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* 2pf 3M DDLiaerAsryeLrR.PJAoDh,nsDonABT CSo5r1pSoerdaaTtoDxecplapramyent 2PO0BCooxne3,22B0ing 0220-02.6.02 Supa MN 5813332200 AR 226-1068 SSomIoHsTiIsmaRmOeeam +s = roms ECHR- 0202-00373 soto OB Document Processing Center (7407M) EOfPfAiceEaosft P--olRloutoimon 6P4r2e8veAntttin:onSaencdtiToonx8i(ccs) US EPA W1a2s0h0iPnegntnosny,lvDaCnia20A4v6e0,-0N00W1 C @ i. ws CB Contain, *+ ntain NC CEYTIFIED MAIL TNeSeCthAyl8(pEe)rfSluUoProPoLctEaMneEsNulTfAonLamIiNdoFeOthRaMnAolTI(OCNASORNN: 1691-99-2); Docket Ref -0373 Dear Sir: 3onMNiesetshuyblmiptetrifnlgutohreoofcitnaalnersepuolrftonfarmoimdoCeotvhaannocle L(aCbAoSrRaNto1r6io9e1ns-9t9h-e2)2,-yoeriagrinraallfyeenodtiinfgiesdtutdyo} EdaPtAediMnaayle2tt4e,r2d0a0t1e.d DIencaedmdibteiron,4,t2w0o00r,epwoirtlhs oadndsiteirounmalainndfotirsmsauteioannaplryosivsidferdominsaamleptlteers~~J% +51} collected during the study are enclosed. 5 iE Sdipertaagtu0e,-D1,a3w,le30y,ra1t0s0w&er3e0g0ivpepnmNefeotrhuypl tpoer1f0l4uwoeroeokcst.anAesruelcfoovnearmyidgoroeutphaantol10(098p.1pm%)waisnthe=> 73* 3 dSaocsreidfifcoers o5c2cwuererkesd,ataf4t,cr14whaincdh,$3unwtereeaktsedfofrehediswtaopsatghiovleongyu,ntmilettaebromilniatteioqnu.antiItnatteiroinm, and cell 3 Tprhorloifuegrhattioenr.m,Tshuerv3i0va0l-pwparsm ugnraofufpesctweedrbeytetrrmeaitnmaetnetd,aafntedrbsoedvyewnewiegehtkssowferterelaotwmeenrt.in the 100 ppm dose in 30-ppm group. males. Liver effects occurred at Hepatotoxicity was not 100 ppm, present in w1i0t0h-tphpemexrceecpotvieornyoafnicmyasltisc. degeneration In males, thheypraotiodceflollulliacrulaardecenlolmaadweansomiancwraesasiendcirneatsheed1a0t0t-hepp1m00anpdptmhedo1s0e.0-Fpoprm-freemcaolvese,ry groups. For further information on this study contact Dr. John Butenhoff, 651-733-1962. Sincerely, ; LDiarmccytoRr., ACorJpolrarteoTorxicology 2f A >) > Enclosures & epa-oTs 0008118400 I Reports Submitted with Letter of February 8, 2002: a. FEitnhayll RPeeprofrltu,or1o0o4c-taWneecskulDfioentaamriydCoarEctihnaongoelniinciRtaytsS,t(uCdoyvwaintcheNSatrurdoyw6R32a9n-g2e12()9,8.1%) N- December 13, 2001. b. APnFaOlSy,ticPaFlOLSaAb,orPaFtoOrSyARAep,orEtX,FDOeStEe-rmOiHn,atMi5on5o6fatnhdePPrFeOsSenEcAe ainndSeCronucmenatnrdatLiiovnerof SEtahmapnloel,so3fMCrEln:vCirDo(nSmDe)ntIaGlSLBaRborRaattosryExRpeopsoerdt tNoo.N-ETtOhXy-l0P0e1r,flLuaobrooroacttoarnycsRuelqfuoensatmiNdoo. U2103, 3M Refernce No. T-6316.1, June 6, 2001. c. PAnFaOlSy,ticPaFlOLSaAb,orPatFoOrSyARAep,orEt(,FDOeStEe-rOmiHn,atMi5on6o,ftahned PPrFeOseSnEceAainndSCeornucmenatnrdatLiiovneorf SEtahmapnloels, o3fMCrElnv:iCrDo(nSmDe)ntIaGlSLBabRorRaattosrEyxRpeopsoerdt tNoo.N-TEOthXy-l00P3e,rlLuaobrooroacttoarnyesRuelqfuoensatmiNdoo. U2104, 3M Reference No. T-6316.1, June 6, 2001 L