Document ZnXezBrmRMBjpDERezmRZmeZd

ESTABU& NlDiaO? 1 E. I. d u P o n t d e N e m o u r s & C o m p a n y incorporated W il m in g t o n , D e l a w a r e 19898 POLYMER PRODUCTS DEPARTMENT EXPERIMENTAL STATION PERSONAL AND CONFIDENTIAL cc: A. J. Dahl B. W. Karrh L. J. Papa Pral File I.C. - 353 - N11400 - 269 ^4ZZ(p- 15%I May 21, 1981 DR. K. C. HOBBS F&F AJAX, ONTARIO ANALYSIS OF BLOOD SAMPLES FOR PERFLUOROOCTANOATE (Job No. 811-662; PRAL Nos. 81-1966-1970; Notebook Nos. E22514.E26238) As requested in your letter of 5/5/81 to L. J. Papa, the five blood samples submitted then have been analyzed for perfluorooctanoate (Cg). Results and sample identification are given in the attached table. As noted there, the analyses were done using a gas chromatographic method specific for Cg (Lab Method Number ES-567) but results have been reported as ppm F for comparison with total organic fluorine analyses. Precision is + 10% relative standard deviation over most of the concentration range, somewhat less at the lowest values. The lower limit for quantitation is 0.007 ppm F (0.01 ppm perfluorooctanoic acid), with a detection limit of 'L 0.004 ppm which can be distinguished from the reagent background but not well quantitated. Please contact me (772-4440) or L. J. Papa (772-2745) if you have any questions regarding the analyses. General questions on blood sampling can be directed to J. V. Raines or L. F. Percival. Attachment jah Key Words: Perfluorooctanoic Acid Perfluorooctanoate Blood Analysis GC S. S. Stafford There's a world of things we re doing som ething abouf 000087 EXP000024 EID713838 TABLE I CONCENTRATION OF PERFLUOROOCTANOATE IN BLOOD (a) Sample______________ _____________ PRAL N o . Date Sampled P.R.No. 81-1966 5/5/81 81-1967 81-1968 5/5/81 81-1969 5/5/81 81-1970 5/6/81 Name GC Analysis_ Date Analyzed 5/13/81 5/13/81 5/14/81 5/14/81 5/14/81 [Cr ], Pg F/g bl n.d. 0.048 n.d. n.d. n.d. (a) Analysis as described in Lab Method ES-567 ("Determination of Perfluorooctanoic Acid in Blood, Gas Chroinatographic Method", S. Stafford, 4/3/81), using the packed column GC analysis with perfluoro-n-octanoic acid as calibration standard. (b) Although the analysis is specifically for perfluorooctanoate (acid or salts), concentrations are given in ppm fluorine for comparison with the results of total organic fluorine analyses. (ppm F = 0.688 x ppm perfluorooctanoic acid) Estimated uncertainty is + 10% relative standard deviation. The lower limit for quantitation is 0.007 ygF/g. The detection limit is ^ 0.004 ygF/g, but concentrations in that range cannot be well quantitated and are reported as < 0.007. None detected (n.d.) is reported for samples with [Cg] < 0.004 ppm. which cannot be distinguished from reagent background. REDACTED* EXPOOO02 5 EID713839 000088