Document ZJNM17Mp9O3z3J47d8eVm9Gp7

FILE NAME Industrial Hygiene Foundation IHF DATE 1937-1957 DOC IHF100 DOCUMENT DESCRIPTION Reference Cards Leet 1. DIGEST 1937 . CLAssivien SUB sec, HL. 7 [Bf it~ . |] . Rly 45 i| Aurnon CLASSIFIED SUBJECT ano 1239-112739-17 SY* ei TITLe: R.L, Thorne g Var Cott ~ Ri: AL USTR, < a re Inn c bal Or POSITION R.B. Fisher a RESEARCH AND ADDRESS RESEARCH TITLE Paligorskite Paligorskite TITLE Paligorskite cy. RESEARCH | RESEARCH SERIAL DESIGNATIONU.S. INDUSTRIAL PUBLISHER INDUSTRIAL Inf LLURT Mar Mar Marg, ) ILLUSTRATIONS Possible Cott ashestos INDex MAPS MAPS : DATA Sa * = OC ry@ (o) ABSTRACT ABSTRACTABSTRACT ABSTRACT Paligorskite 4 is isis probably probablyprobably probably | FELLOWSHIP FILE NUMBER FELOWSHIP FILE FC SP 752 NU MBER 752 752 Paes earns saan cee TE se are oe a ITO, & pF. 0y foreaeLost 3TITLE PA ' PE Moarts) , : Jilker Jilker Jilker Jilker :' i i; 1 : giswv %: j: Cs on : i: . PITTSBURGH PITTSBURGH aLdy PITTSBURGH : { ABSTRABASTCRTACT oi PITSBURGH ABSTRACT The of PITSBURGH The charctercharcter character Lharoee The asbestos oN irs N versal asbestos textiles oF 'c ao } ie PITTSBURGH . ABSTRACT ont cf ry a The 1 is iEke s # S _O - character character suchsuch such that that character character of asbestos asbestos asbestos nipt conclusions A NS Ni OU by & other coveringcovering other other operations FILE NUM :~ - at ui z= >o J Dar CL ree Authors AuthoF rs FR conclusions ee sons seers nen it neeicor fo m rm a er t s rome oo . 7 rr : ! of within Particles under readily favour the retention particles microns in length restricted cellular - the somes Ate ee mee te me ee we te ee, lungs 5 - et nee, 5 for the reason that they were more motility more than larger particles would wandering phagocytes are phagocytosed It seem that rarely able to ingest particles larger than 10 microns Giant cells sometimes formed in tissue fusion of two or more ordinary phagocytes and cultures apparently by larger particles was or clusters of particles were then able to engulf 6 There no evidence of the formation of asbestos bodies in these pearance of brown granulur experiments experiments experiments nor have we noted the ap- animals pigment like that seen in the lungs of animals . experimental . H . t : . } : : ! : : . . { } -- Authors } sudary . a! ; : ia H : | - : - |! . ste e cee t dete wie cee : wenn o ' i mewnns I . Sosert de mee ae mee te me be i es cee ems elec. i wee ee . seemummees eet pee . i ee ee 7 a es H| el a -. t \ ~e Atf, 4 0-4 tex 77 FORM $ 409-4 =a eee 47 409-4 409-4 47 e re e te eye meee er aa Ean hae 7 Serae : | FELLOWSHIP NUMBER ens a PT Seen: EE oom - FILE NUMBER 752 -- ace AUTHORI L. Noro nme ee TITLE Histology of asbestosis Pa ORIG REP.1 ; VOL " DATE ; ABSTR REFS VOL PP DATE ; Acta Pathol & Micro- 23 | 53-59 | 1946 | | | ; _-!- -- - biol Scand ae _ _ . Pitsburgh ABSTRACT Two workers in an asbestos factory died under circumstances which indicated that the cause of death was their trade When the workers of this factory were examined roentgenologically asbestosis was found in 65 per cent of the 167 workers examined The microscopic picture of asbestosis is characterized by a reaction caused by the needles in the tissue which be- Instiue comes manifest in exudate cell infiltration accompanied by numerous giant cells containing foreign particles and an increase of interstitial connec- tive tissue and fibrosis Noro is inclined to think that in the pathogenesis of asbestosis the mechanical factors are the most important although the chemical factors may have some significance in a later phase J.A.M.A. ' Melon : - emp : veepaees weed eee oe er ae oe eke ee e k bes gee were 8 we e Freee t Q DATE EXAMINED . . Y rot . PURPOSE OF SEARCHI ABSTRACT BLANK FOR GENERAL USI ' . CLASSIFIED BUCT / ; | . ; ll be hee | FELLOWSHIP ee FILZ NUMBER AUTHORI Luton Champeix and Faure TITLE -_ Asbestosis of the lungs Pa ORIG REFS Arch d ae : VOL me - .. DATE 299 ff 1946 ARSTR REFS Occ Med VOL PP DATE mal profess.7 | | ABETRACH Latte. neg A review of the literature reveals no previous cases of asbestosis in PITSBuron France but the authors have seen several cases in a factory in which asbes- tos is used and in which they make regular examinations Details in one case of a man of 64 exposed to concentrations of 48 to 62 are given dust per cubic meter total silica 40 and free silica 4.3 to mg of INSTI UTE plaints of weakness dyspnea coughing and loss of 14.6 Com- 1943. Thoracic weight were noted in INSTITUTE expansion was 2 cm In the sputum asbestosis bodies were found but no tubercle bacilli Roentgenography showed much than usual in the lower third of the lungs symptoms became more more fibrosis During the next two years the severe Melon -- From Occ Med DATE EXAMINED EXAMINED - ~ uo . av, . . FFR FFR T - ~ oo PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE ad COCON NT'D T e 'e D ere Mee erent te ecean ceppenm tigi te nm ance ot eeoeceaahe gepMmrettER EN OME Pt aPC RAE Oe of weeemeemnrnes vers om ee. e amen! ti ante "" ee OR Se AR Re pee Hae ey, ( I a407e-4 47 | FELLOWSHIP CLASSIFIED CLASSIFIED 407-4 407-4 met 47 a J NFC KUMBER FILE 407-4 / 47 and X AUTHORI _ Skavlem R.J. a TET ee 7" ee = my eg me ee . ere crea R.J. Ritterhoff 2M NFC oe Te Cn asbestosis sarcoidosis sarcoidosis - Re Ne _ eer: eee, NUMBER NUMBER ee 752 Oe ee Terme lee, OMS. : Pa Am.J. Path, ' Path > Am.J. 22 1493-517 JIH Yoo, . ~~ _DATE DATE 46 46 REFE .; JIH ~~ Mar. 29 Mar. 147 2 __y ris d^' 8 ; . ; _. . " E necropsy report of a dyspnea respiratory a Proviously 5] E a ABSTRACT This is necropsy necropsy a year old man died respiratory : increasing death after 11 months increasing increasing severe exertional dyspnea the patient had worked years in an asbestos plant pathologi- pathologi- study coexistent asbestosis and sarcoidosis both lungs lungs J.I.H. T ee mee. = ) Tet ee eee, To ete mee eee, wove wp mee bee an ce wee me see! wwreei og ee we, oe ee 2. ho : NES ree nee oe - : ~- Smee = el - Le de tn Lee fs fen. weg C& . wtheee : aes ; we dan soa r 2 2 1k : . : - | - oo . _ | . . . : : . . \ CONT Ds een : ABSTRACT BLANK FoR CENERMAL Vos bd } a aa - an ~~ -  4234-2 47 eb | / Eleni oS a alltCRON | al as TODS Ms ME. Lh MB Fs eS cee | FELLOWSHIP NUMBER NFC t AUTHORI E.J. King J.W. Clegg and V.M. Rae FILE NUMBER 752 TITLE Effecotf asbestos and of asbestos and aluminum on lungs of rabbits _ Pa ORIG RE75 _ = ; VOL . 7 DATE ASSTR REPS Thorax eee 1 oe 188-197 Sept. | JAMA oo . , VOL 133 aa _ 208 DATE Jan. 1 1947 Pitsburg ABSTRACTI The purpose of the experiments described described by King and his associates was to test whether short fiber asbestos is less damaging in the lungs . of the rabbit than is long fiber asbestos and whether metallic aluminum will suppress any toxic effect produced by fiber asbestos Four groups - of animals were tested All groups showed a foreign body reaction in the INST Ue lungs In animals in the long fiber experiments there developed a nodular reticulinosis comparable with the experimental silicotic nodule In ani- mals in the short fiber experiment there developed a diffuse interstitial reticulinosis The addition of aluminum did not afford any benefit in any group - J.A.M.A. . Sete mares cemcwe 6 same a oe os pms pean pe tee cme etm me weeee GF : Melon ce meee ee memo ne cee tower eee Fa dete aca ee ee epee poe ne. Meee eee we. aren - ~ Bee ee ie bce ete ee ee ee Deen - eee coe al 8 eee EXAMINER E. FER JAMA ~ PURPONE OF SEARCHI we tee " ABSTRACT BLANK FOR GENERAL Use ne eee -~ o- ee ee es oe . oe ( ee -_ ee on PELLOW SHIP PILE NUMBER oe OY _ | pUMBER PELLOWS FILHE INP UMBER 1045-9 1045-9 Wegelius ee asbestosis AUTHORI AUTHORI Wegelius 7 wee tenet observed in Finland. lungs cases nT :( < . Changes Changes in eee ee VOL - in lungs 126 DATE of cases asbestosFinli and s pat vou. ABETR. Rere. C: aI , ORIG 28 . JIH Pittsburgh i oy Radiologica 139-152 ~, _ a E se a: 5 asbes- . ., ~ ferential _- on 2 3 io 2 a m my & 4 z z kB = ; : industrial disease not often hitherto Asbestosis hitherto Pittsburgh Asbestosis the lungs is an industrial disease often hitherto observed observed Scandinavia only fiveascbaessetsos been published published Norwestablisa hed a yn considerable In Finland where where established established of the industry has appreciable of decades asbestosis lungs appears appears occur occur an appreciable appreciable extent The author gives an 126 cases of asbes- tosis . 94 or 75 of these cases being the mild % in the moderate lungs ||. or 7 in the advanced stage The The roentgenological roentgenological and 9 roentgenological of the changes of asbestosis asbestosisthe dif- im- ; characteristics in different lungs ~ portance diagnosis the classification discussed different stages and im- stages of asbestosis time of exposure are of the lungs are illustrated detail The different pictures =~ a Author's Author's asbestosis oo, a . - Le es eee Author's summary Sane bem ore wee eee : iz corny e CONT EXAMINED eens nemenmten WER GEARCH i EXAMINED! TCR | DATE ev: summary PURPOSE ame OF GEARCH BLANK GENERAL GENERAL USE ~ ABSTRACT 5 & & tens ben gente ne rtg ap ah |ad phon RENN are min ne, : CLASSIFIED SUBJECT J 1 : - : - FELLOWSHIP NUMBER FILE NUMBER | AUTHOR TITLE P. Luton J. Champeix and P. Faure - the The significance of | of asbestos bodies in the sputum of presence Pa ORIG REFS asbestos workers VOL PP mee DATE ASSTR REYS . ee ee een VOL . PP DATE Nov. Arch malad profess.8 | 56-58 photmicrgaphs 1947 a Ind Hyg Index . | |1 3-4 Nov.- PITSBuron ABSTRACT 33 ref 7 photomicrographs worked asbestos " The authors examined 176 per whos woro kedn or s had worked with asbestos They find that asbestos bodies appear somewhat early in the sputum of these workers sometimes after only 20 days from the time of exposure These fibers | may persist even after cessation of exposure but occur in almost all workers exposed to asbestos dust whether they exhibit functional or radiographic evi- InstiuE dence of asbestosis or not Brown or golden yellow bodies are seen in the sputum along with uncolored fibers or spicules The presence of these bodies more or less scattered indicates that the subject has inhaled asbestos dust but it does not necessarily signify that asbestosis exists In other words the discovery of asbestos bodies in the sputum is only one in the ensemble of Mel on elements which permit such a diagnosis It is true that in the cases where asbestosis is predicated by reason of the intensity manifestations and radiographic signs numerous asbestos bodies majority of of functional are noted massed together and displaying a rediate formation As such they are iden- tical to the clumps that are observed on histological examination of the lungs of DATE EXAMINED deceased cases in the FFR Ind.Hvg Ind.Hvg alveoli PURPOSE OF SEARCHI -- Ind Hyg Index Index ABSTRACT BLANK FOR GENERAL USE ee -. : a eee ee mee ee t i CLASSIFIED CUBJECT omnes cee pe tern qummrnneir Ns Heer meme te te AUTHORI TITLE 142 nem me ee RRO oe MM o emt Anon Safety Rev. U.S. Nuvy eb ee cee Asbestos dust . - oo. FELLOWSHIP NUMBER FILE NUMBER ' 752 PA ORIG REFI YOL ANSTR RKPS Safety Rev. A 13 Jan.147 | PITSburgh ABSTRACT The brief article calls attenttio othne hazard of exposure to asbes- tos duct and the need of adequate localized ventilation All working places with possible exposure should be checked for asbestos dust and where mechanical exhmist ventilation must be supplemented by wearing of personal protective equipment it should confortmo Bureau of Mines specifications Instiue ~t i . or : . ew. : 14 . oar re er er MELON ~- - : ; . Td . PURPOSE DATE EXAMINED EXAMINED Bre FFR FFR OF SEARCHI ABSTRACT BLANK FOR GENERAL Use CONT'DI CONT'DI eee - . ow - ae Co be a. do a at ee seaibeahimitentatet teats Xs ARTs O.. e SE AUTHOR: 752 AUTHORI Pa, ORIG. NEFg,, T.E. Belt, J. Friedmann E.J. E.J. T.H. Belt J. asbestos tissue tissue effect effect coal dust King cultures FELLOWSHIP NUMBER FC NUMBER NUsmaeR . 122 comparative comparative with witr Te oe 9 eae aie quartz esa quartz quartz and coal ORIG REFS & Bect. VOL | J. Path DAYR RETS.1 RETS.1 ABSTR me ee IT IT IT I DATE 159-164 1947 ABSTR ApsTRACT, ste ee MErILirINsTOSBuNrUnR,gn phPahgaogcoyctyotsoesdis asbestos character asbestos : even of small particles wee te ere o, wee in 1 Phagocytosis Phagocytosis in tissue a considerable portion the place approxi- approxi- cultures cultures cent remained mately per untouched experiments Compared though the abbestos phagocytes phagocytes within range asbestos less throughout with coal quartz readily phagocytosed phagocytosed particle size being equal little or no toxic effect Asbestos particles particles in ) Asbestos cultures cultures small small amount fibroblasts fibroblasts on living accelerated accelerated no The growth growth observed was neither retarded nor asbestos necrosis of cells as a result of contect with asbestos appeared to occur more fatty phagocytes slowly in asbestos phagocytes coal Asbestos particles underwent visible and in phagocytes visible diminution in size after having been ingested ang in particular for for long as five 4 weeks motility of wandering phago- red phagocytes phagocytes decreased after the 4 The particles particles This cytes necessarily necessarily toxic ingestion of deleterious deleterious This effect of toxic not necessarily lungs since restrict be case cells migration of cells 77 it tends to restrict the cells so so 5 AaTe Authors migration of cells CONT'D CONT'D ron DATE summary ov, SEARCHI / OF GEARCH, CONT'D: ecemernee ABETNACT BLAKK FOR GENERAL ues * .a aan _ + Sthan generalgeneral incidence in cases of mediumor advanced asbes- .~ tosis This figure is in accordance with the experience of other workers and calls for further study Tuberculosis occurred in six cases but it is _. suggested that this incidence is not significant this is not quite con- ( ncing Gardner stated that experimental asbestosis does not predispose _ tuberculosis Unfortunately the occupational histories of these cases _ _ are not \ . : complete Hy : : came eee 4 . i Ce : a ; { . . -- Brit J. ' { . Ind Med 1 } | mw wheae ene ~ be me : ob i ~ . | meres Le - sods - 4 on 's - aoe - _ coeere Sat . aa : : 4 - Seeman ft net 3 ae ' : t- - : 7 : ! ~- wed. | en eee oe re te a ee ee eee abe | es | . i. . am cafeence ee 2 ~ . oct wee . of rn os { t : : : . oe - - t , we te { t ~e > : ! = . - wee | we : ee t : - se Meee ee a ee { ee ee { : mo ere t ! < }~ te shoe | +: - i coe - | t i i, = \ ! a \. : , ie Do - . 1 i i : - ' . ' - _ .| ' H awe ee Jd. sone! | bee 1 i i - +: . ; t : te . : ae ae ot . a ven b ene | 5 Reece: : : i i - we ' t bee i ewe eee comb: enna enon meee! oe. te moe . eee. ere ; : \ : : . : are ne ne a ~ s +e a wie eee 4 + { 265-7 265-7 |18 -a FELLOWSHIP FILE NUMBER 752-337 752-337 mms Some medical problems of the asbestos cement industry PITSBURGH Brit J. Phys.Med 20 50 PITTSBURGH Mar. Occ Med 1947 Apr : ||an Oct. 468 147 Loewe only te two only PIT SBURGH INSTITUTE | - INSTIUTE INSTITUTE BSTRACTI cases of asbestosis and only two enco autu hornet ncoe untr eree d d no incipient in an or three of standing chronic disease in five years experience ade- asbestos cement factory showing that ventilation and enclosure were in caused Cleanlines quate A dermatitis occurring some workmen was found to be other than the asbestos Cleanliness of an abrasive constituent the cement it and the use of a barrier cream were effective in preventing INSTITUTE _ Q-4F +{~ a7 pune MEMELLLLOONN MELLON DATE EXAMUNG - meee es : +. we : FER m~ OF SEARCH - ABSTRACT BLANK FOR GENERAL Uss CONT'Dr CONT'Dr ee - _S \ tetas ~ : \ . a i ee ' ios los FILE AL, i Pulsa, 388-/ 8 48 48 les oe Shigeo ~ * OSs 2, Te . | NUM arse Fle Ny . Reusseay . NM. Gs HFC 4s. lw. [" Ee Pa } 48 LBs ; C Giroux mo ~ 3 EE|BII} |progremsocsonioAssbieessxtopsiesrimeenxtpesriments tuberculosis 1947 imasbestopsisaosBrirt bteaGsnattrodsniesr's producticon a120ses i | i " C.C . Qi]| MIENLSLTIOTNUaTsE bestosasibesstosaisre suppolrutng described britefhley oprroyduced experi- , ft PRG. neve, L. , L. Rousseau Rousseau M. Soiris SOUP g G 50%. Bop. pulmonary go TITLE Asbestosis Asbestosis wens. TITLE pulmonary . (Praca 4a REF3.1 ) SH DATE re] ORIG St ~ ~ 23 7) f-san vn OAT m Igy NETE wale ABSTR NETE wee ABSTR nee, . J. Sem -1947 Ind Ind a French Med | ~ a FITTSBURGH QGuueebbeacn 5 3 sptatermenotsdustatemcentstion fad of | INSTITUTE the of by C ais although produced asbesto- ~ ! Hi French 5 FITTSBURGH French French _ Tot ; 1200 Pp. | Apr. . TOMert Apr. ACSTRACTI aes FITTSBURGH dhe Iron . The report asbestosis one od and Apr report | Theanimal the preu- L and INSTITUTE bodies INSTITUTE tuberculosis Gb + of also fboordieausthors MELLON t moconiosis progress animal the giving asbestosis pulmonary tubearscbuelsostiossfromnot witthhat duecuthors They dis, agree cuthors asbestos pulmonary pulmonary pulmonary pulmonary no from They asbestos iis s tuberculosis Quebec disagree ; tuberculosi velue tuberculosis diagnosis sputum described death described not support velue descdreisbcerdibed one , disagree an and and that diagnosis important the death wwasas statements Gardner's statements factor the presence the Several presence presence presence cabostosis cabostosis cabostosis cabostosis cabostosis of of authors proof described are briefly asbestosi with cancer lesions also described were that asbestos asbestos Several asbestos bodies ang bodies bodies Two cases cases animal experi- guinea experi- oF t %, a La Zz 2 fe Pemprgenoee cam ee 2een meen) SR gy ce roe i . : we - cee i . bodies bodiebs odiebsodies th th same - area mi 1 which mi bestos bestosbestos bodies wwereere found found found bleed had of bleed had been been after month after a month He He considers asbestos aasbesstosbestos iinn thethethe bodboidieess lu lunnggss . in sputum sputum has significance significance significance since ~~ immediately immediately immediately as lesion lesion injected injected injected before into into into before immediately imediately before presence as- of tissue demage demage Ci - oom ee : , : : -- ! : ween me me te Mod : t - - : ; : - : ' : i i "4 i : . ctw mn one : i i : i . + . ! - . ! : ! {. 1 : i. t H i H o : . : . . _ . oe : . i H ames : a . ad : . 5; a , et wee be i . ! : : i : H ve . | ' . . . Poreery =i ~~ ee i. . + ! : : H .i wo i .: - ~ m toc - t : : bo... : i 2 i t i : o*: . : -~ > : | ee : ' * : . >; ot t : ' on : . : ! - ' ' we i . i wee ' ' ee ory ; serene meee femmes ne : : ' ! ' i \ t : fo : , | : | | , -5 H 8 i } i t : : . ' we i ee ee eee : : ! . ! ( Neo f ve eee, cogs peecucsennn waseyommot on eas eee sm eeareraneppeipeerrenreme age oe stetmenennmrecabeae rem aer ? 6-9 = - AUTHOR P. Luton and J. Champeix | TITLE TITLE .. Asbestosis - Pa NFC | - 752 | Arch Mal Prof | 7 365-378 1947 . | JIH = 29 ! 91 Sept. Pitsburg ABSTRACT The authors list the following symptoms of asbestosis 1 Functional signs 2 Radiological findings 3 Sputum characterized by the " presence of asbestos fibers and bodies After a presentation of several case histories and their accompanying ray films and sputum photographs , it is concluded that diagnosis can only be made by a combination of ob- INST UE servations functional radiological sputum Because of the nature of the disease yearly examinations should be made with of the measurements of respiratory function spirometry etc. progressive comparison and rays But functional signs must guide the physician when a change of environment 6-4 MEL ON is advisable and when the worker can be said to have contracted asbestosis -- From J.I.H. 16M - i oa as che me) Came memes een wm + ee ene oe a ny le + ee we, Semen vee se e eam ree) ee ers sae 77 . DATE * 7 PURPOSE one bee eee 8 : ween CONT'DI . FORM EXAMINED wr WFR From JTH OF SEARCHI ABSTRACT BLANK FOR GENERAL USE CLASSIFIED SUBJECT FELLOWSHIP NUMBER Sindenidetneeee, FILE NUMBER AUTHORU Vv K.M. Lynch and W.M. Cannon _ Pee oo, 752 _ TITLE Asbestosis VI Analysis of Forty Necropsied Cases Pa PD eee Tm tee eee ed oe - 1948 Dis Chest 14 Brit J. Ind Med 6 DATE 874-880 | -- [ or e we 268-269 49 _ _. Oct The authors report an analysis of 40 cases in which at necropsy Cases are divided into asbestosis was found ~ PITSBURgn minor medium and advanced grades the advance of the disease and the prominence of direct asbestosis bodies showing a of , relation to the duration exposure In 4 of 14 grade pulmonary tuberculosis tuberculosis was the cases of advanced cases of recent primary cause death Only in for Gardner's exposure was recent fibrosis found this providing support belief that fibrosis does not cessation of progress indefinitely after Instiue exposure Presence of asbestosis bodies is not invariable in experimentally produced asbestosis but is more typical of human asbestosis Lung damage occurs before the formation of asbestosis represent an attempt by the tissues bodies which may in the lung indefinitely Pleural to segregate the particles they persist Melon invariable feature of fibrosis is an outstanding though not WW particles do asbestosis the reason for this is not clear as the not reach the pleura The occurrence in asbestosis of nodular ene fibrosis of silicotic type which King and others have 77 tall was confirmed in 8 produced experimen- cases Carcinoma of the lung occurred in three TURN oEuXtAMIN oEfD 40 cases incidence of 7.5 per cent which is seven times awve OF SEARCHI greater , | ABSTRACT BLANK FOR GENERAL USE t y. : tA No . a, \ ween, 25.2fe]P oars ee atwe ofa cod wt ad f om ..d c*: 3- oO Phanci =2a% ~ a A Phanchini fy2 te4 . uv ced : NFC $3743oFaILEFEILE FILE of F % p: Po betweneextcnosinveomicthe asbetosi features features asbestosdescribedauthor's prohylacttihe prohylacti genralyprohylactiprohylacti genralyawrens awrenthsrapeutic therapeutic and extensiveextensivextensive econmic asistance featfuearteurses The workers awrens trouble disprortiontreatmendtisproportion disproportion from . BuringBuring Buring Buring lungslungs were were found found r seat seat of of 3 extensive extensive asbestosis author's author's . the disproportion disproportion disproportion - asbestosis asbestosis asbestosis author's author's direct direct disproportion features between gross gross described described described described described attentiaowanreness awareness of of trouble trouble GO rf results results results prove importance importance importance importance importance of prophylactic therapeutic treatment reatmentt reatment oO assistance thethe asistance se prophylactic prophylacticprophylactic therapeutic treatment economiceconomeicconomiceconomiceconomic as istance assistance as istance assistance to asbestos asbestos asbestos workers workers 4 general y generally particularly particularly those those ct Indparticularyparticularpyartictulraey particulary insulatinngsulatinmgaterialmaterial material material 4 -- Condensed Condensed Condensed Arch . &Occ Med atmentrament ArcAhrch Occ a6ad : q 9Pe) & ro] <4 , - treatmePnto Jo e e q , rygoJ oO s toy Laugy Ow<uhe& zi z| ' 5r : | 7 | | | | . | : | I Dyiperres sumer Z - a seme, mee | C CLASSIFIED Tore 471 471 867 149 Eqit+ 867 ad TELLOWSHIP | NUMBER Fc FILE NUKER 752 752 7 AUTHORI Editorial and Cencer of the lung 4, . Pac, REFg., mH, a JAMA, VOR, PP, - Pa AS seSrTeR .. - on. . 1401219-20 13-49 PITTSBURGn J.A.M.A. 1401219-20 1401219-20 1401219-20 a, 13-49 13-49 | ee Pirsnurg Cancer oF the Lung Cancer Aug. 13 aie oe see Editorial 1949 - PP pr.. ; | ca.ne ; Records of TL UTE, Report Records Records English American and German Report English Report Inspector of Fectories physicians in 1947 show that Chief Inspector of the lung is England pulmonary asbestosis asbestosis . the occurrence occurrence This This supported by the related to pulmonary incidence follrring relation is supported supported in asbestosis observations 15 tires incidence population 2 thpeatients female female ratio is mora e ogs an nearly general female indicates indicates that the environmental than evidently occupational population occupational carcinogen tended equalize equalize environmental rate cancer of the carcinogen Recent Recent the incidence lungs for both experi- support this interpretation of cclliininciaclalevidence . evidence, conr'o, _ \ C ee 7/49262671 7/4926276/74192626717/49262767/149262671 7/49262671 7/49262671 7/49262671 7/4926 71 7/49262671 7/49262671 7/49262671 7/49262671 7/49262671 7/49262671 I a. 475 475 475 475 AUTHOR =Virginia Cameron i oT ae ee | 414155 - ~_ < a NUMBER NUMBER FC FC ewes 2 FILE NUMBER 752 om o. te TITLE The Cost of Research on Tuberculosis | Pa Allocations in 1947-1948 Pa | ORIG 3.1 , VOL 60 PP. Tuberc An An Rev. Tuberc PIT EBURCU 1. weer eee oe 593-405 60 593-405 7 593-405 PITEBURCU 7 oo D> ATE 0.149 0.149 if in the United ABSTR PEYS.1 7 States H Analysis of VOL FP DATE - 7 PITEBURCU of PITTEBURCU 1267 The Cost of Research on Tuberculosis in the United States Analysis Allocations in 1947-1945 Virginia Cameron Am Rev. Tuberc 60 393- PITTEBURCU 405 Oct. 1949 The present research programs programs of various agencies are outlined and INFT UE their contributions to research on tuberculosis are summarized The total cost was over six million dollars Official health agencies account for 56.8 of the total manufacturing firms 32.8 and the remaining 10.4 is supported by universities foundations and voluntary health agendies Most of the commercial commercial firms are manufacturers of ray apparatus or apparatus pharmaceutical houses However other industries principallylight light contri-and heavy metal manufacturing and mining operations made a notable Melon bution ( 83,550 during the period Fifty percent of this amount was designated for research on silicosis and tuberculotubserculiosiss - nore Sa FORN . DATE * FORN EXAMINED BY = PURPOSE * re ee OF LEARCHI + ae . ABSTRACT BLANK FOR GENERAL USE . . : * . Pos CONTO CONTO :. rE we ape eerie enn meets cae cee semnmn ee _ af if 77 FORM CLASSIFIED SUBJECT e FELLOWSHIP | NUMBER | FILE NUMBER AUTHORI H. Ollivier P. MoraR.nBrd un TITLE Granulomata of the Skin Due to Asbestos Pa ORIG RES Ser eee Cee eee VOL P. DATE ABSTR REFS.1 DATE ) 516-517 Arch.Malad Arch.Malad Profession- Profession- 516-517 French | 10 wee eee 1949 || Bull Hyg 25 25 25 1482-485May 4 1482-485 1950 eee ee eee hand A man who slightly was working with Two weeks asbestos sheets wounded the palm of his which later at the site of the cut a swelling - Pitsburon was increasing in size appeared There was the swelling was hard at the center no inflammation and The small white nucleous of this core was seen under the together with a mass of microscope to be crystalline composed of needles of asbestos INSTIUTE as matter This matter was identified cholesterol which formation would seem to indicate biochemical defensive process of of the a fundamental and INSTITUTE body against aggression by asbestos + em eee ee - Condensed from Bull Hyg - - te ee Melon ter amet Oe Reemeene me ae eee oo A mre Foes ST TTT tt comme g mee oe menage ee ye emmmemerwene. fans ome em - a ' ene ae tee me ee ee yee oe me mee eee + Re oa me enmte ee, Ore Sneed | mee + wes on eens. ee rene omnes. se mmm aoe me ~ ammo cee tae eee oe game me ate Ae ee. RT ' mee ee eee | em eee weet eee tome eo tren an oe we i ee mem pe e e eo. Tks mewvenmme: 6 me 8 ne mes me pt mee ie owe -- -- ------ -- -------- ---- _XAMINED -- Ce BY: PURPOSE PURPOSE melee OF SEARCH te ee 8 wee - - o ABSTRACT BLANK FOR GENERAL USE oe on ~ - CONTO .. mnmenaayae owes . . ae a( : a 545 545 545 545 545 { | 7 AUTHORI P. Cartier Cartier i | * ome, 2 2 : we : } FELLOWSHED FELLOWSHED : NUMBER ! NFC eo nme 5 FILE ot NUMBER FILE NUMBER ; : 752 Pa oe TITI.E A Contribution to the Study of Asbestosis a GRIC RES wee VOL .. 89-595 Arch Malad.Profess 589-595 | Malad.Profess ) $ Arch Fr. 1949 1949 1949 AESTR REFS . VOL PT . Occ 9: | CATE | ^ | The author has been Mod . 3 428 4/51 in medical charge of 3,242 men asbestos mines in Canada where employed in Pitsburgn of asbestos is mined Cases over 70 per cent of the world's supply of Institute _ been employed for at least 14 asbestosis were found only in those who 5 million particles of years and exposed to air had _ containing at least 10 to 250 microns in asbestos fibers per cu ft the fibers being from mildness of length The outstanding feature of this any pulmonary trouble among the asbestos report is the Instiue reported in the United States and Great miners compared to that enr where asbestos is Britain as occurring in factories were present spun and woven No case of No clinical symptoms of pulmonary fibrosis was and no physical pure incapacity was asbestosis detected in those under age 60 evident Cases of tuberculosis were not more Mel on tfhreequent among the miners than among the clerical staff and the community although that incidence was rest of ascribe any cardiac affections high It was difficult to age at which it appeared present to asbestosis because of the Postmortem findings and late examinations indicate that asbestosis is roentgenologic the miners it develops so slowly as not a pathological entity but among is is no evidence that it to shorten working life and there = are predisposes to tuberculosis The conclusions by supported the opinions of experts at Saranac reached -- Cond from Bull Hyg roe Maristene rey - ; C Se. produce pneumoconiosis Gardner in 1938 suggested on the basis of animal experiments that the effect produced by asbestos was mechanical since it was produced only by long fibers A later authority made the observation that workers exposed to very short asbestos were not affected by it As- bestosis was officially recognized as an industrial disease in 1930. The | condition is thought to be due to blocking of the finer bronchioles by long fibers which seem to irritate the bronchial wall and cause fibrosis Tubercu losis and carcinoma of the lungs may follows as complications Recognition ; of the disease and precautions which have been taken have lessened its .. severisty everity and incidence oo Condensed from Bull Hyg FORM FORM . DATE EXAMINED a aoe cone vege eee Sonnae timt e Ma PURPOSE BV: OF SEARCHI - . ete te . - . - . 3 H t ; ABSTRACT BLANK FOR GENERAL USE | i ry ~~ TOSHILD TOSHILD SUBJECT y ; /a/ ' : i | FELLOWSHIP FILC NUMBER i: : NUMBER re | - we mi tee , AUTOR J. Champix and J. Bouteville NFC 752 PA a vere Electron Microscopy of Asbestosis CF ...5 . a _. a ae VOL ie . _. DATE Bodies and emacS s R REFE the Fibers Asbestos . PGH Arch.Maladies Arch.Maladies Profess 607 1950 . oo. . Brit.J. Ind.Med Ind.Med VOL . : 8| FP 198 DATE 17/51 i: Asbestosis bodies recovered from sputum have a central fiber of j asbestos coated with a colloidal gel which is ' Removal of the probably protein PI ES TPIPESETPIPESET " of the enveloping gel by micromanipulation reveals some transparency edges of the asbestos fiber believed to result from pI Fibers shorter than 10 microns solution are not found in the bodies and it is # suggested that the smaller fibers dissolve Iser t the authors suggest that pulmonary fibrosis cmoamyplreetseullyt fOrnomthsiosluteivoindenocfe asbestos rather than from some physical irritation -- Brit J. Ind Med Muna n Muna n CATE -- : -- ay: PURPOSE : UF 5.49CHI : -- : Se Ae Me ence | o: ae mt am ae et AbalACT NA FOR veering CONTCO ONTO ; CLASSIFIED SUBJECT 83 _ AUTHORI 152 = 152 | owe cerecrennen ean A. Bohme : eerie _.! ca ental Se ces a sas oS | FELLOWSHIP NUMBER FILE NUMBER + NFC H ey os 752- 752- TITLE PA Results of Periodical Examinations of Workers in an Asbestos Factory ORIG REFS VOL PP Beitrage z Silikoce 11 27/34 GermaGerman n Forschung Ld DATE 1951 AGSTR REFS en | Bull Hyg mse VOL DATE a. 26511 j 5/51 PITSBURGH 26511 2651 of r cee Since radiological supervision and oe in an asbestos factory in 1936 control measures were the dust hazard has been adopted as shown by comparing results of greatly reduced comparison different surveys in 1936 1940 and 1949 A spinning and weaving working places shows that that the risk is low in but high in preparation carding and brake A table shows results for 14 cases from 1936 to polishing INSTIUTE others did not Inquiries 1949. Some | progressed INSTITUTE tendency to progression afatemrontghe fdoursmter workers reveal little if any contrast to silicosis exposure has ceased On the other hand a personal personal factor This is in silicosis as number of workers do exists as in Melon dust exposures - not get asbestosis in spite of high Progressive tuberculosis is started in the parts of the rare only two cases being found both dede tion of asbestosis and carcliunnogmaleaosft tahfefected by asbestosis One combina- of this study is the demonstration lung was was found The main result KOJ ua control athat the hazard can be reduced by dust _ os Cond from Bull Hyg afm Lh an oe a 77 FORM /9 f@? G AUTHOR: of. a wat? cal AERIS eRe ise Ww. Behr ens vende Bete BED ess. ete ee am Tote e e a NUMBF rms 1S et Ge FELLOWSHIP NUMBER FIL NUumaAr NFC 752 Cotte ie ete 752 AUTHORI Behrens asbestosis > Pa, ORIG. RE er PS, voVuOL .eee . + tas PP. are cones pate REFS .: HEPS : Schweiz VOL 275- 195 path 1951 ACSTR _ Hyg Bul Bull Hyg , ; 26/18 12 . 26/18 2 12/5 pc, INSPTr^tUsbEu,RGH lengthUnsuccessful demonstrated r Pure chrysolite chrysolite chrysolite Ss tracheally Pure asbestos was ininjjected ected intraperitoneally tracheally mice and rats The fibers intraperitonealy intraperitoneallymicrons microns in varied standard standard length length length Unsuccessful attempts to secure fibers standard are in general picture is focal fibrosis are one of introduction of specific solution toxic resulting resulting from asbestosis could be foreign bodies Asbestosis Asbestosis bodies were ~ formed The theories of the asbestosis discussed discussed pathogenesis of from Bull MELON Hyg -> Cond from Bull. Hyg. . - DATE DATE By, a - fearedie ne wade PURPOSE ABSTRACT ABSTRACT ABSTRACT BLANK FOR GENERAL USE conto. tl etreeomen yo CLASSIFIED SUBJECT fl - fl - FELLOWSHIP FILE NUMEL NUMEL oo Nn C AUTHORI R. Stoll R. Bass and A. Angrist Pa TITLE Asbestosis Associated with Bronchiogenic Carcinoma | Intern Intern DATE Med 88 831-834 Dec. 51 | In Berman | | | Dec. TF AOSTR REFS Bull Hyg 27 Amt SN tnt ore canerntmency enemas!Oe mee eee ee La, VOL 444 444 Hot . DATE 5-52 Pitsburgi 5-52 pulmonary carcinoma are hard to found carcinoma in 7.5 to collect but three investigators have in which 14.8 of cases of asbestosis a worker had been exposed to asbestos for 6 A case is reported to wear respirator He years and had refused came under notice with weakness and INSTUE a persistent Melon metastases After death modules scattered throughout both varying to cm in diameter were found necrosis existed lungs with interstitial fibrosis Large areas of throughout the lungs inside and outside and typical asbestos bodies were the tumor areas Metastases seer brain and liver The opinion is were found in the kidneys itself be directly carcinogenic suggested that the silicate in asbestos must It establishes an additional ventivemeasures in the use of asbestos reason for pre- DATI ABSTRACT BLANK FOR GENERAL USE - | Cond from Bull Hyg ~ se + \ ee eu ete wees a, FILE NUMBER i AUTHORI AUTHORI J. Clerens TITLE PA Research into Pulmonary Asbestosis in Belgium ORIG REFO Arch Belges | 557-565 Bull sociale hyg legale ABSTRACT med we VOL LO 8 557-565 } 557-565 DATE sw AUSTR REFS i 11/51 med dultravaillet dultravaillet and Hyg . . ; . a . Pitsburgh a. 10 i 26 | enn | PP 402 | is - - - = The investigation concerns the vee ae oe asbestos crushed cement industry in which and mixed with cement Enclosed prevents most of the dust from apparatus INSTUE locations million 20 to 40 particles escaping in the most dusty 5 microns The workers per cubic foot were found with 50 under -. have been examined periodically over of three years Out of 75 men a period tae there were four doubtful employed for seven to over thirty years Melon indicating cases and only one presented ray shadows Mellon pneumoconiosis The man died insufficiency circulatory and details of of progressive mortem findings are given DATE 4/51 _- Sa ~r DATZ _EXAMINED _EXAMINED AY PURPOSE _ of ARCHI ARCHI ~ ABSTRACT BLANK FOR GENERAL . US8 ny CONT'D fl - fl - [7 nae. i ; . | 2 1 i : i TT ' -- -- associated Indurated nodules and asbestosis asbestosis asbestosis _ lungs but asbestosis bodies bodies were found no tubercle bacilli The bodies throughout the in the alveoli were seen in fibrous aged 49 had even even included within giant phagocytes zones This ~ been totally incapacitated with man cardiac failure In dyspnea on exertion and others asbestos asbestos 12 samples of particles were found in 10 findings were nsopt utum and asbestosis bodies in 3 samples but tohuet of _ The evidence is against muchwidangerth ray shadows indicating indicating fibrosis cement danger arising from the manufacture of CET ee T p: e E me ee hn Hyg -- Cond from Bull . eee ee Py 4 : R, H t t : i : | . : t Fe i CLASSIFIED SUBJECT i ; > - Vs fea et ee me ^' if vo. JJ Ee UF. = SS he SES 5 Sa Se , - FELLOWSHIP FILE NUMBER NUMBER : emma nfc a ae AE ER ad Bi ei Se 752 oaths. - . AUTHOR P. Luton J. Champeix and P. Faure TITLE A Case of pulmonary asbestosis with Its development followed by PA ray study ORIG REFS and its mortem VOL PP DATE + ASSTR REFS VOL PP DATE Arch maladies profess 27 942 629-33 1951 Bull Hyg | 10-52 cas The e case reported is said to have been the first one of asbestosis known to have occurred in France The man had been exposed to high con- centrations of asbestos for 11 years Symptoms and progressive ray find- PITSBURGH ings are described After death the lungs showed general thickening through- 4 out especially of the plurae but with no localized nodules Many asbestos bodies were seen isolated and in groups together with giant cells and min- E E particles No evidence of tuberculosis was found The dust particles could be traced not only in the lung vessels but also in the vessels of the liver kidneys and spleen i than chemical Melon . 4 ep one The re action of asbestos is apparently mechanical rather St a : PS col -CT ho Cond from Bull Hyg foe DATE EXAMINED re rm a ; BY: Med PURPOSE . OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONTO F ee mar a ay 77 FORM CLASSIFIED SUBJECT Fou Fou 212188FouFou | a ee *. = j FELLOWSHIP FILE NUMBER | NFC 752 I : se a atte a ee ee ee) ed AUTHORI P. Lepine and O. Croissant TITLE A morphological study with the elctron microscope of particles of Pa asbestos found in the air ORIG REFS VOL PP DATE AESTR REPS VOL DATE Ann InstPasteur rte, oe | Bull Hyg : ee 26 100010/51 PITSBURgu of Six samples airborneaidrborne ust from workplaces in Quebec where asbestos is used were examined with the electron microscope after removal of all but the most minute particles The dust was found to con- tain crystalline needles smaller in size but similar to those seen in an ordinary microscope these needles comprised 65 to 75 of the particles | Instiue The remainder consisted of amorphous particles mostly of serpentine The needles had a diameter of 0.028 micron they occurred in bundles about 0.85 micron or more in diameter Such particles could readily g^inaccess to the alveol and undergo phagocytosis with formation of Mel on the tissue lesions seen in asbestosis Photomicrographs of the particles ; i are shown ; _2- Cond from Bull Hyg rary on eee . : -. DATE EXAMINED avr : : : PURPOSE OF SEARCHI ABSTRACT SLANK FOR GENERAL Use CONT'D ee er soyer j ee FELLOWSHIP NUMBER | ah i es weet ee eS te, i FILE NUMBER oY es TRS eh acs eS _ SSS Oe oe, AS ot. as mai AUTHOR Reubens A. TITLE H. Bastenier H. Denolin A clinical and pathological study asbestoses PA = sa 8 ee, nfc ied oy 752 752 752 Decoster and R. of a case of pulmonayr PA Lo sAorcchiale 10 52 med travial sociale Burgh hyg ORIG REFS.I 4 . Burgh Arch VOL Pr CATE ABSTR ABSTR REFS beiges med 61-70 Feb. wee 271126 Bull Hyg 271126 - med . legale DATE 12- Burgh French 271126 A diagnosis of asbestosis must 0 || wo. exposure depend upon a history of occupational to asbestos dust associated with effects on the case is reported in which a respiratory organs A a factory with heavy dust woman had worked for 25 years weaving asbestos authors exposure The symptoms described are typical The compared this case with those of residual air is uncomplicated silicosis in the latter frequently increased expiration is prolonged and the respiratory capacity is reduced but maximum hyperpnea intense and anoxemia is rapid breathing is not so differences never so important during effort as in asbestosis are stressed as important when These the necessity necessity may arise in determining occupational origin of a case with obscure diagnosis M aleseen TL -- Cond from Bull Hyg 201 ran 27 : FORM DATE EXAMINED Ov: . 5 PURPOSE OF SEARCHI ABSTRACT BLANK FOR GENERAL USE CONTD . ean CLASSIFIED SUBJECT ~ FELLOWSHIP | FILE Nu ' | NUMBER _ vesstmtwnernceied nfc | 752 W. AUTHORI Behrens , Jr. . sees TITLE The clinical picture and pathology of asbestosis + Pa ORIG REFS Berufkrankh 129-40 DATE Pitsburgu Unfallmed u VOL 45 PP 179-89 June 15 1952 AESTR REF Bull ne 28 Hyg 28 1923-53 1923-53 ( , ABSTRACT ( . This os a 179-89 Sent 15 1952- 1952- Woon a asbestosis paper presents an extensive review literature of literature asbestosis Pitsburg including distribution and types of asbestos its mining treatment dust hazards and effects of length of exposure of the dust and use in different con- centration Symptomatology diagnosis and ray findings in the different stages of asbestosis are described Special mention is made of the association of asbestosis with carcinoma which is much cosis mortem reports from the more frequent than that of sili- INST UE of asbestosis there literature indicate that in 309 cases were 44 lung carcinomas 14.2 whereas in 2,204 cases of silicosis only 32 carcinomas were found association of 1.4 The experience of the , tuberculosis and asbestosis varies greatly in different countries MEL ON English investigators have recorded a high rate of tuberculous asbestos workers but is a infection in rare complication in America and the rate is low in Germany The macroscopic and microscopic IC 77 described and the appearances of the lungs are nature and significance of asbestosis bodies are discussed and an extensive reference list FORM dealing with that ' os controversial subject is given - extensive -- Cond from Bull Hyg _ CLASSIFIED SUBJECT y [7 oe ae ee mee en ae ce e NE r ee | eT FELLOWSHIP FILE NUMBER NUMBER \ AUTHORI M. A. Kovnatskii and others cece e. TITLE Silicatosis etiology pathogenesis and clinical treatment Pa ORIG RE76 __ o_o, VOL PP. GigiieSn ana it -- Russian , No. 8 28-32 DATE 1952 7 ABSTR REFS Chem Absts we VOL 4=6 , PP 114000 DATE 11/25/52 amare - A review is given of the disease caused by particles of silicates rather than those of the type producing silicosis proper A study of the PItsburgh disease caused by asbestos particles showed that the chemical and biological features are increased rate of respiration compensatory and in stages the level of blood saturation with oxygen is essentially normal although changes in the myocardium are evident on the electrocardiogram The tone of the veins is reduced and the permeability of capillary walls suffers a decline InST UE in a considerable number of cases This affects the oxidative processes ~~, as shown by the increase of oxidized glutathione and a decrease of total Melon glutathione tee a ee ey Sa cae: -- Chem Absts : . .: et wee bie I. DATE EXAMINED te BY: tt : ae . OF SEARCH i ABSTRACT BLANK FOR GENERAL USE e CONT D J. Ruttner ' Be 7 - Asbestosis bodies and asbestosis bodies me _ a DATE AESTR : TORIC RIFS Schwei Allz gem VOL . 1628-31 oe 15 1628-31 1952 REFS Ce MO PLL DATE Bulll Hyg 28719 Sept. Z. "| 28719 Pathol.u Bakteriol German German on =... . The literature on asbestosis bodies is reviewed Similar products were found by the author in a lung which only contained carborundum and PITSBURGH graphite the bodies were formed around plates and needles of carborundum The protein and iron which form the bulk of the bodies must come from Insti ute the lung tissues and not from the mineral matter of the dust Similar bodies could also be produced in vitro but they have not so far been found - in animal experiments -- Bull Hyg oO a aD 7 te 1 . Melon weeds i YT tonk : DATE : EXAMINED BY PURPOSE DE SEARCH ABSTRACT BLANK FOR GENERAL USE rN i t AUTHORI A. J Lanza . | 1 | FELLOWSHIP NUMBER | . FILE NUMBER TITLE Asbestosis Pa Paper read before Fourth Conference of McIntyre Research Found on Silicosis ORIG RES VOL PP DATE 1/1952 ABSTR REFS | VOL Pe. DATE PP 112 1/1952 1 | | | aw pointed Pitsnurgi Britain briefly The action of asbestosis on the body is out that asbestosis is regarded much more reviewed is seriously in Great than in Canada or the United States the British believe it is worse Instiue resulting than silicosis and often leads to cancer while from asbestosis is practically existent in America cancer Melon > ( 17 FORM DATE , EXAMINED EXAMINED BY: PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONT'D ceemecn ac 77 fa o re ; 605 115533 605 605 6 oe 60 Do e5 ee A. a Se hn AUTHORI F. F. Boemke StS, 05 . <a : end FELLOWSHIP | NUMBER FILE NUMBER | nfc 752 a ee ro Se fa st. TITLE Lung carcinoma caused by asbestos inhalation A Pa ORIG REFS .: VOL 2 __._ DATE AESTR REFS.1 . Med Monatsschr 7 77-81 German 77-81 1953 Absts 474471-35-10-5 betweenil | 471-5 -10- The relation in the lung and carcinoma Pitsburg dilection Characteristic fibrotic changes caused by asbestos deposits is discussed The lower lobies the site of pre- are the multicentered developments of flat epi- | thelium carcinoma -- Chem Absts Instiue . ao em ry ~ ce ry -~ ' Melon i a nee: eee we ee DATE EXAMINER EXAMINER EXAMINER hal me es oe eee . . . q PURPOSE OF REARCHL ABSTRACT BLANK FOR GENERAL USE CONT'D . CLASSIFIED SUBJECT 262 7 , FELLOWSHIP | NUMBER |FILE NUMBER | | AUTHOR . G. Farris TITLE Asbestos warts and other dermatoses in workers with lagging materials PA ORIG REFS ween Rass med nee, ind 2 VOL PP 1-17 DATE Feb AESTR REFS.1 Bull . Hyg wee ne _ VOL PP 953 DATE Nov. 22 | . Italian Ed 1953 28 | amet ems The author has investigated cases of warts on the hands of 29 workers with lagging materials including asbestos cord which is wound around pipes PITSBURGH various containing slabs and mixtures of asbestos and cement to be molded to the shape of the tank or other object to be insulated One to four warts were found in every case They are due to asbestos fibers which INST UE penetrate into the epidermis and become lodged in the corium or true skin The epidermis shows acanthosis thickening of the prickle layer and hyperkeratosis increased horny tissue and the corium shows a granulo- matous type of reaction with the appearance of giant cells in some cases Mel on Exudative dermatitis may also be present This condition is attributed to the combined action of the hygroscopic and alkaline cement and the irritating asbestos fibers The gross and microscopic appearances of the lesions are illustrated -- Cond from Bull Hyg DATE EXAMINED BY: PURPOSE . OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONT'D . i CLASSIFIED SUBJECT 550 = Fe em do, SUBJgEiCT AUTHORI A. S. . Ramaswamy Someones . te oe | AALtt ad TE D. S. Venkatesh and R. -s FELLOWSHIP NUMBER | nfc le he nfc nfc Swe Rama Rao FILE NUMBER 752 + te Te anet eketOeG TITLE Pa The nature of lesions caused by asbestos and mica in experimental pneumoconiosis in guinea pigs ORIG REFS. | YOL J. Indian Inst 35 1319-31 DATE Oct. Sci Sect | 153. 2. ees A : ABSTR REFS | Bull Hyg DATE yol FP. |. 129 172 | |Feb'54 pigs - Guinea were subjected to intratracheal injections of mica a ~ and PIT^,buron asbestos dusts Stress is laid on the development after long periods of lesions in other organs besides the lungs especially in the adrenal glands Mica dust was found to the asbestos dust lead to some degree of nodular formation in the lungs but set up diffuse fibrosis only These differences are por- trayed in a series of photomicrographs Mica induced hypertrophy of the ad- Instiue renal cortex with extensive foamy disintegration of the cortical cells asbestos induced lesser changes but small areas of necrosis in the were occasionally found zona fasciculata and zona reticulata In a theoretical discussion the authors attempt to draw a relation between the atomic structure of mica and MEL ON asbestos and the pathological lesions in the lungs and other organs Their the~ ory however leaves many points unexplained from Bull Hyg { I, DATE . se . PURPOSE . - DE SEARCSH EARCH ABSTRACT BLANK FOR GENERAL USE - CONT'D eee os, - CLASSIFIED SUBJECT . . 8-54 9051 us : | oe FELLOWSHIP FILE NUMBER pola 752 e fibers TITLE The presence of asbestos in urine of workers exposed to asbestos ; P hazard : ~ me aa an VOL PP.a . DATE REPS ABSTR arr VOL OP... a DATE_ Rass med ind | | | | Italian _ 22 55-56 1953 .. Biol Absts _ | 28 1580 July'54 PITSBURGH ASSTRATL on In urinary sediment of two asbestos workers asbestos fibers were seen the same finding was detected in urine of two female patients suffering from as- bestosis who had left their work seven years before -- Biol Absts o- . mee se 1 Us- stitnge- ey erp es . INSTUE gem poem mer mes - a ee arr er s Dre mm ee ceme eee -- arc oe - . Melon - ce meee mee aa : re a ce ary we S ee 1 + FTE me cence tee sy weep oe momm ee wae - cme - . - wee DATE LEAMIMED:. RYs. . i wees toe + tm me ae ee PURPOSE OSFEARCHI ABSTRACT BLANK FOR GENERAL USE vee a . CONT Dene e ern aa = et ee i to" Experimental studies in metalcancerigenesis 6. Tissue reactions in rats Andrabbits after parenteral introduction 113-129 1954 | Chem Absts 48 23043 Experimental Studies in Metal Cancerigenesis 6. Tissue Reactions in Rats and Rabbits after Parenteral Introduction of Suspensions Arsenic Beryllium or Asbestos in Lanolin W. C. Hueper . Natl J. = 4 Inst 15113-129 1954 Cancer When powdered arsenic beryllium or asbestos in lanolin was paranasal injected into the marrow cavity of the femur pleural cavity or sinuses of rats there was no development of any significant number of cancers either at the site of deposition or remotely causally related to . the chemicals introduced Similar negative results were obtained with ~- . lanolin alone The sarcoma attack rate at the site of the injection for the _ (7 250 rats used stands at 0.8 contrasting sharply with that of 30 for Og 8 rats injected with nickel suspensions and 20 for rats given parenteral . 24 oh | EXAMINE ; aM OF SEARCHI - ; LISTRACT BLANK FOR GENERAL USE over ( over ) ee oo oe A ER TY AR I EE SMES FIER TET SR cage coy nts CR TOE CLASSIFIED SUBJECT * FELLOWSHIP NUMBER FILE NUMBER 1599 12/54 ETE Me 7 1599 a os 1599 12/54 ae at oa AUTHORI J. Krausler and R. Seyss ei, we SEE ERAS TITLE Early diagnosis of asbestosis by enlarged radiographs PA PA RGH ORIG RES ^ German__ VOL ve. DATE . . ASSTR REFS VOL ; - ee DATE rgh 2. Unfallmed u ' || Berufskrankh = 59-64 | Mar15'54 47 Mar15'54 Bull Hyg woe eee ee ee 29 | 829 | 8/54 _- > After a brief description of asbestosis and the changes in the lung tissue in the early stages the authors describe a radiographic technique with a fine ~ focus Of 16 asbestos workers with 1 to 18 year's exposure eight showed changes in the lung tissue with the enlargement technique two of these showed change by normal technique minimal and in the other six cases the degree of change shown was -- Cond from Bull Hyg ^ N~fi hy NOTI"W NOTI"W NOTI"W cw cee wets - we ee wee a me me ee eee ek mee ce cece - - - ~ - vee - ~ ag, 77 FORM DATE EXAMINED teas we ome ere an = PURPOSE Bvr OF SEARCH ABSTRACY BLANK FOK TERERAL UST ~ 5 CLASSIFIED SUBJECT o_o FELLOWSHIP | NUMBER NUMBER FILE NUMBER AUTHORI J. F. Knox and J. Beattie . - - TITLEI Mineral content of the lungs after exposure to asbestos dust PA , ORIG REFS ^buron | Arch IndHyg & ^buron Occ Med * VOL 10 || oP. DATE 23-29 ( July'540 July'540 ABSTR REFS VOL er DATE || | | _ ABSTRACT ^ buron ^ buro|n aoe Loe Lee, Loo. . . ve cee 2 enanjtih tine .. oe . mo The mineral content of the lung parenchyma the lung hilar region and the tissues of the pleural and subpleural regioinnsdustry lungs from 27 workers in the asbestos of the lung has been determined in The exposure time varied from five to 33 years and the time interval between the last exposure to dust and death survival time was from less than one year to 21 years There was an indica- tion that the mineral material found in the lungs increased in amount as the exposure time lengthened The amount so accumulated varied considerably from person to person As the survival time increased the mineral content of the lung tended to decline but again at a very variable rate The severity of the asbestotic lesions _ in the lungs found at death was related not to the mineral content but to the sum of the exposure and survival times om -- Authors summary 17 FORN DATE EXAMINER EXAMINER EXAMINER EXAMINER : ow . BY. wee wpe : . PURPOSE 92 SEARCH ABSTRACT BLANK FOR GENERAL USE CLASSIFIED SUBJECT - | FELLOWSHIP | | | NUMBER FILE NUMBER aad . Pa , sburgh AUTHORI J. F. Knox and J. Beattie after exposure to and fibers in the lung Distribution of mineral particles TITLEI asbestos dust ABSTR REFS VOL P DATE VOL 30-36 DATE ORIG REFS Arch Ind Hyg & 10 30-36 July'54 | | ee; ee . Occ Med . , ; . . insoluble a , sburgh ABSTRACT to in the incombustible and insoluble sburgh residues distributions The particle been exposed to asbestos dust were who had the lungs of 27 persons in excess of 26 microns residues from number of particles with greatest lengths asbestos dust and determined The to after the last exposure ( was considerable up to the eighth year of five microns within the size ranges The number of particles over a very long period then sharply fell remained constant and less and between five and 15 microns The minimal fibrotic change of asbestosis or of such particles < in those cases which showed no sign rise in the numbers severe asbestosis showed a significant with the production ere cases of severe the mechanism which is concerned of It is considered that which is responsible for the production LL asbestosis is not the same as that concentrations of asbes- of human animals exposed to high of experimental asbestotic changes in to be related to the breakdown of such changes seems ~ yr tos dust The appearance liberate some fibrogenic agent ~ y asbestosis bodies which may -- Authors summary 77 . : FORM FORM - MAIL | EXAMINED re ov ey: PURFUes OF SEARCH ABSTRACT BLANK FOR GENERAL USE ee CLASSIFIED CLASSIFIED SUBJECT H FELLOWSHIP FEL OWSHIP FILE NUMBER 855 | AUTHORI TITLE F. Leicher in a case of asbestosis cortical cortical tumor of the peritoneum Primary DATE VOL PP DATE ABSTR REPS _ - P^ ORIG REFE German Gewerbepathol Arch Gewerbepathol 131 ~ te PitsIbnusrMtgielueon Gewerbehy 382f-ol3lo9wi2ng long penetration of asbestosis long exposure to asbestos Gewerbehy zase and findings leptomenin- described In addition to typical symptoms fluid and tubercle tubercle bacilli were found in the spinal gitis was present showed tuberculosis of the The patient died with cachexia Autopsy in both with bilateral psoas abscess abscess and mixed infection | lumbar Aspsibneestosis stage two was found in the lungs with definite fi- lungs asbestosis in the lymphatic glands and asbes- brosis there was slight of the mesen- bodies were found in the spleen On the peritoneum tos were thickened patches and tery and over the peritoneal cavity there hand and 1 cm in many small nodules a flat tumor half the size of a peritoneum on the under side of the dia- was attached to the peritoneum thickness The results of the examination of the tumor are fully describ- phragm was found in the tumor tissues by ray ed and illustrated Asbestos Asbestos cav- diffraction It is uncertain how the asbestos reached the peritoneal of 20 route was thought to be by direct NT O cee 77 itthey atshbeemsotosst fpirboebrasblferom the lung through the pleura and thence through FORM the diaphragm we cee yg came es Darecenen wn Sette Se OO : ~~ - ( br 77 FORM < CLASSIFIED SUBJECT | Lied Gio AUTHOR Queries and minor . notes | JAMA | FELLOWSHIP FILE NUMBER | NUMBER NNF FC C| NFC mmr 752 re en Sarr ES TITLE Asbestosis Pa ORIG REPS.1 VOL DATE ABSTR REPS VOL PP. DATE J Am Med Assn 156 | 1546 Dec.18'54 seer ee eet es i nme omee r S PITSBUR^n year old man -A year worked at covering pipe with asbestos insulation from 1940 to 1945. The question is the possibility that pulmonary fibrosis evident on roentgenograms in 1952 was due to asbestosis when the films had ' been normal in 1949. The answer is that the cause of the fibrosis must be sought among other sources than the 1940-45 occupation Little evidence INST UE exists of progression of asbestosis after cessation exposure to asbestos fibers Moreover exposure would have had to much more severe than in the man's occupation in order to produce asbestosis and it would have . MELON manifested itself in the 1949 roentgenogram DATE EXAMINED a wy " * PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONT'D oe - - CLASSIFIED SUBJECT 3/3 3/3 , | FELLOWSHIP ' FILE NUMER ee NFC ee ee -_=-. AUTHOR = G. Jacob and H. Bohlig ie reas Incidence and characteristics of lung cancer in asbestos workers PA | ORIG REFGSewGeerrbmeapnath VOL | Hyg 30 12/55 Arch _ ASSTR REFS 10-28 1955 1955 VOL ve DATE Gewerbehve 14 Bull This is a study of the incidence of lung cancer among asbestos workers in Dresden . The international literature is based exclusively on the results of autopsies the incidence PITSBURgu neh| among asbestos workers appears to vary between 12 and 17 In Dresden however from , research into cases at the clinic and among asbestos workers it appears to be rare it be- ing estimated that only about one fourth of these workers have an effective exposure to the a sah dust In cooperation with the radiological and radium institutes the authors reviewed the cases of asbestosis reported since the middle of the 1930s These numbered 339 in all males stages they are classified according to stage and sex . Silicosis was found in eight INST UE 7 In five females and tenimales 4.4 of the total active open tuberculosis was found Four - fatal cases of lung cancer in asbestos workers which occurred in Dresden up to 1954 are : described A long discussion of the literature on cancer among asbestos workers includes an examination of the characteristics of the disease these are no longer convincing evidence of a high incidence of cancer in asbestosis In the future cases of cancer of the lung in Mel on # asbestosis should not be published individually but should always be considered in the frame- work of the whole asbestos industry in the region -- Cond from Bull Hyg eam emesee-: _ - a pees : am ww _ ee ied RE | ood a eeee r er Py &s cetanerantiaeammm eeod + beeen oe re Sry EXAMINED . aw eo OF SEARCH ABSTRACT BLANK FOR GENERAL USE ~ . CLASSIFIED SUBJECT ee 90 urmoe, 1/56 R. S. | TF Speirs ea eee a nae eg TW @ covN atal and U. Wenck .. ee FELLOWSHP oe ee. NUMBER - PA inflammatory - Local bestos type filters response produced by solutions sterilized with as- ORIG REFE.J se Biol | | Med 89-93 DATE ABSTR 88 Proc Soc Exptl | APPS - 1, OL ee, DATE Pitsburgh Jan'55 | | ! It was 9/55 experiments Biol Absts demonstrated that 29 2142 cellular respouses of the filtering through an asbestos type filter disc will which have organism to that solution pulled off the disc and are present in the This change the local reaction is due to particles and fibers eosinophilia appeared following injections filtrate at the time of injection A similar paper fibers Ground glass and of asbestos and talc but not following silica phils It was pointed out mica produced that precautions only slight increases in the number cotton of local or should be taken to avoid eosino- | accidental introduction of asbes- INSTIUTE to demonstrate that a study of the local cellular better understanding of the effects of a solution responses to an injected material can lead upon an organism - Biol Absts Ve wn MELON - 1 EXASUNER PURPOSE SEARCHL . ABSTRACT BLANK FOR GENERAL USE CLASSIFIED SUBJECT 572 55 FELLOWSHIP | FILE NUMBER | NUMBER wt FC 752 752 TITLE Functional abnormalities of industrial pulmonary fibrosis PA ORIG REPS US, ... Burgh Arch Otc Health VOL PP. / DATE . ABSTR REFS , ; | VOL 5 s wwe DATE | 11 183-211 Mar. 155 | | | Burgh Functional of Abnormalities Industrial Pulmonary Fibrosis Wright G. The author describes the function of W. and respiratory cardiocirculatory apparatus in a simplified form for the benefit of methods of quantitating some of the lay persons and discusses the circulatory systems He physiologic aspects of the respiratory and in its shows how the results of these methods indicate various stages The typical appearances and clinical silicosis tosis are then described and conditions in asbes- . there is contrasted with those in silicosis a gross correlation between intensity and duration of As silicosis exposure but no terminal two diseases but in the and stage the distinction may may lead to confusion A further coexistence of the diseases difficulty in diagnosis is the frequent Both may be roentgenologically manifest without recognizable physical impairment , DATE EXAMINED Ax. PURPOSE Sg , ABSTRACT BLANK FOR GENERAL USE . CONT'D i Pra ef pant . Soe eemome 6 ae ea FELLOWSHIP FELLe OWSHIP eae oe, STR FEL OWSHIP FELLOWSHIP FELLOWSHIP iNUMBER NUMBER | NUMBC NUMBC ae eee uwac: 752 | autnor, P, 155 ss . | AUTHORI | By , P. clinteai observations of asbestosis mine and GRIG. PA RCrs.: we PA . . cet wee, Cf GRIG RET Heals a urgh _ a OR a LPP. . YOL YOL t 183-211 DATE . DATE AGSTP ATFS . Mar. 155 meme a mill : workers workers : . vou. f | ry 5 : Q rs discrepancy Some Clinical Observations of ~ Some Clinical Asbestosis Mine Mine Mill Workers Statistics P. Workers Statistics comments are presented on 128 observed Statistics and coments comments of eight cases asbestosis asbestosis asbestosis of author importance have years In his experience been diagnosed by the asbestosis without without previous previous clinical clinical importance roentgenologist The wide pathologist appreciation appreciation detection detection asbestosis by different confusion confusion especially before @ compensation board The pathologists leads to obvious before a compensation limitations of the table employees shows that status status of cases is good and that employees early early stages of asbestosis asbestosis able able work % employees remaining remaining t good correlation without discomfort clinical clinical cases no of between degree of asbestosis and status been found no clinical status bas been ee found. ay 12 fOnMm DATE EXAMINED . AY { . eee we oe SEARCH ABSTRACT ABSTRACT . CONT*O. GENERAL et ae, Austnacr BLANK FoR SP een oo SGEneraL use oe eee oo me 5 aceteee ns mee, oe EN eee. ee ees PP. DATE Mar.155 , Cee Asbestosis as Differentiated from Other Pneumoconioses F ; Ing which not only are embarrassing which may cause irreversible irreversible harm to embarrassing to the physician but | be thoroughly investigatedinvestigated that the patient Every obscure case should so such unfortunate situations do not arise oo Melon DATE , PURPOSE ABSTRACT BLANK FOR GENERAL USE CONT D.cemremens CLASSIFIED SUBJECT f FELLOWSHIP NUMBER FILE NUMBER 1185 9/56 185 185 9/56 rr ee a} eo = PS. a on + ae ee Stet le more wo Fea. _ Cte 7 | NFC . AUTHORI Pa pulmonary TITLE H. Bastenier H. Denolin A. de Coster and M. Englent A study of respiration in asbestosis 752 Arch maladies 16 546-5531955 . profess ~ . 1955 Bull Hyg 544 5/56 INSPTiIrtsUbTuEgh value 31 | | Breathing breathing functional In order to test the IITs EL Lome were closely studied The respiratory value of lungs affected with asbestosis 1,000 to 2,000 2,000 seven men and two women had been exposed to nine cases particles per cu m , for 18 to 30 asbestos dust symptoms of asbestosis with troublesome years The patients displayed definite like ground glass cough and dyspnea and all showed extending over both lungs No tubercle bacilli ray shadows definite reduction was found in vital were found in any case A factory capacity but the maximum however was accelerated by hyperventilatieoxnpirAattory volume was satis- sufficient and satisfactory hut on exertion dyspnea rest was ing to the pathological lesions in the lungs These appeared varying considerably accord- ent from those seen in other changes were in no Varying , no special strain cases of pneumoconiosis was thrown upon the heart way differ- emphysema was found but Melon -- Coad from Bull Hyg EXAMINED EXAMINED ay, FFR PUPPOSE SEARCHI . ABSTRACT BLANK FOR GENERAL USE . CONT'D . ( Li < # . ne ee CLASSIFIED SUBJECT . 1572 . Ses FELLOWSHIP . NUMBER a ae ete ST - ee wt' at entation Mme Te . wee ew Te FC FILE NUMBER 752 A. J. Lanza AUTHORI ' . TITLE Recent trends in industrial health PA . 11 183-211 Mar. PA , ORIG REFS . aoe a Uran Arch Occ Health VOL . PP Mar. DATE '55 HEFS oe ee Recent Trends in Industrial Health A. J. Lanza This short address serves as an introduction to the sizes the need of continued progress in the study of scientific papers dust diseases and DATE empha- INSTITUTE INSTITUTE INSTITUTE INSTITUTE INSTITUTE INSTITUTE INSTITUTE Mellon Mellon Mellon | Mellon Mellon Mellon of > 2 DATE EXAMINED | TL ee , PURPOSE SEARCH_ ae OFABSTRACT BLANK FOR GENERAL USE CONT'D 28 a ; . | Se me tte ete FR ek ee ee FELLOWSHIP | FILE NUMBER Lanza Lynch AUTHOR Arch Health Wright Cartier TITLE Bristol . Pa Symposium on occupational diseases of the lungs ORIG REFS : + 11183-211 Arch Occ Health 11183-211 VOL 1 183-21 11183-211 11183-211 DATE 11183-211 Mar. 155 AGSTR REFS ste ee rou | 183-21 Ind | Symposium on Occupational Diseases of 183-211 Mar. 1955 the Lungs Arch VOL Ind Health a 11 . DATE Massachusetts Diseases of the Lungs sponsored by the tion with the Institute of Industrial Medicine ate Medical School Boston Oct. 28 1953. Medical Society in coopera- of New York University at Gradu- Asbestosis is the main theme of the 3 a DATE _EXAMINED RY PURPOSE ABSTRACT SLANK FOR GENERAL USE CONT'D CONT'D 372 | 372 372 ! i AUTHOR sst st sst' sst sst st L. J. Bristol | FELLOWSHIP i NUMBER | Tz FFC C Yoon FILE NUmme 752752 Pa | TITLE Roentgenologic aspects of silicosis and asbestosis Pa : , RIG REFS | VOL - DATE ABSTR REPS VOL PP. 11 11 | | Roentgenologic Arch Gec Health | 183-211 Mar.155 Mar.155 Jurgit 183-2 Silicosis | a Aspects of Silicosis and Asbestosis L. J. Bristol Tthyepitcharleeroentgenograms show the appearance of silicosis and of asbestosis in stages of each and of silicosia tuberculosis The functional ment in silicosis is due to diffuse obstructive impair- in full expiration aids in emphysema and ray examination evaluating the presence or absence of this On the other hand not all cases of asbestosis have complication films are not of much value in a breathing problem Expiratio determining the presence or absence of impairment in these cases Some respiratory asbestosis show persons with slight ray changes indicating definite functional impairment This situation does not occur in silicosis , jz jz cz DATE -- -- ---- - EXAMINED |! BYi tee. PURPOSE . OF SCARCHI ABSTRACT BLANK FOR Tt men te mem GENTRAL UST em CONT'D ee eee A, \ . ae . - - aof 77 FOum | | 11/3 i a| R, 4/55 tee oe | < NUMBER NUMOCR NUMOocR | AUTHOR a Doil from lung cancer asbestos asbestos workers UP OMe ners, ~ rh Pa ORIG REF3.1 Ind, pA Med. -,, DATE 81-86 REFS.1 REFS.1 7 Apr. 155 Apr. Med yt 81-86 2 AsaTRACT.; a ee | | A oe - . vot eee oa oe ee: E Workers 1113 Mortality from Lung Cancer Pittsburgh Mortality Mortality in Asbestos Workers INSTIUTE & from 12 81-86 Apr. 1955 Doll Doll J. J. c Sy a INSTIUTE = Z IINSNTSITUTEUE Q MELON a MELON fe rx MELON | t Date asbestosi'works In necropsies of 105 : persons who had been lung cancer was found found in instances instances employed cases cases asbestosi'works was also found in 15 instances These 15 workers - employed at least asbestosis nine years before 1923 when dust regulations become effec- effec- nine years additional 1131923 men who hacdonbtereonl regulations regulations asbestos dust mortality was tive tive years were followed up and their compared with for that the whole male population population mortality deaths occurred with Thirty that group whereas 15.4 were expected excess excess entirely entirely due The 0.8 to excess deaths from lung cancer 11 expected and from against 0.8 - , " expected) and CONT'D DATE av; PURPOSE OF CEARCH PONT DN AESTRACT BLANK FOR Guiveway VaR ne aner, Digest other other other respiratory and All the cases of associated with associated with lung cancer asbestosis asbestosis asbestosis were gonfirmed From From data data From data it histologically concluded and that all were workers has the average of the order population The risk has duration of employment under the from author's summary if | Fee 1 en ree es eee te i, A eee kee sem eee 1 ' wegen . oe eee ! i $ i ! + : j : V 1 t : ij t 1 t i on ee ln : . | i ! ! 4 bam ee gue oe co memes oe : ; ! H j t . i i : ' Hi H , tine et ets ms ee Meena ees e: : : ' . t : ! H : : 4 : TS : i , 1 em ee metas 8 . eae mae \ | > { | oe ae sates sep mes coe be me wee ee ne 2 ee _ om ete we meee eens MO Anew mee tee ; _ ad Pulmonary d isabilityinasbestosworkers PA rm oe a oe eee VOL DATE ACSTH aers., Health 12198-203 155 - Respiratory Coes disease experience among several thousand male-.: reported and female asbestos workers in the United States andCanadais PirinurghOf all workers exposed to the fibers very few develop asbestosis This =. insidious exposure disease is in onset and progresses slowly with continued 7_ _ . causing respiratory embarrassment and cardiac failure Expansion of the - Institute lung is difficult and theries impaired gas transfer through the lung Dif- on iL fuse obstructive emphysema is isnot common The typical aes oem ray pattern ae pneumoconioses An ray survey cannobte confused with other of 708 employees in a milling operation showed that the majority had Fe Re Mellon to that no neosrsmaalry Ps . found and found raypatterns that ten or more years of exposure were nec- produce ray changes and cases of asbestosis were a who had worked less than 20 years in the dust The incidence duration of nonoccupational respiratory disease were not increased by | exposure Asbestos does not predispose to tuberculosis nor does it a/ aggravate an apparently healed lesion There are several reasons for . 4 differdiffeerennt topinions - expressed conceconcerrningniconcnernging e tehe asbestosis relationship of asbestosis _ ee _ ae ane . aia 2S Re Set nae yeinetE ne se eit a : : s - : . ~ _ t . a aot a ol, : . 4 . t ~*~ { 4 . oF ate , t nee ie : ' | to . : elm mens t cee nh iz eee { ey wogh a a ' 7 i ce atin wo t eet a + mm vee ce Fos - + - . . ee) 3 3 + a } an . ~ ee : ele, : Pores ; cre ee Sar . . a ao oon - + 6 Sr : . . wee : . ewe we . + tes re are Pen tome . be ~~ 1 eee a ee cee a ree as -ee me de . i,os . fl ; , we: + ade al : oe i + 4 . . a : , . og - . 4 : ; - comaeen H ho ee | oo t-> pa re toms we ale eee }. : f M . as .4 ! : Se Steee z . ? { ' . 17 fet es "yw aoe 4 eseataienens kintte Seaton a pedo . . 5 { . |: a eens me. te eee -3 : . : aes : rf oye wad chee eo {3: +t a - a i i Hanne gece. 2 to 2! _d --- cee ee , j + | : . bee : . - wee 4 3 : 7- * . - : ; Poe . rar : [~ r 7 ; . . ow ee : a vo: : a + ae 4 - CLASSIFIED SUBJECT SUBJECT 1011 3/57 3/57 3/57 |; NUMBER NFC weuswe $ | AUTHORI M. Navratil V. Krecek and L. Cvachova 752 TITLE Results of functional respiratory and circulatory tests of workers exposed to asbestos dust over a number of years PA ORIG REPS Czech Czech VOL 8 Pracovni Lekarstvi | 329-333 ns Bull 32 460 | ABSTRACT oe o DATE .- | 1956 A - ACSTR REFS.1 Hyg a ae VOL PP ne DATE DATE 5/57 eee soe , dust dust Sixty workers exposed to asbestos dust were classified according to eee severity of PitsBURGH asbestosis and according to age They were subjected to functional tests for expiration and for ventilatory coefficients and to prolonged electrocardiography In the over 50 age group quite apart from all radiological data a drop in vital capacity is found due not merely to age but also to emphysema which was detected in 19 patients coefficients in the asbestosis and The ventilation early asbestosis groups were within normal limits In those with advanced asbestosis there was a distinct drop in the ventilation due to fibrosis and associated coefficients INST UE pathological conditions The differences in the carbon dioxide ventilation coefficients and in the vital capacity figures were on the limit of signifi- 6, cance Hypertrophy of the right heart was present in two subjects with advanced asbestosis asbestosis 1 10M Melon . -- Coad from Bull Hyg . 7 77 FORM DATE -. EXAMINED_ RY. FFR PURPOSE OF FARSHL FARSHL ABSTRACT BLANK FOR GENERAL USE 4 . CLASSIFIC SUBJECT ~* 190 9/20 190 190 i ES oieoe 9/20 CNIS SSPE = FG SL, == woe COS ce AUTHOR H. Bohlig and G. Jacob 7 FELLOWSHIP | NUMBER FILE NUMBER | NFC MY ne 7 753 753 . : Pa Pitsburgi INSTIUTE Melon TITLEI New viewpoints on pulmonary cancer in asbestos workers * Deut Wochschr 81 ORIG REFS German German . VOL med 3 s- UCT See SSS eens - a _ DATE . AUSTR RIFS .. Feb. 156. 231 233 Ptr 17 J. Am eee TSS epee VOL PP . Med Assn 916 ae DATE 16/30/56 The following distinguishing features have been has been recognized as an attributed to the lung cancer that dence 2 development occupational disease of asbestos workers 1 increased inci- at an early age 3 dependence on duration of dust 4 a latent period between onset of exposure to asbestos the localization 6 the histological exposure structure and and the appearance of the cancer 5 7 the multicentral origin The authors discuss each of these points and show that there is little clear these assumptions with exceptions noted evidence to support any of Women workers in the asbestos industry have lung cancer more often and at an earlier age than do other women but the true of men Malignant growths of the pleura seem to same is not than in other persons The multicentral occur more often in asbestos workers to cobalt and to chromates The development is observed also in workers exposed and the study of the pathogenesis is still in the state of theory of mechanical pathogenesis is given most hypotheses asbestos bodies are always found in the consideration Microtraumas and authors feel that this does not pulmonary cancers of asbestos workers but the factors that necessarily prove the mechanical theory They cite several speak against a purely mechanical pathogenesis of asbestos concede that the development of called asbestos cancer but they asbestos on human tissues warts proves the irritating effect of -- Cond from J. Am Med Assa . t DATE . EXAMINEDI EXAMINEDI | gv, FFR PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE . CONTD . , i a oe. s ot 8.89 10M te ee ee ee ee ee FELLOWSHIP FELLOWSHIP FELLOWSHIP 9/56. FC 1189 AUTHOREI. R. Wiese and W. E. B. Hall FILE NUMBER 752 TITLE Asbestosis report of a case Pa ORIG REFS Diseases ofChest VOL 229,230 DATE Aug. ABSTR REFS VOL PP, 30 229,230 156 | | fatal The history and autopsy findings in a case of asbestosis are reported Conditions described include absence of the middle lobe of the right lung greatly en- PI^fltsburgh larged heart wide spread sharply demarcated development of fibrosis and degenera- tion of collagen in extensive irregular fields These and other conditions are described fully Fine needles representing the original asbestos fibers were seen Smail asbestos bodies were seen in a few areas of focal fibrosis although they had not appeared in the INSTUE sputum Melon 77 FORM DATE EXAMINED EXAMINED BY FFR PURPOSE OF SEARCH ABSTRACT BLANK FOR GENERAL USE CONTO ee Lf fOke, SOSt, Frost wane ILE ~ = PA Mod . ' wall, ie i Georg fad Bs Georg and SUE 2 an Meller Meller ar, among insulation workers 3 : 26.4... Dari DATE Bull Nov. ! t 179 Reng Hyg Hyg, WORE ry OL. 122 i ee, 260 3/'- : i! mop i, ibrogenic clinically surpris- lungs : it abnormalities adhesions some were thicken- = ; DEN i finding kieselguhr not ascribed toy analyses definitely changes i , age Tish kieselguhr kieselguhr [ kieselguhr the dust inhaled inhaled ascertain occupational occupational ing risk work workers carefully carefully their more years exposure exposure ascertain years average than years Abnormalities of years in = ag In yy Abnormalities { number examined examined clinically mine and by fine Abnormalities pulmonary pulmonary the to COM MELEGEN MELEGEN to : combined Sample of iF changes exhibited fine were seen mottling indicative pulmonary indicative and asbestosis thicken- extensive extensive calcification which pleura were widespread thicken- instances other pathological in The calcification so unusual unusual obliterate exposure calcium magnesium magnesium presence of fibrogenic rady asbestos dust combined exposure exposure and use did the presence fibrogenic asbestos . reveal presence of . The ines bilateral kieselguhr pleural changes changes reveal prescut series definitely alpha quartz points an "ce pronounced pleural the prescut Bull Shanzes in the Cord from PTesent from Hyg duse, Hyg gs Series The SBT Cetinitel, ' ' : Late -- Cong, POicts ig an feory Bul. Hyp, fog Rabiner Fe See me f Gy, ~ i775 ~~. ABSTRACT SI Lae, ABSTRACHE Mansy Far SENZA A, ure COND. CLASSIFIED SUBJECT t : FELLOWSHIP NUMBER se ee ee FILE NUMBER AUTHOR M. Lynch F. A. McIver and J. R. Cain TITLE PA Pulmonary tumors in mice exposed to asbestos dust ORIC REPS VOL ABSTR REFS Arch Ind Health 15207214 Mar A ee ee ee Pr. em eee To tmeeee VOL mmeemmee ne DATE - -- - DATE DATE | 15207214 15207214 571 a ABSTRACT , Oot RS ee em ee a. Mice of a selected strain AC F were exposed to a dusty atmosphere PITSBURGH containing -~ asbestos floats of a type used by others experimentally at 150 to 500 million cubic foot The largest single experimental particles per group consisted of 127 animals killed at 19 months after exposure for 17 months This group was compared with 222 222 control animals were demonstrated Primary lung tumors microscopically in 46 of the mice and in ( dusted 36 of the controls Multiple pulmonary tumors were demonstrated in 18 of the dusted animals and in % of the control animals No significant histologic or cytologic difference InsTI UTE was observed between tumors in the two groups No clear proof of found in any of the lung tumors studied malignancy was The authors have been unable to demonstrate proof of the carcinogenicity of asbestos under the conditions of the any experiment but the increased incidence of multiple lung tumors in dusted animals must be ble accentuation by the inhalation of asbestos dust of regarded as a possi- Mel on an existing tendency to develop lung tumors Future experiments with asbestos should include the use of larger animals prob- ably monkeys The equivocal nature of this report does not answer the questions raised by accumulating clitical evidence that asbestosis is strongly associated with and therefore is a possible cause of pulmonary carcinoma in man -- Adapted from authors summary DATE EXAMINED _ = snes BY - i Ve meee FFR . PURPOSE PURPOSE Aer ce a OF SEARCHI a ABSTRACT BLANK FOR GENERAL USE oe CONTO CLASSIFIED SUBJECT 219 2/55 | AUTHOR TITLE E. Sartorelli Severe asbestosis with capillary block syndrome PA ORIG Ds Italian Med lavoro . VOL + DATE ABSTR REFS 48 358-362 | 1957 ane nme Bull Hyg so ae tee + een eee mente on VOL 969 DATE be | 969 pct author reports ABSTRACT The _- aged in a case of severe asbestosis a man 57 who was em- ployed for seven years in a very dusty asbestos factory Three years after commencing PITSBURGh work the patient complained of dyspnea on exercise with slight sputum the condition be- came progressively worse and finally be was sent to a sanatorium as a case of combined tuberculosis and asbestosis with a disability of 50 After two years in spite of his res- he started work as a general laborer and was admitted to the author's piratory symptoms clinic three years later with a recurrence of chest symptoms No tubercle bacilli were found ray of the chest showed intense reticulation especially in the medio regions INST UE small zones of fibrosis in the right clavicular area and thickening of the pleura at the left base Tests of respiratory function showed dyspnea on repose and markedly so on ex- MEL ON the ercise and while respirometry gave only slight alteration from normal the oxygen satur ation was only 90 The diagnosis of advanced asbestosis was made on account of marked respiratory insufficiency absence of tuberculosis increased erythrocyte sedimentation rate -- Cond from Bull Hyg and hypergammaglobulinemia DATE _ EXAMINED : ay: CONT'D ee ; PURPOSE JM OF SEARCH Oe REACT cme ABSTRACT BLANK FOR io ne ee ee GENERAL USE . ne en eens en meiwn ees meee meme