Document ZJNOdjp0zwp28z8oqrRqOBRQY
Submitted to:
BIOSEARCH, INC.
p.o. box 8598 Philadelphia, Pennsylvania (9101 telephone: (215) 8 4 8 - 4 4 9 9
Project Number -- 78--1161A
3M Company 3M Center St. Pau1, Minnesota 55101
Materia]: Sample Received: Date of Report: Test: Object of Test: Method of Test:
Resu1t s :
3M Company - T-2038CoC
1/5/78 Study Initiated: 1/9/78 Study Completed: 1/16/78
2/ 2/78
Primary Eye Irritation Study - Rabbits
To determine the degree of irritation, if any, which the subject material may produce when instilled into the eyes of albino rabbits.
The methods employed in the testing, evaluation and in the grading of the test material are those described in Section 1500.1*2 - Hazardous Substances and Articles, Administration and Enforcement Regula tions, Federal Register, V o 1. 38. No. 187, P. 27019, 27 September 1973-
The sample was used as supplied.
Six healthy young adult albino rabbits were used in this study. 0.1 gm of the experimental material was instilled into the right eyes of the test animals while the other eyes remained untreated to serve as controls. The test material was not washed from the eyes.
The treated eyes were examined at 1, 2b, 1*8 & 72 hrs. & 5 & 7 days following instillation of the test material into the eyes. Interpretation of the results was made in accordance with the grading system outlined in the "Illustrated Guide for Grading Eye Irritation By Hazardous Substances".
See Table 1.
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3M Company - T-2038Co C, Primary Eye Irritation Study.
Conclusion :
Based on the accompanying table, the subject
material Is not a primary ocular irritant within the definition of the Act-Reference: Section 1500.^2 (b) (1) (2) P. 27019 and requires no cautionary labeling with respect to that section.
Karl L. Gabriel, Director
Ph.D.
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TABLE 1 Grades for Ocular Lesions
Mater Ia 1: 3M Company - T-2038C0C , as supplied,
Rabbit No.
1 hour 2k hours
hours 72 hours 5 days 7 days
1 2 3 k 5 6
1 2 3 k 5 6
1 2 3 i* 5 6
i 2 3 k 5 6
1 2 3 k 5 6
1 2 3 k 5 6
Cornea Opacity Area
1k 1k 00 1k 00 1k
00 00 00 00 00 00
00 00 00 00 00 00
00 00 00 00 00 00
00 00 00 00 00 00
00 00 00 00 00 00
Iris
Conj unct ivae Redness Chemosis
Di scharge
11 11 01 11 01 01
01 01 01 01 01 01
00 0. 0 00 00 00 00
00 00 00 00 00 00
00 00 00 00 00 00
00 00 00 00 00 00
1 1 1 1 1 1
1 1 1 1 1 1
0 0 0 0 0 0
0 0 0 0 0 0
0 0 0 0 0 0
0 0 0 0 0 0
1 1 1 1 1 1
1 l 1 1 1 1
0 0 0 0 0 0
0 0 0 0 0 0
0 0 0 0 0 0
0 0 0 0 0 0
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