Document ZBp405B9jpdY8av0D3wv0zGyY
- EXHIBIT /
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July 18, 1975
Dr. J.C. Galandrs, Industrial 8X0-TEST Laboratories 1810 Frontage Id. ,, ,,
Horthbrook, 111. 6C0$2
re: ARCCLOR 2-year tot Feeding Studies
' Dear Jot i
e
Kit attached table summarises a comparison of the 3 revised AROCLOH reports (1242, 1254, 1250).
1
In 2 instances, the previous conclusion of "slightly tusorigenie" vis changed to "does not appear to be carcinogenic". The latter phrase is preferable, Kay m request that the AROCLOH 1254 report be aaended to say "does not appear to be carcinogenic*'.
f
l'
The number of hepatomas reported for AROCLORS i860 and 1242
have been interchanged. This appears to have arisen from con
fusion regarding the numbering of the animals. The original
reports show tumors in anlsals with numbers in the 100-300 ring#
for AROCLOH 1260 and in the 500 to 800 range for AROCLOH 1242.
This leads me to conclude that tha nuabering scheat shown in the
second set of reports la correct. With AROCLOH 1254 confusion
is conpounded. The original report showed turners in anlsals
with numbers In the units to teens, but the revised report shows
animal numbers ranging frca 4o to 1000, Can this be straightened
out?
.
1 was unable to reconcile the differences in tha animal nuobers between tha first supplemental report and the origins! reports, 1 had inquired as to the changes in the numbers. As I recall,
2 was told that the sections had been renuaoered when the new slides were made and that a kty relating to the sets of numbers
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Dr- J.C. Caltadra July 18, 1975' P&8 - 2 - /
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'* would be supplied. This hat not been done, it say not be necessary ter AR0C10SS 1260 and 1242, but AROCLOR 1254 realins unresolved.
Insofar as I can see, the remainder of the reports appear acceptable.
Kindest personal regards,
Sincerely,
George J. Levinskas, PhD Kgr., Environeental Asseescent
and Toxicology
/bkp
at t
ccj Dr. George Roush, Jr., M.D.
B/P'd
|,;nni ?.72 10073*
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Product
Supplemental Report #1 (mailed)
ASOCLOH 126b
conclusion
'
slightly tuaorigenic
hepatoaM
3
range of test animal nos;
,,
P. 9
600 to 800
p. 10
1000 series
P* 11
70 to 100
p. 12
goo to 600
pP,. J134
00 to 700 700 series
Supplsoental Renort _.#2 iJCC delivayi*rt\
does not appear carcinogenic
7
100 to 300 800 to 900
10 to 40 fio to 200 200 to 300 200 to 300
'
>4
AROCIOR 1254 conclusion
hepatoma
slightly tuoorigenie
6
slightly tusoriganic
6'
AROCLOR 1242
conclusion
llightly tuaorigenic
does not appear carcinogenic
hepatoma
7
3
raase of teat animal nos. a* In report #2 as in report #1 for AROCLOR 1260 AROCLOR X2SO
,
8/S'd
Rim 773 10073!) .
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