Document ZR7J2N7LBeK4GD5qvboby3X8

I; - . ; : i.i 1 t; i a , it .ip i.. j r . ' in i nth " I I;'11* ! ' t'11 ;; i i I i; i i. i' i , i I <: <111 r i I'll r < I > til tl--1, I oplll-'U t Ilf r.im -p. Op.v : |.*i io.- '! I i. : i : till' i in' V-' .IS |-i t l-u-li'lHV lovurd rM"..tb j p f 11 - i. . |f. o :> f . wt can speak of extent if* epithelial d,'Si|u imnt ion .... i i .literal i on of the shapes of epithelial cejls, format i on of numerous '..pho-cs and p.ion' foreign body cells, os well as proliferation of lh" .'.rfivt tissue. Tiiureupun. as mentioned by l.inzbach, the various r ' ones ore released from their normal, condition w i t lion t the injury to lie : iasae ht inj; i r o 11 e, i v e ''iiungh foe the cell to collapse. Th i s in, : ; r a. d f.".kI'. ace loom'd regene r al. i on and tin; disorder of normal tissue '.opd i t i oas con probably ho considered os promoting factors in the develop ment of cancer. These theories also apply to pleural growth- The pleura is involved in the decomposition process. Here we. find epithelial clesquamat ion, fibrin deposits, regeneration of the. connective tissue, torn i f i cat Ion and accumu lation of asbestos crystals and asbestos particles (Gloyne, et al.). All these theories ace based on statistical figures and constitute valid arguments in support of the inner correlation between asbestosis and lung cancer. tn addition to the increased incidence of cancer in ashestesis nati ons, vo also require proof of the reproducibility of the conditions chcough anim.-.l experimentation. As yet, this point could not be proven in the case of asbestpsis. This, however, is not based on negative results of ertperir.'.v.tts performed, but rather simply due to the fact that this question has not as vet been addressed to any significant degree. The first experiments vv-rc performed by l.'ocdmann and Sorge, who obtained nstoundinply similar results. These were .already mentioned in the previous paragraphs. For more certainty, however, it will be necessary to obtain forthet confirma tion and recognition of \hls complex correlation from other specialists. nevertheless, all the observations made up to now tend to indicate with all probability that Nordmann's theory on occupational cancer in asbestos workers is a valid one. Other authors such as Cloync, Lynch and Smith, Egbert- and Geiger, as well as Linzbach, also tend to take a correla tion of the cause into consideration. No attempt has yet been made from any side to deny this assumption. If we now attempt to determine the origin of the carcinogenic effect or - hector particles, we must differentiate between general and local promat i np, factors. We can generally assume that the occurrence of cancer in usually due to an inclination (predisposition) toward this d i sense. .lout win re we .ulinulil look for the answer for Cilia is difficult to ray. Wc. know (mm I'.o'ierti I hum.ui experimental pathology that pred ispiisit Lou toward cancer in dependent upon systemic factors. This is particularly evident by the 1 net tliar under identical experimental conditions and fairly similar ex po-urn to carcinogenic hazards, only a number of the endangered persons dv ..ciuallv suffer from cancer. The available asbcstnsis-re.latcd ohsc.rvatio:'. inateri.iV is not sufficient to allow us to perform an analysis of familiu: carcinogenic conditions. -17-