Document ZnZDmmd7ZLMGz9XRn7BLqED90

ftFU%-OHL BIOSEARCH, INC. p.o. box 8598 Philadelphia, Pennsylvania !9 10 1 t el ephone: (215) 848-4499 Submitted to: 3M Company 3M Center St. Paul , Minnesota 55101 Mate ri al : Sample Received: Date of Report: Test : Object of Test: Method of Test: Results: 3M Company - T- 395 December 6, 1975 March 4, 1976 Primary Eye Irritation Study - Rabbits To determine the degree of irritation, if any, which the subject material may produce when instilled into the eyes of albino rabbits. This test was performed in order to classify this material under the Federal Hazardous Substances Labeling Act. The methods employed in the testing, evaluation and in the grading of the test material are those described in Section 1500.42 - Hazardous Substances and Articles, Administration and Enforcement Regulations, Federal Register, Vol. 38, No. 187, P. 27019, 27 September 1973- The sample was used as supplied. Six healthy young adult albino rabbits were used in this study. 0.1 gm of the experimental material was instilled into the right eyes of the test animals while the other eyes remained untreated to serve as controls. The test material was washed from the eyes in 3 animals after 5 sec. with 200 cc of water and after 30 sec. in 3 animals with 200 cc of water The treated eyes were examined at 1,24,48 & 72 hrs. & 5 & 7 days following instillation of the test material into the eyes. Interpretation of the results was made in accordance with the grading system outlined in the "Illustrated Guide for Grading Eye Irritation By Hazardous Substances". The results of the tests are shown in the accompanying Table which covers each of the animals treated with the test material. 000090 3M Company - T-1395, Primary Eye Irritation Study. Conclusion : Based on the accompanying table, the sub ject material is not an ocular irritant within the definition of the Act-Reference: Section 1500.^2 (b) (1) (2) P. 27019 and requires no cautionary labeling with respect to that section. Karl L. Gabriel , V.M.D., Ph.D. Di rector 000091 TABLE 1 Grades for Ocular Lesions Material : 3M Company - T-1395, as supplied and washed after 5 seconds wi th 200 cc of Rabbit Number 1 2 3 1 Co 1 C 0 0 if 0 0k 0 02 Hours After Appicatin 24 Co 1 C 48 Co 1 C 0 0k 0 0k 0 0k 0 0k 0 0k 0 02 72 Co 1 C 0 0k 0 0k 0 02 Co = Cornea 1 -Iris C - Conjunctivae 5 Days Co 1 C 0 0k 0 0k 0 02 7 Days Co 1 C 0 0k 0 0k 0 02 000092 TABLE 1 Grades for Ocular Lesions Material: 3M Company - T-1395, as supplied and washed after 30 seconds with 200 cc of water. Rabbit Number 1 2 3 1 Co 1 C 0 06 0 0k 0 0k Hours After Application 2k Co 1 C 1*8 Co 1 c 0 06 0 06 0 0k 0 0k 0 0k 0 0k 72 Co 1 C 0 06 0 06 0 0 1 Co = Cornea 1 lris C = Conjunctivae 5 Days Co 1 C 0 06 0 06 0 0k 7 Days Co C 0 06 0 06 0 04 000093