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I Abstracts of Poster Sessions Applications of Measures of Cumulative Exposure to Assessing Air Pollution Health Effects D. E. Abbey, C. L. Euk, A. R. Magic. J. E. Hodgkin m a Unda Unimity, Lorna Linda, California A METHOD for assessing the health effects of long-term cumulative exposures to air pollutants or other environmental exposures i s proposed and illustrated using self-reported symptoms of chronic o b structive pulmonary disease (COP01 for a population of 7,343 non- makers. Using zip code b~ month. residence histories, and interpok e d exposure estimates from the network of California air monitoring stations, two alternative exposure indices were calculatedto estimate cumulative exposure Over an 11-yr period above different threshold levels for each of four pollutants. The indices were used with multiple logistic regression models to form doseresponse curves for relative risks adjustingfor covariates. The dose-response curves are used to illustrate how a determination of at what exposure amounts and threshold levels health effects, which are biologically and statistically significant, begin to occur. Statistically significant effects were noted for. total. suspended particulates, total oxidants, sulfur dioxide, and w i v e smoking. A dexription i s also given of how the indices are currently being used in a l@yrfollow-up of the study population. This follow-up study is utilizing data collected by the National Cancer InstitUtefunded Adventist Health Study and has mortality, cancer incidence, heart disease incidence, and change in self-reported COPD symptoms as outcomes. ~ m m u n i t y - k s e dPrevention of Childhood Lead Exposure R. H. Anen U.S. E.P.A.IO.R.0. Office of Acid Deposition, Environmental Monitoring and Q u a l i Assurance, Washington, D.C. EXPECTED PREVALENCE of childhood lead exposure was corn. puted and mapped using census data for an urban metropolitan area. An estimate of the number of children at risk was made using those demographic risk factors found IOcorrelate with elevated blood lead levels, according to indices set bv the Centers for Disease Control. a d findings d the second National Health and Nutrition Examination surwy. Neighborhood variations were examined along with overlays of elementary school otchment areas. Recent findings about the epidemiology of childhood lead exposure were used to identify key vir. iables. Advancer in research and development of biomarkers of absorption and in measurement of significant adverse outcomes related to school behavior and learning were summarized. along with recommendations on solving common community involvement and meth. odologiul problems. Expeaed community variation in exposure and absorplion form the basis for a pro& community-based prwention m a r c h program in ddined elementary schools. Chromosomal Abnormalities and Environmental Exposures in Acute Nonlymphocytic Leukemia M. M. Crane, M. J. Kuting, J. M. Tntjillo, 0. R. Labarthe University of Taar Health kiennCmta k h o d ob Public Health, Houston and M. 0. Andenon Hospital and Tumor Institute CHROMOSOMALABNORMAUTIs are present in h e mu10w d approximately 50% of newly diagnosed acute nonIyrnphatic leukemia (ANLU patients, but their etiologic significance, ifany, is unclear. The frequency d environmental exposures, gathered by questionnaire from patients or relatives. was cornpared in 127 newly diagnosed ANLL patients with marrow abnormalities (M) and 109 ANLL patients with cytogenetically normal marrow. Thm represented 73% of de novo patients treated at M. D. Anderson Hospital between 1976 and 1983. M patients were more likely than NN patients to: report cytotoxic treatment for prior medical conditions (Odds Ratio [OR] and 95% confidence intervals, adjusted for -age. sex. and other exposures by logistic regression 4.25 t1.38, -13.17); smoke cigarettes, OR 1.82 (1.02, 3.26); drink alcoholic -beverages. OR L91 (1.05, 3.48); and work at occupations with -possible exposure to mutagens, OR 3.59 (0.76, 17.13). No statistically significant associations between aneuploidy and use of other tobacco. avocational exposure to chemicals or exposure to animals were present. Associations between specific abnonalitie and prior cytotoxic theram (deletion d chromosome 7). smoking (ex- tra chromosome 8. inversionchromosome 16). and occupation at the time of diagnosis (translocation between chromosomes 8 and 21) were noted. No association between occupational expoxlm to benzene or ionizing radiation and the 6 most common chromosomal abnormalities in ANLL patients were noted. although these a m are known io be leukemogenic. Problems with interpreting t h above associations, including the high nonresponse rate. a high propoflion of surrogate respondents. and the large number of significance tens that were pedonned. will be discussed. These results are consistent with those irom previously reponed series. and suggest that tumor- -specific markers may be present for some exposures in this diwaw. Fish Consumption Habits and Body Burden Levels of Chlorinated Hydrocarbons in Wisconsin Sport Fish- V. B. Jones, H.A. Anderson, 1. P. Hanrahan, L ]. Section of Environmental and Chronic Disease E p i d e m b , Wisconsin Division of Health, Madison, Wisconsin SINCE the mid-1960s. when trout and salmon stocking program were initiated. there has been a resurgence of Great b k e s rpons f i s h ing in Wisconsin. In the early 19705. the Wisconsin bpanmmt d Natural Resources, havtng identified hazardous constituents in indu, trial water discharge, implemented a fish monitoring pcoenm. Chlor-