Document ZJ7Drr74kdQKVmrmxGqD7O15J

TOXICITY Jr- PYPKAUL PU/IPS PYdmul f-9 There has boon considerable toxicity r*Mrh an Pydraul P-9. Attached la a discussion and interpretation of tha toxicity studios. The result* are also summarized in a briefer fashion on pa&e lb of th* enclosed Pydraul f-9 Technical isuiiotin, pydraul u25 The Oral UV30 of 3^.3 grama per kiiogram when teatod with rata, and the oral Minimal bethel Com of 5.25 to 5.00 grama per .xiloiiraa when tested with rabbit* indicate that Pydraul 025 nay bo olaaaod aa relatively harmless' to slightly toxic from the standpoint of oral infection. Potential irritation studies with rabbits show that It la only a mild Irritant to olein and eyes. In acuta vapor inhalation studies, rata survived a 0-hour exposure to atmospheros saturated with vapors of the product, me above figures are lower than thoee obtained in studies with Pydraul P-9. This ooraarlaon is significant since Pydraul P-9 has been used sinoe 1949 with no reports of skin irritation or other toxic effects. pydraul ISO The toxicity report on Pydraul 150 indicates that it la prac tically innocuous whan fad orally to rata since the animals survived single doees of 26.5 grama par kilogram with loaa of appetite and severe diarrhea aa the only toxle effects. The fluid apparently is not abeorbod through the unbroken skin of rabbits sinoe this species survived doses up to 9.5 gnus per kilogram of body weight. In rabbit akin and aye irritation studios, Pydraul 15 was no more Irritating than a 10 aoap solution toated similarly. Aa indicated with Pydraul F-9, how ever, Pydraul 150 will cause severe pain if there la accidental plashing in the eyaa of humans. Hata survived a 6-hour ex posure to an atmosphere saturated with Pydraul 150 vapors. *n&anL.kr&9i Our interpretation of th* toxicity data obtained on this newer oynthotie hydraulic fluid Is that accidental ingestion la not a particular hasard In view of the high oral lethal doe* (Oral UVni 10,500 eg/kg). similarly, single massive akin expoeureSahould not be lmadlately hazardous (3kln KLDi 625 to 1,250 ing/kg). The lethal doae following akin penetration ia such, however, that prolonged and repeated akin contact should be avoided. Such exposure must also be avoided to pre vent skin irritation, we also feel that vapor Inhalation should bo avoided when th* fluid la at elevated temperature*, sueh exposure again relates to prolonged or repeated exposures rather than massive or aeuta exposure. In the ease of the latter, workmen would probably not voluntarily subject thcmaelves to concentration* that are hazardous for short periods. HONS 071298 -2Pydraul AC In aniual toxlolty studios with Pydraui AC. the oral lethal dose in rots ! approxlmately 40 grams per kilogram and Tor rabbtto, 3-5 to 4.;> graraa per kilogram. The greater sensi tivity or rabbits la typical of this typo of fluid. This lethal doeo la of such an order, however, Wist tiie fluid nay ho considered only "slightly toxic" to man frees Uvo standpoint of aooldental ingestion of single oral dooea. The fluid nay bo ahaorhod through the unbroicen slcln of rabbits In doooa reBulling in death, but again the minimum lothal dose la auch tiiat aooldental naaalvo slcln exposures to tan do not present a hazard. Sltin and ays irritation studios with rabbits would claaeify the fluid as a olid irritant. Laboratory animals survived six-hour exposures to an ataosphsr* saturated with tha vapors of the fluid. On the basis of this data, it la ooneludad that fydraul AC requires no speelai handling pre cautions other than avoiding prolonged or repeated agin contact. Accidental splashing in tlie eyoa will result In moderately severe pain and irritation but no pemanont damage should result. *&NS 07U"