogen was applied to these groups respectively in the form cf (l) an approximately saturated solution In white oil, (2 ) a 0 .3$ solution in benzene and, (3 ) s 0.6$ solution in benzene. The solution in white oil Induced tumors in 12 of the 20 mice, the tumors appearing at various intervals between the 13 th and toth weeks. The 0.3$ solution In benzene led to the appearance of tumors API 06911 '' M ' n A (Cont'd) -2- ij animals between the 23rd and 31st weeks. The 0.6$ solution in benzene rise to tumore in 18 anlmale by the 23rd week. In all five groupe Numerous animals died from various causes, often before they had been Bubjected to a carcinogen for a long enough period for its action to become erident. Of the eight oile submitted by the committee, No. W -3632 gave rise to tumors in lk of the 20 mice by the 3 kth week, at which time the remaining 8ix had died of other causes without having developed tumore. The data guggest that the oil is intermediate in carcinogenicity between an 0.3$ and an 0 .6$ eolution of methyl cholanthrene in benzene. The nature of the tumore as malignant squamous cell carcinomas was established by histologic examination Although 12 of the 20 mice subjected to oil No. W-3631 had died without showing eigns of tumore by the 5 kth week, this oil is not devoid of carcinogenicity for six of the group developed tumors. The first appeared in the 30th week, and the other five after the kQth week. Fifteen of the 20 mice eubjected to oil No. W-363O died without tumore, and the remaining five are apparently free from tumors at the 62nd week. The remaining eix oils have given rise to no tumors, although the numbers of weekly applications have ranged in these groups from k6 to 6 2 . A more complete report is to be submitted when the animals now alive ahull have died and been eubmitted to pathologic examination. In view of these results Dr. Heyroth suggested that the following work might be advisable: t (a) Extension of the work with oil No. W -3632 to mice of other strains suitable for this type of work. The uee of mice of heterogeneous origin ie important because inbred strains are now available only in small numbers. In addition to Dr. Heyroth's above suggestion it wae believed that the following types of animal experimentation could be carried out profitably: (a) Effect of dilution on carcinogenic properties of hydrocarbons. (b) Apply known carcinogen to animals and remove periodically by washing. (c) Effect of limited number of applications. (d) Application of a carcinogen at several separate sites in what ie believed to be sub-threehold amounts with the object of learning whether or not the amounts absorbed may summate to produce a cancer in any internal organ. As a result of a discussion of the literature survey on occupational cancer prepared under Dr. Drinker's direction,it was recommended that an epidemio logical survey of the petroleum industry be made by individual companies according to a common plan and procedure, all of which would be under the coordination and guidance of some institution equipped to manage and advise l -- API 06912 A (Cont d) -3- vae recommended that the API make necessary arrangements with some well 1` l c0gniaed institution to secure the full time services of a trained ^ientiet to work on the carcinogenic problems under consideration by the j(pl itedical Advisory Committee. Tt was recommended that the Medical Advisory Committee request an 8. __ropriation of $25,000 to cover the first year of the program described * L er item six and seven above, with the understanding that larger amounts, ln the order of $50,000, will be required in succeeding years. :: API 06913 For Information Only - Sot For Publication APPENDIX B November k, 19k? Please address reply to the writer at Standard Oil Development Co. Room 717, 26 Broadway New York City tbe Technical Advisors of the subcozoflittee on Carcinogenicity and G u e sts Gentian11 ! Attached is copy of my letter dated November k, 19k7, to Dr. Mclver Woody, transmitting minutes of our meeting on October 13 and lk. You will note the minutes have been modified in accord with suggestions received from tcae of you. Other items that require further consideration are the following: 1 . There appears to be a divided opinion concerning the substitution of a Vacuum Distillation Test for the ASTM procedure as outlined under Item A. Messrs. Zuidema and Warrick feel that the procedure might be qualified by retaining the ASTM test as stated and that, if cracking is observed before the 700F. vapor temperature is reached, the sample be subjected to further investigation. I am inclined to question our ability to properly specify the "cracking" point and also its reproducibility by the ASTM procedure. I shall send you a copy of the simple Vacuum Distillation Test as proposed in my letter of October 1 and shall leave it to your Judgment to decide what you want to do with it. 2. Concerning the choice of alpha methyl naphthalene, Dr. Beard has expressed the view that it is not available in a pure state. This was recognized when we discussed the matter and, as stated in the minutes (Page 7 ), Mr. Priestley was delegated to develop source and purity of this and other possible solvents. Furthermore, I have written to Dr. J. P. Holt and have asked him whether alpha methyl naphthalene is a satisfactory solvent from a medical viewpoint. Pending the classification of this item, I believe we should adhere to our original proposal. Dr. Beard recommends as a possible substitute orthoxylene, which has a boiling point of lkkC. (292F.) as compared with alpha methyl naphthalene, whose boiling point is approximately k72F. 3. Mr. Levin has suggested that, on Page 6 , Item k be added to the list of samples to be submitted for further tests; namely "Heptane Insolubles dissolved in alpha methyl naphthalene." You will recall that we discussed this matter at our meeting and decided for the time being not to Include this material in our list of samples for further testing (admitting that it may be an active material) until we knew more about its composition. This Is covered in Item D, Page 6 , which states that "....any material precipitated out will be separated and retained for further investigation." I would suggest that we first determine whether any such material is precipitated, and second, establish by analysis what its composition is, before we list it as an ear-marked sample for further investigation. API 06914 B (Cont'dl) -2- 4. Mr. Zuldema suggested that Item A be amplified to explain, more clearly why the 700F. cut point was chosen. You will recall that we had decided not to refer in the minutes to any biological tests and, therefore, reference to this property was omitted. I am sure that all those who attended the meeting are aware of the reasons for stipulating the 700F. cut point, and unless I receive further comments supporting Mr. Zuidema's suggestion, I would prefer to leave the item as written. 5 , As to Dr. Beard's question whether this investigation should be under taken as a cooperative effort by the individual laboratories or should be farmed out and paid for through API Research, I believe my comnents in the attached letter to Dr. Woody are self-explanatory. It may be possible for us to get together for a discussion of the above terns while at Chicago. If not, I shall appreciate hearing from you at your early convenience. Very truly yours, SGMF:BG Dr. J. P. Holt Standard Oil Co. (N.J.) Medical Department 30 Rockefeller Plaza /s/ H. G. M. Fischer H. G. M. FISCHER API 06915 -3- November U, 19^7 Please address reply to the writer at - Standard Oil Development Co. Room 717, 26 Broadway New York k, New York ifciver Woody I d ie a l Department Standard Oil Co. of 6 Broadway jew York City N.J. ear Dr. Woody: By way of your letter of September 10, 19^7, you, as chairman of the Afl Subcommittee on Carcinogenicity, authorized me to call together the group 0f technical advisors for the purpose of drawing up physical and chemical specifications that might serve to distinguish petroleum fractions that are carcinogenic from those which are not. You also requested that the group of advisors "determine what refining processes produce such fractions and what samples should be obtained for further study and investigation." You expressed the hope that a progress report might be available for incorporating in your Subcommittee's report to be presented at the November aseting o f the A P I. I am submitting the following review in response to your request. A meeting was held in the API board room, New York City, on October 13 and lU. Attendance and recommended action are recorded in the attached minutes. A rough draft of the minutes was sent to all participants for review. Approval or suggested changes have been received from the majority. Such changes as are not in conflict with matters actually discussed have been made, and I am submitting the minutes in the belief that they properly reflect the consensus of the group. I doubt that your conmittee will wish to concern Itself with the technical details; however, your carnalttee's approval is solicited of the general approach which the advisors group proposes to follow; namely, first to establish a reliable and reproducible method for concentrating and separating those fractions containing or consisting of high molecular weight, condensed ring hydrocarbons. This approach appeared to the advisors group as an essential first step toward the desired objectives. You may wish to have your subcansnlttee act on this matter at the Chicago meeting. In this connection, I wish to call attention to a rather fundamental question posed by Dr. L. C. Beard, Jr., who regrettably was unable to attend the meeting of the advisors group. Dr. Beard commented on the minutes in his letter of October 27, 19^7, from which I quote: "One thing in the proposed method of attack worries me somewhat and that is the duplication and drain on our already over-taxed technical personnel, entailed in this cooperative work. The purpose of API Research is to relieve individual laboratories of the individual burden of working on problems in wich there is a oc o m m i ty of interest. It appears to us that it might be cheaper to us individually if this work could be fanned out and paid for through Research. I recognize clearly the need by any such procedure of keeping the API 06916 ijX B (Cont'd) -k- .ul* 0 of such investigations strictly confidential, be given to this aspect of the natter." I think some consideration In view of the possibility that Dr. Beard's proposal (if accepted) ^ter the course contemplated by the advisors group, as outlined in the' vii1 bed minutes, a decision by your committee would appear to be pertinent. I an planning on attending your Chicago meeting and shall be available 0jcplain in greater detail the subject under consideration, if you so desire. Very truly yours, draff1:HC "7. Technical Advisors of the ' API Subcommittee on Carcinogenicity. /s/ E. G. M. Fischer E. G. M. FISCEER 1 API 06917 MINUTES On October 13 and Ik, 19^7, a meeting of the Technical Group of the dical Advisory Committee of the API was held in the API Board Boom, New York, I* The purpose of the meeting was to set up suitable procedures for the nation and analysis of high molecular weight, condensed ring, aromatic ^ocarbons which may be present in certain refinery streams and petroleum products. The attendance of regular members was as follows: Mr. B. S. Bonsib Mr. B. G. M. Fischer Mr. B. P. LankeIma Mr. E. B. Warrick Mr. B. E. Zuidema Standard Oil Co. (N.J.) Standard Oil Development Co. The Standard Oil Co. (Ohio) The Texas Co. Shell Oil Co., Inc. pr< L. c. Beard, Jr. of Socony-Vacuum Oil Company, Inc., was unable to attend. In addition to the regular members, the following guests were present: Dr. E. W. Adams Dr. F. P. Hochgesang Dr. J. P. Bolt Mr. B. Levin Mr. W. Priestley, Jr. Standard Oil Co. (Ind.) Socony-Vacuum Oil Co., Inc. (Substitute for Dr. L. C. Beard, Jr.) Standard Oil Co. (N.J.) The Texas Co. Standard Oil Development Co. Mr. H. G. M. Fischer acted as chairman in accord with authorization conveyed by Me Tver Woody, M.D., in a letter dated September 10, 19^7 Mr. W. Priestley, Jr. was appointed as secretary pro-tern. The procedure agreed upon for the separation and analysis of high Bolecular weight, condensed ring, aromatic hydrocarbons is summarized below: A. All samples will be screened by a simple distillation using the ASTW D158-U1 procedure. Those samples which have more than 2% boiling above 700F. will be submitted to further investigation. The 700F. cut point was based upon the boiling point of aromatics containing four or more condensed rings and was selected so as to eliminate compounds that are lower boiling than four ring structures. Samples which do not contain more than 2$ boiling above 700F. will not be investigated for the time being. B. If the residue boiling above 700F. from the ASTM distillation exceeds 2$, a second distillation will be carried out on the original oil (Material A ) , employing a Wldmer still at 20 mm. of mercury absolute pressure, to obtain a U00F.-700F.* fraction and a sufficient sample of 700F.* plus material for investiga-ion. The details of construc tion and operation of the Widmer column **..11 be supplied by Mr. Levin. ^ _______ API 06918 '* ^-bsoluto pressuro. Standardized method of conversion from boiling Points at 20 mm. to be stipulated.) B (Cont'd) -6- tf O * * C. On the residue obtained from the Widmer distillation (Material B), the following inspections will be obtained: 1. Specific gravity. 2. Molecular weight by the boiling point method employing C.P. benzene. 3. Melting point by ASTM method D97-39 or other suitable procedure. 4. Ultimate analysis for C, H, S, N. 0 by difference. 5 . Refractive index, and specific dispersion if the color permits. 6 . Bromine number. 7 . Kattwinkle test. E. The residue after Inspection will be separated into two fractions by silica gel percolation. Prior to the percolation, the residue will be dissolved in two volumes of normal heptane to one volume of sample. The mixture will then be centrifuged and any material perclpltated out will be separated and retained for further investigation. The liquid from the centrifuging operation will be put through a silica gel column for separation into aromatic and non-aromatic fractions. The details of the operation of the silica gel column will be supplied by Mr. W. Priestley, Jr. E. The non-aromatic fraction (Material C) from the silica gel percolation will be retained for further investigation if it appears desirable. The aromatic fraction (Material D) will, be Inspected in the Bame manner as the original residue (Material B ) . In addition, the ultraviolet spectrum of the aromatic fraction will be determined. A review of the ultraviolet spectra of condensed ring aromatics available in the literature will be made by Mr. W. Priestly, Jr. From this study, a specification will, be set so that if the ultra violet absorption is below a certain value at a specified wave length, the material under Investigation can be considered essentially free of four or more ring aromatics. F. The following samples will be submitted for further tests as directed by the Medical Advisory Committee : 1. Original (Material A ) . 2. Aromatic fraction (Material D) dissolved in 400-700F.** Vidmor still-cut of original oil, to give the same concentration* of the heavy aromatics as present in the original oil. 3. Aromatic fraction (Material D) dissolved in Alpha methyl naph.theQ.ene to give the same concentration* of the heavy aromatics as present in the original oil. - Alpha methyl naphthalene (B,P. 472F.) was chosen as a standardized solvent suitable for rendering soluble any difficultly soluble componente, end le preferred to benzene (B.P. 17F.) by reason of ____r * " * A higher concentration may also be investigated if found desirable.) (** At 760 am. absolute pressure.) API 06919 B (Confi) -7- The source and purity of alpha methyl naphthalene and other possible solvents, will be investigated by Mr. W. Priestley, Jr. q , In order to firm up the techniques outlined above, 5 gallons of a suitable oil to be known as API Sample 1-C will be supplied by the Standard Oil Development Company to each of the companies listed on Page 5 In transferring and storage of these samples, a blanket of oxygen-froe nitrogen will be used. Besults of theBe investigations will be forwarded tq Mr. H. G. M. Fischer for compilation. This compilation will show whether the procedure agreed upon gives reproducible results, and can be adopted or whether revision or modification will be required. H. All material not specifically ear-marked for inspection at this time should be retained for future investigation, If found desirable. The Standard Oil Development Company agreed to supply the following information: 1. A list of selected high molecular weight, condensed ring, aromatic hydrocarbons. 2. Inspections of the distillate and residual samples previously submitted by the API. 3. Sources of oxygen-free nitrogen. 4. The ultraviolet absorption technique. 5. Ultraviolet spectra obtained from the literature. Dr. E. V. Adams agreed to supply upon request, a sample of the 81-91$ fraction from hydrofanner bottoms for further testing. This fraction appears to be of Interest for establishing the possible existence of high molecular weight, condensed ring, aromatics in the 0- 90$ overhead cut from hydroformar bottoms. Mr. E. E. Zuidema agreed to supply, if available, the fluorescence ipectra of polycyclic aromatics. The possible use of Infra-red, Raman and Fluorescence spectra in this study was discussed. Jt was concluded that further investigations are required before adoption of thede optical methods can be recommended. The meeting adjourned at 1:00 p.m. on October lU, I9 U7 . Respoctfully submitted, /s/ William Priestley, Jr. William Priestley, Jr. Secretary API 06920 For Information Only - Not For Publication APPENDIX C REPORT TO THE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON CUTTING FLUIDS Dr. B. B. Reeve - Chairman November 13 19*7 omprehenBive literary survey on cutting fluids dermatitis has been made by * c jertrand C. Xriete of the Harvard University School of Public Health, a of vhich has been presented to the members of the Medical Advisory group, survey has completed as far as possible all of the recommendations .Lgested by the API Medical Advisory Coamlttee, as outlined in the report of iwj6subcommittee on Cutting Fluids, as presented at the Fifth Meeting held on April 28, 19*7. 1 . We recommend acceptance of the literary survey as presented. 2. Until a more promising lead of approach is found we reconaend that no research program be inaugurated. The survey recommendations are not concrete and are not specific for cutting fluid dermatitie. 3 . Animal experiments are not recommended as they do not appear feasible at this time. k. The literary survey on cutting fluid dermatitis should be kept up-to-date and an active file maintained on clinical reports. It is recommended by this ccenlttee, at least for, the present time, that emphasis be placed on prevention rather than the research approach of cutting fluid dermatitis. 6 . The subcommittee reconnends composite information be accumulated on prevention of cutting fluid dermatitis in the form of an API bulletin, to be made available to industry through the members of the API. // A. E. Hoag Robert C. Page H. R. WarricI F. F. Boys H. H. Zuidema F. M. Watkins E. W. Adams L. C. Beard, Jr. N. J. Gothard Thomas J. Kelly /s/ B. B. Reeve_______Chairman API 06921 For Information Only - Not For Publication APPENDI! D I. L. C. BEARD'S RECO*MENDATION ON MR. BERTRAND C. KRIETE'S REPORT ON "DERMATITIS PROM CUTTING O H S " The Harvard. University School of Public Health has prepared for tbe API M edical Advisory Consulttee and sponsored by API funds, a very cred itab le review of the technical literature on cutting fluid dermatitis. It le felt this report, suitably edited, should be published by the Harvard School of Public Health In the technical literature, with an acknowledgment to API support. Knowledge of the facts will assist Industry to a better understanding of this problem and to the prevention of dermatitis. Publication should also modestly assist API public relations by evidencing the Interest and expenditure of API funds In this respect. It Is moved that, after checking with Mr. Stroop as to the propriety, such request be forwarded to the Harvard School of Public Health by the secretary. API 06922 For Information Only - Not For Publication APPENDIX E REPORT TO THE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON FLUORIDES Dr. A. E. Hoag - Chairman November 13, 19^7 It was thought desirable at this time to briefly review the history ; jceoopliebmente and proposed plans of the Subcommittee on Fluorides. It will be recalled that in January 19^*6 considerable hysteria arose jjgat farmers and residents in the industrial regions of Southern New Jersey a"iative t0 iiie potential hazards due to hydrogen fluoride. A group of citizens f0 this area employed a consulting chemist In Philadelphia, who wrote a report such hazards, which was far from factual and added to the furor. Indignation fLtings were held and law suits initiated. A number of commercial plants, including both chemical plants and oil refineries were involved. Socony-Vacuum, while not directly Involved in these matters, but operating an HF alkylation plant at Paulsboro, New Jersey, undertook a systematic and complete study of the HF problem as related to public health and how an HF alkylation plant could be operated without hazard to animals, crops ar persons In i t s environments. These findings were made available to the API Medical Advisory Committee in a report of some fifty pages, which was distributed at a eetlng' of the API Medical Advisory Committee in November 19^6* At this same . nesting the Subcommittee on Fluorides was formed. Comments were solicited from the members of said subcommittee on the report, as well as any information that any of the members might have relative to the problem generally, The response to this request was not very productive. However, there were some questions raised on the plant physiological effects of HF, and in February I9 V 7 conversations were had with the Boyce Thompson Institute at Yonkers, New York, and the Information so obtained was made available to the embers of the subcommittee. Correspondence was also held with Dr. Marshall Clinton, Jr., on the problem generally, and at his suggestion a conference was held with Dr. F. C. Frary, Director of Research of the Aluminum Company of America regarding their experiences. Dr. Frary was found to be perhaps one of the best informed men In the world on this subject and the results of these conversations were made verbally available to the membership of the subcommittee at its meeting held in Buffalo on April 27, 19^7. At this same time, attention was directed to the existence of an industrial group sponsoring work at the Fettering Laboratories on the toxicity of fluorides. It was agreed in principle, subject to letter confirmation of the final proposals, that your chairman be empowered .to carry on negotiations with aid industrial group and with Dr. Robert A. Kehoe, directed to permitting the participation of the API Medical Advisory Committee in the work of the industrial group for a payment of $2,500 per year. API 06923 (Cont'cL) -2- These negotiations were carried forward and the industrial group their willingness for such participation and Dr. Kehoe presented a iK^gjtion in tki0 respect. This whole natter culminated in Mr. D. V. Stroop's proP_ October 3> 1947 to the members and associates of the Medical Advisory 7n substance this letter stated that unless comments to the contrary co8 b&d by October 27, he would advise Dr. Kehoe as per his attached letter API would implement participation in the work of the industrial group tb ^ pottering Laboratories by a contribution of $2,500 for the year 1947-1948. adverse ccsnments Stroop's proposition were received. Final acceptance -J.. Kehoe of the Institute's proposal mailed on October 28 has been received W 1 attached copy of Dr. Kehoe's letter of November 5, 1947 to Mr. Stroop. at P The future work of the Subcommittee on Fluorides, therefore, will be obtain from Dr. Kehoe copies of such past reports on the toxicity of fluorides aay be pertinent, and to arrange for the distribution of forthcoming reports o that the information can be readily made available to the members. While the situation in South Jersey has quieted down, yet interest in fluorides is increasing. U bs of &F and BF^ as catalysts continues. Vork on fluorisation has been stimulated by the development and sale of a laboratory fluorine generator; one company is marketing elementary fluorine l iron cylinders. As evidence of the interest in this field, 34 papers were presented &t a symposium on fluorine chemistry at the September 1946 meeting of the laerican Chemical Society and 11 papers were given at the last meeting in September 1947. Fluor-carbons have been used as very stable lubricants for special applications; one remarkable new plastic "Teflon" consists only of fluorine and carbon; fluorine has shown promise as an initiator of chlorination. Many other erang)les could be cited why work on the toxicity of fluorides should continue. At the subconmittee meeting held on November 12, 1947, the above report was accepted. In regard to the matter of reports, Dr. F. F. Heyroth of the Kettering Laboratories agreed to supply the chairman, for distribution to subcommittee members, with 10 copies of reprints of previous publications on their vork on fluorides and with 10 copies of their next {and first) annual report to the "industrial group." It was the sense of th meeting that the chairman should receive and distribute reports technical communications. /e/ A. . Hoag, Chairman API 06924 E (Cont'd) -3- UNIVERSITY OF CINCINNATI Cincinnati 19, Ohio taring Laboratory of Applied Physiology 0f Medicine - Eden Avenue CoU6* November 5, 1947 * rid V. Stroop Victor, Department of Safety J^rican Petroleum Institute {Twest 50th Street Jpv fork City 20 pear Mr- Stroop: Please accept my thanks for your letter of'October 28 which completely clarifies matters from my viewpoint, in relation to the contribution of $2,500 on the part of the American Petroleum Institute, toward the development of. information on fluorine and fluorine compounds (in accordance with our purposes aa restated in your letter), for the period of twelve months immediately follow ing your making of the contribution. I consider it entirely acceptable, that jou should reconsider this matter as you desire, from year to year. It so happens that I shall be at the meeting of the Medical Advisory Committee in the Hotel Stevens on November 12, at which time details related to this matter can be discussed. Meanwhile I am authorized by the industrial sponsors of the project to include your group among the sponsors. Therefore, this can be regarded as formal notification of the acceptance of your contri bution under the conditions set forth in your letter. Very truly yours, m ef ' Dictated but not read. C.C.: Mr. S. C. Ogbum, Jr. Dr. A. E. Hoag /s/ Robert A. Eehoe, M.D. API 06925  t I For Information Only - Not For Publication APPENDIX F REPORT TO THE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON PERMISSIBLE CONCENTRATIONS Dr. V. C. Baird - Chairman November 13, 191*7 (a) We submit the list of compounds given in the attached letter from Dr. Marshall Clinton, Jr. to Dr. V. C. Baird, on which toxicological reviews have been propared, for final approval and referral to the Editorial Committee. (b) A number of last minute changes concerning the above revievs have been taken into consideration by Dr. Clinton and have been incorporated in the final reviews that will be submitted to the Jjditorial Conmlttee. The work on the toxicological reviews will be continued at Harvard under the direction of Professor Philip Drinker on the remaining compounds given on the original list that was approved by the Medical Advisory Committee. Professor Drinker has agreed to provide readily available information on particular substances at the request of members or associate members of the API Medical Advisory Committee. Copies of such inquiries and replies should be sent to Mr. Stroop far distribution to all members of the conmlttee. A new list of tentative maximum allowable concentrations for various substances is being prepared by the Association of Governmental Industrial Hygienists for consideration-at their Spring meeting in Boston. Many of these substances are of interest to the petroleum industry. It is Professor Drinker's opinion that some of these proposed limits are unreasonably low. Professor Drinker has offered to represent the API Medical Advisory Ce m i t tee at the public meeting of this group. He proposes to circularize the Medical Advisory Committee stating which m a t Iu m allowable concentrations appear to be unreasonable, giving the evidence to support his views. If any member of the committee is in disagreement with Professor Drinker's views, and he expresses this by letter to Professor Drinker, no action will be taken on that {articular substance. The committee recommends that the designation, "API Toxicological Reviews" be retained. It is reconmended that $10,000 be appropriated to Harvard University to continue the ifcrk of Professor Drinker and associates for the period, April 1, 19WJ to April 1, 191*9* Professor Drinker plans to continue preparation of Toxicological Reviews and to initiate the screening test program approved at the conmlttee meeting in April, 191*7. API 06926 All members are requested to submit, prior to the April, 19 W , meeting, 1 any new compounds on which they require toxicological reviews or screening tests. 1 i It is anticipated that the work at Harvard under Professor Drinker will \ continue for 3 years or more and will consist of: 1 (a) Literature surveys on compounds recommended by the committee. < (b) Investigation by means of screening tests on certain compounds on which the cosmlttee feels more information is needed. (c) Other such research problems as may be authorized by the committee from time to time. 1 'i L API 06927 (Cont'd) -3- HARVARD UNIVERSITY SCHOOL OF PUBLIC HEALTH apartment of Industrial Hygiene 55 Shattuck Street Boston 15 Massachusetts October 29 19^7 v. C. Baird Oil & Refining Company post 2180 Office Box 1 gouston Texas Progress Report Pear Ur. Baird: The work being carried on at Harvard for the Subcommittee on Pemlssible Concentrations has proceeded during the period from May to November, despite my resignation from Harvard. . Corrected final reviews on the following twenty-two substances were distributed on September 8 19^7 in order to permit their consideration for acceptance as official reviews at the November meeting. These corrections Included all suggestions received up to the time they were sent to Mr. Stroop, but unfortunately do not Include a few additional comments received by us at a later date. These corrections were made subsequently on our copies however and can be Incorporated In the texts approved at the meeting. The title of the twenty-two reviews are as follows: Ditertiary butyl para Acetone Acrylonitrile Alkyl disulfides Alkyl Mercaptans Carbon monoxide Diethylene glycol Dowtherm A Hydrogen Fluoride Keroslne Maleic anhydride cresol Mercury , ' Methyl ethyl ketone Morpholine Naphthenic acids N-butyl P-amino phenol Phosphoric acid Phosphorous pentasulflde Silica Sulfur dioxide Thiophene and derivatives Thlophenol and the aromatic mercaptans In addition considerable other work has been accompli shed. A fairly detailed review on the status of Occupational Cancer has been prepared and distributed under the Joint auspices of the Subcommittee on Carcinogenesis and Permissible Concentrations. A detailed comprehensive review on Dermatitis due to Cutting Fluids was prepared under the auspices of the Subconmlttee on Cutting Fluids and eent to Dr. Reeve for approval. At Dr. Reeve's request, stencils are now being prepared on this review. Tentative drafts on phenyl naphthylamlne and U.O.P. #5 were also distributed. At present, literature survey information has been collected, but it has not been put into final form for distribution to the Medical Advisory Committee. This information consists of a number of substances. The question has arisen as to whether these are of sufficient interest to Justify the effort required to complete them, and whether any further literature survey work should API 06928 jj $ (Cont') 0 tei. It is the opinion of our two groups that the literature survey work he 8 3_ished so far, covering forty of the more Important substances, has ftC<5B^ted the cream of this work, and that further efforts along these lines may e*11" justified. It would perhaps be desirable for the API Medical Advisory lnlttee to decide whether any of the reviews on which data has been accumulated C < id be completed for distribution prior to the API meeting in the spring of Bba whether any further work along these lines should be undertaken. The 19*8' on which the available information has been compiled and which only ^ui r e a moderate amount of work for completion include the following- Tricresyl phosphate Barium chloride Barium hydroxide Barium nitrate Benzoldehyde Calcium chloride Calcium hypochlorite Hydrocyanic acid Pyridine Pi alkyl sulfates Nickel carbonyl Alkyl sulfuric acids Ethylene dichloride Mesitylene Alpha naphthol Tributyl phosphite Alkyl thloethere Triphenyl phosphate Nitroparaffins Alkyl peroxides Alkyl nitrates Amyl alcohol Carbon black Acetylene Cyclohexane- As already stated, we believe that further work on some of the above compounds is not Justified, while others should be completed before the next API Medical Advisory Committee meeting. An expression of opinion on this matter from the committee will be appreciated. If the committee desires, the work can be accomplished by collaboration between Dr. Clinton in Buffalo and ProfeBBor Drinker and hiB group at Harvard. Professor Drinker haB definite recommendations concerning the con tinuation of other phases of this work, which he will communicate to you. Very truly yours, /b/ Marshall Clinton Marshall Clinton, M.D. */F API 06929 -5- HAHVARD UNIVERSITY SCHOOL OF PUBLIC HEALTH pepartmcnt of Industrial Hygiene 55 Shattuck Street Boston 15 Massachusetts October 27, 19^7 Marshall Clinton diversity of Buffalo School of Medicine Buffalo, Nov York Pear Dr. Clinton: The substances vfaich I mentioned in my last letter are all completely written up now. I have begun to work on the following list of substances: Aniline & hamologs . ' Anthracene Chromate salts Methyl Chloride Naphthalene Naphtha light Naphtha solvents B-Naphthol Sulfur Trioxide Trichlorethylene On completing reports on the above, I intend to start work on these substances: Acid, acetic Alcohol, Butyl Alcohol, Propyl Freon Hydroquinone Lead oxide' Lead Sulfide Mesityl Oxide Methyl Cyclopentane Methyl Cyclohexane Triethanol amine Sincerely yours Dorothea K. Lear Philip Drinker API 06930 N Fnr information Only - Rot For Publication APPENDIX G REPORT TO THE API MEDICAL ADVISORY COMMITTEE BY THE SUBCOMMITTEE ON MEDICAL POLICIES AND PRACTICES Dr. R. A. Jewett - Chairman 1 . Supplementlog the original questionnaire made up from the questions asked at the first meeting and turned over to this canmittee for recommendation, It Is recomnended that the booklet "How Do Ve Rate,*1 put out by the National Association of Manufacturers, he procured and sent to all the members of the Medical Advisory Committee, filling out the questions *rvi then to be returned to the chairman of the Subcomnlttee on Medical Policies and Practices. 2. The subcommittee recomnends that a mailing list of all petroleum companies having some form of medical service be made up vlth the Idea of obtaining from them and disseminating to them information about medical policies and practices as approved and authorized by the API Medical Advisory Committee. 3 . The subcommittee's report on Tours has been received. This report states that a rotation of shifts no oftener than every two to three t months Is desirable. Your subcommittee has approved this report and recommends It to you for adoption. U. Your subcommittee recomnends that each company represented In the American Petroleum Institute be requested to develop a procedure for the employment and rehabilitation of handicapped veterans and also a procedure for the handicapped employee. 5 . Your subcommittee recommends your approval on the routine lnnoculatlon of employees against tetanus. 6 . It Is recommended that, in addition to keeping mortality statistics as approved by the committee In a past meeting, morbidity data also be kept. The use of standard nomenclature should be employed. 7. Since more and more questions are being asked of your camnlttee and subcomnlttee concerning the collection of data on the policies and practices of other oil companies, it is recomnended that a clearing house be established for the collection and dissemination of such data. 8 . It Is recomnended that articles for company magazines or hoube organs be written by each subcomnlttee outlining the work done or being done insofar as It Is practical and In such simple language that the laity may understand; the first series to outline the work of the Medical Advisory Camnlttee and to be written by the chairman of the subcomnlttee; the first one to be written by the chairman of the Medical Advisory Comal ttee: (a) Organization of the camnlttee and why. (b) Work of the Subcommittee on Policies and Practices. API 06931 I (Cont d) -2- /c) Work of the Subcomittee on Permissible Concentrations. /) Work of the Subcananittee on Carcinogenicity. (e) Work of the Subcommittee on Cutting Fluids. ^ second series about the subjects considered and endorsed by the judical Advisory Committee, such as: (a) Value of preplacement and periodic physical examinations. (to) Value of prepaid medical and hospital care. (c) Value of periodic plant and office sanitary inspections. (d) Value of keeping morbidity and mortality statistics. (e) Time elapsing between tours from the health standpoint. List of questions submitted for anaverix since the last'meeting: 1. Methods of taking blood serology in the sales department areas; are * these done privately or by state laboratories? 2. Are chest X-rays done routinely and, if so, hov are they handled in * the field? 3 . Are electrocardiograms done routinely, particularly on executives and service personnel over fifty years of age? It. Are Wasserman's made routinely? 5 . What efforts are being made in the industry for thorough vision testing of chauffeurs, particularly in reference to night vision, field of vision and depth perception? 6. Is it advisable to use local doctors for periodic examinations, or to send a full-time company doctor to the scenes of employment to make these examinations? 7. Is it advisable to keep morbidity statistical data on the incidence of disease? If so, can reliable information be obtained when the employees are scattered? 8. Hov many treatments, if any, should be allowed to employees suffering from sickness or non-occupational injury located where dispensary, plant, and office service is available, without a direct cost to the employee? 9 What use, if any, is being made of musical programs by radio in offices and plants? 10. Are X-ray examinations of the lumbar vertebrae of new employees of value in rating future disabilities? API 06932 For Information Only - Not For Publication appendn h I November 13, 19^7 ^ 0#roATION: H ealth education Is an Important function of this canmittee. -There Is certain Information pertinent to the health and healthful working conlUtions of employees In the petroleum industry that is of interest to A tlli8 committee and to the petroleum industry. It is desirable that this T information be distributed to the petroleum companies represented in the I xPI and to the employees of these companies. It is recommended that ve ,-- I jolicit the advice of the API Public Relations Committee to advise us at For Information Only - Not For Publication APPENDIX I N Nevqulst, Chairman jjr- Advisory Committee November 13, 19^7 3MT Sir: A meeting of the Editorial Committee of the American Petroleum Advisory Committee vas held in Mr. D. V. Stroop's office on July laical P e n t at this meeting were: Institute 29, 19^7. Mr. D. V. Stroop Dr. M. N. Nevquist Dr. Marshall Clinton, Jr. Dr. J . P . Soit The purpose of the meeting vas to reviev arid approve the introduction tbe toxicological reviews prepared by Dr. Clinton, and to make editorial Erections of the finally approved toxicological reviews on: Aluminum Chloride Ammonia Benzene Boron Trifluoride Carbon Tetrachloride "Chlorex" Cresol Cumene Furfural Hydrogen Chloride Hydrogen Sulfide Iron Carbonyl Nitrobenzene Phenol Styrene Sulfuric Acid Toluene Xylene With the exception of a few minor editorial changes and modifications, the introduction and toxicological reviews were approved. These papers have been submitted to the Safety Committee of the Board of Directors of the American Petroleum Institute for approval and authorization for publication. It has been brought to our attention that Safety Data Sheets on many of the compounds listed above have been prepared by the Manufacturing Chemists' Association and that these reports are not in complete agreement with our toxicological reviews. Therefore, it is our recommendation that before these toxicological reviews are published by the API a committee should be appointed to get in touch with the Manufacturing Chemists' Association and discuss this problem. c. Nuibers: ^7. Baird, Vice Chairman * Marshall Clinton, Jr. M. N. Nevqulst (Ex-officio) D. V. Stroop Respectfully submitted, J. P. Holt, M.D. Chairman API 06934 Sot For Publication Copies from D. V. Stroop for Information of Members and Associates of API Medical Advisory Cornaittee September 16, 19^7 oOo Minutes of Meeting of Subcommittee on Carcinogenicity September 9, 19h7 A special meeting of the Subcommittee on Carcinogenicity vas held at 26 Broadway, Hev York City on Tuesday, September 9th, 19^7. Those present vere: Dr. T. M. Frank Dr. A. E. Hoag Dr. J. P. Holt Dr. T. J. Kelly Dr. M. S. Sevqulst Dr. Mclver Woody - Pan American Refining Corp. - Socony-Vacuum Oil Co., Inc. - Standard Oil Company (H.J.) - Shell Oil Company, Inc. - The Texas Company - Standard Oil Company of S.J. Dr. L. C. Beard, Jr, Mr. R. S. Bonelb Mr. H. G. M. Flacher Mr. D. V. Stroop - Socony-Vacuum Oil Co., Inc. - Standard Oil Company (H.J.) - Standard Oil Development Co. - American Petroleum Institute Dr. Robert Clinton Page, Mr. E. P. Lankelaa, and Mr. E. R. Warrick had written that they would not be able to attend. The minutes of the previous meeting were reviewed and amended ae follows: ~ ' Paragraph 1, (b), third line, "a co-carcinogen and" should be "a co-carinogen or". Paragraph 2, (a), sixth line, "to have at least a structure" should read "to have a structure" . In discussing heading Ho. 1, Mr. Fischer stated his reasons for recoamending animal tests to determine the effect of different concentrations of methyl-cholanthrene dissolved In benzol as against the effect of the same concentrations dissolved in white oil. He was Inclined to think that at least five concentrations should be tested so that two curves could be drawn, one shoving the effect of the concentrations in benzol and the other the effect of the same concentrations In white oil. Eeadlnge Ho. 3, 5 and 6 were discussed together and general agree ment was reached that the following questions should be Investigated: 1 - Effect of actinic rays on skin contaminated with the possible carcinogen. API 06935 -2- Not For Publication 2 - Effect of washing vlth soap and water, or seme other solvent, after application of carcinogen. 3 - The value of protective creams. U - Effect of varying the site of application by painting a given n-tTBfli at a different spot each tine. 5 - Effect of applying carcinogen for a certain number of tinea (12 weeksi), then discontinuing applications and waiting to see whether a papilloma develops later on. 6 - The advisability of securing the services of a full-tine research worker who could not only direct research on problems designated by the API, but also run tests for individual companies on samples submitted by them. 7 - It was agreed that It would be up to the individual companies to decide how nuch each company wants to do on Its own, with the understanding that they will be kept Informed as to the nature of the API work. . ti 8 - It was agreed that It would be desirable to keep discussion within the SuV.czanlttee on an Informal basis so that each member could express his opinions freely without committing the company he represents. These discussions would serve as a basis far the Subcommittee's formal report, which would be limited to recommendations based on facts, rather than on mere opinions. 9 - The next meeting of the Subcoxmlttee was set for 9 A.M., November 12th, at the Hotel Stevens In Chicago. i 10 - Toward the close of the meeting, agreement waa reached among those present that It would be desirable to appoint Mr. H. G. M. Fischer as Chairman of the Technical Group of the Subcoamittee, with the understanding that he would call the technical advisers of the committee together to draw up physical and chemical specifications that might distinguish fractions that are carcinogenic from those which are not. Then, to determine what refining processes produce such fractions and what samples should be obtained for further study and Investigation. Mclver Woody. M.D. CHAIRMAN L API 06936