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WORLD HEALTH ORGANIZATION . -<1- ORGANISATION MQNDIALE DE LA SANTE I trtjfM - CENTRE INTERNATIONAL DE RECHERCHE SUR LE CANCER foJ Wwviwx Lts- INTERNATIONAL AGENCY FOR RESEARCH ON CANCER <2rv*Jdi& d vwiunhM^w^OUIS AL8E8T-T HOMAS - 69 372, LYON C*dix2~ FRANCE ' TI.(7)I7$II,I1~ TtUgr. Uniconctr Lyon -- Tlx 33880023 -- W/UnJsiuJhxJuctX<n> j<\ In taplv plaaia rafar to C2/12/12 Prtara da rappaiar la (4f4ranea : 22 February 1982 Dear Dr Harris, Thank you for your prompt reply to my request to review the section on Industrial Processes for the Rubber Monograph. The comments were very helpful and have been passed on to Mrs Heseltine for incorporation into the section. For your information, I have enclosed the Summary Table from our meeting in February; please refer to Supplement 1 of the Monographs for an explanation of the terms used in the table, although please note that the text and definitions in Supplement 3 (in which this table will be included) were somewhat modified by the February Working Group. Thank you again for your extensive contribution to the monographs programme. With best regards. URL 05109 Yours sincerely Lynne Haroun Retrieval and Coordination of Carcinogenicity Data Division ofEnvironmental Carcinogenesis Dr W.D. Harris Industrial Toxicologist Uniroyal, Inc. World Headquarters Middlebury CT 06749 USA PS: As in Supplement 1, a descriptive evaluation for each chemical or industry will appear in Supplement 3; that for the Rubber Industry will be based on the summary table prepared by the June Working Group. -1- Surmary evaluations of carcinogenic risk to himans from chemicals, industries and industrial processes* based on evidence for carcinogenicity in hunans and in anime! & arid for activity in short-term tests1 Chemical, process or industry Evidence for carcinogenicity in hijnans Evidence forlcarcinogenicity in:animals Evidenc J A . -- Summary for ac :iv 'ity;: evaluation in short-term'of carcino- tests "genic risk to-humans J Acrylonitrile limbed sufficient:: -sufficient Actinomycin D inadequate: :l;imited sufficient .Adriamycin inadequate;::sufficient. sufficient Aflatoxins :: 1 iiai ted ; j: sufficient1:: sufficient Aldrin inadequate limited inadequate Anitrole "inadequate sufficient inadequate AnaestHatijCs volatile;- V Aniline : inadequate . inadequate inadequate inadequate limited inadequate Auramine (technical-h. .;;;::iimited grade) limited sufficient Manufacture Auramine sufficient Azathioprine sufficient limited limited 3CNU inadequate sufficient sufficient 2A 2B 2B 2A 3 2B 3 3 2R 1 1 2B URL 05110 a In IARC Monographs 1-29, for vtaich data in hinans were available ^ This table does not include known human carcinogens such as tobacco smoke, betel quid and alcohol beverages since they have not yet been considered in the IA.RC Monographs I URL 05111 2- - Chemical, process or industry Evidence for carci nogenicity in hirnans Evidence for carci nogenicity in animals Evidence Summary for activity evaluation in short-term of carcino tests genic risk to-humans Benzyl chloride inadequate limited sufficient1 3 Benzoyl chloride inadequate inadequate inadequate...... : 3 Benzal chloride inadequate limited:;. limited Ben2otrichloride Beryllium and beryl lion compounds inadequate sufficient-; ^Limited limited: -;suficieht: inadequate 2B 2A Bleomycin inadequate: :: inadequate sufficient 3 Boot and shoe manufacturesufficien t .. and repair (certain:::. occupations) : :: -1 Cadmiut and:adjriiat compounds Carbon tetrachloride:::;::. :: :limited:::.. sufficient inadequate inadequate1 sufficient inadequate 2B 23 Carpenters arid::::- joiners (certain--- exposures) :::::::: 3 CCN'J ::::::L: inadequate sufficient sufficient 23 Certain combined chemotherapy for lymphomas (including MOP?) sufficient 1 Chlorambucil sufficient sufficient sufficient 1 Chloramphenicol limited inadequate inadequate 2B a In IARC ^onogr^phs 1-29, for which data in humans were available I -3- Chemical, process or industry Evidence for cardnogenicity in humans Evidence for carci nogenicity in animals Evidence Summary for.: activity evaluation in^short-term of carcino : testis-- genic risk to' `humans Cnlordane/Heptachlor inadequate 1 .mited' inadequate--- 3 Chloroform inadequate sufficient inadequate Chloroprene Cisplatin inadequate inadequate: sufficient inadequate - limited :;auff icient U&*J . 2B Clofibrate Clcniphene inade.qr.u. a. .te':: limited instfequate inadequate -inadequate no data 3 3 Cyclamates Cyclophosphamide inadequate sufficient sufficient sufficient 3 1 2,4-D and esters;::.. :: inadequate. inadequate (see al?b::phenoxy:acetic; acid ^Sters) inadequate 3 Dacarbazine";;::- inadequate sufficient limited 23 Dapsone ::: inadequate 1 imi ted inadequate 3 DDT inadequate sufficient inadequate 23 Benzidine based dyes ::: Direct {Slack 38 (technical grade) Direct Blue 5 (technical grade) Direct Brown 95 (technical grade) inadequate sufficient inadequate inadequate sufficient no data inadequate limited no data 2B 23 2B srdLy % r" ro a In IARC Monographs 1-29, for which data in hinans were available ft c .0 ^ 0 .-4- Chemical, process or industry Evidence for carci nogenicity in hanans Evidence for carci nogenicity in animals Evidence Summary for activity evaluation in short-term of carcino tests' ;tb:hunans genic risk o r tho-Dichioroben zene pa ra-Dichlorobenzene inadequate inadequate inadequate::. 3 3,3'-Dichlorobenzidine Dichloromethane inadequate sufficient limited inadequate inadequate: inadequate 2&. <Lo ow. fHU 3` Dieldrin inadequate': limited'::::: .'inadequate 3 Diethyl sulphate limited:::. :Suff:icient "sufficient Z*. 3,3'-Qimethoxybenzidine . (ortho-Dianisidine).:: inadequate:: .sufficient 1imited 23 Dimethylcarbamoyl: chloride inadequate : sufficient sufficient 23 Dimethyl suipKaie... sufficient sufficient 2\ 1,4-DiOXarie' '-inadeauate: sufficient inadequate 23 EDichlorohydtfin inadequate sufficient sufficient 2B Ethylene dibfarn&fB- ::: inadequate sufficient sufficient 2B Ethylene oxide ....... limited sufficient 23 UK Uj4JL Ethylene thiourea inadequate sufficient limited 23 5-Fluorouracil inadequate inadequate limited 3 /Formaldehyde (gas) inadequate sufficient sufficient 23 In IARC Monoaroahs 1-29, for which data in hunans were available I -5- Chemical, process or industry Evidence for carci nogenicity in humans Evidence for carci nogenicity in animals Evidence Summary for activity evaluation in short-term of carcino- tests::' genic risk tb:hiinans Furniture manufacture sufficient - -1. 1 Underground haematite mining with radon Haematite sufficient t inadequate inadequate: inadequate ;;:i. 3 : Hexachlorocyclohexane Hydralazine inadequate: .limited inadequate': : 1 irarted inadequate sufficient 3 3 /Hydrazine inadequate ; Sufficient. sufficient 2B Iron dextran complex::::::--- 'ii-ijiadequate: sufficient;: ;:inad equate 3 Isonicotinic acid hydrazide inadequate limited 1imited 3 Manufacture -cif: -is^popyi `: :::suff icieftt: alcohol;: ^'strong-acid: process):::::::. -1 Isopropyl -'oils - inadequate inadequate no data 3 Lead and lead compounds Leather goods manufacture inadequate sufficient (for some salts) inadequate - 3 3 Leather tanning inadequate - -3 Lumber and sawnill industry inadequate - -3 a In IARC Monographs 1-29, for v*>ich data in humans were available URL 05114 a URL 05115 -s- Chemical,process or industry Evidence Evidence for carci- for carcinogenicity nogenicity in humans in animals Evidence Summary for activity evaluation in shbrt-term of carcino- tests' genic risk -tollmans Manufacture of magenta limited 2A Magenta (technical grade) inadequate inadequate inadequate:':;:`;;3. 6-Mercaptopurine inadequate inadequate'! .^sufficient 3':' Methotrexate inadequate' :; i nadequate ! !suf f ic i en t 3 Methoxsalen with UVA therapy (P5JVA) sufficient ;jSufficient :sufficient 1 Metronidazole j inadequate!!: isuf f ic lent f: -inadequate 23 Myleran :isgfficient::ilintited sufficient 1 1-Maphthylamine *: .inadequate inadequate sufficient 3 Nickel andiceffcaj-n:::. nickel; oKtpounds: and/or nickel' refining ! sufficient -sufficient inadequate 1 Nitrogen mustard. and 'its'::!, inadequate sufficient sufficient hydrochlor ide" ::!!:. 2A Oestrogens and pfrpgestiris:::: Combined oral ::i!: contraceptives '* Sequential oral contraceptives limited limited inadequate 2A 23 a in IARC Monographs 1-29, for which data in humans were available tk Sufficient for liver adenomas I -7- Chemical, process or industry Evidence for carcinogenicity in hunans Evidence for carcinogenicity in animals Evidence Summary for activity evaluation in short-term of carcino- tests'"' genic risk tbiihiihans Other oestrogen- progestin combinations inadequate 3 ::::::: Conjugated oestrogens Dienoestrol Ethinyloestradiol Mestranol sufficient inadequate. inadequate i - limited:::::: .inadequate: inadequate inadequate': sufficient 'inadequate inadeqayte': : sufficient. inadequate 23 2B 23 17-beta Oestradicii inadequate: sufficient: inadequate 23 Gilormadinone:acetate inadequate limited no data Dime th iS tefcone :inadequate inadequate no data 3 3 Ethyrpdiol::dia*etate : : inadequate- limited no data 17-aLphi: Hvd roicy-H::::. inadequate inadequate no data progesterone caprbate Lynoestrerwl::::. ::: inadequate inadequate no data 3 3 3 Medroxyprogesterone::: inadequate limited acetate ::::: inadequate Norethisterone inadequate sufficient no data 3 23 Norethynodrel inadequate limited no data 3 Norgestrel inadequate inadequate no data 3 Progesterone inadequate sufficient no data 28 tholone limited no data no data 2A chlorophenol inadequate inadequate inadequate 3 vso'M f' cr> a In IM3C Monograms 1-29, for which data in hurians were available URL 05117 . -ft- Chemical,process or industry Evidence for cardnogenicity in humans Evidence Evidence Summary for card- for activity evaluation nogenicity in s!hbrt-term of carcino- in animals tests" genic risk :to:hhnans Analgesic mixtures containing phenacetin sufficient limited::: inadequate- Phanacetin Phena zopyridine limitet d sufficient limited inadequate sufficient: -no data Phenelzine inadequate limited'::::: inadequate Phenobarbital and its sodium salt inadequate" i limited inadequate Phenyl butazone :ho data::::: -inadequate M-Phenyl-2-naphthylamine :ihft3equate * inadequate * inadequate Phenytoin and its sodiun:: .limited salt limited inadequate Polychlorinated ' bijtftenyls :::_i;nadequate: :Sufficient inadequate Predni sons inadequate inadequate inadequate Procarbazine i:.inadequate sufficient sufficient sufficient no data Pulp and paper manufacture (certain " exposures) Reserpine Rubber industry (certain occupations) Saccharin Spi ronolactone inadequate inadequate limited sufficient - inadequate limited inadequate limited inadequate --. inadequate no data 1 2B 3 3 3 3 2B 23 3 2A 25 3 3 1 3 3 a in iARC 'kjncnraphs 1-2?, for which data in hunans were available URL 05118 -9- Chemical, process or industry Evidence for carci nogenicity in hunans Evidence for carci nogenicity in animals Evidence Surma ry for activity evaluation in short-term of carcino- tess;::' genic risk to humans / Styrene inadequate limited:::: sufficient::. 3 Styrene oxide inadequate 1 imited sufficient ::3. Sulfafurazole inadequate inadequate : inadequate Sulfamethoxazole inadequate limited 'inadequate / Phenoxy acetic acid herbicides (occupational exposures to) limited:::::: ' Chlorophenols (occupa^;::;:: "limited ':::: "i :j;;.. 'J::: 3 2B 23 y J/ 2,4,5-T and esters*:::::::::. Tetrachlorodibenao-parar::: dioxin inadequate inadequate inadequate sufficient inadequate Te trachlocoe fcftvl ene ihadequa te' limited inadequate ortho-Tbluidiine:and its:::: inadequate sufficient sufficient hyd rochlor ide Treosulphan / Trichloroethylene / 2,4,5-Trichlorophenol no data inadequate inadequate limited inadequate inadequate inadequate no data 2,4,f5-Tr ichlorophenol inadequate sufficient no data Tris(aziridinyl)-paca- benzoquinone (Triaziquinone) inadequate limited sufficient Tris(l-aziridinyl)phosphine sulphide (Thiotepa) inadequate sufficient sufficient 3 2B 3 2A 1 3 3 23 2B 23 a In IA3C Monographs 1-29, for which data in hunans were available I Chemical, process or industry Uracil mustard Vinblastine Vincristine Vinylidene chloride .-10- Evidence for carci nogenicity in hunans Evidence Evidence Summary for carci- for activity evaluation nogenicity in shoict-tem) of carcino- in animals testsgenic risk :tb:hixnans inadequate sufficient sufficient"2 - 2B inadequate inadequate inadequate :f:3! inadequate inadequate inadequate 3'-" inadequate" limited2::: :l:imi ted 3 URL 05119 in jftRG Monographs 1-29* for which data in hunans were available I 11.- - Chemical, process or industry Evidence for carci nogenicity in hiroans Evidence for carci nogenicity in animals Evidence Surmary for activity evaluation in short-term of carcino tests genic risk toiftunans 4-Aminobiphenyl Arsenic and arsenic compounds Asbestos Benzene Benzidine M/N-BisU-chloroethyl)- sufficient sufficient sufficient-- 1 sufficient inadequate limited h. sufficient sufficient;; -inadequate sufficient: :.limited 1-imi ted sufficient' -sufficient 'suifESfcient . sufficient : 1 imited::: . 1 imifted 1 1 1 1 Si s (ch1oromethy1 tifer:. :siifff icient ::SUf:f i'cient" limited and technical grade:::::::. chloromethyl methyl* if:::::::. ether "i::::::::::::;::::ff Cn ro.m i uri: shd ` certain:::. ch romi Larri: icbmpo unds :;::. sufficient:: ^sufficient sufficient Diethylstilboestrol sufficient inadequate Melphalan sufficient sufficient sufficient Mustard gas ::::::::: : sufficient limited sufficient 2-Naphthylamine sufficient sufficient sufficient Soots, tars and mineral oils sufficient sufficient sufficient Benzo () pyrene inadequate sufficient sufficient Vinyl chloride sufficient sufficient sufficient 1 1 1 1 1 1 1 2A 1 a in iARC Monographs 1-29, for which data in ha-nans were available URL 05120