Document ZB36a15zOKaqJ8yJv4Xy2qEEY

t -V--* -1 y ' bio-medical* research DOCUMENT DESCRIPTION FORM Duplicate.in all cards: year as-1961-- File number (Right justify (Numeric only] Auth r (s), as Last Name FS (No Punctuation) and coden for journal as JAMA preceeded by one blank space 1 20 21____________ ________ 40 41 */ 77 78 C1 Sub-Index Code Title of Report; end with space-hyphen-hyphen-space. Follow with Index Terms. separated from each other with comma--space. Avoid other punctuations do not abbreviate. 12 ; ______________________ e. . 61 62 1 21 '/ y '-A ft 22 v"l-'/'a- r A'A'Ar s? jC-\ A 23 - . V< ,.'^7?/ r. *--- -- f-`A? j ?/'S' iT**//}^ 24 Source (Journal, Vol., Number, Pages, Date j 12 // m.'i . . ,c> <> . AA'/a AA'.czr/T .)//CcVAT^ * /',.CsAr V/ 7',V7A ,. /t * ,, . ,, r/s/yy-v -' .V / it j ^y-i /,r c 7> - -r- 1 1 62 31 ` ;. "c<VV.,A'>'.f 32 'y/Kj'n Brief Summary 1 2_____ 10 SUMMARY: 1 62 61 62 63 64 R&S 113272 ttaw Of Victoria from 1950 to 1978, using records from pathology laboratories, to determine any in crease in incidence and possible rural preponder ance. (2) A case control study of cases at Peter MscCallum since 1952, investigating residence (met ropolitan, town or rural), occupation, place of birth, religion and possible exposure to carcinogens. Cases have all been histologically classified to reveal relationships according to classification. Retrospec tive studies covering all the available case material; (1) To increase the numbers and (2) to detect any change in trends are being earned out, as well as a survey of pathologists' records. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 3.0536, BCELOPT EPIDEMIOUGY OF CANCER IN THE NATIVE INDIAN POPULATION OF ALBERTA LM. Laing, University of Alberta. Dept of Community Medicine. Edmonton, Atbarta, Canada T6G 2E1 (0IARC-79-69) Native Indian populations are In cultural-transition. The movement away tram aboriginal patterns of ad aptation is accompanied by changes in Sfestyle and exposure to factors which may increase the risk of cancer. Risk factors include changes in reproductive patterns, a diet based on processed foods, occupa tional exposure to toxic substances, and increasing use of alcohol, tobacco, and drugs. Published infor mation on cancer Incidence and morality among native populations Is relatively scent The pattern of incidence of cancers among native Indian and Eskimo popualtiona is different from that among other residents of North America. Malignant disease may ones have bean rare In native Indian and Eskimo populations. Cancan of tha gallbladder and nasopharynx ara significantly more frequent among native Indians. Cancers of the cervix and lung appear to have increased in relative prevalence. The Government of Canada maintains records of regis tered Indians through the Departments of Indian and Northern Affairs and Health and Welfare. There are approximately 32,000 registered Indians who are residents of Alberta. Lists of registered Indians will be matched with files of tha Alberta Cancer Registry and with death certificates. An historical prospective study of cancer incidence and mortality among native Indians will be undertaken. It is estimated that lor tha study period 1974-78 there will be about 100. cancer deaths. SUPPORTED BY (No Supporting Organization Re ported) funds ita. 3.0537, ^ > BOPT MONITORING THE -OCCUPATIONAL ENVIRON MENT FOR CARCINOGENS - A PILOT STUDY IN MONTREAL J. Smmmtycki, Armand Frappier Institut. Centre da Recherche en Epidemiologic et Mededne Preven tive, 31 Bhrd des Prairies, Case Postals 100, Laval das Rapidas, Quebec, Canada H7N 4Z3 (D-IARC-78- 78) Of the thousands of chemicals in tha occupational environment only a score have at present bean demonstrated to be human carcinogens. There is no human evidence one way or another for almost all Of the others. The vary large number of agents renders inadequate conventional 'one-factor-at-a-time' epide miologic study methods (case-control or cohort). Tha Objective is to establish an ongoing monitoring system capable of scanning the occupational envi ronment to detect hitherto unsuspected human car- nogens. A ease-control type methodology will be used. Cases will be adult male cancer patients hos pitalized in the Montreal region. Several sites will be included and each will be analyzed separately. In the pilot study, controls for each site will be selected from the cases with cancer of other sites. For each mar. a lifetime history of exposure to a large number of* agents will be ascertained. An innovative ap proach will be developed to ascertain occupational exposures which me worker might not be able to report or recall. This will be based on a self-admfnfstered questionnaire followed by en in-depth interview and e matrix relating specific chemical exposures to specific jobs. The matrix will be developed in consul tation wnn experts in the fields Of chemical end in dustrial engineering. A worker's exposure history will be inferred from his job history and the matrix. Tha analyses will aim to identify high risk chemicals and workplaces. A two-year feasibility study will evaluate diverse aspects such as case ascertainment, data collection methods, and the statistical sensitivity of /I. td U the system, before a long-term system is estab lished. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. 3.0542, I LPQT EPIDEMIOLOGY OF THYROID CANCER G. Maaaralli, Universita degli Studi di Sassari, Inst ot, Morbid Anatomy, Via Mahaotti 8. 07100 Sassai Italy (D-IARC-79-333) 3-0538, B LOTV CHILDHOOD CANCER AND PARENTS' OCCUPA TION KJ. Hemminki. Inst ot Occupational Health, Dept of Industrial Hygiene & Toxicology, Haartmaninkatu 1, SF00290 Helsinki 29, Finland (D-IARC-79-148) It is intended to check the incidence of thyroid cancer in Sardinia in order to Identify incidental clus tering and the relationship to environmental iodine Concentration. The survey will use the diagnoses from the three departments of pathology on the island. SUPPORTED BY (No Supporting Organization Re- ported) funds n.a. The study aims to find out whether any correlation exists between the occupational activities of parents 1 and cancer in their children. The material consists of cancer cases in children under 15 years notified by tha Finnish Cancer Registery in 1959-1968. The par ents' occupations ware traced tram the records of the antenatal clinics. Controls ware matched for aged end place of birth. The material Is being ana lysed to the occupation of tha parents. SUPPORTED BY (No Supporting Organization Re ported) funds na. 3.0543, BLOPQT MORTALITY EXPERIENCE AMONG POLYCHLO RINATED BIPHENYL WORKERS PJl BenasL Universita degli Studi di Milano. Inst, of Occupational Health, Dept, of Epidemiology, vie S Bamabe ft 20122 Milan. Italy (D-IARC-79-324) Animal experiment studies end some txanan data support a possible association between polychlori nated biphenyls (PCBs) exposure end cancer m men. The aim ot the study is to assess mortality in the period 1955-1975 among workers employed In a ca 3.0539, B OFO EVALUATION OF OCCUPATION AS RECORDED ON OEATH CERTIFICATES D.T, Wigh, Canadian Dept of National Health & Welfare, Lab. Centra for Disease Control, Tunneys Pasture, Ottawa, Ontario, Canada K1A 0L2 (D-IARC* pacitor and transformer industry operating since 1947. The personal records of the 2,317 workers employed since the beginning of manufacture have been obtained from the factory. For each subject date and piece of birth, date of entry and leaving the industry and type of work performed are available; date, place, and primary cause of death will be as i 79-87) Tha death certificates tor about 3.000 parsons dying of cancer and previously included in random samples of the Canadian Labour Force wB be examined to retrieve recorded information concerning major life time occupation. The occupations will be coded certained from death certificates. The sex. age and cause-specific mortality of people living in me same city where the factory is located will be used for Comparison. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. using standard occupational coding manuals pre pared for use in tha decennial census. The coded occupations wili then be compared with those previ 3.0544, BOPT ously recorded when tha individuals were interviewed during the Labour Force Survey. SUPPORTED BY (No Supporting Organization Re COHORT STUDY AMONG REFINERY WORKERS R. Puntoni, Universita degli Studi di Genova, Inst, da Oncologia. Dept of Epidemiology, Viate Benedetto -- ported) funds n.a. 1, c/o Ospedal Civile, 16132 Genoa, Italy (O-IARCf^ ' * 79-322) In the town of La Spezia there is a big refinery. The^^ 3.0540, B O PQT IS ANGIOSARCOMA OF THE UVER ASSOCIAT ED WITH VINLY CHLORIDE MONOMER EXPO SURE IN SOUTH AFRICA workers, approximately 500. at this refinery are ex posed to several petroleum denvates. Many of mesa chemicals are well known as carcinogens, such es polycyclic hydrocarbons. An investigation Into the causes Of deem in such workers is being carried /. Webstar, South African Medical Research Council. through and ail tha causes of death in the period National Research insL for Occupational Diseases, 1960 to 1977 complied. For comparison the expect Joubert SL Ext, Johannesburg 2001, Transvaal, ed number of deems will be estimated trom age- South Attica (D-IARC-79-488) Jn South Africa tha main producer of polyvinyl chlo apedfic male death rates for the La Spezia ipopuia- tion during the same period. -. - j ride plastic has two factories. It has been manufac- * -SUPPORTED BY (No Supporting Organization Re tureo at Umbogintwint sines 1950. but at tha Mid- ` ported) funds n.a lands factory for only eight years. The present labor " fores is being monitored by liver tests, Clinical and radiological examination. Ex-employees ara being 3.0545, BLOPT traced, especially those from Umbogintwml, where it is possible that the empolyees were exposed to viniy chlonde monomer and in whom tha possible latent period of 20-30 years has now bean reached. COHORT STUDY AMONG CHROMIUM-EXPOSED WORKERS R. Puntoni, Universita degli Studi di Genova, Inst, da Oncologia. Dept of Epidemiology, Viale Benedetto SUPPORTED BY (No Supporting Organization Re t. e/o Ospedal Civile, 16132 Genoa, Italy (D4ARC- potted) funds n,a. 79-321) In the Liguria region there is a factory that produces born hexavaient and bivalent chromium salts. Tha 3.0541, HLPOT ENVIRONMENTAL FACTORS AND THE DEVEL OPMENT OF SKIN CANCER workers in the factory are exposed to large doses of chromium. An investigation of the causes of deem among about 1,300 workers employed in the period t January 1958 to 1 January 1978 is being undertak DM Cerimeie, Universita degS Studi di Sassari, Dept of Dermatology. VMe Manor* 5, 07100 Sas sari, Italy (D-IARC-79-331) There is ample evidence that environmental factors and particularly prolonged exposure 10 the rays of en. The expected deaths will be calculated on me basis ot the deem rates for the people tivfng in the two villages surrounding the factory. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. the sun play a significant role m the development ol skin cancer. This study intends to determine the actual incidence of skin cancers in Sardinia, and the 3.0546, EP QT degree to which environmental and constitutional factors are involved. A questionnaire, oeveloped for CANCER OF THE OROPHARYNX - A CASECONTROL STUDY the present study, collects information from skin cancer patients on place of birth, place of of resi dence during last ten years, place of present resi dence. color of the skin, eyes and hair, capacity to tan and time of exposure to the sun. Patients treated are followed up in oreer to establish if people who develop skin cancer are prone to develop new can cers Of the skin or inner organs in the future. SUPPORTED BY (No Supporting Organization Re ported) funds n.a. S. Sivayoham, National Cancer Registry. DepL ot Healtn Services, 385 Deans Rd.. Colombo 10, Sri Lanka (D-IARC-79-4S7) The data available from the Sri Lanka Natio Cancer Registry show mat oropharyngeal neoplas form 39*/* of all cancers in Sri Lanka. The ageadjusted rates when compared with other cancer registries are very high, if not me highest For exam ple. the age-adjusied rate for mourn cancers is 56.7 for males and 20.5 for females, many times higher R&S 113273 t i Ii i i r \ t t 1-61 TOXICOLOGY RESEARCH PROJECTS DIRECTORY Volume 5, Number 3 March 1980 3J </> co An Indexed Directory of Current Research Project' Abstracts In Toxicology and Related Fields Published Monthly By The Toxicology information Subcommittee of the DHEW Committee to Coordinate Toxicology and Related Programs DHEW PUBL. NO.(OS)76-50030