Document ZJLkD19N5jyY1nJJBm7p4m2EJ

Wildlife International. Ltd. - 1- Project Number 454C-107 DETERMINATION OF THE WATER SOLUBILITY OF PFOS BY THE SHAKE FLASK METHOD ADDENDUM WILDLIFE INTERNATIONAL, LTD. PROJECT NUMBER: 454C-107 3M LAB REQUEST NO. U2723 OECD Guideline for the Testing o f Chemicals, 105 Water Solubility This study was originally reported using a test substance purity of 98.9%. The test substance characterization was revised on 9/7/00 and the purity was determined to be 86.9%. The Sponsor requested that the results be revised based on the most recent purity analyses. The measured concentrations originally reported were simply corrected by the ratio of the two purities, or a factor of 0.8787. No attempt was made to recalculate analytical standard concentrations. As such, minor errors due to rounding may be present. Attached is die revised summary page from the final report and the most recent certificate o f analysis. Wildlife International. Ltd. 2- - Project Number 454C-107 REVISED STUDY SUMMARY BASED ON A PURITY OF 86.9% STUDY TITLE: WILDLIFE INTERNATIONAL LTD. PROJECT NUMBER: SPONSOR: TESTING FACILITY: LOCATION OF STUDY, RAW DATAAND A COPY OF THE FINAL REPORT: Determination o f the Water Solubility o f PFOS by the Shake Flask Method 454C-107 3M Corporation Wildlife International Ltd. Easton, Maryland 21601 Wildlife International Ltd. Easton, Maryland 21601 TEST SUBSTANCE: TEST DATES: PFOS Experimental Start - February 11, 1999 Experimental Termination - February 20, 1999 TEST SYSTEM: NANOpure Water SUMMARY: The overall mean solubility concentration of PFOS in NANOpure water was 498 mg a.i./L (SD = 46.4; CV = 9.32%; N = 6). Wildlife International, Ltd. -3- Project Number 454C-107 CERTIFICATE OF ANALYSIS INTERIM CERTIFICATE OFANALYSIS Centre Analytica3lMLaPRbRreooefdrevaruitsecoinotr;cineePs#1F:(C9OO/S7DSA/0,-0L0R)1oe8tf2e1re7nce #: 023-018A Purity1Test _____________________ Name - PuritSyp;eI*c*8i'f6i.c9aVtion_*s______________'______ 8R6e.s9u%lt AIMTT(T(RPRPIOEdLGnopOooueeeleCroeCtpnttlrsgtAaraaamai234i56/e7t12ag43/t56724234dl13Mtlli151lM..Aay.....efnsa.e.......u...%.%..%..irdninbcSaa(cSNCaISMtiPNnMIylCF)NNCTPBNIISacPNCHHCSI)FrAtcomommSaioMllihoFFDuhruAaloaiiaePFucyFditluooncAttotmgcapllnplPprkAnrridor/PBSRonffomlibuisMsnaioguueuvnAiurdruptArCisrptmoAteolgieaorrrieaiiermiesodhdidsiinSnugnennlt"tt'uieyaeeyyyenmee)utsn(stsnsmIe((di2eC(sINsTC'):M-G) AR)) " *"W4.h<Tite~.Cr<yxsVtal.linVePow<dfer Jv. * .. . *3v^< * *****<i- V ^ < v' "S? > 2 +W 'V A. " ^ s.~~*f ' f'I>V*?rK**' ' ^ ~! : - . r ...... i-Jsf'-Vtft..?V.r^*-y* "[tr >., v .*!. .......'............. K M 1 T r l>-l, .1'* . ** * ** v>! . ' ` :? 'f j *- * * l * a* - *-\r 34251..... TTTTThhhhheeeeeooooorrrrreeeeetttttiiiiicccccaaaaalllllVVVVVaaaaallllluuuuueeeee=====00651%%.079%.58%% Conforms Positive 2346571.......81..4900<6<0113....0.000804ww..004030015tt95900//11wwwwwwwwwtttttt..t.A//%%//wwttww//vwwttttt...%%%%%tt..%% None Detected NN0o.o3tn3AewpDptel/itwceactbt%elde3 2345671....... 000000.8....00000..57140009650967wwwwwwwtt//tttttwwA.////wwwwtrt%%ttttt..%%%%% 2341.... 0000....211180 wwwwtttt////wwwwtttt.%%%% 23415..... 08151..24.287..4144484wwwwwttt///twtww//wwttt..%%%tt%% COA023-08A Page 1of3 Wildlife International, Ltd. -4- Project Number 454C-107 INTERIM CERTIFICATE OF ANALYSIS Centre Analytical Laboratories COA Reference #i 023-018A Date of Last Analysis: 08/31/00 Expiration Date: 08/31/01 Storage Conditions: Frozen <-10C Re-assessment Date: 08/31/01 F0'P.l3uu3ori%rtiyd)e=, 01.0509%%-+(NsuMmRoimf mpuetraitlieims,p1u.9ri3ti%es+, o1r.4g5a%nic+aLcCid/MimSpuimritpieusr,it0ie.3s,88%.4+1P%O+AInAo,rgamc ToPtuarliitmy p=ur1it0y0f%rom- 1a3l.l0t9e%sts==8163.9.0%9% JPotassium is expected in this salt form and is therefore not considered an impurity. PobusreirtvyebdyfDorStChisissgamenpelrea.lly not applicable to materials oflow purity. No endotherm was ^idonSenotuetrlhgrfmuearnriiinencsaautthinloteisno,sniatnhmmethpeSelteh0eoa4ldepimpsceoneannordtstaictltoioaonnnbsaseil.dycesToirsneh,vdeleeaarnnntdeiidiomnntgporcueSorsiOnutyfl*it.daaegnnrdceehesetonwcteehlildsweitniettchetretphdreeutssauitnlifogunrt.heBased 5THNPFFFFAPBPAAA HTPNeroeinpfnlttouaaffoflhlruuiooooarrrcoooeppbtreiuocotpylaaardnincdooaiiccdaaddddd `Theoretical value calculations based on the empirical formula, CsFnSOj"K+(MW--538) This work was conducted under EPA Good Laboratory Practice Standards (40 CFR 160). / COA023-018A Page 2 of 3 Wildlife International. Ltd. -5- Project Number 454C-107 INTERIM CERTIFICATE OFANALYSIS Centre Analytical Laboratories COA Reference #: 023-018A LC/MS Purity Profile: ImTpCCCCou4567trailty wU41181w.....73241L32214 % Ncfaruvooremtvreae:tgsh,eTerrheCesesp4Cpeoac4nntiadsvneeCdlfy6aC.cs6tTtoavrhnsaedlfuaCrore5dsmvwctuahelrureveeeCcsw.6alacalsiunkcdleaawtlCecd8uisluesat,tsaeitnndhdgeuatsCrhidne7gcCvuta4hrlvueaeenas.dwveCarsa6gcseatlarcenusdlpaaotredndsceuasfliiabncrgtaottrihosen Prepared B y : Reviewed By: _D_JSLo_caa__hivbe__nion_d_Frt__aiSls__tat.o__h,Br__Cey__eretM_l_yln__ta__rne__a__Ag__en__ra_,_ly_C_t__iec__na__tlr_eL___aA__b__no__ar__lay__ttoi_criaelsLaboratoriesDD____aa__ttee__1. COAD23-018A Page 3 of 3 ildlife International, Ltd. E C O T O X IC O L O G Y & A N A L Y T IC A L T E S T IN G SE R V IC E S November 27,2000 Ms. Susan A. Beach 3M Corporation Environmental Laboratory 935 Bush Avenue 3M Building 2-3E-09 P.O. Box 33331 St. Paul, Minnesota 55133 > Dear Susan: Enclosed please find Addendums for the following studies: 1. Non-GLP Study: Determination of the Solubility of PFOS in Wildlife ISnatletrwnaatteiornal, Ltd. Freshwater, Freshwater Algal Medium, and 3WmilLdalbifReeIqnuteesrtnNatoi.oUn2a7l2,3Ltd. Project No.: 454C-101-1 2. Determination of the Water Solubility of PFOS by the Shake Flask WM3meiltLdhalobifdReeIqnuteesrtnNatoi.oUn2a7l2,3Ltd. Project No.: 454C-107 If you have any questions, please let me know. REnLcVlo/csyuwre8s/3m Raymond L. Van Hoven, Ph.D. Scientist 8598 C om m erce D rive Easton, Maryland 21601 -Tel.410-822-8600 Fax 4 10-822-0632 E-mail ecotox@wildlifeintemational.com European Office: Bergkampweg I 7 2 3 1C L W am sveld The Netherlands Tel. 3 1(0) 575 - 573848 Fax 3 1(0) 575 - 5 7 4 8 13 E-mail; aleopold@worldonline.nl