Document ZBZOj7xGp30KeyK0DQbweJMBY

* >* ^ *?V ., *. - U-' ; :*v- i. .' 7*..^ >:-:k > >-v^ , * /4 ' ,V*'* . ^25 199) ;.' * :-&''y^--,;V. -.- ; . . ; .. - , ^ **" , '.' / ' `': . v - * *i>. . Zytr.1*'-; ,1 i r'. '.% ' V V,C'" -:Vr>"" -V\A'i ` *v-iV ;/' <* V i c <- 1 - fV- -*/* ; " - * ;'-*. , ; *< 'tr'V'" \'. '' '/.*- / ; ,r . i.t. -'* , ?'. ; r; ' CONFIDENTIALr'V'**;-'r;i'*:'' V' 'vA>;%V>Mr ` ' >- "'' Y * . '. V' >` ' i - >'- 'V.-;; i? \ .[ v .. . *J ' - '. " . > 1,. ' ' " 'f-v * ' ' 'Vw>- \ CL* t "-v" ' ** ,", -*.>(. :,, . - ,/ - A; 1v^ V ;^...^: -S-^vnvi. V'" - ;' World Register of Cases of ' ; '' ':v"--:V;V >:>!.?';/ - /v; v-. v, '' r '" \ T " " .r J_* '*. \ *'' \ 'r\ y: "i^ -' - - \.` [ V'V V\'""' L,r, ; Jr` r T*-* ' V ANGIOSARCOMA OF THE LIVER (ASL) ' > . . 4 y r* ` DUE TO yCM ; ^'V f" , v' v* " m r, \* ' r-`... ' %S T " ^ -V* REVIEW DATE * f 4, * T i FEBRUARY 1991 4^* hL 4!) 4!^ 4L t .-. r.'-vV-'U- *../ ` . ' \v- r (,* *- . I + V 1 ' **-1," 1 ' mn'+ ' i.-'' '' /.- ^ v ;. ' t -1- '-7 . *V* _ ". . v S \ \ ,4 `i Collated by: ' V"' ` `o * -. J. R. Dmmwright, M. D. Vista Chemical Company Manager Medical 900 Threadneedle Houston, Tx. USA v Telephone (713) 588-3044 Fax (713)588-3107, Tlx 794557 - r. Ya., t v r R&S157805 CONFIDENTIAL - A 000014 A /ME ASSOCIATION OF PLASTICS MANUFACTURERS IN EUROPE Brussels, 16 November 1992 To the recipients of the 'Angiosarcoma of the Livert Register Dear Sir/Madam, Dr J.R. Drumwright from the VISTA CHEMICAL COMPANY, who was in charge of the 'Angiosarcoma of the Liver' (ASL) Register and who produced its last issue in February 1991, has taken early retirement in August 1992. At the initiative of the Medical Group of the Vinyls Committee, the documents have been transferred to APME - the Association of Plastics Manufacturers in Europe, in Brussels, Belgium, who passed on the responsibility for maintaining the ASL Register to me. A new edition of the Register is planned for the beginning of 1993. With this in mind, I should be grateful if you could confirm your wish to receive the next publication by returning the attached form before 31st December 1992. Please indicate also any changes/additions or deletions for the next Register. In order to update our list as good as possible, may 1 ask you to report any information on retirements, change of receivers, change of addresses, etc. Thank you very much for your assistance. Yours sincerely, Fran9oise Drion M.D Enel CONFIDENTIAL - A 00001S Avenue E. Van Nieuwenhuyse 4 Box 3 B-l 160 Brussels < )i v 2 _ 2 \ f? 3 3 2 Q 7 Fm mvili 3 2- 3 0 " 3 3(> 3 ^ R&S157806 LIVER ANGIOSARCOMA CASES CIRCULATION OF REGISTER BAGSHAW Or I N N BAND Or P R BARRAT Or G BAXTER Or P BAYLAC Or BELLEC Or BENECH Dr N BENNETT Or B BERTAZZI Or P BEYNON DUS BISHOP Or C BORREUI F E BRAUN Or C L J BROGDEN M E BROUN Dr M G BYREN Or Oavtd CAMPION Or Catherine CARTER Dr J T CHIOZZINI Dr Giorgio CLARKE Or E A CONTASSOT Or J C COULES Or Sally DELORME Or F DEPLAN Or F DIETZ Dr H U DOLL Prof Sir Richard DQKBROWSKI S L S D00RN80S Or N DRUMURJGHT Or J R DUPONT G EMMINGER N ERNST Dr U EVANS Or A E J FALK Or H FAVRE Dr FIELDING Mias C CtWFIBEWTIAL FEBRUARY 1991 Hydro Polyaiers Ltd, Newton Aycliffe, UK Cancer Control Agency of British Coliabia, Vacouver, Canada AECRP, Coomentry, France University of Casbridge UK Atochaai, Chacny, France Rhone Poulenc, Aiiservitiers, Franee Maphtachiaie, Lavera, France ICI Hillhouse, UK Inst of Occupational Health, Milan University, Italy ICI Rtatcom, UK EMAS, Cardiff, UK Georgia Gulf, Delaware City, USA Akxo, Amhsai, The Netherlands ICI Runcorn, UK Shell, An Den Haag, The Netherlands Nobel Industrier, Sundsvall, Sweden Health l Safety Executive, Bootle, UK EMAS, London, UK Ospedale usfeerto I, Venice, Italy Ontario Cancer Foundation, Toronto, Canada Atochaa, Saint-Fens, France Shell Oil, Houston, Tx. USA Quebec, Canada Atocheai, Jarrie, France B F Goodrich, Akron, Ohio, USA taperial Cancer Research Fund, Oxford University, UK Dow Chanfcal, Midland, Michigan, USA DSM, Beefc, The Netherlands Vista Chemical, Houston, Texas, USA APME, Brussels, Belgius VKE, Frankfurt, Germany Berufsgenossenschaft der Cheaischen Industries, Numberg, Germany Lever Bros, Uarrington, UK Centers for Disease Control, Atlanta, Georgia, USA Atochaa, Montluel, France ICI Millbank, London, UK R&S157807 CONFIDENTIAL - A 000016 FI LUNGER J FINCHAN Ms Shirley FOA Prof V FORMAN Or D FRASE R U FRIEDEL Or H P GAFFEY Or W GILL1GAN Or. R. GIUDICE Dr S GOTTESMAN Or R T GOUGH M GROISMAN 0 HAMILL OP PW HILLMAN Dr D U HOWARD Or J K HOUE Susan R. HOWE Dr W HUMPHRY Or N F JOHNSON Roy N KAIPERT Or J H KALNAS Or J LAGAST Or H LANHAM Dr John LANOUZIERE Dr Claudine LAWRENCE*JONES Sir C LEE Dr F I LEESER Or Jenny LELBACH Prof Or WK LEVEOUE Dr G LEVISON Prof Dr 0 A LEWIS Or P LI GO Or R N LO KARTIRE Prof N LUSS R 0 LUSSATO Or Joserte MALTONI Prof C MATTIUSS1 Dr R MELTON B MIDDLETON 0 MONICA Mr MONTESANO Or R MOTTI Dr A A MUNDT Or C A MUNOZ MOUTON Dr M MacSWEEN Prof RNM NAKAMURA Or S NORTHROP Dr H L OSMAN Or J OWEN Dr R PAODLE Or G M Solvay, Brussels, Belgian Alberta Cancer Board, EtSnonton, Canada Inst Industrial Medicine, Milan, Italy Imperial Cancer Research Find, Oxford University, UK DiversiTech General, Akron, Ohio, USA Berufsgenossenschaft der Chemischen Industries, Heidelberg, Germany Monsanto Co, St Louis, Missouri, USA Occidental, Dallas, Tx, USA Montedipe, Venice, Italy The Vinyl Institute, Wayne, JiJ, USA Centre for Risk Management, Washington Electrochemical Industries, Acre, Israel Hamill Associates Inc. Annapolis, Md, USA Diamond Shamrock Corp, Dallas, Texas, USA University of Otago School of Medicine, Wellington, New Zealand CMA, Washington DC, USA ICI Runcorn, UK ICI Australia, Melbourne, Australia GenCorp, Fair lawn, Ohio, USA Dow Chemical Europe, Horgen, Switzerland Imperial Oil, Sarnia, Ontario, Canada Solvay, Brussels, Belgiun Dow Chemical, Midland, Michigan, USA Solvay, Tavaux, France Chief Medical Officer, ICI, London, UK Victoria Hospital, Blackpool, Lancs, UK ICI Runcorn, UK University of Bonn, West Germany CDF Chimie, AZF, Bully*les-Mines, France Guy's Hospital, London, UK Chemical Industries Association, London, UK Dipont, Wilmington, Delaware, USA EniChem, Milan, Italy Occidental Chemical, Pottstown, Pennsylvania, USA Atochem, Port de Bouc, France Institute di Oncologia, Bologna, Italy Envelope Returned No Address Formosa Plastics, Delaware City, USA Hydro Polymers Ltd, Newton Aycliffe, UK Neste Oy, Espoo, Finland IARC, Lyon, France ICI Duperial, Buenos Aires, Argentina University of Massachusetts, Amberst, Ma. USA Rio Rodano, Madrid, Spain Western Infirmary, Glasgow, Scotland Japanese PVC Association, Tokyo, Japan ICI Americas, Wilmington, De, USA Health l Safety Executive, Bootle, UK Herpenten, Herts, Ok USA ICI Central Medical Group, Alderley Park, UK R&S157808 CONFIDENTIAL - A 000017 PAOUET Or Christiane PARIS Dr A PATERSON Or J C PINAUD R PIRASTU Dr Roberta POSSBERG Or J PUECH Or A M PURDHAM Or J RAMBAUD Dr J RICHARD Or A ROBSON Mr* D ROSA Dr HS RUTY Dr J SALG Dr Joyce A SCHIPPER Dr H SCHUCKMANN Dr F SERONNE Dr D SCOURIS Dr G SIGRIST Or J S1MONAT0 Dr L SMITH Prof Allan H SMITH Dr P M SPIRTAS Dr R STAFFORD Dr J STANNECKER Dr E SULAIMAN Or TACHECI Dr H TAMBURRO Prof CH TENKHOFF Dr N TEPPER Dr ll TERW1ESCH Dr B THERIAULT Dr Cities THIIS'EVENSEN Dr E TOMATIS Dr L TONER H P VAN DER MERWE Or H J UAITEMATE H WEJDLJNG S 0 WELLMAN Dr J WEN Dr C P WILLIAMS Dr DMJ WILSON Prof R YORK J ZOBER Dr M A Atochem, Serquigny, France Rhone - Poulenc, Roussillon, France ICI Rincorn, UK Petroquimica Color*!ana, Carkagena, Colimtoia Istituto Super!ore di Sanita, Rome, Italy Wacker*Chemie, Munich, Germany Atochem, Brignoud, France University of Toronto, Ontario, Canada RP Recherches, Antony, France Rhone Poulenc, Roussillon, France Saskatchewan Cancer Foundation, Regina, Canada Petroquimica, Salvador, Brazil Atochem, St Aitoan, France NIOSH, Cincinnati, Ohio, USA University of Manitoba, Winnipeg, Canada Hoechst, Frankfurt, Germany Diamond Shamrock, Dallas, USA EKO Chemicals, Thessaloniki, Greece Shell Chimie, Berre L'Etang, France University of Podua, Italy University of California, Berkeley, USA Llandough Hospital, Penarth, UK HCl/NIH, Bethesda, Maryland, USA Somerset, UK BASF, Ludwigshafen, Germany Arabian Petrochemical Co, Saudi Arabia Hoechst AG, Frankfurt, Germany University of Louisville, Kentucky, USA Huts AG, Marl, Germany Air Products, Allentown, Pennsylvania, USA Huls AG, Marl, Germany McGill University, Montreal, Canada Norsk Hydro, Porsgrum, Norway 1ARC, Lyon, France Society of the Plastics Industry, Washington DC, USA AECI, Sasolburg, South Africa BF Goodrich, Cleveland, Ohio, USA Norsk Hydro, Sterxngsmd, Sweden Goodyear Tire t Rubber, Akron, Ohio, USA Chevron, Houston, Tx., USA BP Chemicals International, Barry, UK Harvard University, Cantoridge, Massachusetts, USA EVC, Brussels, Belgiun BASF, Ludwigshafen, Germany From: J. R. Drumiright, M. D., Vista Chemical Conpany 900 Threadneedle, Houston, Texas, USA R&S157809 CONFIDENTIAL - A 000018 CONFIDENTIAL Register of Cases of Angiosarcoma f the Liver Due to Vinyl Chloride Review Date - February 1991 As you're aware, Dr. Brian Bennett left ICI on September 30,1990. The responsibility for maintaining the ASL Register was passed on to me. All data has been reviewed, updated and prepared for the 1991 Register based on information supplied by Dr. Bennett. Your suggestions for change, additions/deletions for the future Registers will be appreciated. PREFACE: Acknowledgements, Significant Changes, Comments & Requests 1) The four new cases in the Register are: Australia 01; Germany 40; Italy 08 & 09. The Australian case is the first notified from that country. (Currently, two cases in the US are under review for confirmation of diagnosis.) 2) There have been no deletions for the 1991 Register. 3) Amendments from previous Register include new page for Australia; Table 2: Total Western Europe cases increased to 99 with world total to 161 cases of ASL; Table 4A, 4B, 4F, 5, 6, 7, 12: Recalculations due to new cases . 4) Based on current data, the following cases are still alive: France 15 & 28; US 33 & 36. If new information is available for these cases, please advise me. 5) Thanks are in order for new cases, information/clarification and reports to: Drs. Friedel; Johnson; Northrop; Lagast; Richard; with special thanks to B. Bennett. 6) Research: I respectfully request that each recipient of the Register continue to keep me informed of any new cases, etc. and/ or provide me with the name and address of the appropriate individual who can supply the necessary details. (A blank sheet is enclosed at the end of the Register to assist you in reporting the appropriate information.) Also, please continue to provide any relevant information about earlier cases, factory data, etc.) as well as individual retirements, changes of address, etc. for the Register mailing list. From: J. R. Drumwright, M.D., FACOM Manager Medical Vista Chemical Company P.O. Box 19029 Houston, Texas 77224 USA Telephone (713) 588-3044 Telex (713) 588-3107 CONFIDENTIAL - A 000019 R&S157810 ITVER ANGIOSARCOMA CASES (REVIEW DATE - FEBRUARY 1991) INDEX Table Sequence Australia..............................................................................................................................................J Belgium............................................................................................................................................... 2 Canada............................................................................................................................................. 3-4 Czechoslovakia.................................................................................................................................. .5 France............................................................................................................................................ 6-11 Germany.......................................................................................................................................12-19 Italy............................................................................................................................................ 20-21 Japan........................................................................................................................................ 22 Norway..............................................................................................................................................23 Spain..................................................................................................................................................24 Sweden..............................................................................................................................................25 UK............................................................................................................................................... 26-29 USA............................................................................................................................................. 30-38 Yugoslavia........................................................................................................................................ 39 Incidence of Cases per annum (Table 1).......................................................................................40 Distribution of Cases by County (Table 2)...................................................................................41 Pattern of Cases by Factory (Table 3)............................................ 42 Latency Periods (Table 4A)............................................................................................................43 Distribution of Latency Periods (Tables 4B-4H)..................................................................... 44-50 Annual Geographical Incidence (Table 5).................................................................................... 51 ASL Case Numbers by year of Death (Table 6).......................................................................... 52 ASL Case Numbers by year of first exposure (Table 7)............................................................ 53 Western Europe PVC Producers - Start-up Dates vs ASL Cases (Table 8)........................ 54-55 USA PVC Producers - Start-up Dates vs ASL Cases(Table 9)............................................ 56-57 Canadian PVC Producers - Start-up Dates vs ASL Cases (Table 10).......................................58 East European PVC Producter - Start-up Dates vs ASL Cases (Table 11).............................. 59 Japanese PVC Producers - Start-up Dates vs ASL Cases (Table 12)......................................... 60 South & Central American PVC Producers - Start-up Dates (Table 13)........................................61 Austra/Asian PVC Producers - Start-up Dates (Table 14).......................................................... 62 Middle Eastern PVC Producers - Start-up Dates (Table15).........................................................63 Number of PVC Factories in the World (Table 16)..................................................................... 64 Blank form for notifying new cases.............................................................................................. 65 R&S 157811 CONFIDENTIAL - A 000020 AUSTRALIA 1 ODUMIT AM) KFEttICt M 2 AMI OR INITIALS 3 DATE OF BllfN 4 (OFAIY LIVER AntlMircon Cases Review date February 199)) 3 FACTORY A hist vc fXFOSURE T Air or DIAGNCNIt a AGE AT DIAGNOSIS 9 VEAAS OF EXPOSURE TO DIAGNOSIS to YEARS Of EXPO SURE tt DA1E OF DEATH 12 HISTOLOGICAL CONFIRMATION 11 ESTIMATED EXPOSURE LEVEL M OCCUPATION OTHER CAREER HI GNU GUTS OTHER COtCNT* 01 n rb ICI lotany July 1M3 April 55 23 10 April Ye* low EVC waratw letter: Or NF Australia Nsy 1990 1990 u HuepFiry dilef SMftaan Medical Officer* ICI Jul*65 to Australia, Jim 1990 *ar.7 (20 ontha) Nediiai Autaelava Cleaner Mar.07 t* Aug,rt (0 years 5 ontti*) CONFIDENTIAL - A 000021 St8ZS LS'Std I t 1. BELGIUM 1 COUNTRY AND REFERENCE NO 01 23 NAME OR INITIALS DATE OE BIRTH 12.01.1] * COMPANY Solvey 0? sr 29 09 *0 Sotvey LIVE* Angiosarcoma Cases * (Review Pate February 1991) 56 7 8 9 10 11 12 13 14 15 16 factory FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS years of EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Jeieppc 00.07.SO 00.OS. 76 63 18 17 29.06.76 Yet Nigh Autocleaner Driller In a Nepatlc teats 14 yra loipdry In Oct 1974 1958-19*8 (2 yra) were normal. exposed to Polyworker Farmer Retired 200 ppm 3 yra (15 yra) Feb 1975 for 8 hr* Work In fleet Hospitalised per dey Ind, t chemi Nay 1976 end cal Industry certainly Coaplett under clinical and 500 ppm career details Inj6 to are flven In a 9m paper by autoclaves MUblet at at 1968-1972 In Arch. Self. exposed to Ned. Soc., 50-200 ppm Nyf. Ned. 8 hre per Trav. Ned, dayln Les. 25m 1977 pages autoclaves 601-622 1972-197* exposed to 50-200 ppm In auto- clave roam 1974-100 PC" 1975- 30 PP* SETISEO 1 Teb 1975 Jemeppe 20 08 62 00.10.79 39 17 9 23 10 83 Ye* 08.62-03. 63 01.67 -10.71 200 ppm 8h/day 04.63-12. 66 200 ppm Autocleaner Fireman since 5 yra 5 nthe 10 71. Operator 3 yra 9mthe. 1st sign July 79: Thoracic pain 07.79. Nepatlc testa altered 10.79. Positive echography 11.79. Nepetectomy 02.80, Chemotherapy. Information given In letter 12 Nov 1984 from Or De Sloover. eiazsissu 2. CANADA Sliw> 1 1 21 CDUNTNT AND reference NO NAME OR INITIALS DATE OF IREN CANADA 01 15.12.11 LIVEN Angiosarcoma Cases (Review Date February 1991) dat month yean All dates use OK system 4 56 2 0 9 10 11 12 11 14 15 16 COWART FACTORY FIRST VC EKPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS $HAU|i*9 1944 1955 41 11 11 02.09.55 Tea Reactor cleaner Operator Smoker polymerlaatlon 02 06.01.14 1941 1952 41 14 14 21.12.52 Tea Maintenance, Operator millwright, pipefitter Worked overtime Smoker 01 26.00.19 1941 1962 42 21 20 21.01.62 Tea Operator, foreman Worked Overtime Non-smoker OA 05.04.19 01 02.05.11 1945 1962 40 22 22 21.01.60 Tea 1944 I960 52 24 05 05.02.60 Tea Reactor cleaner Reactor cleaner Operator, * foreman, water cooling unit Worked overtime Smoker water cooling unit Worked overtime Smoker 06 15.12.19 1942 1921 51 24 21 10.04.21 Ttl Reactor cleaner Maintenance, millwright Worked overtime Smoker * 02 09.11.19 1946 1922 51 26 25 24.12.22 Tea Reactor cleaner Machine shop operator and poly mlt Worked overtIme Smoker 00 11.05.20 1961 1921 51 12 05 12.06.21 Tea Reactor cleaner Maintenance machine shop In plant 25 yrsl Smoker 09 19.02.21 1946 1924 51 20 26 04.09.24 Tea Furnace op. pipefitter maintenance '* Piper by Dr P DELORME In Aretalee d'Anatomle pathologlque Peris, 1928 Vot 21 No 2 pptOS-ttt claims tbit ease had both a hepatoma and AIL simultaneously. Worked overtime Smoker i CONFIDENTIAL - A 000023 W8zsis?a 3. CANADA Sheet 2 1-- 2 3 COUNTit AND REFCftENCE NO rani or IRIIIAll DATE Of IRIH CANADA 10 16.05.15 LIVER Angiosarcoma Cases - (Review Date February 1991) OAT MONTH TEAR All dales use UK system A COMPART 5 fACIORT 6 FIRST VC EXPOSURE 7 DATE or DIAGNOSIS 6 AGE A! DIAGNOSIS 9 10 TEARS Of EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 13 OTHER CAREER HIGHLIGHTS 16 OTHER CONTENTS Shiu(h<g*i 1953 1976 61 23 K 00.04.77 Tea Ratetar cleaner Furnace op. paintenance, packaging Ex-smoker ii 16 13.10.25 Gulf Shawlnlgai 1943 Rov 05 60 42 5 05.04.86 Tea High 1943-47 Operator 1 Siparvlaor VC Plant Retired 1972 (Age 47) Lettere (reel Dr Fernand Delorme, Pathologist 8 H albesu, IFG 12 oc H.09.20 Culf Shawlnlgai 1945 Mar 82 61 37 27 31.03.82 Tea Nigh 1945-55 Retired 1972 Letters from Autoclave (Age 52) Dr Fernand Operator, Delorme, PVC Resins Pathologlat 8 M llbesu, 6FG Low 1955-63 VC Manufacture Medium 1965-72 Autoclave Operator, PVC Resina 13 ss 10.06.26 TO Rlapara 1957 1967 60 30 23 26.1.87 TM 1957-70 Poly Cleaner Retired 1980 Information Uelland High 8 Operator (Age 54) from Or R W Dfett, 1970-80 Stftervlsor SFQ, 1988 low CONFIDENTIAL - A 000024 9L8/SIS1?H A, CZECHOSLOVAKIA LIVER Anftlosarcoawi Cases * (Review Data February 1991) 1 COUNTRY AND REfEREICE NO 23 NAME Oft INITIALS DATE OF ftIRTH 4 COMPANY 5 fACIOHY 6 MRS! VC EXPOSURE 7 DATE 01 DIAGNOSIS 8 9 10 AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS TfA8S Of EXPOSURE 11 0A1E Of DEA1N 12 HISTOLOGICAL CONFIRMATION 13 14 ESflNAIED EXPOSURE LEVEL OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER CfHlEMTS CZECHOSLOVAX! A 01 28.06.28 State Co Hovaty 01.p7.57 24.12.73 45 16 16 24.12.73 Yea Autoclave Cleaner IARC latter of 1-4-82 living dalalla from Prof A David of Centra Ind Hygiene end Occ dlieesei. 02 06.02.27 Itato Co Novelty 01.11.50 27.11.64 37 14 15 26.11.64 Yes Autoclave Cleaner IARC letter of 1-4-82 geve eomeiAiit altered date* for thle cote. 1 hive accepted the change! alnca the date* come from Prof A David of the Centre of Induatrlal Hygiene and Occupational datea come originally from KIOSH. CONFIDENTIAL - A 000025 9l-8Z9I.S'9d 5. FRANCE Sheet 1 1 2i COUNTRY AND REFERENCE NO NAME OR initials DATE Of HATH 01 M 13.04.24 4 COMPANY Rf> 5 factont NoussII Ion LIVER Angiosarcoma Cases * (Revleti Date February 1991) 6 78 9 10 11 FIRST VC EXPOSURE DATE OF DIAGNOSIS ACt At DIAGNOSIS HAAS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATS OF DEATH 00.01.44 18.02.67 43 21 19 19.02.67 12 HISTOLOGICAL CONFIRMATION Yea 13 14 ESTIMATED EXPOSURE LEVEL OCCUPATION Nigh Autoclave worker end cleaner 19 yre 15 16 OtHfN CAkEEN HIGHLIGHTS OTNEN COHNEHU *ef. Navlor et at Arch. Nal. Prof. 1 30 n* 3 Nov 75 p 171-177 02 SIN 01.04.11 PCUK Nrlgnoud 04.07.39 15.01.75 63 16 12 24.01.75 Tt* Nigh 2 yr* on Italian tef. (NIOSN no atonoMr origin G Bormeton at cement) 10 yr* on at "Nouvel la polymer- pretta leetlon medical*" 5 Nov 1977 p 735 03 NAV 04.01.20 RP St font 00.00.44 15.01.75 S3 29 29 29.06.75 Tea Nigh Polyworkert VOt production kef. Nety at 10 yr* ae 16 yre. it Arch. Nat. autoclave Italian POU. Prof. 1 17 n> cteenor, Shepherd, 6 Jin* 7? Coepouidlng Sawyer, Nason p 551-555 3 yre 04 HOR 22.01.27 PCU* Brlgnoud 19.10.49 16.01.76 49 26 26 04.01.76 Yea Nigh Nencmer production worker 8 yr*. PVC filtration 18 yr* Of 29.01.38 PCUX Brlgnoud 18.01.63 13.03.76 38 11 11 11.05.76 Yea Nigh Polyworkar UThorecotomy * if. P Coer*"-* 11 yrt 9th Feb 1976 et al coatat das he': 1 1 angiosarcoma 10 Sepi 2)Selntlgraphy 1976 loud ASl Previously had DNaeaorrhage bone from ASL anglotarcoma* 4)Nlght Alao Nepotectomy Plllchowskl ct at "La Nouvelle Press* Nedlcsle 7th July 1979 Page 2485. CONFIDENTIAL - A 000026 ZL8ZSlS'Sd 6. IMWt Sheet 2 LIVER Angiosarcoma Cases (Review Date February 1991) 1 2 3 A 36 7 8 9 10 11 12 13 1A 15 16 COUNTRY ANO REFERENCE NO HAME Ot INITIALS DATE OF IRTH COMPANY FACTORY MAST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS TEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH NISTOIOGICAI CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER highlights OTNEN C0M1ENTS 06 P* 1A.0A.3A PCIAC rlgnoud 01.03.58 12.08.76 A2 18 13 11.09.76 Yet Moderate (1958-1960) (NIOSN 2 yr* say* flltretlon 12.09.76) 10-11 yr* polyworker and work* lab? this man had AOL prior to AS. Am. da Nal. Prof. July *77 p 6A3 t 6. AOL was focnd In 1971 Five yrs befor* ASL 07 GIR 76.0A.i7 RP St AUban 01.07.50 Alter A9 26 22 02.07.76 Yes High Plant fora 1972-6 edsln Oled of death (NIOSN no men In sect Ion In septicaemia NIOSN consent) polymer St AUban Small liver ayt isation lesion found 00.07.76 after eutopsy OB 1 01.0A.3A Solvay Tavaux 23.03.57 03.12.75 A2 19 19 30.01.77 Yet Moderate 6 yr* pecker 1 autoclave clnr 1A yr* autoclave worker Ned been tuoel worker previously 09 RFX 08.10.1A RP St Fans 10.01.AS 26.0A.76 63 28 28 23.12.77 Yet Vary Nigh Polymer 10 yr* In operated A.76 19A8-1966 isation sulphuric Tor removal of lasser operator, acid Factory, tunour from Exposure autoeltantr, atorekeeper 1 liver and 1966-1976 autoclave genaral died after maintenance service* second surgical operation for bit lo bronchial fistula Paper by Dr Rety et at In Archive* de Naiades Professionals Vol AO No 6 1979 pages 7A1-3. CONFIDENTIAL - A 000027 8L8ZSI.S18U 7. (NANCE Sheet 3 LIVE* Angiosarcoma Cases - (Review 0te February 1991) 1 2 3 4 56 7 8 9 10 11 12 13 14 15 16 COUNTRY AND reference NO NAME OR INITIALS DATE OF IRTN to VP 24.03.19 COMPANY *p FACTORY St Fora FIRST VC EXPOSURE DA1E OF DIAGNOSIS 00.12.56 10.01.28 AGE At DIAGNOSIS 58 YEANS OF EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE 0A1E OF 0EA1N HISTOLOGICAL CONFIRMATION 21 21 10.01.28 TM ESTIHA1E0 EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS 81th Autoclave cleener 10 yre In mechanic*! engineering Industry 1946-1956 Died Of pulmonary eofcol Ism 5 dayl after Surgery 11 L 13.02.12 HP St Fora 00.01.41 12.08.28 66 32 31 13.11.28 TM Nigh 1941-1946 polymer- leetlon generel purpose worker. 1946-1922 VCN yntheele (MCI ( Acetylene) Foreman (egent dt meltrlee) 1972 retired - 12 16.08.14 PCUK rlgnoud 09.02.49 00.05.29 63 30 22 23.06.29 Yet Nigh Monomer production end polymer- leetlon operator 13 19.01.31 Solvey tavaux 23.09.63 26.06.29 40 16 13 22.08.79 Yet Autocleaner 2 yre. Auto operator 9 yre. Copolymer* 4 yre 2 yrs *s cycle Cigarette mechanic. smoker until 10 yre a* 1974. Ill all enameller In of 1922 ckj* to aanltary ware Oesophageal manufacture varices. Surgical Intervention 25.05.29 (right hepstectomy) H NJ 1 05-04-24 Chloe Chlmle (Formerly RP> St Fora 1943 00.02.81 52 38 36 29.07.81 Yet Very Nigh 1945-1975 1975-1929 1943-1925 All type* oF maintenance end Jobs on work Intermitt manufacture ently I malntenenc l 1925-1979 In VCN Poly Proceee __________ CONFIDENTIAL - A 000028 6l-8Z.SlS'8ti 8. FRANCE Sheet 4 --i-- 2 i country and REFERENCE NO NAHE OR INITIALS DATE Of HATH 6 COMPANY LIVER Angiosarcoma Cases - (Review Date February 1991) 5 FACTORf 6 ----------~7---------- ---------- A---------- 9 10 11 FIRS! VC EXPOSURE DAM! OF DIAGNOSIS AGE At DIAGNOSIS YEARS OF TEARS Of EXPOSURE TO EXPOSURE DIAGNOSIS DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 16 OCCUPATION 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS IS OCR 03.01.37 Chloe Chlmi* (formerly RP> St Font 07.07.SS 28.09.82 65 27 27 Alive Ye* Hlgh-20 yr Autoclave Moderate cle*n*r 7 yr* 1955-1962 autoclave operator 1962-1982 left Hepatectony 1983. J C Conttttot Letter* of 5 10 83 and 29 7 88. 16 GIM 13.07.22 CM oo Chlmle (Formerly APT St Font 17.10.61 05.01.83 61 61 38 03.06.83 Yet Hlgh-33 yr* Polymer Nat Moderate- ion Proee** Lou - 5 yr* Man Maintenance Iforker Retired 7*n 1979. J C Conte**ot Letter* of 5 10 1983 and 25 7 86. Health 1 Safety Agent 17 MAR 22.02.23 Chloe Chlmle (Formerly APT St Fon* 17.06.68 03.06.83 60 36 28 03.06.83 Yet Nigh - Autoclave Other tector* Retired 23 yr* Cleaner of St Fon* 01.01.79 1968-1971 Factory 1971- J C ContiSiot 197* L*tt< r of 5 10 1983 IS R U.07.62 Sotvay Tavaux 09.09.63 21.03.86 62 21 21 27.12.86 21.03.86 Hlgh-12 yr* Autoclave Lou 9 yr* Cleaner 09.03.86 Right Ncpatectoeqr 05.05.8626.09.86 chemotherapy for lingmetattaal* t partial remlialon. 08.86 - liver recurrence. 10.86 lung: evolution of the dlaease CONFIDENTIAL - A 000029 osezgis'su 9. FRANCE Sheet 5 -- lived Angfosercome Cases - (devlew Data February 1991) 1 2 3 4 SA 2 8 9 10 11 12 13 14 15 16 comm and REFERENCE NO FRANCE 19 NAME OR DATE OF INITIAL! IAIN COM2ARY MAE 1S-12.J2 Atochem FACtORY F1AS1 VC EXPOSUAE rlgnoud 02.04.5? 0A1E OF DIAGNOSIS 26.10.84 AGE AT DIAGNOSIS 52 YEAA3 of EXPOSURE 10 DIAGNOSIS 25 YEAAS OF EXPOSURE DA1E OF DEAIN 25 06.11.85 N1STOLOGICAL CONFIRMS!JON Y*S ESYIMATED EXPOSURE IEVEI OCCUPATION OTHER CAREER RIGNLIGNTI Nigh Autoclava operator grid cleaner OTHER COMMENTS Myocardial Infar ;tlon 1980 Coronary bypaia 1981. lall tr frN Dr Contaaaot 5.4.86 Portal 20 IR 02.03.23 Atochem rlgnoud 1951 22.12.85 63 34 22 26.12.85 In High Autoclava In othar porta flbroala frN operator and ol factory 26.04.24. Iha cleaner aInca 1946 lllneaa hr* dlagpoaed at presumably work ratatad on 20.04.24. Latter frN Dr Contatiot 05.04.86 21 da 01.10.40 *P std 1959 03.06.86 45 Hontlucon 22 4 28.06.86 Yes Nigh Autocteanar Malntananca 4 yara worker Hepatic teat May 84 normal. Hepatic teat May 86 thowed abnormal(tfet, latter frN Dr (arret 18.02.86. 22 Al 13.08.28 Atochem St AUban 01.09.58 05.11.82 59 2? 26 08.09.88 Yes Nigh 12 yaart 1958-20 Autoclava worker. In 1970-84 14 yaara In Control Ron 23 DO 02.02.22 Atochem It Fena 1944 1988 63 44 28 21.09.89 Yes High Autoclava Claanar t all PVC production Job* Lettera frN Dr Contaaaot, ktochem 2.12.82, 29 2 88, 24.01.89 Partial Hepetcctoeiy, Apr 88, Chemotherapy Information frN Dr J C Contaaaot Atochem, 1988/89 CONFIDENTIAL - A 0 0 0 0 3 0 tSSZSLS^U 10. France Sheet 6 LIVER Unglnircom Cxn {Review Dete February 1991) 1 2 I 4 5 6 7 8 9 10 11 12 13 14 15 16 COUNTRY ANO REFERENCE NO NAME OR INITIALS bate of 1IRTN COWART FACTORY FIRST VC EXPOSURE FEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS 10 EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COMMENTS 2* HA 08.12.28 Atochem Brlgnoud 194J 1988 62 45 35 01.12.88 tM Nigh PVC Product Off liver transplant May 1988, - 2 years Information from Or J C Contassot, MCV Detectfi n Atochem, 1988/89 - 3 years PVC Product oh maintenance - 30 years 25 1 02.OJ.JO fotvay Tavaux 1962 1988 58 26 23 07.05.88 YM 11 years) Polyclearter Nigh) - 5 years Polyttoor - 6 years 12 years Control Ron \ Low T2 years Primary Llvar Tuaour Metastates ling, brain, bone, spleen, klsRtey. Information from Dr Hlagast, Solvay, NovenSter 1988 26 MG 29.11.AO Solvay Tavaux 16.04.61 23.10.88 48 25 15 02.11.88 TO Nigh Autoclave 12 years Cleaner Low For 15 3 years years Died by haemorraglc rupture of the tuaour. No surgery, latter from Dr N Lagast, Solvay, 28.4.89. 21 ftc 1929 Atochem St Forts 1954 1988 59 34 30 00.01.89 Yes 1954-74 Autoclave Nigh Cleaner and 1974-84 all Pvc low production Job* Notified by Dr Contassot, Atochem, Deceefeer 1989 28 JO 1926 Atochem St Forts 1942 1989 61 47 20 Alive Yes 20 years 10 year* Nigh monomer analyst* (labs) 10 year* production PVC Notified by Dr Contassot, Atochem, Decruber 1989 CONFIDENTIAL - A 0 0 0 0 3 1 2S8ZSLS'8U n. GERHANT SbEi-l 1 COUNTRY AMO REFERENCE NO GERMANY 01 23 NAME OR INIIIALS DATE OF SIMM 00.00.30 4 COMPART 4 LIVER Anglosircema *** (Review Oite februory 1991) 5 EACtORT 6 FIRST VC EXPOSURE 7 DATE OF DIAGNOSIS 8 AGE AT DIAGNOSIS 9 TEARS OF EXPOSURE TO DIAGNOSIS 10 ua*s or EXPOSURE 11 OAIE OF death 12 NISTOLOGICAl CONFIRMATION 13 ESTIMATED EXPOSURE LEVEL 14 OCCUPATION 4 01.10.3i 19.09.60 38 12 12 25.01.69 T*S (NIOSN) Polyworker 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENT* 02 00.00.31 4 4 14.10.57 23.09.70 39 13 11 14.12.71 Tet (NIOSN) Polyworker 03 00.00.30 12 12 09.06.32 00.03.73 43 21 16 10.10.73 Tt! (NIOSN) Fill In* pettlcldt Reported infer non polymtr- trots! com 1tttloo with VC worktri In NIOSH llot of 31.3.77. Thli of count W ttrletly correct. However 1 wonder whether thli man bed high etpoture to VCM In hit cm filling spent Ion) 04 00.00.30 a 8 16.04.57 26.11.74 44 17 17 25.11.74 Tet (NIOSN) 200-300 ppM Polyworker 1 1958 HAS Cl Inlet! but high tttponry utoclemer dettllt In during 1 yr utoclemer For 1 yr peper by utoclemer Gokel ef -1 Virchows A't1' A Pith 1976 12 p 195-203 CONFIDENTIAL - A 000032 12. GERMANY Sheet 2 1 13 C0UR1AV AND REFERENCE NO NANE OR DAIE OF INITIALS NINTH GERMANY 05 00.00.36 (NIOSH gives as Case 06) A COMPANY II 06 (NIOSH gives as Cate OS) 07 00.00.32 00.00.26 OS \ 00.00.17 LIVER Angiosarcoma Cttn (Review Date February 1491) 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE OF DIAGNOSIS 8 AGE AT DIAGNOSIS 9 YEARS OF EXPOSURE TO DIAGNOSIS 10 YEARS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 15 ESTIMATED EXPOSURE LEVEL 1 OCCUPATION 1$ OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS Confirmed 11 02.04.60 10.12.73 38 13 05 16.12.74 Yes (NIOSH) *6 Chemle says "chemistry (aboratorlan In the Techno logical Research Department" (NIOSH says easlatant factory chemist which may be wrong translation) Reported inder non-polynerI tat Ion workers In NIOSH list Of 31.3.77 and 1.78. I don't think this Is a correct classification by NIOSH. The men may have been Involved In VCN polymerisation In pilot plant or In main plant. 16.12.62 00.00.75 43 13 12 09.01.75 PVC Manu facture Shift leader 15.04.54 12.11.75 49 21 21 13.11.75 Yes (NIOSH says 12) 19.07.54 06.04.75 .58 20 20 25.12.75 Yes PVC Manu facture end all work Inet autocleanlng 12 yrt (1954-66) Foreman lech Dev 8 yrs (1967-1975) 7 jpolyworker | 7 CONFIDENTIAL - A 000033 t'28ZSLS'SH 13. GERMANY sheet 3 ------------; 23 COUNIRY AND REFERENCE NO NAME OR INIIIAlf DATE OF 1RIN GERMANY 09 00.00.34 4 COMPANY 2 10 (KIOSK gives s Case 11) 00.00.36 2 11 (KIOSK gives es Case 10) 12 00.00.29 8 00.00.38 4 llVtft Angiosarcoma Casas - (Review Date February 1991) $ FACTORY 6 FIRST VC EXPOSURE 7 DATE OF DIAGHOSIS 8 AGE AT DIAGNOSIS 9 10 YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE 11 DATE OF DEATH 12 HISTOLOGICAL CONFIRMATION 13 ESTINATIO exposure LEVEL 14 OCCUPATION IS OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS 2 20.02.61 16.06.76 41 IS 13 24.03.78 Yes Nigh peaks 12 yrs poly- worker Incl ITS auto- slave (leaning Central roan 1 vr 2 01.01.61 00.01.77 40 16 10 07.03.77 Yes High peaks 10 yrs poly- worker |nei 17* auto clave cleaning 8 10.10.S3 28.06.77 47 21 22 28.06.77 Yea High 3 yre auto clave cleaner 19 yra (liter operator 4 00.00.61 00.10.77 39 16 6 07.10.77 Yes ? PVC Nervi lecture Autoclave worker for 6 yrs 10/78 Confirmed Average exposure first 9 yrs 150 ppm, Occ 1000 ppm. Next 3 yrs *v, 73 ppm. test, yr sv 3S ppm Averege exposure first 9 yrs 150 ppx, occ 1000 ppm. Lost yr sv 75 ppm. CUN letter of 21.04.78 1 s^/sissa 14. GERHANT tlVER An^lossrcomi Case* ' (Review Date February 1991) 1 country and REFERENCE NO 13 23 NAME OR INIUAIS DATE DF IINTN 00.00.H 4 COMPANY 7 (14) V 15 ENIOSH gives this ts Cese 13) 00.00.29 8 5 7 8 9 10 11 12 13 14 FACIONY FINST VC EXPOSUNE OAtt OF DIAGNOSIS AGE A! DIAGNOSIS YEANS OF EXPOSUNE YO DIAGNOSIS YEANS OF EXPOSUNE DAYE OF DEAtN HISTOLOGICAL CONFINNAIION EStlNATED EXPOSUNE LEVEL OCCUPATION 7 00.00.80 08.04.78 83 18 14 19.05.78 Yes Nat an Anglostrccm In his letter of 21 12 81, Hr Frledel Slid this WPS "Plstteneplthelksrzlnom Oer Spelserohre" (s csrelnaiM o the oesoffitgus) not ittrlbutble to VCM t not recognised ss on Industrlsl dtsesse 8 19.10.33 09.10.78 49 25 25 23.10.78 Yes 7 Autactive eteener end worker. Drier operator, liter ihlft leader 15 18 QTHEN CANEEN HIGHLIGHTS OTNEN CONTENTS F U Nest letter of 30th June I960 enclosing dote from Hr H P Frledel of EG Chemie F W Nest titter of 30th June 1980 enclosing diti fro* N P Frledel of 8G Chemle ulthdriwlng this esse Anglossrcone confirmed 09/79. Some detsll of this ( elso cites 9, 13, 15, 18 8 17 given In NNU Neport for 1978 9S8ZStS'y 15. f GCKHMT Sheet 5 1 23 COUNTRY AND REFERENCE NO NAME 0* INITIAL* DATE OF IIRTH 16 00.00.23 4 COMPANY 4 17 (NIOSN gives s Cite IS) 00.00.37 4 18 00.00.13 5 19 00.00.23 4 5 FACTORY 4 llVtR Ahgtosreom Cases * (Review Date: February 1991) A78 9 10 11 12 13 14 FIRST VC EXPOSURE DATE OF DIAGNOSIS age at DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 10.01.33 07.08.78 55 23 20 07.08.78 Yes Nigh Autoclave (lelbach ASL end worker till suspected Kepatocellular 1964. ASl at Feb 1975 Carcinoma Leader era! master laparotomy) 4 01.11.61 14.08.78 41 16 11 28.08.78 Yet Nigh Autoclave worker 5 00.00.53 25.12.79 66 24 21 25.T2.79 Yes Autoclave Worker 4 18.10.34 00.08.79 34 25 18 22.02.80 Yes Nigh Autoclave Metasteslng Worker ASL 15 16 OTHER CAREER HIGHLIGHTS OTHER CONTENTS Angiosarcoma confirmed, full details of Illness since March 1973 given In NRV Med Insp Rep for 1978. Different details given In "VC Associated Disease" by Letbach and Marsteller <1981) p71. No Angiosarcoma Confirmed, Amual report of the North thine Westphalia Medical Inspectorate for 1978 pages J47-377 gives full details. Vinyl chloride disease diagnosed 02-02-73. Oesophageal varices. Radiological ly confirmed aero osteolysis. Dr iesche tetter of 13-04-82 to Dr W G F Adams CONFIDENTIAL - A 000036 ZSQZSIS'ffU 16. GERMANY Sheet 6 1 I2 34 5 6 LIVER Angiosarcoma Cases < Review Date: February 1991) 78 9 10 ii 12 13 14 15 16 COUNTRT AMO REFERENCE NO 20 21 22 NAME OR IMIIIAIS DATE OF FIRST VC BIRIN COMPANY FACTORY EXPOSURE DATE Of DIAGNOSIS age a? DIAGNOSIS 00.00.15 4 4 14.02.61 00.04.80 65 00.00.13 4 00.00.21 4 4 01.01.62 00.09.79 pronounced clinical liver ipptiM) 4 15.10.61 28.08.80 66 59 YEARS OF EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE DATE OE DEAIN HI5TO LOGICAL CONFIRM* At ION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHT! OTHER CONTENTS 19 13 19.10.80 u* Nigh Autoclave Neemanglo Worker EndothellcMl* of liver Ith Metastasei 18 13 19.06,80 Yes 1 Nigh Autoclave Haemanglo| Worker and Endothel Iona uorked In of liver with drying ehop Hetattasea Dr letche 1 ,'tter of 13-04-82 tc Or W G F A'lams Dr lexche letter of 13-04-82 to Or W G f Adam 19 11 06.12.81 Te* High Autoclavt Chargehand, Dr Geicha tetter of Metastesli9 Worker subsequently 13-04-82 to ASl Foreman Or W G f Adams 23 00.00.27 8 8 1955 26.03.79 52 24 21 29.09.81 Ye* Nigh Chemistry (300 ppm) Worker Primary hepatocellar carcinoma; proliferation of the slnualodel cell* ulth alnusoldel ectesle. frledel letter 23.12.86. 24 00.00.28 8 8 1969 11.10.82 54 13 12 28.05.83 Yes Nigh Autoclavt (>300 ppm) Cleaner Prof Eder (Munich) letter 22.08.83. Frledel letter 19.04.85. 23 00.00.23 8 8 1960 28.09.81 58 21 13 14.01.83 Yea Nigh Polyclev* Worker and Autoclavt Cteanar Prof tetmalr (Munich) tettar 22.08.83. Frledel letter 19.04.85 (2*) Deleted n advice o Dr Tenkhof Decoder 19 9i AlcoholIc ClrrhotIt not VCM as loclated. 27 00.00.28 4 4 1955 18.01.83 55 28 IB 02.03.84 Yea Nigh Autoclavt Lelbech. cleaner till Frledel tetter 1972 19.04.85 i CONFIDENTIAL - A 000037 17. GERMANY Sheet 7 1 COUNTRY AND REFERENCE NO 28 29 10 11 12 11 14 IS LIVER Angiosarcoma Cases (Review Data February 1991) 2 i4 s 6 2 8 9 10 it 12 ii 14 15 16 NAME OR INITIALS DATE OF FIRST VC 9IRTN COMPANY FACICiY EXPOSURE 21.11.21 2 2 01.10.60 DATE OF DIAGNOSIS 11.08.85 AGE AT DIAGNOSIS 61 YEARS Of EXPOSURE TO diagnosis 25 YEARS OF EXPOSURE date of DEATH 25 25.08.85 HISTO LOGICAL CONFIRM* AT ION ESTIMATED EXPOSURE LEVEL OCCUPATION Yea Nigh Proem worker 1924-84 01.10.60 11.01.84 PVC production, egltator re* OTNfN CAtlfl NICNLIGNTf OTHER COMMENTS Amuat VCM acraanfng 24.04,65: no eanplalnt, no abnormality datactad. 1970 two*third* gattractomy for ulcara. 1971 Coronary throatootig 1983 famoral Implantation 1964 Pulmonary aafcol lam and pleufopneunonla* Landcra lattart 18*09.65 re* 04.02.67. 00.00.22 2 2 1962 15.02.81 61 21 19 15.02.84 Yat Nigh Chamlftry worker Ne*angloterk(w* frledel letter 21,12.86. 00.00.12 4 4 1951 02.01.80 62 29 25 25.05.81 Yaa Nigh Polyworker Shift leader Neeawngloterkome. Frledel letter 21.12.86. 00.00,21 8 8 1951 10.06.85 61 12 20 11.01.86 Y* Nigh Autoclave cleaner Neeiaeng 1 oaarkoma, Frledel lettera 21.12.86, 15.11.89 4 fendet 16.2.89. 00.00.10 8 8 1955 00.04.85 55 10 21 15.02.86 Yaa Nigh Polyworker Autoclave cleaner 00.00.12 8 8 1951 19.08.81 67 30 21 25.01.85 Yaa Nigh Autoclave Cleaner, Chenlatry Worker Neenangloaarkcm. Alio Developed Cholengloi*" - frledel lettera 21.12.6!, 15.11.09 and F.-ndet 16.2.89 latter fre* Dr Frledel 15.11.89 00.00.34 ( 4 1956 11.05.85 51 29 16 12.09.85 th Nigh Shift leader letter fro* Dr frledel 15.11.89 00.00.24 4 4 I960 18.2.21 49 5 >4 16.10.84 Yaa Nigh Autoclave Cleaner 1925 dleeeie of liver perenthyM; at left 805. latter fro* Dr Frledel 15.11.89 CONFIDENTIAL - A 0 0 0 0 3 8 ezezstssy 18. CffMANT Sheet 0 llvfft AhglosArtcnv Cittt (ievlet# Date Februiry 199H I i34 5 e 7 0 9 to 11 12 11 14 IS 16 COUNTRY AND REFERENCE NO Ku 1 }? H j* it 1* NAME ON DATE OF COMPANY FACTORY INITIALS BIRTH 99.99.11 4 4 9tM.lt 99.99.11 4 4 4 4 99.99.41 4 4 M99M 4 4 first r FJtrOSURE ItSS Ittt f list ittt Ittt OATEOF DIAGNOSIS 19.91. it AGE AT DIAGNOSIS S? TEARS OF EXPOSURE ro DIAGNOSIS IS K4M OF EXPOSURE IS DATE OF DEATH lt.tl.lt IIISTO LOGICAL CONFIRM AT10N Tn 9t.tt.IS lt.9S.lt 19 H It St t 9S.9t.lt Tn 19 lt.9t.lt Tn 99.l9.lt *4 It s 9S.ll.lt Tn 19.91.1? 47 It 4 lt.9t.ll Tn ESTIMATE D EXPOSVRR LEVEL HHk W%* Hit Hlfk OCCVPA TION AMotiam Woritr ImA Am. *i Uainm lAt mttthmt Uttrtm Mtn mmMir AmHtltn OMmr OTHER CAREER HIGIIUG UTS OTHER COMMENTS Lrtttrfrom Dr.Frk4ti tS.tl.tf aai Information frem Dr. Tt*kPi(s/T Drt.t* LrOrrfrom Dr. Fht4tilS.ll.t9 tj*rtfrom ft. FHMMIS.ll.lt Ptmlaa/him 74-t4 t0% Lattr aa IM% Lrttrrfrom Dr. Ftit4ti IS.II.99 aW formation from Dr. Teakhojf Dtc t9 FtmSnfitm Tl-t? Lattr an CtKiiamthtarctm*. ) hbttiofleoOf LtOtrt from Dr. Ftifit I5.lt.t9 oo4 27X96 CONFIDENTIAL - A 000039 0e8ZSLS'?d 19. ITALY Sheet 1 1 |2 3 COUNTAT AMO REFERENCE NO NANS Of! initials DATE Of NINTH 01 (On NIOSH Supple mentary list) LG 15.06.34 4 COMPANY PANSAC 5 FACTORT Mira Venice 6 MRS! VC EXPOSURE 00.00.65 LIVER ngloorcoM Cnn (Review Date February 1991) 78 9 10 11 PATE Of DIAGNOSIS AGE AT DIAGNOSIS YFARS OF EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE DA1E OF 0EA1H 19.04.71 36 06 03 16.04.71 12 HISTOLOGICAL CONFIRMATION 13 14 ESTIMtlD EXPOSURE LEVEL OCCUPAYION PVC Sag extruder 15 16 OINER CAREER HIGHLIGHTS OINER COMMENTS l rlmary tutxxjr may have been perlcardlua. Not homo geneous with other cases. a a** 02 5E 13.11.29 Nantedlton Porto Harghera 00.00.57 13.12.72 <3 15 06 27.12.72 Yet 1 Polyworker * ft* 03 VG 14.03.20 Solvay Ferrara 00.01.53 10.07.75 55 22 21 10.07.75 Tea High Autacletner 1972-5 did 8 yrt (1953- a variety of SI) Autoclav Jobs operator 12 yrt (1961 Including PVC packing. 72) ftft 04 f* 20.07.37 ANIC Ravenne 00.04.59 00.01.81 43 21 21 30.03.81 Tea 12 yrt - 1 yr - Never cleaned Very High 5 yrt - Monomer operator autoclaves. See paper by CHIAPPINO at ftft Non-smoker, Hedlua 20 yrt at Hed Levoro Consumed Autoclave Vol 6 (1982) little 4 yrt - operator 1 pp 555-563 elcohel. No Lou other dutlet AOL. In tutpent- lon polyemr- Itatlon. Area Foreman In tame Dept since 1975. 05 G Danesln 19.03.37 PANSAC Hire 00.00.67 07.03.83 Venice 46 16 8 06.04.83 ret Kedlut-7 lag extruder High 1967-1975 Coaiaerclal Oept 1976- 1983 S Pagllalunga telex of 2 Aug 1983 * See Haltonl Ned dl Levoro 5 p445, 1974. Further detalta In letter from Dr Montesano of IARC on April let 1982. * Alto tee Haltonl and Rondlnetle In Acta Oncologies Vot I I960 pages 35 A9. CONFIDENTIAL - A 000040 legzsi-s^u 20. IIAIY Sheet 2 1 23 COUNTRY AND REFERENCE NO NAME ON INITIALS DATE or NINTH 4 COMPART LIVER Angiosarcoma Cases (Review Date February 1991) 56 7 R 9 10 11 12 13 14 15 FACTORY nisi vc EXPOSURE YEARS Of DATE Of AGE AT EXPOSURE TEARS Of DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF 0EA1H HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHER CAREER highlights 16 OTHER COMMENTS 06 GZ 21.08.38 Nontedlaon Porto 01.10.60 06.12.85 49 25 25 13.02.86 Yet High PVC Narghera, 1960-71 manuFactura Venice HedlU* It yeart as 1971-74 Autoclave low cleaner 1975-85 1960-71. 14 yeara In Control Rooia 1971*85 letters fro* Or Chlotilnl, Venice, 22.09.87 and 11.01.88 07 AT* 09.02.25 Roplefen Ternl 1958 21.01.86 60 08 U.L. 03.06.36 i.V.C. Ravema 02,10.61 10.07.89 53 Italy ------------------- m-------------- fc.b. W.TC.'B Cooperative Ravenna Candlano Italy HOOT 65 28 22 05.04.86 Yet 28 28 21.09.89 Yet IT"" OD tl.08.fct Yet 1958-74 Nigh 1974-80 Hedlua Maintained vc Machlner (not operating or cleaning autoclaves) vc levels reduced Fro 1 1973/74 Information from la medicine del lavoro, Italy, Vol 79 No.1 Jen*Feb 88, and Dr lenetta, EnlChen. 1961-66 autoclave 02.10.'61 - 02.04.<63 >500 ppe cleaner for 1967-72 16 month** 500-200 autoclave Pt* 1973*75 operetor end reactor 200*50ppn eree 1976-78 operetor 50-5pjm 1979-89 5ppa J972-fciV' helper In Retired 200<5ppm reactor ara 31.03,<83 1982-85 <5pp bagger jiIIIII.......... ---I------------------ 1--------------- 1-------------------1------------------------ 1------------------ 1---------------------- 1-------------------- L CONFIDENTIAL - A 000041 21. JAPAN IIV*N Angiosarcoma C**ej * <f*vlew D*tR February 1991) 1 2 3 4 56 7 8 9 10 11 12 13 H 13 16 COUNTRY AND REFERENCE NO NAME ON INITIALS DATE OE HATH COMPANY FACTORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH NISTOEOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER HIGHLIGHTS OTHER COMMENTS Ot torn))! 01.00.22 MltAUl Nagoya 00.0*.33 24.10.71 33 22 13 24.10.73 Ye* PVC Assoc 13 yr* auto Mori loaliu says not clave known. cleaner Japan 1964 Time* assigned to Indicated different on 23.10.73 work since exposure* had III often, at^ health 3000 (pa (R> ( to 1974, > 0? SC 02.08.39 Ranegafuchl Osaka 00.11.S8 10.08.76 37 17 13 10.08.76 Yet Not known In polyaiar- Chemical laatlon work Including autoclave cleaning Japan Tine* 23.10.73 t Japanese PVC Atsoc letter* of 31.03.78 6 30.11.87 Japan*** PVC Association letters of 31.03.78 t 30.11.87 OS TS 01.09.30 Mitsui Toatsu Ngoy 00.07.83 26.06.83 3* 20 3 14.09.83 Ye* High 3 year* Autoclave cleaner letter fro* Dr Naksnjr*, Japanese PVC Association 30.11.87 CONFIDENTIAL - A 0 0 0 0 4 2 EE8ZStS^y 22. NORUAT LIVER Angiosarcoma Casa* (Review Oat* February 1091) 1 2 3 A 3A 7 0 9 10 11 12 13 H 13 COUNTRY AND REFERENCE NO NAME ON DATE Of INITIALS HATH COMPANY FACTORY FIRST VC EXPOSURE DAIE OF DIAGNOSIS AGE AT DIAGNOSIS TEAAS OF EXPOSURE 10 DIAGNOSIS TEARS OF EXPOSURE DATE OF DEATH histological CONFIRMATION ESTIMATED EXPOSURE LEVEE OCCUPATION OTHER CAREER N1CNLIGNIS 16 OTHER COFflEHTS 01 AN 23.12.13 Mortk Neroy* 00.03,30 21.12.71 56 22 21 W.01.72 TM High foreman t Hydro Autoclav* tigwrvlaor Continued by Dr ThlItEventan of HR. At APME NtR of 9 Jute 1978 Hr P Rangnes ateted that AR had bean a member of * itei\t-if> teen. VCN S PVC Her* mad* In tame building. The VCM wet made from acetylene CONFIDENTIAL - A 0 0 0 0 4 3 23. SPAIN LIVER Angiosarcoma Cases - (Review Date February 1991) 1 2 s 4 SA 7 8 9 10 11 12 13 . 13 COUNTRY AND reference NO NAME M DATE Of INI1IAII IRTH COMPANY fACIORY FIRST VC EXPOSURE DATE OF DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE 10 DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION 01 HER CAREER RIGHUGHTt 16 01 HER COMIENtS 01 MCG 26.03.40 Hlapavlc orrelovep 01.02.64 10.11.89 49 23 13 09.11.89 Yes mh Autoclave fro* 1.1.78 Cause of death: 12 years Operator production of mil tl pie 12 year*. hydroyen cerebral peroxide haemorrhagei, Radius latas No sietaitatlt. 1 year 1 year letter frost Or latstt, Solvsy, 04.01.90 CONFIDENTIAL - A 0 0 0 0 4 4 SS8Z91 S'SU 24. sum* ' COUNTRY AND REFERENCE NO ----- ------ * !1 5 NAME OR INITIALS OATE OF II RIFF COMPANY FACTORY 6 FIRST VC EXPOSURE 01 m 02 L 21.06.27 Kemtnord Sixidsvall 14.08.51 27.11.11 temanord Sundivtl1 00.01.45 llvt* Anglosarcoam Casas - (Review Date February 1991) 7a 9 10 11 DATE OF DIAGNOSIS * 20.10.70 AGE AT DIAGNOSIS 4] YEARS OF EXPOSURE 10 DIAGNOSIS 19 YEARS OF EXPOSURE OATE OF DEATH 18 20.10.70 00.08.72* 61 27 27 16.08.72 12 HISTOLOGICAL CONFIRMATION rt Ytft n 14 ESTIMATED EXPOSURE LEVEL OCCUPATION Nigh Polyworkar VCH production 15 other CAREER HIGHLIGHTS 16 OTHER comments Mr Sjoelln'a letter of 28 March 1978 confines tl was a monomer worker who w*i heavily exposed, probably even store so than a normal reactor cleaner 01 HE 10.06.10 Kaaianord Sundsval 1 00.05.47 18.01.76 65 29 21 19.01.76 let Nigh Polyworker 04 At 16.11.14 Atmonord Sintsval I 00.00.46 12.05.77 62 It 11 12.05.77 let Nigh 1946-1958 polymer- last Ion worker (12 yrs) 1 1958- 1977 foreiaan (19 yra) In first 12 yra of eaployieent had been heavily exposed. In 1974, liver abnonaalIty and necrosis diagnosed. Data confirmed In Dr D lyren letter 18.8.77 to CEFIC 05 12.01.19 Kcmsfiord Sundsval l 11.05.64 22.11.80 61 16 16 22.11.80 Yet Nigh 1964-1970 6 Year* centrifuge low operator 10 Tear* 1970-1980 drier operator letter of 2nd Nov 1981 from Dr David Syren * In hi* latter of lit April 1982, Dr Montesano of IARC say* Sweden1* National toard of OS Health (Ives 20-02*70 a* data of diagnosis for Caae 01 and 15-03*72 for Case 02. CONFIDENTIAL - A 000045 988/StS?b 25. 4 UK sheet 1 --i-- 2 i COUNTRY AND REFERENCE NO NAME OR INITIALS DATE Of I1RTM A COMPANY LIVER Angiosarcoma Cases * (Review Dete February 1991) 5 FACTORY 6 FIRST VC EXPOSURE 7 DATE OF DIAGNOSIS fl AGE AT DIAGNOSIS 0 YEARS OF EXPOSURE 10 DIAGNOSIS 10 YEAAS OF EXPOSURE 11 DAIE OF DEATH 12 HISTOLOGICAL confirmation 13 ISIIMAIED EXPOSURE LEVEL 14 OCCUPATION 13 OTHER CAREER NIONLIGNIS 14 OTHER COMMENTS yx 01 Uj 20,04,01 ICI Hllthouse (M.04.4A 03.12.72 71 20 22 03.12.72 Ye* 500 ppa 1044-7 VCR (Fox t (Foi 1 1047-8 Drier Collier Collier 1948-41 paper uy) paper Autoclave 23.12.72) ay* operator 23.12.72) 1041-44 Prior Lee and Harry lancet 20-04-74 page* 1316-8 (02) 03 iJU 02.04.17 IP irry 00.02,44 00.12.74 37 00 24.12.74 Yet High Autoclove cleaner Dubloue fabrication caat - Exposure United to 2.44 - 9.60 04 JSR 23.04.20 ICI NlldinJit 24.04.34 00.04.70 SO 25 10 12.10.70 Yet Medtim* 1054-5 Era-war flah high 90Inf packer Plant 1010-43 army 1055-4 vehicle Drier Plant Maintenance 1954-8 Autoclave 1045-34 flth packer worker 1058-41 ChargeDand Drier Plent 1061-72 Foremn C 2/3 Plant CONFIDENTIAL - A 0 0 0 0 4 6 ^Eezgiaw 26. UK - shut I UVEA Angiosarcoma Catoa (Keyleu Date February 1991) 1 "T* 3 commit ado j name oa AEFEAENCE INITIALS " DATE OF HATS OS UK 30.03.U 4 COMPANY so s TACIOAt Sarry 6 FIRST VC EXPOSURE OS.01.SI 7 DATE OF DIAGNOSIS 00.10.79 S AGE At DIAGNOSIS 65 9 TEAAS OF FKPOSUAE 10 DIAGNOSIS 28 10 11 YEARS or EXPOSURE DATE OF DEATH 21 19.11.79 12 HISTOLOGICAL CONFIRMATION Yet 13 14 ESTIMATED EXPOSURE LEVEL OCCUPATION 1951-52 Polycteanar 1952-55 lataa 1955-60 Polyfloor 1960-64 Poly Chargehand 1964-70 Charging operator 1970-72 Drier operator 15 16 OIAEA CAAEEA HIGHLIGHTS OTHER CONTENTS Further Information 198> from Or P M Smith anl Or 0 M J III. Ileam 06 GEP 1931 IP Sarry 1962 09.01.80 48/9 18 12 09.01.80 tea 7 yra Poly Floor Operator 5 yra Creeaer on Poly Floor Further Information 1989 from Or P M Smith and Or 0 II j Will learn 07 *ca 26.04.20 OP Sarry 1963 00.00.SO 60 17 8.2 13.06.80 tea Polyclaanar 1963-5 Pecovary 1965-1971 further Inform ation 1989 from Or P M Smith t Or 0 M i UK liana OS UTN 0S.0S.24 8P Barry 19.09.SO 27.11.81 57 31 24 25.12.81 Tea 1950-1958 1950-51 1938-1948 further 500 n* Autoclave Motor Mechanic Information 1968-1974 operator 1948-1950 1989 froa 200 ppm 1951-1957 Operator on Or P N Smith Chargeman Acetylene and Or 0 M i autoclave Production Ulltlama building Plant 1957-1974 Shift aupervlaor autoclave building - Never cleaned autoclavea but supervisor's Job entailed entering autoclavea to Inapect them CONFIDENTIAL - A 000047 88Z9I-S'SH 27. UK Sheet 3 1' *^ 3 COUNTRY AND ! NAME 0* REFERENCE NO INITIAL* DATE Of felNIN 4 COMPANY 09 EIGP 07.05.23 IP 10 CJt 0A.M.47 P $ FACTORY larry Barry LIVER Anglosarcane Cases - (Review Date February 1991) 678 9 10 11 FIRS! VC EXPOSURE DATE OF DIAGNOSIS AGE At DIAGNOSIS YEARS OF EXPOSURE 10 DIAGNOSIS TEARS Of EXPOSURE DATE Of 0EA1N 15.02.30 02.03.83 58 33 29 24.02.83 27.M.66 01 03 M 37 18 4.2 16.05.84 12 13 14 15 16 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTHER CAREER NIGNLIGHTS OTHER comments Ye* Medina Potyvorker 2 year* on Acrylonitrile R**ln Plent. Al*o prior to 1950. 4 year* rat maintenance. 3 year* motor car pelntehop. 2 year* In Graving Dock. Yes Nigh 11 P6lyeU*n*r Heavy goods Information month* (300 1966-67. vehicle driver given In P**). Lou- *pr*y-drl*r uitll final letter 18 month* bagger 1967- (line*. 18.06.84 from (50 ppm). 68. Dr D M J Ned list - tou-doun Kill lam 21 month* tripper (200 ppm) operator 1968-70. If GLP 08.05.28 p larry 19.12.65 02.06.85 57 r 12 JT 24.01.37 ICI Hltlhouse 16.09.57 03.06.85 48 19 16 02.06.85 Ye* High Polycleaner 1965 -69 1965-68. Med 69-79 Service Lou 79-82 operator 68-69. Poly Operator 69-79. Leading Hand 79-82. 28 28 06.12.85 Yes Lou 1957-39 Spare man, High 59-74 bagging 1 Lou 74-85 floor 1957-59. Autoclave Operator 1959-85 Letter of M.06.85 Dr Paul Smith and letter of M.06.83 Dr D M 0 Evans Oesophageal haemorrhage due to oesophageal varices due to Angiosarcoma of liver Utter 26.06.65 Dr F I Lee f CONFIDENTIAL - A 000048 6882S l SSU 28. UK Sheet 4 LIVE* Angiosarcoma Case* - (Revltv Data: February 1991) --; 7 i 4 56 7 89 10 11 12 13 11 15 16 COUNTRY AND reference NO NAME OR INITIALS DATE OF BIRIN COMPANY FACTORY FIRST VC EXPOSURE TEARS OF DATE OF AGE AT EXPOSURE years of DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATN HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE ATION 1EVEI OCCUPATION ii NJ 02.03.1B IF Berry 1968 Jen 86 17 18 02.06.86 Yes Nigh lOM High Polyeleaner 1968-49 Central Depot 1969-70 PolyTloor 19/0-1971 OTHER CAREER NlGHLIGNTf OTHER COMMENTS Moved to Remained well, working Acrylonitrile actively, wtlt Jen 1986 Plent taitll left IP T981. Mrneger of 1C 1 SS ltd at Cardiff Airport 1981-86 H GS 15.06.1 BP try 07.07.66 27.08.87 15 21 11 01.12.88 Yes 10 months Pol yeteener Nigh 1966-67 10 years PolyTloor constant worker et timer Medlisa between but on Inter 1968-1982 mittent Jobs letter* from Or DW Event, Pathologltt, Penerth, Welet end Dr DMJ William*, BP, Barry IS icp 21.08.2 8P lerry 1956 19SS 66 12 16 01.05.88 Yes 9 yeert Poly eleener I ) Information from Nigh 5 year* Nedlue 2 yurt Operetor ) glow 1 rcovery)E''P*ure operetor ,period. | y | | Intermittent Or 0 M J Wit Item, IP, and Dr Paul Smith, Pathologlet 1988. low Operator ) 16 NT 25.05.2 let Hltthouse 1963 1988 66 25 12 12.11.88 Yes 1 year ) Petker low ) 9 yean) Nigh 2 ynri) low ) Autocleve Operetor 17 RN 11.01.11 tel Nlllhoute 08.01.61 1989 58 26 25 17.09.89 Yes 1961-61 Peeker low 2 month. 1961-71 > Nigh ) Autocleve (11 yean 1 Operetor 1971-88 1 25 yeert low (11 yeen > Repetlc flbrotl* 1971 Oteophegeel verlcet Porta-ceval (hunt 1975 Information from Dr 1 Rennett, 1C!, and Dr f 1 let, lleckpool Vlctorie Nofpltet 1988. Intonation from Dr 1 Rennett ICI, end Dr f 1 lee, lleckpool Vlctorie Notpltel, 1989. CONFIDENTIAL - A 000049 omstssa 29. USA Sheet 1 LIVER Anglo**rcome Cases * (Review Date February 1991) UK system of dates DAT - MONTH * YEAR 1 2 i A 56 7 8 9 10 " 12 u 14 15 16 COUNTRY AND reference NO NAHE OR INITIALS DATE Of ltH COMPANY fACTOAT FIRST VC EXPOSURE DATE 01 DIAGNOSIS AGE AT DIAGNOSIS YEARS OF EXPOSURE TO DIAGNOSIS YEARS OF EXPOSURE DATE OF DEATH histological CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION OTNEI CAAEEN NIGNLICNTS UTHER CJFttEHTS oi - Ctrl Park* 17.10.iJ H f V . -JT ~ i Z'A/ 19.08.33 re ' " Loultvltle 09.12.48 0J.0J.7J kfcil UA <#**' .AObVltNt loultvilli 15.11.55 00.05.70 49 J7 05 Edward iJ.05.1l re Dinwiddle loulavilla "77 15.01.24 Jer loulivlll. 25.01.12 re LoulA- MS A vllli 04 Ray Austin n.y.it are C-- Louievilla Jones? 'h ! 28.1t.45 19.12.75 A* ]MuL 06.07.52 19.08.67 19.06.44 09.04.64 17.01.62 00.02.74 ictti 58 4J 52 45 ucc07 Charles 01.05.22 T Smart S Cherle- 27.08.44 iton 00.00.68 45 24 21 03.01.7J #, \ 14 1J 27.pf.71 (M0j|l < 28 28 19.12.71 f ^1* 20 4,5 07.01.68 20 09.04*64 12 fee. 12 24.07.75 S/4 24 17 2J.0J.68 Yes Yet Yes Yes Tel'S Yes Pot Cleaner (Keck 4MA 1974) p 51 Nlatory (Ivon tolling Stone In Amato NT Art ACAD SCIENCES Aef 1 NT Acad Vol 329 (1979) of Sc Syn> page 190 In 1974 Paper by Also Slock A Cott(no Of Jane 1,7,74 OSNA PSJ Pot Cleener (Cf Hock) Pot Ct*n*r (Cl Slock) loulavllla Courier Journal 02-09-80 Aef 1 Alao Slock JANA 1.7.74 P 51 Aef 1' Atao Slock Pot Cleaner (Cf (lock) Aef 1 Also Slock Pot CliMr (C( Slock) Aef 1 Alao Slock US Air Tore* Pot Clomor (Cf Hock) Aef 1 Loulavllla Tinea 2J.7.75 Attired April 1974 Alao Slock Aef 1 08 i _______________ i M.OJ.iO Goodyear Alager* 07.10.46 00.08.61 41 15 15 29.08.61 Yes i1 1 Aef 1 O o a D m 2 H > > O o o o o i.msis'sd 30 =* USA * Sheet LIVER Angiosarcoma Casas - (Review Data: February 1991) UK ayata* of dates DAY * MONTH * YEAR 1 2 3 4 5 8. 2 8 9 10 11 12 13 14 15 16 COUNTRY AND REFERENCE NO NAME 00 INITIALS DATE Of IRTN COMPANY FACTORT f09 RApaond 00.11.31 TO Loula- Settle* vllle fIngerl c 8 -<V^ FIRST VC EXPOSURE 28.03.45 DATE Of DIAGNOSIS 01.03.24 AGE A? DIAGNOSIS 43 YEARS Of EXPOSURE TO DIAGNOSIS 29 TEARS OF EXPOSURE DAtE OF BEAM 24 11.03.75 HISTOLOGICAL CONFIRMATION Yea ESTIMATED EXPOSURE LEVEL 2000 ppm OCCUPATION 0<>^v \P\ 1- 10 r 10.08.13 Goodyear Niagara 12.08.51 00.05.68 55 12 12 10,05.68 Ta* OTHER C4REER HIGHLIGHTS OTHER CWHEHTS Rtf 1 hat wrong figure* re flret expoture. loultvllle Timet 29.10.74, 12.3.75, 10.3.76 Ref 1 n 22.05.00 Goodyear Niagara 14.10.48 00.03.70 61 23 23 16.03.20 Yea Ref t 12 Francis A 12.11.18 FIreatone Pottttown 13.02.49 02.05.69 50 20 19 02.05.69 Yea Nigh 10 yra 10 yrg aa utility 1 Ref 1 * letter achwan Pa reactor op. Service op. of 26 April (not elaaner Nagger 1978 froai * aeparate Dryer op. Ruttell A Perk crew cleaned Stripping op. to J T SeeweII autoctavaa) 3 yra prior ol MCA aervlca In tyre plant IS Richard 01.12.21 ucc S Charle 11.12.42 00.05.24 52 32 26 07.04.74 Yea 2000 ppm Eduard ston Clendenln Cherleeton Billy Hell 21.7.75 CU) (15) 1 f Aever dlag* noted ae englotarcoaa of liver. 1nforaetlon given In letter 22 Hey 1984 from J A Selg. Accountant; ASL - No *vh denc* of VCM eapotur*. CONFIDENTIAL - A 000051 Efrszsi.s'sy 31. r US* Shett i UVEA Angiosarcoma Cases - (Aevlew Data: February 1991) UK System of dates DAY MOUTH YEAH t 2 3 4 56 7 8 9 10 11 12 13 14 15 16 countAT AND AEfEAENCE NO NAME ON INITIALS DATE Of SIA1H COMPANY fAC10AY 7 IASI VC EAPOSUAE DATE Of DIAGNOSIS m at DIAGNOSIS YEANS OF EXPOSUAE TO DIAGNOSIS YEANS 07 EXPOSUAE DA1E 07 DEATH HISTOLOGICAL CONFIXHATION ESTIMATED EXPOSUAE LEVEL OCCUPATION 01 HEN CAAEEA HIGHLIGHTS OTNEA COMMENTS 16 Janes 04.11.27 rc Howard Louis ville 08.05.50 00.00.69 41 19 04 27.03.69 Yea 4'Pt i3< '3 1951-4 VCM polymer isation From 1954 Table 4 In onwards In Wagoner Army and other Testimony to service. US Senate 46-50 Army Confirmed In M N Johnson Hr 07.08.78 /* > louls- Yes 17 Pe*r*nbocw 06,05.31 IFO vltte 23.06.55 11.10.7* 43 19 19 16.10.80 on 11.10.74 but no post-m>rtem 16.10.80 ij' Charlie Arthur 22.0*.28 >70 __ Avon take 15.09.54 00.00.75 46 21 13 02.11.75 Tea 13 yrt Navy autoeleaner 8 yrs on EstoL Tyre Store plaatlelaer 1 Carfcoset operation Or M N Johnson letter of 24.2.81 con firmed death 6 years after diagnosis Confirmed In M N Johnson Itr 07.08.78 Also Aottlng stone nag. 15.01.76 19 Virgil 00.00.15 ucc t Chart** 00.00.43 19.06.75 60 32 32 06.04.76 Yes 2000 ppm Christian tton 70 31.08.17 Goodyear Niagara 00.00.55 30.01.76 58 21 18 30.01.76 Yes Williamsport Sun Catette 21 June 1975 Charleston Dally Mall 21.7.75 NOISX letter of 23.10.79 21 Chester 02.09.09 UCC S Charle 00.12.46 Early 77 67 30 22 02.01.77 Ye* Hinkle ston U' L- 28 yrs with UCC at SC Aetlred News release 23.2.77 e^Qzsi.s'sy 32. USA - Sheet * LIVE* Angiosarcoma Casas (Review Data: February 1991) UK system of dates DAT - MODI* TEAK 1 1 3 4 56 7 8 9 10 11 12 13 14 13 16 count ST AND REFERENCE NO _rv y NAME ON INITIALS DATt Of IfttN 02.10.23 COWANT IEO FACTORY Louis ville first vc EXPOSURE 11.02.47 DATE Of DIAGNOSIS 00.01.76 AGE A! DIAGNOSIS 32 TEASS or EXPOSURE 10 DIAGNOSIS 29 TEARS Of EXPOSURE oate or 0EA1N HISTOLOGICAL CONFIRMATION 28 04.12.76 c. TCI ESTIMATED EXPOSURE LEVEL OCCUPATION VV, V, <2*> 00.00.23 Croat Fitchburg 00.09.38 06.04.73 50 13 14 06.04.73 American Mass. Chemical Company 0*1 ad 1990 by I Semett: Not angle arcema, but confirmed Cl olanglosarctxa 1 Yet OTHER CAREER HIGHLIGHTS OTHEH COMMENTS Loulavlll* Times 26.1.76 said he was the 10th AS victim at ells Lane of vhm 8 had died by 26.1.76 In his letter of 16.09,61 Or M N Johnscr ' confirms this Is th* cast describeby Dannaher Tamburro t Ta In Feb 1980 Ais l Medicine vol 70 p2B0 (25) 1 1Remo- ml fra* re* star coni rated In N i emlnskl let er of 3 Nov efcer 1960 _____________ ______________ ________________ R N Wheeler letter of 20/2/79 end Rose Kaminski tetters of 26/2/79 snd 3/11/80 CONFIDENTIAL - A 000053 t^8ZS L S'Sd 33. f LIVEIt Anqtosircm Cmm (Icvleu Date: Iebrunry 1991) UK system of dates DRV - MONTI- KU US* - Shoot 5 1 23 COUNTRY ANO REFERENCE NO NAME CM INITIALS DATE OF ININ h' ;\ John lorry 07.07.23 4 company F0 3 FACTONT loutsvltlo 67 FIRST VC EXPOSURE DATE OF DIAGNOSIS 03.10.47 00.00.77 (up to 2 yo*rs tftor death) 8 ACE AT DIAGNOSIS 52 (death) 9 TEARS Of EXPOSURE TO DIAGNOSIS 28 (death) 10 11 YEARS OF EXPOSURE DATE OF DEA1N 18 11.02.73 12 13 14 HISTOLOGICAL CONFIRMATION ESTIMATED EXPOSURE LEVEL OCCUPATION Ym Exposed In Various Jobs tona degree In PVC to 22 plants Eros chemicals cold room to but main exposure peett recovery to was to VOI, PVC charting probably operator to high pasta charging. HI August 1965. Terminated eaployment Jan 1966 15 OTHER CAREER HIGHLIGHTS 16 OTHER COMMENTS R Kaminski Utter of 26/2/79 and Prof. Tenturro tetter of 9/1/79 27 J L It.03.16 UCC Forrest t Chirle- 01.07.41 ston 30.11.78 62 37 20 25.11.78 Yet (NIOSN aaya 27 and C Dally Nall 23) Nigh Operator to 10.10.76 Exposure In R N Wheeler bulk and Itr of 4 Jan dispersion PVC 1979 and manufacture charleston Dally Mall 30.11.78 and R Kaminski 26/2/79 28 11.04.17 ucc S Chsrte- 00.08.44 03.11.78 61 34 33 03.11.78 Yet tton R Kaminski letter of 6/4/79 29 12.10.07 UCC S Chorlo 00.03,42 00.03,60 72 38 16 01.03.80 Yet ft on R RiiMnftH ur-- ' m* * t 5th Ho1* W6G SO WVN 22.07.22 Tennoeo Fleotlngtot 11.06.64 30.12.80 38 17 13 30.12.80 Yet 6 Unknown Maintenance Chemicals 9 - Minimal Mechanic 6 yrs Elsewhere 1* yrs loiter house Operator 9 yrs St'8Z9tS'SH 34 E * 1S 5= W CONFIDENTIAL - A 000055 USA - Sheet 6 1 j2 3 4 COUNTRY AM) REFERENCE NO NAME 0* INITIALS DATE Of ININ COMPANY ii 08.11.23 ucc UVEA Angiosarcoma Case* * (Review Date: February 1991) UK System of dates Day - Month Year 5 FAC10NY 6 FINS? VC EXPOSURE 12.03.46 7 DA1E Of DIAGNOSIS 01.08.81 8 AGE At DIAGNOSIS 37 9 VEAAS OF EXPOSURE 10 DIAGNOSIS 35 10 11 YEARS Of EXPOSURE DA1E OF 0EA1N 13 02.04.82 12 13 14 15 16 NIStOiOGICAl CONFIRMATION ES1IKA1ED EXPOSURE LEVEL OCCUPATION 01 HER CAREER nighligxts OTHER C0MMEX1S Yea Rlgh (Rut Chemical froM 1939 to Dr Docey not *( high Operator In 1976 At Iphetlc latter * rcictar chert* cltmtr reector Cheolcela 16.10.81 and operator and R N Wheeler would froa July 1976 letter of eaperlance) Worked ot to date Foreman 9.11.81. Also Dr Decay labourer Al 1 photic letter of Frit Jin* 1941 Chemical Operation 07.03.83 ro date of death. to May 1946 end My have cleaned reectort In that tlM 32 C U Cl row 22-02-08 Monsanto i prlngf Ul< 1 15-10*31 00-07-79 M*>t 71 28 14 17-03-80 An autopsy The death 1940-1951 (In PVC was done and certificate varlout Job* utoclAV* tamedlate flVt In polyaier area) cause of Mr Clroux' Manufacture death given ueual 8UTVAR as occigmtlon LUS1RER "Angiosarcoma" ae "kettle 1931-1964 operator" varlout job* In In and cheailceli crowd PVC Industry". autoclave! 1964-1973 Varloue clerical job* In PVC polysterleetl m Facility/ Retired 01-03-73. Information given In letter of 24 February 1982 from Dr waiter C earner of Monsanto Springfield to Dr A Mwn of Monsanto Europe. <33 S Ferguson 08-10-27 IFC loultvlll [ 00-09-54 11-05-82 34 28 28 AI1v Tea 1934-74 Multiple Jnr Nlfh lobe 1973-82 Including low Poly Operator Polycleaner. Prof TaMburro latter of 12 Aug 1982 * Dr M N Johnson letter of 28 Feb 1983. g^zst-S'SB 35 r Pege USA Sheet, ? LIVER Angiosarcoma Cases * (Review Data: February 199T) UK system of ditto DAT - MONTH * YEAR 1 2 3 A 56 7 89 10 IT 12 13 14 15 16 COUNTRY AMD REFERENCE NO NAME OR INITIALS DATE OF tIRTN CtMPANY FACtONt FIRST VC EXPOSURE YEARS OF DATE OF AGE AT EXPOSURE YEANS OF DIAGNOSIS DIAGNOSIS TO enposune DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTNEN caneen MtGHLIGNIS OTNEN COMMENT f 34 Hr tyfifi 29-01-34 to -r<?^ M ft < f-7 ax : l2ZJ 35 09-03-12 uec loullvllti 1955 03-11-82 48 'y v9 23-07-4^ $ Chsrte* ton 18-07-83 71 27 39 10 04.08.83 Yes 14 18-07-83 res 1053-74 Nigh 1975-82 low Poly Operator * Autoclave Cleaner 1055-65 1965 Left Or N N Johnaon (attar of 3 Nov 1082, BFG to 28 Feb 1083 and 0 Augutt 1984. become a Clergyman, High from 1944 to 1055. Had froai 1035-1058 Dr Dacey lattar of 5 Septeafcer 1083. 36 u.c. 22-08-32 the Genera Athtebula 11-04-36 21-08-83 Price lira and lubber Ca 50 27 27 Atlvo Yes Noderst* 1036-56 1abourer 1956-57 prod helper 1057*70 operator 1970-75 electrician 1975-83 operator N U lawidrla lattar of 12 Sept 1083: tpotttd at Medical May 1083. Tatting coataanced May 1983 toy l, Johnaon lattar* fab t March 1900 ' 1*7 J Payton 29.08.20 20 loultvllta 1933 06.08.84 54 31 22 06.08.84 Yes Nigh (forked regularly In PVC area In the early dayt vat a reactor cleaner 1953-75, Inforaatlon given In letter 00.08.84 froai Or N N Johnaon It JWfl 28.08.22 Air Products Calvart City 00.02.63 lOaOl.Bt 61 20 20 28.10.83 Yes Nigh Normal 1063-1082 progression from helper to senior operator, cleaned reactors, Stripping A recovery areas as tell as charging operator. throabo cytopenla and leukopenia Inca 1078. Gold traatment for arthritis 1076. Under Or.'a cara about 6 Month* before death, had patted tttndtrd phytlctl eiamlnetIon 3 auntht earlier. J. larr letter* of 22.10.84 and 23.01.85. <v CONFIDENTIAL - A 0 0 0 0 5 6 ^SISSH 36. US* Sheet 8 LIVE* Angiosarcoma Cases (Review Date: February 1791) UC system ol dates DAT - MONTS TEAS 1 A 56 7 s9 TO 11 12 13 u 13 16 COUNTRY AMD REftllENCE MO NAME OR INITIALS DAT! OF IIATN COMPANY FACIONY FIRST VC EXPOSURE 1 DATE OF AGE A? DIAGNOSIS DIAGNOSIS YEANS OF EXPOSURE TO DIAGNOSIS yeans OF EXPOSURE DATE OF DEATH HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE occupation ATION level OTHER CAREER HIGHLIGHTS OTHER CCMHENtS Never In hsepltel For any chronic or 39 J Nntict 2T.06.1A Pantasota Passaic 19AO March 63 2* 23 29.06.8A Ye* Lou 29.09.60 Worked acuta medical problems. Death certificate 1964 May 66 beFora stateg causa of desth csrdlo-putmonary Vinyl 1960 srrest secondsry to sngloesrcoma of Fabrication with US liver. Nish Plant May 66 - Alt Fores, latter of 15.07.86 from John E Ertsl of Psntssoto with (attar of 2*.02.86 Aug 70 United from Dr Auerbach, Pathologlat. Utility Wool Kesln Dyers Operator snd (Inc Jut 66 OkenltS - Sep 67 Reactor Operator) low Sep 70-82 Monomer Operator low 1982-83 Mill Operator, Calendar Shop, until retirement AO P P 26.10.1* IFO Gilmer loutsvide 22.03.A2 1902 72 A3 3A 03.01.87 Ye* 8l|tl Chemical 19A2-197A Worker 19A2-A3 low 1973-1976 Foremen 19*3-76 latter from Dr Diets, IFO, 10.3.87 41 A Buckle' ' 2.02.13 Goodytir si agara I9A9 Falls 1987 72 38 27 20.08.87 Ye* Nigh 19*9-63 Set 1 red Lattara from Prof Taafcurro Chemical Op 1977 University of Loulsvllla, 1987 Shift Sig>/ (Age 62) and Dr C A Johnson, Goodyear, 1988 Foreman, PVC Aeeln Prockjctlon Medlus 1965-77 NF Plant tied PVC area For 6 nnths In T 631 ...... ............-I ___________ CONFIDENTIAL - A 000057 8V8AStS18U 37 USA Sheet_9 LIVER LntlosircgM Chm - (Review Date: February 1991) UK aystea: of date* OAT - MOMTM TEAR ------------;------------ 2 3 ( 3 7 89 to 11 12 13 14 13 18 country and REFERENCE HO name oh INITIALS DMt OF 1RTH COMPANY FACTORT FIRST VC EXPOSURE YEANS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS 10 EXPOSURE DIAGNOSIS DATE OF DEATH HISTO LOGICAL ESTIMATED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTHER CAREER HIGHLIGHTS OTHER COfMEMTS 42 NcHullcn 02.03.(1 01 In Astonet 00.04.68 00.M.B2 41 14 6 09.07.82 Tea Nlh labourer In Pot area: pot deanou regularly Letter frem Or Peter Namltl 13.04.89 A3 J H 08.09.21 Gertorp Ashtabula 14.04.33 26.11.88 67 Sued (formerly Ohio General Tire) 33 28 10.01.89 Tea PVC Resin Retired Plant: 01.01.84 letters frem Roy Johnson, GenCorp 08.03.89 and 30.03.89 *l*h Maintenance Cleaner 1.6 years Shift Hedlue Mechanic 2 years Plant Lou Electrician 24.10 years CONFIDENTIAL - A 000058 6t'8iSl-S18H 38. YUGOSLAVIA -- l IVYA Angiosarcoma Cases - (Review bate February 1991) 1 2 3 4 56 7 09 10 11 12 13 14 15 counter and REFERENCE NO NAME 0* IHI11ALS DATE OF ININ COMPANY YEARS OF FIRS1 VC OAYE OF AGE AT EXPOSURE YEARS OF FACIORY EXPOSURE DIAGNOSIS DIAGNOSIS 10 EXPOSURE DIAGNOSIS DA1E OF OEAYN HISTO LOGICAL ES1IMA1ED CONFIRM EXPOSURE OCCUPATION ATION LEVEL OTNER career HIGHLIGHTS 16 OTNER CONTENTS YUGOSLAVIA 01 OS.04.14 JUgo Vlntt Split 00,00.53 00.04.73 59 20 20 00.04.73 m SARIC *1 At piper Env Health Perspective Vol 17. pp 109-192 1976 !! 0? 1J.11.31 Split 00.00.50 12.07.73 42 23 10 12.07.7J Yes* VCN Production In hie letter ef 3 Oct 1978, Or Splrte* ef NIOSN changed the itetui of Case-02 to VCN production eapteyee. Dr Splrtas alio notified a new Case 03 also a VCN production worker. 0J 21.12.31 Jugo Spilt 04.06.54 11.01.76 45 22 22 11.01.76 t* VC* Vlnll Production OA 11.06.30 Jugo Split tJ.12,50 03.09.70 40 20 10 ' 03.09.70 Tt* Vlntt Rose Xaalmkl letter oF 19 June 1900 ind IARC letter of 1 April 1902 O O z mo z -I > > oo o osezsissa 39. I Incidence of ASl Cases Per Aim - By Date of Death TABLE 1 1955 6 7 8 9 1960 1 2 3 A a 9 1970 1 2 3 A 5 6 T 8 9 1980 1 2 3 A 5 6 7 8 9 ................................. 1 ................................. 0 ................................. 1 ........................................ 0 ........................................ 0 ........................................0 ........................................ 1 ........................................ 1 ........................................ 0 ........................................ 2 ................................. 0 ........................................0 ................................. 1 ................................. 5 .................................... 3 ........................................ 2 ....................................3 .................................... 5 ........................... 8 ................................. 3 ................................. 11 ................................. 11 ..................... 8 ................................. 10 ................................. 5 ................................. 10 ....................................5 ................................. 3 ................................. 10 ........................... 8 ......................8 ................................. 11 ................................. 3 ................................. 7 ................................. 5 Total 153 (Review Date - February 1991) NOTES T Does not Include Italian 01. 2 The 1977 total now excludes US2A, Choi angiosarcoma: deleted. 3 The 1982 total now excludes 628 Alcoholic Cirrhosis; deleted. A Does not Include the following who are still alive, so far as known; FrIS and 28, US33 and 36. CONFIDENTIAL - A 000060 IS9,'SIS'8H 40. TABLE 2 (Review Date - February 1991) Distribution of ASl Cases bv Country (these ere listed In descending order of nuifeer of cases.) USA II Germany France UK Canada Sweden Italy Yugoslavia Japan Czechoslovakia Belgium Norway Spain Australia Total 39 t *** 38 ***** 28 ** 16 13 5 *** 8* 4 **** 3 2 2 1 1 161 * emit itOI - atypical case of PVC bag extruder. ** includes Fr15 and 28, US33 t 36, Who are still alive, so far as known. ** Includes one monomer worker. *** Includes two monomer workers. ***** Excludes G26 and US 24; deleted. CONFIDENTIAL - A 000061 ZS8ZSISVU 41. \ \ (Review Dete February 1991) TABLE 3 Pattern of ASl Cases by Factory () M Europe Of the 99 cases In W Europe, 80 have occurred In clusters at 10 factories. Of the 38 German cases, 34 have occurred In clusters at 4 factories. ASL Cases Dynamlt (now Huls), Trolsdorf, Germany BP, Barry, UK Atochem (formerly Chios Chlmle, formerly RP), St Fons, France Wacker, Burghausen, Germany Atochem (formerly PCUK) Brlgnoud, France Kemanord, Sundsvall, Sweden ICI, Hllthouse, UK Solvay, Tavaux, France CUH/Huta, Marl, Germany Lonza, Ualdshut, Germany 19 11 11 10 8 5 5 3 3 3 80 NB: There are 32 pre 1962 PVC plants In W Europe; 20 of these have had ASL cases (Ref Table 8) (b) N America Of the 52 cases In N America, 41 have occurred at four factories out of a total of 55 factories. In N America 41 plants have not had ASL cases. ASL Cases BFG, Louisville, US BFG, Shawinlgan, Canada UCC, S Charleston, US Goodyear, Niagara Falls, US 15 12 9 _5 41 NB: There are 29 pre 1962 PVC plants In N America; 13 of these have had ASL cases (Aef Tables 9 t 10) (c) Rest of World Nine of the cases are believed to be In one cluster of 4 and two clusters of 2 casls. Australia 1 9 10 . CONFIDENTIAL - A 0 0 0 0 6 2 essiSLSW 42. tRevlew Oat* February 1991) TABLE 4A patency Period* lYeers from first Exposure to Diagnosis) Country No of Cases >tal Years Average U Europe Belgium France Germany Italy 2 35 17.50 28 795 28.39 38 783 20.61 * 8 172 21.50 Norway Spain Sweden 1 22 22.00 1 25 25.00 3 122 24.50 UK 16 96 H America US Canada 39 a 52 Rest of Uortd Australia 1 Czechoslovakia 2 Japan 3 Sunaary Yugoslavia U Europe i IS 96 N America 52 Rest of World 10 M * Of the countrlea with > 10 cases, France, USA t Canada below world average. 376 2267 23.50 23.61 U Europe Average 1002 25.69 * m 1316 24.15 * 25.30 R America Average 25 25.00 30 15.00 59 19.64 85 21.20 199 20.00 Real of World Average 2267 23.61 1316 25.30 199 3845 20.00 23.88 * World Average an average latency period above world average; Germany t UK CONFIDENTIAL - A 000063 t'SQZSIS'&H 43. DISTRIBUTION OF LATENCY PERICOS TABLE 4B (Review Date - February 1991) 0-9 yrs 10*14 yrs 15-19 yrs 20-24 yrs 25-29 yrs 10-34 yrs 35+ yrs Australia Belgium Canada Czechoslovakia France Germany Italy Japan Norway Spain Sweden UK USA Yugoslavia 1 1 1 2 3 52 11 1 4. 3 10 5 12 10 6 1 223 12 1 1 22 516 3 79S 4 12 46 4 1 3 66 Total 1 2 13 2 28 38 8 3 1 1 5 16 39 4 Average Latency Period (Table 4A) 25.00 17.50 24.15 15.00 28.39 20.61 21.50 19.66 22.00 25.00 24.50 23.50 25.69 21.20 TOTAL 2 14 ' 36 . 37 39 19 14 161 23.88 CONFIDENTIAL - A 000064 SSBZSISVU 44. TABLE 4C (Review date February 1991) LATENCY PER ICO Of ASL CASES TABULATED BT TEAR OF FIRST EXPOSURE MAX POSSIBLE LATENCY PERIOD 51 49 40 4/ YEAR OF F1R9IPQSURE 1939 1940 41 42 46 43 44 45 46 42 47 41 40 49 1950 51 37 52 36 53 54 55 56 57 32 31 50 59 1960 61 27 62 26 63 64 65 66 22 67 21 60 69 1970 71 17 72 16 73 74 TOTAL LATENCY PER 100 (NO OF YEARS) ARITHMETIC MEAN OF LATENCY PERIODS 37,21,37,41 32,30.45.47** 30,14,32,42,45 20,11,24,20,24,34,39,44 27,22,20,29,37 21,29,31,26,20,15,23,30,35 29,24,29,20 20,24,34 30,26,20,30 26,22,31,19,23,14,33 19,20,17,20,34,29 21*.15 25,23,22,20,31.22,32,30,23 21,21,25,25,21,20**, 22,34,34 22,23,24,14,19,21,27 27**,24,20,30,33 21.12,27**,32,29 19,17,15,13,16,20,30 290 37.25 0 006 * 20.50 31 559 25.41 22 1010 - 24.04 42 10,10.15.17,20,29,20, 16,21,25,27 13,10,21,25,24,25 15,16,16,16,19,19,12,20 13,10,17,12.10,21,26 16,17,20,21,25,25,26 16,17,25 11,19,20 9.10.21 16 10,5,10,14,19 13,16 13 161 CASES 626 - 19.56 32 347 19.23 10 114 1*.50 0 3046 - 23.09 161 1 VIOLA HAITONI GOODRICH CONFIDENTIAL - A 000065 * Aerosol can filler G 03. ** The following are still alive, so far as known Fr IS and 20, US 33 and 36 45 9sa'.si-sisa (Review date February 1991) TABLE AO LATENCY PERI QOS OF ASL CASES TABULATED BT TERR OF FIRST EXPOSURE AMD GEOGRAPHICAL ioc*tlow MAX POSSIBLE IA1EMCT PERIOD TEAR OF FIRS! EXPOSURE LATE* CT PERIODS IN WESTERN EUROPE NORTH AMERIO ROW 51 1939 49 1940 48 1 37,41 21,37 47 2 47" 32,38,45 46 3 38,45 14,32.42 4 28,44 11,24,20.24.34,39 5 27 22,28.29,37 6 21,29,31,33 26,28,15.23.30,35 42 7 29 24,29.28 841 28,34 24 9 30.26 20,38 1950 26,22,31 19 1 19,28,34,29, 17,28 37 2 21* . 15 23,14 36 3 25,22,32,30,23 23,31 22,20 4 21,21,25,25,34,34 21,28** 22 5 22,23,24,27**24,28 14.19,21,27 30 6 21,12,32,29 27** 32 7 19,17,15,13,28 30 16 831 18,18,29,28 15 9 16,21,25,27, 1960 13,18,21,25,25 24 1 15,16,16,16,19,19,21 12 27 2 13,18,17,18,21,26 12 17,20 26 3 16,17,21,25,25,26 20 4 16,25 17 5 11,19 6 9,18.21 22 7 16 a21 18,5,18,19 14 9 13,16 20,25 VIOIA 1970 1 2) 17 MAUOMI 3 TOTAL OSES 99 52 10 CONFIDENTIAL - A 0 0 0 0 6 4 * Aerosol can filler G 03. ** the following are atIIl alive, to far as known Fr15 and 28, US33 and 36. 46. V9?8TS'9H PLANT TROISTORF U GERMANY LOUISVILLE USA SHAU1NIGAN CANADA BARRY UK ST TONS FRANCE BURGHAUSEN U GERMANY START UP DATE 1954 19407 1943 (19417) 1948 1939 1933 TABLE 4 E (Review Date February 1991) LATENCY PERIOOS OF ASL CASES IN SPECIFIC PLANTS (10 OR MORE CASES) 12,13,16,16,18,19,19,21,23,25.28.29,29, 5,23,16,34,18 12,14,15,19,19,20,24,27,28,28,28.29,29, 31,45 11,12,14,21,22,23,24,24,26,28,42,37 NO OF CASES 18 15 12 AVERAGE LATENCY PERIOD 20.22 24.53 23.66 9,17,18,28,31,33,18,19,18,21,32 11 22.18 21,28,29,37,38,27,41,34,44,34,47 11 34.53 17,21,22,25,24,13,21,32,30,30 10 23.50 ..................... 1 CONFIDENTIAL - A 000065 7.98481-SSU 47. (Review date February 1991) TABLE 4F LATENCY PERIOD OF ASL CASES TABULATED BY TEAR OF FIRST EXPOSURE AND SPECIFIC PLANT <10 OR HORE CASES) YEAR OF FIRST EXPOSURE TROISDORF LOUISVILLE SHAUINIGAN U GERMANY USA CANADA BARRY UK ST FONS BURGHAUSEN FRANCE W GERMANY 1939 1940 1 2 3 4 5 6 7 21 20 20,29,27 29,28 14,42 11,24 22,37 26,28 24 37,41 47 38 44 29 B 9 1950 1 2 29 24 19 15 31,33 2B 28,34 3 23 31 23 25,32,30 4 21,25,34 28 34 21 5 23,28 14,19 27 22,24,30 & 12,29 32 21 7 13 17 B 9 1960 1 16,16,19,19 12 2 18 12 18 21 3 4 S & 7 a 9 1970 1 2 5,18,19 16 17 19 9,18,21 18 13 CONFIDENTIAL - A 000066 ssazsissa 48. (Review date February 1991) TABLE *0 PLANT START-UP DATE LATENCY PER 100 OF ASL CASES NO OF IN SPECIFIC PLANTS(4~9 CASES) CASES AVERAGE PER 100 S CHARLESTON USE 1939? 24,30,32,32,34,35,37,38,39 9 301 33.44 9 BRIGNOUD FRANCE 1950 11,16,18,26,30,25,34,45 8 25.62 SUNDSVALL SWEDEN 1945 16,19,27,29,31 5 24.4 NIAGARA FALL USA 1947 15,17,21,23,38 5 22.8 TAVAUX FRANCE 1953 19,16,21,26,25 (le FR26) 5 107 - 21.4 5 MIllHOUSE UK 1940 28,25,28,25,26 (le UK17) 5 132 - 26.4 5 SPLIT YUGOSLAVIA 1950 20,20,22,23 4 21.25 CONFIDENTIAL - A 000067 esezsissu 49 (Review date February 1991) TABLE AH LATENCY PERIOD OF ASl CASES TABULATED BT TEAR OF FIRST EXPOSURE AMD SPECIFIC PLANT <4-9 CASES) YEAR OF S CHARLESTON BRIGNOUO FIRST EXPOSURE USA FRANCE SUNDSVALL SWEDEN NIAGARA FALLS USA TAVAUX FRANCE HILLHOUSE SPLIT UK YUGOSLAVIA 1939 1960 1 2 3 4 5 6 7 37 32,38 32 24,34,39 30,35 45 27* 31 15,23 29 28 8 9 1950 1 2 26,30 34 19 38 17 23* 3 4 5 6 7 B 9 1960 1 2 3 4 5 6 7 18 16,25 16 11 25 21 19 28 20 22* 20 26 16,21,25 25,26 8 9 1970 1 2 `Monomer worker CONFIDENTIAL - A 0 0 0 0 6 8 098ZSLSSB 50. TABLE 5 (Review Date - February 1991) Annual Incidence of ASt Cases (Pate of Death) by Geographical Area Western Europe North America Rest of World Annual Total Cunulative Total Key Events 1955 7 1961 2 4 7 B 9 1970 1 2 3 4 5 6 7 8 9 1980 1 2 3 4 5 6 7 8 9 1990 1 1 1 1 1 1 5 12 11 12 41 14 32 66 63 62 72 5 64 5 3 73 62 7 10 1 3 8 6i 1 1 1 1 12 1 5 3 2 3 5 38 5 1 11 2 11 8 1 10 5 10 5 3 10 8 18 11 3 7 5 1 1 2 3 4 6 7 12 15 17 20 25 33 38 49 60 68 78 83 93 _____ 98 101 111 119 127 13B Ul 148 153 Viola Haitonl Goodrich TOTAL__________ | 97* ** j 50** | 10 | 153_____________ |_______________ ^ * Omits It 01 bag extruder * Does not Include the following who ere still alive, so far as known: FrIS and ZB, US33 t 36 NOTE: G26 and US24 deleted. CONFIDENTIAL - A 000069 t98ZSLS$d 51. TABLE6 (Review Due February 1991) ASL CASE NUMBERS BY YEAR OF DEATH AND GEOGRAPHICAL LOCATIONS (EXCLUDING IlOD KEY EVENTS 1955 6 7 S 9 1960 2 3 4 5 6 7 t 9 WESTERN EUROPE FI Cl Viola 1970 Swl Mahoai Goodrich 1 2 3 4 G2 Nl,Sw2,UKlJk2 G3* G4,G5,UK3 5 6 7 S 9 1980 1 2 3 4 5 6 7 > 9 1990 F2JP3 ,C6,C7,CSJt3 BI.F4,FS,F6,F7,Sw3 F*,F9,GI0,GIl,CI2w4 F10,F11.G9,G13.GI5 G16.G17 F13LF13,UK4,UK5,GIS UK6,UT7,G19,SwS,G20,G2I MF14,UK>,G22,G23 UK094tJJ1732,G24,G25,G30 UK10,F16,Flt,G27,G29lG35 UK11 ,UKlLF19rF20,G2S,G33. G34 F21.UU3 J87.G3I .G32, G36,G37,G38,G39 F25.F26, UKJ 4, UK15.UKJ 6,G40 F22J=23,F24,F27.Spl,UK17, 1M9 TOTAL i" ;wr............... 97** ** Doc Dot include the following wbo arc atin alive, an far aa knows: F15 and 28, US33 and 36 NOTE: G26 and US24 deleted NORTH AMERICA Cl C2 US1 C3 US5 C4.C5 .US4.US7.US 10 U312.US16 US 11 C6.US2 C7 C*,US1,US3,US23 C9.US13 US6,US9,US 1 S.US26 U519.US20.US22, C10.US21 US27.US2S USI7.US29.US30.US32 - US31.US42.C12 US3S.US34.US3S US37.US39 Cll US40.US41.C13 USO 50* REST OF WORLD Ce2 Yl.Y2.Gcl Japl Jap2.Y3 Y4 Jap3 AnaOl 10 R&S157862 52. CONFIDENTIAL - A 000070 CONFIDENTIAL - A 000071 TABLE 7 (Review date February 1991) ASL CASE NUMBERS BY TEAR OF FIRST EXPOSURE AMO GEOGRAPHICAL LOCATION (EXCLUDING It.01) KEY EVENTS WESTERN EUROPE NORTH AMERICA REST OF WORLD 1939 40 1 2 3 4 5 6 7 8 9 50 1 2 3 4 5 6 7 8 9 60 1 2 3 4 5 6 7 8 9 Fr11,Fr16 Fr28** Fr14,Fr24 UKl,Fr23 Su2 Fr1,Fr3,Sw4 Su3 Fr9, Fr17 Fr12,Fr4 Fr7,N1,UK8,UK9 Sw1,UK5,fr20,G30 G3 G15,lt3,G31,G33,G36 G7,G8,G19,G3B,Fr27,UK4 G11.G16.G18, FrlS** G23,G28,G32 FR10,G1,G34,UK15 Fr8,G4,It2.G2,UK12 Fr6,B1,Fr22,lt7 Fr2,lt4,Fr19,Fr21 G5,G13,G25.G28,lt6 G9,G10,G12,G17,G20,G22 It.08, G6,UK6,G21,B2,G29,Fr2S Fr13, UK7,Fr18,UK16, UK17,Fr26 Su5,Sp1 Fr5,UK11 UK3, UK10,UK14 It5 UK13,G35,G39 G24.G37 C3.US27 US13, US29.US40 C2,US19,C11 Cl,C5,US5,US7,US28,US35 C4,US3,US9,C12 C7,C9,USB,US11,U$21,US31 C6,US22,US26 US1 US12.US41 US 16 T2, Ct2 US10, US32 US4 CIO, US37 Japl.VI US18.US33** Y3 US2,US17,US20,US34,US43 US36** C13 US23 Cil Jap2,T4 US39 C8 US6 US38 US30 Jap3 Aus 01 US42 Viola 70 1 2 It 09 Maltonl 3 Total 99 52 10 * Aerosol can filler (G3) ** FrlS, Fr28, US33 1 36 are atill alive, *o far as known 53 eOTZSlSW CONFIDENTIAL - A 0 0 0 0 7 2 STMT-UP TEM 1931 1933 1938 1939 WO 1945 1946 1948 1949 1950 1951 1952 1953 1954 COUNTRY MME West Gerwnrry Meet Genaony Italy France United ttngda United Kingdon Sweden France United Kiwloa West Scrawny Belgiua France France Holland Norway Switzerland Italy Italy Austria France Italy Spain United Klngdon West Gerweny West Gerwany 1955 Spain COMPANY NAME BASF Wacker Montecatini Rhone-Poulenc/ Chloe/Atocheve ICl/EVC ICI/EVC Kesnoord/Nobel Rhone-Poulenc BP Chen/ICI/EVC CUH/Hula Solvay PCUK/Atochew Rhone-Poulenc/ Chlow/Atochea Shell Norsk Lonza/ICI/EVC Montedison/ Noplefan Nontedison/EVC Halvic/Solvay Solvay Solvay Rio Rodano BXL/BIPTNORSK Noechst Dynanit/Huis (since 1.1.89) Monsanto Iberia t798Z9LS'SU TUPLE 8 LOCATION Lixfctgshafen Burdiausot Acna St Fons Rmcom (closed 1948) Hillhouse Sendsva It (Stockylk) Roussillon (Closed 1-1-87) Barry Karl Jeawppe Brlgnoud St Alban Pemis, Rotterdam Heroya. Porsqrtan Sins Terni Porto Manfiera Hallein Tavaux Ferrara Nemani Ayctiffe Gendorf Troisdorf Mon/on Torrelavega 54. W ^------ 1 *' y,f......... ASL CASE NUMBER Ievlev Date February 1991 YEAR OF 1ST EXPOSURE 04,07,11,15.23,24 25.31.32.33 57,54.55.53,55,69,60,53 55,53 03.09,10,11,14 15.16.17,23.27.28 01.04.12.16.17 01.02.03,04,05 01 03.05.06,07,08,09 10.11,13,14.15 09.10,29 01,02 02,04,05,06,12,19 20,24 07,22 01 46.48,56,41,43, 55,41,48,44,54,42 44,54,57,63,65 51,45,47,46,64 46 66,51,62,63,50,50' 66,65,68,66,56 61.61.62 58.62 59,49,65,58,49,59. 51,43 50,58 50 07 02,06 08,13,18,25,26 03 18 01,02.08,12,16,17 19,20.21.22,27,30 34,35.36,37.38,39 58 57.60 57,63,63,62,63 53 55 56,57,54,61,55,61, 54,61,62,61,55,51 56,68,53,69,54.68 START-UP YEAR COUNTRY NAME TABLE B UESTEBM EUROPE PVC PRODUCERS - START-UP DATES VS ASL CASES (CHITTING G03. It OB, It 09) COMPANY NAME LOCATION ASL CASE NUMBER 1956 1958 1960 1961 1965 1966 1967 1968 1969 1970 1971 1972 1976 1977 1982 Spain West Germany Italy West Germany Portugal France Italy Italy West Germany West Germany France Spain Greece Belgitai united Elngdoa Italy Italy united Kingdom Spain Sweden United Kingdom Finland Holland France Spain West Germany Calgsa Nispavic/Solvay Solvay ANIC/SC Ravenna EVE Lwua/ICI/EVC Cires Rhone-Poulenc Pozzi Pensac Wacker Hoechst Atochem Rio Rodano Esso Pappas Badiphil Vlnatex/Norsk Rtaaanica/EVC SIR ICI/EVC Nispavic/Solvay Xemanord/Morsk BP Chem Pekesm OSM Soc Art D'vinyl (CDF) Monsanto Iberia ICI/EVC * Laboratory Worker in Research Department Rheirberg Ravema Waldshut Oporto Nantlucon Ferrandina Mira,Venice Cologne Knapsack(Frankfurt) Balan Miranda de Ebro Oiavata Salonika Antwerp Staveley Cagliari Sardina Porto Torres Sar RtsKom Martorell Stenmgsmd BagIan Bay Svartback Berk Lisburg Mazingarbe Tarragona Voslapp WiIhelashaven 01 04 06.13.28 21 05 05* Review Date February 1991 TEAR OF 1ST EXPOSURE 64 5? 62.60,60 59 67 60 CONFIDENTIAL - A 000073 S98Z91S1SB 55. (Review date February 1991) TABLE 9 USA PVC PRODUCERS - START-UP DATES vs ASL CASES rT -j 1--- -|---------------------------- 1 |START-UP | COMPANY NAME | LOCATION | ASL CASE | YEAR OF | | YEAR 1 1 1 NUMBER 1 1st EXPOSURE | 1 1939? |*UCC | S Charleston (07,13.19,21,27 144,42,43,46,41 | , I1 1 128.29.31.35 144.42.46.44 | 1 | Dow | Midland (made | 1 1 I1 1 Saran conolvmer) 1 1 1 1 1940? | *BFG | Louisville 101,02,03,04,05, 148,55,45,52.44, | 1 I | 106,09,16,17,22, 162,45,50,55.47, | 1 I 1 126.33.34.37.40 147.54.55.53.42 1 I 1946 l*UCC/Dow 1 Texas CltY (Partially closed 1977) 1 1 I __L942-- 1 Goodyear------ 1 Niagara Falls 108.10.11.20.41 146.51.46.55.49 1 1 1948 | Firestone/ | Pottstown |12 149 | | 1 Occidental 1 11 1 1 | Unlroyal I1 | Painesville 1 (closed 1975) | 1 1 1 1 1 1 1950 | Monsanto | Springfield |32 151 | I1 1 (Closed 1975 1 1 1 1 1952 1 Dow 1 Midland (No PVC since c 1975) 1 1 1 1 BFG 1 Avon Lake 118 154 1 1 1953 1 Diamond/BFG 1 Deer Park 1 1 1 1 1954 | General Tire/ ** I Ashtabula 136,43 156,55 1 1 1 PlversiTech 1(Closed 1983. Reopened 1986 by Vygen) 1 1 1956 1 Air Products 1 Pensacola (Pace) I 1 1 1 1 Atlantic Refining 1 Brooklvn(Closed late 1960s) 1 1 1 1 Borden . 1 Leominster (Closed 1984) 1 1 1 1 Conoco 1 Hebronville (Closed 1975) 1 1 BFG 1 Niagara 1 1 1 | Great American | Fitchburg 123 158 | I 1 Plastics 1 (Closed 1983) 1 1 1 I 1 Hooker 1 Hicksvllle (Closed 1980-81) oI 1 Pantasote 1 Passaic(Closed 1984) 39 z I 1957 1 Atlantic Tublne 1 Cranston (Closed 1967) 1 160 1 1 1 11 Zma 1 1 | Tenneco/ 1 Occidental | Flemington NJ 1 (Closed 1985) |30 1 159 1 | 1 > I 1958 1 Kevsor Century 1 Saugus. Cal 1 1 1 > *o-ooJ 1 11 | Air Products 1 | Calvert City(Paducah) 38 163 1 (Closed March 1982 Re-ooened October 1983) i Continued jg 1 1 1 ! 1 TABLE 9 (Continued) USA PVC PRODUCERS - START-UP DATES vs ASL CASES r- ' '1---- -------------- 1 |START-UP | COMPANY NAME LOCATION | ASL CASE | YEAR OF 1 YEAR 1 NUMBER 1 1st EXPOSURE 1960 | BFG Long Beach, Cal (No PVC now. Formerly shown as Uatson) 1 1 1962 1963 1 Borden lllloDolls 1 Tenneco/Occldental Burlineton NJ 1 Conoco/Vista Aberdeen. Miss 11 11 1 .....................,, 1 1 Stauffer 1965 | Conoco/Olin Lone Beach. Cal (Closed 1982) Assonet, Mass 1 *2 1 168 (Closed bv Olln 1975) 1 1 Ethvl ...... Baton Rouee (Closed 1984) J 1966 | Diamond/Georgia 1 Gulf ... Delaware City 1 1 1 1 IGen Tlre/Pantasote Mt Pleasant W Va 1(Closed 1982) 1 1 BFG Henrv. Ill 1______________________ _1 1 Stauffer/Formosa Delaware Cltv (Sold to Formosa 1981) 1967 | Allled/Roblntech/ Palnesvllle, 0. (No PVC made by Roblntech. 1 Georela Pacific GP converted to oolvstvrene) 1 1 Hooker/Occldental Burlineton NJ 1________________ 1 1968 1 Firestone/Occidental Perrwllle (Closed 1982) 1 CONFIDENTIAL - A 000075 1969 1971 1972 1973 1974 1975 1979 1983 1986 1 BFG Pedrlcktown NJ 1 1 1 Goodvear/BFG Plaauemlne 1 _l 1 Conoco/Vista Oklahoma City I 1 1 Nat Starch Meredosia. Ill 1 1 1 Borden Sorlnefleld______ 1______________________ 1 | Atlantic Tubing/ Crans.ton RI (Closed 1982) 1 1 Tallvrand I1 1 Shlntech FreeDort. Tex 1 1 1 Certain-teed Lake Charles 1 1 | Georgia Pacific/ Plaquemlne, La 1 1 1 Georela Gulf . 1 .... 1 1 Tenneco/Occldental Pasadena. Tex _!_______________ J | Firestone/ Addis (formerly shown as 1 1 Occidental Plaauemlne) 1______________________ 1 Formosa Point Comfort. Texl 1 1 Vveen I ** 1 Ashtabula. Ohio 1 1__________________ ___ __ _____ 11_________________________ l .................. -........ ..... * My databank has^ no Information on UCC before 1946 or BFG before 1950NB ** Refer to same plant at Ashtabula, bought by Vygen from DlverslTech. Some of the plants In this list were closed down, some have changed ownership over the years, some have changed their product. Z98ZSI-S1Stl (Review date February 1991) TABLE 10 CANADIAN PVC PRODUCERS - START-UP DATES vs ASL CASES i--------------------------- r-........... ....... ...............-- i ------------------------------------------- }------------------------------------------------- j------------------------------------------------i START-UP| COMPANY NAME LOCATION ASL CASE YEAR OF YEAR | .... t|_......................... ............... - _______j NUMBER 1st EXPOSURE 1943 | Goodrich Shawlnlgan 01,02,03,06,05 44,43,41,45,66, (19417) | (Formerly Gulf) 06,07,08,09,10, 47,46,61,46,53 | (Formerly Shawlnlgan (Chemicals) 11,12 43,45 j (Formerly Canadian Res;lns & Chemicals) |---------------- 1 ------------- 1------------------------------------- 1 1 1951 | Monsanto < ........................ 1 | La Salle (Closed 1<>75) i 1 ............. ............ .......----------------------------------------------------------------------------- 1957 Goodrich Welland (Niagara) 13 57 1966 Esso (Imperial Oil) Sarnia 1979 Diamond Shamrock Alb/ Fort Saskatchewan BF Goodrich CONFIDENTIAL - A 0 0 0 0 7 6 SSBZStSSH 58. (Review date February 1991) TABLE 11 EASTERN BLOC PVC FACTORIES - START-UP DATES vs ASL CASES r* 1--- _7------- ----'--" "T I START-UP | COUNTRY NAME | COMPANY NAME | LOCATION 1---------------------- --i----- | ASL CASE | YEAR OF YEAR i 1 i 1 NUMBER 1 1st ExDosure iPre 1939 1 East Germany 1 State Comoanv 1Schooau 1 1941 IRussia 1 State ComDS iVladimlr et al 1 1 1950 lYugoslavia IJueo Vlnll ISDllt 101.02.03.04 153.50.54,58 1951 1 Czechoslovak! a 1 State Comos 1Novakv 101.02 157.50 1955 I East Germany 1 State Comos iBltterfeldt 1 1 1956 1 Rumania 1 State ComDS 1Icechlm 1 1 1957 1 Poland 1 State Comos lOswelclm (Dworvl 1 1 |Rumania 1 |State Comps 1 |Tirnavenl ITurda 1 1 1 _J 1958 1 Rumania 1 State Comos iRlsnov 1 1 1959 1 Hungary 1 State Comos IBerente Borsod 1 1 1961 1 Rumania 1 State Comos IBorzestl 1 1 1963 lYugoslavia lOhls ISkoDle 1 1 1965 1 Bulgaria 1 State Comos 1 Varna 1 1 1967 1 Poland 1 State Comos ITarnow 1 1 1969 IRussia 1 State ComDS IDlerlinsk 1 l 1970 1 Rumania IRussia 1 State ComDS 1 State ComDS ..IRimnlcu Vilcea .1 Volgograd 1 1 1 _J 1972 1 Yugoslavia IVlnilDlastika 1 Zadar 1 1 1975 1 Czechoslovak! a 1 State ComDS IRussia . __ 1 State ComDS INeratovlce IKalush Area 1 1 1 _J 1976 1 Yugoslavia IHId iPancevo 1 1 1977 1 Rumania_______ 1 State ComDS IRlmnlcu Vilcea_____ J____________ ____ 1____________________________ 1i------------------------------------------------------------- 1----------------------------------------- 1--------------------------------------------------- 1---------------------------------------- 1------------------------------------------- i CONFIDENTIAL - A 000077 eggzsi.s'sa 59. (Review dale Fidiniaty 1991) TABLE 12 1APANESE PVC PRODUCERS - START UP DATES VS ASL CASES R&S 157870 34 Factories ofwhich I an closed -Total 36 60 CONFIDENTIAL - A 000078 (Review date February 1991) TABLE 13 SOUTH AND CENTRAL AMERICAN PVC PRODUCERS START-UP| COMPANY NAME YEAR 1 1953 | Monsanto Mexlca 1954 | Policvd 1955 | Geon Do Brazil 1956 | Elchlor/Solvav 1960 1 Electrochlor | Vldastlc 1961 | InduDa 1965 | PET Columbiana 1966 | Carburo De Col 1967 | Plastlcos Omeea | SOC Paramonea 1968 | Prlmex 1970 1 Pollcasa | Petro Dow 1971 | Pollmeros Mex 1975 | Rico Chemicals 1976 | Petroolas 1977 | Indust Reslstoc 1978 1 Huls Brasil 1 Polychem | Policvd 1979 _L PET Camacarl | LOCATION | 11 1 Lecherla (Mexico) 1 1 Mexico Cltv (Mexico) 1 Sao Paulo (Brazil) 1 1 Sao Caetano (Brazil) 1 |Capltan Bermudez(Argentina) 1 1 Mendoz (Areenttna) 1 1 Clnco Saltos (Argentina) 1 1 Cartaeena (Colombia) 1 1 Medellin (Colombia) J 1 Mexico 1 1 Paramonea (Peru) 1 1 Puebla (Mexico) 1 | Managua (Nicaragua) 1 1 ConceDtlon (Chile) 1 1 St Martin Puebla (Mexico) 1 1 Guvanilla (Puerto Rico) 1 1 EL Tablazo (Venezuela) 1 1 Tlazcala (Mexico) J | Cubato (Brazil) | El Salvador 1 Coatzacoalcos (Mexico) 1 1 1 1 Camacarl Bahia (Brazil) J ASL CASE 1 YEAR OF NUMBER _1_ 1st EXPOSURE ........... 1 l_ 1 1 1 __L_ 1 1 1 1 1 1 _J_ 1 1 1 1 --L CONFIDENTIAL - A 000079 UdLSiSW 61 (Review date February 1991) TABLE 14 AUSTRALASIAN PVC PRODUCERS START-UP DATES 1--------------------- -- -- -- -- |START-UP COMPANY NAME LOCATION ASL CASE YEAR OF | YEAR NUMBER 1st EXPOSURE |Mid 1950s ICI Australia Botany, Sydney 01 65 | 1960s B F Goodrich Melbourne |Late 1970s ICI Australia 1 1_____________ _______________________ Laverton Melbourne ' CONFIDENTIAL - A 0 0 0 0 8 0 szszstssy 62. (Review date February 1991) TABLE 15 MIDDLE EASTERN FVC PRODUCERS START-UP DATES 1---- 1 n---------------------------------- 1 -- -- |START-UP | COUNTRY NAME DATE 1| Company name LOCATION |Sept 1986 | Saudi Arabia National Plastic Arabian Petrochemical Company 1 Company Madlant 1 (Ibn Hayan) Al-Jubali l Al-Slnahyah 1 CONFIDENTIAL - A 000081 ezezsLssy 63. (Review Date February 1991) TABLE 16 NUMBER OF FACTORIES IN THE WORLD PRODUCING PVG So_far as known at 1 January 1991 (See Tables 8-15 of this ASL Register) Western Europe USA Canada Eastern Bloc Japan South and Central America Australasia Middle East TiS/'.SI-S'SU CLOSED 1 20 1 - 8 ^ 22 OPEN 53 30 4 23 26 22 3 1 172 64. CONFIDENTIAL - A 000082 CONFIOENTIA miD REGISTER OF CASES OF AMIOSAROMA OF THE LIVE* (A$l) due to VCM 1 2s COUNTRY AND NAME OR DATE OF REFERENCE INITIALS tIRTH NO A COMPANY s6 7 a9 TO 11 12 13 . U 15 FACTORY FIRST VC EXPOSURE YEARS OF DATE OF AGE AT EXPOSURE YEARS OF DIAGNOSIS DIAGNOSIS TO EXPOSURE DIAGNOSIS DATE OF DEATH HISTOLOGICAL ESTIMATED CONFIRMATION EXPOSURE OCCUPATION LEVEL OTHER CAREER highlights 16 OTHER COMMENTS ' CONFIDENTIAL - A 000083 g^ZSI-SW