Document ZnLr6Qw4ND3Mnvo21Nz10NkkO

March 5,2007 Via Electronic and U.S. Mail Richard Irons, PhD, DABT Principal Investigator, Shanghai Health Study University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Ralph J Altiere, PhD Dean, School of Pharmacy University of Colorado Health Sciences Center 4200 East 9th Avenue, C238 Denver, CO 80262 Re: The Shanghai Health Study Dear Drs. Irons and Altiere: We are writing on behalf of the the scientific and clinical research being We appreciate Dr. Shanghai and We (API) in support of '-HH"HE:,uU~ Health Study. unique project in of this worthy effort. of the Benzene Health Research study (contingent upon API lm1[10nal tenns of the study being ~~~'''~~,.u~ Quality Assurance/Quality progress and payment. Please see attached and API have considered Dr Irons draft Budget for Extension and JCML Transition funding up to $6,559,864 has been provisionally for the following (as described in the referenced Plan A Study ~VJ.HLH"''' Total (Tables I and 2) $5,759,864 Plan B Laboratory Transition Personnel Proposed Budget (From Table 3) $400,000 Post Study Costs for continued publication of study findings $400,000 TOTAL $6.559.864 Formal authorization and disbursement of these additional monies are contingent upon successful execution of an agreement between API and the research entity that will be continuing the study. API Exhibits A-I to A-III, Proposal Guide For Prospective SH ELL-MCCLU RG-065093 Contractors are attached; the information requested therein is necessary for the establishment of the new commitment. Given the urgency to execute a grant/contract to continue the study, API looks forward to receiving a proposal in the near future to extend the existing grant or to establish a new contract with the University of Colorado, CinPathoGen, Inc. or another entity. Once again we appreciate the continuing efforts of Dr Irons and the University of Colorado support this unique project. We look forward to the successful completion of this work. Sincerely, Red Cavaney Cc: C. Klaus D. Ross D. Wilkerson SH ELL-MCCLU RG-065094