Document ZJvdKrexa0rbj7y291gbJrgwd

General Offices Mr. K. G. bitssinger * General Offices Regina Brenclck-3RC Dr. R. FU Hatfcon-1700 0 Mr. R. D. MinteerMJO Mr. T. P. 3ands-GQ Mr. W, A. Wilkinson- December 29, 1958 Organic hlcrar C TOXICITY REPORTS ON OS-95 On February 2o, Mr. Garrett forwarded a copy of the screening toxicity data on OS-95. As you know, since that time we have had some additional work done and copies of these reports are attached. The report dated October 20 is a repeat of two part3 of the procedures done originally; that Is, akin absorption or akin penetration lethal dose and skin irritation potential. The data confirms the results of the original screening studies. More recently we have received a report on a limited study to determine the toxicity of decomposition products of the fluid. A summary of this work is quoted below: Group A: Exposure to Moderate Mist (Six Hours Total) All animals survived the schedule of six, one hour ex posures spread over a period of two weeks. Copious nasal discharge, salivation, lethargy, and moderate weakness developed. The fog caused considerable inflammation and discomfort but the cumulative effect was not lethal. 'Group B: Exposure to Heavy Concentration of Mist (Fifteen ___________ Minutes Total)___________________ ______ No deaths resulted from fifteen minutes exposure to a heavy concentration of fog. There was irritation but the animals were not in danger of collapse. Group C: Exposure to Heavy Concentration of Mist (One ___ _______ Hour Total)________ Collapse and near collapse developed in the latter stages of the one hour exposure. Ho deaths resulted. The animals were moving about in fifteen to forty-five minutes after exposure. Weakness was evident for several days." On December 11, Dr. Kelly sent you a memo with an attachment en titled Ob-95 Toxicity statement". Copies of this correspondence are attached to those who were not copied in originally. DSW 586045 STLCOPCB4091379 Mr. H. 3tu Lltzaihger--Page 2-r-Deceaber 29, 1953 This statement was prepared by Dr. Kelly and me after you in i'omeu us that there were some plant workers who had quite continuous skin contact with Pydraul F-9. Hie degree of ex posure which we talked about was comparable to that of an auto mobile mechanic spending b hours a day tearing down, repairing and reassembling automobile engines. It was and is my opinion that such a degree of exposure to OS-95 could lead to skin difficulties in workers. We would not expect that this would oe of the dkydrol 500 type but rather a combination of the de fatting action comparable to that with paint thlnnera and seme absorption leading to production or development of shloracne. As a result of our conversations and Dr. Kelly's suggested OS-95 toxicity statement, I believe you have included in your report turning tills product over to Sales, a statement that emphasis must be given to avoidance of skin contact. With this I highly agree. Mr, bands has since called me to discuss the implications of this recommendation. I told Mr. Sands that our concern about the use of OS-95 is in line with our recent thinking concerning all fluids incorporating Aroclors in the formulations. The Medical Department does not recommend any stronger precautionary statement on labels for OS-95 than has been recommended recently for other fluids containing the Aroclors or, in fact, for the Aroclors alone* To do so would add to the inconsistency which appears to have developed in most of our recent thinking and opinions concerning hydraulic fluids. As you are well aware, the precautions which we in the Medical Department recommend in an effort to prevent difficulties in the use of our products must be based on an estimate of the exposures of the people using and handling the fluids. X personally have never seen a diecasting machine. Dr, Kelly has seen one or two small ones at North American Aviation. From the verbal descrip tions of such equipment provided us by Sales and Development personnel, it would appear that prolonged continuous skin contact could be avoided. This was what we had expected with the Skydrol fluid only to learn that such was not the case in every instance. As we became better educated or better Infomed as to the degree of exposures, subsequent opinions must be related to these ex posures . In summary, we would not recocssend that any of our fluids be handled as If they were non-toxic" petroleum lubricating oil. The fact that this may have been the case for a few people with Pydraul F-9 and no difficulties have been experienced does not lead us to condone this practice. For this reason we do not believe that the sales approach in attempting to substitute CD-95 for Pydraul F-9 should be that "If you handle 03-95 the way you have been handling Pydraul F-9, you will have no difficulties'. We do think that if potential customers are told that skin contact must be avoided in accordance with our recommendation in the past DSW 586046 STLCOPCB4091380 Mr. H. 3tu LitasIn^er--Pag 3--Decesber 291 1958 that auch contact be avoided with Pydraul F~9 there should be no serious problems. iP^tdh Attaciisaenta * deceive copy of report hlmer P. wheeler DSW 586047 STLCOPCB4091381