Document ZnYj0pNoYmveQeDaNya2R81q0

Taft/ Taft Stettinius & Hollister LLP 4 2 5 W alnut Street, Suite 1 8 0 0 /Cincinnati, OH 4 5 2 0 2 -3 9 5 7 /Tel: 513.381.2838 / Fax: 513.381.0205 /www.taftlaw.com Cincinnati / Cleveland / Colum bus / Dayton / Indianapolis / Northern Kentucky / Phoenix / Beijing Robert A. Bilott 513.357.9638 bilott@tafUaw.com February 16, 2009 f f'X'- cooV ootB7T TSCA Confidential Business Information Center (7407M) EPA East - Room 6428, Attn: Section 8(e) & FYI U.S. Environmental Protection Agency 1200 Pennsylvania Avenue, NW Washington, DC 20460-0001 o KJO Re: Submission To TSCA 8(e)/FYI Database Re: PFOA/PFOS To TSCA 8(e)/FYI Database: PO cO We are hereby providing the following information for inclusion in the TSCA 8(e)/ FYI databases with respect to PFOA/PFOS: 1. West Virginia University, "C-8 Health Project Results: C-8 And Other Laboratory Values (Tabular Format - Updated) (Feb. 2009). RAB:mdm Enclosure II!I!MlIHI il l! il 11339465.1 f kii'at: contains no cat  ^ Girls (Female, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 1 Girls (Female, <18Y0) Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Stdi Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation A-G Ratio (Final Recoded Value) AFP Tumor Marker, Serum ( ng-mL) Albumin, Serum ( gdL) Alkaline Phosphatase, Serum ( IU-L) Antinuclear Antibodies Direct ( ALT (SGPT) ( IU-L) U-ml) AST (SCOT) ( IU-L) 1.63 1.60 0.23 1.65 1.60 0.24 1.62 1.60 0.23 3.30 2.00 10.49 2.73 2.00 7.98 2.33 2.00 2.87 4.54 4.50 0.28 4.57 4.60 0.27 4.58 4.60 0.27 174.56 139.00 103.88 180.67 162.00 97.45 192.98 188.50 102.21 16.89 15.00 17.46 16.63 15.00 9.82 17.54 15.00 12.86 27.32 23.00 19.81 27.63 23.00 29.73 30.44 26.00 25.29 22.35 21.00 8.95 22.89 21.00 7.78 23.60 22.00 8.27 1.65 1.60 0.24 3.60 2.00 25.53 4.61 4.60 0.28 194.70 201.00 103.39 18.23 15.00 16.79 28.49 25.00 18.25 24.36 23.00 10.47 1.66 1.60 0.23 1.64 1.60 0.24 1.66 1.70 0.24 1.67 2.55 2.00 8.15 2.96 2.00 10.39 2.55 2.00 4.87 2.28 4.60 4.60 0.25 4.61 4.60 0.27 4.61 4.60 0.27 4.64 195.57 198.00 102.94 201.86 195.00 135.74 201.64 197.50 114.60 216.00 16.77 15.00 8.97 16.49 15.00 7.04 16.78 15.00 10.31 16.44 29.31 25.00 20.96 30.23 26.00 36.06 30.82 26.00 20.31 29.02 24.29 22.00 15.65 23.77 23.00 6.75 24.46 24.00 7.19 25.18 1.70 2.00 4.60 222.50 15.00 25.00 24.00 0.21 1.49 1.68 2.19 1.70 2.00 0.25 4.64 4.60 95.45 207.16 216.00 6.24 16.62 15.00 16.53 31.38 25.00 8.44 25.01 24.00 0.24 1.69 1.70 0.23 1.65 1.26 2,24 2.00 1.21 2.70 0.26 4,68 4.70 0.24 4.60 98.61 204.23 216.00 97.56 195.95 7.53 17.02 16.00 6.24 16.93 51.44 29.07 25.00 18.55 29.32 7.54 25.08 24.00 7.13 24.01 1.60 2.00 0.23 10.13 4.60 0.27 196.00 106.88 15.00 11.19 25.00 27.76 23.00 9,14 2009 West Virginia University School of Medicine t Girls (Female. < 18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 3 Girls (Female, <18Y0) Population Decile Group ~ C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Total Std. Deviation Mean Median Std. Deviation Cancer Antigen (CA-125) { U-ml) 16.59 15.00 8.41 16.84 15.10 8.17 16.45 15.10 8.95 16.47 14.60 9.24 17.08 14.30 19.67 16.91 15.00 8.78 16.57 15.00 7.71 15.59 14.65 6.39 16.23 14.50 8.03 16.95 15.00 10.45 16.58 14.90 10.09 CEA ( ng-ml) 0.55 0.25 0.51 0.55 0.25 0.47 0.58 0.25 0.50 0.55 0.25 0.41 0.55 0.25 0.45 0.58 0.25 0.49 0.59 0.25 0.55 0.57 0.25 0.47 0.62 0.25 0.65 0.61 0.25 0.56 0.57 0.25 0.51 Chloride, Serum ( mmol-l) 104.07 104.00 1.89 103.94 104.00 1.95 103.84 104.00 1.95 103.87 104,00 1.85 103.64 104.00 1.93 103.58 103.00 1.98 103.53 104.00 1.91 103.46 103.50 1.90 103.60 103.00 1.94 103.20 103.00 1.97 103.69 104.00 1.94 Cholesterol, Total { mg-dL) 159.39 156.50 29.53 163.12 160.00 28.67 161.81 159.00 28.13 163.93 161.00 29.77 163.14 160.00 28.97 163.95 161.00 31.61 165.43 161.50 31.08 161.99 160.00 28.54 163.53 160.00 27.61 167.17 166.00 29.34 163.23 160.00 29.42 Cortisol ( ug-dL) 9.96 8.20 5.85 10.35 8.60 6.34 9.63 8.30 5.47 9.40 8.00 5.39 9.59 8.20 5.88 8.81 7,60 5.25 9.03 7.60 6.11 8.61 7.40 4.86 8.52 7.20 5.16 8.94 7.40 5.19 9.33 7.90 5.63 C-Reactive Protein, Quant ( mg-l) 1.69 0.50 4.80 1.46 0.50 2.60 1.65 0.60 3.49 1.63 0.40 5.52 1.58 0.40 7.10 1.90 0.50 6.26 1.56 0.40 4.82 1.50 0.40 3,79 1.46 0.40 4.15 1.41 0.40 4.35 1.59 0.50 4.83 Creatinine, Serum ( mg-dL) 0.67 0.70 0.15 0.67 0.70 0.14 0.65 0.60 0.14 0.65 0.70 0.14 0.64 0.60 0.15 0,65 0.60 0.15 0.65 0.60 0.15 0.63 0.60 0.15 0.63 0.60 0.16 0.64 0.60 0.15 0.65 0.60 0.15 2009 West Virginia University School of Medicine . Girls (Female, < 18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 2 Girls (Female, <18Y0) Population Decile Group 1 2 3 4 5 6 7 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std, Deviation Mean Median Std. Deviation Baso (Absolute) ( x10e3-uL) 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.03 0.00 0.04 0.03 0.00 0.05 0.02 0.00 0.04 0.03 0.00 0.05 0.03 0.00 0.04 0.02 0.00 0.04 Bilirubin, Direct ( Basos ( %) mg-dl) 0.23 0.00 0.43 0.25 0.00 0.43 0.23 0.00 0.42 0.27 0.00 0.44 0.27 0.00 0.45 0.29 0.00 0.45 0.30 0.00 0.47 0.26 0.00 0.44 0.29 0.00 0.46 0.28 0.00 0.46 0.27 0.00 0.45 0.10 0.09 0.05 0.11 0.09 0.06 0.10 0,09 0.05 0.10 0.09 0.05 0.10 0.09 0.05 0.10 0.09 0.05 0.10 0.09 0.05 0.10 0.08 0.05 0.10 0.09 0.06 0.10 0.09 0.05 0.10 0.09 0.05 Bilirubin, Total ( mg-dL) 0.35 0.30 0.22 0.40 0.30 0.31 0.35 0.30 0.21 0.36 0.30 0.24 0.36 0.30 0.22 0.35 0.30 0.24 0.36 0.30 0.23 0.36 0.30 0.25 0.38 0.30 0.27 0.37 0.30 0.25 0.36 0.30 0.25 BUN ( mg-dL) 11.77 11.00 3.15 12.02 12.00 3.26 12.05 12.00 3.14 12.01 12.00 3.12 11.94 12.00 3.28 12.23 12.00 3.02 12.44 12.00 3.49 12.57 12.00 3.36 12.26 12.00 3.00 12.33 12.00 3.11 12.15 12.00 3.20 BUN-Creatinine Ratio (Final Calcium, Serum ( Recoded Value) mg-dl) 18.76 10.03 17.00 7.20 19.09 18.00 7.34 19.62 18.00 7.65 19.55 18.00 7.44 19.73 18.00 8.00 20.28 19.00 7.66 20.47 19.00 8.43 21.34 20.00 8.36 20.79 19.00 8.14 20.62 19.00 7.84 19.96 18.00 7.82 10.00 0.36 10.03 10.00 0.36 10.04 10.10 0.36 10.06 10.00 0.35 10.05 10.10 0.35 10.08 10.10 0.37 10.09 10.10 0.35 10.10 10.10 0.34 10.10 10.10 0.36 10.13 10.10 0.33 10.07 10,10 0.35 2009 West Virginia University School of Medicine Girls (Female, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 4 Girls (Female, <18Y0) Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Eos (Absolute) ( Eos ( %) x10e3-uL) 2.33 2.00 2.14 2.42 2.00 2.23 2.53 2.00 3.58 2.46 2.00 2.50 2.43 2.00 2.07 2.46 2.00 2.43 2.44 0.18 0.10 0.17 0.18 0.10 0.17 0.20 0.10 0,38 0.19 0.10 0.20 0.18 0.10 0.15 0.19 0.10 0.19 0.19 2.00 2.34 2.33 2.00 1.98 2.57 2.00 2.84 2.49 2.00 2.24 2.44 2.00 2.48 0.10 0.19 0.18 0.10 0.17 0.20 0.10 0.28 0.19 0.10 0.18 0.19 0.10 0.22 Free Folates (Folic Acid), Testosterone, Estradiol ( pg-ml) Serum ( ng-mL) Direct ( pg-ml) 201.29 32.00 1414.40 114.37 24.00 948.63 62.36 22.50 307.18 98.60 24.00 652.21 65.45 23.00 555.40 119.86 23.00 1161.05 70.11 22.00 696.43 41.79 19.00 141.67 41.47 20.00 56.25 33.63 20.00 35.54 89.04 23.00 784.26 21.03 18.60 9.68 21.89 19.30 9.87 21.24 18.65 9.32 22.21 19.30 9.80 21.55 19.00 9.63 21.01 18.60 9.60 20.45 18.10 9.23 22.04 19.50 9.45 22.52 19.00 10.18 22,28 19.70 9.72 21.58 19.00 9.66 0.55 0.40 0.52 0.56 0.40 0.58 0.53 0.40 0.54 0.52 0.30 0.51 0.53 0.30 0.89 0.55 0.30 0.60 0.52 0.30 0.67 0,52 0.30 0.82 0.43 0.20 0.51 0.46 0.20 0.64 0.52 0.30 0.63 Pree Thyroxine Index (Final Recoded Value) GGT ( IU-1) 2.25 2.20 0.41 2.26 2.20 0.40 2.27 2.20 0.41 2.28 2.30 0.43 2.29 2.30 0.40 2.33 2.30 0.40 2.35 2.30 0.40 2.31 2,30 0.38 2.31 2.30 0.39 2.29 2.30 0.38 2.29 2,30 0.40 12.07 11.00 7.41 12.12 11.00 4.94 12.83 11.00 6.19 13.20 11,00 11.24 12.16 11.00 5.52 12.33 11,00 5.05 12.22 11.00 5.36 11.65 11.00 4.52 11.68 11.00 3.81 12.09 11.00 4.43 12.24 11.00 6.19 Globulin, Total ( gdL) 2.83 2.80 0.33 2.82 2.80 0.36 2.88 2.90 0.34 2.84 2.80 0.34 2.81 2.80 0.34 2.86 2.80 0.36 2.83 2.80 0.35 2.82 2.80 0.35 2.81 2.80 0.35 2.82 2.80 0.35 2.83 2.80 0.35 2009 West Virginia University School of Medicine Girls (Female, < 18YO) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Girls (Female, <18YO) Page 5 Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Total Std. Deviation Mean Median Std. Deviation Glucose, Serum ( HDL Cholesterol ( mg-dL) mg-dL) 89.53 88.00 19.76 90.33 89.00 18.79 90.84 89.50 18.43 89.24 88.00 11.33 90.77 89.00 18.57 90.30 89.00 13.47 90.05 88.00 12.24 89.40 88.00 13.96 89.51 89.00 14.26 89.95 89.00 13.12 90.02 89.00 15.87 50.15 49.00 10.91 51.09 50.00 11.76 49.78 49.00 11.30 51.35 51.00 11.83 50.93 50.00 10.81 50.45 49.00 11.62 51.76 50.00 10.91 51.42 51.00 11.12 50.04 49,00 10.36 50.92 50.00 11.14 50.77 50.00 11.21 Hematocrit ( %) 39.44 39.40 2.56 39.51 39.50 2.51 39.51 39.40 2.54 39.61 39.60 2.61 39.79 39.70 2.56 39.40 39.30 2.57 39.52 39.50 2.76 39.34 39.30 2.69 39.47 39.40 2.48 39.71 39.70 2.42 39.52 39.50 2.57 Hemoglobin { g-dL) 13.39 13.40 0.86 13.45 13.40 0.82 13.45 13.40 0.85 13.48 13.50 0.86 13.51 13.50 0.85 13.37 13.40 0.84 13.43 13.40 0.90 13.36 13.40 0.90 13.43 13.40 0.82 13.51 13.50 0.79 13.44 13.40 0.85 Immunoglobulin A, Immunoglobulin E, Qn, Serum ( mg-dL) Total ( lU-mL) 150.51 142,00 70.98 144.17 134.00 69.23 152.67 144.00 70.00 141.35 131.00 70.57 139.02 132.00 71.62 139.76 130.00 65.01 137.60 128.00 67.10 130.24 118.00 68.65 132.21 125.00 67.24 132.46 124.00 65.59 140.58 131.00 68.99 92.80 17.00 411.57 91.38 18.00 262.68 130.18 20.00 606.50 93.52 16.00 360.84 87.74 18.00 234.13 97.65 17.00 445.35 109.71 19.00 454.36 74.17 16.00 184.85 122.69 18.00 617.77 91.23 16.00 231.98 99.32 17.00 410.24 2009 West Virginia University School of Medicine Girls (Fumalo, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 6 Girls (Female, <18Y0) Population Decile Group -- C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Immunoglobulin G, Qn, Serum ( mg-dL) 1047.55 1035.00 227,28 1035.65 1012.00 238.17 1064.68 1055.00 227.86 1038.90 1023.50 237.94 1007.31 1005.00 215.10 1026.48 1007.00 227.99 1006.03 999.00 229.69 996.13 976.00 214.67 998.59 992.00 240.98 1001.52 987.00 237.23 1023.94 1010.00 230.81 Immunoglobulin M, Insulin, Fasting ( Qn, Serum ( mg-dL) ulU-mL) 126.98 118.50 55.67 130.59 121.00 58.20 127.56 119.50 56,70 128.03 115.50 62.64 134.20 126.00 66.81 134.95 124.50 61.29 129.68 124.00 58.26 124.73 116.00 55.96 127.57 116.00 59.48 126.33 116.00 58.97 129.22 120.00 59.43 22.20 13.70 29.86 19.89 12.30 24.32 20.76 12.40 31.56 20.65 10.90 33.02 19.29 10.90 29.09 19.08 12.00 27.90 19.23 11.40 25.26 18.15 11.85 20.41 17.16 11.60 19.92 19.96 12.30 28.07 19.70 12.00 27.33 Insuiin-Like Growth Factor I ( ng-mL) 338.49 337.00 145.68 322.62 310.00 139.22 301.68 279.00 141,31 317.05 308.00 141.43 304.51 285.00 146.99 291.09 281.00 134.66 302.31 295.00 142.89 282.54 264.00 140.40 296.63 269.00 148.86 281.67 266.00 135.61 305.17 292.00 142.64 Iron, Serum ( ugdL> LDH ( IU-L) 84.00 79.00 36.84 84.76 194.11 185.00 49,16 198.17 82.00 35.21 81.29 79.50 190.00 48.91 202.36 197.00 31.96 84.52 50.86 201.40 81.00 34.74 64.88 80.00 198.00 48.50 204.33 197.50 37.80 78.56 58.40 204.63 76.00 34.08 82.49 199.00 49.30 205.83 77.50 35.11 80.88 77.00 33.75 84.41 81.00 202.50 46.43 211.30 212.00 49.08 206.58 205.00 36.53 81.22 81.00 33.80 82.72 79.00 46.74 207.77 210.00 47.24 203.25 199.00 35.06 49.75 LDL Cholesterol ( Calculated) 86.13 84.00 25.30 89.01 87.00 24.26 89.09 87.00 24.01 90.21 88.00 25.25 89.38 87.00 25.92 89.45 87.00 25.32 90.91 89.00 26.95 86.92 85.00 25.99 90.18 87.00 25.04 91.26 90.00 24.88 89.19 87.00 25.31 2009 West Virginia University School of Medicine Girls (Female, <18Y0) Girls (Female, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 7 Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Lymphs (Absolute) ( Lymphs (% ) x10e3-uL) 34.66 2.47 34.00 9.56 34.45 34.00 8.60 33.98 34.00 8.95 34.65 2.40 0.77 2.47 2.40 0.74 2.48 2.40 0.77 2.51 34.00 9.11 35.17 34.00 9.19 34.62 34.00 9.30 2.40 0.76 2.58 2.50 0.81 2.59 2.50 0.77 35.27 2.60 35.00 8.76 2.50 0.76 35.52 35.00 9.11 2.63 2.50 0.82 35.42 35.00 2.58 2.50 9.49 35.53 0.83 2.66 35.00 2.60 9.40 0.87 34.88 34.00 9.14 2.55 2.40 0.79 Magnesium. Serum ( mg-dL) MCH ( pg) 2.01 2.00 0.14 2.03 2.00 0.14 2.04 2.00 0.15 2.04 2.00 0.14 2.04 2.00 0.14 2.04 2.00 0.14 2.05 2.00 0.14 2.08 2.10 0.15 2.07 2.10 0.15 2.08 2.10 0.14 29.61 29.70 1.65 29.69 29.70 1.51 29.53 29.60 1.58 29,57 29.60 1.53 29.42 29.50 1.68 29.34 29.40 1.58 29.48 29.50 1.54 29.32 29.40 1.58 29.40 29.40 1.48 29.41 29.40 1.46 2.05 29.49 2.00 29.50 0.14 1.56 MCHC ( g-dL) MCV ( fL) 33.96 34.00 0.62 34.06 34.10 0.60 34.04 34.10 0.64 34.04 34.10 0.58 33.98 34.00 0.67 33.95 34.00 0.63 33.99 34.00 0.60 33.96 34.00 0.62 34.02 34.00 0.58 34.02 34.00 0.58 34.00 34.00 0.61 87.22 88.00 4.44 87.22 87.00 4.09 86.77 87.00 4.19 86.93 87.00 4.21 86.61 87.00 4.42 86.46 86.00 4.32 86.78 87.00 4.31 86.36 86.00 4.36 86.47 86.00 4.09 86.47 86.50 4.13 86.75 87.00 4.27 Monocytes(Absoiute Monocytes ( %) ) ( x10e3-uL) 6.50 0.47 6.00 0.40 2.01 6.52 6.00 1.99 6.43 6.00 1.96 6.41 0.16 0.47 0.50 0.18 0.48 0.50 0.18 0.47 6.00 0.40 2.00 0.16 6.39 0.47 6.00 0.50 2.09 0.18 6.48 0.49 6.00 0.50 1.77 0.16 6.46 0.48 6.00 1.97 6.50 0,50 0.16 0.48 6.00 0.50 1.93 0.17 6.34 0.47 6.00 1.84 0.50 0.16 6.26 0.47 6.00 0.50 1.95 0.17 6.43 0.47 6.00 1.95 0.50 0.17 f" i 2009 West Virginia University School of Medicine Girls (Female, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 8 Girls (Female, <18Y0) Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Neutrophils {%) 56.29 57.00 10.29 56.36 57.00 9.59 56.83 57.00 9.89 56.21 56.00 9.99 55.74 56.00 10.00 56.15 57.00 10.09 55.53 56.00 9.66 55.39 55.00 9.93 55.38 56.00 10.28 55.45 56.00 10.31 55.97 56.00 9.99 Neutrophils (Absolute) ( x10e3- uL) 4.22 3.95 1.62 4.24 3.90 1.68 4.37 4.20 1.73 4.28 4.00 1.64 4.28 4.00 1.72 4.45 4.20 1.85 4.26 4.00 1.63 4.26 4.00 1.66 4.21 3.90 1.64 4.35 4.00 1.82 4.29 4.00 1.70 Phosphorus, Serum ( mg-dL) 4.48 4.50 0.70 4.55 4.50 0.74 4.54 4.50 0.71 4.60 4.60 0.69 4.62 4.60 0.80 4.58 4.60 0.69 4.62 4.60 0.73 4.73 4.70 0.80 4.69 4.70 0.77 4.76 4.80 0.73 4.61 4.60 0.74 Platelets { x10e3- Potassium, Serum uL) ( mmol-L) 316.99 311.00 4.14 4,10 75.48 314.45 309.00 69.87 323.85 316.50 0.29 4.09 4.10 0.28 4.10 4.10 74.48 317.09 310.50 70.09 0.26 4.12 4.10 0.27 316.82 311.00 74.00 321.65 315.00 4.09 4.10 0.30 4.11 4.10 72.34 317.47 0.29 4.10 312.00 69.76 321.27 313.00 72.29 314.32 310.00 70.30 322.56 319.00 73.97 318.54 312.00 4.10 0.31 4.10 4.10 0.30 4.12 4.10 0.31 4.12 4.10 0.27 4.11 4.10 72.28 0.29 Protein, Total, Prolactin { ng-mL) Serum ( g-dl) 10.95 8.20 13.83 10.58 8.50 11.75 9.86 8.10 8.56 9.78 7.80 10.65 9.52 8.15 6.27 9.94 7.70 14.24 9.58 8.05 10.19 8.80 7.60 4.88 9.19 7.80 5.80 8.96 7.30 5.30 7.37 7.40 0.40 7.39 7.40 0.44 7.46 7.50 0.41 7,45 7.40 0.41 7.41 7.40 0.41 7,47 7,50 0.43 7.44 7.45 0.43 7.46 7.40 0.43 7.45 7.40 0.42 7.49 7.50 0.42 9.78 8.00 10.05 7.44 7.40 0.42 2009 West Virginia University School of Medicine p. 10 Girls (Female, <18YO) Girls (Female, <18YO) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 9 Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean . Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation RDW ( %) 13.61 13.40 1.07 13.43 13.30 0.81 13.36 13.25 0.95 13.35 13.20 0.80 13.35 13.20 0.92 13.37 13.20 0.83 13.25 13.10 0.83 13.30 13.20 0.80 13.28 13.20 0.83 13.27 13.20 0.70 13.36 13.20 0.87 Red Blood Cell Count ( x10e6-uL) 4.53 4.55 0.30 4.54 4.54 0.31 4.56 4.57 0.31 4.57 4.57 0.32 4.60 4.57 0.32 4.57 4.55 0.32 4.56 4.54 0.30 4.56 4.56 0.31 4.57 4.56 0.29 4.60 4.60 0.30 4.56 4.56 0.31 Sodium, Serum ( mmol-L) 140.68 141.00 1.95 140.64 141.00 1.87 140.63 141.00 1.92 140.70 141.00 1.87 140.61 141.00 1.80 140.53 141.00 1.99 140.45 140.00 1.91 140.43 141.00 1.88 140.62 141.00 1.95 140.51 140.00 1.98 140.58 141.00 1.91 T3 Uptake ( %) 29.56 30.00 3.35 29.72 30.00 3.18 29.57 30.00 3.02 29.70 30,00 2.99 29.82 30.00 2.87 29.61 30.00 3,25 29.76 30.00 2.99 29.84 30.00 2.55 29.73 30.00 2.86 29.74 30.00 2.69 29.70 30.00 3.01 Testosterone, Serum ( ng-dL) 33.13 31.00 18.44 31.41 30.00 18.28 30.46 28.00 17.25 29.63 27.00 17.51 30.59 29.00 24.87 28.36 26.00 17.68 28.29 27.00 17.84 26.74 23.00 22.37 26.21 24.00 16.28 27.18 24.00 16.58 29.38 27.00 18.95 Thyroxine (T4) ( ngdL) 7.71 7.50 1.76 7.68 7.50 1.61 7.77 7.60 1.65 7.72 7.70 1.60 7.76 7.70 1.51 7.98 7.90 1.65 7.97 7.80 1.63 7.81 7.60 1.42 7.83 7.70 1.54 7.75 7,60 1.44 7.80 7.70 1.60 Triglycerides ( mgdL) 116.59 96.00 73.27 116.09 99.00 70.72 116.20 93.00 72.50 112.73 94.00 68.50 116.04 99.50 71.12 120.04 97,00 74.93 113.83 97.50 62.49 118.48 102.50 64.85 117.60 98.00 67.62 127.66 105.00 87.75 117,33 97.00 71.51 2009 West Virginia University School of Medicine p. 11 Girls (Female, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 10 Girls (Female, <18Y0) Population Decile Group -- C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Uric Acid, Serum ( TSH ( ulU-mL) mg-dL) 2.00 4.38 1.66 4.30 1.72 2.15 1.01 4.44 1.74 4.30 3.82 2.06 1.83 1.14 1.06 4.40 4.30 1.07 2.02 1.75 1.18 2.01 4.38 4.20 1.05 4.41 1.75 4.30 1.35 1.03 2.06 4.37 1.70 1.75 2.08 4.30 1.03 4.41 1.81 4.40 1.37 1.07 2.12 4.31 1.78 1.83 2.30 1.80 4.20 1.05 4.30 4,20 3.85 1.03 2.67 4.34 1.84 4.20 8.30 1.04 2.13 4.38 1.76 4.30 3.21 1.04 Vitamin B12 ( pgmL) 598.49 554.50 261.44 586.09 537.50 228.10 608.06 564.00 248.84 615.99 559,00 266.19 614.08 558.50 231.07 615.56 568.00 264.31 588.20 545.50 219.78 606.64 555.00 232.95 618.75 567.00 238.30 610.57 570.00 245.48 605.48 557.00 244.32 VLDL Cholesterol (Calculated) ( mg- dL) 22.80 19.00 12.71 22.60 20.00 12.14 22.71 19.00 13.22 22.19 19.00 12,54 22.65 20.00 12.99 23.03 19.00 12.68 22.77 19.50 12.52 23.53 20.00 12.54 23.17 19.00 12.49 24.29 21.00 13.39 22.94 19.00 12.71 White Blood Cell Count ( x10e3-uL) 7.34 7.10 1.92 7.38 7.10 2.06 7.55 7.30 2.15 7.45 7.10 1.98 7.53 7.20 2.09 7.74 7.50 2.16 7.54 7.30 1.97 7.56 7.30 2.06 7.46 7.30 2.01 7.69 7.40 2.20 7.52 7.30 2.06 2009 West Virginia University School of Medicine p. 12 Boys (Mele, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 11 Boys (Male, <18Y0) Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation A-G Ratio (Final Recoded Value) 1.89 1.70 3.62 1.71 1.70 0.23 1.68 1.70 0.23 1.72 1.70 0.23 1.71 1.70 0.23 1.70 1,70 0.24 1.71 1.70 0.22 1.72 1.70 0.23 1.71 1.70 0.23 1.72 1.70 0.23 1.72 1.70 0.95 AFP Tumor Marker, Serum ( Albumin, Serum ( g- ng-mL) dL) 2.06 4.59 2.00 4.60 0.96 0.29 2,06 4.62 2,00 4.60 1.12 0.26 2.08 4.62 2.00 4.60 1.29 0.25 2.14 4.66 2.00 4.70 1.25 0.25 2.09 4.63 2.00 4.60 1.23 0.25 2.06 4.63 2.00 4.60 1.00 0.25 2.05 4.67 2.00 4.70 0.91 0.24 2.14 4.66 2.00 4.70 2.22 0.25 2.11 4.66 2.00 4.70 0.91 0.24 2.14 4.68 2.00 4.70 1.21 0.25 2.09 4.64 2.00 4.60 1.29 0.25 Alkaline Phosphatase, Serum ( IU-L) Antinuclear Antibodies Direct ( ti ALT (SGPT) ( IU-L) ni L) AST (SGOT) ( IU-L) 247.07 247,00 84.46 245.82 241.00 120.76 241.96 233.00 20.27 17.00 13.05 20.79 18.00 17.43 19.66 17.00 25.17 22.00 12.76 27.98 23.00 40.84 28.52 23.00 26.76 26.00 8.38 26.87 25.00 12,86 26.25 25.00 121.39 10.50 25.44 8.64 235.14 227.00 104.31 20.70 17.00 13.41 26.39 23.00 16.48 27.57 27.00 11.97 243.59 239.00 99.32 239.76 237.00 93.03 250.03 244.00 142.46 246.07 242.50 93.88 246.18 238.50 94.08 244.01 241.00 90.63 19.81 17.00 11.21 20.13 17.00 11.52 19.59 17.00 10.40 19.47 17.00 10.42 19.44 17.00 10.47 20.01 17.00 11,22 29.14 25.00 29.75 31.24 24.00 58.96 29.84 25.00 28.25 28.91 26.00 15.23 27.50 24.00 21.65 28.00 24.00 15.70 26.37 25.00 7.04 26.31 25.00 7.32 26.89 26.00 7.27 26.95 26.00 7.73 26.89 26.00 6.78 27.10 26.00 7.24 244.04 19.98 28.45 26.79 239.00 17.00 24.00 26.00 106.91 12.16 30.71 8.78 2009 West Virginia University School of Medicine p. 13 Boys (Male, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 12 Boys (Male, <18Y0) Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Total Std. Deviation Mean Median Std. Deviation Baso (Absolute) ( x10e3-ul) Basos(% ) 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.03 0.00 0.04 0.03 0.00 0.05 0.03 0.00 0.05 0.22 0.00 0.41 0.27 0.00 0.44 0.27 0.00 0.44 0.26 0.00 0.44 0.30 0.00 0.46 0.36 0.00 0.49 0.34 0.00 0.49 0.03 0.00 0.05 0.03 0.00 0.05 0.03 0.00 0.05 0.03 0.34 0.00 0.48 0.36 0.00 0.49 0.32 0.00 0.48 0.31 0.00 0.05 0.00 0.47 Bilirubin, Direct ( mg-dL) 0.11 0.10 0.06 0.12 0.10 0.06 0.11 0.10 0.06 0.11 0.09 0.06 0.11 0.09 0.06 0.11 0.09 0.06 0.11 0.09 0.06 0.11 0.09 0.06 0.11 0.09 0.06 0.10 0.09 0.06 0.11 0.09 0.06 Bilirubin, Total ( mg-dL) BUN ( mg-dL) 0.40 0.30 0.26 0.43 0.30 0.32 0.41 0.30 0.29 0.41 0.30 0.31 0.41 0.30 0.31 0.39 0.30 0.28 0.40 0.30 0.30 0.41 0.30 0.32 0.39 0.30 0.26 0.39 0.30 0.31 0.41 13.01 13,00 3.26 13.12 13.00 3.45 13.39 13.00 4.46 13.36 13.00 3.41 13.35 13.00 3.46 13.40 13.00 3.33 13.56 13.00 3.42 13.39 13.00 3.48 13.32 13.00 3.30 13.39 13.00 3.47 13.34 0.30 0.30 13.00 3.53 BUN-Creatinine Ratio (Final Recoded Value) 20.26 19.00 8.46 19.63 18.00 7.75 20.04 19.00 7.46 20.72 19.00 8.32 20.73 19.50 8.33 20.60 19.00 8.05 21.16 20.00 8.83 21.10 20.00 8.63 21.09 20.00 8.47 21.05 19.00 8.79 20.65 19.00 8.33 Calcium, Serum ( mg-dL) 10.05 10.10 0.34 10.05 10.00 0.34 10.06 10.10 0.33 10.08 10.10 0.33 10.07 10.10 0.34 10.07 10.10 0.33 10.08 10.10 0.33 10.08 10.10 0.34 10.10 10.10 0.32 10.11 10.10 0.34 10.08 10.10 0.33 2009 West Virginia University School of Medicine p. 14 Soys (Mele, <18YO) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 13 Boys (Male, <18Y0) Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total 08 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Cancer Antigen (CA-125) ( U-mL) CEA ( ng-ml) 13.62 12.75 6.25 13.75 12.35 6.16 13.57 12.30 6.63 13.89 0.67 0.50 0.54 0.70 0.50 0.59 0.71 0.50 0.62 0.71 12,70 6.19 0.50 0.63 13.86 12.50 7.04 14.46 13.10 7.35 14.47 0.74 0.50 0.67 0.73 0.60 0.68 0.70 13.40 6.79 13.99 13.10 0.50 0.59 0.70 0.50 6.02 13.81 12.60 6.23 14.24 0.60 0.70 0.50 0.66 0.67 13.20 6.24 13.99 12.80 6.51 0.50 0.59 0.70 0.50 0.62 Chloride, Serum ( Cholesterol, Total ( mmol-L) mg-dl) 103.38 103.00 2.01 103.34 103.00 2.00 103.02 103.00 1.94 103.14 103.00 1.96 102.99 103.00 2.02 103.08 103.00 1.93 102,96 103.00 1.91 102.91 103.00 1.84 102.90 103.00 1.83 102.84 103.00 2.03 103.04 103.00 1.95 153.53 152.00 30.42 156.25 154.00 28.34 157.12 154.00 29.09 157.85 157.00 28.74 156.78 154.00 27.86 159.02 156.00 29.69 160.08 158.00 28.16 160.24 157.00 28.27 159.60 156.50 29.79 160.27 159.00 30.06 158.30 156.00 29.04 Cortisol ( ug-dL) 9.75 9.00 4.33 10.43 9.45 4.78 9.76 8.90 4.72 9.86 9.20 4.92 9.12 8.40 4.47 9.06 8.40 4.35 9.03 8.00 4.66 9.13 8.20 4.71 9.18 8.30 4.63 8.82 8.00 4.55 9.40 8.50 4.65 C-Reactive Protein, Quant ( Creatinine, Serum ( mg-L) mg-dL) 1.62 0.40 4.18 1.38 0.50 3.88 2.06 0.50 8.51 1,20 0.40 2.98 1.50 0.40 4.25 1.43 0.40 3.54 1.15 0.40 4.18 1.32 0.40 6.64 1.31 0.40 3.55 1.52 0.40 4.85 1.44 0.40 4.97 0.70 0.70 0.20 0.72 0.70 0.19 0.72 0.70 0.26 0.71 0.70 0.21 0.70 0.70 0.20 0.71 0.70 0.20 0.70 0.70 0.20 0.69 0.70 0.19 0.69 0.60 0.20 0.69 0.70 0.19 0.70 0.70 0.21 2009 West Virginia University School of Medicine p. 15 Boys (Mato, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 14 Boys (Male, <18Y0) Population Decile Group -- C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Eos ( %) 2.93 2.00 2.46 2.77 2.00 2.34 2.81 2.00 2,40 2.80 2.00 2.71 2.78 2.00 2.44 2.91 2.00 2.75 2.82 2.00 2.36 2.83 2.00 2.42 2.79 2.00 2.35 2.75 2.00 2.38 2.82 2.00 2.46 Eos (Absolute) ( x10e3-uL) 0.20 0.20 0.17 0.19 0.10 0.17 0.20 0.20 0.18 0.21 0.10 0.21 0.20 0.20 0.18 0.21 0.20 0.22 0.20 0.20 0.18 0.21 0.20 0.19 0.21 0.10 0.19 0.21 0.10 0.20 0.20 0.10 0.19 Free Folates (Folic Acid), Testosterone, Estradiol ( pg-mL) Serum ( ng-mL) Direct ( pg-mL) 16.86 16.00 9.19 16.26 16.00 9.24 15.31 15.00 8.84 15.08 14.00 9.01 15.37 14.00 8.71 16.10 15.00 8.70 15.12 14.00 8.81 14.46 13.00 8.57 15.38 15.00 8.08 14.99 14.00 8.52 15.45 15.00 8.78 22.11 19.25 9.65 21.67 19.20 9.52 21.91 19.00 9.81 21.62 18.85 9.44 21.33 18.45 9.48 20.96 18.60 9.13 21.36 18.50 9.17 21.52 19.15 9.38 22.58 19.10 9.58 22.74 19.60 9.65 21.76 19.00 9.48 4.63 3.00 4.88 4.78 1.95 5.34 4.53 1.10 5.45 4.57 1.00 5,70 4.47 0.90 5.63 4.67 1.30 5.80 4.19 0.60 5.66 4,01 0.60 5.30 3.99 0.60 5.48 3.78 0.40 5.16 4.35 0.85 5.46 Free Thyroxine index (Final Recoded Value) GGT ( IU-L) 2.18 2.20 0.39 2.17 2.20 0.39 2.19 2.20 0.41 2.21 2.20 0.41 2.20 2.20 0.39 2.21 2.20 0.38 2.24 2.20 0.39 2.27 2.30 0.39 2.26 2.30 0.45 2.22 2.20 0.39 2.22 2.20 0.40 14.82 13.00 7.80 15.72 13.00 14.31 15.34 13.00 9.61 15.50 13.00 8.69 15.31 13.00 8.93 14.92 13.00 6.15 14.70 13.00 8.04 14.62 13.00 6.93 14.45 13.00 7.01 14.69 13.00 8.08 15.01 13.00 8.92 Globulin, Total ( gdl) 2.73 2.70 0.36 2.74 2.70 0.33 2.79 2.80 0.33 2.74 2.70 0.32 2.75 2.70 0.33 2.77 2.80 0.34 2.76 2.70 0.33 2.76 2.70 0.33 2.76 2.70 0.33 2.76 2.70 0.33 2.76 2.70 0.33 2009 West Virginia University School of Medicine p. 16 Boys (Male, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 15 Boys (Male, <18Y0) Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total 08 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Glucose, Serum ( mg-dL) 93.34 92.00 19.73 93.30 92.00 14.36 92.91 91.00 15.84 92.72 92.00 13.57 92.37 91.00 12.95 92.61 91.00 13.13 93.12 91.00 17.95 92.69 92.00 12.56 93.44 91.00 16.12 92.57 91.00 20.94 92.89 92.00 15.85 HDL Cholesterol ( mg-dL) 46.64 45.00 11.21 47.95 47.00 11.72 47.99 46.00 11.82 47.81 47.00 10.93 47.83 47.00 10.91 47.80 47.00 11.11 48.46 47.00 11.81 47.82 47.00 11.00 48.63 48.00 11.15 48.03 47.00 10.80 47.94 47.00 11.27 Hematocrit ( %) 41.31 40.90 4.03 41.59 41.30 3.66 41.56 41.20 3.81 41.41 41.10 3.89 41.36 40.80 4.03 41.59 41.10 3.90 41.27 40.90 3.77 41.36 40.90 3.76 41.38 41.00 3.68 41.43 41.00 3.69 41.43 41.00 3.81 Immunoglobulin A, Immunoglobulin G, Hemoglobin ( g- Qn, Serum ( mg- Immunoglobulin E, Qn, Serum { mg- dL) dL) Total ( lU-mL) dL) 14.08 14.00 1.33 14.19 14.10 1.20 14.18 14.10 1.26 14.12 14.00 1.26 14.09 13.90 1.33 14.16 14.00 1.29 14.06 13.90 1.25 14.08 13.90 146.85 135.00 76.95 145.77 136.00 70.20 152.46 140.00 71.94 139.04 130.00 68.05 138.74 126.00 69.51 140.44 129.00 71.72 136.24 127.00 66.10 133.56 125.50 95.91 22.00 216.29 110.45 29.00 252.44 121.66 28.00 270.40 105.02 24.00 366.52 154.93 29.50 560.71 140.43 28.00 304.29 148.13 26.00 589.17 121.16 28.00 984.05 987.00 225.97 1009.00 992.00 224.70 1023.22 1024.00 211.05 978.64 966.00 214.49 970.77 956.50 221.08 988.82 977.50 225.14 974.63 955.00 225.79 973.48 965.00 1.24 14.08 13.90 61.91 135.67 127.00 249.54 125.82 26.00 223.89 974.31 949.00 1.22 14.13 14.00 1.21 14.12 68.70 137.82 131.00 66.13 140.40 281.14 125.05 27.00 261,12 125.92 223.71 981.68 974.00 216.57 986.23 14.00 1.25 131.00 68.99 27.00 359.11 975.00 221.78 02009 West Virginia University School of Medicine p. 17 Boys (Male, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 16 Boys (Male, <18Y0) Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Immunoglobulin M, Qn, Serum ( mgdL) 92.30 83.00 47.65 92.88 88.00 42.96 96.65 89.00 44.44 94.63 86.00 48.33 93.26 85.00 45.10 95.48 86.00 46.37 96.28 88.00 47.26 96.76 89.00 46.35 95.33 88.00 44.93 98.84 89.00 48.07 95.41 87.00 46.11 Insulin. Fasting ( ulU-mL) 20.00 12.40 31.24 21.44 13.00 34.52 19.21 11.00 26.40 19.07 11.40 36.53 17.90 10.75 24.25 20.09 11.70 36.30 17.83 10.40 24.25 18.51 12.20 23.28 18.69 10.50 31.20 17.06 11.15 20.91 18.97 11,40 29.23 Insulin-Like Growth Factor I ( ng-ml) 281.52 274.00 134.19 284.54 263.00 138.34 264.74 243.00 129.15 258.63 244.00 138.16 265.53 257.00 133.83 265.91 254.00 137.62 252.00 230.00 133.92 249.59 231.50 125.77 251.26 223.50 132.97 247.58 231.50 125.17 261.49 244.00 133.29 Iron, Serum ( ugdl) 85.98 82.00 37.97 90.04 87.00 35.19 86.92 84.00 33.31 87.16 82.00 33.44 86.30 82.50 37.18 84.90 82.00 33.79 84.36 81.00 33.25 85.61 82.00 32.68 86.54 83.00 34.76 84.39 81.00 34.31 86.21 83.00 34.46 LDH ( IU-L) 214.38 214.00 48.65 213.08 212.00 47.88 211.85 214.00 47.20 217.14 219.00 48.08 212.68 212.00 45.26 214.62 214.00 44.52 217.68 218.50 46.11 216.97 216.50 42.86 219.78 219.00 43.12 219.77 220.00 43.86 215.86 216.00 45.69 LDL Cholesterol ( Calculated) Lymphs ( %) 81.95 79.00 36.01 36.00 26.18 84.18 83.00 24.65 9.10 35.08 35.00 8.44 84.41 82.50 24.43 86.19 85.00 25.78 34.67 34.00 8.43 35.25 36.00 8.90 84.95 35.31 84.00 35.00 23.97 8.80 86.55 84.00 35.36 35.00 25.69 86.13 8.77 36.06 85.00 23.82 36.00 8.37 86.59 35.75 85.00 23.57 86.47 35.00 8.48 35.35 83.00 35.00 26.33 86.27 85.00 25.04 9.04 36.21 35.00 9.14 85.50 35.50 84.00 35.00 24.89 8.73 2009 West Virginia University School of Medicine p. 18 Boys (Male, <18Y0) Boys (Male, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 17 Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Lymphs (Absolute) ( x10e3-uL) 2.48 2.30 0.88 2.36 2.30 0.69 2.44 2.30 0.72 2.50 2.40 0.75 2.47 2.30 0.72 2.50 2.40 0.74 2.55 2.50 0.76 2.52 2.40 0.77 2.50 2.40 0.75 2.58 2.50 0.76 2.49 2.40 0.75 Magnesium. Serum ( mg-dL) MCH ( pg) 2.05 2.00 0,14 2.05 2.10 0.14 2.06 2.10 0.14 2.06 2.10 0.14 2.07 2.10 0.13 2.08 2.10 0.13 2.09 2.10 0.14 2.08 2.10 0.13 2.09 2.10 0.14 2.10 2.10 0.13 2.08 2.10 0.14 29.24 29.20 1.58 29.41 29.50 1.45 29.40 29.40 1.46 29.36 29.40 1.44 29.19 29.30 1.57 29.29 29.30 1.36 29.23 29.20 1.45 29.19 29.10 1.49 29.11 29.20 1.52 29.21 29.20 1.43 29.26 29.30 1.47 MCHC ( g-dL) MCV ( fL) 34,09 34.10 0.62 34.14 34.10 0.57 34.14 34.20 0.60 34.13 34.10 0.63 34.08 34.10 0.59 34.05 34.00 0.60 34.07 34.00 0.59 34.06 34.10 0.57 34.05 34.00 0.59 34.12 34.10 0.58 34.09 34.10 0.59 85.83 86.00 4.39 86.16 86.00 4.11 86.14 86.00 4.05 86.07 86.00 4.03 85.71 86.00 4.25 86.08 86.00 3.77 85.86 86.00 4.05 85.74 86.00 4.20 85.53 86.00 4.15 85.61 85.00 3.83 85.88 86.00 4.07 Monocytes(Absolute Monocytes ( %) ) ( x10e3-uL) 7.16 7.00 2.17 7.28 7.00 2.12 7.13 7.00 2.14 6.92 7.00 2.02 7.14 7.00 1.91 7.32 7.00 2.22 7,16 7.00 1.98 7.12 7.00 2.06 7,19 7.00 1.99 7.10 7.00 2.09 0.49 0.50 0.17 0.49 0.50 0.17 0.50 0.50 0.18 0.49 0.50 0.16 0.50 0.50 0.16 0.52 0.50 0.18 0.51 0.50 0.18 0.50 0.50 0.17 0.51 0,50 0.17 0.51 0.50 0.18 7.16 0.50 7.00 0.50 2.07 0.17 Neutrophils ( %) 53.68 54.00 9.88 54.60 55.00 9.27 55.12 58.00 9.50 54.77 55.00 9.98 54.47 55.00 9.91 54.05 54.00 9.95 53.62 54.00 9.41 53.95 54.00 9.33 54.32 54.00 9,85 53.63 54.00 10.25 54.22 54.00 9.72 2009 West Virginia University School of Medicine p. 19 Boys (Mele, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 18 Boys (Male, <18Y0) Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Neutrophils (Absolute) ( x10e3- ul) 3.83 3.50 1.59 3.84 3.60 1.49 4.10 3.70 1.78 4.06 3.80 1.57 4.01 3.70 1.62 4.04 3.70 1.74 3.93 3.70 1.48 3.92 3.70 1.42 3.99 3.70 1.49 4.04 3.70 1.76 3.98 3.70 1.60 Phosphorus, Serum ( mg-dL) 4.76 4.80 0.72 4.67 4.70 0.73 4.77 4.80 0.69 4.74 4.70 0.69 4.83 4.90 0.70 4.75 4.80 0.70 4.79 4.80 0.69 4.73 4.80 0.67 4.84 4.90 0.72 4.86 4.90 0.71 4.77 4.80 0.70 Platelets ( x10e3- Potassium, Serum uL) ( mmol-L) 316.63 4.16 305.00 4.10 78.15 0.27 306.76 4.14 302.00 4.10 74.47 0.29 308.78 4.13 303.00 4.10 67.96 0.30 312.72 4.12 307.00 4.10 73.59 0.26 303.95 4,14 293.00 4.10 71.45 0.29 311.98 4.15 302.50 4.10 81.29 0.29 305.98 4.14 300.00 4.10 68.19 0.31 310.18 4.15 302.00 4.10 73.17 0.30 318.08 4.16 310.00 4.10 72.23 0.29 314.03 4.17 305.00 4.20 72.56 0.32 310.61 4.15 303.00 4.10 73.37 0.29 Prolactin ( ng-mL) 7.22 6.50 3.78 7.06 6.30 3.71 7.33 6.50 3.85 7.43 6.40 4.42 7.44 6.50 4.46 7.36 6.40 4.27 7.41 6.40 4.19 7.42 6.60 3.59 7.39 6.40 4.25 7.15 6.40 3.53 7.32 6.50 4.00 Prostate-Specific Antigen, Serum ( ng-mL) 0.23 0.05 0.27 0.24 0.05 0.41 0.21 0.05 0.29 0.19 0.05 0.22 0.19 0.05 0.25 0.20 0.05 0.24 0.19 0.05 0.25 0.18 0.05 0.23 0.18 0.05 0.26 0.18 0.05 0.35 0.20 0.05 0.29 Protein, Total, Serum ( g-dl) 7.32 7.30 0.41 7.36 7.40 0.41 7.41 7.40 0.38 7.40 7.40 0.40 7.38 7.40 0.40 7.40 7.40 0.41 7.43 7.40 0.41 7.42 7.40 0.39 7.42 7.40 0.41 7.44 7.40 0.40 7.40 7,40 0.40 2009 West Virginia University School of Medicine p. 20 Boya (Male, <18YO) Boys (Male, <18YO) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 19 Population Decile Group -- C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Red Blood Cell RDW ( %) Count (x10e6-ul) 13.74 13.50 0.91 13.65 13.60 0.69 13.57 13.50 0.75 13.58 13.40 0.78 13.57 13.50 0.76 13.56 13.50 0.70 13.54 13.50 0.73 13.48 13.40 0.68 13.57 13.50 0.82 13.43 13.30 0.73 4.82 4.79 0.42 4.83 4.82 0.37 4.83 4.83 0.38 4.81 4.80 0.40 4.83 4.82 0.40 4.84 4.83 0.39 4,81 4.80 0.38 4.83 4.80 0.39 4.84 4.81 0.37 4.84 4.81 0.39 13.56 4.83 13.50 0.75 4.81 0.39 Sodium, Serum ( Testosterone, Thyroxine (T4) ( Triglycerides ( mg- mmol-L) T3 Uptake {% ) Serum { ng-dL) ng-dL) dL) TSH ( ulU-ml) 140.65 141.00 2.11 140.65 141.00 1.94 140.56 140.00 2.03 140.56 141.00 2.03 140.56 140,00 2.04 140.57 141.00 1.94 140.53 140.00 1.99 140.57 141.00 1.97 140.49 140.00 2.05 140.53 141.00 2.23 140.57 30.97 31.00 2.61 30.98 31.00 2.69 30.98 31.00 3.70 30.74 30,00 3.51 30.92 31.00 3.33 30.90 31.00 2.65 30.84 31.00 2.67 30.95 31.00 2.63 30.82 30.00 3.39 30.67 31.00 2.73 30.88 185.28 149.00 181.70 184.15 98.50 195.71 165.46 55.00 190.29 162.10 50.00 185.85 165.94 46.00 194.76 164.69 64.00 185.90 151.77 33.00 188.46 145.70 35.00 180.34 146.61 28.00 189.87 140.86 29.00 173.15 160.30 7.10 7.10 1.36 7.03 7.00 1.27 7.14 7.20 1.45 7.27 7.20 1.45 7.20 7.10 1.39 7.18 7.00 1.33 7.31 7.25 1.36 7.40 7.40 1.36 7.38 7.30 1.43 7.28 7.20 1.41 7.23 127.09 103.00 81.39 122.03 100.00 77.34 123.78 104.00 78.49 120.36 103.50 68.57 121.66 101.00 74.56 124.45 102.00 84.27 128.21 105.00 80.49 129.33 105.00 79.74 123.78 104.00 80.63 133.16 110.00 93.33 125.56 2.16 1.77 1.57 2.10 1.88 1.10 2.11 1.84 1.16 2.21 1.93 1.51 2.07 1.84 1.03 2.09 1.88 1.09 2.12 1.87 1.19 2.15 1.94 1.11 2.14 1.94 1.22 2.12 1.89 1.29 2.13 141.00 2.03 31.00 3.00 45.50 187.09 7.20 1.38 104.00 80.43 1.89 1.22 2009 West Virginia University School of Medicine p. 21 Boys (Male, <18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Boys (Male, <18YO) Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Uric Acid, Serum ( Vitamin B12 ( pg- mg-dl) mL) S.07 597.54 5.00 551.50 1.51 224.18 5.19 584.45 5.00 550.50 1.54 216.17 5.12 589.68 5.00 557.00 1.56 5.07 4.90 209.10 616.99 570.00 1.56 5.03 5.00 1.56 5.14 4.95 1.60 255.39 592.98 549.00 232.38 620.22 563.00 266.14 4.94 600.74 4.80 1.51 555.00 228.95 5.06 4.80 1.58 4.77 4.50 1.43 5.04 607.18 562.00 227.91 623.63 589.00 230.38 601.02 4.80 1.54 555.00 227.81 5.05 603.30 4.90 559.00 1.54 232.54 VLDL Cholesterol (Calculated) ( mg- dL) 24.31 20.00 13.98 23.62 20.00 13.64 24.03 21.00 13.62 23.60 21.00 12.37 23.59 20,00 12.99 23.60 20.00 13.05 24.77 21.00 13.73 25.03 21.00 14.24 23.80 21.00 13.04 25.21 22.00 14.04 24.18 21.00 13.51 White Blood Ceil Count ( x10e3-ul) 7.0161 6.6000 1.99185 6.9053 6.6000 1.87796 7.2665 6.9000 2.10850 7.2686 7.0000 1.93914 7.1918 7.0000 2.00470 7.2939 7.0000 2.12279 7.2042 7.0000 1.89089 7.1605 6.9000 1.84015 7.2287 7.0000 1.87373 7.3540 7.1000 2.10002 7.1909 6.9000 1.97850 Page 20 @2009 West Virginia University School of Medicine p. 22 Women (Female, >*18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 21 Women (Female, >=18Y0) Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation A-G Ratio (Final AFP Tumor Marker, Albumin, Serum ( g- Recoded Value) Serum ( ng-mL) dL) 1.50 1.50 0.24 1.51 1.50 0.23 1.51 1.50 0.22 1.51 1.50 0.23 1.51 1.50 0.23 1.51 1.50 0.22 1.51 1.50 0.23 1.52 1.50 0.22 1.51 1.50 0.22 1.53 1.50 0.23 1.51 1.50 0.23 6.78 2.00 28.83 4.60 2.00 18.40 4.77 2.00 18.78 4.62 2.00 23.12 5.58 2.00 92.43 3.77 2.00 13.65 3.81 2.00 14.72 3.33 2.00 10.11 3.21 2.00 7.40 3.06 2.00 8.12 4.52 2.00 33.76 4.31 4.30 0.34 4.35 4,40 0.30 4.37 4.40 0.30 4.36 4.40 0.29 4.38 4.40 0.29 4.38 4.40 0.30 4.38 4.40 0.29 4.38 4.40 0.29 4.38 4.40 0.28 4.41 4.40 0.27 4.37 4.40 0.30 Alkaline Phosphatase, Serum ( IU-L) Antinuclear Antibodies Direct ( U- ALT (SGPT) ( IU-L) mL) 82.54 78.00 28.89 83.29 79.00 27.79 19.96 17.00 15.51 20.29 17.00 12.84 38.71 27.00 63.51 40.23 28.00 74.62 82.71 20.75 40.49 78.00 27.34 83.65 17.00 14.53 20.84 29.00 69.15 42.37 80.00 30.01 83.28 79.00 35.10 83.22 79.00 27.09 82.64 78.00 27.87 83.62 79.00 31.39 83.27 79.00 29.93 84.38 81.00 27.39 83.21 18.00 14.01 20.71 17.00 12.61 20.83 18.00 13.70 21.18 18.00 26.94 21.56 18.00 16.37 20.74 18.00 11.85 21.94 19.00 15.18 20.80 28.00 76.19 44.55 29.00 90.46 41.60 29.00 61.58 44.09 30.00 70.51 49.92 30.00 118.30 46.08 30.00 83.39 49.01 29.00 109.70 43.24 79.00 29.34 17.00 15.77 29.00 82.09 2009 West Virginia University School of Medicine p. 23 Women (Female, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 22 Women (Female, >*s18Y0) Population Decile Group ~ C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation AST (SGOT) { IU-L) 20.34 18.00 11.30 20.62 19.00 8.75 20.94 19.00 10.10 21.16 19.00 9.89 21.39 19.00 12.35 21.46 19.00 10.17 21.74 20.00 20.09 22.25 20.00 11.77 21.66 20.00 9.14 22.28 20.00 9.58 21.29 19.00 11.66 Baso (Absolute) ( x10e3*uL) Basos(% ) 0.02 0.00 0.04 0.26 0.00 0.44 0.02 0.00 0.04 0.02 0.00 0.04 0.25 0.00 0.44 0.27 0.00 0.45 0.03 0.00 0.04 0.02 0.00 0.04 0.03 0.00 0.04 0.03 0.29 0.00 0.47 0.29 0.00 0.46 0.31 0.00 0.47 0.32 0.00 0.05 0.03 0.00 0.04 0.03 0.00 0.04 0.03 0.00 0.00 0.48 0.32 0.00 0.47 0.31 0.00 0.46 0.29 0.00 0.04 0.46 0.03 0.29 0.00 0.00 0.04 0.46 Bilirubin, Direct ( mg-dL) 0.10 0.09 0.05 0.10 0.10 0.05 0.11 0.10 0.05 0.11 0.10 0.05 0.11 0.10 0.05 0.11 0.10 0.05 0.11 0.10 0.05 0.11 0.10 0.05 0.11 0.10 0.06 0,11 0.10 0.05 0.11 0.10 0.05 Bilirubin, Total ( mg-dL) 0.35 0.30 0.21 0.37 0.30 0.21 0.38 0.30 0.22 0.38 0.30 0.23 0.38 0.30 0.21 0.38 0.30 0.21 0.38 0.30 0.21 0.39 0.30 0.22 0.38 0.30 0.21 0.38 0.30 0.20 0.38 0.30 0.21 BUN ( mg-dL) 12.78 12.00 5.57 12.90 12.00 4.88 12.97 12.00 4.87 13.35 13.00 4.99 13.34 13.00 5.03 13.61 13.00 5.17 13.94 13.00 5.72 13.91 13.00 5.39 13.86 13.00 5.02 14.12 13.00 5.33 13.41 13.00 5.23 BUN-Creatinine Ratio (Final Recoded Value) 15.69 15.00 5.07 15.80 15.00 5.04 15.79 15.00 4.82 16.04 15.50 5.00 16.06 16.00 4.94 16.23 16.00 5.01 16.44 16.00 5.08 16.45 16.00 5.11 16.36 16.00 4.98 16.45 16.00 4.95 16.09 16.00 5.01 2009 West Virginia University School of Medicine p. 24 Women (Female, >*18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Women (Female, >=18YO) Page 23 Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 1 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Calcium, Serum ( Cancer Antigen mg-dL) (CA-125) ( U-ml) CEA ( ng-mL) 9.72 16.47 1.25 9.70 12.90 0.80 0.40 9.77 9.80 0.40 9.79 9.80 17.12 27.92 12.50 750.79 14.66 12.20 4.62 1.25 0.80 3.85 1.28 0.80 0.39 10.94 2.21 9.81 14.81 1.22 9.80 12.20 0.90 0.40 19.81 2.63 9.82 15.15 1.52 9.80 12.30 0.90 0.40 21.86 11.48 9.82 14.74 1.28 9.80 12.10 0.90 0.41 14.19 1.87 9.83 14.77 1.52 9.80 12,20 0.90 0.39 11.59 8.82 9.84 14.70 1.49 9.80 12.10 0.90 0.42 11.88 5.33 9.84 14.77 1.41 9.80 12.10 1.00 0.40 14.87 1.72 9.88 14.41 1.62 9.90 11.80 1.10 0.41 14.72 3.03 9.80 16.52 1.37 9.80 12.30 0.90 0.40 255.27 5.45 Chloride, Serum ( mmol-L) 103.79 104.00 2.46 103.66 104.00 2.43 103.52 104.00 2.41 103.43 104.00 2.46 103.35 103.00 2.56 103.33 103.00 2.56 103.10 103.00 2.52 102.97 103.00 2.60 103.13 103.00 2.62 102.81 103.00 2.69 103.35 103.00 2.54 Cholesterol, Total ( mg-dL) 193.64 189.00 42.57 196,22 191.00 42.29 197.95 194.00 41.70 199.29 195.00 41.72 200.55 197.50 41.32 202.81 199.00 43.12 203.21 200.00 43.07 204.69 200.00 42.41 204.20 201.00 41,64 208.27 205.00 43.34 200.44 196.00 42.52 Cortisol ( ug-dL) 12.33 11.00 6.40 12.51 11.10 6.70 12.42 11.20 6,39 12,37 11.20 6.49 12.23 11.00 6.58 12.17 10.90 6.32 12.10 11.10 6.00 12.15 11.10 6.02 11.97 10.90 6.07 11.78 11.00 5.59 12.23 11.00 6.30 2009 West Virginia University School of Medicine p. 25 Women (Female, >= 18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Women (Female, >18Y0) Page 24 Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation C-Reactive Protein, Creatinine, Serum ( Quant ( mg-L) mg-dl) Eos ( %) 4.91 2.50 8.08 4.83 2.50 8.24 4.73 2.40 7.76 4.74 2.50 8.24 4.49 2.40 6.87 4.39 2.30 6.45 4.35 2,30 7,40 3.98 2.10 5.66 4.22 2.10 7.62 4,07 2,00 6.71 4.51 0.83 0.80 0.36 0.82 0.80 0.18 0.82 0.80 0,16 0.84 0.80 0.25 0.84 0.80 0.19 0.84 0.80 0.17 0.85 0.80 0.19 0.85 0.80 0.18 0.85 0.80 0.18 0.86 0.80 0.24 0.84 2.02 2.00 1,68 2.02 2.00 1.61 2.02 2.00 1.52 2.04 2.00 1.63 2.04 2.00 1.60 2.13 2.00 1.65 2.11 2.00 1.69 2.09 2.00 1.54 2.20 2.00 1.78 2.13 2.00 1.59 2.07 2.30 7.43 0.80 2.00 0.22 1.63 Eos (Absolute) ( x10e3-uL) 0.16 0.10 0.13 0.15 0.10 0.12 0.15 0.10 0.11 0.15 0.10 0.13 0.15 0.10 0.12 0.16 0.10 0,14 0.16 0.10 0.13 0.15 0.10 0.11 0.16 0.10 0.13 0.16 0.10 0.12 0.16 0.10 0.13 Folates (Folic Acid), Estradiol ( pg-mL) Serum ( ng-mL) 441.04 43.50 2311.97 262.21 36.00 1720.56 264.31 34.00 1563.34 206.20 31.00 1310.70 176.27 31.00 1318.58 143.16 29.00 1053.12 148.35 27.00 1023.75 139.30 26.00 1162.83 100.37 26.00 649.82 84.43 24.00 648.83 212.99 31.00 1448.15 17.52 14.50 10.31 17.76 14.70 10.32 17.55 14.70 10.25 17.85 14.60 10.56 18.30 14.95 10.61 18.44 15.30 10.48 18.73 15.50 10.66 19.26 16.00 10.77 19.93 16.35 10.82 20.52 17.20 10.91 18.46 15,20 10.59 2009 West Virginia University School of Medicine p. 26 Women (Female, >*18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 25 Women (Female, >=18Y0) Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Free Testosterone, Direct ( pg-mL) 0.76 0.60 1.40 0.75 0.60 0.88 0.79 0.60 0.84 0.72 0.60 0.65 0.78 0.60 1.02 0.77 0.60 1.70 0.72 0.60 0.69 0.73 0.60 0.78 0.67 0.50 0.72 0.67 0.50 0.77 0.74 0.60 1.02 Free Thyroxine Index (Final Recoded Value) GGT ( IU-L) 2.36 2.30 0.50 2.40 2.40 0.51 2.38 2.40 0.49 2.39 2.40 0.53 2.40 2.40 0.50 2.40 2.40 0.46 2.39 2.40 0.48 2.44 2.40 0.50 2.43 2.40 0.51 2.41 2.40 0.50 2.40 2.40 0.50 23.10 16.00 31.33 24.83 17.00 35.29 24.21 17.00 29.61 24.87 17.00 32.64 24.53 17.00 27.33 24.21 17.00 25.57 25.58 17.00 39.51 25.52 17.00 31.51 25.61 17.00 40.96 26.73 18.00 36.28 24.79 17.00 33.14 Globulin, Total ( g<JL) 2.92 2.90 0.38 2.94 2.90 0.37 2.94 2.90 0.36 2.94 2.90 0.37 2.95 2.90 0.36 2.94 2.90 0.35 2.94 2.90 0.36 2.92 2.90 0.36 2.95 2.90 0.36 2.93 2.90 0.37 2.94 2.90 0.37 Glucose, Serum ( mg-dL) 101.61 93.00 38.97 101.03 93.00 37.79 101.46 93.00 35.19 101.32 93.00 35.91 100.13 93.00 30.69 101.30 93.00 35.48 101.39 94.00 32.15 100.12 94.00 28.87 100.82 94.00 29.65 102.33 95.00 31.17 101.16 93.00 34.21 HDL Cholesterol { mg-dL) 53.20 51.00 14.31 54.00 52.00 14.32 54.44 53.00 14.53 54.36 53.00 14,35 54.61 53.00 14.58 55.40 54.00 14.66 55.48 54.00 14.76 55.98 54.00 15.07 56.19 54,00 14.61 56.31 54.00 15.27 54.85 53.00 14.64 02009 West Virginia University School of Medicine p. 27 Women (Female. >*1BY0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Women (Female, >=18Y0) Page 26 Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Hematocrit ( %) 39.94 40.10 3.67 40.54 40.70 3.25 40.73 40.80 3.19 40.78 40.80 3.26 40.82 40.90 3.30 40.91 41.00 3.33 40.86 40.90 3.26 41.01 41.00 3.31 41.01 41.00 3.25 41.02 41.10 3.36 40.71 40.80 3.35 Hemoglobin { g-dL) 13.42 13.60 1.29 13.65 13.70 1.10 13.72 13.80 1.08 13.73 13.80 1.11 13.73 13.80 1.13 13.76 13.80 1.11 13.74 13.80 1.11 13.78 13.80 1.12 13.79 13.80 1.09 13.81 13.80 1.15 13.70 13.70 1.14 Immunoglobulin A, Qn, Serum ( mg*dl) 217.05 202.00 98.89 217.52 203.00 98.13 216.30 200.00 98.79 215.28 200.00 98.02 215.42 199.00 99.09 211.45 195.00 99.30 212.06 197.00 101.84 208.14 192.00 105.55 214.50 196.00 112.15 211.54 195.00 111.69 214.25 198.00 101.96 Immunoglobulin E, Total ( lU-mL) 68.54 16.00 246.80 67.31 15.00 231.32 55.28 15.00 145.39 62.23 14.00 228.02 63.11 14.00 250.67 64.69 14.00 281.07 67.28 15.00 261.61 56.56 14.00 157.75 50.42 13.00 184.56 62.67 13.00 233.88 62.25 14.00 226.84 Immunoglobulin G, Qn, Serum { mg-dL) 1062.24 1043.00 285.75 1068.15 1047.00 248.02 1063.10 1043.00 248.19 1059.83 1039.00 253.38 1055.02 1028.00 251.13 1042.23 1020.00 235.82 1037.47 1016.00 248.61 1029.35 997.00 258.12 1037.79 1015.00 246.25 1025.85 1002.00 255.99 1049.95 1028.00 252.21 Immunoglobulin M, Qn, Serum ( mg-dL) 140.28 123.00 156.28 137.43 122.00 86.07 135.67 121.00 80.90 133.95 117.00 86.86 134.24 118.00 83.64 136.06 119.00 92.69 130.35 114.00 84.55 133.73 114.00 89.46 132.48 116.00 93.00 133.83 113.00 128.28 135.16 118.00 103.35 2009 West Virginia University School of Medicine p. 28 Women (Female, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Women (Female, >=18Y0) Page 27 Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Insulin, Fasting ( ulU-mL) 19.97 11.80 26.83 20,70 11.90 30.48 20.35 12.20 28.31 20.09 12.30 23.80 19.84 11.50 31.20 20.18 11.20 32.06 18.76 11.70 23.23 18.51 11.20 26.12 18.19 11.10 24.11 17.35 10.30 20.96 19.51 11.60 27.14 Insulin-Like Growth Iron, Serum { ug- Factor I ( ng-ml) dL) LDH { IU-L) 164.08 151.00 74.79 157.56 142.00 73.63 155.79 142.00 70.73 149.95 136.00 70.70 149.67 135.00 72.47 146.29 133.00 69.67 141.00 128.00 65.11 138.67 125.00 66.36 136.55 123.00 63.51 130.97 119.00 58.56 75.30 71,00 35.29 79.62 75.00 34.20 80.24 76,00 34.07 80.12 76.00 33.38 80.79 77.00 33.60 81.03 76.00 33.59 82.45 79.00 33.64 83.61 79.00 34.47 81.82 78.00 32.68 81.39 78.00 31.02 167.32 162.00 35.30 169.05 165.00 40.60 168.46 164.00 33.98 169.54 165.00 33.41 170.96 166.00 50,83 172.48 168.00 35.67 172.80 168.00 33.36 173.96 169.00 34.57 173.62 170.00 44.94 177.47 174.00 36.41 148.55 135.00 70.07 80.32 76.00 33.82 171.13 167.00 38.31 LDL Cholesterol ( Calculated) Lymphs ( %) 109.40 106.00 34.88 110.74 108.00 33.49 111.92 109.00 34.16 112.63 109.00 35.08 113.86 110.00 34.81 114.77 111.0C 35.82 114.18 111.00 34.44 115,87 112.00 36.24 114.58 111.00 34.59 117.12 113.00 36.15 113.16 110.00 34.98 28.97 29.00 7,64 29.23 29.00 7.68 29.46 29.00 7.57 29.54 29.00 7.35 29.46 29.00 7.69 29.48 29.00 7.29 29.53 29,00 7.64 29.81 29.00 7.41 29.65 30.00 7.51 29.68 29,00 7.60 29.45 29.00 7.55 2009 West Virginia University School or Medicine p. 29 Women (Female, >*18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Women (Female, >=18YO) Page 28 Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Lymphs (Absolute) ( x10e3-uL) 2.13 2.10 0.85 2.13 2.00 0.73 2.16 2.10 1.81 2.14 2.10 0.66 2.15 2.00 0.93 2.13 2.00 0.68 2.14 2.10 0.74 2.12 2.00 0.73 2.10 2.00 0.68 2.18 2.00 1.75 2.14 2.00 1.03 Magnesium, Serum ( mg-dL) MCH ( pg) MCHC ( g-dL) M C V(fL) 1.98 2.00 0.17 1.99 2.00 0.17 1.99 2.00 0.16 2.00 2.00 0.17 2.00 2.00 0.17 2.01 2.00 0.17 2.01 2.00 0.17 2.02 2.00 0.17 2.02 2.00 0.16 2.02 2.00 0.16 2.00 2.00 0.17 30.18 30.50 2.31 30.43 30.60 1.95 30.50 30.60 1.78 30.52 30.60 1.81 30.52 30.60 1.93 30.60 30.70 1.79 30.71 30.80 1.77 30.76 30.90 1.84 30.69 30.80 1.82 30.80 30.90 1.88 30.54 30.70 1.93 33.60 33.70 0.77 33.67 33.70 0.68 33.69 33.70 0.64 33.68 33.70 0.64 33.63 33.70 0.67 33.64 33.70 0.63 33.64 33.70 0.65 33.60 33.60 0.64 33.61 33.60 0.64 33.65 33.70 0.65 33.64 33.70 0.67 89.79 90.00 5.89 90.37 91.00 5.08 90.55 91.00 4.66 90.64 91.00 4.73 90.76 91.00 5.02 91.01 91.00 4.75 91.33 91.00 4.67 91.58 92.00 4.89 91.34 91.50 4.83 91.53 92.00 4.94 90.80 91.00 5.04 Monocytes(Absolute) Monocytes ( %) ( x10e3-uL) 5.68 6.00 1.97 5.75 6.00 2.00 5.85 6.00 2.01 5.83 6.00 1.92 5.83 6.00 2.03 5.94 6.00 2.00 6.01 6.00 2.09 6.02 6.00 2.05 5.99 6.00 2.03 5.96 6.00 1.99 5.87 6.00 2.01 0.42 0.40 0.16 0.42 0.40 0.16 0.42 0.40 0.16 0.42 0.40 0.16 0.42 0.40 0.16 0.43 0.40 0.16 0.43 0.40 0.17 0.43 0.40 0.17 0.42 0.40 0.16 0.43 0.40 0.17 0.42 0.40 0.16 @2009 West Virginia University School of Medicine p. 30 Women (Female, > 18YO) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 29 Women (Female, >-18YO) Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std, Deviation Mean Median Std. Deviation Mean Median Std, Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Neutrophils ( %) Neutrophils (Absolute) ( x10e3- UL) 63.06 63.00 4.84 4.60 8.66 62.74 63.00 1.85 4.78 4.40 8.77 62.40 63.00 8.61 62.30 62.00 1.89 4.73 4.40 1.80 4.71 4.40 8.34 62.38 63.00 1.76 4.72 4.40 8.72 62.13 62.00 8.22 62.03 1.81 4.66 4.40 1.75 4.66 62.00 8.69 61.75 62.00 8.44 4.40 1.75 4.55 4.30 1.68 61.85 4.55 62.00 8.52 61.94 62.00 4.30 1.65 4.61 4.30 8.45 1.71 62.32 63.00 4,70 4.40 8.56 1.78 Phosphorus, Serum ( mg-dL) 3.64 3.60 0.59 3.62 3.60 0.58 3.64 3.60 0.56 3.65 3.60 0.58 3.65 3.60 0.55 3.65 3.70 0.54 3.67 3.70 0.55 3.68 3.70 0.53 3.69 3.70 0.53 3.73 3.70 0.56 3.66 3.70 0.56 Platelets ( x10e3uL) 299.33 290.00 73.95 294.88 290.00 69.57 293.45 288.00 67.09 295.88 290.00 68.82 293.54 287.00 68.15 295.01 290.00 70.80 292.02 288.00 67.85 291.10 285.00 67.61 292.26 285.00 72.75 291.70 285.00 68.70 294.25 288.00 69.77 Potassium, Serum ( mmol-L) 4.08 4.10 0.32 4.07 4.10 0.32 4.08 4.10 0.34 4.09 4.10 0.34 4.10 4.10 0.33 4.12 4.10 0.34 4.11 4.10 0.34 4.13 4.10 0.36 4.14 4.10 0.36 4.16 4.10 0.37 4.10 4.10 0.34 Prolactin ( ng-mL) 14.35 8.10 27.10 11.99 8.00 19.65 12.12 7.80 21.30 11,94 7.80 22.40 10.80 7.80 16.28 10.94 7.80 17.10 10.61 7.60 15.76 10.46 7.60 15.37 9.83 7.50 12.22 9.53 7.30 17.70 11.47 7.80 19.57 2009 West Virginia University School of Medicine p. 31 Women (Female, >~18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Women (Female, >=18Y0) Page 30 Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Protein, Total, Red Blood Cell Serum ( g-dl) RDW ( %) Count ( x10e6-uL) 7.24 7.20 0.46 7.29 7.30 0.43 7.31 7.30 0.43 7.31 7.30 0.43 7.32 7.30 0.43 7.32 7.30 0.43 7.32 7.30 0.43 7.31 7.30 0.43 7.32 7.30 0.42 7.33 7.30 0.42 7.30 7.30 0.43 14.24 13.90 1.56 13.96 13.70 1.33 13.89 13.60 1.21 13.87 13.70 1.19 13.92 13.70 1.24 13.87 13.70 1.12 13.88 13.60 1.17 13.90 13.70 1.22 13.86 13.70 1.18 13.87 13.60 1.23 13.94 13.70 1.28 4.46 4.47 0.40 4.50 4.50 0.37 4.51 4.51 0.36 4.51 4.52 0.37 4.51 4.52 0.37 4.51 4.51 0.39 4.48 4.49 0.38 4.49 4.50 0.38 4.50 4.51 0.38 4.49 4.49 0,38 4.49 4.50 0.38 Sodium, Serum ( mmol-L) 140.39 140.00 2.18 140.48 141.00 2.17 140.53 141.00 2.13 140.60 141.00 2.19 140.58 141.00 2.28 140.66 141.00 2.28 140.54 141.00 2.19 140.57 141.00 2.36 140.69 141.00 2.34 140.62 141.00 2.35 140.55 141.00 2.24 T3 Uptake ( %) 29.23 30.00 4.09 29.07 30.00 3.89 29.03 29.00 3.85 29.00 30.00 3.82 29.17 29.00 3.65 29.26 30.00 3.66 29.21 30.00 3.64 29.36 30.00 3.61 29.36 30.00 3.49 29.41 30.00 3.39 29.20 30.00 3.75 Testosterone, Serum ( ng-dL) 41.11 38.00 22.55 40.49 37.00 28.12 40.88 38.00 23.16 39.11 37.00 18.47 39.90 37.00 25.00 39.05 37.00 21.68 38.08 36.00 19.39 38.03 36.00 19.28 37.33 35.00 20.44 37.03 35.00 20.81 39.30 36.00 22.33 Thyroxine (T4) ( ngdL) 8.21 8.00 1.91 8.37 8.10 1.94 8.31 8.10 1.90 8.36 8.10 1.96 8.34 8.10 1.91 8.33 8.10 1.85 8.30 8.10 1.86 8.41 8.20 1.89 8.38 8.20 1.87 8.28 8.10 1.87 8.32 8.10 1.90 (02009 West Virginia University School of Medicine p. 32 Women (Female, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 31 Women (Female, ^ ISYO ) Population Decile Group - C8 (PFOA) 1 2 3 4 5 6 7 8 9 10 Total Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Triglycerides ( mgdL) TSH ( ulU-mL) 159.25 128.00 143.77 162.28 128.00 146.00 159.94 132.00 114.51 164.97 137.00 112.77 164.65 135.50 111.83 165.57 137.00 113.78 173.12 140.00 143.28 169.82 140.00 113.23 171.08 143.00 113.90 178.18 150.00 119.37 166.12 136.00 125.58 2.23 1.65 4.66 2.19 1.68 3.42 2.35 1.72 3.67 2.32 1.71 3.52 2.42 1.74 5.69 2.35 1.76 4.29 2.51 1.77 5.03 2.25 1.78 2.81 2.43 1.79 4.26 2.51 1.84 3.76 2.34 1.73 4.20 Uric Acid, Serum ( Vitamin B12 ( pg- mg-dL) mL) 4.68 4.50 1.34 4.80 4.60 1.30 4.82 4.70 1.29 4.88 4.70 1.33 4.91 4.70 1.36 4.95 4.80 1.36 4.99 4.80 1.48 4.98 4.80 1.42 4,98 4.80 1.46 5.08 4.90 1.42 4.89 4.70 1.38 473.85 417.00 269.27 473.11 415.00 281.99 458.83 406.00 241.98 470.83 410.00 284.50 476.46 415.00 270.03 478.50 414.00 287.22 476.79 415.00 282.93 492.85 422.00 310.31 494.51 428.00 285.19 507.04 434.00 305.39 479.02 417.00 281.16 VLDL Cholesterol (Calculated) ( mg- dL) 28.95 25.00 15.60 28.80 25.00 15.28 29.27 26.00 15.10 30.13 27.00 15.67 30.18 26.00 15.56 30.40 27.00 15.79 30.90 27.00 15,55 30.92 27.00 15.77 31.27 28.00 15.60 32.17 29.00 15.98 30.15 27.00 15.60 White Blood Cell Count ( x10e3-uL) 7.55 7.20 2.27 7.49 7.10 2.26 7.47 7.20 2.70 7.44 7.10 2.13 7.46 7.20 2.26 7.39 7.00 2.17 7,41 7.10 2.17 7.27 6.90 2.10 7.25 7.00 2.03 7.39 7.00 2.74 7.42 7.10 2.30 2009 West Virginia University School of Medicine p. 33 Men (Male, >*18Y0) Men (Male, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 32 Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation A-G Ratio (Final Recoded Value) 1.59 1.60 0.27 1.61 1.60 0.24 1.62 1.60 0.24 1.63 1.60 0.24 1.62 1.60 0.24 1.62 1.60 0.24 1.62 1.60 0.24 1.61 1,60 0.24 1.61 1.60 0.23 1.62 1.60 0.24 1.62 1.60 0.24 AFP Tumor Marker, Serum ( ng-mL) Albumin, Serum ( g-dL) 2.45 2.00 1.01 2.50 4.40 4.40 0.34 4.49 2.00 1.06 2.55 2.00 4.50 0.29 4.51 4.50 2.20 0.29 2.56 4.53 2.00 4.50 1.29 12.47 0.29 4.54 2.00 4.50 524.43 2.64 0.28 4.53 2.00 4.50 1.43 0.29 2.57 2.00 1.26 2.58 2.00 1.25 2.60 4.53 4.50 0.29 4.52 4.50 0.29 4.53 2.00 4.50 1.28 2.61 0.27 4.53 2.00 1.06 4.50 0.27 3.60 4.52 2.00 4.50 169.61 0.29 Alkaline Phosphatase, Serum ( IU-L) ALT (SGPT) ( IUL) 86.70 82.00 28.46 25.00 32.12 86.54 17.99 31.37 83,00 26.00 31.09 36.36 85.22 30.46 82.00 26.14 26.00 21.08 84.78 32.18 82.00 25.79 26.00 34.52 85.28 82.00 31.69 26.00 23.82 20.68 84.08 31.24 80.00 26.00 31.75 26.21 84.02 31.08 81.00 26.00 25.89 20.23 83.56 30.73 81.00 26.00 23.80 19.29 83.38 30.55 80.00 26.00 26.02 84.04 18.49 31.64 81.00 27.00 24.02 19.67 84.58 31.04 81.00 26.00 26.81 23.92 Antinuclear Antibodies AST (SGOT) ( Direct ( U-mL) IU-L) 38.02 26.00 24.41 22.00 47.67 37.96 11.64 25.98 27.00 22.00 56.61 26.23 37.30 27.00 56.66 37.01 27.00 52.36 38.13 28.00 24.83 22.00 12.40 25.65 23.00 16.57 25.32 23.00 62.32 40.19 11.29 25,77 28.00 23.00 77.25 40,43 18.61 25.61 30.00 59.23 42.44 30.00 23.00 15.69 25.36 23.00 73.78 39.85 14.03 25.37 29.00 51.89 41.48 29.00 23.00 11.15 25.65 23.00 58.48 39.47 28.00 11.54 25.42 23.00 60.89 15.19 Baso (Absolute) ( x10e3-uL) 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.02 0.00 0.04 0.03 0.00 0.04 0.03 0.00 0.04 0.03 0.00 0.05 0.03 0.00 0.05 0.03 0.00 0.05 0.03 0.00 0.04 2009 West Virginia University School of Medicine p. 34 Men (Male, >-18Y0) Men (Male, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 33 Population Oecile Group - C8 (PFOA) "I Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Total Median Std. Deviation Mean Median Std. Deviation Bilirubin, Direct ( Basos(% ) mg-dl) 0.26 0.00 0.44 0.25 0.00 0.44 0.26 0.00 0.44 0.28 0.00 0.45 0.27 0.00 0.45 0.30 0.00 0.46 0.30 0.00 0.47 0.33 0.00 0.48 0.33 0.00 0.47 0.32 0.00 0.47 0.29 0.00 0.46 0.13 0.11 0.07 0.13 0.12 0.09 0.13 0.12 0.06 0.14 0.12 0.25 0.13 0.12 0.06 0.14 0.12 0.15 0.13 0.12 0.06 0,13 0.12 0.06 0.13 0.12 0.06 0.13 0.12 0.06 0.13 0.12 0.11 Bilirubin, Total ( mg-dL) BUN ( mg-dL) 0.47 0.40 0.32 0.50 0.40 0.29 0.50 0.40 0.29 0,52 0.40 0.46 0.51 0.40 0.29 0.51 16.20 15.00 7.34 15.33 14.00 5.46 14.97 14.00 5.10 14.99 14.00 4.65 15.15 15.00 4.88 15.45 0.40 0.35 0.52 0.40 0.29 0.52 0.40 0.30 0.51 0.40 0.28 0.51 0.40 0.29 0.51 0.40 15.00 5.13 15.28 15.00 5.18 15.30 15.00 4.80 15.40 15.00 4.59 15.58 15.00 4.83 15.34 15.00 0.32 5.13 BUN-Creatinine Ratio (Final Recoded Value) 14.81 14.00 4.42 14.75 14.00 4.32 14.44 14.00 4.14 14.42 14.00 4.11 14.52 14.00 3.93 14.72 14.00 4.14 14.52 14.00 3.93 14.58 14.00 4.03 14.71 14.00 3.90 14.75 14.00 4.06 14.62 14.00 4.08 Calcium, Serum ( Cancer Antigen mg-dL) (CA-125) ( U-mL) 9.79 9.80 0.41 9.85 13.33 10.60 12.64 12.41 9.80 0.39 9.87 9.90 0.37 9.89 9.90 0.38 9.89 9.90 0.37 9.87 10.70 8.66 12.64 10.70 8.70 13.88 10.70 73.28 13.21 11.00 22.52 13.05 9.90 0.38 9.88 9.90 0.39 9.88 9.90 0.38 9.88 10.80 15.51 13.18 10.70 20.14 13.00 10.90 13.39 12.64 9.90 0.38 9.89 9.90 0.38 9.87 10.90 10.13 12.92 11.00 8.55 13.03 9.90 10.80 0.38 27.20 CEA ( ng-ml) 1.67 1.30 1 69 1.53 1.30 1 24 1.51 1.20 1 24 3.15 1.30 62 47 1.49 1.20 1 25 1.82 1.20 14 59 1.73 1.30 9 33 1.53 1.20 1 52 1.63 1.30 1 92 1.55 1.30 1 18 1.77 1.30 20.89 2009 West Virginia University School of Medicine p. 35 Men (Mele, >*18YO) Men (Male, >=s18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 34 Population Decile Group 1 2 3 4 5 6 7 8 S 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Chloride, Serum Cholesterol, ( mmol-L) Total ( mg-dL) Cortisol ( ug-dL) C-Reactive Protein, Quant ( Creatinine, Serum Eos (Absolute) ( Estradiol ( pg- mg-L) ( mg-dL) Eos ( %) x10e3-uL) m l) 103.13 188.39 13.02 4.30 1.14 2.50 0.19 25.56 103.00 185.00 12.30 1.80 1.00 2.00 0.20 24.00 2.77 44.02 5.33 8.26 0.77 1.81 0.15 13.15 103.05 189.19 13.31 4.08 1.05 2.42 0.18 24.75 103.00 2.45 187.00 41.13 12.70 5.45 1.70 10.94 1.00 0.36 2.00 1.80 0.10 24.00 0.14 9.44 103.13 191.66 13.32 3.39 1.05 2.45 0.18 24.82 103.00 188.00 12.90 1.60 1.00 2.00 0.10 24.00 2.36 43.47 5.50 7.17 0.24 1.86 0.15 9.58 103.05 192.90 13.42 3.25 1.05 2.41 0.18 25.20 103.00 2.37 103.07 191.00 42.00 195.14 12.70 5.61 13.50 1.50 8.12 3.19 1.00 0.24 1.05 2.00 1.76 2.38 0.10 0.14 0.18 24.00 9.71 25.14 103.00 191.00 12.90 1.50 1.00 2.00 0.10 24.00 2.42 44.09 5.59 7.11 0.19 1.69 0.13 9.41 102.98 192,45 13.24 3.16 1.06 2.41 0.18 25.23 103.00 188.00 12.70 1.40 1.00 2.00 0.10 24.00 2.48 43.16 5.54 7.72 0.21 1.73 0.13 9.62 102.88 195.74 13.11 2.99 1.06 2.36 0.17 29.04 103.00 2.54 102,75 103.00 193.00 44.01 194.47 191.00 12.50 5.55 13.04 12.50 1.40 6.82 2.98 1.40 1.00 0.21 1.06 1.00 2.00 1.69 2.48 2.00 0.10 0.12 0.18 0,10 24.00 203.00 24.93 24.00 2.43 41.37 5.51 6.41 0.21 1.86 0.15 9.36 102.83 196.88 12.74 2.84 1.08 2.44 0.18 25.39 103.00 194.00 12.20 1.40 1.00 2.00 0.10 24.00 2.48 40.88 5.38 5.79 0.18 1.80 0.14 9.94 102.72 199.15 12.76 2.81 1.07 2.49 0.18 25.89 103.00 197.00 12.10 1.30 1.00 2.00 0.10 25.00 2.45 41.34 5.46 6.41 0.20 1.73 0.13 9.29 102.94 194.12 13.13 3.22 1.06 2.43 0.18 25.64 103.00 191.00 12.50 1.50 1.00 2.00 0.10 24.00 2.47 42.59 5.50 7.41 0.29 1.77 0.14 66.97 2009 West Virginia University School of Medicine p. 36 Men (Male, >*18Y0) Men (Male, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 35 Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Folates (Folic Acid), Serum ( ng-mL) Free Testosterone, Direct ( pg-mL) Free Thyroxine Index (Final Globulin, Total ( g- Glucose, Serum ( Recoded Value) GGT ( IU-L) dL) mg-dL) 17.82 14.60 10.66 17.13 13.70 10.12 16.62 13.80 9.66 16.91 14.30 9.80 17.14 14.40 9.89 17.28 14.15 10.08 17.22 14.40 9.66 17.35 14.20 10.06 18.10 15.10 10.22 18.31 15.20 10.10 17.41 14.40 10.02 9.68 9.00 4.82 9.94 9.30 4.11 10.16 9.60 4.55 10.42 9.80 4.85 10.31 9.90 4.03 10.44 9.80 4.76 10.35 9.80 4.53 10.40 9.90 4.43 10.19 9.70 4.26 10.11 9.60 4,06 10.23 9.70 4.44 2.37 2.30 0.47 2.42 2.40 0.48 2.41 2.40 0.45 2.42 2.40 0.48 2.41 2.40 0.46 2.40 2.40 0.50 2.41 2.40 0.48 2.42 2.40 0.44 2.42 2.40 0.44 2.40 2.40 0.49 2.41 2.40 0.47 39.99 27.00 54.56 40.63 27.00 82.21 36.84 26.00 45,57 36.85 26.00 47.34 37.72 27.00 41.93 39.01 26.00 80.87 37.42 26.00 49.47 37.60 26.00 50.72 35.58 27.00 36.79 37.42 28.00 36.06 37.70 27.00 53.34 2.83 2.80 0.42 2.83 2.80 0.36 2.84 2.80 0.36 2.83 2.80 0.36 2.85 2.80 0.36 2.85 2.80 0.38 2.85 2.80 0.36 2.86 2.80 0.35 2.85 2.80 0.35 2.84 2.80 0.36 2.84 2.80 0.37 117.95 100.00 56.00 111.76 99.00 47.73 107.28 98.00 37.98 106.10 97.00 34.28 106.25 97.00 38.14 106.50 97.00 37.81 107.68 98.00 38.96 106.99 97.00 37.74 106,83 98.00 37.26 106.33 97.00 35.93 107.80 98.00 39.63 HDL Cholesterol ( mg-dL) 43.36 42.00 11.60 43.75 42.00 11.65 43.71 42.00 11.37 43.69 42.00 11.67 43.89 42.00 11.09 43.98 42.00 11.99 43.94 42.00 11.65 43.71 42.00 11.29 44.53 43.00 11,84 44.57 43.00 11.89 43.96 42.00 11.62 Hematocrit ( %) 44.81 45.30 4.04 45.46 45.70 3.37 45.56 45.80 3.33 45.71 45.90 3.32 45.79 45.90 3.36 45.53 45.80 3.43 45.78 45.90 3.36 45.76 45.80 3.24 45.69 45.80 3.22 45.61 45.70 3.29 45.61 45.80 3.38 @2009 West Virginia University School of Medicine p. 37 Men (Male, >= 18Y0) Men (Male, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 36 Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Immunoglobulin A, Immunoglobulin G, Hemoglobin ( g- Qn, Serum ( mg- Immunoglobulin E, Qn, Serum ( mg- d l) dL) Total ( lU-mL) dL) 15.15 237.76 115.25 1031.10 15.30 1.40 15.40 218.50 122.04 236.86 31.00 305.31 124.30 1000.50 288.67 1045.34 15.50 1.16 15.44 216.00 115.60 234.06 29.00 379.58 122.34 1025.00 242.18 1052.60 15.50 217.00 30.00 1032.00 1.15 105.95 390.73 237.76 15.50 230.69 98.26 1042.90 15.60 1.13 15.51 15.60 1.14 15.44 215.00 108.89 230.56 214.00 105.94 227.05 28.00 266.30 108.88 29.00 308.85 101.34 1019.00 236.73 1042.40 1022.00 239.54 1046.13 15.50 1.17 211.00 106.64 28.00 270.33 1029.00 271.93 15.50 229.14 106.00 1037.83 15.60 1.14 212.00 109.04 26.00 323.16 1014.00 239.94 15.48 15.50 1.11 15.47 15.50 1.10 228.09 213.00 109.47 226.16 210.00 119.77 102.86 29.00 254.38 99.62 27.00 316.21 1035.99 1012.00 239.91 1034.26 1007.00 249.87 15.46 224.98 93.22 1028.10 15.50 1.12 208.50 103.67 28.00 238.53 1007.00 241.11 15.45 229.82 105.82 1039.42 15.50 213.00 28.00 1017.00 1.16 110.30 304.74 247.71 Immunoglobulin M, Qn, Serum ( mg-dL) Insulin-Like Insulin, Fasting ( Growth Factor I ( ulU-ml) ng-mL) 99.86 86.00 72.63 103.17 26.37 13.70 40.05 24.51 150.68 141.00 61.09 154.58 88.00 76.32 105.26 13.40 34.18 23.67 144.00 62.31 156.37 92.00 68.15 102.04 90.00 66.89 104.57 88.00 77.07 101.76 88.00 76.36 105.88 90.00 87.14 105.09 90.00 83.94 104.91 89.00 82.82 102.49 87.00 88.22 13.60 33.72 23.34 12.95 33.04 21.67 12.30 29.84 22.23 12.60 28.74 22.80 12.90 32.77 22.87 12.60 33.18 21.37 12.10 30.30 20.33 11.80 25.78 147.00 62.43 153.43 146.00 58.00 154.33 144.00 60.44 150.74 142.00 58.46 150.95 139.00 62.98 145.76 135.00 60.16 143.57 135.00 56.05 144.21 135.00 56.45 103.67 89.00 22.64 12.70 150.03 140.00 78.98 31,82 59.79 2009 West Virginia University School of Medicine p. 38 % t Men (Male, >` 18Y0) Men (Male, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 37 Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Iron, Serum ( ug-dL) LDH ( IU-L) 89.57 85.00 34.74 93.70 89.00 34.92 92.89 89.00 33.42 94.53 89.00 35.11 95.13 91.00 34.23 93.78 89.00 34.09 95.18 91.00 33.39 94.63 90.00 33.11 94.17 90.00 33.41 95.55 90.00 34.35 94.15 90.00 34.05 171.24 167.00 34.15 172.01 167,00 40.88 169.82 166.00 32.47 171.14 168.00 33.57 170.71 167.00 31.94 171.08 167.00 40.37 171.69 167.00 37.46 171.00 167.00 33.19 171.39 168.00 30.88 17242 169.00 30.49 171.27 167.00 34.45 LDL Cholesterol ( Calculated) 104.20 101.00 35.01 107.44 104.50 34.31 108.70 107.00 34.90 110.44 108.00 35.74 111.68 109.00 36.36 109.04 107.00 35.25 111.61 109.00 35.42 111.46 109.00 35.33 112.53 111.00 34.65 114.25 112.00 34.70 110.61 108.00 35.27 Lymphs ( %) 27.97 28.00 7.91 28.68 29.00 7.42 28.73 28.00 7.34 29.02 29.00 7.37 28.76 28.00 7.49 28.53 28.00 7.31 29.00 29.00 7.60 28.54 28.00 7.44 28.79 29.00 7.49 28.64 29.00 7.31 28.70 28.00 7.45 Lymphs (Absolute) ( x10e3-uL) 2.07 2.00 0.74 2.05 2.00 0.66 2.09 2.00 0.68 2.06 2.00 0.72 2.07 2.00 0.87 2.01 1.90 0.64 2.09 2.00 2.48 2.04 1.90 0.98 2.05 1.90 1.23 2.01 1.90 0.63 2.05 2.00 1.13 Magnesium, Serum ( mg-dL) MCH ( pg) MCHC ( g-dL) MCV { ft.) 2.02 2.00 0.16 2.03 2.00 0.16 2.03 2.00 0.15 2.04 30.89 31.00 1.93 30.98 31.00 1.60 30,87 30.80 1.55 30.88 33.79 33.80 0.68 33.89 33.90 0.62 33.88 33.90 0.60 33.90 91.42 92.00 5.15 91.48 91.00 4,42 91.14 91.00 4.22 91.14 2.00 0.15 2.04 2.00 0.15 2.04 2.00 0.15 2.04 30.90 1.57 30.93 30.90 1.53 30.97 31.00 1.56 31.01 33.90 0.62 33.87 33.90 0.61 33.91 33.90 0.61 33.87 91.00 4.26 91.37 91.00 4.20 91.37 91.00 4.27 91.62 2.00 0.15 2.05 2.00 31.00 1.52 31.00 31.00 33.90 0.59 33.83 33.80 91.00 4.21 91.68 91.00 0.15 1.51 0.59 4.19 2.05 2.10 31.01 31.00 33.86 33.90 91.62 91.00 0.15 2.05 1.59 31.07 0.61 33.90 4.35 91.71 2.10 31.00 0.15 1.55 2.04 30.97 33.90 0.59 33.87 92.00 4.30 91.47 2.00 31.00 33.90 91.00 0.15 1.58 0.61 4.33 2009 West Virginia University School of Medicine p. 39 + Men (Male, >*18Y0) Men (Male, >=18Y0) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 36 Population Decile Group - C8 (PFOA) 1 Mean Median Std. Deviation 2 Mean Median Std. Deviation 3 Mean Median Std. Deviation 4 Mean Median Std. Deviation 5 Mean Median Std. Deviation 6 Mean Median Std. Deviation 7 Mean Median Std. Deviation 8 Mean Median Std. Deviation 9 Mean Median Std. Deviation 10 Mean Median Std. Deviation Total Mean Median Std. Deviation Monocytes(Absolu Monocytes ( %) te) ( x10e3-uL) 6.69 7.00 2.18 6.77 7.00 2.05 6.78 7.00 2.21 6.80 7.00 2.13 6.74 7.00 2.15 6.83 7.00 2.18 6.88 7.00 2.11 6.84 7.00 2.13 6.92 7.00 2.08 6.92 7.00 2.11 6.83 0.49 0.50 0.19 0.48 0.50 0.17 0.49 0.50 0.18 0.48 0.50 0.18 0.48 0.50 0.18 0.48 0.50 0.18 0.49 0.50 0.17 0.48 0.50 0.18 0.49 0.50 0.18 0.49 0.50 0.28 0.49 7.00 2.14 0.50 0.19 Neutrophils ( %) 62,59 63.00 8.98 61.88 62.00 8.26 61.78 62.00 8.42 61.49 62.00 8.33 61.85 82.00 8.39 61.93 62.00 8.34 61.45 62.00 8,53 61.80 62.00 8.40 61.52 62.00 8.47 61.63 62.00 8.38 61.75 62.00 8.44 Neutrophils (Absolute) ( x10e3-uL) 4.81 4.50 1.78 4.60 4.30 1.75 4.65 4.30 1.72 4.53 4.20 1.68 4.61 4.30 1.93 4.54 4.20 1.69 4.49 4.20 1.62 4.52 4.20 1.62 4.47 4.20 1.66 4.51 4.20 1.94 4.56 4.30 1.74 Phosphorus, Serum ( mg-dl) 3.53 3.50 0.69 3.50 3.50 0.62 3.50 3,50 0.60 3.49 3.50 0.59 3.49 3.50 0.59 3.52 3.50 0.61 3.52 3.50 0.60 3.50 3.50 0.57 3.53 3.50 0.57 3.55 3.50 0.56 3.51 3.50 0.60 Platelets ( Potassium, x10e3-ul_) Serum ( mmol-L) 269.06 261.00 71.48 259.31 253.00 58.97 262.71 260.00 61.03 261.90 258.00 61.08 261.54 256.00 59.36 258.40 253.00 60.62 257.49 254.00 57.01 258.35 254.00 63.53 257.83 4.23 4.20 0.38 4.19 4.20 0.35 4.19 4.20 0.31 4.19 4.20 0.33 4.21 4.20 0.32 4.21 4.20 0.35 4.22 4.20 0.35 4.24 4.20 0.33 4.24 253.00 59.20 258.31 253.00 58.42 260.05 255.00 60.78 4.20 0.34 4.26 4.20 0.34 4.22 4.20 0.34 Prolactin ( ngmL) 7.78 6.70 5.70 9.09 6.90 60.63 8.08 7.00 15.63 8.41 6.90 31.87 7.62 6.80 3.96 7.80 7.00 4.25 9.17 6.90 59.21 8.52 7.00 43.85 10.06 6.90 98,23 8.44 6.80 26.47 8.53 6.90 47.03 2009 West Virginia University School of Medicine p. 40 Men (Male, >=18YO) Men (Male, >=18YO) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PF0A Deciles, Stratified by Age Gender Page 39 Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Prostate-Specific Antigen, Serum ( Protein, Total, ng-ml) Serum ( g-dL) Red Blood Cell Sodium, Serum ( RDW { %) Count ( x10e6-ul) mmol-L) T3 Uptake (% ) Testosterone, Serum ( ng-dl) Thyroxine (T4) ( ng-dL) 1.03 0.70 1.46 1.00 0.60 1.95 0.91 0.60 1.10 1.04 0.60 5.10 1.04 0.70 2.32 1.02 0.60 2.21 1.31 0.60 20.59 1.06 0,70 2.16 1.07 0.70 1.82 1.16 0.70 2.21 1.07 0.70 7.15 7.24 7.20 0.49 7.32 7.30 0.42 7.36 7.30 0.42 7.36 7.40 0.41 7.38 7.40 0.42 7.37 7.40 0.43 7.38 7.40 0.42 7.38 7.40 0.42 7.38 7.40 0.41 7.37 7.40 0.41 7.36 7.40 0.42 14.10 13.80 1.32 13.81 13.70 0.96 13.75 13.60 0.96 13.72 13.60 0.96 13.70 13.60 0.94 13.73 13.60 1.05 13.68 13.60 0.96 13.67 13.50 0.86 13.70 13.60 0.93 13.67 13.50 0.96 13.73 13.60 0.98 4.92 4.97 0.49 4.98 5.01 0.42 5.01 5.03 0.41 5.03 5.04 0.41 5.02 5.05 0.42 4.99 5.03 0.43 5.01 5.03 0.42 5.00 5.01 0.40 5.00 5.02 0.40 4.99 4,99 0.41 5.00 5.02 0.42 140,62 141.00 2.41 140.77 141.00 2.18 140.91 141,00 2.15 140.97 141.00 2.12 140.92 141.00 2.24 140.88 141.00 2.24 140.93 141.00 2.28 140.81 141.00 2.22 140.88 141.00 2.32 140.83 141.00 2.28 140.86 141.00 2.24 32.17 32.00 3.00 32.13 32.00 3.00 32.07 32.00 3.01 32.04 32.00 3.09 32.08 32.00 3.03 32.15 32.00 3.09 32.13 32.00 3.01 32.09 32.00 2.94 31.90 32.00 2.94 31.96 32.00 2.98 32.06 32.00 3.01 368.81 350.00 164.51 370.68 348.50 161.00 369.03 350.00 152.36 374.51 351.00 161.57 367.07 351.00 146.26 379.58 354.00 194.50 368.96 345.00 153.02 373.01 355.00 156.51 371.30 352.00 145.68 380.90 362.00 152.22 372.75 353.00 158.83 7.41 7.40 1.52 7.58 7.50 1.53 7.56 7.50 1.46 7.59 7.50 1.56 7.56 7.55 1.49 7.52 7.50 1.51 7.54 7.50 1.51 7.58 7.60 1.44 7.63 7.60 1.59 7.55 7.50 1.49 7.56 7.50 1.51 2009 West Virginia University School of Medicine p. 41 Men (Male, >*18YQ) Tabular (Numeric) Summary for Clinical Lab Values within Population C8/PFOA Deciles, Stratified by Age Gender Page 40 Men (Male, >18Y0) Population Decile Group 1 2 3 4 5 6 7 8 9 10 Total C8 (PFOA) Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Mean Median Std. Deviation Triglycerides ( mg-dl) ------T O ----- Cholesterol Uric Acid, Serum ( Vitamin B12 ( (Calculated) ( TSH ( ulU-mL) mg-dl) pg-mL) mg-dL) White Blood Cell Count ( x10e3-uL) 227.79 169.00 204,97 204.45 163.00 157.54 210.52 163.00 2.24 1,72 4.60 2.17 1.66 4.07 2.01 1.69 6.17 6.10 1.42 6.18 6.10 1.36 6.32 6.20 498.27 435.00 293.16 475.49 432.00 244.98 469.84 429.00 34.27 31.00 16.86 34.08 31.00 16.96 33.69 30.00 7.5773 7.3000 2.14875 7.3220 7.0000 2.12782 7.4239 7.1000 184,32 211.81 171.00 159.38 214.90 170.00 193.97 213.40 167.00 183.14 218.79 1.43 2.14 1.70 2.61 2.18 1.71 3.58 2.21 1.73 3.08 2.31 1.36 6.37 6.30 1.37 6.40 6.30 1.37 6.31 6.20 1.36 6.37 224.40 468.99 424.00 214.36 473.37 431.00 221.26 480.26 431.00 255.18 467.49 16.91 34.65 32.00 17.26 34.70 32,00 16.84 34.32 31.00 17.05 35.41 2.12238 7.2665 6.9000 2.08487 7.3487 7.0000 2.34641 7.2174 6.9000 2.05305 7.2451 173.00 189.84 214.44 1.72 5.09 2.17 6.30 1.35 6.39 428.00 201.36 476.98 32.00 17,14 35.54 6.9000 3.13498 7.2307 175.00 158.74 1.74 2.46 6.30 1.38 430.00 242.89 33.00 16.95 6.9000 2.15060 216.17 2.13 6.36 484.29 35.62 7.1924 176.00 169,82 222.71 179.00 174.93 215.50 171.00 177.49 1.75 2.05 2.23 1.78 2.90 2.18 1.73 3.27 6.30 1.33 6.41 6.30 1.33 6.34 6.30 1.36 434.00 258.18 480.92 437.00 232.96 476.98 431.00 237.83 33.00 17.14 35.95 33.00 16.97 34.92 32.00 17.03 6.9000 2.33300 7.2096 6.9000 2.38990 7.2863 6.9000 2.32800 (>2009 West Virginia University School of Medicine