Document ZBDOa5prm8KNzO056ZnLa2MkL
l d 50 o r a l t o x ic it y t e s t
DATE 7/*&..
MATERIAL
<&/UtWe,
PL O
PHYSICAL APPEARANCE
. .jQsmjiVaAJ
MR- JO BK.NO.___ PAGE jVSt H.NO. VbOO T.I. <Toyr Lo aJSOQ^C
DEPT.___________ DEPT.NO. ALP > \i,occ mg/ka D20_____________________ pH_
Material given by stomach tube to <?"Ch &.-& /?/) rs
si as a 6s- % ( ) solution of ( ) active ingredient in
suspension (*-) original sample
Ps a a /u t o /JL
Date S-/SL
No. Rats Dosed
JO
Av; Dose wtf me/ke
J 7.000
Av. 7. Dose Sol. (ml)
Vs JO. OS'
Av. Surv. Time (days)
aqfc;
Mort. Ratio
V*
&/r JO as? US, 060 <>sr 9.97
V/o
Remarks
TS Ato
* /a <4^c AJo
LD^q =) as.ooo mg/kg oA. Confidence Limits 2 =mg/kg
t&ATU
a3p.oo
1. gms/100 ml 2. "A Simplified Method of Evaluating Dose-Effect Experiments", by
J, T. Litchfield and F. Wilcoxon, J. Pharm. Exp. Therap., J96: 99 (1949)
DUP040002086
Clinical Signs:
~Z^eA^
'-fftt(Ms</'c^A- <U9-^-x^Z c4*^**&*->
_-t*S-4si^cAi -&o-^h -&C&JL. '/-A*
&**-' t~~tu ffbz*^. Ct^fc*-
.
<A**--*{ fousj-^bjf -u AS , 6l^\^xA^/'C^u' <Q^*y~e? '-jf-i***' s&*rt-a*f jZ-t-cc*A,
Pathology:
Summary: ijht* Z. ~^sn 'j-oA/ *&<*-/ <@si/<cit C P& 6,
eUKi*^j ^t^-4u
<3t- *-\*sCLf, to S*UX#s6l
- CZ?
~Jb*i*-^-' ty ooo '**'-$}<y / 0-Tpc-eU^Z^.
t*
tyi C^t^AA^lijUau' <L*-rtrt%strisU**-y -y(jt 66t^t-<^
^jU't-'Le-tP -M-'Lc 'Z/Le
a/-tH
a-i^t
M^A**^**~-J *^J a+^- -*- 3 ty ^
AxtfakS
<K^> <UjLU&^>-ea/ yV^
'*'' "' `i^ '^f"'
^ ><* y*,
^ V*"^ *- x*t **
<a*
13- cLo^tyO-'
'^O-^L^C',
Z7^O 6t 93-8 % P4**^4y c<s-c<^9vtr 'tdj, Z.J>^.0
' - f jf
'o V V ^
P&
~4-1*k ~4 o -^c^o Lz,
&*u*ts 33j 3oo
^
-- rM
DUP040002087